Abstract: The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.

Abstract: Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.

Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.

Abstract: The present invention relates to novel antigen binding proteins, in particular monoclonal antibodies, capable of binding to the protein Axl as well as the amino and nucleic acid sequences coding for said proteins. From one aspect, the invention relates to novel antigen binding proteins, or antigen binding fragments, capable of binding to Axl and, by inducing internalization of Axl, being internalized into the cell. The invention also comprises the use of said antigen binding proteins as addressing products in conjugation with other anti-cancer compounds, such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers.

Abstract: This invention relates to monospecific and multispecific antibodies that may be utilized for the diagnosis and treatment of various diseases. In addition, these antibodies may be modified by protease cleavage. Protease control or regulation may be provided by a protease site located in, for example, a linker. These protease-regulated antibodies may also be utilized for the diagnosis and treatment of various diseases.

Abstract: A bispecific antibody format devoid of an active Fc moiety comprising a monovalent binding site for a death receptor and at least one binding site for a cell surface antigen expressed on B-cells, for use in the treatment or prevention of B cell mediated autoimmune diseases.

Abstract: Embodiments of the invention provide regioselectively substituted carbohydrate and polysaccharide derivatives, such as cellulose esters, and methods for preparing them. Particular methods of the invention include deacylation of esters using tetrabutylammonium fluoride to obtain selective substitution at desired hydroxyl position(s) of the ester. Preferred is deacylation of an ester, which shows selectivity for removal of acyl groups from the ester of the secondary alcohols at C-2 and C-3, and which affords cellulose-6-O-esters with high regioselectivity by a simple one-step process employing no protective groups. Inventive regioselectively substituted cellulose esters can be prepared by such methods to obtain esters with the following anhydroglucose repeating units: wherein R1, R2, and R3 are each independently chosen from a hydrogen atom, and, whether substituted or unsubstituted, branched or unbranched, an alkanoyl group, an aroyl group, and a heteroaroyl group.

Abstract: In accordance with some embodiments of the present invention, a composite material is prepared by blending a flame retardant modified cellulosic nanomaterial (FR-CN) filler into a polymer, wherein the FR-CN filler comprises a cellulosic nanomaterial (e.g., cellulose nanocrystals (CNCs) and/or cellulose nanofibrils (CNFs)) having a surface functionalized to incorporate a phosphorus-containing moiety. In some embodiments, the FR-CN filler is prepared by reacting hydroxyl groups on the surface of the cellulosic nanomaterial and a halogenated phosphorous-containing monomer (e.g., diphenyl phosphoryl chloride). In some embodiments, the surface of the cellulosic nanomaterial is further functionalized to incorporate an orthogonal functionality selected to enhance the compatibility of the FR-CN filler with the polymer by reacting hydroxyl groups on the surface of the cellulosic nanomaterial and a monomer (e.g., epichlorohydrin when the polymer is an epoxy-based polymer).

Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).

Abstract: A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P-CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance.

Abstract: The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.

Abstract: A system and method for a polyolefin reactor temperature control system having a first reactor temperature control path, a second reactor temperature control path, and a shared temperature control path. The shared temperature control path is configured to combine and process coolant return streams, and to provide coolant supply for the first reactor temperature control path and the second reactor temperature control path.

Abstract: A macromolecular emulsifier with switchable surface activity, and use thereof for preparation of polymer latex is disclosed. By using the macromolecular emulsifier with switchable surface activity as an emulsifier, a reversibly coagulable and re-dispersible polymer latex can be prepared by emulsion polymerization. The polymer latex can achieve the coagulation of latex particles by heating and aerating with nitrogen, air, inert gas and/or adding a small amount of alkali solution; the coagulated latex particles can be restored and re-dispersed into stable latex by aerating with carbon dioxide and/or adding a small amount of acid solution. The coagulation and re-dispersion process is reversible and is easy to control.

Abstract: The invention relates to matted UV varnishes comprising silicon dioxide, the surface thereof having been modified by means of treatment with a multiple bond organopolysiloxane so as to be particularly well-suited for use as a matting material for UV varnishes, and to a method for producing same.

