Abstract: Embodiments of a simulated valve device can be used to determine whether a valve device would fit within a particular airway. The simulated valve device can include a shaft having at least one strut extending radially therefrom. The strut and at least part of the shaft can be surrounded by a membrane for viewing through a bronchoscope. In some embodiments, the membrane can include markings for viewing by a user.

Abstract: Devices and methods for measuring size of airways to lung are disclosed. A light-based endoluminal sizing device can comprise a centering tool, a light source, and a marker. A size of an airway can be approximated or determined based on a distance between the marker and the light source when light from the light source intersects the marker at an interface between the marker and the airway wall. In some cases, the size of the airway can be approximated from observing an intersection between a light pattern and the airway wall.

Abstract: An interactive virtual care system may include a user sensory module to acquire multi-modal user data related to user movement. A data analysis module may compare the multi-modal user data to predetermined historical user data and/or statistical norm data for users to identify an anomaly in the user movement.

Abstract: Provided is an examination system including a mobile apparatus and an examination apparatus. The mobile apparatus includes: a biological object information storing unit configured to store biological object information; a reading unit configured to read biological object information; a comparing unit configured to compare the biological object information; and an outputting unit configured to output a result of comparison, and the examination apparatus includes: an examination information acquiring unit configured to acquire examination information; and a controlling unit configured to control the operation of the examination apparatus.

Abstract: A receptor capable of binding to the target analyte can be used in monitoring a target analyte in a bodily fluid or a sample. A microdevice in accordance with the disclosed subject matter can include a substrate and a conductance elements with receptors grafted on the surface of the conductance element. A microdevice in accordance with the disclosed subject matter can also include a substrate, a first and second conductance elements, and synthetic polymers grafted on the surface of the first and second conductance elements. The first conductance element can be grafted with a sensing polymer that binds the target analyte, and the second conductance element can be grafted with a reference polymer that is insensitive to the target analyte. Differential measurement of the graphene conductance can allow determination of target analyte concentration in a bodily fluid.

Abstract: A light-based method and technique for measuring the static and average plasma glucose concentration over a prolonged period of time. More specifically, the disclosure relates to a method that utilizes mathematical analysis of appendage mobile LED flash IR light transmittance, absorption and scattering by using high resolution mobile camera data to estimate the concentration of glucose and glycated hemoglobin (HbA1c) in millimoles per liter (mmol/L).

Abstract: An unscented Kalman filter is used to enable sensor calibration independently of the actual design of the subject sensors. By utilizing an unscented Kalman filter, an underlying calibration methodology is developed that is sensor-unspecific, such that a single calibration methodology and related systems may be used to calibrate various sensors, without the need to re-calculate a calibration factor for each specific sensor, and without the need to design a separate filtering mechanism to compensate for noise. In this way, various calibration inputs can be allowed to change over time without the need to change the codebase on which the calibration methodology otherwise operates. In multi-electrode systems, the methodology may incorporate a fusion algorithm to provide a single, fused sensor glucose value. The fusion algorithm may incorporate, and/or work in conjunction with, Electrochemical Impedance Spectroscopy (EIS) procedures.

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Abstract: Implantable sensor apparatus and methods of implantation. In one embodiment, a fully implantable, biocompatible sensor is disposed within a cavity or pocket formed within a living being, such that the sensor remains in a desired orientation and placement so as to enhance the performance of the sensor, and mitigate the effects of one or more factors potentially deleterious to the operation of the sensor and the host being. In one implementation, the sensor comprises an implantable biocompatible oxygen-based glucose sensor which is implanted deep within the being's torso tissue proximate the extant fascia, and oriented such that an active detector aspect of the device faces away from the being's skin surface. In one variant, the deep placement, orientation, and construction of the sensor itself cooperate to enhance the performance of the sensor, especially over extended periods of time, with little need for external calibration.

Abstract: Diagnostic mouthpieces and separate pads for same allow dental devices of various types to have a dual purpose. The diagnostic mouthpieces allow frequent use and early intervention.

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Abstract: A single, optimal, fused sensor glucose value may be calculated based on respective sensor glucose values of a plurality of redundant working electrodes (WEs) of a glucose sensor. Respective electrochemical impedance spectroscopy (EIS) procedures may be performed for each of the WEs to obtain values of membrane resistance (Rmem) for each WE. A noise value and a calibration factor (CF) value may be calculated for each WE, and respective fusion weights may be calculated for Rmem, noise, and CF for each WE. An overall fusion weight may then be calculated based on the WE's Rmem fusion weight, noise fusion weight, and CF fusion weight, such that a single, optimal, fused sensor glucose value may be calculated based on the respective overall fusion weight and sensor glucose value of each of the plurality of redundant working electrodes.

