Abstract: A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.

Abstract: Some embodiments provided herein relate to bioluminescent packaging, methods of making, and methods of sensing the state of a material. In some embodiments, light emitted by a bioluminescent organism can be used to sense the state of a material.

Abstract: The present invention aims to solve problems in the analysis of amplified nucleic acids, i.e., cost, workability, and contamination and pollution of samples. In the present invention, a sample containing a nucleic acid and a reagent for detecting the nucleic acid are mixed in a closed system. In this regard, the nucleic acid is amplified in the same closed system, and then mixed with the detecting reagent without opening the system. In order to carry out this method, for example, a device that includes the detecting reagent shielded by a coating material or the like is used.

Abstract: A control system and method are provided for use in managing optical measurements on target structures. The control system comprises: data input utility for receiving input data indicative of a size of a target structure to be measured and input data indicative of illumination and collection channels of an optical measurement system; data processing utility for analyzing the input data, and an interplay of Point Spread Functions (PSFs) of the illumination and collection channels, and determining data indicative of optimal tailoring of apertures to be used in the optical measurement system for optimizing ensquared energy for measurements on the given target structure, the optimal tailoring comprising at least one of the following: an optimal ratio between numerical apertures of the illumination and collection channels; and an optimal orientation offset of physical apertures in the illumination and collection channels.

Abstract: Metrology targets, design files, and design and production methods thereof are provided. The metrology targets are hybrid in that they comprise at least one imaging target structure configured to be measurable by imaging and at least one scatterometry target structure configured to be measurable by scatterometry. Thus, the hybrid targets may be measured by imaging and scatterometry simultaneously or alternatingly and/or the measurement techniques may be optimized with respect to wafer regions and other spatial parameters, as well as with respect to temporal process parameters. The hybrid targets may be used to monitor process parameters, for example via comparative overlay measurements and/or high resolution measurements.

Abstract: Featured are a device (20) and method for the detection of counterfeit pharmaceuticals and/or packaging therefore. Counterfeit pharmaceuticals are detected by visual inspection upon exposing a suspected counterfeit pharmaceutical to one or more light sources having different wavelengths, and observing the differences in color and/or brightness between the suspected counterfeit and a genuine pharmaceutical/packaging. In further embodiments, a image acquisition device acquires an image showing color and/or other visual effect(s) brightness of the suspect counterfeit and this image is compared to an image of a authentic pharmaceutical/packaging.

Abstract: Inventive concepts provide a method of inspecting a semiconductor device including obtaining inspection image data of an inspection pattern of an inspection layer on a substrate. The method may include extracting inspection contour data including an inspection pattern contour from the inspection image data, and merging the inspection contour data with comparison contour data of a comparison layer to obtain merged data. The comparison layer may overlap the inspection layer. The method may also include determining a horizontal distance between the inspection pattern contour and a comparison pattern contour of the comparison contour data based on the merged data.

Abstract: The invention provides a method and apparatus for a commercially viable EUV light source for EUV metrology and actinic inspection of EUV lithography masks. The invention is carried out using a laser target in the form of a continuous jet of liquid Lithium, circulated in a closed loop system by means of a high temperature pump. The collector mirror is placed outside the vacuum chamber in an environment filled with an inert gas and EUV output to a collector mirror is provided through the spectral purity filter, configured as an EUV exit window for the vacuum chamber. In the vacuum chamber, the input window for the laser beam is coated with a screening optical element. Evaporative cleaning of the EUV spectral purity filter and the screening optical element is provided. The protective shield with a temperature higher than 180° C. may be adjusted around the target jet.

Abstract: A method and system are provided for inspecting a plurality of target features arrayed in spaced arrangement on a surface of a target object, such as but not limited to inspection of the location of cooling air holes in the surface of a turbine blade or vane.

Abstract: A device for measuring at least one of dielectric and magnetic properties of a sample by means of a microwave transmission measurement includes a transmitting antenna and a receiving antenna defining a transmission measuring section in which the sample to be measured is located, and transmitting and receiving modules. The transmitting and receiving modules include one or more transmission-side and receiving side synthesizers, a clock, one or more transmission side or receiving side mixers to generate intermediate-frequency signals based on high-frequency signals received from the synthesizers, and at least one evaluation unit to perform an evaluation based on the intermediate-frequency signals.

