Abstract: A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ) equipped with an embedded dichroic mirror. A probe tip that uses a clad fiber to supply light to a focusing element provides enhanced OCT and AF performance.

Abstract: A probe (1) is used in an optical coherence tomography device which irradiates measurement light to a subject and collects scattered light that has returned from the subject after being reflected. The probe (1) is provided with a scanning means (70) composed of galvanometer mirrors (72, 73) that change an irradiation direction of the measurement light. The scanning means (70) is provided with actuators (72b, 73b) which switch reflecting mirrors (72a, 73a) that reflect the measurement light between a state where the measurement light is reflected by the subject and returns as the scattered light, and a state where the measurement light is diffusely reflected within the probe (1).

Abstract: An object information acquiring apparatus, comprising: a plurality of detecting elements which detect an acoustic wave generated from an object irradiated with light and convert the acoustic wave into detection signals; a signal determining unit which determines a detection signal detected by a detecting element which is not in acoustic contact with the object, of the plurality of detecting elements; a signal acquisition unit which generates a corrected detection signal by deleting at least a region which is not based on an acoustic wave generated from the interior of the object, from the determined detection signal; and an image processor which forms image data of the object from a detection signal detected by a detecting element which is in acoustic contact with the object and from the corrected detection signal.

Abstract: An insertion needle has a light guide member for guiding light emitted from a light source, a light emitting portion for emitting light guided by the light guide member, and a photoacoustic wave generating portion for generating photoacoustic waves caused by light emitted from the light emitting portion. A photoacoustic image generation unit generates a photoacoustic image based on the detection signal of the photoacoustic waves. A distal end candidate extraction unit extracts a distal end candidate region from the shallow side of the image based on the strength of the detection signal of the photoacoustic waves. An image output unit displays the extracted distal end candidate region on an image display unit.

Abstract: A probe having a sensor configured to be attached to a living body to detect a physiological parameter and an information element configured to identify the sensor is connected to an interface of a physiological parameter processing apparatus. A detecting section of the physiological parameter processing apparatus detects, through the interface, whether the information element is present and whether the sensor is present. In response to the information element being detected but the sensor not being detected, a limiting processor of the physiological parameter processing apparatus limits at least a part of a function of the information element.

Abstract: A non-invasive electronic patient monitor tracks one or more physiological parameters of a patient, such as intravascular volume index (IVI), extravascular volume index (EVI), total hemoglobin (SpHb), impedance, and/or weight. The patient monitor determines if one or more of the physiological parameters are within a predetermined range. The patient monitor activates an alarm if one or more of the physiological parameters are outside the predetermined range and indicates a patient can be experiencing edema and/or heart failure, or sepsis.

Abstract: An ultrasonic diagnostic imaging system is described which utilizes one or more transducer arrays affixed to the head of a patient to diagnose and treat stroke victims. The transducer headset produces a two or three dimensional image of the vasculature inside the cranium, preferably assisted by a microbubble contrast agent. A vascular flow map is produced by the system which may be diagnosed for signs of a blood clot. If a blood clot is detected, a therapeutic beam is transmitted while the contrast agent is present to break up the blood clot by the disruption of microbubbles. The headset may also be used in a monitoring application to detect the recurrence of blood clots in a stroke victim.

Abstract: A physiological status monitoring device includes a monitoring module and a fixing module. The monitoring module includes a first housing configured to be arranged at a first side of a flexible object, a monitoring unit arranged in the first housing for monitoring a physiological status of a human body, a first processing unit electrically connected to the monitoring unit for controlling operations of the monitoring unit, and a first magnetic fixing unit connected to the first housing. The fixing module includes a second housing configured to be arranged at a second side of the flexible object, and a second magnetic fixing unit connected to the second housing. Wherein, the first magnetic fixing unit and the second magnetic fixing unit are configured to hold the first housing and the second housing on the flexible object by magnetic force.

Abstract: A biological information measuring device according to an aspect of the present disclosure includes: a light source that, in operation, emits irradiation light for irradiating a test portion of a subject; a light detector that, in operation, detects light from the subject and outputs an electrical signal corresponding to the light; and a control circuit that, in operation, determines a power of the irradiation light emitted by the light source, and that, in operation, measures biological information related to a blood flow at the test portion based on the electrical signal. The control circuit, in operation, detects a distance between the light source and the test portion based on the electrical signal, and determines the power of the irradiation light such that the power of the irradiation light is increased as the distance increases.

