Abstract: Compositions including polycarbodiimide and derivatives thereof together with one of water soluble polyacid and poly carboxylic acid compounds and derivatives thereof to enhance the quality of the keratinous substrates. The present invention relates to a cosmetic treatment and process for treating keratinous materials, in particular for hair-care and hair-styling, where, according to the process, the polycarbodiimide and water soluble polyacid and poly carboxylic acid actives may be applied in a treatment that is a single step emulsion. The composition can include from about 0.2 to about 5.0%, by weight, of the composition of a combined amount of the polycarbodiimide and the polycarboxylic acid in amounts sufficient to impart hydrophobicity to keratinous substrates, including hair fibers, upon application thereto.

Abstract: The invention relates to a composition, especially a cosmetic emulsion composition, comprising at least one dispersion of film forming particles in aqueous phase and at least one hydrophobic filler, as well as to methods of using such compositions.

Abstract: Compositions including polycarbodiimide and derivatives thereof together with amino compounds and derivatives thereof chosen from polyvinylamines to enhance the quality of the keratinous substrates. The present invention relates to a cosmetic treatment and process for treating keratinous materials, in particular for hair-care and hair-styling, wherein the composition can include the polycarbodiimide and the amino compound in amounts sufficient to impart one or more of increased hydrophobicity to the keratinous substrates, including hair, and increased hold to the shape or configuration of the keratinous substrate, upon application thereto. It is in particular a hair treatment composition and process for enhancing durable non-permanent shaping and curling of the hair.

Abstract: Compositions including polycarbodiimide together with a cationic polymer to enhance the quality of the keratinous substrates. Treatment compositions and processes related thereto for treating keratinous materials, in particular for hair-styling, where, according to the process, the polycarbodiimide and cationic polymer actives may be applied in a treatment that is a single step emulsion or at least two sequential steps. The composition includes 2.0 to 4.0%, by weight, of the composition of a combined amount of the polycarbodiimide and the cationic polymer in amounts sufficient to impart hydrophobicity to keratinous substrates, including hair fibers, upon application thereto.

Abstract: Compositions including polycarbodiimide together with a cationic polymer to enhance the quality of the keratinous substrates. Treatment compositions and processes related thereto for treating keratinous materials, in particular for hair-styling, where, according to the process, the polycarbodiimide and cationic polymer actives may be applied in a treatment that is a single step emulsion or at least two sequential steps. The composition a combined amount of the polycarbodiimide and the cationic polymer in amounts sufficient to impart hydrophobicity to keratinous substrates, including hair fibers, upon application thereto. It is in particular a hair treatment composition and process for providing improved shaping performance and shape memory for durable non-permanent shaping, straightening, and curling of the hair, particularly under conditions of one or more of high heat and high humidity by stiffening the hair through crosslinking, thereby retaining the style properties of the hair.

Abstract: Treatment compositions including a polycarbodiimide together with a carboxysilicone polymer to enhance the quality of keratinous substrates. Treatment compositions and processes related thereto for treating keratinous substrates, in particular for hair-care, where, according to the process, the polycarbodiimide and carboxysilicone polymer actives may be applied in a treatment that is a single step emulsion or at least two sequential steps. The composition includes 0.1 to 40.0%, by weight, of the composition of a combined amount of the polycarbodiimide and the carboxysilicone polymer in amounts sufficient to impart hydrophobicity to keratinous substrates, including hair fibers, upon application thereto. It is in particular a treatment composition and process for imparting lasting protection and for improving damaged hair by enhancing the hair's hydrophobicity, thereby enhancing retention of curl, making the make hair easier to comb, and improving the feel thereof.

Abstract: The present invention refers to an aqueous colorant composition comprising poly(lactic acid) (PLA) and a colorant. The invention also refers to the uses of said composition particularly in methods for coloring hair.

