Abstract: The present invention discloses a method for measuring a biological stimulus signal, which replaces the conventional wired synchronized signal transmission technology with a wireless synchronized signal transmission technology to increase convenience in usage, and which compensates the delay time of wireless transmission in a calibration way to achieve a synchronization effect, whereby the stimulus signal can be corresponding to the response signal correctly, and whereby the synchronized integrated data of the subject can be correctly generated.

Abstract: An MPI method determines calibration and measurement volumes, wherein the calibration volume is larger than the measurement volume and the overall measurement volume is arranged within the calibration volume. Calibration signals are detected and a system matrix S is created. An MPI measuring signal u is recorded, a location-dependent magnetic particle concentration c with magnetic particle concentration values ci within the calibration volume is reconstructed and the magnetic particle concentration values ci are associated with voxels in the calibration volume. Magnetic particle concentration values ci which were associated with voxels outside of the measurement volume are discarded and an MPI image is generated which exclusively contains magnetic particle concentration values ci which were associated with the voxels within the measurement volume. MPI image data are thereby generated with little artefacts within a short time even in case of high magnetic particle densities outside of the measurement volume.

Abstract: Techniques for measuring ion related metrics at a user's skin surface are disclosed. In one aspect, a method for operating a wearable device may involve determining, based on output of one or more ion selective field effect transistor sensors, various physiological conditions such as a state of hydration, a state of skin health, or the cleanliness of the wearable device or an associated garment.

Abstract: A medical imaging apparatus is designed to acquire medical imaging data of a patient during a medical imaging examination and has a medical data acquisition scanner, which has a patient reception area at least partially enclosed by the scanner, inside of which a body area of a patient for examination is situated during the medical imaging examination. A positioning unit has a projector and at least one positioning surface situated inside the patient reception area. The projector is designed to project at least one item of anatomical information onto the at least one positioning surface inside the patient reception area.

Abstract: The present invention relates to an access gate or gantry—antennas assembly for a therapeutical equipment or for an imaging equipment, particularly for an oncological hyperthermia system. In particular, said assembly comprises an access gate or gantry (2), an array of first antennas (3) coupled with said gantry (2), a bed (4), said bed being at least longitudinally movable with respect to said gantry (2), and at least one second antenna (4A), provided in said bed, where said assembly comprises lifting and lowering means (2A) for lifting and lowering said access gate or gantry.

Abstract: Apparatus, including a magnetic tracking system, which generates a magnetic field near a living subject's body, and a probe, having a distal end that can contact registration points on a surface of the body. The probe has a contact sensor, located within the distal end, that outputs first signals indicative of a quality of the contact between the distal end with the registration points. Located within the distal end is a magnetic detector that outputs second signals that are indicative of respective positions of the registration points in a coordinate frame of the magnetic tracking system. A processor receives a tomographic image of the subject, and verifies, based on the quality of the contact indicated by the first signals, that the registration points are valid, and registers the tomographic image in the coordinate frame of the magnetic tracking system using the positions of the valid registration points.

Abstract: A method and apparatus for determining a three-dimensional orientation of a human head. The method includes first interposing a left and a right anthropological baselines on a patient's face, each anthropological baseline connecting an orbitale point and an auricular point on a corresponding side of the patient's face. A headgear unit having a pair of temple elements and a front housing rotatably attached to the temple elements, where the front housing includes at least two cameras and a 3D compass all movable within the front housing, is then positioned on a patient's head. Each of the two cameras is adjusted such that its view field picks up one of the two anthropological baselines on the patient's face. These view fields of the two cameras are then used to construct a Human Skull Base Plane as a plane formed by the left and right anthropological baselines when these anthropological baselines are parallel and aligned.

Abstract: An objective of the present invention is to provide a sensor device which is used by being attached to a lifeform, and which is capable of easily and reliably carrying out tracking of a deformation of the surface of the lifeform.

Abstract: Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.

Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: Disclosed herein are systems and methods for providing a compressible interconnect for allowing electrical communication between an electronics unit and an analyte sensor in an on-body analyte monitoring device. In other embodiments, systems and methods are provided for reducing the Z-height of an on-body analyte monitoring device by utilizing novel interconnects.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: An imaging agent for detecting analytes in a biological environment includes functionalized, silicon vacancy center-containing nanodiamonds. Individual nanodiamonds of the imaging agent include at least one silicon vacancy center. The at least one silicon vacancy center can emit light having a wavelength in a narrow band in response to illumination having any wavelength in a wide range of wavelengths. The nanodiamonds are functionalized to selectively interact with an analyte of interest. The nanodiamonds can additionally include other color centers, and the imaging agent can include a plurality of sets of nanodiamonds having detectably unique ratios of silicon vacancy centers to other color centers. The silicon vacancy centers in the nanodiamonds can have a preferred orientation enabling orientation tracking of individual nanodiamonds or other applications. A method for detecting properties of the analyte of interest by interacting with the imaging agent is also provided.

