Patents Issued in October 6, 2016
  • Publication number: 20160287860
    Abstract: A resuscitation system that includes at least two defibrillation electrodes configured to be applied to the exterior of the chest of a patient for delivering a defibrillation shock, a source of one or more ECG signals from the patient, a defibrillation circuit for delivering a defibrillation shock to the defibrillation electrodes, a control box that receives and processes the ECG signals to determine whether a defibrillation shock should be delivered or whether CPR should be performed, and that issues instructions to the user either to deliver a defibrillation shock or to perform CPR, wherein the determination of whether CPR should be performed and the instructions to perform CPR can occur at substantially any point during a rescue.
    Type: Application
    Filed: January 28, 2016
    Publication date: October 6, 2016
    Inventor: Gary A. Freeman
  • Publication number: 20160287861
    Abstract: A surgical tool including first connecting elements, contacting elements, and conductive elements. The contacting elements are configured to contact nerve tissue of a patient. The conductive elements extend from the connecting elements to the contacting elements. The conductive elements have respective insulative outer layers. The insulative outer layers isolate the conductive elements from each other. The first connecting elements are configured to connect to and receive monophasic stimulation pulses from second connecting elements on a modular stimulation module. The modular stimulation module is configured to connect to the tool and other tools via the second connecting elements. The conductive elements are configured to transfer the monophasic stimulation pulses from the connecting elements to the contacting elements.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 6, 2016
    Inventors: Kevin L. MCFARLIN, Bryan L. COURTNEY, Matthew L. CANTWELL
  • Publication number: 20160287862
    Abstract: The disclosure relates to a lead including a connector for connection to a generator, a demultiplexing circuit receiving at its input on the first conductors of the electrical control signals from the control bus and whose output is connected to a plurality of second conductors contained in the lead and connected to the lead electrodes. The lead further includes a gate and connection circuit component having a body forming a support for an integrated circuit for demultiplexing and defining a set of connection cavities with the second conductor distributed at the periphery of the body around a general axis of the body, and a plurality of connecting elements embedded in the body material, and emerging at an element region and supporting the circuit at respective cavities. The gate and connection circuit component is advantageously made of ceramic-metal.
    Type: Application
    Filed: April 1, 2016
    Publication date: October 6, 2016
    Inventors: Nicolas Shan, Philippe D'Hiver
  • Publication number: 20160287863
    Abstract: Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 6, 2016
    Inventors: Andre MERCANZINI, Philippe RENAUD
  • Publication number: 20160287864
    Abstract: In some examples, a lead identification system includes a first set of first lead indicators and a second set of second lead indicators. Each of the first lead indicators is configured to removably attach to at least one of a first therapy delivery element, a first epidural needle, or a first connector to uniquely identify at least one of the first therapy delivery element, the first epidural needle, or the first connector during implantation of the first therapy delivery element in the patient. Each of the second lead indicators is configured to removably attach to at least one of a second therapy delivery element, a second epidural needle, or a second connector to uniquely identify at least one of the second therapy delivery element, the second epidural needle, or the second connector during implantation of the second therapy delivery element in the patient.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 6, 2016
    Inventors: Richard North, Scott F. Drees, John M. Swoyer, Lawrence Kane, Jesse Geroy, Shahn S. Sage, Elliot W. Bridgeman, James Finley
  • Publication number: 20160287865
    Abstract: Implantable medical devices comprising electromagnetic interference shields which incorporate a dump resistor and various enhancements to control high voltage arcing. Included are embodiments in which a dump resistor is provided in a flexible shield having first and second conductive layers, where the resistor is provided in a layer between the conductive layers. In additional examples the design of plated through-holes is done to avoid the potential for arcing while maintaining close spacing.
    Type: Application
    Filed: January 18, 2016
    Publication date: October 6, 2016
    Applicant: CARDIAC PACEMAKERS, INC.
    Inventors: Jean M. Bobgan, James E. Blood, Moira B. Sweeney, Ron A. Balczewski, William J. Linder
  • Publication number: 20160287866
    Abstract: A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.
