Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.

Abstract: The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.

Abstract: The present invention provides a biomarker for detecting and diagnosing polypoidal choroidal vasculopathy (PCV) of human eyes, including levels of hyperhomocysteinemia that are identified, wherein elevated levels of hyperhomocysteinemia are highly associated with PCV of the human eyes. In addition, the present invention further provides a method for detecting and diagnosing PCV of the human eyes.

Abstract: The invention provides novel peptide binders for streptavidin (SA), Taq polymerase and several human proteins: Prostate Specific Antigen (PSA), thrombin, Tumor Necrosis Factor Alpha (TNF?), and Urokinase-type Plasminogen Activator (uPA).

Abstract: The invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. Embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples.

Abstract: In various implementations, a noninvasive, food sensitivity test may be utilized to identify one or more food sensitivities. A fecal sample may be obtained. The food sensitivity test may be performed on the obtained fecal sample. One or more food sensitivities may be identified based on the food sensitivity test.

Abstract: This disclosure provides, in one aspect, a method for analyzing a sample from a subject for a biomarker that is indicative of the subject's immune response to ?-glucan. Generally, the method includes obtaining a biological sample from a subject, analyzing the sample for a biomarker anti-?-glucan antibody compared to a reference standard, computing a Relative Antibody Unit (RAU) value for anti-?-glucan antibody in the sample, and identifying the subject as biomarker positive if the RAU value is greater than a predetermined RAU value for the biomarker anti-?-glucan antibody.

Abstract: The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of Lyme disease. In one aspect, the present invention provides compositions and methods for treating a patient at risk for or likely to develop post-treatment Lyme disease syndrome (PTLDS). In certain embodiments, the patient is already undergoing a first course of antibiotic treatment for Lyme disease. In a specific embodiment, a method comprises the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.

Abstract: Methods, systems and kits for the early diagnosis or prediction of systemic inflammatory response syndrome (SIRS) including sepsis in asymptomatic patients, such as patients undergoing a surgical intervention, are provided. Some embodiments include a method and system for the detection or diagnosis of SIRS, or detection or diagnosis of a risk to suffer from or develop SIRS, in an asymptomatic patient comprising the steps of determining the level of IL-6 (or a variant thereof) in a sample from the patient; comparing the level of IL-6 (or a variant thereof) to a reference level; detecting or diagnosing SIRS or diagnosing a risk to suffer from or develop SIRS, wherein the sample is isolated at least 2 times at short intervals and the determining and comparing steps are both repeated for each sample. Also provided are methods, systems and kits for therapy monitoring and mortality prediction.

Abstract: The disclosure provides methods for detecting circular endothelial cells (CECs) in a non-enriched blood sample. The present disclosure is based, in part, on the unexpected discovery that CECs can be detected in non-enriched blood samples. The present disclosure is further based, in part, on the discovery that CECs can be detected in non-enriched blood samples by combining the detection of one or more immunofluorescent markers in the nucleated cells of a non-enriched blood sample with an assessment of the morphology of the nucleated cells. The present disclosure is further based, in part, on the discovery that CECs can be detected in non-enriched blood samples by comparing the immunofluorescent marker staining and morphological characteristics of CECs with the immunofluorescent marker staining and morphological characteristics of WBCs. The methods disclosed herein serve to classify human subject in myocardial infarction (MI) patients or healthy controls.

Abstract: Methods are disclosed herein for determining the likelihood that a subject will develop atherosclerotic cardiovascular disease (ASCVD) or a myocardial infarction (MI). Methods are also disclosed for determining if a pharmaceutical agent is effective for the treatment or prevention of ASCVD. In additional embodiments, methods are disclosed for determining if a pharmaceutical agent is of use in preventing an MI.

Abstract: A method of analyzing diagnostic information, the method including: measuring the concentration of all mucin-1s (total MUC1) in a blood sample originated from a subject to be diagnosed; comparing the measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of total MUC1 is greater than the threshold value.

Abstract: A method of diagnosing Alzheimer's disease in a patient comprises determining whether the phosphorylation level of an indicator protein in cells of the patient after stimulus with an activator compound is abnormally elevated as compared to a basal phosphorylation level, the indicator protein being e.g. Erk1/2 and the activator compound being e.g. bradykinin.

