Patents Issued in October 11, 2016
  • Patent number: 9464117
    Abstract: Some embodiments of the present invention can include herbicide-resistant proteins, coding genes, and uses thereof. Certain herbicide-resistant proteins can comprises: (a) a protein consisting of an amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence at least 90% identical to that set forth in SEQ ID NO: 2. Other herbicide-resistant proteins of this disclosure can be suitable for expression in plants, can have resistance to herbicides (e.g., to phenoxy auxinherbicides), or both.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: October 11, 2016
    Assignees: BEIJING DABEINONG TECHNOLOGY GROUP CO., LTD, BEIJING DABEINONG TECHNOLOGY GROUP CO., LTD., BIOTECH CENTER, BEIJING GREEN AGROSINO PLANT PROTECTION TECHNOLOGY CO., LTD.
    Inventors: Yechun Wu, Qing Tao, Derong Ding, Dengyuan Wang, Haili Liu, Xiaoqian Song, Tiantian Xing, Liguo Du, Songsong Shang, Xiaoming Bao
  • Patent number: 9464118
    Abstract: The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: October 11, 2016
    Assignee: FORSCHUNGSZENTRUM JUELICH GMBH
    Inventors: Dieter Willbold, Susanne Aileen Funke, Oleksander Brener, Luitgard Nagel-Steger, Dirk Bartnik
  • Patent number: 9464119
    Abstract: The present invention relates to nucleic acids encoding the novel parvoviral protein “assembly activating protein” (AAP), the encoded polypeptides, methods of producing the polypeptides, antibodies specific for AAP, the use of the nucleic acids for the preparation of the polypeptides, the use of the nucleic acids or the polypeptides for the preparation of the parvoviral particle and methods of producing parvoviral particles essentially consisting of VP3. Furthermore, the invention relates to parvoviral particles essentially consisting of VP3 and/or obtainable by the above method as well as expression cassettes comprising (i) a heterologous promoter and (ii) VP3 coding sequence and/or fragment Z. The invention further relates to a medicament, particularly a vaccine, comprising the parvoviral particles or expression cassettes and their use.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: October 11, 2016
    Assignees: Deutsches Krebsforschungszentrum, Medigene AG
    Inventors: Florian Sonntag, Juergen Kleinschmidt, Markus Hoerer, Kerstin Lux
  • Patent number: 9464120
    Abstract: The invention provides agents and vaccines for treating and diagnosing celiac disease. In particular, the present invention provides a combination of three peptides that are useful for treating and diagnosing celiac disease in a large proportion of patients.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: October 11, 2016
    Assignee: ImmusanT, Inc.
    Inventors: Robert P. Anderson, Jessica A. Stewart, James A. Dromey, Jason A. Tye-Din
  • Patent number: 9464121
    Abstract: The present invention features compositions and methods for the treatment of erectile dysfunction. The compositions include substantially pure polypeptides derived from ?-latrotoxin and can include other substances, such as pharmaceutically acceptable carriers or diluents, liposomes, hydrogels, and additional active ingredients for the treatment of erectile dysfunction. Also provided are methods, including methods for using the compositions for treatment of erectile dysfunction and in the preparation of medicaments.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: October 11, 2016
    Assignees: UNIVERSIDAD DE LA FRONTERA, UNIVERSIDAD FEDERAL DE SAO PAULO, LABORATORIOS ANDROMACO S.A.
    Inventors: Fernando Gonzalo Romero Mejia, Raul Patricio Salvatici Salazar, Antonio Miranda
  • Patent number: 9464122
    Abstract: Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: October 11, 2016
    Assignee: Oligomerix, Inc.
