Patents Issued in May 2, 2017
  • Patent number: 9637690
    Abstract: An oxidative treatment system, e.g., oxidative desulfurization or denitrification, is provided in which the oxidant is produced in-situ using an aromatic-rich portion of the original liquid hydrocarbon feedstock. The process reduces or replaces the need for the separate introduction of liquid oxidants such as hydrogen peroxide, organic peroxide and organic hydroperoxide in an oxidative treatment process.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: May 2, 2017
    Assignee: Saudi Arabian Oil Company
    Inventors: Omer Refa Koseoglu, Abdennour Bourane
  • Patent number: 9637691
    Abstract: The present invention relates to hydrogen sulfide scavenging additive composition comprising glyoxal and a polymer compound which is polymer made from propylene oxide, which is capable of scavenging or removing hydrogen sulfide in hydrocarbons or hydrocarbon streams without causing any problem. The present invention is also relates to a method of scavenging hydrogen sulfide employing present scavenging additive composition comprising glyoxal and a polymer compound which is polymer made from propylene oxide. The present invention is also relates to a method of using hydrogen sulfide scavenging additive composition comprising glyoxal and a polymer compound which is polymer made from propylene oxide.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: May 2, 2017
    Assignee: Dorf Ketal Chemicals (India) Private Limtied
    Inventor: Mahesh Subramaniyam
  • Patent number: 9637692
    Abstract: The hydroisomerization catalyst of the present invention is a catalyst used for hydroisomerization of a hydrocarbon, including a support including a calcined zeolite modified with at least one metal selected from the group consisting of Na, K, Cs, Mg, Ca, Ba, and K, and having a thermal history that includes heating at 350° C. or more, and at least one inorganic oxide selected from the group consisting of alumina, silica, titania, boria, zirconia, magnesia, ceria, zinc oxide, phosphorus oxide, and a composite oxide containing a combination of at least two or more of these oxides; and at least one metal supported on the support and selected from the group consisting of elements belonging to Groups 8 to 10 of the periodic table, molybdenum and tungsten.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: May 2, 2017
    Assignee: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Yoshiyuki Nagayasu, Kazuaki Hayasaka, Hideki Ono, Takaya Matsumoto
  • Patent number: 9637693
    Abstract: Disclosed herein is an improved fluidized catalytic cracking process for converting normally liquid hydrocarbon feedstock with simultaneous reduction of sulfur content in the liquid products obtained therefrom which comprises carrying out the cracking process in the presence of carbon monoxide gas as a reducing agent. The process optionally includes a step of premixing the hydrocarbon feedstock with carbon monoxide gas causing major sulfur reduction before effecting the cracking. The premixing is done in a specified nozzle assembly linked to the FCC unit.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: May 2, 2017
    Assignee: INDIAN OIL CORPORATION LTD.
    Inventors: Pankaj Kumar Kasliwal, Brijesh Kumar Verma, Ganga Shanker Mishra, Arumugam Velayutham Karthikeyani, Latoor Lal Saroya, Mohan Prabhu Kuvettu, Brijesh Kumar, Santanam Rajagopal, Ravinder Kumar Malhotra
  • Patent number: 9637694
    Abstract: The invention relates to a process for upgrading pyrolysis tar, such as steam cracker tar, in the presence of a utility fluid. The utility fluid contains 2-ring and/or 3-ring aromatics and has solubility blending number (SBN)?120. The invention also relates to the upgraded pyrolysis tar and to the use of the upgraded pyrolysis tar, for example, for fuel oil blending.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 2, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Christopher M. Evans, Nikolaos Soultanidis, Reyyan Koc-Karabocek, David T. Ferrughelli, Teng Xu
  • Patent number: 9637695
    Abstract: Reactor for producing a product gas from a fuel having a housing (11, 12, 13) with a combustion part accommodating a fluidized bed (7) in operation, a riser (2) extending along a longitudinal direction of the reactor (1), and a downcomer (3) positioned coaxially around the riser (2) and extending into the fluidized bed (7). One or more feed channels (8) for providing the fuel to the riser (2) are provided. The riser (2) is attached to the housing (11, 12, 13) of the reactor (1) in a bottom part (13) of the housing (11, 12, 13), and a part of the riser (2) above the one or more feed channels (8) is moveable with respect to the downcomer (3) in the longitudinal direction of the reactor (1).
