Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The illumination is controlled to target a particular volume of the medium and/or such that the spectral energy changes become directionally monotonic with respect to analyte concentration.

Abstract: The present invention relates to a method for determining the amount of total phosphate in a body of water from reflected light, and also includes systems for the measurement, calculation and transmission of data relating to or carrying out that method. In addition, the invention relates to methods and systems for determining other parameters of water quality from reflected light, for example, turbidity, dissolved oxygen and/or nitrogen.

Abstract: A method of deriving correction for instrument-to-instrument variations in the illumination band centroid wavelengths and wavelength band shapes of the optical systems of clinical chemistry instruments includes the steps of determining the centroid wavelength and wavelength band shape of a light source used in the optical system of a clinical chemistry instrument to provide a determined wavelength band shape and centroid wavelength, comparing the determined wavelength band shape and centroid wavelength with a known reflection density or absorbance wavelength spectrum of a specific type of chemical reagent test to provide a correction value, and calculating the correction value, which is to be used to modify a reflection density or absorbance measurement taken by the instrument of a reagent test of the a specific type of chemical reagent test.

Abstract: The present invention provides for metallic nanostructures or nanoburgers comprising a dielectric layer positioned between metallic layers and their use in metal enhanced emissions systems to enhance emissions from fluorophores, including intrinsic and extrinsic; luminophores; bioluminescent species and/or chemiluminescent species. The multilayer nanoburgers exhibit several distinctive properties including significantly enhanced intensity of emissions, decreased lifetime and increased photostability by simply varying the thickness of the dielectric layer while maintaining a constant thickness of the two metallic layers on opposite sides of the dielectric layer.

Abstract: The invention provides a method and apparatus for determining the amount of various materials in a liquid sample. Because the apparatus is particularly resilient it can be used repeatedly with very harsh liquid samples such as boot water from an oil refinery. The apparatus uses at least one volume and/or concentration independent optical analysis method to determine at least one of: the pH, amount of chloride, and/or amount of iron in the sample. The optical property can be colorimetric, fluorescent or both and result from adding dyes, complexing agents, turbidity inducing compounds, and other optically effecting reagents to the sample. Because the measurements are concentration and volume independent they can be done continuously, quickly, and avoid the inconvenient start and stop procedures in prior art measurement regimens.

Abstract: An optical fluorescence-based sensor comprising at least one sensing element is disclosed. In one aspect, the at least one sensing element comprises a waveguide comprising a waveguide core, a light source optically coupled to an input part of the waveguide core, and a photodetector optically coupled to an output part of the waveguide core, the waveguide core being made of a material comprising a mixture of an optical material and a fluorescent dye.

Abstract: An apparatus for detecting a defect of an object may include a light emitter configured to emit straight polarized lights having different polarized directions, a spatial filter having openings through which the straight polarized lights selectively pass, an optical member configured to condense the straight polarized lights, which pass through the openings, on the object, and a light detector configured to detect lights reflected from the object. Thus, the defect may be accurately detected in a short time.

Abstract: Photoelectron emission mapping systems for use with EUV (extreme ultraviolet) mask inspection and lithography systems are described. The mapping systems may be used to provide photoelectron emission maps for EUV photolithography masks and/or EUV mirrors. The systems use EUV photoelectron sources used for mask inspection or photolithography to impinge EUV light on the masks and/or mirrors. The EUV light generates photoelectron on the surfaces of the mask and/or mirrors and the photoelectrons are collected and analyzed by detectors placed away from optical spaces of the EUV chamber.

Abstract: Methods of evaluating a superabrasive volume or a superabrasive compact are disclosed. One method may comprise exposing a superabrasive volume to beta particles and detecting a quantity of scattered beta particles. Further, a boundary may be perceived between a first region and a second region of the superabrasive volume in response to detecting the quantity of scattered beta particles. In another embodiment, a boundary between a catalyst-containing region and a catalyst-diminished region of a polycrystalline diamond volume may be perceived. In a further embodiment, a boundary may be perceived between a catalyst-containing region and a catalyst-diminished region of a polycrystalline diamond compact. Additionally, a depth to which a catalyst-diminished region extends within a polycrystalline diamond volume of a polycrystalline diamond compact may be measured in response to detecting a quantity of scattered beta particles. A system configured to evaluate a superabrasive volume is disclosed.

Abstract: An X-ray radiography system for differential phase contrast imaging of an object under investigation by phase-stepping is provided. The X-ray radiography has an X-ray emitter for generating a beam path of quasi-coherent X-ray radiation, an X-ray image detector with pixels arranged in a matrix, and a diffraction or phase grating, in which the X-ray emitter has an X-ray tube with a cathode and an anode. The X-ray tube is constructed in such a way that an electron ray beam originating from the cathode is associated with focusing electronics which produce, from electrons which are incident on an anode, at least one linear-shaped electron fan beam.

