Abstract: An embedded measurement device that is capable of measuring the component and a composition of a multi-phase flow fluid flowing in a pipe. The embedded measurement device includes: a high-pressure pipe tube in which the multi-phase flow fluid flows; a Raman probe that is partially inserted inside the high-pressure pipe tube and has an optical lens; and a Raman peak analysis unit that is connected to another part of the Raman probe. The device for measuring the composition of the multi-phase flow fluid measures a Raman peak intensity value of the multi-phase flow fluid in the high-pressure pipe tube by using the Raman probe, thereby determining the composition of the fluid.

Abstract: A method of detecting irregular high current flow within an integrated circuit (IC) device is described. The method comprises obtaining infrared (IR) emission information for the IC device, identifying at least one functional component within the IC device comprising a high current flow, based at least partly on the obtained IR emission information, obtaining IR emission information for at least one reference component within the IC device, and determining whether the high current flow of the at least one functional component comprises an irregular high current flow based at least partly on a comparison of respective IR emission information for the at least one functional component and the at least one reference component.

Abstract: Disclosed herein is a quantitative analysis method for measuring a target element in a specimen using laser-induced plasma spectrum. More particularly, the present invention relates to a method for analyzing a composition ratio of a target element by calculating peak intensities when peaks overlap each other in a spectrum, and a method for selecting a peak of a wavelength at which the highest precision and reproducibility are secured through linearity of a correlation plot of the peak intensities and a value by dividing a standard deviation value of calibration curve data (peak intensity ratios) by a slope when an internal standard method is used for quantitative analysis of a target element.

Abstract: The objective of the present invention is to reduce the dispersion of a powdered substance, which is the target substance, during the analysis period in an analyzing device that analyzes the target substance by analyzing the light originated from the substance which is in the plasma state. The present invention relates to an analyzing device including a plasma generation means which generates plasma in the space and maintains plasma using the energy of EM radiation emitted from a radiation antenna; and an optical analysis means which analyzes a target substance by analyzing the plasma light generated from target substance of plasma state in the plasma area during the plasma maintenance period where the plasma is maintained by the plasma generation means using the energy of EM radiation. The plasma generation means emits the EM radiation from the radiation antenna in continuous waves during the plasma maintenance period.

Abstract: A sample analyzer has an illuminator for illuminating an assay sample to cause luminescence, and a support for a sample vessel containing the assay sample. The support is adapted to position the assay sample proximate the illuminator. A detector is positioned along an optical axis extending from the illuminator, through the positioned assay sample, to the detector, so as to detect the luminescence from the assay sample. A reflector is removably disposed between the illuminator and the assay sample so as to reflect a portion of the luminescence back through the positioned assay sample toward the detector.

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

Abstract: Inspection with multiple illumination regions includes generating a primary beam of illumination directed along a primary illumination direction, transmitting a portion of the primary beam of illumination along a first illumination direction, deflecting a portion of the primary beam of illumination along a second illumination direction different from the first illumination direction with one or more angular selection elements, focusing the transmitted portion of the primary beam of illumination onto a first inspection region of the substrate, and focusing the deflected portion of the primary beam of illumination onto a second inspection region of the substrate being spatially separated from the first inspection region.

Abstract: A multispectral imaging system and method and a system for composite layup are provided in order to detect foreign object debris during the fabrication of a composite structure. In the context of a method, a surface of a composite material is illuminated with near infrared light. The method also detects the near infrared light following interaction of the near infrared light with the composite material. Following detection, the method analyzes a spectrum of the near infrared light to detect foreign object debris upon the composite material. The method analyzes the spectrum of near infrared light by distinguishing between different types of foreign object debris as a result of comparing the spectrum of near infrared light to predefined spectral signatures of a plurality of different types of foreign object debris. The method may also determine the size and location of the foreign object debris.

Abstract: A defect inspection device inspecting a sample includes a movable table on which the sample as an inspection object and a pattern chip are mounted, an illumination light irradiation unit which irradiates a surface of the sample or a surface of the pattern chip with linearly-formed illumination light, a detection optical system section where a plurality of detection optical systems are disposed at a plurality of positions above the table and which detect images of scattered light generated from the sample, and a signal processing unit which processes detected signals to detect a defect of the sample surface, and a plurality of repeating patterns for generating the scattered light according to positions of the objective lenses of the plurality of detection optical systems of the detection optical system section when the linearly-formed illumination light is irradiated by the illumination light irradiation unit are periodically formed in the pattern chip.

Abstract: In an X-ray inspecting apparatus, a rotational fluctuation amount of a stage is calculated around a power transmission part of the stage and a stage drive unit as a base point, i.e., the X-axis and Y-axis sliding parts, in accordance with detected positional information from a position detecting sensor. Then, a stage shift amount is calculated in accordance with the rotational fluctuation amount and a distance between the base point and an imaging position on the stage. Here, the stage shift amount corresponds to a positional deviation of the stage at the imaging position caused by an attitude variation of the stage in a yawing direction, and thus is an error in repeated positioning. Accordingly, a tomographic image with high resolution can be generated in consideration of the error in repeated positioning.