Abstract: An apparatus for an accurate automated non-invasive measurement of blood pressure waveform using brachial (occlusion) cuff pressurized above systolic pressure and using differential pressure sensor. The methodology involves measurement in suprasystolic mode and in utilization and construction of the device followed by algorithms for processing and analysis of measured blood pressure pulse waves and assessment of hemodynamic parameters of human cardiovascular system. The device includes an electro-pump connected to the collar device, a differential pressure sensor, pressure senor A, pressure sensor B, valve, closing a valve and the air reservoir. The cuff is wrapped around a person's arm. The values of the instantaneous pressure in the pneumatic portion of the device are converted into an electric signal by the pressure sensor A, pressure sensor B and the differential pressure sensor.

Abstract: A blood pressure detection method includes the steps of: acquiring a PPG signal from a skin surface using a light sensing element; calculating a blood pressure corresponding to each pulse duration according to at least one pressure estimation model and a time difference between two feature points within one pulse duration; calculating a breathing period; averaging a plurality of blood pressures within the breathing period to generate an average blood pressure; and showing the average blood pressure with a display device.

Abstract: A method of determining blood pressure measurements includes inflating a cuff, receiving an indication of pressure inside the cuff during inflation, determining a blood pressure based at least in part on the received indication, assigning a confidence level to the blood pressure, and determining whether the confidence level satisfies a threshold confidence level. Based at least on a determination that the confidence level satisfies a threshold confidence level, the method can include causing a display to display the blood pressure. Based at least on a determination that the confidence level does not satisfy a threshold confidence level, the method can include deflating the cuff, receiving an indication of pressure inside the cuff during deflation, determining another blood pressure, and causing a display to display a blood pressure.

Abstract: A sensor that is capable of detecting a pulse of a user by using a proximity illumination sensor or a proximity sensor is provided. A proximity sensor (14) that includes a pulse detection function includes a count adjustment circuit (5) that performs adjustment such that a digital output value (ADCOUT1) from an analog-digital conversion circuit (4) changes in accordance with each value of a distance at least in a prescribed range of the distance between a photodiode (2) and a detected object (a finger in the drawing) and a digital filter (6) for detecting a cycle of the digital output value (ADCOUT1) from the analog-digital conversion circuit (4).

Abstract: A system and method for secure physiological data processing and delivery are provided. A log of identifiers of physiological monitoring patches and of passwords is maintained in a secure database. Physiological monitoring data obtained using one of the patches is received by at least one server together with the identifier and the password associated with that patch. The received identifier and password are compared with the identifiers and passwords stored in the log. The received physiological monitoring data is stored in electronic medical records associated with the matching identifier. The password and the identifier associated with the physiological monitoring data are received from a user device over the data communications network. The received password and identifier are compared to the password and the identifier associated with the electrical medical records. The electronic medical records are provided by to the user device over the data communication network based on the comparison.

Abstract: Described are systems, devices, and methods for deriving quantitative metrics of heart condition and function from one or more electrocardiograms or time-frequency maps derived therefrom. In various embodiments, repolarization indices for the left and right ventricles are determined from the T wave in respective electrocardiograms. An overall heart-health index may be determined based on a comparison between the left and right ventricular repolarization indices.

Abstract: The present disclosure pertains to a system configured to adjust an intensity of sensory stimulation delivered to a subject during a sleep session based on sleep spindles in the subject during the sleep session. The system is configured to adjust the intensity of the stimulation based on a sleep spindle frequency and/or a sleep spindle density. The system is configured to determine a recent spindle density and/or a recent spindle frequency for a recent period of time during the sleep session based on detected sleep spindles, and to determine a previous spindle density and/or a previous spindle frequency for a previous period of time during the sleep session based on the detected sleep spindles. The system controls the intensity of sensory stimulation provided to the subject based on a comparison of the previous spindle density to the recent spindle density and/or the previous spindle frequency to the recent spindle frequency.

Abstract: In order to reduce inaccuracy of a hemodynamic visualization image acquired when a blood flow is labeled before blood flow visualization imaging, an MRI apparatus uses a blood flow velocity to control pulse sequences including a sequence of applying a high-frequency pulse for labeling the blood flow and imaging the subsequent blood flow or display of the hemodynamic visualization image. For example, the blood flow velocity is used for controlling application positions of one or more high-frequency pulses from among a plurality of the high-frequency pulses for labeling. The MRI apparatus controls time between labeling the blood flow and starting imaging and/or the application positions of high-frequency pulses for labeling the blood flow. A threshold value for color display of a blood flow visualization image is controlled.