    Type: Application
    Filed: June 9, 2016
    Publication date: October 6, 2016
    Inventors: Thomas Jerome Bachinski, Richard Paul Shindley, Dennis Lutz
  • Publication number: 20160287867
    Abstract: Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used the treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 6, 2016
    Applicant: RM2 TECHNOLOGY LLC
    Inventors: Boris Rubinsky, Paul Mikus, Liel Rubinsky
  • Publication number: 20160287868
    Abstract: The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise a complete wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.
    Type: Application
    Filed: March 31, 2015
    Publication date: October 6, 2016
    Applicants: The United States Government, as represented by the Department of Veterans Affairs, Case Western Reserve University
    Inventors: Kath M. Bogie, Steven L. Garverick, Christian A. Zorman, Daniel S. Howe
  • Publication number: 20160287869
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 6, 2016
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Publication number: 20160287870
    Abstract: In one aspect, the disclosure features systems for providing auditory signals to a subject. The systems include a sensor front-end circuit configured to be connected to an acoustic sensor and to convert analog signals received from the acoustic sensor to digital electric signals. The systems further include a sound processor circuit configured to be connected to the sensor front-end circuit and receive the electric signals provided by the sensor front end circuit. The sound processor includes multiple filters that spectrally decompose the received electrical signals into multiple spectral channels during operation of the system. The multiple spectral channels include at least a low frequency channel and a high frequency channel and the sound processor circuit is configured to operate the low frequency channel at a sample rate lower than a sample rate of the high frequency channel.
    Type: Application
    Filed: November 25, 2014
    Publication date: October 6, 2016
    Inventors: Marcus Yip, Anantha Chandrakasan, Konstantina Stankovic
  • Publication number: 20160287871
    Abstract: A method of modeling time-dependent electrical activity of a biological system, the method comprises transforming an input through at least one dynamic mode to yield at least one modal output; processing the at least one modal output to yield at least one amplitude variable and at least one phase variable; and mapping the at least one amplitude variable and the at least one phase variable to an observable output.
    Type: Application
    Filed: April 18, 2016
    Publication date: October 6, 2016
    Inventors: Berj L. BARDAKJIAN, Osbert C. ZALAY
  • Publication number: 20160287872
    Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Application
    Filed: April 5, 2016
    Publication date: October 6, 2016
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker, Yougandh Chitre, Sangsoo Wesley Park, James R. Thacker
  • Publication number: 20160287873
    Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Application
    Filed: April 5, 2016
    Publication date: October 6, 2016
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker, Yougandh Chitre, Sangsoo Wesley Park, James R. Thacker
  • Publication number: 20160287874
    Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Application
    Filed: April 5, 2016
    Publication date: October 6, 2016
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker, Yougandh Chitre, Sangsoo Wesley Park, James R. Thacker
  • Publication number: 20160287875
    Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 kHz to about 100 kHz may be applied to the patient's spinal cord region to address abdominal pain without creating paresthesia in the patient.