Abstract: Described herein are methods, systems and compositions for the diagnosis, prognosis and treatment of dementia and Alzheimers disease. Also described are methods, systems and compositions to distinguish between Alzheimers disease and Parkinsons disease. In various embodiments levels of PACAP and/or SIRT3 are analyzed for the diagnosis, prognosis and treatment of dementia and Alzheimers disease.

Abstract: A non-human transgenic animal having a polynucleotide encoding a PTN polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the PTN polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illnesses, particularly anxiety and depression, are disclosed.

Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.

Abstract: The present invention relates to clinical decision support systems. In detail, the present invention relates to a method for determining the hemostatic risk of a subject, to the use of a biomarker's threshold for determining the hemostatic risk of a subject, to a device for determining the hemostatic risk of a subject, to a computer program comprising a program code for carrying out the method for determining the hemostatic risk of a subject, and to a computer-readable non-transitory storage medium containing instructions for carrying out the method for determining the hemostatic risk of a subject.

Abstract: The present invention is directed to a novel method of determining inhibitors of proteolytically active coagulation factors, referred to herein as anticoagulants, in a sample, in particular the qualitative detection of direct thrombin and factor Xa inhibitors in a sample. The method of the present invention allows a qualitative determination of the nature anticoagulants present in a sample. This can be achieved with only one coagulation-based test. The method can be used in a test kit, including a point-of-care system.

Abstract: The invention provides compositions and methods for assessing the capacity of high density lipoprotein (HDL) to support reverse cholesterol transport in blood by measuring exchange if HDL-specific spin-labeled lipoprotein probes and electron paramagnetic spectroscopy. The invention also provides methods to identify individuals at risk for cardiovascular disease, to monitor the treatment of cardiovascular disease and in the development of therapies to treat cardiovascular disease. The invention also provides methods to identify individuals at risk for Alzheimer's disease, to monitor the treatment of Alzheimer's disease and in the development of therapies to treat Alzheimer's disease.

Abstract: A method for predicting the level of epicardial adipose tissue (EAT) in a subject comprising: (a) determining a level of one or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from the following: (i) phosphatidylcholine (PC) [16:1/16:1] (ii) diacylglycerol (DAG) [42:8] (iii) phosphatidylethanolamine-ether (PE-O) [32:5] (iv) phosphatidylcholine (PC) [18:0/22:5] (v) phosphatidylinositol (PI) [18:0/16:1] (vi) phosphatidylglycerol (PG) [20:3/20:3] (vii) phosphatidylglycerol (PG) [22:5/18:1] (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of levels of EAT fat in the subject.

Abstract: A method is described for mass spectrometric analysis, detection and quantification of catecholamines. The methods can comprise reacting the catecholamines with a 4-aminoantippyrine reagent and detecting and/or quantifying the adduct produced by the reaction. The methods can also allow for multiplexing. Compounds formed by the reactions are also provided.

Abstract: The invention relates to novel cells and cell lines, and methods for making and using them.

Abstract: An object of the present invention is to provide a biological sample measurement device having a high throughput obtained by being capable of early determining whether or not change of a washing condition is necessary. Provided is a biological sample measurement device including a measurement section that performs measurement of a biological sample, and a washing section that washes a biological sample contact portion, the biological sample contact portion contacting the biological sample during the measurement, the biological sample measurement device further including a characteristic judgment portion that judges a characteristic of the biological sample before the measurement by the measurement section is completed, and a washing control section that determines a washing method by the washing section based on the characteristic judged by the characteristic judgment section.

Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

Abstract: Certain embodiments described herein are directed to devices and system that can be used to fill a sample cell. In some examples, the system can be configured with a pressure device configured to provide a negative pressure to accelerate filling of the cell with the sample. In some embodiments, the negative pressure can be used to fill a flow cell at a selected fill rate.

Abstract: The present invention has a controller (010) to monitor the environmental temperature of automotive or industrial sensor (830) and a means of actively heating (651) or cooling (520) sensors such that the sensor (830) is not exposed to extreme cold or hot temperatures, which could negatively affect the operation of the sensor (830) either temporarily or permanently. The operator (901) is informed (356) of the future probability of measurable degraded performance of the automotive or industrial machine or thermal stress of sensors to enable the operator (901) to adjust her operation (910) of the machine and perform preventive maintenance to reduce the future probability of measurable degraded performance and thermal stress of sensor (830). There can be a plurality of sensors.