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: May 2, 2017
    Assignee: STICHTING ENERGIEONDERZOEK CENTRUM NEDERLAND
    Inventors: Robin Willem Rudolf Zwart, Christiaan Martinus Van Der Meijden, Abraham Van Der Drift
  • Patent number: 9637696
    Abstract: A pressure control system is provided. The pressure control system includes a first pressure sensing device configured to obtain a first pressure measurement including at least one of a first differential pressure and a first pressure, the first pressure measurement obtained from at least one of within and downstream from a solids supply system, a second pressure sensing device configured to obtain a second pressure measurement including at least one of a second differential pressure and a second pressure within the solids supply system, and a pressure controller configured to use the first pressure measurement and the second pressure measurement to control a pressure within the solids supply system.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 2, 2017
    Assignee: General Electric Company
    Inventors: John Saunders Stevenson, Judith Pauline Oppenheim, Anthony Holmes Furman, Thomas Frederick Leininger, Steven Craig Russell, Michael Kent Cueman
  • Patent number: 9637697
    Abstract: This application relates to the polymorphism and microstructure of certain triacylglycerols and fatty acid methyl esters, and how the properties of these individual components in a biodiesel fuel, as well as their combined mixtures, helps understand the fundamental mechanisms of their crystallization so as to design biodiesel fuels with improved low temperature characteristics.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 2, 2017
    Assignee: Trent University
    Inventors: Suresh Narine, Laziz Bouzidi, Bruce Darling, Mark Baker, Shaojun Li, Ali Mahdevari
  • Patent number: 9637698
    Abstract: This application relates to certain dimers as crystallization depressants for biodiesel fuels, and methods for making the same. Such dimers, due to their particular structure and conformation, disrupt the regular packing of linear saturated fatty acid methyl esters, thereby delaying nucleation and mitigating crystal growth. In some embodiments, the dimer includes (E)-1-(1-(oleoyloxy)-3-(stearoyloxy)propan-2-yl) 18-(1-(oleoyloxy)-3-(stearoyloxy)propan-2-yl)octadec-9-enedioate.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 2, 2017
    Assignee: Trent University
    Inventors: Suresh Narine, Laziz Bouzidi, Bruce Darling, Mark Baker, Shaojun Li, Ali Mahdevari
  • Patent number: 9637699
    Abstract: Processes for producing a fuel from a renewable feedstock which may have more than 60 ppm nitrogen. The renewable feedstock is passed to a deoxygenation zone. A hydrogen stream, preferably formed from a recycled gas, is introduced into the deoxygenation zone at a relatively high rate. The hydrogen introduction may be between 3 to 5 times the rate of hydrogen consumption in the deoxygenation zone. The hydrogen introduction may also be between 6000 to 9000 SCF/BBL. A deoxygenated effluent, comprising less than 1 wppm nitrogen, may be isomerized and separated into one or more product hydrocarbon streams such as a diesel fuel or aviation fuel.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: May 2, 2017
    Assignee: UOP LLC
    Inventors: Daniel Ellig, Donald A. Eizenga
  • Patent number: 9637700
    Abstract: Provided herein are compositions comprising at least one estolide compound of formula: in which n is an integer equal to or greater than 0; m is an integer equal to or greater than 1; R1, independently for each occurrence, is selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; and R3 and R4, independently for each occurrence, are selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched. Also provided are uses of the compositions described herein.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: May 2, 2017
    Assignee: Biosynthetic Technologies, LLC
    Inventors: Travis Thompson, Jakob Bredsguard, Jeremy Forest
  • Patent number: 9637701
    Abstract: A method for preparing a ketone group-containing estolide compound and a ketone group-containing estolide compound prepared thereby are disclosed. The method for preparing a ketone group-containing estolide compound includes converting biomass fat into a fatty acid; separating the fatty acid into a C16 saturated fatty acid and a C18 unsaturated fatty acid; increasing an amount of oleic acid through partial hydrogenation of the C18 unsaturated fatty acid; synthesizing a C35 ketone through ketonization of the oleic acid; and performing estolide bonding by capping the C16 saturated fatty acid onto the C35 ketone.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: May 2, 2017
    Assignees: SK Innovation Co., Ltd., SK Lubricants Co., Ltd.