Abstract: Initial values A^1P^1M^1 . . . A^nP^nM^n of parameters representing a geometric relationship between an X-ray tube, a stage and a flat panel X-ray detector are estimated, a least squares solution (p^W)i of characteristic point three-dimensional coordinates is estimated, and only limited parameters are updated until reprojection square errors converge. Thus, based on known radiographic conditions, initial values of the parameters are estimated, and a nonlinear optimization operation is carried out on only the parameters considered, in view of mechanisms and drive characteristics of the apparatus, to have large errors between the initial values of the parameters and the parameters at a time when radiography is actually carried out. As a result, the calculation can be speeded up, while securing the convergence accuracy of the nonlinear optimization operation, by using the radiographic conditions, i.e. information on tomography.

Abstract: The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device.

Abstract: The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium.

Abstract: A spectroscopic sample analysis apparatus includes an actively controlled heat exchanger in serial fluid communication with a spectroscopic analyzer, and a controller communicably coupled to the heat exchanger. The heat exchanger is disposed downstream of a fluid handler in the form of a stream selection unit/stream switching unit (SSU), a solvent/standard recirculation unit (SRU), and/or an auto-sampling unit (ASU). The SSU selectively couples individual stream inputs to an output port. The SRU includes a solvent/standard reservoir, and selectively couples output ports to the heat exchanger, and returns the solvent/standard sample to the reservoirs. The ASU includes a sample reservoir having a sample transfer pathway with a plurality of orifices disposed at spaced locations along a length thereof. The controller selectively actuates the fluid handler, enabling sample to flow there through to the heat exchanger, and actuates the heat exchanger to maintain the sample at a predetermined temperature.

Abstract: Monitoring cell (100) for performing an NMR measurement of a reaction fluid. The monitoring cell (100) has a hollow NMR sample probe (110) for receiving the reaction fluid. Inlet and outlet transport capillaries (112, 123) transport the reaction fluid to and from the sample probe (110). A feed line (306) and return line transport a temperature control fluid to and from the monitoring cell (100). An adapter head (108) couples the transport capillaries (112, 123) to the sample probe (110) and removably connects the sample probe (110) to an adapter section (106). The transport capillaries (112, 123) are positioned within the feed line (306) in parallel to one another. The feed and the return lines (306, 358) are attached to the adapter section (106) such that a reversal of the temperature control fluid stream occurs in the adapter section (106).

Abstract: A biosensor system can comprise a sensor chip and a measurement device. The sensor chip comprises a capillary and electrodes disposed within the capillary. The height of the capillary is set to be less than the maximum value of the sum of the diffusion distance of an electron-transfer mediator and the diffusion distance of an analyte at the upper limit of the measurement guaranteed temperature of the biosensor system. The measurement device applies an open circuit voltage, a voltage that is lower than during concentration measurement, or the like to the electrodes of the sensor chip.

Abstract: Disclosed is a method and apparatus for reducing electromagnetic noise pick up in a Liquid Metal Cleanliness Analyzer (LiMCA), used to detect and measure particles in molten metal. A first electrode inserted in the molten metal is electrically insulated from second and third electrodes, also inserted in the molten metal. Molten metal and particles pass between the first electrode and the second and third electrodes through a passage in the electrical insulation. The second and third electrodes have a configuration with respect to the first electrode sufficient to establish symmetrical current loops between the first electrode and the second and third electrodes when a current is supplied to the second and third electrodes. The current is supplied from an ultra-capacitor. Electromagnetic noise in the symmetrical current loops is detected and is added in opposition to reduce the amplitude of the electromagnetic noise.

Abstract: The presently disclosed subject matter relates to sensors for measuring an amount of a gaseous species in a sample. The sensors comprise a gas permeable polysiloxane network membrane, comprising both alkyl and fluorinated alkyl groups. In some embodiments, the polysiloxane network can be formed from the co-condensation of a mixture of an alkylalkoxysilane and a fluorosilane. The presently disclosed subject matter also relates to methods of making the sensors, methods of selectively measuring an amount of a gaseous species, such as nitric oxide, in a sample, and to compositions comprising the polysiloxane networks.

Abstract: A manufacturing method of an electrochemical sensor comprises forming a graphene layer on a donor substrate, laminating a film of dry photoresist on the graphene layer, removing the donor substrate to obtain an intermediate structure comprising the film of dry photoresist and the graphene layer, and laminating the intermediate structure onto a final substrate with the graphene layer in electrical contact with first and second electrodes positioned on the final substrate. The film of dry photoresist is then patterned to form a microfluidic structure on the graphene layer and an additional dry photoresist layer is laminated over the structure. In one type of sensor manufactured by this process, the graphene layer acts as a channel region of a field-effect transistor, whose conductive properties vary according to characteristics of an analyte introduced into the microfluidic structure.

