Abstract: The invention is directed to an ion plasma deposition (IPD) method adapted to coat polymer surfaces with highly adherent antimicrobial films. A controlled ion plasma deposition (IPD) process is used to coat a metal or polymer with a selected metal/metal oxide. Exposing the coated surface to ultraviolet light significantly improves the antimicrobial properties of the deposited coatings.

Abstract: This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.

Abstract: A vacuum pressure regulator system is provided for use in association with a vacuum system in which a vacuum is employed for healthcare purposes, for assisting in monitoring and regulating the vacuum pressure, and having a manual pressure control valve to adjust the treatment vacuum pressure supplied to the patient, a vacuum pressure sensor to sense the treatment vacuum pressure for the patient in the system, and producing a treatment vacuum pressure signal, a sampling circuit which intermittently samples the pressure signal generated by the pressure sensor and generate sampling signals, an electrically powered pressure display circuit, and digital pressure display, for receiving the sampling signals and providing a visible display, and a non-mains power supply.

Abstract: In one example embodiment, an apparatus for providing negative-pressure therapy may comprise a negative-pressure source, a pressure sensor, and a control valve. The negative-pressure source may be configured to be fluidly coupled to a distribution component. The control valve may be fluidly coupled to the pressure sensor and configured to be selectively coupled to the negative-pressure source, the distribution component, or both. A controller may also be configured to operate the control valve to selectively couple the pressure sensor to at least one of the negative-pressure source and the distribution component through the control valve, and the pressure sensor may provide a feedback signal to the controller indicative of pressure in a feedback path associated with the position of the control valve. The controller may also be configured to operate the negative-pressure source based on the feedback signal.

Abstract: A bursitis treatment device (100; 200) for treatment of inflammation of a bursa (150; 502) in a patient's joint includes: a rinsing aid; a reservoir (101; 201) for holding the rinsing aid in fluid, freezing fluid or gaseous state; a supply line (103; 204, 208) for transporting the rinsing aid; a heat exchanger (104; 203) for controlling the temperature of the rinsing aid—such that the temperature of the rinsing aid enables to destroy cells causing the inflammation; an access device (209) for injecting the rinsing aid into the bursa (150; 205); and a drain (105; 210) for removing the rinsing aid from the bursa (150; 205) for elimination.

Abstract: The present invention relates to a negative pressure wound closure system and methods for using such a system. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Preferred embodiments can utilize tissue securing portions that aid in securing the invention within a wound.

Abstract: A breast milk storage system which comprises a mandrel for selective engagement with a bottle connector of a breast pump. The storage system also includes at least one clamp in pivotal engagement with the mandrel, and a lock ring. The lock ring is positioned for rotation about the mandrel and the at least one clamp. Rotation of the lock ring effectuates pivoting of the at least one clamp between an open position and a closed position. In the closed position, the at least one clamp is pivoted with respect to the mandrel and presses against the mandrel so as to retain a storage bag in place by pinching said storage bag between the at least one clamp and the mandrel.

Abstract: Methods and systems for an improved feedback milk extraction system are described. According to aspects, the system may communicate with various electronic devices and/or server components to exchange data and perform certain functionalities. The functionalities may include providing visual and audio feedback to a user, supporting unique kit identification as well as associated user profiles and preferred configuration settings, detecting and responding to leaks having various sizes during operation of the breastpump, controlling operation of the breastpump in response to detected leaks and the detected type and/or magnitude of the leak, preemptively contacting customers if a fault condition is detected or imminent, enabling effective labeling of collection containers, and determining volume and flow of expressed breastmilk.

Abstract: A wearable machine system includes a garment and a passive actuator mounted to the garment. The passive actuator is actuatable in response to involuntary movements of a wearer of the garment. A machine is coupled with the passive actuator such that actuation of the passive actuator responsive to the involuntary movements mechanically drives the machine.