Abstract: Devices, systems, and methods for removing targeted lesions from vessels. In at least one embodiment of a device for removing a stenotic lesion from a vessel, the device comprises a sizing portion capable of measuring a luminal size parameter when at least part of the device is positioned within a lumen of a luminal organ, a typing portion, wherein at least part of the at least one typing portion is capable of physically touching a portion of the luminal organ or a structure therein, and a treatment portion capable of removing at least part of a stenotic lesion from the luminal organ.

Abstract: The present disclosure provides a mounting assembly for attaching medical equipment to a patient table. In one particular embodiment, the present disclosure provides a mounting assembly for attaching a magnetic field generator to a patient table. The mounting assembly allows for the secure attachment of the magnetic field generator to the patient table while also allowing for easy adjustment of the positioning and location of the magnetic field generator, even after the patient is on the table. In many embodiments the mounting assembly is comprised of a mounting apparatus that attaches directly to the patient table and first and second side rails that attach to the magnetic field generator and are configured to slidably attach to the mounting apparatus. In some embodiments, the mounting apparatus and side rails are constructed of a material that provides little or no interference with the magnetic field generator.

Abstract: Tubes (e.g., catheters, endotracheal or chest tubes and bypass grafts) are provided, comprising a catheter and a plurality of sensors. Briefly stated, a wide variety of tubes (e.g., catheters, endotracheal or chest tubes, bypass grafts, balloon catheters, urinary catheters, central lines and dialysis catheters), as well as related delivery devices (e.g., guidewires) are provided with a number of sensors to monitor the integrity, patency and efficaciousness of the device.

Abstract: A medical device, system, and method having a flexible shaft and a multi-core fiber within the flexible shaft. The multi-core fiber includes a plurality of optical cores dedicated for shape sensing sensors, and a plurality of optical cores dedicated for force sensing sensors. A medical device flexing structure assembly can comprise a multi-core fiber comprising a plurality of cores, and a flexing structure comprising at least one slot. Each of the plurality of cores can comprise a fiber Bragg grating, and the flexing structure can be configured to bend in response to a force imparted on the flexing structure.

Abstract: A wearable antenna for communicating between an external transceiver and a capsule inside the gastrointestinal tract of a user, including a printed circuit board for forming a conducting pattern on a first face and on a second face of the printed circuit board; a first conducting pattern on the first face of the printed circuit board, including: a) an almost completely split conducting elongated bar across a center of the printed circuit board; b) an identical main conducting transmission area on each side of the almost completely split elongated bar; c) a thin conducting line respectively connecting between each side of the almost completely split elongated bar and the transmission area; a second conducting pattern on the second face of the printed circuit board including a U shaped conductor; wherein the U shaped conductor is positioned to serve as a balun for the conducting pattern on the first face.

Abstract: The invention generally relates to systems and methods for determining a concentration of glucose in exhaled breadth. In certain aspects, the invention provides a system including a sample collection module configured to collect a condensate sample produced from a mixture of exhaled breadth from a subject and ambient air. The condensate sample includes exhaled breadth glucose and ambient air glucose. The system also includes an assay module configured to assay the condensate sample for total glucose. The system also includes an analysis module that includes a processor that is configured to determine a total glucose concentration in the condensate sample, and adjust the total glucose concentration based upon a concentration of the ambient air glucose in the condensate sample, thereby determining a concentration of the exhaled breadth glucose in the exhaled breadth from the subject.

Abstract: A rehabilitation assistance system includes: a first display apparatus which is to be attached to a head of a patient, and which enables a body portion of the patient to be seen; and a display controller which causes an index image that functions as an index for a rehabilitation motion, to be displayed on the first display apparatus.

Abstract: A risk-of-falling determination apparatus includes a walk information obtainer that obtains walk information of a user, a myoelectric sensor that measures a first myoelectric potential difference on an anterior surface of a thigh of the user and a second myoelectric potential difference on a posterior surface of the thigh, a control circuit that identifies an interval of a stance phase by using the walk information, calculates a degree of co-contraction at a corresponding leg of the user on the basis of the first and second myoelectric potential differences for the stance phase, and determines whether the degree of co-contraction is greater than or equal to a first threshold, and an outputter that outputs a signal indicating that the user has a high risk of falling if the degree of co-contraction is greater than or equal to the first threshold.