    Inventors: Yong Woo Kim, Hee Jung Jeon, Wan Seop Kwon, Hak Mook Kim, Jin Hee Ok
  • Patent number: 9637702
    Abstract: A lubricant composition for 4-stroke or 2-stroke marine engine includes at least one lubricant base oil for marine engine, at least one olefin copolymer, at least one hydrogenated styrene-isoprene copolymer, at least one glycerol ester and at least one detergent, whose use promotes fuel economy and has good properties regarding engine cleanliness, in particular crankcase cleanliness.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: May 2, 2017
    Assignee: Total Marketing Services
    Inventor: Denis Lancon
  • Patent number: 9637703
    Abstract: The lubricating oil composition of the invention comprises a lubricating base oil with a 100° C. kinematic viscosity of 1-20 mm2/s, (A) a friction modifier, (B) a first overbased metal salt obtained by overbasing an oil-soluble metal salt with an alkaline earth metal borate, and (C) an overbased second oil-soluble metal salt obtained by overbasing an oil-soluble metal salt with an alkaline earth metal carbonate.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: May 2, 2017
    Assignee: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Shigeki Matsui, Akira Yaguchi, Akio Mutou, Mari Nagae
  • Patent number: 9637704
    Abstract: A lubricant composition comprises as a lubricant base, an oil soluble polyalkylene glycol suitable for use as a lubricant in an industrial oil, grease or metal working fluid; and an additive comprising (1) alkylated phenyl-?-naphthylamine; and (2) 2,2,4-trialkyl-1,2-dihydroquinoline.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: May 2, 2017
    Assignee: VANDERBILT CHEMICALS, LLC
    Inventors: Junbing Yao, Steven G. Donnelly
  • Patent number: 9637705
    Abstract: A gun oil composition adapted specifically for the needs and requirements of modern firearms. The gun oil composition improves lubricity and gun performance under normal and extreme heat and pressure, minimizes and largely prevents the build-up of carbon and debris fouling on metal and non-metal components of the firearm, and substantially reduces cleaning time, while providing increased protection against environmental components such as dust, dirt and rust. The gun oil composition can include a base oil having at least a high viscosity index, an oil having at least a medium viscosity index with a detergent additive, a low viscosity penetrating oil, and a sulfurized ester.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: May 2, 2017
    Assignee: Mongoose Lubricants, LLC
    Inventor: Leonard A. Waldron
  • Patent number: 9637706
    Abstract: Disclosed are methods of improving the sensory and oxidative stability of oils (e.g., plant and animal oils) by combining an oil and an antioxidant composition comprising green tea extract and deodorizing the oil. Oils prepared by these methods are also disclosed.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: May 2, 2017
    Assignee: DSM IP Assets B.V.
    Inventor: Weerasinghe M. Indrasena
  • Patent number: 9637707
    Abstract: The present invention relates to compounds of formula wherein one R group is a hydrogen atom and the other is a hydrogen atom or a C1-3 alkyl group; and each carbon-carbon double bond of said compound, independently from each other, can be in a configuration Z or E or a mixture thereof; which are useful perfuming ingredients.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: May 2, 2017
    Assignee: Firmenich SA
    Inventor: Peter Fankhauser
  • Patent number: 9637708
    Abstract: Alkaline sprayable aqueous compositions are disclosed. In particular, sprayable alkaline aqueous chlorine compositions including a surfactant system for modifying the viscosity of the composition, are combined with an alkalinity source and a chlorine source. Methods of cleaning having reduced amounts of airborne particulates of the composition during spray applications are also provided according to the invention, namely reduction of airborne particulates having a micron size of 10 or less within a breathing zone of a user of less than or equal to 60 particles/cm3.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: May 2, 2017
    Assignee: Ecolab USA Inc.