Abstract: To provide a terminal group conversion method and a terminal stabilizing method, which are capable of converting unstable terminal groups in a fluorinated polymer to carboxylic acid fluoride groups at a high conversion rate. A fluorinated polymer is heated at from 200 to 400° C. for at least one hour in the presence of at least 50 mol of molecular oxygen per 1 mol of unstable terminal groups in the fluorinated polymer, to convert from 50 to 100 mol % of the unstable terminal groups to carboxylic acid fluoride groups.

Abstract: Functionalization of polymers, including polyolefins, with a, ?-unsaturated carboxy-derived moieties through the use of solid-state shear pulverization.

Abstract: A process of forming a Ziegler-Natta catalyst component is disclosed. The process includes contacting an alkyl magnesium compound with an alcohol and a first organoaluminum compound to form a magnesium dialkoxide compound and contacting the magnesium dialkoxide compound with a titanating agent to form reaction product “A.” The process further includes reacting reaction product “A” with a halogenating agent to form reaction product “B” and reacting reaction product “B” with a second organoaluminum compound to form a single halogenated catalyst component.

Abstract: A method for producing a water absorbent resin, the method including a polymerization step, a drying step, a classification step, and a surface crosslinking step. The classification step carried out before or after the surface crosslinking step requires use of a tapping material and a metal sieve mesh, in which the tapping material being heated at 40° C. to 100° C. is installed below the metal sieve mesh, and the metal sieve mesh has an area of 1 to 10 m2/sheet. The classification step further requires introducing a classification aid particle, which has a specific gravity different from that of the water absorbent resin, to the metal sieve mesh; and monitoring the presence or absence of damage to the metal sieve mesh.

Abstract: The present disclosure provides a process. In an embodiment, the process includes producing a propylene-based polymer in a gas-phase polymerization reactor (10) under polymerization conditions. The polymerization conditions include a combined propylene-plus-propane partial pressure from 290 psia to 450 psia. The process further includes maintaining the combined propylene-plus-propane partial pressure in the range from 290 psia to 450 psia while simultaneously: (i) reducing propylene partial pressure in the gas-phase polymerization reactor; (ii) adding propane to the gas-phase polymerization reactor; (iii) introducing at least one C4-C10 comonomer into the gas-phase polymerization reactor (26); and forming a propylene/C4-C10 interpolymer in the gas-phase polymerization reactor (44).

Abstract: The present invention relates to a new metal complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R5 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R5 may be linked to each other to form a ring; R6-R9 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 arylox

Abstract: The present invention is directed to partially fluorinated copolymers and the production thereof. More specifically, the copolymers, which are preferably produced by a solution polymerization process, preferably have at least three units, the first unit selected from 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene, the second unit having a polymerized monomer selected from the vinyl esters and vinyl ethers, and the third unit having a polymerized monomer derived from a hydroxyl group-containing vinyl ether. The resulting copolymer is environmentally friendly, has favorable molecular weight characteristics, and may be shipped economically in high concentration.

Abstract: Purpose: To provide a melt-moldable tetrafluoroethylene/perfluoro(alkyl vinyl ether) copolymer with excellent durability without causing an excessive decrease of the melt flow rate and an increase of the perfluoro(alkyl vinyl ether) content. Solution means: A melt-moldable tetrafluoroethylene/perfluoro(alkyl vinyl ether) copolymer, which is characterized in that in a parallel plate mode of a dynamic viscoelasticity measuring device, when the temperature is raised from ?40° C. to 200° C. at 5° C./min while fixing the measuring frequency to 1 Hz, the slope (? tan ?/?T) of the loss tangent (tan ?) measured between two arbitrary points in a range of 50-75° C. and at a temperature difference of 3° C. or higher is always in a range of 0.0005-0.0030, and its preparation method.