    Inventors: James G. Moe, Eliot J. Davidowitz
  • Patent number: 9464123
    Abstract: Peptides having activity of inhibiting infections of respiratory viruses and use of the same are disclosed. The peptides can be synthesized by chemical or genetic engineering methods, and they have functional domain capable of binding to surface glycoprotein of respiratory viruses and activity of inhibiting infections of respiratory viruses. The peptides are useful for blocking infections of respiratory viruses in target cells, for prevention/treatment of said infections, and for development of new prophylactic/therapeutic medicaments against respiratory viruses. Also disclosed are a kit for screening peptide capable of inhibiting said infections and the screening method. The invention also discloses the mechanism of the peptides in inhibition of said infections, which provides theory support for developing new prophylactic/therapeutic agents with broad-spectrum antiviral activities.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: October 11, 2016
    Assignee: XIANGXUE GROUP (HONG KONG) COMPANY LIMITED
    Inventors: Bojian Zheng, Hanjun Zhao
  • Patent number: 9464124
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 11, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Jason P. Schrum, Alexander Aristarkhov
  • Patent number: 9464125
    Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: October 11, 2016
    Assignee: The Trustees of Princeton University
    Inventors: A. James Link, Siyan Zhang
  • Patent number: 9464126
    Abstract: The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF21 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the ?Klotho-FGF receptor complex involving the use of chimeric proteins of the present invention.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 11, 2016
    Assignee: New York University
    Inventors: Moosa Mohammadi, Regina Goetz
  • Patent number: 9464127
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: October 11, 2016
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • Patent number: 9464128
    Abstract: The present invention relates to site-specific PEGylated linear salmon calcitonin analogs, or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical compositions comprising them, and their use for the preparation of a medicament for the treatment or prevention of diseases associated with bone metabolism, e.g., osteoporosis.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: October 11, 2016
    Assignee: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A.
    Inventors: Keliang Liu, Jiankun Qie, Zhixia Yang, Yuanjun Liang, Ying Wang, Zehui Gong, Huajin Dong
  • Patent number: 9464129
    Abstract: The invention relates to peptides of general formula (I): R1-AA-R2??(I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1 is H or acetyl, R2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: October 11, 2016
    Assignee: BCN PEPTIDES S.A.
    Inventors: Cristina Carreño Serraïma, Berta Ponsati Obiols, Wim Van Den Nest, Jimena Fernandez Carneado, Antonio Ferrer Montiel, Juan Cebrian Puche, Nuria Almiñana Domenech
  • Patent number: 9464130
    Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: October 11, 2016
    Assignee: The Regents of the University of California
    Inventors: David Julius, David D. McKemy, Werner M. Neuhausser
  • Patent number: 9464131
    Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 11, 2016
    Assignees: Theraclone Sciences, Inc., The Scripps Research Institute, International AIDS Vaccine Initiative
    Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Marjorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
  • Patent number: 9464132
    Abstract: A nanoantibody specifically binding surface antigen of Chlamydia trachomatis and having SEQ ID NO:2 amino acid sequence is disclosed. A nanoantibody specifically binding surface antigen of Chlamydia trachomatis and having SEQ ID NO:4 amino acid sequence is disclosed. A nanoantibody with SEQ ID NO:2 amino acid sequence inhibits development of Chlamydia infection caused by C. trachomatis. A nanoantibody with SEQ ID NO:4 amino acid sequence inhibits development of Chlamydia infection caused by C. trachomatis. A method of in vitro inhibiting a Chlamydia infection caused by C. trachomatis has the steps of pretreating elementary bodies of C. trachomatis by a therapeutically efficient amount of a nanoantibody specifically binding to a surface antigen of Chlamydia trachomatis, the nanoantibody comprising an amino acid sequence SEQ ID NO: 4 or SEQ ID NO:4, and then adding the elementary bodies of C. trachomatis to target cells being infected.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: October 11, 2016
    Assignee: Obschestvo s ogranichennoi otvetstvennostyu “Tekhnopharma”
    Inventors: Nailya A. Zigangirova, Sergey V. Tillib
  • Patent number: 9464133
    Abstract: Provided is a pharmaceutical composition for the treatment and/or prophylaxis of abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: October 11, 2016
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Yoshiharu Hiruma, Takako Kimura, Hironari Shimizu
  • Patent number: 9464134
    Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: October 11, 2016
    Assignee: ZYMOGENETICS, INC.