    Type: Application
    Filed: April 6, 2016
    Publication date: October 6, 2016
    Inventors: James R. Thacker, Konstantinos Alataris, Bradford Evan Gliner
  • Publication number: 20160287876
    Abstract: The disclosure relates to a device including a plurality of electrodes for stimulation of both ventricles with application of an atrioventricular delay and of an interventricular delay, a processor configured to multidimensionally measure an interventricular conduction delay, and monitor the evolution of a patient's condition. For the multidimensional measurement of the interventricular conduction delay, the device produces stimulation of one of the ventricles and collects, in the other ventricle, two endocardial electrogram signals on separate respective channels, giving two respective temporal components. Both temporal components are combined in one single parametric 2D characteristic representative of the cardiac cycle, and a comparison is made with reference descriptors for deriving an index representative of the evolution of the patient's condition.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 6, 2016
    Inventors: Marie-Anne Euzen, Paola Milpied
  • Publication number: 20160287877
    Abstract: Adaptive systems and methods for automatically determining and continuously updating stimulation parameters for adjusting ventilation to accommodate a patient's specific physiology, metabolic needs, and muscle state are disclosed herein. Having a closed loop implementation, the system may comprise a controller including a neuromorphic controlled adaptive feed-forward Pattern Generator/Pattern Shaper (PG/PS) assembly, which controls respiratory muscle movement using electrical stimulation. This PG/PS assembly comprises a biomimetic design where the pattern generator includes a neural network mimicking the simplified connectivity pattern of respiratory related neurons in the brain stem to produce a rhythmic breathing pattern frequency and the pattern shaper includes a neural network mimicking the simplified connectivity pattern of neurons to produce a stimulus control signal.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 6, 2016
    Applicant: The Florida International University Board of Trustees
    Inventor: Ranu JUNG
  • Publication number: 20160287878
    Abstract: Electrical stimulation is applied to a patient at least in part via a pulse generator. A motor fiber component of an action potential that is evoked in response to the electrical stimulation is measured. A sensory fiber component of the action potential is also measured. A relationship between the motor fiber component and the sensory fiber component is determined. For example, a ratio between the sensory fiber component and the motor fiber component may be calculated, or the absolute sizes of the sensory fiber component and the motor fiber component may be compared. Based on the determined relationship between the motor and sensory fiber components, a paresthesia of the patient is estimated.
    Type: Application
    Filed: June 13, 2016
    Publication date: October 6, 2016
    Inventors: Kerry Bradley, Leslie Halberg
  • Publication number: 20160287879
    Abstract: In some examples, a phase locked loop (PLL) circuit outputs a timing signal having a frequency and phase that is the same as a patient signal that is an input to the PLL circuit. The PLL circuit includes or is coupled to a storage circuit that stores information needed to cause the PLL circuit to maintain the frequency of the timing signal to the same frequency even after the patient signal is not available as an input.
    Type: Application
    Filed: March 16, 2016
    Publication date: October 6, 2016
    Inventors: Timothy J. Denison, Scott R. Stanslaski
  • Publication number: 20160287880
    Abstract: Implantable medical devices including interconnections having strain-relief structure. The interconnections can take the form of flexible circuits. Strain relief gaps and shapes are integrated in the interconnections to relieve forces in each of three dimensions. In some examples, the region of an interconnection which couples with a component of the implantable medical device is separated by a strain relief gap from a connection to a second component and/or a location where the flex bends around a corner.
    Type: Application
    Filed: March 2, 2016
    Publication date: October 6, 2016
    Applicant: CARDIAC PACEMAKERS, INC.
    Inventors: Jean M. Bobgan, Moira B. Sweeney, James E. Blood, Robert A. Jones, John E. Hansen, Keith R. Maile
  • Publication number: 20160287881
    Abstract: Couplings for implanted leads and external stimulators, and associated systems and methods are disclosed. A connector in accordance with a particular embodiment includes a first housing portion and a second housing portion pivotably connected to each other. The first housing portion has an elongated fixed stop opening. The second housing portion has a stop element and a plurality of connector contacts positioned to electrically contact a plurality of connection contacts of a spinal cord stimulation lead. The first and second housing portions are pivotably connected to each other to move between a partially-opened position in which the stop element is in a first location in the elongated fixed stop opening, and a closed position in which the stop element has a second location in the elongated fixed stop opening.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 6, 2016
    Inventors: Apratim N. Dixit, Vivek Sharma, Andre B. Walker
  • Publication number: 20160287882
    Abstract: The invention relates to a feedthrough device especially for a medical implant system, comprising: a flexible substrate locally comprising at least one means for stiffening the substrate, said at least one stiffening means having a through-opening; and at least one hermetic feedthrough comprising an electrical connection element, said feedthrough being hermetically joined to a stiffening means, such that said electrical connection element passes through the through-opening.