Abstract: A remote device includes a biosensor interface that is configured to collect biosensor data from an integrated biosensor or by receiving biosensor data from one or more external biosensors or other types of sensors either through a wireless connection or a wired connection. The remote device communicates with a television to display the biosensor data on the television. The television may communicate biosensor data to third party, such as a pharmacy or physician's office or service provider.

Abstract: Methods and apparatus for acquiring data associated with a monitored analyte level, determining a glucose level based at least in part on the acquired data associated with the monitored analyte level, manipulating a data set based on a processing mode following the glucose level determination, where the processing mode includes one of a data set transmission and output display, a data set storing and output display without transmission, or a data set transmission and data set storing without output display are provided.

Abstract: An oxygen saturation measuring apparatus is provided. The oxygen saturation measuring apparatus includes a sensor configured to detect motion of the oxygen saturation measuring apparatus, a light emitter comprising light emitting circuitry configured to emit light to a target subject, a light receiver comprising light receiving circuitry configured to receive one or more of light reflected by the target subject or light transmitted through the target subject to generate a signal, and a processor configured to filter a frequency component corresponding to the detected motion in the signal, to detect a pulse frequency from the filtered signal, and to determine oxygen saturation of the target subject using the filtered signal and the detected pulse frequency.

Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.

Abstract: A medical device is presented for reduced-pain blood sampling and testing. The device comprises a housing defining a finger site for supporting a user's finger or a portion thereof within said finger site during the device operation; piercing, sampling and testing assemblies sequentially actuatable to successively initiate piercing, sampling and testing operational modes of the device; a carriage at least partially accommodated within said housing and being adapted for movement with respect to said finger site between its first position corresponding to the piercing mode of the device and a second position corresponding to the sampling and testing modes of the device, the device being thereby capable of operating in the piercing, sampling and testing modes while at a static position of the user's finger.

Abstract: The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for incubation in culture media in one or more sample vessels. Prior to withdrawing bodily fluid into the one or more sample vessels for incubation, an initial volume of withdrawn bodily fluid is placed in one or more pre-sample reservoirs and is not used for the incubation in culture media.

Abstract: Described herein is an onboard vehicle system capable of determining that a driver of a vehicle is distracted and implementing one or more distraction settings to mitigate unsafe driving conditions. In some embodiments, the onboard vehicle system includes one or more input sensors configured to gather input related to a driver, one or more component adjusters configured to adjust attributes of a vehicle component, and a processor device configured to receive input from the one or more input sensors, determine whether the driver is distracted, and activate the one or more component adjusters. In some embodiments, the onboard vehicle system may be in communication with a service provider computer configured to maintain a user account for a driver along with a driver distraction profile.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for analyzing data include: receiving data including a person's responses regarding judgments of semantic similarities between items selected from a group of items falling into a same categorical level; processing the data to determine a measure of distance within a generated representation of the person's responses regarding the judgments of semantic similarities; and generating a score of degree of cognitive impairment for the person based at least in part on the determined measure of distance within the generated representation.

Abstract: There is provided herein a method and a device for measuring, using one or more breath sensors, a metabolic product of a fatty acid, a salt or a derivative thereof, in the subject's breath after administering to the subject an isotope labeled fatty acid, a salt or a derivative thereof, obtaining the subject's level of insulin, glucose, glucagon or a combination thereof and using a processing circuitry, evaluating the liver condition based on the subject's metabolic product of the fatty acid, salt or derivative thereof and the level of insulin, glucose, glucagon or a combination thereof.

Abstract: A monitoring system comprising: a uterine insert comprising an insert extension, wherein the insert extension comprises at least one sensor; a deployment module engageable with the insert, and configured to allow the insert extension to bend when the module is engaged with the insert; a system control device operationally coupled to continuously receive signals from the at least one sensor and to convert the signals into data representing the signals, and a display operationally coupled to display the data from the system control device.