Abstract: The present disclosure provides a method and an apparatus for generating a representation of an internal structure of an object. The method comprises the steps of providing radiation that is arranged to traverse through at least a portion of the object and directing the radiation from different angular directions through at least a portion of the object and towards an optical element, such as a lens or pin-hole. The method also comprises the step of forming a radiation exposure pattern using the optical element, the radiation exposure pattern comprising information indicative of the propagation directions and intensities of component radiation that form the radiation exposure pattern. In addition, the method comprises calculating the representation of the internal structure from the radiation exposure pattern. The method is conducted such that the radiation exposure pattern corresponds to a respective point of view of the object.

Abstract: The instant application relates to an X-ray sensitive battery separator for a secondary lithium battery and a method for detecting the position of a separator in a secondary lithium battery. The X-ray sensitive battery separator includes a microporous membrane having an X-ray detectable element therein, thereon, or added thereto. The X-ray detectable element constitutes less than 20% by weight of the microporous membrane or separator. The method for detecting the position of a separator in a battery, cell, stack, jellyroll, can, or the like includes the following steps: (1) providing a battery, cell, stack, jellyroll, or the like including an X-ray sensitive battery separator; (2) subjecting the battery, cell, stack, jellyroll, or the like to X-ray radiation; and (3) thereby detecting the position of said separator in said battery, cell, stack, jellyroll, or the like.

Abstract: A system, comprising at least one source for irradiating electromagnetic radiation into a sample fluid and a reference fluid resulting in a change in a temperature of the sample fluid and a change in a temperature of the reference fluid, and a processing subsystem that monitors and determines a concentration of a gas of interest dissolved in the sample fluid based upon a difference between the change in the temperature of the sample fluid and the change in the temperature of the reference fluid, wherein the reference fluid does not contain the gas of interest, and the electromagnetic radiation has a wavelength range corresponding to a spectral absorption range of the gas of interest.

Abstract: In one example, a thermal conductivity gas sensor is disclosed. The sensor includes a sensing element and an amplification material coupled to the sensing element. The amplification material has a target gas dependent thermal diffusivity. The sensing element measures the thermal diffusivity of the amplification material to determine a target gas concentration.

Abstract: A multi-functional precious stone testing apparatus includes a portable housing, a testing unit, and an indication unit. The portable housing includes a hand-held casing and a probe casing extended from a front end of the hand-held casing. The testing unit includes a conductive probe having a testing end portion extended out of a tip end of the probe casing for contacting a testing object to determine a conductivity of the testing object. The indication unit includes a LED light unit received in the hand-held casing for illuminating the testing end portion of the conductive probe during testing, wherein the LED light unit is positioned away from the tip end of the probe casing for preventing heat generated from the LED light unit being transmitted toward the conductive probe to affect an accurate measurement for the conductivity of the testing object.

Abstract: Disclosed herein is an apparatus comprising a metal shunt and a semiconductor material in electrical contact with the metal shunt, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to planes in which the semiconductor material and the metal shunt lie, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.

Abstract: The invention discloses methods and devices for rapidly detecting a biological or other residue in a liquid sample. In some embodiments of the instant invention, a single electrode is employed to contact a flowing aqueous solution, with electrical outputs being recorded by an electrical metering device. Injection or flow of sample leads to changes in solution electrostatic behavior; those changes are recorded in the metering device, with absence of predetermined residues or targets yielding the highest signals. General and specific target detection may be performed with various embodiments of the instant invention.

Abstract: The invention provides a Bottom Contacted 2D-layer Device (BCD) for the determination of graphene doping and chemical sensing. The device can be made by transfer of high quality CVD grown graphene films onto n- or p-doped silicon substrates yielding Schottky barrier diodes. Exposure to liquids and gases change the charge carrier density in the graphene and as a result the electrical transport of the device is modulated. The changes can be easily detected and interpreted in the doping power of the adsorbent. This principle allows one to create a new type of chemical sensor platform exploiting the monolayer nature of graphene or other carbon material. The device benefits from facile fabrication and the result is a robust device which can investigate surface chemistry on monolayer materials.

Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber.

Abstract: An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer, a light guide area, and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. The light guide area transmits light towards the capillary space.

Abstract: A device includes an upper metallic layer, a lower layer, and a nano sensor array positioned between the upper and lower layers to detect a presence of a gas, a chemical, or a biological object, wherein each sensor's electrical characteristic changes when encountering the gas, chemical or biological object.