Abstract: A sensor device for contactlessly determining a revolution rate and a direction of rotation of a component that rotates during operation of the component, the component having, on at least one peripheral region, a circumferential structure of web-shaped or tooth-shaped radial protrusions and interposed grooves or tooth gaps includes: a threaded segment configured to positionally fix an arrangement of the sensor device so that the circumferential structure of the component is movable past the sensor device; a magnetic field generating device; and a magnetic field detecting device having at least three magnetic field sensors that are not arranged in alignment along a line. A distance between the magnetic field sensors that are the farthest apart from each other is less than or equal to a width of the grooves or tooth gaps of the component.

Abstract: A sensor including at least one sensor element, at least one signal processing circuit, and at least one housing inside which the sensor element and the signal processing circuit are arranged. The sensor further includes an electronic identification device.

Abstract: A multifunction probe for primary references for an aircraft, an associated measuring system, aircraft and method for obtaining physical quantities are disclosed. In one aspect, the multifunction probe includes a base designed to be fastened on the cockpit of an aircraft, a plurality of static pressure taps arranged through the base and connected to pressure measuring devices and an optical window transparent to laser radiation and positioned in the base for the passage of laser radiation through the base. The multifunction probe further includes at least one laser anemometry optical head positioned to take laser anemometry measurements through the optical window and a static temperature probe mounted on the base.

Abstract: In at least one embodiment, a handheld measurement system generates a measurement image derived from measurement data that is generated and/or received by the handheld measurement system. The handheld measurement system also generates a plurality of option images that each correspond to a particular selectable option. A display screen, which may be a touch screen, simultaneously displays the measurement image and the option images. The measurement device modifies the measurement image and/or the option images in response to received option image selections.

Abstract: Provided is a lighting fixture, which belongs to the technical field of display equipment detection and can be used for solving the problem that an existing lighting fixture is liable to damage a detection probe in a detection process. The lighting fixture includes a work load platform, a lifting unit and a lighting test unit, wherein the work load platform is used for loading a display panel to be subjected to lighting test; the lifting unit is connected with the lighting test unit and used for driving the lighting test unit to ascend and descend; and the lighting test unit is provided with a plurality of probes and is driven by the lifting unit to contact the probes with a circuit test point on the display panel, in order to carry out the lighting test on the display panel. The lighting fixture is intelligent, flexile and strong in adaptability.

Abstract: A probe includes a probe pin having a first end and a second end. The first end is connectable to a semiconductor inspection apparatus such as for electrical testing of semiconductor devices. The second end of the probe pin is for contacting an electrode or terminal of the semiconductor device being inspected. The probe pin has at least a portion between first and second ends that is coated with a magnetic substance layer, which can reduce signal noise during inspection. The probe pin is configured to apply a force for maintaining contact between the second end and the electrode when the probe is placed in contact with the first electrode. The force may be generated, for example, by a flexure design of the probe pin or by incorporation of a coil spring.

Abstract: A probe card for transmitting power signals from a tester to two devices under test (DUTs) is provided, which includes two signal pins, two power conducting circuits, and at least a matching part. The signal pins are made of conductive materials, wherein one end of the signal pin contacts one of the DUTs. The two power conducting circuits are electrically connected to the two signal pins respectively to transmit the power signals to the DUTs. One of two ends of the power conducting circuits is connected to the signal pins; the other end of the power conducting circuits is electrically connected to the tester. The matching part is electrically connected to the power conducting circuit in parallel to lower a resistance of the power conducting circuit below a predetermined value, or to lower a percentage error of resistance of the power conducting circuit below a predetermined percentage error.

Abstract: The invention relates to a probe card structure, which comprises printed circuit board structure with a first through hole, a center stiffener with a second through hole, a first probe head module with a first through hole set and a plurality of first probe pins, and a second probe head module provided with a plurality of second probe pins. The first probe head module and the second probe head module are respectively arranged on a lower surface and an upper surface of the printed circuit board structure, wherein those first probe pins are set on a periphery of an opening of the first through hole set; and a portion of the second probe head module penetrating the first through hole, the second through hole, and the first through hole set. The first and second probe head module integrated together can be utilized for 3D IC testing.