Abstract: New activity recognition, recording, analysis and control techniques, systems and sensors are provided. In some aspects of the invention, multiple sensory tags with unique identification and data transfer attributes, create positional, movement, orientation and acceleration data and supply it to a control system. The tags may be placed at location(s) on the user's body, clothing, personal effects, exercise equipment and other activity-relevant locations, to enhance activity recognition and mapping. For example, a specialized PDA may comprise part of the control system, and may provide, reflect and/or receive modified data signals to and from such tags. In other aspects, a system defines a personal activity space, samples data preferentially from that space, and performs a simplified form of object-recognition to determine, record and analyze personal activities. A GUI interface within the control system may also aid in recognizing and recording activity patterns, in addition to tags.

Abstract: A method, system, and computer-readable medium receive module configuration settings to configure a customized human movement examination module for a human movement examination item. A patient is instructed with audio instructions associated with the customized human movement examination module. A single camera is controlled having progressive scan capabilities according to the module configuration settings to allow recording of a performance by the patient of the human movement examination item. The recorded data is analyzed based on the information provided by the single camera to measure human movement exhibited by the patient.

Abstract: The invention is a device and method for measuring, inter alia, blood oxygenation, arterial/venous blood gas, and/or hemoglobin values in an already-inserted arterial or venous catheter in a patient. It allows the measurement of a meaningful and commonly understood metrics of blood oxygenation and gas exchange in hypo-perfused patients while avoiding the additional discomfort and risk of infection posed by inserting a standalone device with its own catheter. Analogous uses of the apparatus for other measurements is possible.

Abstract: Provided are dermal sensors and dermal sensor applicator sets to insert at least a portion of a dermal sensor into a dermal layer of a subject, as well as methods of making and using the same.

Abstract: Devices, systems and methods for measuring, and configured to measure, a blood analyte continuously or at intervals, the device comprising at least a first set of analyte sensing sensor electrodes configured for making electrochemical measurements of the analyte, and at least a second set of biofouling prevention electrodes in operable proximity to, and configured to prevent biofouling of, the first set of electrodes.

Abstract: It is commonly known within the art of cutaneous/transcutaneous blood gas monitoring to warm up the skin of the patient to allow carbon dioxide and oxygen to diffuse easily through the skin. This is especially the case for transcutaneous partial pressure monitoring of oxygen. Heating the skin to 43° C. to 45° C. over several hours or days may cause damage to the skin. In order to avoid or minimize the risk of these damage, it is proposed to monitor the blood gases at a lower temperature with a cutaneous sensor, and intermittently warm up the skin to a temperature of 42° C. or more for a short duration to monitor the transcutaneous partial pressure of oxygen, before lowering the temperature to the lower set point.

Abstract: The present technology relates to a detection device, a detection method, and a program capable of detecting a living body state of a human body easily and accurately. A contact lens type display device is provided with a tear detection unit 26 to collect tears on an eyeball and to analyze a constituent and detect affective information of a user. The detection result is sent from the contact lens type display device 11 to a mobile terminal SP and displayed on the mobile terminal SP. Consequently, the living body state can be detected on the basis of the constituent of the tears of the user, whereby the living body state of the user can be accurately detected. The present technology can be applied to a contact lens type display unit.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the interaction of the target analytes with the functionalized particles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.

Abstract: A device includes a sensor for measuring a parameter for tissue. The sensor includes a plurality of optical elements including a plurality of detectors and at least one emitter. Separation distances between the various optical elements are selected based on a depth corresponding to a region of interest in the tissue and based on a depth corresponding to an exclusion region in the tissue.

Abstract: The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.

Abstract: A food taste simulation method, applied in a food taste simulation system, comprising: determining food information of target food according to a food simulation trigger signal when receiving the food simulation trigger signal; determining airflow for simulating the taste of the target food according to the food information; and releasing the airflow through an airflow chip disposed in the oral cavity according to the airflow. The safety of food simulation is improved and the effect of food simulation is enriched in this method. A food taste simulation system is also provided.

Abstract: A device can include a body having a top surface, an opposing bottom surface, a first face and an opposing second face. The first face can have an opening therein. A light source can be positioned within the body. The light source can be configured to create a beam of polarized light. At least a portion of the beam of polarized light can be directed outside of the body through the opening in the front face. At least one polarization sensitive detector can be positioned within the body. At least one light can be positioned on or in the first face. At least one target can be configured to be visible through the opening in the front face of the device. The lights and the target can be configured to illuminate in a predetermined manner or pattern.