Abstract: In a gas sensor element of a gas sensor, reference oxygen chamber (113) assumes the shape of a rectangular parallelepiped. A reference electrode (111) is disposed on a surface of a third solid electrolyte body (73) which is exposed to the reference oxygen chamber (113). A second outer electrode (117) is disposed opposite the reference electrode, on a surface of a second solid electrolyte body (77) which is exposed to the reference oxygen chamber. Further, a porous, insulative protection layer (165) is formed so as to cover the entire surface of the second outer electrode. A gap (167) is present between the reference electrode and the insulative protection layer. The thickness of the gap is greater than that of the insulative protection layer.

Abstract: A differential transformer type magnetic sensor includes a board, a drive coil, a first differential coil, and a second differential coil. The drive coil includes a planar coil in which a dimension of a first direction is smaller than that of a second direction, and is disposed on the board. The first differential coil includes a planar coil having the same shape as the drive coil, and is disposed on the board. The second differential coil includes a planar coil having the same shape as the drive coil, and is disposed on the board. The first differential coil and the second differential coil are electrically connected so that a direction of induced current flowing along the first differential coil and a direction of induced current flowing along the second differential coil are opposite to each other.

Abstract: In conventional non-destructive inspection devices using magnetism, the subject of inspection was limited to the surface layer of the test object as a result of the skin effect, and it was not possible to perform flaw detection inspection at the interior or reverse surface of thick-structured test objects. The effect of the surface effect was eliminated by imparting an external signal canceling the detection output of the test object surface layer from the detection output of a magnetic field resulting from eddy currents induced in the test object. As a result, it has become possible to extract the detection output of the test object interior that had been masked by the detection output of the test object surface layer, and it has become possible to perform thickness inspection and flaw detection of the reverse surface and interior or a test object.

Abstract: The eddy current flaw detection probe (100) includes a first yoke (1), a second yoke (2), a first permanent magnet (3), a second permanent magnet (4), a sensing coil (6). The second yoke (2) is inserted in a freely insertable and extractable manner along an inner peripheral surface of the first yoke (1).

Abstract: An ultrasonic flaw detector including an ultrasonic probe for emitting an ultrasonic wave on an object to be inspected and receiving a reflected ultrasonic wave from the object, a drive element control unit for controlling a plurality of ultrasonic elements to emit an ultrasonic wave from the ultrasonic probe and to control a reflected ultrasonic wave from the object, and a calculation unit for obtaining, by using a refraction angle of the ultrasonic wave at a time of the ultrasonic wave entering the object, an incident position of the ultrasonic wave on a surface of the object, and a surface shape of a surface of the object at the incident position, the incident angle of the ultrasonic wave entering the incident position, and obtaining a plurality of ultrasonic elements to be driven, based on the incident position and the incident angle.

Abstract: A crack and thickness detecting apparatus for detecting a crack in a wafer and also detecting the thickness of the wafer. The apparatus includes an ultrasonic oscillating unit oscillating a first ultrasonic wave toward the upper surface of the wafer at a predetermined incident angle, an ultrasonic oscillating and receiving unit oscillating a second ultrasonic wave toward the upper surface of the wafer in a direction perpendicular thereto and also receiving reflected waves obtained by the reflection of the first and second ultrasonic waves from the wafer, a crack determining unit determining whether or not the crack is present in the wafer according to the first reflected wave, and a thickness calculating unit calculating the thickness of the wafer according to the second reflected wave. The ultrasonic oscillating and receiving unit alternately receives the first reflected wave and the second reflected wave.

Abstract: This application relates to methods and apparatus for monitoring of conduits, especially oil or gas pipelines, as an object such as pipeline pig moves within the conduit. The method comprises monitoring at least part of a conduit (206) using a fibre optic (202) distributed acoustic sensor (204) as the object (208) passes along the conduit. The acoustic signals detected from at least one sensing location (203) as the object moves along the conduit are analysed so as to discriminate acoustic signals received at said sensing location from different locations. The method allows the contributions to the acoustic signal at a given sensing portion from different locations to be separately identified, and can allow the detection of the location of acoustic sources along the conduit even if the source is outside the section of conduit which is monitored. The method provides a method of leak detection that can extend the monitoring of the pipeline beyond the location of the optical fibre.