Abstract: Apparatus, including a sample-support that retains a sample in a plane having an axis, the plane defining first and second regions separated by the plane. A source-mount in the first region rotates about the axis, and an X-ray source on the source-mount directs first and second incident beams of X-rays to impinge on the sample at first and second angles along beam axes that are orthogonal to the axis. A detector-mount in the second region moves in a plane orthogonal to the axis and an X-ray detector on the detector-mount receives first and second diffracted beams of X-rays transmitted through the sample in response to the first and second incident beams, and outputs first and second signals, respectively, in response to the received first and second diffracted beams. A processor analyzes the first and the second signals so as to determine a profile of a surface of the sample.

Abstract: An improved Pirani sensor uses a measuring element disposed within a fluid between a base plate and a cover. The measuring element is held by suspension members that are connected to the base plate. A heating element is thermally conductively connected to the suspension members. Using the sensor the characteristic of the fluid is determined by evaluating the heat transfer from the thermal element through the fluid into the cover when heating power is applied to measuring element. Parasitic conductive heat loss from the measuring element into the suspension members is compensated by applying power to the heating element.

Abstract: A first bridge fixed resistor (211) of a combustible gas detection apparatus (1) is composed of a resistor element which is less likely to deteriorate as compared with a second bridge fixed resistor (212) and a variable resistor section (213). The combustible gas detection apparatus (1) can judge a deteriorated state of at least one of the second bridge fixed resistor (212) and the variable resistor section (213) on the basis of the absolute value of a difference temperature ?T which is the difference between a detection-time judgment temperature T1 and a reference judgment temperature T0. The combustible gas detection apparatus (1) obtains a corrected high-temperature-time voltage VH? and a corrected low-temperature-time voltage VL? through use of a voltage error ?V1. Thus, a decrease in the accuracy in detecting the hydrogen concentration can be suppressed even when the resistance of the resistor section changes.

Abstract: The present invention is directed to a process for evaluating corrosion resistance of coated metals substrates, such as autobodies at accelerated rate. An anode and cathode coated with protective coating being tested are exposed to an electrolyte in a chamber of a corrosion resistance evaluator. These coatings are provided with predetermined and standardized defects, such as micro-holes to accelerate the corrosion of the underlying metal substrate in a predictable and repeatable manner. The coated cathode/anode pair is subject to a start-up period followed by series preset DC voltages modulated in a stepwise manner for preset durations that are interspaced with recovery periods. The impedance data collected are then used to arrive at the corrosion performance resistance of the coating applied over the cathode/anode pair. The foregoing evaluator substantially reduces the time required to test corrosion from several days (40 plus days) to few days (about two days).

Abstract: A foam sensor system includes a flexible bag comprised of a polymeric material and bounding a compartment. A foam sensor assembly is mounted on the flexible bag and includes a foam contact disposed within the compartment of the flexible bag. A ground assembly is mounted on the flexible bag and includes a ground contact disposed within the compartment of the flexible bag, the foam sensor assembly and the ground assembly being configured so that an electrical potential can be applied between the foam contact and the ground contact.

Abstract: A sensor for sensing gaseous chemicals includes a substrate, a variable resistance nanocrystalline ITO thin film formed on the substrate, and electrodes electrically coupled to the thin film. A sensor array assembly includes a sensor slide and a perforated interface circuit. The interface circuit abuts and electrically couples the sensor slide. The sensor slide includes several spaced apart ITO film strips formed on a slide substrate. A common electrode is electrically coupled to a common portion of each ITO film strip providing an electrically conductive path across the common portions of each of the plurality of spaced apart ITO film strips. A discrete electrode is electrically coupled to a discrete portion of each ITO film strip. The interface circuit is configured to abut and electrically couple to the sensor slide. A conductive discrete electrode pad electrically couples each of the plurality of discrete electrodes of the sensor slide to discrete terminals on the interface circuit.

Abstract: Disclosed is an integrated circuit comprising a substrate (10) carrying plurality of circuit elements (20); a plurality of sensing electrodes (34) over said substrate, each sensing electrode being electrically connected to at least one of said circuit elements; and a plurality of wells (50) for receiving a sample, each sensing electrode defining the bottom of one of said wells, wherein each sensing electrode comprises at least one portion (34?) extending upwardly into said well. A method of manufacturing such an IC is also disclosed.

Abstract: A non-enzymatic glucose sensor and method for fabricating the sensor are disclosed. The glucose sensor contains at least one non-enzymatic electrode configured to catalyze the electro-oxidation of glucose in preference to other bio-molecules. The surface of the electrode comprises CuO nanoparticles. The sensor shows sensitivity and selectivity exceeding enzyme based devices presently in use.