Abstract: Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: An implantable connector assembly (14) for communicating an element to an implantable device (12) within a patient (20) comprises a plug (16), a receptacle (18), and a pair of communication structures (72, 108). The plug (16) includes a plunger body (64). The receptacle (18) includes a sleeve (98) and a stopper (114). The sleeve (98) defines an opening (104), and the stopper (114) is resiliency mounted within the sleeve (98) to cover and fluidly seal the opening (104). The pair of communication structures (72, 108) is positioned respectively on the plunger body (64) and the sleeve (98). One of the communication structures (72, 108) connects to a source and the other communication structure (108, 72) connects to the implantable device (12). The plunger body (64) inserts into the sleeve (98) to displace the stopper (114) and couple the pair of communication structures (72, 108) for communication of the element therebetween.

Abstract: A hemodynamic flow assist device includes a miniature pump, a basket-like cage enclosing and supporting the pump, and a motor to drive the pump. The device is implanted and retrieved in a minimally invasive manner via percutaneous access to a patient's artery. The device has a first, collapsed configuration to assist in implantation and a second, expanded configuration once deployed and active. The device is deployed within a patient's aorta and is secured in place via a self-expanding cage which engages the inner wall of the aorta. The device includes a helical screw pump with self-expanding blades. Also included is a retrieval device to remove the hemodynamic flow assist device once it is no longer needed by the patient. Also included is an arterial closure device to close the artery access point after implantation and removal of the hemodynamic flow assist device.

Abstract: Methods and apparatuses for detection of gas bubbles in a microchannel configured for a conductive fluid to flow therethrough. The methods and apparatuses utilize a plate and at least two aligned electrodes embedded within the plate. The plate is configured to be located over the microchannel such that the at least two aligned electrodes are located along a length of the microchannel in the flow direction. Impedance is measured between the electrodes, and the percentage of gas within the fluid flowing through the microchannel is measured based on the measured impedance between the electrodes.

Abstract: An automated peritoneal dialysis therapy device includes pump tubing for delivering dialysate to a patient and for removing waste from the patient; a retractable peristaltic pump assembly; and a processor for controlling operations of the automated peritoneal dialysis therapy device. The retractable peristaltic pump assembly includes a retractable peristaltic pump having a pump rotor and a pump base, a heating source, located in the pump base, to heat the dialysate, a first temperature sensor to measure a temperature of the heating source, a second temperature sensor to measure a temperature of the dialysate, a flow sensor to measure an amount of dialysate being pumped, a pressure sensor to measure a pressure of the dialysate being pumped, and a motor to rotate the pump rotor. The processor controls rotational speed, displacement, and a direction of the pump rotor.

Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.

Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.

Abstract: A device and method for producing a portion of platelet rich plasma from a fluid sample obtained from a patient. The device comprises three intercommunicated portions, each portion having an internal chamber defined therein. The fluid sample is first brought into the base portion where it is separated into red blood cells and plasma. The plasma portion of the sample is then withdrawn into the second portion where it is further separated into platelet poor plasma disposed over platelet rich plasma. The portion of platelet poor plasma is then withdrawn from the second chamber, leaving only platelet rich plasma within the second chamber. The base portion also includes a membrane located on its distal end which helps maintain a vacuum within the device when the fluid sample is being initially inserted into base chamber.

Abstract: Devices for washing a composition including cells are provided. The devices include a separation channel, a first wave component and a second wave component. The separation channel is positioned between the first and second wave components. Collectively, the wave components generate a standing bulk acoustic wave that isolates cells from the composition.

Abstract: A fluid management system includes a disposable cassette carrying inflow and outflow tubing sections that are configured for releasably mating with a console including a control unit and a pair of roller pump heads. The console may automatically identify the disposable cassette and weigh the fluid in an inflow source. During operation, the system can monitor pressure in the working space, and provide for inflow and outflow control to maintain any desired operating parameters.

Abstract: A medical pump provides programming to assist a patient in complying with treatment schedules involving varying dosages of medicament(s).