Abstract: Compositions including polycarbodiimide together with latex compounds to enhance the quality of the keratinous substrates. The present invention relates to a cosmetic treatment and process for treating keratinous materials, in particular for nail polishes and other treatments, where, according to the process, the polycarbodiimide and latex actives may be applied in a nail treatment that is a single step or at least two sequential steps. The ratio of the latex compound to the polycarbodiimide compound is in the range from about 50:50 to about 95:5, and the composition comprises 10 to 100% of a combined amount of the polycarbodiimide compound and the latex compound, by weight, of the entire composition. It is in particular a nail treatment composition and process for providing one or more of improved adhesion, water resistance, and shine through crosslinking between the actives, thereby imparting long wear, good shine, nail protection, and easy removal.

Abstract: Compositions including polycarbodiimide, and derivatives thereof, together with optional colorants, and amino compounds and derivatives thereof to enhance the quality of keratinous substrates are disclosed. The present invention relates to a cosmetic treatment and process for treating the keratinous substrates, in particular for hair coloration and treatment of artificially colored hair, wherein the composition can include the polycarbodiimide and the amino compound in amounts sufficient to impart one or more of improved color deposit, improved color retention and extended color durability.

Abstract: Compositions including polycarbodiimide and derivatives thereof together with latex polymers and derivatives thereof to enhance the quality of the keratinous substrates. The present invention relates to a cosmetic treatment and process for treating keratinous materials, in particular for hair-care and hair-styling. A method of styling or shaping hair is also disclosed.

Abstract: Treatment compositions including a polycarbodiimide together with a carboxysilicone polymer to enhance the quality of keratinous substrates. Treatment compositions and processes related thereto for treating keratinous substrates, in particular for hair-care, where, according to the process, the polycarbodiimide and carboxysilicone polymer actives may be applied in a treatment that is a single step emulsion or at least two sequential steps. The composition includes 0.5 to 40.0%, by weight, of the composition of a combined amount of the polycarbodiimide and the carboxysilicone polymer in amounts sufficient to impart hydrophobicity to keratinous substrates, including hair fibers, upon application thereto. It is in particular a treatment composition and process for imparting lasting protection and for improving damaged hair by enhancing the hair's hydrophobicity, thereby enhancing retention of curl, making the make hair easier to comb, and improving the feel thereof.

Abstract: The disclosure relates to systems and methods for improving the appearance of the skin. Systems comprise a skin-tightening composition comprising at least one thermoplastic elastomer, at least one adhesive polymer, and at least one filler, and a cosmetic composition comprising at least one colorant and optionally at least one volatile solvent. Methods comprise applying the compositions of the systems on to the skin.

Abstract: Novel hybrid coating compositions for mammalian nails, systems comprising the compositions, kits containing these compositions or systems, and methods of their use are disclosed. The novel compositions and/or kits are useful, inter alia, for providing durable, “soak-off” type nail coatings.

Abstract: The disclosure relates to compositions and methods for improving the appearance of the skin. Compositions comprise comprising (A) (a) at least one vinyl-terminated polysiloxane and at least one hydride-functionalized polysiloxane, and (b) at least one filler; and (B) (a) at least one vinyl-terminated polysiloxane; (b) at least one filler, and (c) at least one metal catalyst. Methods comprise applying the compositions to the skin to tighten the skin or hide skin imperfections by forming a film on the skin. Kits comprising the composition are also disclosed.

Abstract: A method for treating human or animal skin, hands, feet, hair or nails to eliminate or reduce the number of microorganisms thereon by topical application of an aqueous formulation comprising antimicrobial organosilane quaternary ammonium compounds and benzalkonium chloride of the quaternary group, which provides antimicrobial and antiseptic activity. The method prevents reinfection for at least 12, preferably 24 and most preferably at least 60 hours. The formulation may further comprise methyl anthranilate, which performs the dual functions of fragrance (grape fragrance) and biocidal agent. The formulation may further comprise other compatible inert but desirable ingredients such as moisturizers, color and fragrance.