    Inventors: Katherine E. Lewis, Scott R. Presnell, Steven D. Levin, Robert Mabry, Stephen R. Jaspers, Monica J. Huber
  • Patent number: 9464135
    Abstract: Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or function of EMP2 to subjects at risk of the detachment.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: October 11, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA DEPARTMENT OF VETERAN AFFAIRS
    Inventors: Lynn K. Gordon, Shawn A. Morales, David Telander, Jonathan Braun
  • Patent number: 9464136
    Abstract: The present invention features antibody-based constructs that include a combination of two or more of a tetrameric antibody, a single chain antibody, a diabody, a triabody, another immunoglobulin-based moiety, as described herein, or biologically active variants thereof.
    Type: Grant
    Filed: August 20, 2011
    Date of Patent: October 11, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Karl Dane Wittrup, Jamie B. Spangler, Benjamin E. Epstein, Brian L. Ross
  • Patent number: 9464137
    Abstract: The invention relates to a composition comprising a glycoprotein comprising the Fc domain of an antibody, or a fragment thereof, comprising an Asn (asparagine) residue and an oligosaccharide structure attached thereto, wherein said oligosaccharide structure has a structure according to formula I; and wherein at least 20% of the oligosaccharide structures attached to glycoprotein in the composition consist of oligosaccharide structures according to formula (I).
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: October 11, 2016
    Assignee: Glykos Finland Oy
    Inventors: Tero Satomaa, Juhani Saarinen, Jari Natunen, Anja Vilkman, Heidi Virtanen, Jukka Hiltunen
  • Patent number: 9464138
    Abstract: The present invention relates to a method for producing a domain antibody in a yeast, wherein the formation of disulfide bridges in the domain antibody is promoted. The method encompasses the addition of oxidizing agents, preferably oxidizing metal ions, preferably one or more selected from Cu2+, Fe2+, Fe3+ and Zn2+.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: October 11, 2016
    Assignee: Ablynx N.V.
    Inventors: Peter Schotte, Patrick Stanssens, Christine Labeur, Jean-Luc Jonniaux, Marc Jozef Lauwereys
  • Patent number: 9464139
    Abstract: Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: October 11, 2016
    Assignee: AMGEN INC.
    Inventors: Courtney Beers, Jason C. O'Neill, Ian Foltz, Randal R. Ketchem, Julia C. Piasecki
  • Patent number: 9464140
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 11, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Bruce L. Levine, David L. Porter, Michael D. Kalos, Michael C. Milone
  • Patent number: 9464141
    Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: October 11, 2016
    Assignee: Genentech, Inc.
    Inventors: Jyoti Asundi, Suzanna Clark, Paul Polakis
  • Patent number: 9464142
    Abstract: A process is disclosed for recovering pure cellulose from a cellulose-containing sludge, the process comprising treating a sludge cellulose source under conditions permitting dissolution of non-cellulose material and suspension of the cellulose, wherein said dissolution conditions do not alter cellulose morphology.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: October 11, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Oded Shoseyov, Arnon Heyman, Shaul Lapidot, Sigal Meirovitch, Yuval Nevo, Amit Rivkin
  • Patent number: 9464143
    Abstract: The invention provides a method for producing a polymeric photoinitiator of the general formula I: Polymer-[CR2-CHR-Spacer (PI)n]m, (I) wherein m is an integer from 1-5000; n is a real number above 0 and below 5; each R group, independently, is a substituent independently selected from hydrogen, C1-C25 linear alkyl, C3-C25 branched alkyl, C3-C25 cycloalkyl, aryl, heteroaryl, —OH, —CN, halogens and amines and PI is a photoinitiator moiety. The method comprises grafting one or more photoinitiator moieties (PI), each of which comprises at least one activated alkene functional group, onto the polymer. Polymeric photoinitiators are also provided.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: October 11, 2016
    Assignee: Coloplast A/S
    Inventors: Christian B. Nielsen, Niels Joergen Madsen, Carsten Hoej
  • Patent number: 9464144
    Abstract: Disclosed herein are processes for preparing procatalyst compositions and polymers, i.e., propylene-based polymers, produced therefrom. The present procatalyst compositions improve catalyst selectivity and also increase the bulk density of the formant polymer.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: October 11, 2016
    Assignee: W. R. Grace & Co.—Conn.