Abstract: A compact intravenous pump and medication container holder. The present invention has a substantially flat base having a peripheral edge with one or more sidewalls placed along the edge. The sidewalls are positioned substantially perpendicular to the base, forming an interior adapted to removably secure an intravenous pump. An arm is placed substantially perpendicular to the base on one side thereon and extends upward therefrom. The arm has a first end secured to the base, and a second end having a fastener adapted to support a medication container. A strap is affixed to one side of the base and is adapted to secure an intravenous pump to the base.

Abstract: A portable medical device includes an interface for accepting a power supply and enabling data transfer while still connected to a human body. The interface may include a universal serial bus interface and may be coupled to a data isolation chip and a power isolation chip. A power controlling processor may determine how the supplied power, e.g., voltage, is supplied to other components within the infusion device. Additional circuitry within the system may provide a secure power transfer within the device to ensure user safety and ensure that a high frequency noise is properly attenuated.

Abstract: An implantable drug delivery device, comprising a check valve, a locking device, a drug delivery device body capable of being connected to a well-matched catheter through a locking device, wherein the drug delivery device body further comprising a pump frame, a well-matched punctured diaphragm disposed on the top of the pump frame, a pump cover well-matched with pump frame and punctured diaphragm disposed on the top of the punctured diaphragm, the pump cover, punctured diaphragm and pump frame sealingly connected to each other; and a check valve connected to the pump frame, wherein a pump cavity is formed by the pump cover, punctured diaphragm, pump frame and the check valve forming a pump cavity.

Abstract: An infusion pump system includes at least one reservoir having a reservoir volume, and an infusion pump including a pumping mechanism operably coupled to the at least one reservoir, a processor including a memory and configured to control operation of the pumping mechanism, and a calculation module configured to determine at least one characteristic about the at least one reservoir.

Abstract: An intravenous delivery system may operate by gravity feed, and may have a liquid source containing a liquid, a drip unit that receives the liquid from the liquid source, and tubing that receives the liquid from the drip unit for delivery to a patient. A flow rate sensor may be used to measure a flow rate of liquid through the intravenous delivery system, and may generate a flow rate signal indicative of the flow rate. A controller may receive the signal, and may compare the flow rate with a desired flow rate. If the flow rate is more or less than the desired flow rate, the controller may transmit a control signal to a flow rate regulator. The flow rate regulator may receive the control signal and, in response, modify the flow rate to bring the flow rate closer to the desired flow rate.

Abstract: A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect the treatment of a person, such as by initiating, pausing, halting or adjusting the dosage of drugs administered to the person.

Abstract: Described is an actuation mechanism for a medicament delivery device having a needle with a distal tip. The actuation mechanism comprises an outer sleeve telescopically relative to the delivery device and an inner sleeve telescopically arranged relative to the outer sleeve. The outer sleeve is axially translatable relative to the delivery device, and the inner sleeve is axially translatable relative to the outer sleeve. In a first state, the inner sleeve protrudes distally from the outer sleeve and the outer sleeve protrudes distally from the delivery device. In a second state, the inner sleeve is contained within the outer sleeve. Movement of the outer sleeve proximally relative to the delivery device in the second state initiates delivery of a medicament in the delivery device.

Abstract: An auto-injector pen has an outer housing (12, 14) which has a proximal end (18) and a distal end (16), an inner housing (84) having a cartridge (74) therein, the cartridge (74) containing a medicament and having one end thereof sealed by pierceable member (80), a needle hub (64) having first and second piercing tips (68, 70) which are in fluid communication, an actuating assembly (28) which moves an actuator from a first position to an activated position wherein the first piercing tip (68) extends outwardly of the outer housing (12,14) at the proximal end (18) and the second piercing tip (70) pierces the pierceable member (80), a first trigger (22) located at the distal end (16) and a second trigger (98) located at proximal end 18, the arrangement being such that the second trigger 98 must be activated to permit activation of the first trigger (22).