Abstract: Compositions including polycarbodiimide and derivatives thereof together with f amino silicone compounds and derivatives thereof to enhance the quality of the keratinous substrates. The present invention relates to a cosmetic treatment and process for treating keratinous materials, in particular for hair-care and hair-styling, wherein the composition can include the polycarbodiimide and the amino silicone compound in amounts sufficient to impart hydrophobicity to keratinous substrates, including hair fibers, upon application thereto. It is in particular a hair treatment composition and process for enhancing durable non-permanent shaping and curling of the hair.

Abstract: The invention relates to systems and methods for improving the appearance of the skin. The systems comprise 1) a skin-tightening composition comprising (a) at least one film former; (b) at least one polyvalent silicate thickener; (c) at least one anionic associative polymeric thickener; (d) at least one plasticizer; and (e) optionally, at least one cosmetic powder, and 2) a long-wear cosmetic composition comprising at least one silicone-polyamide copolymer, at least one silicone film former, and at least one volatile oil. Methods comprise applying the compositions of the systems on to the skin sequentially after a drying period.

Abstract: The invention relates to systems and methods for improving the appearance of the skin. The systems comprise 1) a skin-tightening composition comprising at least one thermoplastic elastomer and at least one adhesive polymer; and 2) a long-wear cosmetic composition comprising at least one silicone-polyamide copolymer, at least one silicone film former, and at least one volatile oil. Methods comprise applying the compositions of the systems on to the skin sequentially after a drying period.

Abstract: The invention relates to a composition, especially a cosmetic composition, comprising at least one dispersion of film forming particles in aqueous phase and high levels of plant oil, as well as to methods of using such compositions.

Abstract: A sunscreen composition composed of all-natural ingredients comprising a wax, a natural oil and zinc oxide.

Abstract: The present invention is directed to a cosmetic composition comprising (a) an emulsifier selected from: (i) glyceryloleate citrate combined with a native oil as a viscosity modifier; or (ii) organogel comprising Helianthus Annuus (Sunflower) Seed Oil, Polyacrylic Acid, Xylityl Sesquicaprylate, Glyceryl Stearate, Euphorbia Cerifera (Candelilla) Wax, Sodium Hydroxide and Tocopherol; (b) at most 3 (three) emollient agents; (c) 01 (one) humectant and (d) cosmetically acceptable adjuvants. Furthermore, the present invention is directed to the use of the cosmetic composition according to the present invention as a moisturizing agent to be used on keratinic tissue, particularly skin, and to a method of moisturizing keratinic tissue, particularly skin, comprising applying the cosmetic composition according to the present invention onto said keratinic tissue, particularly skin.

Abstract: The present invention relates generally to methods and compositions useful to cleanse, exfoliate, smooth, moisturize, hydrate, and/or improve the appearance and/or condition of skin and/or hair using a composition including shea butter, PEG-50 shea butter, and/or hydrated silica.

Abstract: Topical compositions and methods of use of topical compositions including a four component system consisting of olive polyphenols, turmeric curcuminoids, cruciferous sulforaphane and green tea catechins to improve the appearance of aging skin and to prevent and treat skin aging. The compositions are applied to aging skin to improve the appearance of aging skin, including surface spots, brown spots, red areas, wrinkles and texture and other artifacts of aging skin, as well as conditions of skin dryness, dullness, loss of elasticity, lack of radiance, exaggerated lines and wrinkles, spider vessels or red blotchiness.

Abstract: The present invention relates to a composition, containing tyndallized lactobacillus dead cells as an active ingredient, for skin moisturizing or wrinkle improvement. The effect of the tyndallized lactobacillus dead cells on skin moisturizing and wrinkle improvement, which are deteriorated by ultraviolet radiation, was checked. As a result, it was confirmed that the amount of moisture evaporating from the skin was reduced and the amount of moisture contained in the skin was increased. In addition, it was confirmed that the epidermis thickness was reduced and the expression levels of wrinkle-related proteins were reduced. Therefore, the composition of the present invention improves the damage of the skin barriers, which is caused by ultraviolet radiation, thereby suppressing the loss of skin moisture or the wrinkle formation.