Abstract: A method of forming a sensor component includes forming a first layer over a sensor pad of a sensor of a sensor array. The first layer includes a first inorganic material. The method further includes forming a second layer over the first layer. The second layer includes a polymeric material. The method also includes forming a third layer over the second layer, the third layer comprising a second inorganic material; patterning the third layer; and etching the second layer to define a well over the sensor pad of the sensor array.

Abstract: An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.

Abstract: The present invention comprises methods and systems that use acoustic radiation pressure.

Abstract: A method of detecting a target analyte in a sample, including executing electrowetting-mediated droplet operations and thereby: combining one or more immunoassay reagent droplets comprising magnetically-responsive beads having affinity for the target analyte with one or more sample droplets potentially comprising the target analyte to yield a first combined droplet; beginning with the combined droplet, effecting a droplet-based washing protocol to wash the magnetically-responsive beads to yield a first washed droplet comprising the washed magnetically responsive beads; and combining the droplet comprising the washed magnetically responsive beads with a droplet comprising a reporter molecule having affinity for target analyte captured on the magnetically-responsive beads to yield a second combined droplet; beginning with the second combined droplet, effecting a droplet-based washing protocol to wash the magnetically-responsive beads to yield a second washed droplet comprising the washed magnetically responsive

Abstract: The apparatus employs the remote field eddy-current (RFEC) inspection technique to electromagnetically measure physical parameters of a metallic pipe. RFEC devices inserted into and displaced along a cylindrical pipes may be used to measure the ratio of pipe thickness to electromagnetic skin-depth and thus allow for the non-invasive detection of flaws or metal loss. Typically these RFEC thickness measurements exhibit a so-called double-indication of flaws, an undesired artifact due to a double-peaked geometrical sensitivity function of the device. The method describes a means by which this double indication artifact may be removed by an appropriate processing of RFEC measurements performed by an apparatus specifically designed for this purpose. The invention is particularly well designed for applications in the oilfield industry.

Abstract: Disclosed is a clamp-on-type ultrasonic concentration metering system and method. The clamp-on-type ultrasonic concentration metering system includes an ultrasonic sensor portion and a concentration meter. The ultrasonic sensor portion is attached to an outer wall of a pipe through which a fluid to be measured flows and that transmits and receives an ultrasonic signal through a wall of the pipe. The concentration meter measures a concentration of a substance according an intensity of the ultrasonic signal that is received after passing through the wall of the pipe, the fluid to be measured, and the wall of the pipe by means of the ultrasonic sensor portion.

Abstract: A calibration method for calibrating a phased array probe that is used for testing girth welds for defects. The method utilizes a calibration device on which is defined a series of reflectors that correspond to a series of target zones. The phased array probe is placed via a wedge relative to the calibration device and the phased array probe is configured with an initial set of acoustic parameters which define at least a transmitting aperture, a receiving aperture and a beam steering angle. Using a Full Matrix Capture (FMC) acquisition process and a ray-tracing module, the values of the initial set of acoustic parameters are optimized to evolve a final set of acoustic parameters which the phased array probe utilizes for testing actual devices for weld defects.

Abstract: An apparatus for detecting fatigue induced failure of an assembly having a single flexible element or a series of flexible elements stacked in juxtaposed engagement, for transmitting power from one component to another, the assembly having a cyclic operating speed frequency that includes at least one sensor mounted in proximity to said assembly, the sensor providing an analog signal corresponding to an airborne acoustic signal emitted by the assembly, means for amplifying the analog signal, filter means to reduce background noise from the analog signal, an analog to digital converter for converting the analog signals to a digital signal, means for sampling the digital signals in respect of the operating speed frequency of the assembly and means for analyzing the digital signals and providing an output upon the occurrence of one or more digital signal spikes in an operating cycle.

Abstract: In order to reduce the variation of transmitting and receiving sensitivity among a plurality of CMUT cells, an ultrasound diagnostic device comprises: a plurality of CMUT cells each having a vibrating membrane that vibrates when ultrasound is transmitted to or received from a subject; an upper electrode and a lower electrode disposed facing each other on mutually opposite sides of each of the CMUT cells to apply a bias voltage to each of the CMUT cells by a bias power supply; and transmitting and receiving correction units for each correcting the voltage supplied from the bias power supply by using a function using at least one parameter of the thickness and resonance frequency of the vibrating membrane of each of the CMUT cells.

Abstract: A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.