Abstract: A sub-assembly of a medicament delivery device, the sub-assembly including a housing for containing a propellant source, and a locking ring for attachment to the housing. The housing is configured to receive a flange of a syringe, the locking ring is configured to retain a syringe flange received in the housing between the locking ring and the housing when the locking ring is attached to the housing.

Abstract: A sub-assembly of a medicament delivery device, the sub-assembly comprising including a propellant source having a reservoir housing defining a reservoir and a stem having a bore therethrough, at least one inlet in fluid communication with the bore, and an open outlet end in fluid communication with the bore, the stein being moveable relative to the reservoir housing between a first position in which the at least one inlet is not in fluid communication with the reservoir and a second position in which the at least one inlet is in fluid communication with the reservoir, the propellant source further including a biasing member for biasing the stem towards the first position. The sub-assembly further including a collet member having a first plurality of radially flexible fingers and a second plurality of radially flexible fingers.

Abstract: A medicament delivery device includes a housing having a longitudinal axis, a container holder, an axially movable plunger adapted to be displaced along the longitudinal axis into the container holder, and an energy accumulating member arranged inside the housing and adapted for displacing the plunger along the longitudinal axis. The plunger includes an outer plunger rod and an inner plunger rod arranged at least partially inside the outer plunger rod, the inner plunger rod being threadedly engaged with the outer plunger rod and manually rotatable to displace the inner plunger rod along the longitudinal axis into the container holder.

Abstract: A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

Abstract: A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

Abstract: A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

Abstract: A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

Abstract: A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

Abstract: A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

Abstract: A housing blank and an activation member blank for a medicament delivery device are disclosed, with a kit including a housing blank and an activation member blank, and a medicament delivery device assembled from the kit. The housing blank includes a mid portion having a through-opening for receiving a proximal end portion of a medicament container assembly, and first and second legs foldable relative to the proximal end portion. The activation member blank includes a central portion and a first and second arm foldable relative to the proximal end portion.

Abstract: An assembly for a drug delivery device is presented. The assembly comprises a housing and a piston rod having a longitudinal axis, a distal end and a proximal end. The piston rod further comprises a piston rod interaction feature, and a piston rod guide being movable with respect to the piston rod, the piston rod guide further comprising a guide interaction feature corresponding to the piston rod interaction feature, the piston rod guide being movable with respect to the piston rod to switch between a first state and a second state of the assembly, the second state being different from the first state.

Abstract: In a conventional laminated gasket production method, when a product of a laminated gasket is demolded from a mold, the product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the laminated gasket. These minute scratches are liable to prevent reliable sealing of a liquid drug. The present invention is a method for producing a gasket to be used for a medical syringe and is characterized by including the steps of: preparing a gasket molding mold; molding a gasket having a circumferential surface portion in the mold with the gasket being laminated with a lamination film; and demolding the gasket from the mold, and then forming a groove only in the lamination film circumferentially of the circumferential surface portion of the gasket.

Abstract: A medicament delivery device includes a housing having proximal and distal ends; a hollow piston plunger within the housing; a telescopic dose drum concentric between the housing and the plunger; and a plunger driver to drive the plunger toward the proximal end having a hollow drive drum sleeve movable within and coupleable to the piston plunger and fixed to the dose drum; an actuator operably connected to the drive drum sleeve; and a stop body for inhibiting rotation of the dose drum and drive drum sleeve when a set dose equals a remaining dose in a medicament container. The drive drum sleeve and piston plunger are operatively coupled such that axial movement of the actuator toward the proximal end forces the drive drum sleeve and piston plunger to couple, whereby the piston plunger and dose drum are displaced toward the proximal end for delivering the set dose.

Abstract: A drug delivery device comprises a lead screw having a longitudinal axis, a distal end and a proximal end that is axially movable in a distal direction relative to a mid-body, the lead screw including a threaded shaft, wherein the lead screw has a keyway positioned parallel to the longitudinal axis and containing a first section of a dose dispensing feedback component; the mid-body being designed to prevent rotation of the lead screw with respect to the mid-body, where the mid-body contains a second section of the dose dispensing feedback component.