    Type: Application
    Filed: November 12, 2014
    Publication date: October 6, 2016
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Nicolas Karst, Fabrice Emieux, Simon Perraud
  • Publication number: 20160287883
    Abstract: An encapsulated filtered feedthrough assembly for an implantable medical device including a ferrule, an electrical insulator coupled to the ferrule, a printed circuit board (PCB), a feedthrough conductor extending through the electrical insulator and the PCB, and a capacitor coupled to the PCB. The encapsulated filtered feedthrough assembly can include a mold defining an opening and located with respect to the printed circuit board such that at least a portion of the capacitor is positioned within the opening. A first non-conductive material can underfill the capacitor and a second non-conductive material can be backfilled into the mold to encapsulate the capacitor.
    Type: Application
    Filed: March 24, 2016
    Publication date: October 6, 2016
    Inventors: Patrick J. Barry, Randy White, Steven A. Kubow, Scott A. Spadgenske, David A. Chizek, Jerald Sauber
  • Publication number: 20160287884
    Abstract: Improved assemblies, systems, and methods provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system includes an implantable pulse generator and a lead sized and configured to be implanted subcutaneously in a tissue region. An external controller includes circuitry adapted for wireless telemetry and a charging coil for generating the radio frequency magnetic field to transcutaneously recharge a rechargeable battery in the pulse generator. Using wireless telemetry, the pulse generator is adapted to transmit status information back to the external controller to allow the external controller to automatically adjust up or down the magnitude of the radio frequency magnetic field and/or to instruct a user to reposition the charging coil, the status information adapted to allow optimal recharging of the pulse generator rechargeable battery.
    Type: Application
    Filed: March 7, 2016
    Publication date: October 6, 2016
    Inventors: Robert B. Strother, Geoffrey B. Thrope, Danny R. Pack
  • Publication number: 20160287885
    Abstract: Devices, systems, and methods for neuromodulation are provided. For example, a neuromodulation system is disclosed that comprises an implantable neuromodulation module having a photodiode configured to generate electrical current in response to receiving light from an optical fiber; an optical transceiver; and at least one electrode configured to provide electrical stimulation to a nerve utilizing the electrical current generated by the photodiode. As another example, a method of neuromodulation is disclosed that comprises receiving light at a photodiode of a neuromodulation module and generating electrical current in response to receiving the light; and providing, via at least one electrode of the module positioned within the patient, electrical stimulation to a nerve of the patient utilizing the electrical current generated by the photodiode.
    Type: Application
    Filed: April 6, 2016
    Publication date: October 6, 2016
    Inventor: RAHUL SAINI
  • Publication number: 20160287886
    Abstract: Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 6, 2016
    Inventors: Jordi Parramon, Goran N. Marnfeldt, Robert Ozawa, Emanuel Feldman, Dave Peterson, Yuping He
  • Publication number: 20160287887
    Abstract: Systems and methods are provided for bridging a bi-directional communication link between an external device and an implantable medical device (IMD). The systems and methods establish a first bi-directional communication link between an external device and a wireless bridge device according to a wireless protocol, and establish a second bi-directional communication link between the wireless bridge device and an IMD concurrently with the first bi-direction communication link according to the wireless protocol. The systems and methods further receive a data packet from the external device at the wireless bridge device. The data packet is received during the communication interval. The systems and methods further transmit the data packet from the wireless bridge device to the IMD during the communication interval.
    Type: Application
    Filed: April 1, 2015
    Publication date: October 6, 2016
    Inventors: Yonjian Wu, Reza Shahandeh, Samir Shah, Chao-Wen Young, Mostafa Sadeghi, Jun Yang, Thanh Tieu
  • Publication number: 20160287888
    Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
    Type: Application
    Filed: April 5, 2016
    Publication date: October 6, 2016
    Inventors: Konstantinos Alataris, Andre B. Walker, Jon Parker, Yougandh Chitre, Sangsoo Wesley Park, James R. Thacker
  • Publication number: 20160287889
    Abstract: A method and system include a processor that outputs a characterization of a correspondence between a volume of estimated tissue activation and a target and/or side effect stimulation volume, and/or that provides controls by which to modify thresholds and/or amounts according to which the volume of estimated activation is to correspond to the target volume.
