Patents Issued in December 1, 2016
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Publication number: 20160349234Abstract: A platelet impedance measurement system including an electrode assembly allows for measurement of platelet function in blood. The assembly includes a substrate that acts as a substantially rigid base and includes an electrode. A portion of the electrode is exposed such that, when the electrode is placed in blood, the exposed portion is in contact with the blood for measuring impedance changes as platelets adhere to the electrode. Wires of the electrode can be attached to each end of the substrate and can run within a groove along a portion of the substrate. The substrate includes an open area where the wires in the groove exit and re-enter the substrate at the end of the substrate, allowing the wires to be exposed to the blood. The open area includes a brace, ensuring that the exposed wires are held in the appropriate placement relative to each other and to the cuvette.Type: ApplicationFiled: September 24, 2015Publication date: December 1, 2016Inventors: Robert Hillman, Michael M. Gorin, Cory Lee McCluskey
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Publication number: 20160349235Abstract: A system and method for analyzing protein migration in serum protein electrophoresis is disclosed. A serum sample from a subject is collected and serum protein electrophoresis is performed to separate the plurality of proteins in the serum sample. A result of the serum protein electrophoresis is generated and displays a series of peaks. The peak distance between the albumin peak and another normal SPEP protein peak (alpha-1, alpha-2, beta-1, beta-2 or gamma) is measured and compared against the peak distance between the albumin peak and another peak of interest. By dividing the peak distances, a relative migration ratio is calculated. This migration ratio can be used to quantitatively describe migration of peaks in serum protein electrophoresis and to normalize variation in gel migrations between different serum protein electrophoresis measurements, which can be utilized to aid in the interpretation of the serum protein electrophoresis.Type: ApplicationFiled: May 26, 2016Publication date: December 1, 2016Inventor: Joshua A. Bornhorst
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Publication number: 20160349236Abstract: Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds.Type: ApplicationFiled: August 11, 2016Publication date: December 1, 2016Inventors: Stanley L. Hazen, Zeneng Wang, Bruce S. Levison
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Publication number: 20160349237Abstract: A device and method for assigning a blood plasma sample to a class from a predetermined set of classes are presented. The set of classes comprises a good class, a lipemic class, a hemolytic class and an icteric class. For assignment to one of the classes, the blood plasma sample is exposed to light and measurement values dependent on transmitted or scattered light power are evaluated in order to carry out an assignment.Type: ApplicationFiled: August 11, 2016Publication date: December 1, 2016Inventors: Darko Klinec, Michael Koehler
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Publication number: 20160349238Abstract: A method for measuring human exhaled air by means of gas chromatography and ion mobility spectrometry, wherein an exhaled air sample enters a sample loop via a sample inlet and a multi-port valve and is subsequently conveyed by means of a carrier gas from the sample loop, via the multi-port valve through a gas chromatographic column, into an ion mobility spectrometer, and measured, which method is to provide reliable and accurate measurement results.Type: ApplicationFiled: November 21, 2014Publication date: December 1, 2016Applicant: IMSPEX DIAGNOSTICS LTDInventors: Stefanie SIELEMANN, Thomas WORTELMANN
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Publication number: 20160349239Abstract: In a method for detecting and controlling of driving whilst under the influence of alcohol, breath alcohol concentrations of a user are received from an alcohol sensor at predetermined time periods. The breath alcohol concentrations are analyzed to construct a regression curve, and a target time when the user will have become sober can be predicted according to the regression curve. When a dangerous work is done before the target time, an audible warning can be outputted through an output device.Type: ApplicationFiled: July 8, 2015Publication date: December 1, 2016Inventor: CHENG-CHING CHIEN