    Inventors: Kelly Gonzalez, Clark C. Williams, Linfeng Chen
  • Patent number: 9464145
    Abstract: This invention relates to a novel group 4 transition metal metallocene catalyst compound that is asymmetric having two non-identical indenyl ligands with substitution at R2 having a branched C1-C20 alkyl group, R8 having a linear alkyl group and R4 and R10 having substituted phenyl groups, where at least one of R4 and R10 is a phenyl group substituted at the 3 and 5 position.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: October 11, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jian Yang, Xiongdong Lian
  • Patent number: 9464146
    Abstract: Provided are a chloroprene rubber that is less adhesive to rolls and gives a vulcanized product superior in physical properties, a production method thereof, a chloroprene rubber composition and a vulcanized product thereof. A chloroprene rubber comprising a steroid skeleton-containing compound. The chloroprene rubber may contain a steroid skeleton-containing compound in an amount of 0.01 to 1 mass %. A vulcanized product is prepared by vulcanizing a composition containing the chloroprene rubber. The chloroprene rubber can be prepared, for example, by emulsion-polymerizing chloroprene alone or chloroprene and other monomers in combination in the presence of a rosin containing a steroid skeleton-containing compound.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: October 11, 2016
    Assignee: DENKA COMPANY LIMITED
    Inventors: Sachiyo Kishi, Hiroyuki Yashima, Hidehiro Matsuda
  • Patent number: 9464147
    Abstract: The instant invention pertains to a process for preparing an ethylene homo- or copolymer in the presence of a supported chromium catalyst by slurry loop polymerization or copolymerization, whereby the resulting polymer powder has an increased powder density, in which the supported chromium catalyst has a chromium content of from 0.01 to 5 wt.-%, based on the element in the finished catalyst, and shows a particle size distribution measured according to ISO 13320-2009 comprising two main fractions one of which having a d50 of from 15 to 40 ?m and the other having a d50 of from 45 to 80 ?m said catalyst being further characterized by the fact that less than 10% wt of its catalyst particles has diameter lower than 20 ?m.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 11, 2016
    Assignee: Basell Polyolefine GmbH
    Inventors: Lars Kolling, Shahram Mihan
  • Patent number: 9464148
    Abstract: Vinyl terminated polyolefins with long chain branching produced with Salan catalysts having carbazole moieties.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 11, 2016
    Assignees: ExxonMobil Chemical Patents Inc., Ramot at Tel-Aviv University Ltd.
    Inventors: Garth R. Giesbrecht, Matthew W. Holtcamp, Moshe Kol
  • Patent number: 9464149
    Abstract: The present disclosure relates to a heat-shrinkable tube having tearability, which is made of a fluororesin, and particularly, to a heat-shrinkable tube having excellent tear straightness. Further, the present disclosure relates to a tube having high heat-shrinkage rate at low temperature. A tube including at least a fluororesin as a base resin, in which the thickness of the entanglement unit of a polymer observed on a cross-section in a longitudinal direction of the tube after being shrunk at 200° C. by 35% or more is 1 ?m to 9 ?m, has excellent tear straightness.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: October 11, 2016
    Assignee: Junkosha Inc.