    Inventors: Charles Allen Hodge, Christopher Michael McGuirk, Amanda Ruth Blattner, Claire Lucille Notermann
  • Patent number: 9637709
    Abstract: The invention discloses detergent compositions containing acrylic acid polymers, including methacrylic acid/ethyl acrylate polymers. In certain embodiments compositions employ an acrylic acid polymer comprising at least 40 wt-% polymerized residues of acrylic monomers, at least 50 wt-% of at least one surfactant, a solvent, at least one water conditioning polymer, and water. The detergent compositions provide increased soil removal and soil suspension when treating textiles, namely through use of industrial laundering machinery. The detergent compositions and methods of employing the same beneficially clean and prevent redeposition of soils containing high concentrations of oil and metal particulates, as are customary in industrial laundering soils.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: May 2, 2017
    Assignee: Ecolab USA Inc.
    Inventor: Jonathan P. Fast
  • Patent number: 9637710
    Abstract: A hard surface cleaning composition comprising: a) from 1% to 60% by weight of the composition of a surfactant system comprising an anionic surfactant and a primary co-surfactant selected from the group consisting of amphoteric, zwitteronic and mixtures thereof; and b) from 0.1% to 10% by weight of the composition of a polyetheramine.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: May 2, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Frank Hulskotter, Patrick Firmin August Delplancke, Gloria Di Capua, Bjoern Ludolph, Stefano Scialla
  • Patent number: 9637711
    Abstract: Compositions and methods for removing surface deposits in situ from filtration media contained in water filtration beds may include a solid acid component, a solid oxidizer, low temperature activator, a dessicant, an anti-caking agent, a pH indicator, a corrosion inhibitor, a surfactant, a chelating agent, and/or a defoaming agent. A granular acid component may include sodium bisulfate, and a granular oxidizing component may include at least one of sodium percarbonate, sodium perborate, potassium percarbonate, and potassium perborate. Compositions may be applied to top surface and/or subsurface regions of a filter bed, in wetted or dry form. A kit includes a container with dry composition and instructions or indicia for cleaning water filtration media using the composition.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: May 2, 2017
    Assignee: Blue Earth Labs, LLC
    Inventors: Dane H. Madsen, Jason E. Peters, Jeffrey Schulhoff, Jeffrey Bryan Schulhoff
  • Patent number: 9637712
    Abstract: An improved system and process for rapidly producing distilled spirits having characteristics associated with a much longer maturation process is provided. The method involves contacting wood with an unmatured distilled spirit under heated conditions and contacting the resulting heat-treated spirit with actinic light. The disclosure provides embodiments where a spirit is sequentially processed through heat and actinic light treatment. The disclosure also provides embodiments where a heat-treated spirit is mixed with a spirit that has been separately treated with light to give characteristics of a mature spirit.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: May 2, 2017
    Assignee: LOST SPIRITS DISTILLERY, LLC
    Inventor: Bryan Alexander Davis
  • Patent number: 9637713
    Abstract: An improved system and process for rapidly producing distilled spirits having characteristics associated with a much longer maturation process is provided. The method involves contacting wood with an unmatured distilled spirit under heated conditions and contacting the resulting heat-treated spirit with actinic light. The disclosure provides embodiments where a spirit is sequentially processed through heat and actinic light treatment. The disclosure also provides embodiments where a heat-treated spirit is mixed with a spirit that has been separately treated with light to give characteristics of a mature spirit.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: May 2, 2017
    Assignee: LOST SPIRITS DISTILLERY, LLC
    Inventor: Bryan Alexander Davis
  • Patent number: 9637714
    Abstract: A scalable photobioreactor system for efficient production of photosynthetic microorganisms such as microalgae and cyanobacteria is described. In various embodiments, this system may include the use of extended surface area to reduce light intensity and increase photosynthetic efficiency, an external water basin to provide structure and thermal regulation at low cost, flexible plastic or composite panels that are joined together make triangular or other shapes in cross-section when partially submerged in water, use of positive gas buoyancy and pressure to maintain the structural integrity of the photobioreactor chambers and use of structure to optimize distribution of diffuse light. Other embodiments concern air tubes comprised of plastic film at the bottom of each photobioreactor chamber to provide sparging air bubbles to the chamber. The photobioreactor system design also comprises gas exchange, temperature control, air pumping, liquid pumping, filtration, media recycling and harvesting methods.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: May 2, 2017
    Assignee: Colorado State University Research Foundation
    Inventors: Bryan Willson, Guy Babbitt, Christopher Turner, Peter Letvin, Kristina Weyer-Geigel, Anna Ettinger, Amy Boczon, Nicholas Rancis, James Murphy
  • Patent number: 9637715
    Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.