Abstract: A method for producing a (meth)acrylic resin composition, the method comprises the steps of continuously feeding methyl methacrylate and the other materials into a tank reactor while controlling each of the amounts thereof, performing bulk polymerization in the tank reactor to obtain a reaction product, recovering a mixture (A) containing methyl methacrylate and the others from the reaction product, and continuously feeding the mixture (A) into the tank reactor, wherein each of the amounts of methyl methacrylate and the others being fed into the tank reactor are controlled on the basis of the amount of the mixture (A) being fed into the tank reactor and the proportions of methyl methacrylate and the others in the mixture (A), and the perfect-mixing time of the tank reactor, the half life of a radical polymerization initiator at a temperature equal to the temperature inside the tank reactor, the agitation power of the tank reactor, the mean residence time of a reaction starting material in the tank reactor, an

Abstract: The present invention relates to a superabsorbent polymer which has excellent initial absorbency and keeps water from flowing out under pressure even after passage of time. The superabsorbent polymer of the present invention is characterized by simultaneously optimizing centrifuge retention capacity (CRC), absorbency under pressure (AUP), liquid permeability (SFC), and gel strength within a predetermined range. The present invention can provide improved physical properties of a final diaper product and apply an ultra-thin technology to the diaper product.

Abstract: A process for producing a fluorinated copolymer includes polymerizing a fluorinated monomer having a carboxylic acid functional group or a sulfonic acid functional group and a fluorinated olefin by a solution polymerization method in a polymerization medium to obtain a mixture containing a fluorinated copolymer, an unreacted monomer and the polymerization medium. The mixture is continuously or intermittently transferred to an evaporation vessel provided with a stirrer and heating the mixture with stirring in the evaporation vessel to evaporate and recover the unreacted monomer and the polymerization medium.

Abstract: The disclosure relates to a novel process for functionalizing NCC, a method for producing amine-cured epoxy-based nanocomposites through the use of said functionalized NCC, and nanocomposites thereof. The process for functionalizating NCC comprises providing a mixture of NCC and one or more monomers. The mixture is suitable for free radical polymerization and the monomer is cross-linkable with epoxy and is aqueous soluble. The polymerization takes place in the presence of a free radical initiator and oxygen is purged from the mixture and the initiator solution. The epoxy-based nanocomposite is produced by mixing the funtionalized NCC with an amine-curable epoxy resin and a hardener, in a solvent, and allowing the mixture to cure.

Abstract: The mixture of the invention contains, for 100 parts by weight: (A) 10 to 90 parts in weight of at least one copolymer grafted to polyamide blocks, said copolymer comprising a polyolefin trunk and at least 1.

Abstract: Disclosed is a graft monomer composition for thermoplastic transparent resins, a composition for thermoplastic transparent resins using the same and a thermoplastic transparent resin that exhibits superior transparency and color at low rubber contents. According to the graft monomer composition, the composition for thermoplastic transparent resins and the thermoplastic transparent resin, although the content of rubber in final products increases or the content of rubber in graft copolymers in the preparation of final products increases, the copolymer surrounds the surface of rubber well, thus reducing haze, considerably improving transparency and exhibiting excellent natural color.

Abstract: The invention relates to thermoplastic molding materials based on acrylonitrile-butadiene-styrene, comprising a SAN-polymer matrix and a graft copolymer, structured from an agglomerated rubber-graft base and a SAN-graft envelope. The basis of the graft base is a diene rubber having a vinyl-aromatic ratio of 10.5 to 24.5 wt %. The agglomerated graft base has a bimodal particle size distribution of a fraction x) of non-agglomerated particles having a d50-value in the range from 80 to 120 nm and a fraction y) of agglomerated particles having a d50-value in the range of 350 to 550 nm and a polydispersity U of less than 0.28. The invention further relates to a method for producing the graft copolymer, wherein an acrylate copolymer having a polydispersity U of less than 0.27 and a d50-value of 100 to 150 nm is used for agglomeration. The invention further relates to the use of thermoplastic molding materials for producing molded parts.

Abstract: In various embodiments, provided are hydrophilically-modified silicone compositions comprising substantially spherical elastomeric microparticles, methods of making such compositions, and silicone pastes, personal care, and healthcare products comprising such silicone compositions.

Abstract: The method of preparing a functionalizable monolithic platform includes the steps of: functionalizing the silanol groups on a support having silanol groups or the ketone groups on a support having ketone groups with an organic compound having a vinyl group; and copolymerizing the alkenyl-functionalized silanol or ketone groups with itaconic anhydride monomers and vinyl monomers and/or a crosslinker having at least two vinyl reactive groups in a solvent by adding a suitable initiator for a time and temperature or radiation energy sufficient to thereby complete the copolymerization reaction process. The functionalizable monolithic platform has the structural formula: wherein n, m, n? and m? are integers greater than 0.