    Inventors: Masahiro Suzuki, Kohei Yuri, Tomoyo Okubo
  • Patent number: 9464150
    Abstract: The present invention refers to new classes of polymerizable monomers targeting biotin, a biotin derivative, a biotin analog or a biotinylated molecule and related structures, as well as molecularly imprinted polymers obtainable by polymerization of at least one of these monomers and at least one cross-linking monomer in the presence of a suitable template molecule. The obtained polymers may be used for separation of biotin and related small molecules, together with larger biotinylated molecules of biological origin, e.g. proteins, from complex mixtures. The monomer comprises i) an isophthalic acid derivative or a pyridine-2,6-dicarboxylic acid derivative and ii) a vinyl-2-aminopyridine derivative.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: October 11, 2016
    Assignee: The University of Kent
    Inventor: Andrew Hall
  • Patent number: 9464151
    Abstract: The invention provides lactamic polymers comprising an acetoacetate moiety. The lactamic polymers may be readily functionalized and the functionalized lactamic polymers may be further derivatized to provide a wide variety of useful polymers having desirable chemical and physical properties. The lactamic polymers of the invention may be employed in a wide variety of compositions. (A); (B) wherein R1-R6, w, x, y, z, and n are described herein.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: October 11, 2016
    Assignee: ISP Investments LLC
    Inventors: David K. Hood, Karyn B. Visscher, Surya Kamln, Sounak Sarkar
  • Patent number: 9464152
    Abstract: Disclosed is a method of preparing a bio-based thermosetting foam material with improved properties, in particular improved flame retardant properties, which method includes the steps of a) producing a prepolymer by condensation of at least one phenolic compound and formaldehyde in a ratio of 1:1.0 to 3.0 using 0.15 to 5 wt % of an alkaline catalyst in the temperature range of 50 to 100° C. until the refractive index of the reaction mixture is 1.4990 to 1.5020, b) adding 2 to 40 wt % of at least one natural polyphenol at a temperature of 50 to 100° C., c) adding 2 to 10 wt % of one or more emulsifiers and mixtures thereof, d) adding 2 to 10 wt % of one or more foaming agents and mixtures thereof and e) adding 10 to 20 wt % of a curing agent and f) curing. All wt % being related to the amount of the raw materials used.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: October 11, 2016
    Assignee: HEXION INC.
    Inventors: Daniel Dahlhaus, Gunda Kuhlmann, Rosel Bölke
  • Patent number: 9464153
    Abstract: A two-component premix for preparing a heat-expandable and heat-curable epoxy-based material, comprises an isocyanate, a diol or polyol, an epoxy prepolymer, a heat-activatable hardener for epoxy prepolymers, and a heat-activatable blowing agent.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: October 11, 2016
    Assignee: Henkel AG & Co. KGaA
    Inventors: Martin Hornung, Emilie Barriau, Martin Renkel
  • Patent number: 9464154
    Abstract: A process for producing a polyurethane resin of the present invention includes a step (i) of obtaining a prepolymer by adding an alcohol (B) to isocyanate (A) such that a ratio of hydroxyl groups to isocyanato groups of the isocyanate (A) falls into a range of 10 mol % to 20 mol % and reacting the isocyanate (A) with the alcohol (B) in the presence of an acidic phosphoric acid ester (C) and a hindered amine-based compound (D), a step (ii) of obtaining a polymerizable composition in a manner in which the alcohol (B) is further added to and mixed with the prepolymer at a temperature of equal to or less than 30° C., and a step (iii) of polymerizing the prepolymer and the alcohol (B) contained in the polymerizable composition. The isocyanate (A) contains an aromatic isocyanate and the alcohol (B) has two or more hydroxyl groups and is further defined.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: October 11, 2016
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Nobuo Kawato, Tatsuya Ogawa, Toshiya Hashimoto, Mamoru Tanaka, Shigetoshi Kuma
  • Patent number: 9464155
    Abstract: An object of the present invention is to provide a moisture-curable polyurethane hot-melt resin composition with superior properties such as water resistance, fast-curing properties, and flexibility. The present invention provides a moisture-curable polyurethane hot-melt resin composition containing an isocyanate-containing urethane prepolymer (i) that is a reaction product of polyols (A) including a polyether polyol (A-1), a crystalline polyester polyol (A-2), an amorphous polyester polyol (A-3), and an acrylic polyol (A-4) with a polyisocyanate (B); and a curing catalyst (ii) represented by general formula (1) below, and also provides an adhesive and article produced using the resin composition. The adhesive produced using the moisture-curable polyurethane hot-melt resin composition according to the present invention is suitable not only for the bonding of fibers and the lamination of construction materials, but also for the lamination of optical elements.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 11, 2016