Abstract: Provided herein are methods, apparatuses, and non-transitory computer-readable recording media for measuring photoplethysmography (PPG) signals. Accurate PPG signals can be obtained even in a situation in which brightness of ambient light is not constant due to external light sources, and accuracy of a variety of biological information derivable from the PPG signals can be improved.

Abstract: There are provided a method, apparatus and non-transitory computer-readable recording medium for measuring photoplethysmography (PPG) signals. Accurate PPG signals can be obtained even when brightness of ambient light is not constant due to external light sources, and accuracy of a variety of biological information derivable from the PPG signals can be improved.

Abstract: The specification and drawings show an embodiment of the present invention in the form of a device comprising one or more biosensors either placed or imbedded in a catheter, needle or combination of the two. The catheter or needle comprises exclusionary slits upstream of the biosensor(s), angled so that fluid flows in through the slits and down past the biosensors. The wires connecting the biosensors to external monitoring and/or analytical apparatus are wired through the catheter or needle material. Also provided herein are methods for detection of small molecules using the device described herein.

Abstract: An information measuring device includes a detection film placed on the surface of a first needle section, an electrically conductive second needle section, and an electric current detection circuit which detects an electric current between the detection film and the second needle section. The major axis of the first needle section is 0.1 mm or more and 0.3 mm or less.

Abstract: A test strip comprises a test strip body comprising a fluid reservoir. The test strip further comprises a sensor unit configured to determine measurement data of a probe fluid in the fluid reservoir, and a communication unit electrically connected to the sensor unit, the communication unit including an antenna unit configured to transmit the measurement data. A system for determining measurement data of a probe fluid comprises the test strip and an external reader.

Abstract: Bodily fluid sample transport systems, devices, and method are provided. In at least one embodiment described herein, methods are provided for the physical transport of small volumes of bodily fluid in liquid form from one location to another location. By way of nonlimiting example, the samples are collected in liquid form at a collection site, transported in liquid form, and arrive at an analysis site in liquid form. In many embodiments, the liquid form during transport is not held in a porous matrix, wicking material, webbing, or similar material that prevents sample for being extracted in liquid form at the destination site. In one embodiment, small volume of sample in each sample vessel is in the range of about 1 ml to about 1 microliter.

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: A method and system for measuring psychological stress disclosed. In a first aspect, the method comprises determining R-R intervals from an electrocardiogram (ECG) to calculate a standard deviation of the R-R intervals (SDNN) and determining a stress feature (SF) using the SDNN. In response to reaching a threshold, the method includes performing adaptation to update a probability mass function (PMF). The method includes determining a stress level (SL) using the SF and the updated PMF to continuously measure the psychological stress. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.

Abstract: A data driven assessment apparatus and method generates assessment data of an individual's traits. The apparatus and method use a cloud based approach to assessment analysis which provides business administrators and individuals with personality profiles.

Abstract: Methods and apparatus to form a biometric based information communication system are described. In some examples, the biometric based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result. In some examples, the biometric result may relate to a level of fatigue or sleepiness of the user. In some examples, the user may be operating machinery. In some examples the biometric based information communication system may comprise a user device such as a smart phone paired in communication with the biomedical device. A biometric measurement result may trigger a communication of a biometric based information communication message which may be tailor to the user and historical records relating to the user.

Abstract: A method for predicting an arousal level used by a computer of an arousal level prediction apparatus that predicts an arousal level of a user includes obtaining current biological information regarding the user detected by a first sensor, calculating a current arousal level of the user on the basis of the current biological information, obtaining current environment information indicating a current environment around the user detected by a second sensor, predicting a future arousal level, which is an arousal level a certain period of time later, on the basis of the current arousal level and the current environment information, and (i) issuing a notification to the user or (ii) controlling another device, on the basis of the future arousal level.