Abstract: A method of determining a condition of bone structure in a living organism includes impacting a bone to induce vibration in multiple modes having a resonance frequency in a range of about 400 Hz to about 1000 Hz, detecting at least one modal vibration response of the bone for the at least one mode of vibration, and analyzing the at least one modal vibration response to determine a modal vibration characteristic of the bone. A system for determining a condition of bone structure in a living organism includes a force input device configured to impact a bone to induce vibration having a resonance frequency of about 400 Hz to about 1000 Hz, at least one sensor configured to sense at least one modal vibration response, and a computer configured to collect modal vibration response data and analyze the modal vibration response data to determine a vibration characteristic of the bone.

Abstract: A method for measuring a muscle tone is used in a muscle tone measuring system including a sensing end and a processing end. The method for measuring the muscle tone includes respectively arranging the sensing end and the processing end on first and second limb parts of a limb that are interconnected by a joint of the limb. The sensing end detects a strength of a force that is applied to the first limb part and a plurality of physical quantities of a movement of the first limb part. The processing end detects an environment temperature and the physical quantities of a movement of the second limb part, and collects the physical quantities of the movements of the first and second limb parts, the environment temperature and the strength of the force according to a sampling rate during a period of measuring time. The muscle tone measuring system is also provided.

Abstract: The present invention is generally directed to apparatuses and methods for evaluating the amount of “play” in a joint. In one embodiment, an apparatus is provided that quantifies the rotation of the tibia in response to a known torque. The apparatus is configured to minimize the influence of other joints on the rotation analysis. Other embodiments provide data related to movement of the tibia in other degrees of freedom.

Abstract: The invention comprises methods and systems capable of processing simultaneously measured cardiac and motion signals, selecting from said signals the optimal cardiac and motion signal combination for cross spectral density calculations and, hereafter, itemizing the shared information in terms of the individual constituent frequencies and the effect exerted upon said frequencies by common underlying physiological states. The information is passed through a classifier, where said information is used to quantify the underlying physiological states, exemplified by but not limited to, sleep stage, quality and/or disorders that affect sleep stability. Inferences made by the methods described, for example, can be employed to aid home based sleep analysis and automated screening of patients with sleep disorders.

Abstract: An example method for detecting respiratory disturbances experienced by a subject can include receiving an airflow signal and at least one of an acoustic or vibration signal, where the airflow, acoustic, and/or vibration signals are associated with the subjects breathing. At least one feature can be extracted from the airflow signal and at least one feature can be extracted from at least one of the acoustic or vibration signal. Based on the extracted features, at least one respiratory disturbance can be detected. The respiratory disturbance can be flow limited breath or inspiratory flow limitation (“IFL”).

Abstract: Disclosed is a method of monitoring consciousness, the method including sensing at least two brainwave signals, extracting respective phase signals from the sensed brainwave signals, calculating entropy based on a variety in a change in terms of a phase difference between the extracted phase signals, and assessing a state of consciousness based on the calculated entropy.

Abstract: A transition monitor receives data from a variety of sensors that provide data indicative of the level of sedation of a patient, such as a bispectral index monitor, automated responsiveness monitor, pulse oximeter, or other device. As data is received from a sensor device, the transition monitor will apply a weighting calculation and algorithm to the received value in order to determine a weighted value for the received data. The weighted value is used, along with prior values, to determine a sedated patient's position within a continuum of sedation levels, such as minimal sedation, moderate sedation, or deep sedation. When a newly received value triggers a transition from one sedation level to a next sedation level, one or more thresholds, safeguards, or drug delivery configurations may be modified to adapt to the change within the sedation continuum.

Abstract: An alcohol consumption determination method includes: detecting an effective frame of an input voice signal; detecting a difference signal of an original signal of the effective frame; performing fast Fourier conversion on the original signal and the difference signal; and determining, in the frequency domain, whether alcohol has been consumed based on a slope difference between the fast-Fourier-transformed original signal and the fast-Fourier-transformed difference signal. Accordingly, it is also possible to determine whether a driver or an operator from a remote location has consumed alcohol and a degree of the consumption, thus preventing an accident caused by an individual operating a vehicle under the influence.

Abstract: A method and system for monitoring a user's intoxication including receiving a set of signals, derived from a set of samples collected from the user at a set of time points; providing a sobriety task to the user proximal to a time point of the set of time points; generating a performance dataset characterizing performance of the sobriety task by the user; receiving a supplementary dataset characterizing a demographic profile of the user and/or a physiological state of the user; determining a set of values of an intoxication metric, derived from the set of signals; generating a predicted temporal profile of the intoxication metric for the user based upon the set of values, the set of time points, and the supplementary dataset; generating an analysis of the user's sobriety based upon the performance dataset and the predicted temporal profile; and providing a notification to the user based upon the analysis.