Abstract: An interposer for inspecting reliability of a semiconductor chip is disclosed. The interposer for inspection includes: at least one active pad disposed in an active region of a first surface, and including: pads through which data and a control signal for testing an inspection target chip are received (input) and sent (output) during an active mode; and pads for receiving a power-supply voltage needed to operate the inspection target chip and the interposer during the active mode; at least one passive pad disposed in a passive region of the first surface, and including: pads receiving data for testing the inspection target chip during a passive mode, and a power-supply voltage needed to operate the inspection target chip and the interposer during the passive mode; and at least one bump pad disposed over a second surface facing the first surface, and to be coupled to the inspection target chip.

Abstract: A method of increasing accuracy of optical sensors based on generating two sets of light waves having different velocities in the presence of a non-vanishing measurand field within a sensing element of the sensor is described. A defined static bias phase shift is introduced between the two sets of light waves. The sensor converts a total optical phase shift including static bias optical phase shifts and measurand-induced optical phase shifts into anti-phase optical power changes in at least two detector channels. The method includes steps of normalizing the optical power changes after their conversion into electrical detector signals in the two detector channels to reduce effects of uneven intensity or power of the light source and different loss or gain in the detector channels. Further methods, sensors and apparatus for temperature stabilizing such optical sensors and novel sensors are also presented.

Abstract: To provide a current detection circuit capable of suppressing the occurrence of a large potential difference between input terminals of a differential amplifier circuit, and preventing degradation of input transistors. A differential amplifier circuit is equipped with a clamp circuit which limits gate-source voltages of a pair of PMOS transistors each having a bulk and a source connected to each other with the sources of the pair of PMOS transistors as input terminals.

Abstract: Disclosed is a device for measuring the current and voltage of electric circuits in a building. The device has a speaker that is detachable from the housing of the device, a receiver that can use a rechargeable battery, a digital voltmeter that can accurately measure up to 220 volts, and a light fixture adapter that can detect current through a light fixture.

Abstract: A method of estimating a line voltage is provided that includes configuring a capacitive probe to a power line, injecting a perturbation voltage onto the capacitive probe, where the perturbation voltage has a different frequency than a frequency of the line voltage, measuring, using a capacitive sensor, a retrieved perturbation voltage, where the retrieved perturbation voltage is dependent on a capacitance between the capacitive probe and a ground capacitance, using an appropriately programmed computer to track real time changes in the capacitance of the capacitive probe, and estimating a line voltage.

Abstract: A method for digitizing a sensed signal in a digitally assisted current sense circuit and a digitally assisted current sense circuit that uses the disclosed method realize a simple way to sense and convert an analogue current signal into a digital signal. The method includes the steps of generating a voltage corresponding to a sensed inductor current IL; and amplifying and buffering the voltage for creating an input signal to be converted by an analogue-to-digital converter (ADC). The ADC uses an estimate of the inductor current provided by a modified digital observer circuit as a starting point for an analogue-to-digital conversion.

Abstract: A semiconductor device with the highly precise current detecting function is provided. Current detection is performed using a semiconductor device in which two semiconductor chips are mounted in one package. The first semiconductor chip is provided with an electric power supply transistor to supply power to a load via a load driving terminal, and a current detection circuit to detect a current flowing through the load driving terminal. In the inspection process of the semiconductor device, the electrical property of the current detection circuit in the first semiconductor chip is inspected, and the information on a correction equation obtained as the inspection result is written in a memory circuit of the second semiconductor chip. The second semiconductor chip corrects the detection result obtained by the current detection circuit based on the information on the correction equation written in the memory circuit concerned.

Abstract: A system and method that improves and automates the measurement of power generated by an electrosurgical generator. An active load device is coupled to the generator output and is configured to simulate the change in tissue characteristics, such as an impedance change, that occurs when such tissue undergoes electrosurgical treatment. The active load faithfully simulates the change in tissue characteristics caused by a particular mode of electrosurgical energy delivery, such as without limitation, changes caused in response to a cutting mode, a coagulation mode, a blending mode, a sealing mode, and the like. Tests are conducted in accordance with test profiles containing target impedance and power values of the test scenario. A plurality of profiles may be stored for testing under various simulated operating conditions.