    Type: Grant
    Filed: April 1, 2012
    Date of Patent: May 2, 2017
    Assignee: EMD Millipore Corporation
    Inventors: Paul J. Hung, Philip J. Lee
  • Patent number: 9637716
    Abstract: A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: May 2, 2017
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Martin Dahlberg, Isabelle Gay, Lars Boettcher, Stefan Obermann, Rainer Sandrock
  • Patent number: 9637717
    Abstract: A system and method for compartmentalizing micro-carriers in a bioreactor includes a container configured to store micro-carriers and a vessel configured to contain a fluid so as to prevent the micro-carriers from entering the vessel during sterilization, shipping, storage, or other pre-use handling of the system. One or more addition lines connect the container and the vessel such that the vessel is in fluid communication with the vessel. The one or more addition lines are contactable by at least one blocking element configured to reversibly block fluid flow between the container and the vessel. The container, addition lines, and vessel are configured to allow the micro-carriers to be injected into the vessel at any point during a cell culture run. The vessel may also include a rotatable wheel, a harvest port configured to allow for the removal of the micro-carriers from the vessel, and a media removal port comprising a retention screen for removing spent medium.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: May 2, 2017
    Assignee: PBS Biotech, Inc.
    Inventors: Chanyong Brian Lee, Yasunori Hashimura
  • Patent number: 9637718
    Abstract: The present invention includes a microfluidic device comprising one or more parking loops 12, each parking loop 12 comprising a bypass channel 14 and a lower branch 16 capable of retaining one or more drops, wherein bypass channel 14 has a smaller hydrodynamic resistance than the lower branch 16.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: May 2, 2017
    Assignee: Texas Tech University System
    Inventors: Siva A. Vanapalli, Swastika S. Bithi, Meng Sun
  • Patent number: 9637719
    Abstract: This invention relates to devices and methods for purifying biological cells. For example, viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a column, including a pipette tip column. Cells can be purified in a sealed chromatographic system. Methods of the invention can aid research, diagnosis and treatment of cancer.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: May 2, 2017
    Inventor: Douglas T. Gjerde
  • Patent number: 9637720
    Abstract: The invention relates to a method for multiplying a strain of Trichoderma, which includes the preparation of substantially contaminant-free culture media, containing disinfected wood fibers obtained by means of a twin-screw extruder, the amplification of Trichoderma via a series of steps for manufacturing a primary inoculum and then a secondary inoculum from said primary inoculum, and the multiplication of the microorganisms in each step, wherein the multiplication of the propagules reaches 2×104 to 105. The invention also relates to a plant growing medium containing a secondary inoculum of Trichoderma.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: May 2, 2017
    Assignees: FLORENTAISE, NIXE
    Inventors: Jerome R. Cowper, Renaud H. Canaguier, Helene L. Reynaud
  • Patent number: 9637721
    Abstract: The present disclosure relates, in general, to a media, e.g., a serum replacement, media supplement, complete media or cryopreservation media, comprising a base physiological buffer and liposomes comprising cholesterol, phosphatidylcholine and fatty acids. It is contemplated that media provides advantages to improve cell growth in culture compared to cells cultured not using the serum replacement described herein.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 2, 2017
    Assignee: BIO-ESS LABORATORIES, LLC.