Abstract: The invention may be embodied as a fingerprint scanner having an ultrasonic wave detector, a platen, an ultrasonic wave generator located between the detector and the platen. The invention may be embodied as a method of scanning a finger. One such method includes providing a platen, a detector and a generator, the generator being placed between the platen and the detector. A finger may be provided on the platen, and an ultrasound wave pulse may be sent from the generator toward the finger. The wave pulse may be reflected from the finger, and received at the detector. The received wave pulse may be used to produce an image of the finger.

Abstract: A pulse generation circuit and method includes using digital signals to trigger a first and second varying analog signals and detecting when they reach one or more reference levels. In response to the first and second varying analog signals reaching one or more reference levels, a first and a second digital control signals are produced and provided as input to a pulser producing a voltage excitation pulse having a width and timing defined by the first and second digital control signals.

Abstract: To heat a flowing liquid, an apparatus includes a heater block assembly having a heater block made of thermally conductive material. The heater block assembly has a tube inlet, a tube outlet, and a tube path between the tube inlet and tube outlet. Tubing extends through the tube path from the tube inlet to the tube outlet. The tubing is in thermal communication with the heater block. A heater cartridge, in thermal communication with the heater block, is configured to provide heat to the heater block for transfer to liquid flowing through the tubing between the tube inlet and the tube outlet of the heater block assembly. Circuitry is in electrical communication with the heater cartridge to control a temperature of the heater block by controlling operation of the heater cartridge.

Abstract: An apparatus and a method for chromatogram peak purity determination are provided, where the chromatogram's dimensions consist of retention time, wavelength and absorbance. The apparatus or method accumulates, at each retention time, absorbance in the wavelength direction for all or a part of a wavelength range in a predetermined retention time range; extracts a plurality of groups where, for each group, the absorbance accumulation value is the same for one point on a rising slope and one point on a falling slope regarding a peak that exists on a chromatogram that is prepared based on a 2-dimensional data whose dimensions are absorbance accumulation value and retention time; calculates similarities between absorption spectrum pattern at one point on the rising slope and at one point on the falling slope for each group; and determines from the plurality of groups, whether the peak consists of a single component based on similarity.

Abstract: A system includes a computing device including a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations including initiating transmission of incident light from one or more light sources to a sealed bottle containing liquid. The operations also include receiving scattered light from the liquid contained in the sealed bottle. The operations also include processing one or more signals representative of the scattered light to detect interactions of the incident light with a particular molecule.

Abstract: A system for surveillance of a pool containing a liquid such as water-comprises at least one first element comprising at least one submersible robot provided with standalone propulsion capabilities for propelling the robot in the pool, onboard of which robot is installed at least one sensor capable of producing at least one measurement of a quantity representative of at least one disturbance of the pool relative to a reference state, the first element being furthermore provided with communication capabilities for communicating, in the submerged position, with at least one second element, the system being configured to process, in processing means, the output of the at least one sensor and to trigger at least one action.

Abstract: Method and system is described for hydrocarbon exploration and development. The method and system include one or more remote devices, such as buoys, which are utilized to identify and collect samples of target materials. The buoys include measurement components, sampling components and storage components to manage the obtained samples.

Abstract: A test device including a closeable cavity and a water flow groove with a water transmission channel existing between the water flow groove and the internal part of the cavity. The water flow groove includes a water inlet and a water outlet with the depth of the water inlet being greater than the depth of the water outlet. Simultaneously, side lead-in pipe of drain pipe and elbow pipe on side wall of water inlet pipe are consistent with height of top surface of the ceramic plate, making hydraulic pressure of tested soil sample being zero during dehydrating and soaking process capable of ensuring accuracy of test result. A necking design is applied to reduce water evaporation in the drainage pipe and lower the test errors. Side lead-in pipe is connected with drainage pipe for smoothly draining water and also can prevent air reversely flowing and entering into the base.

Abstract: The present invention generally relates to a novel method for the characterization and quantification of involatile macromolecules in hydrocarbon samples of crude oil. More particularly, the method utilizes pyrolysis/gas chromatography/mass spectrometry (PY/GC/MS, PY/GC/MS/MS or PY/GC/triple quad MS) to detect and quantify polymeric asphaltene inhibitors in crude oil.

Abstract: A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.

Abstract: The present invention pertains to a biological sample measurement device, which is intended to be easier to use. To achieve this object, the present invention comprises a main body case (1) having a sensor insertion opening into which a sensor for measuring biological samples is inserted, a connection terminal (20) provided within the main body case (1) behind the sensor insertion opening, (5) and a shutter 7 that is provided within the main body case (1) between the sensor insertion opening (5) and the connection terminal (20) and that opens and closes the sensor insertion opening (5). This configuration makes the device easy to use.