    Assignee: DIC CORPORATION
    Inventors: Yoshinori Kanagawa, Toyokuni Fujiwara, Ryou Nonaka
  • Patent number: 9464156
    Abstract: The thermoset, phase-separated polyurethane material of the flexible skin layer is produced from a reactive mixture which is made of one or more isocyanate compounds and isocyanate reactive compounds which include one or more polyol compounds, flexibilizers, chain extenders and/or crosslinkers and amine-initiators. Apart from at least one crosslinking amine-initiator, these amine-initiators further include at least one extender amine-initiator.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: October 11, 2016
    Assignee: RECTICEL AUTOMOBILSYSTEME GMBH
    Inventors: Koen Vanlandschoot, Jurgen Mispelon, Bart Haelterman, Geert Snellings
  • Patent number: 9464157
    Abstract: A polyurethane foam having excellent shape-following properties, which exhibits favorable comfort when worn on the human body, both during movement and at rest. The polyurethane foam contains a toluene diisocyanate and a polyether polyol as the main components, has a glass transition temperature, defined as the temperature corresponding with the peak value of the loss tangent, of not less than 0° C. and not more than 40° C., and in the temperature range from not less than 0° C. to not more than 40° C., the loss tangent in the frequency range from not less than 0.1 Hz to not more than 100 Hz is 0.4 or greater, and the average value of the loss tangent in the frequency range from not less than 0.1 Hz to not more than 1 Hz is not greater than the average value of the loss tangent in the frequency range from not less than 10 Hz to not more than 100 Hz.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: October 11, 2016
    Assignee: SMP Technologies Inc.
    Inventor: Shunichi Hayashi
  • Patent number: 9464158
    Abstract: The present invention relates to polyols and the preparation and use thereof.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: October 11, 2016
    Assignee: BASF SE
    Inventors: Sebastian Koch, Christian Koenig
  • Patent number: 9464159
    Abstract: The present invention relates to a polyurethane polymer prepared from a mixture comprising: (a) at least one polyol of formula (I), wherein at least three of X1, X2, X3, X4 and X5 are each independently an OH-terminated polyoxyalkylene group, and the remainder of X1, X2, X3. X4 and X5 are each independently H or absent, and Z is a central linking unit; (b) at least one di- or poly-isocyanate; and (c) optionally at least one OH-terminated chain extender. Further aspects of the invention relate to a process for preparing a polyurethane, and to a process for preparing a contact lens.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: October 11, 2016
    Assignee: OCUTEC LIMITED
    Inventors: Abdul Rashid, Roderick William Jonathan Bowers, Wade Tipton, Neil Bonnette Graham
  • Patent number: 9464160
    Abstract: The present invention comprises fluorinated ethoxylated polyurethanes of formula [Rf—(X)n—(CH2CHR1—O)m—CH2CH2—O—C(O)—NH]p-A, wherein Rf is a C1 to C6 perfluoroalkyl; X is a divalent radical; n is 0 or 1; R1 is H or C1 to C4 alkyl; m is 1 to 20; p is a positive integer of at least 2; and A is the residue of a polyisocyanate, and methods for altering surface behavior of liquids using such compounds.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: October 11, 2016
    Assignee: THE CHEMOURS COMPANY FC, LLC
    Inventors: Michael Henry Ober, Kathleen L. Kanetsky, Allison Mary Yake
  • Patent number: 9464161
    Abstract: The masterbatch-type latent curing agent for epoxy resin comprised of (A) glycidyl ether type epoxy resin, (B) a fine particle of mixture containing (B-1) 50 to 99 mass % of adduct-modified amine obtained by reacting the glycidyl ether type epoxy resin with a polyamine compound and (B-2) 50 to 1 mass % of a phenol compound, (C) an active hydrogen compound and (D) an isocyanate compound; and a one-component curable epoxy resin composition containing the masterbatch-type latent curing agent and epoxy resin.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: October 11, 2016
    Assignee: Adeka Corporation
    Inventor: Daisuke Sato
  • Patent number: 9464162
    Abstract: The present application is directed to methods for preparation of polymer particles in gel form and carbon materials made therefrom. The carbon materials comprise enhanced electrochemical properties and find utility in any number of electrical devices, for example, as electrode material in ultracapacitors or batteries. The methods herein can also be employed generally to improve emulsion and/or suspension polymerization processes by improved control of diffusion of acidic and basic species between the polymer and secondary phases.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 11, 2016
    Assignees: Georgia-Pacific Chemicals LLC, Energ2 Technologies, Inc.