    Inventors: Adam Elhofy, Allan Weber
  • Patent number: 9637722
    Abstract: A polyurethane porous membrane is produced by a simple method to be used for at least one of applications of cell culture and cancer cell growth inhibition. The production method of the polyurethane porous membrane to be used for at least one of the applications of cell culture and cancer cell growth inhibition comprises: a first step of forming a layer of a polyurethane material which is uncured, on a substrate; and a second step of supplying water vapor to an exposed surface of the layer of the polyurethane material formed on the substrate, which is away from the substrate, so as to cure the polyurethane material and provide the layer of the polyurethane material with a porous structure having a plurality of irregularities on the exposed surface.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: May 2, 2017
    Assignees: TOYODA GOSEI CO., LTD., National University Corporation Yamagata University
    Inventors: Seitaro Taki, Hisashi Mizuno, Hiroyuki Nakagawa, Toshiyuki Hagiyama, Atsuki Yoshimura, Masaru Tanaka, Ayano Sasaki, Toshifumi Takahashi, Tsuyoshi Ohta
  • Patent number: 9637723
    Abstract: This disclosure is directed to methods for reproducibly generating substantial amounts of endothelial cells from amniotic cells. The endothelial cells generated in accordance with the present methodology, as well as therapeutic methods utilizing these cells, are also disclosed.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: May 2, 2017
    Assignee: CORNELL UNIVERSITY Q
    Inventors: Shahin Rafii, Sina Y. Rabbany, Michael Ginsberg
  • Patent number: 9637724
    Abstract: A method of selectively separating a biological target from a sample including the biological target material or suspected of including the biological target includes the steps of (i) providing a solid including ureide moieties at its surface, (ii) contacting the sample with the solid, whereby a substantial fraction of the biological target in the sample binds to the ureide moieties, and (iii) separating the solid from the sample.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 2, 2017
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Peter Gagnon
  • Patent number: 9637725
    Abstract: Provided are isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: May 2, 2017
    Assignee: Novozymes Inc.
    Inventors: Ye Liu, Junxin Duan, Yu Zhang, Lan Tang
  • Patent number: 9637726
    Abstract: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 2, 2017
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith Bauer, Thomas W. Myers, Fred Reichert, Joseph San Filippo, Rachel Shahinian, Shawn Suko
  • Patent number: 9637727
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: May 2, 2017
    Assignee: Novozymes, Inc.
    Inventor: Nikolaj Spodsberg
  • Patent number: 9637728
    Abstract: The present invention provides T. reesei endoglucanase I variants exhibiting improved cellulase and/or xylanase activity, in particular at 30° C. and/or pH 6. These variants are particularly useful in industrial processes comprising simultaneous degradation of cellulosic biomass into monomeric sugars and fermentation of said sugars, for example to produce ethanol.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: May 2, 2017
    Assignee: BIOMETHODES
    Inventors: Stéphane Blesa, Céline Coursange, Bruno Winter
  • Patent number: 9637729
    Abstract: The invention relates to immobilized or encapsulated enzyme and/or cells to lower bile acids and cholesterol. The invention also relates to methods of quantitatively measuring bile acids. The invention provides a composition for decreasing the amount of a target compound in the gastrointestinal tract of an animal, comprising: a) a biologically active agent which decreases the amount of the target compound; b) a retainer for retaining the biologically active agent by contacting the agent to limit movement of the agent; and c) a carrier.
    Type: Grant
    Filed: December 20, 2014
    Date of Patent: May 2, 2017
    Assignee: UAS Laboratories LLC
    Inventors: Satya Prakash, Mitchell Lawrence Jones
  • Patent number: 9637730
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: May 2, 2017
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
  • Patent number: 9637731
    Abstract: A method for inhibiting methane production in naturally occurring or induced reducing conditions, thus subsequently resulting into inhibition of the biomethylation process of the heavy metals is disclosed. The disclosed inhibiting composition blocks 3-hydroxy-3-ethylglutaryl coenzyme A (HMG-CoA) reductase, and 8-hydroxy-5-deazaflavin (coenzyme F420) in the methane production pathway, due to the presence of lovastatin in the red yeast rice. As a result the methanogens are unable to produce enough quantities of methane that will result to the production of methylmetal(loids), which are usually volatile and more toxic than their inorganic counterparts due to increased water solubility and hydrophobicity.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: May 2, 2017
    Assignee: Innovative Environmental Technologies, Inc.