Abstract: A bio-sensing semiconductor structure is provided. A transistor includes a channel region and a gate underlying the channel region. A first dielectric layer overlies the transistor. A first opening extends through the first dielectric layer to expose the channel region. A bio-sensing layer lines the first opening and covers an upper surface of the channel region. A second dielectric layer lines the first opening over the bio-sensing layer. A second opening within the first opening extends to the bio-sensing layer, through a region of the second dielectric layer overlying the channel region. A method for manufacturing the bio-sensing semiconductor structure is also provided.

Abstract: Methods that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer.

Abstract: The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.

Abstract: A method of locating metal or non-metal containing objects and materials includes regulating currents in at least two emission coils in relation to each other. A reception coil output signal is received by at least one reception coil or average values of demodulation phases generated from the reception coil output signal are regulated in relation to each other continuously to be zero even when exposed to metal. The amplitude(s) of the required controlled variables are detected as a value by demodulation, preferably at least at 0° and at a demodulation which is set off by 90° and are equalized, thereby allowing a reliable detection of an object to be detected even if other metal objects are present in the area of detection.

Abstract: A building structure includes a block of building material and a magnetic circuit buried in the block of building material. The structure also includes a plurality of sensing devices buried in the block of building material. Each sensing device may include a contactless power supplying circuit magnetically coupled with the magnetic circuit to generate a supply voltage when the magnetic circuit is subject to a variable magnetic field.

Abstract: An apparatus for manipulating particles within a fluid sample includes a substrate having a substrate surface. A surface acoustic wave (SAW) generator generates a SAW within a SAW region of the substrate surface. The SAW has an SAW direction aligned with a pressure node. A channel is configured to receive the fluid sample and the fluid sample has a flow direction which is at an oblique angle to the SAW direction.

Abstract: An ultrasonic near-surface inundation testing (UNIT) device includes a soil cell device, a head tank feeding fluid into the soil cell and a reservoir tank feeding fluid into the head tank. The soil cell device includes a substantially planar base, at least one removable top plate with at least one pressure equalization port, at least one bottom plate, at least one sample chamber holding a soil sample, bender ports and a bender sensor pair. The base connects to chamber posts. The top plate connects to the chamber posts and has a cell inlet receiving fluid from the head tank. The bottom plate connects to the chamber posts and has a cell outlet passing fluid to the reservoir tank. The sample chamber, including at least one removable chamber plate, is located between the top and bottom plates. The bender sensor pair extend into the sample chamber through the bender ports.

Abstract: Components resolved in time by a separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques. The sample cell can be configured for multiple path absorption and can be heated. The separator can be a gas chromatograph or another suitable device, for example a distillation-based separator. The method and system described herein can include other mechanical elements, controls, procedures for handling background and sample data, protocols for species identification and/or quantification, automation, computer interfaces, algorithms, software or other features.

Abstract: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.

Abstract: To efficiently heat and burn a sample without using a combustion aid, an analysis device that heats a sample in a sample accommodation part and analyzes the resulting gas is provided with an induced current generation mechanism for generating an induced current in the sample through electromagnetic induction and a laser irradiation mechanism for irradiating laser light onto the sample and is configured so that the induced current generation mechanism and the laser irradiation mechanism act simultaneously on the sample.

Abstract: Embodiments of the invention relate to methods of modeling leaching behavior of a polycrystalline diamond (“PCD”) material used in leached polycrystalline diamond compacts (“PDCs”) and methods of monitoring leaching of a PCD material. In an embodiment, a method of modeling leaching behavior is disclosed. A PCD table is provided, which includes a plurality of bonded diamond grains defining a plurality of interstitial regions in which a metallic material is disposed. The PCD table is leached with a leaching agent to at least partially remove the metallic material from the PCD table. A leach depth of the PCD table is determined. A concentration of at least one constituent of the leaching agent is also determined. The leach depth is correlated with the concentration of the at least one metal to generate the model of leaching behavior.

Abstract: Systems and methods for diagnosing a sensor for an exhaust system may include perturbing an output signal from the sensor for the exhaust system. The method may further include monitoring an output signal from a controller for controlling a component affecting the exhaust system or an unperturbed output signal from the sensor and diagnosing the sensor based on the monitored output signal from the controller or the unperturbed output signal from the sensor. In another implementation, a first controller may output the output signal from the sensor to a second controller configured to have a predetermined response to output signal. The first controller receives a response from the second controller and diagnoses the sensor based on the received response.

Abstract: A system and method for cavity ring-down spectroscopy can include a pulsed quantum cascade laser, an optical ring-down cavity, a photodetector, and an oscilloscope. The system and method can produce pulse widths of less than 200 ns with bandwidths greater than 300 pm, as well as provide temporal resolution of greater than 10 ?s.