Abstract: A method of monitoring power usage includes 1) accessing power usage data for power distribution unit infeeds of a plurality of power distribution units; 2) accessing stored circuit descriptions describing interconnections of the power distribution unit infeeds to a number of power feed circuits; 3) transforming the plurality of power distribution units into a power usage monitor for monitoring power usage of the power feed circuits by aggregating at least some of the power usage data based on the interconnections of the power distribution unit infeeds to the number of power feed circuits; and 4) outputting representations of the aggregated power usage data.

Abstract: A smart power plug integrated with a wireless control system for controlling and monitoring an electrical device is provided. The smart power plug has a housing for said wireless control system with first and second ends, wherein the first end includes a male power plug configured to be plugged in an electrical power outlet for electrical connection to a power source and the second end receives a power cord with a proximal end and a distal end. The distal end is configured to be connected to the electrical device.

Abstract: A storage unit stores therein first information indicating the correspondence among each acquisition time point at which a result of measuring cumulative energy consumed during the execution of a program was acquired, the cumulative energy, and the memory address of an instruction executed at the acquisition time point. The storage unit stores therein second information indicating the correspondence between each executed part of the program and a range of the memory addresses of instructions of the program. A computation unit determines time points in the execution of a predetermined executed part, on the basis of the first and second information, and calculates cumulative energy for each of the time points with linear interpolation.

Abstract: A spectrum analyzer for a signal IRF comprising a plurality of frequencies fi comprises N entities each made up of a structure formed by a stack of magnetic and non-magnetic layers having in at least one of the magnetic layers a magnetic configuration in the shape of a vortex, the excitation modes of the magnetic configuration being suitable for detecting the frequencies contained in an incident signal in real time, each entity having a first lower electrode and a second upper electrode, a voltage-measuring device suitable for measuring an electric voltage showing the presence of a frequency fk in the analyzed signal IRF, the device being connected to the lower electrode and to the upper electrode, a measurement-processing device suitable for determining the value of the frequencies fk in the signal IRF, and a line carrying the signal to be analyzed to each of the entities.

Abstract: Disclosed are an apparatus and a method for non-contact sample analysis using terahertz waves. The apparatus includes an emission unit radiating terahertz waves onto a sample provided with a conductive material layer, and a receiving unit receiving terahertz waves reflected from the sample or terahertz waves passing through the sample.

Abstract: Method and device for impedance analyzer with binary excitation with improved accuracy, where the non-idealities of the sampling and preprocessing of the response signal (including aliasing effects) are taken into account by using of the overall system model with equivalent circuit diagrams of the analyzed object and the model of the preliminary analysis of the response signal. The analysis result is the equivalent circuit diagram with component values with the best match of the overall model analysis and of the preliminary analyze of the response signal. Further, the analysis result can be the impedance frequency characteristic or the classifier of the analyzed object. It could be reasonable to use the pre-calculated function (e.g. in the form of the look-up-table) for matching the results of the over-all model against the preliminary analyzed results of the response signal.

Abstract: In accordance with an embodiment, a method of performing a measurement with a capacitive sensor includes generating a periodic excitation signal that includes a series of pulses and smoothing edge transitions of the series of pulses to form a shaped periodic excitation signal that includes a flat region between the smoothed edge transitions. The method further includes providing the shaped periodic excitation signal to a first port of the capacitive sensor and measuring a signal provided by a second port of the capacitive sensor.

Abstract: A composite substrate sensor device comprises: a first substrate sensing chip having an upper surface, a lower surface, side surfaces and scanning and receiving circuit cells; a second substrate connected to the first substrate sensing chip; an insulating layer set comprising insulating layers and disposed on upper surfaces of the second substrate and the first substrate sensing chip on a virtual common plane; scanning and receiving electrode cells disposed on an upper surface of the insulating layer set on a physical common plane substantially parallel to the virtual common plane; and scanning and receiving wires formed on the insulating layer set and electrically connecting the scanning and receiving electrode cells to the scanning and receiving circuit cells, respectively, so that the receiving circuit cells sense an electric field variation of an object through the receiving electrode cells and receiving wires. A method of manufacturing the sensor device is also provided.