    Inventors: Benjamin E. Kron, Katharine Geramita, Henry R. Costantino, Joseph Frank Ludvik, Xing Dong, Shahid P. Qureshi, Gerald A. Knazek
  • Patent number: 9464163
    Abstract: Disclosed is a novolak resin containing a repeating unit represented by the general formula (1). R1is a hydrogen atom or an alkyl group which is C1-4 straight-chain or C3-4 branched-chain, and some or all hydrogen atoms in the alkyl group may be replaced with a fluorine atom; R2 is a hydrogen atom, a phenyl group, an alkyl group which is C1-10 straight-chain or C3-10 branched-chain, or an alkyl group having a C3-10 cyclic structure, and some or all hydrogen atoms in the phenyl group and the alkyl group may be replaced with fluorine atoms; each of a and b is independently an integer of 1-3, and these are defined as 2?a+b?4; and d is an integer of 0-2. This novolak resin has high dissolution rate in the alkaline development solution in addition to the heat resisting property which is a property of phenolic resin.
    Type: Grant
    Filed: December 25, 2013
    Date of Patent: October 11, 2016
    Assignee: Central Glass Company, Limited
    Inventors: Junya Nakatsuji, Kazuhiro Yamanaka
  • Patent number: 9464164
    Abstract: Disclosed is a method for preparing polyesters, comprising reacting polyols with carboxylic acids and, optionally, a catalyst, wherein the polyols bear at least two hydroxyl groups, wherein, at least one of said hydroxyl group is bound to an aliphatic carbon atom and wherein the polyols comprise one or more compounds of the formula (I) or (II), ?where ?n is 1, 2, 3 or 4, ?m is 1, 2 or 3, ?p is 2, ?Q is sulphur or C1-C4-alkylene, and ?the radicals R1 are each, independently of any other radicals R1 present, C1-C8-alkyl or Ci-C8-alkoxy, where at least one ortho position of the two phenyl rings in the formula (II) or the phenyl ring in the formula (I) must be substituted by a secondary or tertiary radical.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: October 11, 2016
    Assignee: LANXESS Deutschland GmbH
    Inventor: Lutz Heuer
  • Patent number: 9464165
    Abstract: The present invention provides a method of preparing a polyester-based polymer and a polyester-based polymer prepared by the method. The method of preparing the polyester-based polymer includes a prepolymerization step of polymerizing a dicarboxylic acid compound (A), a diol compound (B), and an aromatic branching agent (C) at 160-220° C. to produce a prepolymer; and a condensation polymerization step of performing a condensation polymerization of the prepolymer at 200-250° C., under a vacuum pressure of 0.1 to 2 Torr.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: October 11, 2016
    Assignee: LOTTE FINE CHEMICAL CO., LTD.
    Inventors: Hee Soo Kim, Ye Jin Kim, Soo Youn Choi, Min Kyoung Kim, Ki Chull Yun
  • Patent number: 9464166
    Abstract: In a process for producing 3,4? and/or 4,4? dimethyl-substituted biphenyl compounds, a feed comprising toluene is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluenes. At least part of the hydroalkylation reaction product is dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising a mixture of dimethyl-substituted biphenyl isomers. The dehydrogenation reaction product is then separated into at least a first stream containing at least 50% of 3,4? and 4,4? dimethylbiphenyl isomers by weight of the first stream and at least one second stream comprising one or more 2,x? (where x? is 2?, 3?, or 4?) and 3,3? dimethylbiphenyl isomers.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: October 11, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jihad M. Dakka, Lorenzo C. DeCaul, Keith H. Kuechler, Neeraj Sangar, Michael Salciccioli, Alan A. Galuska, Gary D. Mohr