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Publication number: 20160349240Abstract: A technique which makes it possible to more precisely evaluate how a chemical substance is efficacious upon a cell aggregate is suggested. An efficacy evaluation method for evaluating a drug efficacy of a chemical substance upon a cell aggregate inside a liquid which is contained in a container comprises: acquiring tomographic images of the cell aggregate which are imaged along cross sections which approximately match with a vertical plane (Step S102); calculating a feature amount of the cell aggregate based on the tomographic images (Step S105); and determining the drug efficacy of the chemical substance based on the calculation result of the feature amount.Type: ApplicationFiled: November 18, 2014Publication date: December 1, 2016Applicant: SCREEN HOLDINGS CO., LTD.Inventors: Hiroki FUJIMOTO, Masayoshi KOBAYASHI, Ryuzo SASAKI
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Publication number: 20160349241Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods analyzing cells, methods of making arrays, and the like.Type: ApplicationFiled: May 22, 2014Publication date: December 1, 2016Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
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Publication number: 20160349242Abstract: The invention provides platform technologies for spontaneously occurring diseases that can be used for translational medicine. Non-human companion animals, such as dogs, spontaneously develop diseases that mirror human diseases. Using companion animals that develop spontaneously occurring diseases can benefit the time and cost for translational medicine by allowing for testing of one or more parameters that would otherwise not be permitted under FDA regulations. Furthermore, companion animals are also helped by potential discoveries that could cure or treat their spontaneously occurring diseases.Type: ApplicationFiled: January 28, 2016Publication date: December 1, 2016Inventor: MATTHEW FRANK
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Publication number: 20160349243Abstract: The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a DNA sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the DNA sequence-specific transactivator. The target promoter sequence can be recognized by a transcriptional regulatory polypeptide capable of modulating specific signaling pathways that enhance plant performance or yield.Type: ApplicationFiled: April 13, 2016Publication date: December 1, 2016Applicant: Koch Biological Solutions, LLCInventors: Joshua I. Armstrong, Hans E. Holtan, Masa-aki Ohto, Adina M. Bailey, Robert A. Creelman
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Publication number: 20160349244Abstract: This invention is provided for multi-unit plate with at least one unit comprised of a membrane, preferably nitrocellulose or PVDF membrane, associated with a supporting structure to allow for electroblotting of the membrane. This multi-unit plate is suited for high throughput immunoblot analysis including Zestern analysis.Type: ApplicationFiled: May 26, 2015Publication date: December 1, 2016Applicant: Zestern Biotechnique LLCInventor: Jiandi Zhang
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Publication number: 20160349245Abstract: A fluorescence molecular probe having a hydrophilic polypeptide backbone conjugated with a hydrophobic alkyl chain and a function group with aggregation induced emission is disclosed. The hydrophilic peptide sequence renders DNA binding capacity and the hydrophobic alkyl chain provides capacity for embedding within cell membrane. The aggregation induced emission renders real time tracking for live cell function studies. The synthesis of the probe is simple and easy for purification.Type: ApplicationFiled: May 26, 2015Publication date: December 1, 2016Inventors: Chunqiu Zhang, Guozhang Zou
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Publication number: 20160349246Abstract: To provide a method for separating a vesicle having a lipid bilayer membrane, which has excellent efficiency of removing impurities and is unsuch asly to cause disruption of the vesicle having a lipid bilayer membrane. A method for separating the vesicle having the lipid bilayer membrane including: a complex forming step for forming a complex of the vesicle and the solid phase carrier by bringing a biological sample including a vesicle having a lipid bilayer membrane into contact with a solid phase carrier to which a ligand for recognizing a surface antigen present on a surface of the vesicle and is bound, a washing step for washing the complex, wherein at least any of the complex forming step and the washing step is performed in the presence of a nonionic surfactant.Type: ApplicationFiled: November 6, 2014Publication date: December 1, 2016Applicants: JSR LIFE CORPORATION, JSR LIFE SCIENCES CORPORATIONInventors: Hiroya FUJII, Motoaki MIZUUCHI, Tetsuji YAMAGUCHI, Hiroki ABE
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Publication number: 20160349247Abstract: Method for determining characteristic parameters for the interaction between one or more species immobilized to a solid support surface and binding partners to the multispecific species in solution, using at least one solid support with only one target immobilized and at least one solid support with at least two targets immobilized. In the method, the binding curves, both for single-target and multi-target binding are represented as multidimensional fingerprints.Type: ApplicationFiled: February 2, 2015Publication date: December 1, 2016Inventor: Karl ANDERSSON
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Publication number: 20160349248Abstract: The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen.Type: ApplicationFiled: August 11, 2016Publication date: December 1, 2016Inventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Publication number: 20160349249Abstract: This invention relates to a method of manufacturing a lateral-flow immunochromatographic chip using the protein enzyme-simulating catalytic activity of inorganic nanoparticles and, more particularly, to a method of fixing an antibody, which is capable of detecting an analyte, to nanoparticles of iron oxide (Fe3O4) and platinum (Pt), and amplifying a chromogenic signal using an enzyme-substrate reaction of the resulting nanoparticles, and a lateral-flow immunochromatographic chip manufactured using the same. The lateral-flow immunochromatographic chip is used to manufacture a bio-chip for detecting component materials with high sensitivity. The lateral-flow immunochromatographic chip according to this invention includes a conjugation unit that includes enzyme-mimic inorganic nanoparticles labeled with a detection antibody.Type: ApplicationFiled: January 15, 2015Publication date: December 1, 2016Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: JUNSANG DOH, JINWOO LEE, MIJU KIM, MINSU KIM
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Publication number: 20160349250Abstract: The present invention relates to a use of a protein nanoparticle-based hydrogel, and more particularly, to a use of a protein nanoparticle-based hydrogel capable of highly sensitive and simultaneous multi-detection of disease markers by using a hydrogel within which protein nanoparticles presenting multiple copies of disease marker detection probes are immobilized.Type: ApplicationFiled: May 11, 2016Publication date: December 1, 2016Inventors: Jeewon LEE, Eun Jung LEE, Jong Hwan LEE
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Publication number: 20160349251Abstract: The invention provides immunochromatographic test strips and methods for detecting and quantifying S-Adenosylmethionine (SAM), S-Adenosylhomocysteine (SAH) and Homocysteine (HCy) in a sample, comprising: (a) making fluorophore conjugated antibodies; (b) immobilizing SAM, SAH and HCy on a solid support; (c) providing a sample, combining said sample with a conjugate selected from the group consisting of lanthanide chelate conjugates and quantum dot conjugates (QD) with anti-SAM, anti-SAH or anti-HCy, wherein said combining is performed under conditions that allow formation of a competitive complex comprising said conjugate, said SAM, SAH or HCy on the solid support and SAM, SAH or HCy in a sample when present; and (d) detecting the presence of the complex, if present, by monitoring a spectral emission mediated by the fluorescent conjugates in the complex, wherein the emission indicates the presence and quantity of SAM, SAH or HCy in the sample.Type: ApplicationFiled: May 25, 2016Publication date: December 1, 2016Inventors: Xiujuan Hao, Junhua Wu, Chaoyi Deng
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Publication number: 20160349252Abstract: A system for determining a level of cotinine in a sample includes a test strip system configured to receive a sample, the test strip system including a first lateral flow test strip and a second lateral flow test strip, the first and second lateral flow test strips each having an overlapping but non-identical range for cotinine. The system further includes a meter configured to receive the test strip, wherein the meter is configured to read the test strip and detect a level of cotinine.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Inventors: Keith Moskowitz, Christopher Dailey, Charles Xie, Richard Lee
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Publication number: 20160349253Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.Type: ApplicationFiled: July 11, 2016Publication date: December 1, 2016Applicant: Meso Scale Technologies, LLC.Inventors: Sudeep Kumar, George Sigal, Michael Tsionsky
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Publication number: 20160349254Abstract: The present invention relates to an in vitro method for the prediction and/or the diagnose of lupus nephritis in subjects affected or potentially affected by systemic lupus erythematosus, an in vitro method for monitoring a therapy against lupus nephritis in subjects affected or potentially affected by systemic lupus erythematosus and a kit for the prediction of the progression of lupus nephritis and/or for monitoring a therapy against lupus nephritis in subjects affected or potentially affected by lupus erythematosus.Type: ApplicationFiled: January 19, 2015Publication date: December 1, 2016Applicant: PAD 4 DI MARIA ADELE SILVIA DENEGRI S.A.S.Inventors: Gian Marco GHIGGERI, Luca GHIGGERI
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Publication number: 20160349255Abstract: The present invention relates to the field of immunological methods, more precisely to the field of detection methods for antibodies against double-stranded DNA (dsDNA) for diagnostics of chronic autoimmune diseases, such as systemic lupus erythematosus (SLE). The fluorometric immunoassay method for detection of anti-dsDNA solves the technical problem of designing a method for detection of the aforesaid antibodies, which would be faster, cheaper and less toxic as the standard Farr-RIA method, but would have the same diagnostic specificity (which is 100%) and improved diagnostic sensitivity (for 3%). Detection of anti-dsDNA is based on detection of fluorescence in two fractions of samples, in the supernatant and in the sample with a precipitate, which contains immune complexes composed of added dsDNA and anti-dsDNA present in the patient's serum, wherein the detected fluorescence is a consequence of binding fluorescent dyes with dsDNA bound in the complexes or with free dsDNA.Type: ApplicationFiled: February 3, 2015Publication date: December 1, 2016Applicant: UNIVERZITETNI KLINICNI CENTER LJUBLJANAInventors: Tanja Kveder, Katja Lakota, Tinka Svec, Sasa Cucnik, Polona Zigon, Ales Ambrozic, Snezna Sodin-Semrl, Borut Bozic, Matija Tomsic
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Publication number: 20160349256Abstract: The present invention involves the identification of biomarkers that are predictive of impeding systemic lupus erythematosus (SLE) disease flare. Methods for treating patients so identified are also provided.Type: ApplicationFiled: August 11, 2016Publication date: December 1, 2016Inventors: Judith A. James, Melissa E. Munroe
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Publication number: 20160349257Abstract: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated.Type: ApplicationFiled: August 12, 2016Publication date: December 1, 2016Inventors: Julio Bai, Alessio Fasano, Blake Paterson, Alicia Sambueli
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Publication number: 20160349258Abstract: A photo-electrochemical bio-sensor uses a semiconductor heterostructure located in an etching solution. An outer layer of the heterostructure is functionalized, such as with a self-assembled monolayer, to provide adherence of a charged molecule of interest. When contacted by a test solution, the functionalization immobilizes a quantity of the molecule that corresponds to its concentration in the test solution. The heterostructure undergoes photocorrosion when illuminated by a laser at a rate corresponding to the quantity of immobilized charged molecules. The rate of photocorrosion is monitored to determine the concentration of the molecule in the test solution. The monitoring may make use of a photoluminescent material in the heterostructure that emits photoluminescence in response to the laser illumination. The photoluminescence changes with the advancement of the photocorrosion, and the change is therefore indicative of the concentration of the molecule in the test solution.Type: ApplicationFiled: February 2, 2015Publication date: December 1, 2016Inventor: Jan J. DUBOWSKI
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Publication number: 20160349259Abstract: Improved methods of treatment are provided for patients suffering from cancer. The methods identify whether a tumor will be responsive to treatment with a therapeutic regime that includes anti-Her2 therapeutic agents. A specific Her2 fragment peptide is precisely quantitated by SRM-mass spectrometry directly in tumor cells collected from tumor tissue that was obtained from a cancer patient and compared to a reference level in order to determine if the cancer patient will positively respond to treatment with a therapeutic agent that specifically targets the Her2 protein.Type: ApplicationFiled: May 31, 2016Publication date: December 1, 2016Inventors: Yung-Jue BANG, Todd HEMBROUGH, Eunkyung AN
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Publication number: 20160349260Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.Type: ApplicationFiled: August 11, 2016Publication date: December 1, 2016Applicant: Incyte CorporationInventors: Preeti G. LAL, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
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Publication number: 20160349261Abstract: The disclosure provides diagnostic and therapeutic agents for chronic lymphocytic leukemia (CLL). Further provided are biomarkers and a biomarker panel comprising G-protein coupled receptors (GPCRs) specifically expressed by CLL cells. Methods for diagnosing a disease stage of a CLL patient, progression, or prediction of clinical course and drug selection for the CLL patient, as well as methods for treating CLL, by targeting these GPCR biomarkers are also provided.Type: ApplicationFiled: April 8, 2014Publication date: December 1, 2016Inventors: Paul Insel, Fiona Murray, Lingzhi Zhang, Trishna Katakia, Andrea Wilderman, Charles Gray
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Publication number: 20160349262Abstract: The disclosure provides methods for automated characterization of circulating tumor cells (CTCs), for example using automated tissue strainers. In specific examples, such methods permit characterizing a prostate cancer sample by simultaneously or contemporaneously detecting ERG rearrangements and PTEN deletions in the same CTC. Also provided are kits that can be used with such methods.Type: ApplicationFiled: March 2, 2016Publication date: December 1, 2016Inventors: Gary Pestano, Ryan Dittamore, Karl Garsha, Michael Otter, Chol Steven Yun, Alexandra Dea Nagy
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Publication number: 20160349263Abstract: The present invention provides compositions and methods of detecting prostate cancer in the body fluids or tissues of patients. Prostate cancer is detected by measuring the level of glypican-1 in a body fluid sample. In one embodiment prostate cancer is detected by contacting a body fluid sample with an anti-glypican-1 antibody, such as MIL-38. The invention includes kits for detection of prostate cancer in a body fluid sample, comprising an anti-glypican-1 antibody and glypican-1 standards.Type: ApplicationFiled: January 16, 2015Publication date: December 1, 2016Inventors: Bradley WALSH, Douglas CAMPBELL, Irene JUSTINIANO FUENMAYOR, Aline NOCON, Julie SOON, Quach TRUONG, Sandra WISSMUELLER, Pamela RUSSELL
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Publication number: 20160349264Abstract: Methods of isolating, enriching, capturing, identifying, or detecting the presence of, cancerous cells in a sample, e.g., a blood sample from a subject, by detecting the presence of one or more cancer cell surface markers selected from the group consisting of cadherin 1 (CDH1), CDH2, CDH3, CDH4, CDH5, CDH9, CDH11, CDH17, CDH19, protocadherin 9 (PCDH9) and/or PCDH beta 13 (PCDHb13), and optionally an additional cancer cell surface marker, e.g., EpCAM, MUC1, EphB4, EGFR, CEA, and/or HER2.Type: ApplicationFiled: August 15, 2016Publication date: December 1, 2016Inventors: Shyamala Maheswaran, David Tsai Ting, Daniel A. Haber
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Publication number: 20160349265Abstract: The current disclosure provides for specific peptides from the Insulin Receptor Substrate 1 (IRS1) protein and the derived ionization characteristics of those peptides that are particularly advantageous for quantifying the IRS1 directly in formalin fixed biological samples by the method of Selected Reaction Monitoring (SRM) mass spectrometry. Such fixed biological samples include: formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and formalin fixed and paraffin embedded tissue culture cells. IRS1 protein is quantitated in biological samples by the method of SRM/MRM mass spectrometry by quantitating one or more of the peptides described herein. The peptides can be quantitated if they reside in a modified or an unmodified form. Examples of potentially modified forms of an IRS1 peptides include those bearing phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence.Type: ApplicationFiled: August 15, 2016Publication date: December 1, 2016Inventors: David KRIZMAN, Todd HEMBROUGH, Sheeno THYPARAMBIL
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Publication number: 20160349266Abstract: An object is to provide an immunoassay method requiring neither a solid-phase immobilization step nor a washing step, enabling quick and simple quantitative measurement of a target substance in a liquid phase and capable of visualizing an antigen.Type: ApplicationFiled: June 16, 2016Publication date: December 1, 2016Applicant: USHIO DENKI KABUSHIKI KAISHAInventors: Hiroshi Ueda, Ryoji Abe, Masaki Ihara, Hiroaki Takagi
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Publication number: 20160349267Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: August 17, 2016Publication date: December 1, 2016Inventors: Brent S. GAYLORD, Glenn P. BARTHOLOMEW, Russell A. BALDOCCHI, Janice W. HONG, William H. HUISMAN, Yongchao LIANG, Trung NGUYEN, Lan T. TRAN, Jean M. WHEELER, Adrian Charles Vernon PALMER, Frank Peter UCKERT
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Publication number: 20160349268Abstract: The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a capture compound CC and the target compound T and a carrier compound CCB, carrying out a division step, in which a cleavable function F is cleaved, and a division compound DC is produced, and isolation and/or characterisation of said division compound DC. The invention relates further to a carrier compound CCB, a capture compound CC, a precursor compound PC and a division compound DC.Type: ApplicationFiled: January 28, 2015Publication date: December 1, 2016Applicant: CAPROTEC BIOANALYTICS GMBHInventors: Hubert KOSTER, Mathias DREGER, Simon MICHAELIS, Thomas LENZ, Jelena MILIC, Michael SEFKOW
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Publication number: 20160349269Abstract: The application discloses, compositions, methods, systems, and apparatuses for rapid sequence analysis of proteins, including location of post-translational modifications and disulfide bonds, is described. Limited digestion of fully denatured antibody occurs in seconds by flowing sample in 8 M urea at constant pressure through a micro column reactor containing immobilized aspergillopepsin I, resulting in a product mixture containing 3-10 kDa peptides, which is then fractionated by capillary column chromatography and analyzed by both electron transfer dissociation (ETD) and collision activated dissociation mass spectrometry. This method provides 95% sequence coverage of a mAb and detects numerous post-translational modifications. For disulfide bond location, native mAb is subjected to longer digestion times. Release of disulfide containing peptides from accessible regions of the folded protein occurs with short digestion times.Type: ApplicationFiled: February 4, 2015Publication date: December 1, 2016Inventors: Donald F. Hunt, Weihan Wang, Lichao Zhang
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Publication number: 20160349270Abstract: This application describes an assay for immunoprecipitation that is quick, reliable, easy to perform, and that can be used in a high throughput fashion because it does not rely on western blotting analysis even if it can be included in a standard IP/WB procedure without affecting the output of the analysis. Because of these features the FLIP assay is ideal for the high-throughput screening of IP-grade antibodies. Here we present the basic concept of the invention and the application of the FLIP in high-throughput screening such as the quick identification of IP-proficient mouse monoclonal antibodies.Type: ApplicationFiled: December 16, 2014Publication date: December 1, 2016Inventors: Jef BOEKE, Paolo MITA
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Publication number: 20160349271Abstract: Described herein are methods for diagnosing or assessing and treating an individual for cardiovascular disease based on the individual's normalized level of biomarkers. For example, a level of Lp-PLA2 mass or Lp-PLA2 activity normalized to a level of Lp-PLA2 total mass (e.g. total mass) may be used. Described herein are new and more accurate diagnostic indicators to help identify and stratify individuals having cardiovascular disease or at risk for cardiovascular disease, as well as methods for treating such patients. The methods and techniques described herein may be especially useful for detecting early stages of cardiovascular disease, and may be particularly useful for distinguishing a person having cardiovascular disease from a person without cardiovascular disease.Type: ApplicationFiled: February 13, 2015Publication date: December 1, 2016Inventors: Shaoqiu ZHUO, Maria Teresa JALILIE
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Publication number: 20160349272Abstract: Neuronal damage is detected by providing a biological sample derived from the subject, detecting in the sample the presence of a neurofilament subunits or their breakdown products, and correlating the presence and level of the neurofilament subunits and their breakdown products detected with the degree of neuronal injury.Type: ApplicationFiled: November 21, 2014Publication date: December 1, 2016Inventors: Gerry Shaw, Brian Pike
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Publication number: 20160349273Abstract: A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising: providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape; adding an active ingredient to be analyzed to the sample solution; separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape; optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks; determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.Type: ApplicationFiled: June 25, 2014Publication date: December 1, 2016Inventors: Luitgard NAGEL_STEGER, Oleksandr BRENER, Lothar GREMER, Dieter WILLBOLD
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Publication number: 20160349274Abstract: Embodiments of the present invention provide methods for diagnosing schizophrenia, schizo-affective disorder and/or psychosis in an individual or predicting risk of the individual developing schizophrenia, schizo-affective disorder or psychosis, by determining values for one or more markers in each of five domains, namely a neurotransmitter domain, an oxidative stress domain, a nutrition-biochemistry domain, a visual processing domain and an auditory processing domain.Type: ApplicationFiled: December 23, 2014Publication date: December 1, 2016Inventor: Stephanie Sue WILLIAMS
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Publication number: 20160349275Abstract: The present invention concerns subject matter connected to or making use of lgLON5, lgLON5 fragments and variants of lgLON5 and lgLON5-fragments. In particular the present invention relates to a use of a polypeptide comprising one or more sequences of IgLON5, an lgLON5-fragment or a variant thereof for the diagnosis of a disease, in vitro methods for diagnosing such a disease, a polypeptide comprising one or more sequences of lgLON5, an lgLON5-fragment or a variant thereof or a nucleic acid encoding said polypeptide for use in the treatment of a disease, a pharmaceutical composition comprising such polypeptide, a method for treating such a disease, an autoantibody binding to IgLON5, an lgLON5-fragment or a variant thereof, a method for isolating such autoantibody, a medical or diagnostic device comprising such autoantibody or such polypeptide and a test kit for the diagnosis of a disease, which test kit comprises such autoantibody and/or such polypeptide.Type: ApplicationFiled: February 6, 2015Publication date: December 1, 2016Applicants: INSTITUT D'INVESTIGACIONES BIOMÈDIQUES AUGUST PII SUNYER, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, UNIVERSITAT DE BARCELONA, HOSPITAL CLÍNIC DE BARCELONAInventors: Josep DALMAU, Francesc GRAUS
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Publication number: 20160349276Abstract: The present invention relates to the use of Sortilin as a biomarker. In particular, Sortilin is useful as a biomarker for affective disorders. In one aspect of the invention Sortilin may be used to aid the diagnosing and to monitor disease progression in bipolar disorder and unipolar depression by measuring Sortilin levels. The invention further provides methods for informing the choice of treatment of bipolar disorder and unipolar depression by determining the levels of Sortilin.Type: ApplicationFiled: February 6, 2015Publication date: December 1, 2016Applicant: H. Lundbeck A/SInventors: Jesper Lundhede Jepsen, Anders Nykjær, Niels Peter Ole Mors, Claus Munck Petersen, Søren Dinesen Østergaard, Simon Glerup
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Publication number: 20160349277Abstract: The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or ?,?-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or ?,?-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.Type: ApplicationFiled: February 9, 2015Publication date: December 1, 2016Applicant: KRATOS ANALYTICAL LIMITEDInventors: Gerald STUBIGER, Omar BELGACEM
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Publication number: 20160349278Abstract: An analytical laboratory system and method for processing samples is disclosed. A sample container is transported from an input area to a distribution area by a gripper comprising a means for inspecting a tube. An image is captured of the sample container. The image is analyzed to determine a sample container identification. A liquid level of the sample in the sample container is determined. A scheduling system determines a priority for processing the sample container based on the sample container identification. The sample container is transported from the distribution area to a subsequent processing module by the gripper.Type: ApplicationFiled: August 12, 2016Publication date: December 1, 2016Inventors: Charles W. Johns, Joseph F. Quint, Chi S. Chen
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Publication number: 20160349279Abstract: Transport part transports first sample container to sample aspiration position. Setting part is set second sample container that accommodates sample to be measured with priority over measurement of the sample in first sample container. Nozzle is capable of moving for aspirating sample from first sample container at sample aspiration position, and aspirating the sample from second sample container set in setting part. Detector detects components of the sample aspirated by nozzle. Controller controls transport part such that first sample container moves to position distant from sample aspiration position, when first sample container has been transported to sample aspiration position and when the sample aspiration from the second sample container using the nozzle is required. Controller executes control such that nozzle that has aspirated the sample from second sample container moves above sample aspiration position in state in which first sample container is distant from sample aspiration position.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Applicant: SYSMEX CORPORATIONInventors: Hiroki KOIKE, Yousuke MATSUI, Go SENDA, Hiroo TATSUTANI, Yuichiro OHMAE, Atsushi KUMAGAI, Tomoyuki ASAHARA
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Publication number: 20160349280Abstract: The present disclosure relates to an inertia measurement module for an unmanned aircraft, which comprises a housing assembly, a sensing assembly and a vibration damper. The vibration damper comprises a first vibration-attenuation cushion; and the sensing assembly comprises a first circuit board, a second circuit board and a flexible signal line for connecting the first circuit board and the second circuit board. An inertia sensor is fixed on the second circuit board, and the first circuit board is fixed on the housing assembly. The inertia measurement module further comprises a weight block, and the second circuit board, the weight block, the first vibration-attenuation cushion and the first circuit board are bonded together. The present disclosure greatly reduces the influence of the operational vibration frequency of the unmanned aircraft on the inertia sensor and improves the measurement stability of the inertia sensor.Type: ApplicationFiled: August 8, 2016Publication date: December 1, 2016Inventors: Tao Wang, Tao Zhao
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Publication number: 20160349281Abstract: A Doppler shift frequency measuring device is provided, which includes a plurality of transmitters respectively configured to transmit a transmission wave, a plurality of receivers provided corresponding to the transmitters, respectively, and configured to receive reception waves that are reflection waves caused by the transmission waves from the transmitters, respectively, and a reception signal processor configured to calculate Doppler shift frequencies of the reception waves by processing reception signals obtained based on the reception waves received by the receivers.Type: ApplicationFiled: May 18, 2016Publication date: December 1, 2016Inventor: Satoshi Kawanami
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Publication number: 20160349282Abstract: A motion measuring device includes a processor which measures a motion with the use of a signal generated by a sensor . The processor switches an item for the measurement of motion to another item for measurement of motion according to a site of installation of the sensor.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Applicant: SEIKO EPSON CORPORATIONInventors: Naoki GOBARA, Akifumi HAYASHI
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Publication number: 20160349283Abstract: The accelerometers disclosed herein provide excellent sensitivity, long-term stability, and low SWaP-C through a combination of photonic integrated circuit technology with standard micro-electromechanical systems (MEMS) technology. Examples of these accelerometers use optical transduction to improve the scale factor of traditional MEMS resonant accelerometers by accurately measuring the resonant frequencies of very small (e.g., about 1 ?m) tethers attached to a large (e.g., about 1 mm) proof mass. Some examples use ring resonators to measure the tether frequencies and some other examples use linear resonators to measure the tether frequencies. Potential commercial applications span a wide range from seismic measurement systems to automotive stability controls to inertial guidance to any other application where chip-scale accelerometers are currently deployed.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Inventors: Suraj Deepak Bramhavar, Paul William Juodawlkis