Abstract: A portable electronic device and a related methods are described using an integrated chemical sensor linked to a chemical sensor processing unit and being sensitive to the concentration of a component in a sample of air and one or more contextual sensors not including chemical, temperature and humidity sensors, wherein output from the contextual sensors is linked to a local or remote interpretation processor generating a constraint or correlation set transferred to the chemical sensor processing unit for use in determining a result of a chemical measurement as performed by the chemical sensor.

Abstract: Disclosed herein are a method of manufacturing large area graphene nanoribbons, which have no residual layer by interposing a chromium layer between a resist layer and a graphene layer, and a sensor including the graphene nanoribbons.

Abstract: This invention relates to a method and an apparatus for characterizing eggshells of eggs, the eggs being supported, comprising: —deforming the eggshell, —scanning the eggshell with a laser beam of a Self Mixing Laser Vibrometer (SMLV) with scanning signals, whereby a reflection light signal of reflection light is obtained, —processing scanning signal and the reflection signal with the SMLV, whereby a mixed signal with crack information is obtained, —during scanning moving the eggs relative to the SMLV, —comparing the signals with preset criteria and characteristics of such eggs, whereby comparative data are obtained, and —characterizing the eggshells on the basis of the comparative data.

Abstract: A pressure probe for detecting clathrates includes a probe wall defining an inside area. A window is arranged in the probe wall. A device including a circuit board having a surface is arranged below the window. A permittivity sensor and temperature sensor are arranged on the surface of the circuit board and in thermal contact with each other and with a temperature control device. An insulating layer is disposed on the surface of the circuit board over the permittivity sensor and the temperature sensor. The window includes a part of the insulating layer.

Abstract: A moisture content indicator for visually indicating the moisture content of a wood substrate and methods of making the moisture content indicator are provided.

Abstract: Device for spermatozoa selection comprising a first chamber configured to receive a first, seminal fluid; a second chamber configured to receive a second fluid, the second chamber being in fluid communication with the first chamber by means of at least one duct having a first opening to the first chamber and a second opening to the second chamber; and a displacement means adapted to displace at least some of the first, seminal fluid towards the first opening.

Abstract: Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity are disclosed. In particular, the invention relates to engineered protein voltage sensors that comprise a voltage-sensing domain comprising four transmembrane domains linked to a circularly permuted fluorescent protein, which is inserted into the extracellular loop between the third (S3) and fourth (S4) transmembrane segments of the voltage-sensing domain. Such fluorescent protein voltage sensors can be used for measuring the electrical activity of neurons, including single action potentials, trains of action potentials, and subthreshold potential changes and, in particular, for imaging high-frequency neuronal electrical activity.

Abstract: A method of analyzing a biological sample, for example serum or other blood-based samples, using a MALDI-TOF mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a MALDI-TOF sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument. In some embodiments at least 100,000 laser shots and even 500,000 shots are directed onto the sample. It has been discovered that this approach, referred to as “deep-MALDI”, leads to a reduction in the noise level in the mass spectra and that a significant amount of additional spectral information can be obtained from the sample. Moreover, peaks visible at lower number of shots become better defined and allow for more reliable comparisons between samples.

Abstract: A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.

Abstract: An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position.

Abstract: An automated platelet function analyzer includes a sampling vessel, a preparation vessel, an analysis vessel, a sampling needle, an analysis solution syringe, a detergent syringe, and blood mixing devices. The sampling vessel is placed in a sample holder, which vacillates left and right. A method for platelet analysis is also disclosed.

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

Abstract: Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading cells with labeled substrate (e.g. labeled by 13C, 15N, or 31P). The methods allow for easy identification of metabolites that are differentially generated in cells of different phenotypes. The new methods for unbiased multi-dimensional NMR screening and rapid and efficient analysis of the NMR screening identify differentially expressed metabolites in different cell or tissue types. Analysis of the differentially expressed metabolites can present unique druggable targets to which small molecule therapeutics can be designed.

Abstract: The invention features a method of identifying a therapeutically active compound that inhibits apoptotic compensatory signaling complex (ACSC)-induced cell proliferation.

Abstract: A platform for biological assays includes a base substrate providing structural support to the platform, at least one surface of the base substrate coated with position markers, a first deformable layer positioned on top of the base substrate, and a second deformable layer positioned on top of the first deformable layer, the second deformable layer embedded with deformation markers.

Abstract: The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.

Abstract: Described herein are devices and methods for identifying the existence of an oral condition in a subject.

Abstract: Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e. haloalkane) that reacts with tryptophan residues to form fluorescent products. Irradiation of the samples with ultraviolet light and the detection and quantification of the resultant fluorescent emissions from all proteins in each sample are then used to obtain comparative values for total protein content among the various samples.

Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.