    Inventors: Michael Scalzi, Antonis Karachalios
  • Patent number: 9637732
    Abstract: Provided is a method of improving the efficiency of iPS cell establishment, comprising bringing one or more factors selected from the group consisting of proteins belonging to cyclin D family and nucleic acids that encode the same into contact with a somatic cell, in the step of nuclear reprogramming of the somatic cell. Also provided are a method of producing an iPS cell comprising the step of bringing the factor(s) and nuclear reprogramming substance(s) into contact with a somatic cell, an iPS cell comprising a nucleic acid that encodes a protein belonging to cyclin D family that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: May 2, 2017
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Kazutoshi Takahashi, Koji Tanabe, Hong Hyenjong
  • Patent number: 9637733
    Abstract: A reagent supply device includes a plurality of chambers which are separated from each other such that different reagents may be injected, the plurality of chambers having bottom surfaces made of a membrane, the membrane comprising a destruction pattern which is formed at a position corresponding to each of the plurality of chambers and breachable by an external impact to discharge the injected reagent from the chamber.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: May 2, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Chin-sung Park, Kak Namkoong, Joon-sub Shim, Won-seok Chung, Kyung-ho Kim, Joon-ho Kim, Won-jong Jung
  • Patent number: 9637734
    Abstract: This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: May 2, 2017
    Assignee: BioAtla, LLC
    Inventors: Jay M. Short, Hwai Wen Chang, Gerhard Frey
  • Patent number: 9637735
    Abstract: This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: May 2, 2017
    Assignee: BioAtla, LLC
    Inventors: Jay M. Short, Hwai Wen Chang, Gerhard Frey
  • Patent number: 9637736
    Abstract: The invention provides DNA molecules and constructs, and their nucleotide sequences, useful for modulating gene expression in plants, and for specifying intracellular or extracellular localization of a gene product of interest. Transgenic plants, plant cells, plant parts, and seeds, comprising the DNA molecules operably linked to heterologous transcribable polynucleotides are also provided.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: May 2, 2017
    Assignee: Monsanto Technology LLC
    Inventors: Stanislaw Flasinski, Charles R. Dietrich, Wei Wu, Zhaolong Li, Bo-Xing Qiu, Liang Guo, Jaishree M. Chittoor
  • Patent number: 9637737
    Abstract: The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: May 2, 2017
    Assignee: NEC SOLUTION INNOVATORS, LTD.
    Inventors: Naoto Kaneko, Katsunori Horii, Jou Akitomi, Shintarou Katou, Iwao Waga
  • Patent number: 9637738
    Abstract: Agents and methods for increasing dystrophin protein expression in muscle through blocking of specific microRNAs and microRNA binding sites on the dystrophin 3? untranslated region (miR-146a, miRNA-146b, miR-223, miR-320a, miR374a, and miR-382). Methods for increasing the amount of dystrophin useful for effective therapeutic intervention for Becker muscular dystrophy, Duchenne muscular dystrophy, and other disorders where loss of dystrophin from muscle causes pathology.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: May 2, 2017
    Assignee: Reveragen Biopharma, Inc.
    Inventors: Eric Hoffman, Alyson Fiorillo
  • Patent number: 9637739
    Abstract: Isolation or in vitro assembly of the Cas9-crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system and use for cleavage of DNA bearing a nucleotide sequence complementary to the crRNA and a proto-spacer adjacent motif. Methods for site-specific modification of a target DNA molecule using an RNA-guided DNA endonuclease comprising at least one RNA sequence and at least one of an RuvC active site motif and an HNH active site motif; for conversion of Cas9 polypeptide into a nickase cleaving one strand of double-stranded DNA by inactivating one of the active sites (RuvC or HNH) in the polypeptide by at least one point mutation; for assembly of active polypeptide-polyribonucleotides complex in vivo or in vitro; and for re-programming a Cas9-crRNA complex specificity in vitro or using a cassette containing a single repeat-spacer-repeat unit.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 2, 2017
    Assignee: VILNIUS UNIVERSITY
    Inventors: Virginijus {hacek over (S)}ik{hacek over (s)}nys, Giedrius Gasiunas, Tautvydas Karvelis