Abstract: A fluid analysis device including a fluid receipt chamber, a first capacitive element for measuring fluid flow into the fluid receipt chamber and a controller operatively coupled to the first capacitive element, wherein the controller is configured to measure a first capacitance of the first capacitive element.

Abstract: Systems and methods detect a multicomponent brain-based bio-signal in non-brain internal body tissues and cavities of a patient, such as the mouth and nostrils. Sub-component signals are filtered from the multi-component signal to isolate occurrences of physiological activities that correspond to the sub-component signals, such as eye movement, heart function, respiration, and body movement. Based on detections of certain body activities from the sub-component signals, the control of or display of a body monitoring device is influenced by such detections.

Abstract: Vascular conditions are detected non-invasively in the human body using a collection of information from small local regions of the vasculature. An array of accelerometers are attached to the head and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a signature library for further processing. The signature library is used to localize the origin of recognized vascular features and the localized feature is presented to the physician in a clinically relevant manner.

Abstract: The present invention relates to a process without a therapeutic target that evaluates at least one facial clinical sign and/or evaluates make-up, in particular evaluates wrinkles or fme lines from a portion of the face, including steps consisting in:—from a sequence of facial images of a person filmed while emitting at least one sound, extract from the sequence one or more images coinciding with the emission of at least one predefined sound,—from the resulting image or images extracted, evaluate at least one facial clinical sign appearing on the image or images extracted and/or evaluate at least one characteristic related to make-up.

Abstract: A system, an apparatus, and a method for measuring muscle stiffness in a predetermined joint of an individual are provided. The system and apparatus comprises a measuring unit and a processing unit. The measuring unit is configured to be applied to a body segment of the predetermined joint. The processing unit is configured to: receive a plurality of data sets from the at least one measurement device, analyze the plurality of data sets for one or more indications of an elicited stretch reflex, and calculate a muscle stiffness score. The muscle stiffness score is based on at least a difference between a first stiffness and a second stiffness. The first stiffness is determined from the first subset, and the second stiffness is determined from the second subset.

Abstract: A posture of a user is monitored by obtaining first pressure sensor information from a plurality of sensors upon a first item of furniture occupied by the user at a first time. First sensor position information defining the relative positions of the sensors upon the first item of furniture is also obtained. The first pressure sensor information and the first sensor position information are processed to determine a first user posture upon the first item of furniture. User posture is monitored over time and/or upon different items of furniture, and a cumulative load upon the user's spine over time is determined.

Abstract: A method and device for determining respiratory airflow metrics during a single inspiratory breath and using those metrics to calculate indicators of aerobic capacity and athletic endurance as well as a method and device for strengthening the respiratory muscles.

Abstract: Methods and apparatus to form a biometric based information communication system are described. In some examples, the biometric based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result. In some examples the biometric based information communication system may comprise a user device such as a smart phone paired in communication with the biomedical device. A biometric measurement result may trigger a communication of a biometric based information communication message.

Abstract: Methods and apparatus to form a biometric based information communication system are described. In some examples, the biometric based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result. In some examples the biometric based information communication system may comprise a user device such as a smart phone paired in communication with the biomedical device. A biometric measurement result may trigger a communication of a biometric based information communication message. The biometric based information communication message may comprise an advertisement. In some examples, the advertisement may include a means to link to an electronic purchasing or e-procurement vehicle.

Abstract: Methods and apparatus to form a biometric based information communication system are described. In some examples, the biometric based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result. In some examples the biometric based information communication system may comprise a user device such as a smart phone paired in communication with the biomedical device. A biometric measurement result may trigger a communication of a biometric based information communication message.

Abstract: Provided is a method of controlling and adjusting at least one body feature of a subject using electronic mobile devices worked by a person in need thereof and measuring devices interconnected thereto.

Abstract: Provided herein are systems and methods for setting a physiological threshold value in a user interface for a user behavior-modification system; monitoring a physiological parameter corresponding to the physiological threshold value; and notifying the user with a notification when the user exceeds the physiological threshold value. A portion of the user behavior-modification system can be resident in a memory of a first network-connected electronic device configured with a physiological sensor. The physiological sensor can be configured to physiologically couple to the user for monitoring a physiological parameter thereof. Monitoring the physiological parameter can include alerting the user when the user exceeds the physiological threshold value. Notifying the user enables the user to modify behavior to bring the physiological parameter below the physiological threshold value.

Abstract: Apparatus for improving health of a user is provided, including a first sensor, adapted to measure a first physiological variable, which is indicative of a voluntary action of the user. A second sensor is adapted to measure a second physiological variable, which is substantially governed by an autonomic nervous system of the user. Circuitry is adapted to receive respective first and second sensor signals from the first and second sensors, and, responsive thereto, to generate an output signal which directs the user to modify a parameter of the voluntary action.

Abstract: Systems and methods for monitoring hypoxia in a user over a period of time are disclosed. A sensor assembly detects data indicative of at least one physiological parameter of the user and an electronic computing unit analyzes the data indicative of the at least one physiological parameter of the user detected by the sensor assembly and determines, from the analyzed data, an occurrence of a hypoxia event. The electronic computing unit may additionally determine characteristics of the data indicative of the at least one physiological parameter associated with the determined occurrence of the hypoxia event and determine trends from changes in the determined characteristics.

Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.

Abstract: A closed loop, neural activity triggered rehabilitation device and method are provided for facilitating recovery of a patient from the effects of a sensory motor disability. The device includes a sensor system positionable adjacent the brain of the patient. The sensor system detects neural signals. A functional stimulation component is operatively connectable to at least one body part, such as a muscle or a nerve. The functional stimulation component stimulates the at least one body part in response to the neural signals detected. A sensory stimulation module is operatively connected to the patient to provide sensory feedback thereto.

Abstract: A mobile terminal includes: a terminal body forming an outer appearance; a wireless communication unit configured to perform wireless communication with an external device including a first electrode unit installed to be in contact with a part of a user's body; a second electrode unit disposed in a region of the terminal body and brought into contact with the user's body to form a closed sloop with the first electrode unit; and a control unit configured to form a body fat measurement result using a voltage formed by a current flowing between the first and second electrode units.

Abstract: A nerve mapping system includes a plurality of electrodes, a sensor, and a processor in communication with each of the plurality of electrodes and the sensor. Each electrode is disposed on the distal end portion of one or more elongate medical devices configured to extend within an intracorporeal treatment area of a subject. The sensor is in communication with a muscle of a subject, and is configured to provide an output signal corresponding to a monitored response of the muscle. The processor receives an indication of the location of each electrode and an indication of a magnitude of the monitored muscular response. Using these parameters, the processor determines a distance to the nerve from the location of each of the plurality of electrodes, and constructs a virtual model of the nerve using the determined distance to the nerve at each of the plurality of locations.

Abstract: A method of locating a nerve within an intracorporeal space includes advancing a distal end portion of a stimulator toward an anatomical target within the intracorporeal space, and periodically applying a first electrical stimulus from a first electrode disposed on a central axis of the stimulator. If a muscular response to the first electrical stimulus is detected, a locating electrical stimulus is then applied from a plurality of locations offset from the central axis of the stimulator, and a magnitude of the response of the muscle is monitored. A distance between the nerve and each of the plurality of locations is determined from the magnitude of the muscular response, and from a magnitude of the locating electrical stimulus provided at each of the plurality of locations. The location of the nerve is then triangulated from the determined distance at each of the plurality of locations.

Abstract: The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by: a) making an incision in a patient, b) inserting an access device into the patient through the incision to at least partially create a path to a spine of the patient, and c) irradiating nervous tissue adjacent the path with an amount of NIR or red light effective to provide neuroprotection.

Abstract: A biological information detection device includes a case that is provided with a sensor that detects biological information about a subject, a band that secures the case on the subject, and an adjustment mechanism that pulls the band in a first direction when a rotary member that is supported by the case has been rotated, the first direction being a direction in which the side of the case that is situated opposite to the subject comes in contact with the subject.

Abstract: A system for monitoring biosignals of a user includes a first end region, positionable proximate a first ear of a user and including a first sensor array; a second end region, positionable proximate a second ear of the user and including a second sensor array; an intermediate region, positionable on a neck region of the user; a coupling element configured to couple the first and second end regions to the intermediate region; and a first attachment element and a second attachment element. The first attachment element couples the first end region to a head-mounted accessory and the second attachment element couples the second end region to the head-mounted accessory. The first end region includes a first electrode and the second end region includes a second electrode, such that there is a fixed distance between the first and second electrodes.

Abstract: A structure of a detective garment includes a garment body and at least one detection module combined with the garment body. The garment body, when worn on a human body, detects a variation of a physiological signal of the human body or a variation of an inclination angle of the human body. The garment body includes at least one opening section in one side thereof to facilitate wearing of the garment body with one hand.