Abstract: A kit for assessing efficacy of a vaginal atrophy treatment regimen is disclosed. The kit includes a pretreatment assessment method for vaginal atrophy comprising and a topical treatment for application to the labia majora, labia minora, introitus, vagina, or combinations thereof.

Abstract: A system for monitoring a patient includes a sensor unit having a housing and sensors disposed in or around the housing; and a base having a shell and configured and arranged to be adhesively attached to skin of the patient. The sensors can be used to monitor physical therapy and rehabilitation of the patient. The sensor unit can provide information to a patient or clinician device to facilitate the monitoring. In some instances, the sensor unit and base are magnetically coupled together. In some instances, the base has an opening so a temperature sensor of the sensor unit can be exposed to the skin of the patient.

Abstract: Systems and methods to predict circadian phase of a subject use one or more sensors to track light exposure of the subject over a period and determine the current circadian phase. A prediction for future light exposure is used to predict a future circadian phase.

Abstract: A data acquisition device includes measuring instruments to generate physiological and/or psychological data streams. Microprocessors within the acquisition device process the generated data streams into metrics, which feed into stress function algorithms. Algorithm processing may occur either on the device, or metrics may be communicated via wireless communication for external processing on mobile devices and/or cloud-based platforms. The calculated stress functions inform cloud-based computational systems biology-derived models describing the dynamics of hormones and neurotransmitters released in the body in response to stressful stimuli. Stress hormone levels are quantified using these models, and are used in combination to serve as biologically inspired metrics of acute and chronic stress an individual is experiencing.

Abstract: A surgical system used to determine if a vessel is within a region proximate to a working end of a surgical instrument includes at least one light emitter disposed at the working end of the surgical instrument, the at least one light emitter adapted to emit light of at least two different wavelengths. The system also includes at least one light sensor disposed at the working end of the surgical instrument opposite the at least one light emitter, the at least one light sensor adapted to detect light at the at least two different wavelengths. The system further includes a controller coupled to the at least one light sensor and adapted to determine a ratio of the light absorbed at the least two different wavelengths, and to indicate if an artifact within a region proximate to the working end of the surgical instrument is a vessel based on the ratio.

Abstract: A wrist-type body composition measuring apparatus is provided to measure body composition conveniently. The wrist-type body composition measuring apparatus includes a main body, a strap, first and second inner electrodes, and first and second outer electrodes. The main body includes a measurer configured to measure a body impedance of a user and an analyzer configured to analyze a body composition of the user based on the measured body impedance.

Abstract: An apparatus comprising: a first garment configured to be worn about a torso of a patient; and a first garment identification component disposed as a part of the first garment, the first garment identification component configured to operably couple with a medical device controller, wherein the medical device controller is configured to identify the first garment based on one or more values provided by the first garment identification component.

Abstract: Disclosed are appendage mountable electronic systems and related methods for covering and conforming to an appendage surface. A flexible or stretchable substrate has an inner surface for receiving an appendage, including an appendage having a curved surface, and an opposed outer surface that is accessible to external surfaces. A stretchable or flexible electronic device is supported by the substrate inner and/or outer surface, depending on the application of interest. The electronic device in combination with the substrate provides a net bending stiffness to facilitate conformal contact between the inner surface and a surface of the appendage provided within the enclosure. In an aspect, the system is capable of surface flipping without adversely impacting electronic device functionality, such as electronic devices comprising arrays of sensors, actuators, or both sensors and actuators.

Abstract: Wearable patches comprising multiple separable adhesive layers. One or more of the layers can comprise electronics, mechanical components, gauze, medicine and/or other types of hardware suitable for the intended use of the patch. In use, a first layer of the patch is adhered to a user. When it is time to change layers, the patch is removed from the user, the first layer is removed from the patch to expose a second adhesive layer, and the second layer is applied to the user. The process may be repeated until the remaining layers of the patch have been used.

Abstract: Catheterization of the heart is carried out using a framework formed by a plurality of electrically conducting wire loops. The wire loops are modeled as polygons, each subdivided into a plurality of triangles. The wire loops are exposed to magnetic fluxes at respective frequencies, and signals read from the loops. Theoretical magnetic fluxes in the polygons are computed as sums of theoretical magnetic fluxes in the triangles thereof, The location and orientation of the framework in the heart is determined by relating the computed theoretical magnetic fluxes to the signals.