Abstract: A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a processing unit. The processing unit has a processor and memory with instructions for classifying data from the plurality of sensors to determine probability of the patient being ictal, when the probability is high asking the patient if the patient is in an ictal state, reporting to a caregivers if the patient is ictal, and updating the classifier based upon sensor data, probability, and the response. The method includes sensing, using a plurality of non-electroencephalographic sensors, determining, using a classifier trained using a training dataset, probability of the patient being in an ictal state, and if probability is high, asking the patient if the patient is in ictal state, logging the occurrence of an ictal state, and updating the classifier.

Abstract: Methods and items useful at least therein are provided for IBS related testing and treatment. Disclosed is a patch useful in determining if one or more test materials can cause allergic contact dermatitis in a patient. A kit containing information on use and that may include such a patch and/or test material(s) is also disclosed. A method of IBS related testing including performing skin patch testing on a patient presenting IBS symptoms using at least one test material that can cause allergic contact dermatitis is provided. A method for the treatment of IBS which includes limiting the intake by a patient presenting IBS symptoms of at least one material that gives a positive skin patch test result in the patient is also disclosed.

Abstract: Orthopedic device or implants are provided, comprising an orthopedic device or implant and a sensor.

Abstract: A method and system of determining a sleep stage of a user involves receiving a respiratory flow signal of a user, obtaining at least one respiratory feature from at least part of the respiratory flow signal, and determining a sleep stage from the at least one respiratory feature.

Abstract: A patient monitor for monitoring cerebral activity of a patient may include a processor configured to determine a depth of consciousness index for the patient based on electroencephalography (EEG) data and determine regional oxygen saturation for the patient based on regional oximetry data. Additionally, the processor may be configured to determine a metric associated with cerebral activity of the patient based at least in part on the one or more values of the depth of consciousness index and the one or more regional oxygen saturation values and to provide the one or more values of a depth of consciousness index and the metric to an output device.

Abstract: Monitoring patient compliance with a compression therapy regimen. Venous Refill Time (VRT) is monitored via a pressure sensor in a bladder of a compression system. A controller of the compression system correlates the monitored VRT to a predetermined threshold to determine whether the patient is using the compression system.

Abstract: Disclosed is a method for interacting with the nervous system. The method includes detecting signals associated with a biological function at one or more sensors. It also includes processing the signals to create a representation thereof, delivering effector responses based on the representations, and controlling a physical process.

Abstract: A self-administered tamper-evident drug detection system. The system includes a biometric detection surface for each of a user's right and left hands, configured to identify the user and prevent tamper by continuously capturing biometric information from each of the user's right and left hands while the system is administering a drug detection test. The system further includes a collection device to administer the drug detection test by exposing a sample collection device to a user's mouth to collect a saliva sample.

Abstract: A purpose-made predictive instrument for the administration of cardiac metabolic support for acute coronary syndromes (ACS, which include unstable angina and acute myocardial infarction) that particularly identifies those most likely to benefit from treatment. In some examples, such a predictive instrument is used for real-time decision support for the administration of treatments such as glucoseinsulin-potassium (GIK).

Abstract: A system and method for allowing any surgeon, including those surgeons who perform a fewer number of a replacement procedure as compared to a more experienced surgeon who performs a greater number of procedures, to provide an improved likelihood of a favorable outcome approaching, if not exceeding, a likelihood of a favorable outcome as performed by a very experienced surgeon with the replacement procedure. Force sensing is included to aid in quantifying installation of an implant, particularly a cup into a pelvic bone.

Abstract: A joint monitoring system for measuring performance parameters associated with an orthopedic articular joint comprises a force sensing module and an inertial measurement units. The sensing module comprises a housing that engages with the joint articular surface having a medial portion and a lateral portion. The sensing module also includes a first and second set of sensors disposed within the housing. The first set of sensors are mechanically coupled to the medial portion of the particular surface and configured to detect information of a force incident upon the medial portion of the articular surface. The second set of sensors are mechanically coupled to the lateral portion of the articular surface and configured to detect information a force incident upon a lateral portion of the articular surface. The inertial measurement unit is configured to detect an orientation of at least one of a first and second bone of a knee joint.

Abstract: Spinal device/implants are provided, comprising a spinal device/implant and a sensor.