    Type: Application
    Filed: June 13, 2016
    Publication date: October 6, 2016
    Inventors: Hemant Sharad Bokil, Mark Pierre, Keith R. Carlton, Michael A. Moffitt, Richard Mustakos, Dean Chen
  • Publication number: 20160287890
    Abstract: An external defibrillator system is disclosed that generates and applies a diagnostic signal to the patient in conjunction with defibrillation therapy. The diagnostic signal is designed to elicit a physiologic response from the patient's heart, namely, mechanical cardiac response and electrical cardiac response, electrical cardiac response only, or no cardiac response. Depending upon the type of cardiac response detected, the system selects an appropriate resuscitation protocol that considers the likely responsiveness of the patient to defibrillation therapy. In one practical embodiment, a stimulus signal is applied to patients that show mechanical and electrical capture in response to the diagnostic signal. The stimulus signal maintains the mechanical capture (and, therefore, perfusion) for a period of time prior to the delivery of a defibrillation pulse.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 6, 2016
    Inventors: David R. Hampton, Isabelle Banville
  • Publication number: 20160287891
    Abstract: A high frequency cancer thermotherapy apparatus treats by generating a high frequency electric field between a pair of electrode parts which sandwich a patient and are disposed so as to be opposite to each other and performing a dielectric heating with respect to an affected part. The apparatus includes a bed having a bed part and a bed supporting part for liftably/lowerably and horizontally movably supporting the bed part, a gantry on which the electrode parts are mounted, and a high frequency generation and control part. A maximum-sized electrode part which can be mounted on the gantry includes an electrode plate having a diameter exceeding 300 mm and a pad attached on the electrode plate. The bed part includes an opening part formed such that the maximum-sized electrode part can pass from a vertical direction, a shutter which opens/closes the opening part, and a bed surface flatization device.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 6, 2016
    Applicant: SHONAI CREATE INDUSTRIAL CO., LTD.
    Inventors: Masanori SUZUKI, Hiroaki IKEHARA
  • Publication number: 20160287892
    Abstract: An assembly for the treatment of wounds comprising a device for generating a plasma, or an excited gas or gas mixture, respectively. A covering is used to cover a wound area. A first conduit connects the device and the covering and a second conduit connects the covering and a pump. The device is arranged within a housing comprising an opening. The device comprises a piezoelectric transformer having a high-voltage end for generating the plasma, and is arranged within the housing such that the high-voltage end is directed towards the opening. The plasma or the excited gas or gas mixture, respectively, is generated in a region of the opening of the housing. A wound cover comprising a means for guiding the plasma across the wound area is arranged between the covering and the wound area.
    Type: Application
    Filed: June 9, 2016
    Publication date: October 6, 2016
    Inventors: Stefan Nettesheim, Dariusz Korzec, Dominik Burger
  • Publication number: 20160287893
    Abstract: A method of treating a patient, involving a) injecting a flowable material into a cancellous bone region of a bone, wherein the material is adapted to facilitate tissue regeneration, and b) irradiating the cancellous bone region with an effective amount of NIR/red light. The irradiation may be carried out from a light source located inside the bone. The light may enter the bone via a transmitter located underneath the skin of the patient.
    Type: Application
    Filed: June 7, 2016
    Publication date: October 6, 2016
    Applicant: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Mohamed Attawia, Thomas M. DiMauro, Jeffrey K. Sutton
  • Publication number: 20160287894
    Abstract: Provided are a medical instrument capable of operating the entire treatment target site with a single irradiation. The medical instrument is inserted into a living body and performs light irradiation on the treatment target site. The medical instrument includes a lengthy medical instrument body having at least one of lumens, and in the medical instrument body, lengthy light diffusers, and a lengthy reflector having a reflection surface for reflecting light, each being inserted to be extended along the longitudinal direction. The medical instrument body includes a transparent outer wall portion that is optically transparent and extended along the longitudinal direction. The light diffusers includes an irradiation section for irradiating light on the treatment target site and a light receiving section for receiving light from the treatment target site, the light diffusers being arranged to face the reflection surface and the transparent outer wall portion.