Abstract: A gas sensor element comprises an elongated plate-like element including, at a forward end portion, a detecting section comprising a solid electrolyte body having an outer surface and a back surface, a detection electrode on the outer surface and a reference electrode on the back surface, and a porous layer covering the detection electrode. The coating layer includes a first protection layer entirely covering the detecting section, and a second protection layer circumferentially covering the first protection layer and extending at least from a forward end of the first protection layer to a position located rearward of the porous layer. The thickness of the first protection layer on the porous layer is larger than that of the first protection layer rearward of the porous layer. The thickness of the second protection layer rearward of the porous layer is larger than that of the second protection layer above the porous layer.

Abstract: A shield has a detector installing hole having a central axis orthogonal to a central axis of a detection tube. A radiation sensor of a columnar scintillation detector to which a low concentration side measurement range within all required measurement ranges is allocated is arranged inside the detector installing hole. An ionization chamber to which a high concentration side measurement range is allocated is arranged side by side in parallel with the detection tube. The measurement range of the columnar scintillation detector and the measurement range of the ionization chamber are adjusted so as to be overlapped with each other.

Abstract: A system and method for obtaining multispectral images of fresh meat at predetermined wavelength bands at a first time, subjecting the images to analysis in an image analysis system comprising a computer programmed to perform such analysis, and outputting a forecast of meat tenderness at a later point in time. Predetermined key wavelength bands are precorrelated with a high degree of prediction of meat tenderness and/or other properties of meat and are used in the multispectral system and method. A system and method for determining the key wavelengths is also disclosed. The multispectral imaging system and method is suitable for use in an industrial setting, such as a meat processing plant. The system and method is useful in a method for determining quality and yield grades at or near the time of imaging in lieu of visual inspection with the unaided human eye, increasing efficiency and objectivity.

Abstract: Apparatuses for analyzing total carbon and chemical oxygen demand in a sample are disclosed. Also disclosed is a method for analyzing carbon and chemical oxygen demand.

Abstract: Products and processes are provided herewith for analyzing octane content in a fuel sample that include the step or steps of receiving an octane measurement of a fuel sample from a octane analyzer, rounding the octane measurement to a nearest recognized octane rating, comparing the rounded octane measurement with a listed octane rating for the fuel sample, and communicating results of the comparison to a user of the octane analyzer. The octane analyzer may be incorporated into a fuel pump or a vehicle. The results of the comparison may also be used to adjust the vehicle operating parameters to account for the actual octane rating of the fuel dispensed into the vehicle.

Abstract: The present invention provides methods for: diagnosing of, devising and monitoring a treatment plan for, and monitoring the status of a kidney disorder characterized by an abnormal loss of renal function, renal failure, reduced glomerular filtration rate or glomerulonephritis, in a canine, wherein the kidney disorder is detectable by utilizing at least one relevant biomarker isolated and measured from a biological test sample taken from such canine. The invention additionally relates to compositions, reagents and kits for carrying out the specified methods.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Abstract: The invention relates to the fields of screening assays, compounds, and methods for altering gene expression and protein levels. In particular, the invention includes assays to screen for agents capable of modulating gene expression in a UTR-dependent manner and agents capable of modulating gene expression.

Abstract: A computer system is provided for determining the relative effectiveness of anti-cancer drugs. The interface has selectable options, including an option to manage drug testing parameters, and enables user selection of desired drug testing parameters in relation to a virtual well plate associated with a physical well plate of a spectrophotometer. The computer system causes the spectrophotometer to start a drug test, wherein the physical well plate includes at least one test well containing viable cancer cells; and at least one drug candidate in a predetermined concentration; and at least one control well containing the viable cancer cells alone. The system records the optical density of the well at a predetermined wavelength at selected time intervals for a selected duration of time, and stores the optical density and time measurements in the database.

Abstract: A novel convenient method for evaluating the function of a phagocyte is provided. The method assays sCD14-ST, which is a humoral factor specifically produced in phagocytosis by the phagocyte and which is stable enough for use in an assay. Also provided is a method for detecting diseases associated with the phagocytosis by the phagocyte.

Abstract: The disclosure relates to methods for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid sample. The disclosure further relates to kits for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid, the procedure comprising the step of release of the vitamin D from the serum binding protein (DBP), capturing of the released analyte by a specific antibody and competitive assay of the captured vitamin D against a conjugate between the vitamin D and a tracer. The observed signal is inversely proportional to vitamin D concentration.