Abstract: A set is provided for applying a flat, flexible two-dimensional thin-film strip into living tissue, particularly into brain tissue. The set includes the thin-film strip itself to be applied and an application tool, which is removable and mechanically connectable to the thin-film strip by a coupling device. After application of the thin-film strip in situ the application tool is removable from the tissue without residue by mechanically disengaging the coupling device itself, while leaving the thin-film strip behind.

Abstract: System and methods for detecting one or more physiological parameters of a subject is provided. Detecting of physiological parameters can occur through a wearable device that can transmit and receive electromagnetic waves. The received electromagnetic waves are reflections from tissue of the subject. The reflections have motion and noise substantially removed. The one or more physiological parameters can be determined from motion and noise removed signals.

Abstract: Systems and methods for estimating time-dependent voltages that are induced in electrophysiological monitoring systems by magnetic field gradients generated during a magnetic resonance imaging (“MRI”) scan are provided. The gradient-induced voltages are subsequently removed from signals acquired with the electrophysiological monitoring system during an MRI scan. As an example, the electrophysiological monitoring system can include an electrocardiography (“ECG”) system, an electroencephalography (“EEG”) system, an electromyography (“EMG”) system, a voltage device tracking (“VDT”) system, and so on. The gradient-induced voltages are estimated using a two-step procedure in which a learning algorithm is used to determine fitting parameters to be used in a model of the gradient-induced voltages. The fitting parameters are then used together with the model to extract the gradient- induced voltages from signals acquired during an MRI scan. The gradient-induced voltages can then be removed from the acquired signals.

Abstract: A method of detecting an early onset of neurocardiogenic syncope in a patient uses respiratory functions as a predictor of the syncope. According to the method, at least one sample of baseline minute ventilation, tidal volume and respiratory rate of the patient is obtained. The detection unit is set to detect an increase in tidal volume and in minute ventilation over a predetermined respiratory period. The detecting unit also detects any rate of change in respiratory rate and sends a signal to a microprocessor to determine whether the increase in minute ventilation is a sole function of increased tidal volume. The impending syncope is diagnosed if variance in respiratory rate is less than 25% in relation to the sampled baseline during the predetermined period of time.

Abstract: A method and system for time varying risk profiling from sensor data includes receiving data time series from a plurality of sensors associated with a single patient, identifying events from the data, wherein an event is a transition between two states in the data of a sensor, formulating event prediction as a discrete state transition task using Markov jump processes to handle irregular sampling rates, estimating a transition density function for time varying continuous event probability using a hierarchical Bayesian model, and predicting risk events for the single patient by applying the hierarchical Bayesian model.

Abstract: In some embodiments, a method, apparatus, and a system for sensing a force are provided. The apparatus may comprise a plurality of sensors configured to detect an impact force. The plurality of sensors may be arranged into a housing, such as a sports helmet. The apparatus also includes a controller operatively coupled to the plurality of sensors. The controller is adapted to: receive a signal from at least one of the plurality of sensors; determine whether a value of the signal exceeds a threshold; perform a responsive action in response to a determination that the value of signal exceeds the threshold. The responsive action comprises providing a warning, performing a logging function, and/or performing a counteraction.

Abstract: A method for monitoring physiological status of a vehicle driver is performed by a monitoring device connected to a physiological sensor and comprises steps of: (a) establishing a personal physiological database comprising steps of: periodically sensing the vehicle driver via the physiological sensor to obtain the physiological signals within an initial duration; obtaining a mean value and a standard deviation based on the physiological signals; and obtaining a tolerance range based on the mean value and the standard deviation, such that the personal physiological database stores the tolerance range; (b) sensing the vehicle driver via the physiological sensor to obtain at least one instant physiological signal after the initial duration; and (c) determining whether the at least one instant physiological signal is out of the tolerance range, such that an alarm is outputted when the at least one instant physiological signal is out of the tolerance range.

Abstract: A method includes obtaining a set of energy dependent data generated from a spectral scan. The set of energy dependent data includes a sub-set of data corresponding to only contrast agent. The method further includes separating the sub-set of data from other data of the energy dependent data. The other data includes non-contrast agent data. The method further includes scaling the sub-set of data to change a concentration of the contrast agent in the sub-set of data from that of the sub-set of data. The method further includes visually presenting at least the scaled sub-set of data.