Abstract: The present invention relates to a polyurethane foam obtained from a polyurethane raw material containing polyol, isocyanate, a foam stabilizer, a catalyst and a foam-forming gas by a mechanical froth method, wherein the polyol contains a castor oil-based polyol having a viscosity at 25° C. of 2,000 mPa·s or less, and a polyether-based polyol, the castor oil-based polyol is contained in an amount of from 20 to 80 parts by weight per 100 parts by weight of the polyol, the polyether-based polyol is contained in an amount of from 20 to 80 parts by weight per 100 parts by weight of the polyol, the polyurethane foam has an apparent density of from 100 to 700 kg/m3, and compressive residual strain at 100° C. of 20% or less, and the polyurethane foam can be preferably used as a sealing material in a neighboring region of a heat source.

Abstract: A one-component type curable composition includes: an isocyanate group-containing urethane prepolymer (A) obtained by allowing a polyoxyalkylene-based polyol (a-1) having a number average molecular weight of 1,000 or more and less than 3,000, a polyol (a-2) having a number average molecular weight of less than 1,000, an epoxy (meth)acrylate (a-3) containing two or more hydroxyl groups in one molecule, and isophorone diisocyanate (a-4) to react with each other; a compound (B) having an oxazolidine ring; a first curing accelerator (C) configured to accelerate a reaction between at least one of a secondary amino group or a hydroxyl group generated by hydrolysis of the (B) and an isocyanate group of the (A); and a second curing accelerator (D) configured to accelerate the hydrolysis of the (B).

Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/Dansyl) post-polymerization.

Abstract: The invention relates to a polyester resin which is based on at least one fatty acid, with a zero oil length (0%) or an oil length of between 0 and 35%, with a weight ratio of oxidizable fatty acids (monoacids), relative to the overall fatty acids, of 0 or greater than 0 and ranging up to 1, and which is based on an acid component comprising, in addition to said fatty acid, from 30% to 85% by weight, relative to the total weight of said resin, of rosin and/or of derivatives thereof bearing at least one carboxylic acid function.

Abstract: A biorenewable thermoplastic, poly(dihydroferulic acid) (PHFA), which is an effective polyethylene terephthalate (PET) mimic is disclosed. The PHFA can be prepared by the self-condensation of acetyldihydroferulic acid as the monomer that can be synthesized from the starting material-ferulic acid, which can be isolated from lignin, rice bran, or other biorenewable sources.

Abstract: A polymer comprises reaction product of (a) one or more diacid, diester thereof, glycolide, and (b) one or more polyol, wherein component (a) comprises glycolide or combinations thereof, and component (b) comprises one or more polyol comprising a mixture of 1,3-cyclohexanedimethanol and 1,4-cyclohexanedimethanol, or 2,2,4,4-tetramethyl-1,3-cyclobutanediol, or combinations thereof.

Abstract: Medium and high molecular weight polyester polymers are prepared in syrup form from an ester oligomer. The oligomer is converted to the polymer by polycondensation at elevated pressure and elevated temperature in a nonreactive carrier capable of forming an azeotrope with water. The ester oligomerization or polycondensation reactions desirably are monitored using a non-viscometric technique. The process has a rapid cycle time. The syrup contains the polymer and nonreactive carrier, and may more conveniently be used to make initially non-solid products such as polyester coatings than is the case when employing pelletized solid polyester resins.

Abstract: The present invention concerns a catalyst formulation comprising: (a) a Zn catalyst comprising a Zn compound having alcoholate ligand(s) derived from one or more polyols, and (b) a catalyst additive comprising a metal compound (i) having alcoholate ligand(s) derived from one or monohydric alcohol wherein the metal is selected from: (I) group 2 metals, preferably Mg, Ca, Sr, and Ba, more preferably Mg, (II) Li, and (III) combinations of at least two metals selected from (I) and (II). The present invention also relates to a process for polymerizing an epoxide monomer, preferably ethylene oxide, comprising carrying out the process in the presence of the catalyst formulation.