Abstract: A veterinary pharmaceutical composition, including at least one active veterinary pharmaceutical substance which is selected among gonadorelin and gonadorelin analogs as well as salts of gonadorelin and of the gonadorelin analogs, is provided. The composition includes a liposome-free matrix which delays the release of the active veterinary pharmaceutical substance from the composition, which matrix includes a basic material which is selected from the group consisting of natural and synthetic triglycerides, vegetable oils, diacylpropanediols, diacylbutanediols and mixtures of these substances, the veterinary pharmaceutical composition including no biodegradable polymer.

Abstract: The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.

Abstract: The present invention relates to cough syrups containing ambroxol hydrochloride, characterised in that they are substantially free from glycerol, and their use for mucolytic treatment in acute and chronic diseases of the bronchi and/or lungs.

Abstract: The present application relates to probiotic confection-based compositions comprising lactic acid-producing bacteria and oil-based compositions comprising the same.

Abstract: A drink for moderating blood glucose levels produced by a meal in a human subject suffering diabetes or impaired glucose tolerance (IGT) the drink comprising: at least one water soluble or water dispersible compound selected from the group consisting of amino acids, peptides and proteins in a total amount of at least 8g on a dry weight basis per serving of drink; aqueous liquid in an amount of from 70 ml to 400 ml (preferably in an amount of from 100 ml to 250 ml and more preferably from 125 ml to 175 ml) per serving, and wherein the drink exhibits shear banding when subject to the shear banding test herein described.

Abstract: An aqueous gel composition comprising a) water, at least one polysaccharide and at least one high molecular weight polyethylene oxide, wherein the water content is at least 90% by weight of the composition, and b) a local anaesthetic agent or an analgesic agent, for use as a local anaesthetic or analgesic. The aqueous gel shows transparency, lubricity, stringiness, elongation, extensiveness, and cohesiveness while being devoid of taste and smell and non-tacky or non-sticky.

Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

Abstract: Methods for determining dosage of HER2-targeted anthracycline-containing immunoliposomes are disclosed, as are methods of treating cancer patients with HER2-positive tumors using dosages so determined. Upon administration, the dosages share the low cardiotoxicity profile of standard dosages of non-immunoliposomal (untargeted), anthracycline-containing liposomes.

Abstract: The invention relates to a co-granule of xanthan gum and acacia gum having an average diameter of between 50 ?m and 1000 ?m.

Abstract: A solid oral dosage form is provided, comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a Tabletting aid with a low water content and to a process for the preparation thereof. The Tabletting aid composition is a directly compressible composition, the use of which results in improved tablet properties.

Abstract: An abuse deterrent immediate release biphasic matrix solid dosage form that releases the drug at a desired rate for quick onset of action when a single unit or prescribed units of the dosage form are orally administered but exhibits a reduced rate of release when more than the prescribed number of units, are administered.

Abstract: A solid oral dosage form includes a core comprising a non-ionic polymer matrix, a first amount of a first antiemetic drug or a pharmaceutically acceptable salt thereof dispersed within the matrix, and a salt dispersed within the matrix; a first seal coat of a non-ionic polymer matrix surrounding the core; and an immediate release drug layer surrounding the first seal coat, wherein the immediate release drug layer comprises a non-ionic polymer and a second amount of a second antiemetic drug or a pharmaceutically acceptable salt thereof dispersed therein, wherein the drug layer is sufficiently designed to release the second amount of the antiemetic drug over a period of at least 1 hour, wherein the solid oral dosage form is sufficiently designed to release the first amount of the first antiemetic drug and the second amount of the second antiemetic drug over a minimum period of 16 hours.