Abstract: The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid substrate comprising a bound immobilization agent and an capture agent and a detectable agent, which can bind to the analyte. The capture agent comprises, at a plurality of sites, a ligand for the immobilization agent. A complex between the analyte, the capture agent and a detectable agent is formed and immobilized on the solid substrate by binding between the immobilization agent and the ligand. In some embodiments, the ligand and the immobilization agent are a binding pair comprising a peptide tag and an anti-peptide tag antibody.

Abstract: A test device for use with a liquid solution includes a housing that houses a plurality of sorbent strips. At least one strip has a location for receiving the solution. The housing defines at least an opening in said housing wherein said opening is aligned with the location for receiving the solution. The device includes a sealed reservoir filled with the liquid solution, the sealed reservoir being disposed in alignment with the opening and coupled to the housing. The device includes an opener coupled to the housing. The opener is arranged to rotate from a first position, in which the opener is not in contact with the sealed reservoir, to a second position, in which the opener causes the sealed reservoir to effect a release of the solution from the reservoir and into the opening and onto the sorbent strip housed within the housing.

Abstract: The present invention relates to a method for screening a sol composition for sol-gel biochips, which is used to immobilize a probe on a surface-untreated substrate, also relates to a sol composition screened by said method and a sol-gel biochip comprising said sol composition immobilized thereon. The sol composition screened by the disclosed method can be mixed with a probe, and the sol mixture can be integrated on 96-well plates, which are widely used in existing bioassays, without surface treatment. Also, the biochip can provide a sensitive and specific good analysis results because this immobilization methods of probe maintain the nature of probes without modification.

Abstract: An in-vitro process for the quick determination of the infection status of a Mycobacterium tuberculosis infection from whole blood in terms of active or latent tuberculosis, comprising the steps of: stimulating an antigen-specific T cell that is present in a first sample of whole blood with purified protein derivative (PPD) in the presence of antibodies against CD28, or CD28 and CD49d; processing of PPD by antigen-presenting cells (APC) by incubating for 1.5 h to 2.5 h, especially for 2 h, at 35° C. to 39° C., especially at 37° C., optionally with adding CO2; then adding a secretion inhibitor; effecting an intensive mixing; and another incubation for a period of at least 2.5 h at a temperature of from 35° C. to 39° C.

Abstract: The present invention relates to a method for polypeptide transfer into cells. The present invention further relates to the detection of polypeptide-specific immune cells and the priming, expansion and reactivation of polypeptide-specific T cells. Moreover the present invention relates to polypeptides of the methods of the present invention in combination with urea and their use for research, diagnosis or treatment and prevention of diseases in animals and humans.

Abstract: A test strip detection system, comprising a test strip card (1) and a detection device (2); the test strip card (1) comprises a card box (16), a built-in test strip (15) and an electronic label (20) matched with the built-in test strip (15); the electronic label (20) stores parameters such as the standard working curve of an object to be detected and the like; the detection device (2) comprises an optical system (3), a photoelectric detector (4), an analog/digital converter (5), a data processing device (6), an electronic label read-write module (10) with an aerial (11), a voice module (34), a cell box (7) and an output display device (8). The system further comprises a wireless communication module (12) and a wireless network system (13) connected with the wireless communication module (12) and comprising a remote server (14).

Abstract: Methods for detecting acute kidney injury in an individual comprise (a) contacting a body fluid sample from the individual with an assay device including neutrophil gelatinase-associated lipocalin (NGAL) antibody and a detectable label, to allow complexing of NGAL protein in the sample with NGAL antibody, and determining an amount of complex formed between NGAL protein from the sample and NGAL antibody in the assay device using the detectable label, wherein NGAL antibody in the device has binding capacity with more than two NGAL protein epitopes, and wherein the amount of the formed complex represents a level of acute kidney injury. Methods for determining an origin of NGAL protein in a sample from an individual include the step of determining relative amounts of monomeric, dimeric and heterodimeric forms of NGAL protein in the sample and allow improved diagnosis and therefore better targeted treatment.

Abstract: The present invention is directed towards methods for measuring and assaying PAS Kinase activity. The methods are useful, for example, for detecting PASK activity in a cell, and for screening for small molecule regulators of PAS kinase activity, as well as characterizing endogenous factors and stimuli that modulate PAS kinase activity, and identifying and optimizing the activity of potential PAS kinase inhibitors.

Abstract: The invention provides assays, methods, systems, compositions, and kits for diagnosing and treating cancer.

Abstract: Disclosed are conjugates that can bind to one or more site on cancer cell surface, for example, surface proteins, compound specific receptors and carbohydrates that comprise the surface of specific cell types. The disclosed conjugates can thereby serve as indicators identifying the presence of cancerous tissue.