Abstract: Apparatus and methods are provided for detecting and monitoring proteolysis of protein matrices such as fibrin clots, extracellular matrix and collagen matrix. The apparatus and methods involve in general the measurement of diffusion-limited electrochemical currents generated by an electroactive species or elactomer in a synthetic protein matrix. The apparatus and methods are applied in various embodiments to detect and monitor the proteolytic activities of a sample, and more specifically fibrinolytic activities and collagenase activities of a sample. The apparatus and methods are utilized generally in the monitoring and diagnostics of cardiovascular, cerebralvascular, and oncology conditions.

Abstract: An electrode element and fuel cell and a new method of manufacturing a fuel cell, particularly for use in a breath alcohol detector. This new element includes a reservoir for extra electrolyte that can allow near perfect capillary action to keep the electrode substrate full of electrolyte for long periods of time, increasing its useful life, especially under harsh conditions. Further, the capillary action need not work through a layer of electrode and can be integrally formed with the electrode element to eliminate or reduce loss due to connective surfaces. Wire connections and arrangements are generally of no concern in this design as the reservoirs for electrolyte connect directly to the substrate and electrolyte does not need to pass through an electrode.

Abstract: The present invention relates to a method for screening a modulator of a TMEM16 family member, which comprises the following steps: (1) treating cells expressing the TMEM16 family member with a candidate of the modulator, and (2) determining whether the candidate alters distribution of a lipid selected from phosphatidylserine, phosphatidylcholine, and galactosylceramide in plasma membrane of the cells, wherein a candidate which increases distribution of phosphatidylserine in the outer leaflet of plasma membrane compared to control is selected as a modulator enhancing a function of the TMEM16 family member, and a candidate which decreases distribution of phosphatidylserine in the outer leaflet of plasma membrane compared to control is selected as a modulator suppressing a function of the TMEM16 family member, and a candidate which increases distribution of phosphatidylcholine or galactosylceramide in the inner leaflet of plasma membrane compared to control is selected as a modulator enhancing a function of

Abstract: This disclosure is directed, in part, to a method of determining whether a subject having cancer is at risk for developing metastasis of the cancer. In one embodiment, the method comprises (a) obtaining a biological sample from the subject having cancer; (b) determining CCR5 expression level and/or expression level of at least one of CCR5 ligands in the biological sample; and (c) if the expression level of CCR5 and/or of at least one of CCR5 ligands determined in step (b) is increased compared to CCR5 expression level and/or expression level of at least one of CCR5 ligands in a control sample, then the subject is identified as likely at risk for developing metastasis of the cancer.

Abstract: Novel grafted dinuclear metal complexes having formula (I) or of formula (II) wherein M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterising cellular microparticles.

Abstract: The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ITO) covered transparent glass slides. This provides, inter alia, glycan arrays on a micrometer scale which allow multimodal readout by MALDI-Tof-MS, fluorescence and optical microscopy. Glycans functionalized with a C5-aminolinker were attached in situ on a picomolar scale to a hydrophobic tag bound to this surface, thus avoiding the wasteful off-chip ligand tagging of other approaches. Glycan arrays prepared using this methodology were analysed both with a fluorescence scanner and by on-chip MALDI-mass spectrometry in a series of glycomics experiments specifically requiring a multimodal readout.

Abstract: A microfluidic device, a microfluidic system and a method for controlling a microfluidic test device are provided.

Abstract: The present invention provides a method for selecting dopaminergic neuron progenitor cells, which comprises detecting any one or more of markers selected from the group consisting of CD15 (SSEA-1), CD24, CD46, CD47, CD49b, CD57, CD58, CD59, CD81, CD90, CD98, CD147, CD184, Disalogangliosid GD2, SSEA-4, CD49f, SERINC4, CCR9, PHEX, TMPRSS11E, HTR1E, SLC25A2, Ctxn3, Ccl7, Chrnb4, Chrna3, Kcnv2, Grm2, Syt2, Lim2, Mboat1, St3gal6, Slc39a12, Tacr1, Lrtm1, Dscam and CD201.

Abstract: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.

Abstract: The present invention deals with reagents and compositions capable of effectively inhibiting peroxidase activity. According to the invention, peroxidase enzymatic activity is blocked with an acidic aqueous solution of a protein denaturing agent. Preferred protein denaturing agents are detergents and chaotropic substances.

Abstract: Novel compounds, having an azlactone function, of formula (I), to be used as multifunctional coupling agents, and a method for coupling a biomolecule and a target molecule using such a compound are described. A diagnosis reagent, a kit for implementing the coupling method, a method for separating, detecting and/or characterizing at least one molecule of interest, and a composition including a novel compound are also described.