Abstract: A method and an assembly for providing a drug delivery device is presented. The assembly includes a housing and an end of dose feedback connection provides the user with an audible and/or tactile signal to indicate that the drug delivery is completed. A first section of the end of dose feedback connection is located on a distal portion of an inner sleeve and a second section of the end of dose feedback connection is located on the mid-body.

Abstract: A sensor assembly comprising a first rotary sensor part having a plurality of individual electrically conducting code segments arranged in a circumferential pattern, and a plurality of electrically conducting reference segments between the code segments, and a second rotary sensor part arranged rotationally relative to the first part a plurality of contact structures, each contact structure being arranged to be in contact with either a code segment or a reference segment depending on the rotational position between the first and second rotary sensor part. The contact structures are configured to engage and connect to different sensor segments as the first and second rotary sensor part rotate relative to each, the created connections being indicative of a rotational position between the first and second rotary sensor part. For a given rotational position, at least one contact structure engages a code segment and at least one contact structure engages a reference segment.

Abstract: A device for injecting a medicament includes a housing for a medicament container assembly, and an activation member axially movable relative to the housing between extended and retracted positions with a gripping member. A movement guide mechanism includes a first guide, a second guide that has a locking portion, and a guide follower that slides along the first guide when the activation member moves from the extended position to the retracted position and that slides along the second guide when the activation member moves from the retracted position to the extended position. The gripping member engages the container assembly when the activation member is in the retracted position. The locking portion interacts with the guide follower when the activation member moves from the retracted position to the extended position to restrict movement of the activation member. A method of assembling a delivery device is also disclosed.

Abstract: A member (1) for a drug delivery device is provided, the member comprising a main body (10), an interaction section (13) and a resilient section (12). Moreover, the main body (1) is unitarily formed with the resilient section (12) and the interaction section (13), wherein the resilient section (1) connects the main body (10) and the interaction section (13), and wherein the interaction section (13) comprises a clicker feature (14).

Abstract: A sensor assembly comprising a first rotary sensor part with a plurality of individual electrically conducting axial position sensor segments arranged in a circumferential pattern, and a second rotary sensor part arranged rotationally relative to the first portion and comprising a plurality of circumferentially arranged electrically interconnected axial position contacts adapted to be arranged in contact with the axial position sensor segments. The assembly further comprises actuator means for axially moving the axial position contacts between a connected and a dis-connected position, wherein the axial position contacts and the axial position sensor segments are arranged such that for a given rotational position at least two axial position contacts each are in contact with a different axial position sensor segment.

Abstract: Drug delivery device comprising expelling means allowing a user to set a dose corresponding to a number of increments from an initial state, an indication member adapted to rotate in a first direction corresponding to the set dose, and rotate in an opposed second direction corresponding to an expelled dose, the indication member having an initial rotational position corresponding to both the initial state and the fully expelled dose state. Sensor means having an incremental counter synchronized with the rotational position of the indication member and having a reference point corresponding to the initial rotational position of the indication member. After detecting an error state the sensor means is adapted to re-synchronize by detecting the number of rotational increments for a set dose and for a subsequent expelled dose. If the numbers are identical the reference point is reset corresponding to the current rotational position of the indication member.

Abstract: A dedicated device for detection of vascular shunts can include a first chamber, a second chamber, and a third chamber. The first chamber can be configured to hold liquid, the second chamber to hold gas, and the third chamber can be in communication with the first and second chambers. The third chamber can include small-scale geometric features configured to produce gas bubbles as liquid from the first chamber and gas from the second chamber simultaneously flow into the third chamber. The device can also include a device opening in communication with the third chamber such that a mixture of liquid and gas bubbles can flow out of the device opening. The device can also include a plunger configured to force the liquid and the gas simultaneously from the first and second chambers, through the third chamber to mix with each other and produce bubbles, and further through the device opening.