    Type: Application
    Filed: November 6, 2014
    Publication date: October 6, 2016
    Applicant: Arai MedPhoton Research Laboratories, Corporation
    Inventors: Tsunenori ARAI, Arisa ITO, Takehiro KIMURA
  • Publication number: 20160287895
    Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
    Type: Application
    Filed: May 12, 2016
    Publication date: October 6, 2016
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru
  • Publication number: 20160287896
    Abstract: Methods and apparatuses for phototherapy to treat skin disorders. In particular, described herein are phototherapy dressings for use with phototherapy UV light applicators (sources) to treat skin disorders such as psoriasis. The dressings described herein may include a support body onto which a medicament formed of a hydrogel and coal tar and/or coal tar extract is held. The dressing may be configured so that at least half (50%) of the UV light within a therapeutic range of wavelengths is through the dressing including the medicament to the patient's skin. The dressings may be adapted for use in conjunction with a phototherapy UV light sources.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 6, 2016
    Inventors: Evan ANDERSON, Christopher PELL, Stephen DUGAN, Adam MARTOS
  • Publication number: 20160287897
    Abstract: Systems and methods for adjusting the amount of power supplied to light sources in a phototherapy panel are configured to maintain irradiance at a level that corresponds to a recommended level. By virtue of such adjustments, infants with jaundice can be treated and/or a notification that the light sources need to be replaced maybe determined.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 6, 2016
    Inventor: Siegfried Walter KAESTLE
  • Publication number: 20160287898
    Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 6, 2016
    Inventors: Joseph T. Smith, Michael Goryll, Dixie Kullman, Jitendran Muthuswamy, Jennifer Blain Christen
  • Publication number: 20160287899
    Abstract: Provided herein is an integrated target structure for generating charged particles. The integrated target structure according to an embodiment of the present disclosure includes a target layer emitting charged particles depending on an irradiation of a laser beam, an optical component controlling at least one of the laser beam and the charged particles, and a support body supporting the target layer and the optical component using one structure.
    Type: Application
    Filed: March 28, 2016
    Publication date: October 6, 2016
    Inventors: Hyung Ju PARK, Moon Youn JUNG, Won Bae CHO, Ji Su LEE
  • Publication number: 20160287900
    Abstract: Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.
    Type: Application
    Filed: May 11, 2016
    Publication date: October 6, 2016
    Inventors: Charles R. Quirico, Ernest Balestracci, Rolf E. Swenson, Daniel D. Darst, Eric J. Krause, Vishal N. Lokhande, Jacob S. Childs
  • Publication number: 20160287901
    Abstract: Surgical cavity sizers for selecting a radiation applicator for brachytherapy and intraoperative radiation therapy. The surgical cavity sizer has a head portion and a handle portion monolithic to the head portion. The surgical cavity sizer is composed of biocompatible and sterilizable material. A method for selecting a radiation applicator as well as a container for a surgical cavity sizer and/or a radiation applicator are also disclosed.
    Type: Application
    Filed: November 7, 2014
    Publication date: October 6, 2016
    Inventors: Frederic Dumaine, Jan Seuntjens, Monica Serban, Marija Popovic
  • Publication number: 20160287902
    Abstract: A guide member facilitates a device swap for brachytherapy treatment. A cavity evaluation device is introduced during surgery such that a distal end of the device is disposed in a resected cavity of the patient. The cavity evaluation device includes a shaft in which is disposed an elongated guide member. In a subsequent out-patient procedure the cavity evaluation device is removed from the resected cavity. If a brachytherapy treatment is to be performed then the cavity evaluation device is removed without removing the elongated guide member such that position of a portion of the elongated guide member in the resected cavity is maintained relative to the resected cavity. An anchor member helps to maintain the position of the guide member. Introduction of a brachytherapy catheter is then facilitated by introducing the elongated guide member into an opening of the brachytherapy catheter and using the elongated guide member to guide the brachytherapy catheter to the resected cavity.
    Type: Application
    Filed: May 27, 2016
    Publication date: October 6, 2016
    Applicant: Hologic, Inc.