Abstract: Single oral solid dosage form comprising an immediate release first dosage composition having at least two antibiotic agents and a delayed release second dosage composition having a proton pump inhibitor are provided herein. The single oral solid dosage form according to some aspects of the invention can be used for the treatment of disorders associated with infection by H. pylori or the prevention of recurrence of disorders associated with infection by H. pylori.

Abstract: Compositions and methods are provided for administering a pharmaceutical composition to a human patient. Compositions are administered to a human patient orally, once daily, at a therapeutically effective dose. The pharmaceutical compositions comprise a drug selected from the group consisting of brivaracetam, divalproex, lacosamide, levetiracetam, oxcarbazepine, vigabatrin, and pharmaceutically acceptable salts of any of the foregoing, and at least one excipient. At least one of said at least one excipients modifies the release of said drug to provide an extended release form. The pharmaceutical composition have pharmacokinetic properties recited in the claims.

Abstract: The present disclosure relates to a tumor-targeted drug delivery system, comprising a tumor-targeted drug carrier and a tumor-treating drug, wherein the tumor-targeted drug carrier comprises full heavy-chain human ferritin. The present disclosure also relates to a method for preparing the tumor-targeted drug delivery system comprising: depolymerizing a polymerized full heavy-chain human ferritin; adding a tumor-treating drug to the depolymerized full heavy-chain human ferritin so as to bind the tumor-treating drug to the depolymerized full heavy-chain human ferritin; and re-polymerizing the depolymerized full heavy-chain human ferritin bound with the tumor-treating drug to form a nanoparticle.

Abstract: The present invention relates to nanocapsules which are stabilized by a bile acid or salt thereof. The nanocapsules comprise a polymeric shell formed by poly(alkyl cyanoacrylates) and/or alkoxy derivatives thereof, wherein the polymeric shell encapsulates a core comprising an active agent. The invention further relates to methods for preparing and compositions comprising such nanocapsules.

Abstract: The present invention relates to nanospheres comprising a polymeric matrix and antigen-binding molecules esterase-releasably incorporated therein. The polymeric matrix is formed by poly(alkyl cyanoacrylates) and/or alkoxy derivatives thereof. The invention further relates to methods for preparing and compositions comprising such nanospheres.

Abstract: The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the flow characteristics of the compositions and thereby reduce the problem of film adhering to a user's mouth or to other units of film. In particular, the present invention relates to edible water-soluble delivery systems in the form of a film composition including a water-soluble polymer, an active component selected from cosmetic agents, pharmaceutical agents, vitamins, bioactive agents and combinations thereof and at least one anti-tacking agent.

Abstract: Embodiments of the invention relate generally to the field of transdermal delivery and more specifically to transdermal patches containing rasagiline for the treatment of depression, Parkinson's disease, and other nervous system conditions.

Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.

Abstract: A system and method includes delivery of a redox gas solution to treat onychomycosis, wherein the redox gas solution comprises a reactive species dissolved in a perfluorocarbon liquid, and wherein the reactive species may include, alone or in combination, one or more of reactive oxygen, reactive nitrogen, reactive chlorine, or reactive bromine species, and the perfluorocarbon liquid may include perfluorodecalin.

Abstract: The invention provides methods and compositions for treatment of a subject with a glioma that has failed treatment with temozolomide (TMZ) comprising administration of a composition comprising a Coenzyme Q10 compound to the subject. The invention also provides a method of treating a cancer that exhibits increased Complex II activity in a subject comprising administration of a composition comprising a Coenzyme Q10 compound to the subject.

Abstract: This disclosure provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units, wherein said capsule dosage form is bioequivalent to the marketed Toprol-XL® tablet. The extended-release capsule dosage form comprising coated discrete units can be sprinkled onto food to ease administration to patients who have difficulty swallowing tablets or capsules.

Abstract: Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an active agent, a pH raising agent, an antioxidant, a transition metal complexing agent, a pH lowering agent, a tonicity regulating agent, optionally a preservative, and optionally a solvent.

Abstract: S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the standard daily dosage.