Abstract: Condensation of fluoro-substituted and silyl-substituted monomers provides polymers suitable for use, e.g., as engineering polymers. A monomer composition is condensed in the presence of a basic catalyst. The monomer composition contains a compound of formula F—X—F and a compound of formula (R1)3Si—Z—Si(R1)3, and forms an alternating X—Z polymer chain and a silyl fluoride byproduct. X has the formula -A(-R2-A)n-; each A is SO2, C(?O) or Het; R2 is an organic moiety; n is 0 or 1; Het is an aromatic nitrogen heterocycle; Z has the formula -L-R3-L-; each L is O, S, or N(R4); and each R3 is an organic moiety, and R4 comprises H or an organic moiety.

Abstract: Provided are a curable composition and its use. The curable composition exhibits excellent processability and workability before curing, and excellent light extraction efficiency, hardness, thermal and shock resistance, moisture resistance, gas permeability, and adhesiveness after curing. In addition, the curable composition may provide a cured product that exhibits long-lasting durability and reliability even under harsh conditions, and does not causing whitening and surface stickiness.

Abstract: A resin composition, which can achieve the crystallization effect of pentaerythritol, is provided with good workability. The resin composition includes a thermoplastic resin (A) and pentaerythritol particles (B), wherein 70% or more of the pentaerythritol particles (B) have a particle diameter of 100 ?m or less.

Abstract: The present invention provides the resin composition having excellent inflation moldability by which a film having high water vapor transmission rate (WVTR) and low elastic modulus can be produced, and a film which is formed from the resin composition. The present invention relates to a resin composition comprising a polyamide resin (A) and a polyvinyl alcohol-based resin (B) which includes 2-10% by mole of structural unit represented by the following general formula (1) and has a degree of saponification of 70-90% by mole, and a film which is formed from the resin composition. [In the formula, R1 to R6 each independently represent a hydrogen atom or an organic group, and X represents a single bond or a linking chain.

Abstract: A formulation includes a polymeric material, a nucleating agent, a blowing, and a surface active agent. The formulation can be used to form a container.

Abstract: A polyolefin microporous membrane is produced by forming a gel-like molding using a polyolefin resin containing polypropylene, and stretching the molding in at least one direction, followed by washing, the polyolefin microporous membrane having an injection of electrolyte of 20 seconds or less and a uniform polypropylene distribution in at least one plane perpendicular to the thickness direction.

Abstract: An asymmetric tape and a system and method for impregnating at least one fiber roving with a polymer resin to form an asymmetric tape are provided. The asymmetric tape includes a polymer resin, and a plurality of fibers embedded in the polymer resin to form a fiber reinforced polymer material. The fiber reinforced polymer material includes a first surface and an opposing second surface. The fibers are disposed in the fiber reinforced polymer material to form a resin rich portion and a fiber rich portion. The resin rich portion includes the first surface and the fiber rich portion includes the second surface.

Abstract: The present invention relates to asphalt compositions. The present invention provides for a sulfur rubber asphalt binder composition that includes a base asphalt having a softening point, elemental sulfur, and a crumb rubber material. The crumb rubber material is combined with the base asphalt and the elemental sulfur to create the sulfur rubber asphalt binder composition. The crumb rubber material is present in the sulfur rubber asphalt binder in an amount effective to increase the softening point as compared to the softening point of the base asphalt.

Abstract: Obtaining a natural or synthetic agalmatolite containing a narrow and controlled particle distribution range, can be obtained by a high-energy million process associated to a high performance aerodynamic particle size analysis, the final use of this product being the paint industry, imparting texture, silky luster, fineness, opacity, wet scrub resistance and whiteness to the paint.

Abstract: A nonionic surfactant composition including: a nonionic surfactant that contains a molecule having a C10-C22 alkyl group and/or alkenyl group as a hydrophobic group, a polyoxyalkylene chain as a hydrophilic group, no aromatic ring, no C9-C14 alkyl group derived from an alcohol that is produced from a higher olefin derived from a mixture of propylene and butene through an oxo process, and no C13 alkyl group derived from an alcohol that is produced from a higher olefin derived from a propylene tetramer through an oxo process. The nonionic surfactant has a hydrodynamic radius of 5.0 to 8.0 nm at 40° C. in an aqueous solution in which a nonionic surfactant concentration is 0.1 kg/L in the nonionic surfactant composition, the radius being measured by a dynamic light scattering method.