    Inventor: Maria Benson
  • Publication number: 20160287903
    Abstract: A computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: assuming an activity retention limit; utilizing the activity retention limit to determine a dose rate for a phantom category; utilizing the dose rate for the phantom category to determine the dose rate for a second phantom category; and utilizing the dose rate for a second phantom category to find information regarding the second phantom category. In other embodiments, a computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: obtaining at least one image relating to anatomy of a particular patient; obtaining multiple images regarding radioactivity distribution over time in the particular patient; combining the radioactivity images with the anatomy images; running a Monte Carlo simulation to obtain dose image information; and using the dose image information to obtain BED and/or EUD information.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 6, 2016
    Inventors: George SGOUROS, Hong SONG, Andrew PRIDEAUX, Robert HOBBS
  • Publication number: 20160287904
    Abstract: A medical radiation device, including a main frame, and a radiation assembly and an imaging assembly respectively located at an end of the main frame. After an imaging scan is completed and diseased tissue positioning images are taken, a patient is directly moved to the other end of the main frame to allow the radiation assembly to perform a radiation treatment to improve the efficiency of the radiation treatment after the completion of diseased tissue positioning, and effectively reduce movement of the patient when the patient is being moved for radiation treatment after the imaging assembly completes diseased tissue positioning, thus reducing a positioning error of the diseased tissue caused by too much movement.
    Type: Application
    Filed: November 13, 2014
    Publication date: October 6, 2016
    Applicant: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Jian LIU, Jian ZHANG, Yuelin SHAO
  • Publication number: 20160287905
    Abstract: An irradiation device using ionizing radiation, particularly for radiation therapy and/or radiation biology, simultaneously includes: at least one unit (MER) for emitting ionizing radiation; at least one dose-monitoring unit (MCD); at least one unit for detecting an ionizing radiation dose (MDD); and at least one monitoring and control system (SCC). The units (MER, MDD, MCD) and the system (SCC) are also intelligently interconnected therebetween so as to engage with one another and form an intelligent monitoring and adjustment loop, such as to controllably, precisely and desirably produce strong doses of ionizing radiation of at least 0.01 Gy, having a precision within at least one 1 ?Gy but preferably 1 n Gy, in strong dose rates up to 1000 Gy/s with power within a range of 1 to 50 Me V in very brief time intervals of at least 0.1 ?s, preferably 1 ms.
    Type: Application
    Filed: November 20, 2014
    Publication date: October 6, 2016
    Inventor: Philippe LIGER
  • Publication number: 20160287906
    Abstract: Systems, devices, and methods for dosimetric verification of radiation therapy treatments by selective evaluation of measurement points. Systems, methods, and computer program-products for providing dosimetric verification of radiation therapy treatments by evaluating measurement points using different evaluation criteria.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 6, 2016
    Inventors: Janne NORD, Lasse Heikki TOIMELA
  • Publication number: 20160287907
    Abstract: The invention comprises a system for controlling a charged particle beam shape and direction relative to a controlled and dynamically positioned patient and/or an imaging surface, such as a scintillation plate of a tomography system and/or a first two-dimensional imaging system coupled to a second two-dimensional imaging system. Multiple interlinked beam/patient/imaging control stations allow safe zone operation and clear interaction with the charged particle beam system and the patient. Both treatment and imaging are facilitated using automated sequences controlled with a work-flow control system.
    Type: Application
    Filed: June 7, 2016
    Publication date: October 6, 2016
    Inventors: Susan L. Michaud, Stephen L. Spotts, James P. Bennett, W. Davis Lee
  • Publication number: 20160287908
    Abstract: The invention comprises a positively charged particle based cancer therapy system integrated with at least one off-axis imaging system, where elements of the off-axis imaging system and the cancer therapy system are co-positioned/co-rotated with a gantry. The imaging apparatus optionally functions with a tomography system using the positively charged particles of the cancer therapy system for enhanced patient/tumor imaging at and/or prior to a time of treatment.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 6, 2016
    Inventors: James P. Bennett, Stephen L. Spotts, W. Davis Lee, Susan L. Michaud
  • Publication number: 20160287909
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 6, 2016
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey