Abstract: The invention relates to a boot remover (10) for removing a protective needle boot (11) from a drug delivery device (1), wherein the boot remover (10) is substantially sleeve shaped with an internal diameter and a length adapted to receive and substantially cover a needle shield (4), wherein the boot remover (10) is arranged to engage the protective needle boot (11) when attacked to the drug delivery device (1). Furthermore, the invention relates to a drug delivery device (1) comprising a boot remover (10).

Abstract: The invention refers to a needle cap remover (7) for a needle cap (5.1) of a drug delivery device (2). The needle cap remover (7) comprises a body (8) having a material which differs from the material of the needle cap (5.1) or of a rigid needle shield (5) encasing the needle cap (5.1) in at least one parameter, wherein a body portion (8.1), which covers the needle cap (5.1) or the rigid needle shield (5) encasing the needle cap (5.1), is adapted to capture the needle cap (5.1) or the rigid needle shield (5) encasing the needle cap (5.1) by a positive and/or non-positive connections before or during removing of the needle cap (5.1) and is adapted to shrunk when a pulling force is applied.

Abstract: The invention refers to a needle safety device (4) for a drug delivery device (1) comprising a needle cap remover (8) adapted to capture a needle cap (6) by a positive and/or non-positive connection, wherein the needle cap remover (8) comprises a top end (8.3), a needle shield (7) adapted to cover a needle (5) of the drug delivery device (2) before and after injection, wherein the needle shield (7) comprises a needle shield end (7.4) adapted to engage an injection site, and at least one blocking pin (9) which inwardly extends from the top end (8.3) and/or the needle shield end (7.4) into the needle cap remover (8) and/or into the needle shield (7).

Abstract: An injection device is disclosed which comprises a housing (140, 240, 440, 740) for a plurality of cartridges (110,310,410,810) each containing a medicament to be administered to a patient. A plurality of needles (120, 220, 320, 420, 720, 820) may be provided in communication with the plurality of cartridges. A delivery mechanism is arranged to deliver medicament through the plurality of cartridges via the plurality of needles. An injection device may comprise a drive member (130) having a cam surface (136) configured to engage a surface of a carrier (150) and rotate the carrier about a pivot (152) and at least one plunger (134) arranged to engage a cylinder in the cartridge.

Abstract: A device that is used to reduce the pain of a needle stick to a person, the device having a casing containing a vibratory device and a temperature reducing device, and a method for using the device to reduce the pain of a needle stick by applying both thermal and vibration analgesia to a subject during a needle stick.

Abstract: A drug delivery system includes a reservoir and a drug delivery device coupled to the reservoir. The drug delivery device also may include at least one temperature-sensitive component and a lock having locked and unlocked states. The system further includes an output device, and a controller coupled to the lock and the output device. The controller may also include a temperature sensor, or may be coupled to the temperature sensor. The controller is programmed or configured to determine if the temperature of a drug in the reservoir or of the temperature-sensitive component exceeds an upper limit or is below a lower limit, and to activate the lock in either event. The controller is also programmed or configured to determine, directly or indirectly, if the temperature subsequently is between the upper and lower limits, and to unlock lock as a consequence.

Abstract: An automatic injection device including a reusable driving assembly having a forward injection end and an engagement element and a disposable cassette assembly including an injectable liquid to be injected at an injection site, wherein the disposable cassette assembly is removably insertable into the reusable driving assembly at the forward injection end and is removably retained within the reusable driving assembly by snap fit engagement therewith, the snap fit engagement being effected at least partially by the engagement element, which is displaced rearwardly by insertion of the disposable cassette assembly in the reusable driving assembly.

Abstract: Inhalator (50) comprising an aerosol generator (64) configured to generate an aerosol by nebulizing a fluid and a controller (24) configured to control operation of the aerosol generator and a housing (11, 51) accommodating at least the aerosol generator and the controller, the housing having a base (12) for supporting the housing on a horizontal surface, wherein a portion (35) of the housing accommodating at least a portion of the controller is arranged further away from the base than the aerosol generator as seen in a vertical direction, when the base is supported on the horizontal surface.

Abstract: Devices and methods for sequential aerosolized administration of pharmaceutical agents. A portable device may be used to administer an initial dose of an active formulation comprising at least one first pharmaceutical agent and a subsequent dose of an active formulation comprising at least one second pharmaceutical agent that may have the effect of countering, enhancing, or mitigating the first pharmaceutical agent.

Abstract: Methods, systems, and devices are provided for generating a mist. In one embodiment, a fluid delivery device is provided that includes a housing, a fluid vaporizer disposed within the housing and configured to receive fluid and to produce an aerosol mist of liquid particles from the fluid, and a pump configured to accelerate the aerosol mist produced by the fluid vaporizer. Methods are provided for producing a mist, and the methods can include delivering a fluid to a fluid vaporizer that generates a first mist. The fluid vaporizer delivers the mist to a pump that generates a second mist from the first mist.

Abstract: A nebulizer kit includes an atomizer generating an aerosol, and a particle sorting route communicating with the atomizer and sorting liquid particles in the aerosol to adjust a particle diameter distribution thereof, and guiding the aerosol to a discharge port. The particle sorting route includes a first particle sorting route with a uniform cross-sectional area in the first direction and a second particle sorting route with an inner end wall that curves from the first direction toward a second direction included in the same plane as the first direction. The first particle sorting route guides the aerosol to the second particle sorting route in the first direction, and the inner end wall of the second particle sorting route guides the aerosol in the second direction while aerosol particles with a certain particle diameter or more are attached thereto.

Abstract: A method of purifying at least one of THC and CBD from a cannabis-containing composition includes heating the cannabis-containing composition to a temperature sufficient to volatilize at least one of THC and CBD into a vapor and condensing the vapor on a substrate. A drug delivery cartridge can include a substrate coated with at least one of THC and CBD and configured to allow for passage of air through the cartridge to volatilize at least one of THC and CBD for inhalation by a user to induce a medicinal or therapeutic effect to the user. A drug delivery system can be used with the drug delivery cartridge and can include a heating element to volatilize at least one of THC and CBD from the coated substrate into a vapor for inhalation.

Abstract: A system and method for communicating data from a medical device to a lighting device is provided. The system may include the medical device, the lighting device, and/or one or more interface devices. The medical device may be configured to transmit data to the lighting device, which for example, may include information relating to the medical device, dosage information, diagnostic data, medical device training feedback, health monitoring information, and/or air quality information. The lighting device may be configured to receive data from the medical device and control one or more lighting characteristics based on the received data. A characteristic of the light may include one or more of color, color temperature, intensity, flashing or steady-state, on or off, and/or the like. The system may provide for a home based adherence and/or compliance monitoring system, in which a patient's interaction with a medical device may be monitored and an alert/indication provided.

Abstract: The invention relates to a grid element for an inhaler which can be arranged in an air duct between a mouthpiece and a capsule chamber of the inhaler, it being possible for turbulence to be generated by means of the grid element in an airflow passing through the air duct. The grid element is characterised in that it comprises a preferably planar grid-type portion having a grid front side which points towards the capsule chamber and a grid rear side, at least one protruding element being arranged on the grid front side, by means of which a capsule that can be arranged in the capsule chamber can be loosely supported.

Abstract: The invention relates to a method for the manufacture of a pressurised Metered Dose Inhaler (pMDI) and components for use in said method, in particular, a pMDI compatible tablet (i.e. one that is able to be dispersed or disintegrates within a liquid phase, such as a propellant, used in a pMDI formulation) which contains at least one active pharmaceutical ingredient (API) and, optionally, one or more excipients.

Abstract: An adapter for fitting to a drug delivery device, the adapter including: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of said drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. A drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.

Abstract: A ventilator with a safe standby mode is provided. The safe standby mode allows a user to disconnect a patient from the ventilator, without the ventilator generating alarms and while maintaining previously entered ventilation parameters. In addition, while in the safe standby mode, a patient connection status is monitored, and a ventilation mode is entered automatically if the ventilator determines that a patient is connected to the ventilator while the ventilator is in the safe standby mode.

Abstract: A pressure support system includes a pressure generating device, an airflow path, and a control system. The control system is structured to determine a first measurement indicative of an amount of water vapor in the airflow path or an amount of condensation in the airflow path and generate a number of control signals structured to control an environmental control device structured to control an environmental parameter in an environment including the pressure support system, wherein the control signals are generated based on at least the first measurement and are configured to cause the environmental control device to adjust the environmental parameter in a manner that will reduce a degree or a likelihood of rainout in the airflow path, and transmit the control signals to the environmental control device so that it may be controlled to reduce the degree or likelihood of rainout.

Abstract: A system for ventilating lungs of a subject is disclosed herein. The system includes a control unit configured to control operation of the system. The system also includes a machine ventilator circuit configured to assist the breathing functions of the subject, the machine ventilator circuit includes an inspiration delivery unit, and an expiration circuit. The system also includes a manual ventilation circuit comprising a manual bag guiding a gas from the manual bag wherein a gas flow is guided out from the manual bag to assist an inspiration phase, a gas flow is received to fill the manual bag during an expiration phase, and wherein the gas flow received to fill the manual bag during the expiration phase at least partially comprises the gas flow guided to assist the inspiration phase.

Abstract: The invention relates to a speech valve for laryngectomy or tracheotomy patients, comprising a cover element, a housing part and a filter, the cover element comprising a piston-shaped closure element and said closure element being connected to the cover element to form one piece therewith. The cover element comprises an elastic material and by deforming at least part of the cover element the closure element closes the speech valve distally of the filter.

Abstract: An oxygen cord retractor and organizing apparatus is described. The apparatus is equipped with a housing, swivel base, a string or rope, spring-based retraction system, and clips. The oxygen cord retractor is configured to keep oxygen cord, hose, or tubing in a safely organized and coiled state both when stored and during use. The string or rope is disposed to extend within the coiled oxygen hose, and is configured to extend and retract via the spring-based retraction system housed within the housing of the apparatus. An oxygen cord organizer is disposed atop the housing, which facilitates the organization of the oxygen cord when not in use, and functions as a mounting point for the oxygen cord to the oxygen concentrator or oxygen cylinder/tank. The string is configured to extend and retract with ease from the housing via the spring-based retraction system, and remains taught during use.

Abstract: An electronic apparatus including an adjustment determination unit structured to receive patient interface device information for a patient interface device including one or more adjustable features and a 3-D model of a patient's face, and to calculate adjustment information for the patient interface device corresponding to the patient's face using the patient interface device information and the 3-D model of the patient's face and an output unit structured to output the adjustment information.

Abstract: A respiratory mask can be used to provide therapy to patients who also require a nasogastric (NG) tube. The mask seal can include a path that is designed to deform around an NG tube or other without lifting the mask away from a patient's face. The deforming path can help to minimize gaps that form between the patient's face and the mask seal as a result of the tube, thus reducing leaks and improving the efficacy of the treatment.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: The present invention provides for an improved method of determining a water out condition in a humidified gases supply apparatus. The method includes a two step process including a primary determination of a water out condition and a secondary determination of a water out condition. This primary determination is made during observation of the normal operation of the apparatus. During the secondary determination the method takes temporary control over the humidifying part of the apparatus. The secondary determination confirms or contradicts the primary determination.

Abstract: A system and method for promoting enhanced healing of a medical patient includes a patient room having accommodations for the medical patient, a central computer connected to a media server, a main display located in the patient room, the main display connected to the central computer and including at least a navigation pane and a content pane, an audio system connected to the central computer and capable of providing sound to the patient room, and a remote unit directly accessible to the medical patient, the remote unit having a capability to control the central computer and a content of the main display and a content of the audio system.

Abstract: A wire organizer includes a basin having an inner surface that defines a reservoir. The reservoir has a liquid therein. A hub is positioned within the reservoir. A plurality of spools are positioned on the hub such that the spools are spaced apart from the inner surface and are rotatable relative to the basin. The spools each have a wire wrapped around each of the spools. At least a portion of each of the wires extends through the liquid. Systems and methods are disclosed.

Abstract: A venous catheter having a catheter tip comprising recessed diffusion holes for increasing the snag-resistance of the venous catheter. The invention further provides systems and methods for providing axial ridges interposed between diffusion holes for increasing the rigidity of the vented catheter tip.

Abstract: A catheter is described having one or more markers and one or more marker sections.

Abstract: A method and apparatus for fluid delivery enables navigation through tortuous, spatially restricted body anatomy to access narrow diameter body lumens for the continuous delivery of fluids, including therapeutic fluids, to the lumen in an atraumatic manner that avoids damage to the body lumen. The fluid delivery device can have a flexible conduit having a proximal end, a distal end, and a lumen extending along an interior of the flexible conduit providing a fluid flow path between the proximal and distal ends, where the lumen transitions into a micro-lumen exiting through a port through which a high concentration of fluid injected into the lumen exits laterally out along an image viewable zone at the distal end of the flexible conduit. The flexible conduit has a maximum outer diameter sized sufficient to navigate narrow diameter body lumens.

Abstract: A catheter assembly with a catheter, an outer casing positioned over the proximal end and at least part of the hub body of the catheter hub. The outer casing being pliable and has an interior cavity and a septum at a proximal end thereof. A needle hub removably coupled to a proximal end of the catheter hub with the outer casing wedged between the catheter hub and the needle hub. The needle hub has a proximal interior cavity and a shroud with a distal opening. A needle projects distally from the needle hub through the septum of the outer casing and has a needle tip extending out a distal opening of a catheter tube in a ready to use position.

Abstract: A torque-limiting device may include a shaft extending axially through upper and lower shanks, a spring, and a nut to an end opening of a handle. The upper and lower shanks may be under a force from the spring and further configured to selectively engage within a predetermined torque limit and disengage at above the predetermined torque limit. Accordingly, the shaft may receive torque up to the predetermined limit as provided by a user operating a handle of the torque-limiting device. The torque-limiting device may be disposable, reusable, economical, and have high torque capabilities. The shaft may be of a plastic material and include a lumen extending there through, and through which a variety of devices and materials may be delivered to a workpiece.

Abstract: An instrument driver comprises opposing rotatable gripping pads. Each of the gripping pads includes an outer circular rim and a center hub. The pads are configured for applying a gripping force to an elongated member. The instrument driver further comprises shafts affixed to the center hubs, and a driver assembly configured for rotating at least one of the shafts, thereby causing the pads to rotate in opposite directions to linearly translate the gripped member. Each of the pads further includes a framework for partially collapsing in response to the gripping force, such that portions of the rims flatten to contact each other. Each rim has a concave gripping surface in order to facilitate vertical centering of the member between the pads. Each of the pads further includes a pair of upper and lower sprockets for interlacing with each other to prevent the elongated member from slipping out between the pads.

Abstract: One embodiment is directed to a system for creating translumenal vascular access, comprising a dilator adaptor member having proximal and distal ends and defining a dilator adaptor lumen therethrough, wherein the dilator adaptor lumen is defined by an inner diameter profile sized to accommodate insertion of one or more portions of a guidewire, and wherein the dilator adaptor is further defined by an outer diameter profile sized to accommodate at least partial insertion of the proximal end of the dilator adaptor into a dilator member lumen formed through a dilator member, the dilator member being coupleable to an introducer catheter member through an introducer member lumen formed through the introducer member.

Abstract: A method of manufacturing a medical device is disclosed. The method comprises laser cutting a tubular member. The tubular member may have an inner surface, an outer surface and a tubular wall defining a thickness extending therebetween. The method may also include laser cutting the member. Laser cutting may include removing a portion of the thickness of the tubular wall at one or more discrete locations along the tubular wall. The method may also include chemically etching the one or more discrete locations to form a slot within the tubular wall at the one or more discrete locations along the tubular member.

Abstract: An intravascular balloon catheter device is disclosed having an inner member, an outer member disposed about the inner member and further comprising a balloon. A sheath is disposed about the outer member that moves relative to the balloon so as to selectively expose some or all of the balloon for inflation. A clamp may be used to selectively secure the sheath at a desired position relative to the balloon. A balloon recapture element may permit incremental adjustment to the balloon length and facilitate balloon recapture.

Abstract: A non-compliant medical balloon may be changed from a deflated state to an inflated state by increasing pressure within the balloon. The non-compliant medical balloon is composed of a woven fabric layer composed of at least two woven fabric fibers forming an angle. The angle remains substantially unchanged when the balloon changes from a deflated state to an inflated state.

Abstract: Described here are devices and methods for dilating tissues. In other variations, the dilatation device comprises a slotted or expandable tube that may expand to dilate tissue. In still other variations, the dilatation device comprises two or more hinged or movable plate members that separate to dilate tissue. In yet other variations, the dilation device may comprise one or more flexible members. One or more portions of the dilatation device may be detachable from the device in the body, and dilatation device may release one or more implants into the body. In some of these variations, the dilatation device may additionally be used to expand one or more implants or other devices within the body. In some variations the dilatation device may release one or more substances that may hold dilated tissue in a dilated configuration.

Abstract: Systems for delivery of therapeutic agents and related methods are disclosed. A sensing system is configured to detect a chemical in the vicinity of a patient and transmit a signal to a controller upon detection. A controller is configured to release a therapeutic agent which is transported to the site of interest. The controller communicates with an electronic medical records database, an alarm and a nurse call system.

Abstract: A device for inserting needles of a microneedle patch into a skin includes a housing. The housing includes a support portion for supporting a microneedle patch, a pressure-receiving portion to which the user applies a force to press the microneedle patch against the skin, and a plurality of leg portions each having at its one end a connecting portion connected to the pressure-receiving portion and having at its other end a tip portion coming into contact with the skin. The housing is designed to deform when a force is applied to the pressure-receiving portion, to cause a tension in a portion of the skin facing the support portion.

Abstract: A micro needle stamp comprises: a micro needle unit having a plurality of micro needles implanted therein; a main cover receiving and slidably supporting the micro needle unit; an auxiliary cover in which a plurality of openings are formed to correspond to the plurality of micro needles, and which is slidably coupled to the outer surface of the main cover while restricting the main cover from moving backward with respect thereto; a first resilient body interposed between the micro needle unit and the main cover; and a second resilient body interposed between the main cover and the auxiliary cover.

Abstract: A microneedle container includes a housing that houses a microneedle and a cover that covers the microneedle. The microneedle includes a base having a first surface on which a projection is formed and a second surface supported by a supporting portion of the housing. The base has an abutted portion on the first surface where the projection is not formed, and the cover has an abutment portion that faces the abutted portion, and a facing portion that faces the projection. A distance between the abutment portion and the facing portion is larger than that between the abutted portion and a distal end of the projection in a direction in which the projection extends. A distance between the abutment portion and the supporting portion is smaller than a sum of a distance between the abutted portion and the second surface and a distance between the abutted portion and the distal end.

Abstract: An improved tattooing needle assembly and support assembly for the needle assembly are provided. The needle assembly includes a needle component extending through a main case into an aperture assembly. The needle component is configured to reciprocate between a stowed configuration, in which a tip of the needle component is positioned within the aperture assembly, and a deployed configuration, in which the tip extends beyond the aperture assembly. A tattooing machine causes the needle component to move to the deployed configuration while opposed magnets bias the needle component back towards the stowed configuration. Using a needle protection sleeve, the needle assembly can be removed from and/or installed onto a tattooing machine without requiring a user to come into direct contact with the needle assembly. By securing the needle protection sleeve to a support assembly, the removal and/or installation of the needle assembly becomes a one-hand operation.

Abstract: An implantable venous device is provided with a catheter including a passage; a locking nut including a channel for receipt of the catheter, and an annular convex end; an injection seat including a base, a peripheral wall, and a mounting member projecting out of the wall; a connecting tube projecting out of the mounting member and including a bulged central portion and an annular curved outward end wherein the locking nut is secured onto the bulged central portion; a base member including a groove; a housing including a top opening, a clamping portion on a periphery of the top opening, and a passageway through a bottom edge for receipt of the base member wherein the injection seat is fastened in the housing, and the locking nut is in the groove; and an implant member in the top opening and including a peripheral flange urged downward by the clamping portion.

Abstract: The male connector (1) includes a connector body (10) and a lock nut (50). The connector body (10) includes a male luer (11), first female threading (41) that surrounds the male luer (11), a base end portion (20) that is inserted into a tube (8), a fixed protrusion (21) formed on the base end portion (20), and a spiral protrusion (32) between the male luer (11) and the base end portion (20). The lock nut (50) includes second female threading (52) that is screwed together with the spiral protrusion (32). When the spiral protrusion (32) and the second female threading (52) are screwed together, the base end portion (20) and the lock nut (50) clamp the tube (8). First rotation prevention mechanisms (14, 54) that engage with one another are provided on the connector body (10) and the lock nut (50) such that the lock nut (50) does not rotate relative to the connector body (10) when the tube (8) is clamped.

Abstract: A valve assembly (50) comprising a three-way connector (52) operatively interconnecting: an inlet (54) operatively connectable, in use, to an aspirator tube (60), the inlet (54) comprising a first one-way valve (66) permitting, in use, the flow of a fluid from the tube (60) into the three-way connector (52); a first outlet (70) operatively connectable, in use, to a receptacle (63), the first outlet (70) comprising a second one-way valve (67) permitting, in use, the flow of a fluid from the three-way interconnector (52) into the receptacle (63); and a second outlet (90) operatively connectable, in use, to a syringe (96), wherein the receptacle (63) comprises a vent aperture (78) and a porous or perforated element (80) overlying the vent aperture (78).

Abstract: A method of tuning the release of an active agent from a cartridge disposed in a catheter and related cartridges are disclosed herein. In one embodiment, a method of tuning the release of an active agent from a cartridge disposed in a catheter convector is provided. The method can include establishing a desired release profile for an active agent to be delivered into a catheter, and disposing a cartridge having the active agent associated therewith into a fluid pathway of a catheter connector of the catheter. Thus, when an aqueous solution contacts and passes by the cartridge, the active agent is released from the cartridge at the desired release profile.

Abstract: This disclosure relates to methods of reversing blood flow using a blood flow reversal valve that includes a first member having a first passage and a second passage, and a second member having a first passage and a second passage. The first and second members are rotatably fixed relative to one another such that the first passage of the first member is aligned with the first passage of the second member and the second passage of the first member is aligned with the second passage of the second member. A flow directing element is disposed in the cavity and is moveable relative to the first and second members between a first position in which the first passage of the first member and the first passage of the second member are fluidly connected and a second position in which the first passage of the first member and the second passage of the second member are fluidly connected.

Abstract: The invention relates to a valve used in medical procedures. More specifically the invention relates to an introducer sheath valve used in minimally invasive and conventional surgical procedures. The valve may accommodate a wide range of surgical implement diameters, shapes, and multiple implements without imposing the high frictional forces of known valves.

Abstract: A valve comprises a first housing including a first lumen extending therethrough and defining a first disk-facing surface and a second housing including a second lumen extending therethrough and defining a second disk-facing surface, the second housing being mated to the first housing so that the second disk-facing surface faces the first disk-facing surface in combination with a flexible disk gripped between gripping portions of the first and second disk-facing surfaces, the disk including a slit extending therethrough which, when acted upon by a fluid pressure of at least a predetermined threshold level opens to permit fluid flow between the first and second lumens and which, when acted upon by a fluid pressure less than the threshold level remains sealed preventing fluid flow between the first and second lumens and a relief well between opposing portions of the first and second housings radially outside the gripping portions, a width of the relief well exceeding a width of a radially outer portion of the f