Abstract: An exoskeleton includes first and second compression members configured to be coupled to a wearer of the exoskeleton. A tensegrity joint connects the first compression member to the second compression member, the joint including a tensile member having a first end and a second end. The first end is coupled to the first compression member on a first side of the joint, and the second end is coupled to the first compression member on a second side of the joint opposite the first side.

Abstract: A walker device for assisting a user while walking or engaging in exercise on various types of terrain. The walker device includes a frame having a front and rear end. A front fork extends from the front end of the frame and a pair of parallel rear forks extend from the rear end. A wheel is each rotatably secured to the front fork and the rear forks. A handle is adjustably disposed on each of the pair of rear forks via a track so as to allow a user to adjust the height of each handle. The frame is disposed along a single plane and can support a substantial portion of a user's weight, such that the user may be assisted while walking along an unleveled terrain. In some embodiments, a container and firearm bracket are mountable to the frame so the walker device can be used when hunting.

Abstract: Compression garments and methods may include a head garment configured to be positioned around both sides of a head of a body from a posterior of the head to an anterior of the head and a torso garment. Such garment portions may include one or more controllable pressure applying regions to move lymph from the head downward to the torso.

Abstract: The headache mitigating apparatus includes at least a transverse strap configured to wrap around a user's head in the manner of a hat band and at least one strap configured to extend under the user's occipital bone and rest along the user's upper neck as well as extending over the head strap at a forward end thereof. The apparatus can include bladders in the transverse and occipital straps, respectively. The bladders can be filled simultaneously or separately with a pneumatic hand pump such as those found on sphygmomanometers or may include an inflation apparatus which is operable via a push button, in a manner similar to that in which self-inflating items inflate. At least one strap may also accommodate a gel pack for heating or cooling. One or both straps may include buckles or hook and loop closures configured to be adjusted to secure the apparatus to the user's head.

Abstract: The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.

Abstract: A physiological state feedback system includes a physiological state detecting device, an electric massage device and a portable processing device. The physiological state detecting device is worn on a user, and detects to output a physiological information signal according to a state of the user. The electric massage device outputs a device motion signal. The portable processing device receives the physiological information signal and the device motion signal via wireless transmission technology to produce a feedback signal.

Abstract: The apparatus is configured for applying chest compressions to a patient to apply CPR. The apparatus includes a housing configured to mount the apparatus to the patient, a unidirectional motor, and a plunger connected to the unidirectional motor, the plunger configured to apply the chest compressions to the patient when the motor is operated. The apparatus may include a device configured to control a compression distance of compressions, The apparatus is simpler, lighter and eliminates complicated motor control required in prior devices.

Abstract: A spa can include one or more variable features or functions that can be controlled by a user using a gesture recognition sensor. The gesture recognition sensor can be located proximate to the spa and optionally out of the normal range of motion of a user in a basin of the spa. Predetermined gestures detected by gesture recognition sensor can be interpreted as a command to alter a predetermined feature or function of the spa. Also disclosed is a method of controlling one or more variable features or functions of the spa using the gesture recognition sensor.

Abstract: Systems and methods for providing network connectivity and remote monitoring, optimization, and control of pool/spa equipment are provided. “Internet-of-Things” (IoT) functionality is provided for pool and spa equipment in a flexible and cost-effective manner. Network connectivity and remote monitoring/control of pool and spa equipment is provided by various components such as a network communication and local control subsystem installed in pool/spa equipment, and other components. Also disclosed are various control processes (“pool logic”) which can be embodied as software code installed in any of the various embodiments of the present disclosure.

Abstract: Systems and methods for providing network connectivity and remote monitoring, optimization, and control of pool/spa equipment are provided. “Internet-of-Things” (IoT) functionality is provided for pool and spa equipment in a flexible and cost-effective manner. Network connectivity and remote monitoring/control of pool and spa equipment is provided by various components such as a network communication and local control subsystem installed in pool/spa equipment, and other components. Also disclosed are various control processes (“pool logic”) which can be embodied as software code installed in any of the various embodiments of the present disclosure.

Abstract: Systems and methods for providing network connectivity and remote monitoring, optimization, and control of pool/spa equipment are provided. “Internet-of-Things” (IoT) functionality is provided for pool and spa equipment in a flexible and cost-effective manner. Network connectivity and remote monitoring/control of pool and spa equipment is provided by various components such as a network communication and local control subsystem installed in pool/spa equipment, and other components. Also disclosed are various control processes (“pool logic”) which can be embodied as software code installed in any of the various embodiments of the present disclosure.

Abstract: Systems and methods for providing network connectivity and remote monitoring, optimization, and control of pool/spa equipment are provided. “Internet-of-Things” (IoT) functionality is provided for pool and spa equipment in a flexible and cost-effective manner. Network connectivity and remote monitoring/control of pool and spa equipment is provided by various components such as a network communication and local control subsystem installed in pool/spa equipment, and other components. Also disclosed are various control processes (“pool logic”) which can be embodied as software code installed in any of the various embodiments of the present disclosure.

Abstract: This invention provides a PTP sheet for pharmaceutical drug packaging from which a solid pharmaceutical drug is easily taken out and in which a pocket portion is hard to be accidentally damaged. A PTP sheet has a first sheet from which a pocket portion capable of housing a solid pharmaceutical drug protrudes to the side of an upper surface and a second sheet which is stuck to a lower surface of the first sheet and which closes an opening of the pocket portion. The pocket portion has a peripheral wall portion having a peripheral surface continuous with the upper surface and a top portion having a top surface continuous with the peripheral surface of the peripheral wall portion. A wall thickness of the peripheral wall portion is smaller than a wall thickness of the top portion.

Abstract: A drug dispenser assembly comprising: a drug dispenser for dispensing a drug in a dispense event; and a skinprint analyser configured to receive a skinprint, preferably a fingerprint, of a user. The skinprint analyser is further configured: to perform a verification test regarding the identity of the skinprint; to conduct a chemical analysis for the presence of a metabolite in the skin-print; and to produce data indicative of results of the verification test and the chemical analysis. The drug dispenser assembly further comprises an actuator configured to actuate a dispense event in the event that the results of one or both of the verification test and the chemical analysis meet one or more predetermined conditions.

Abstract: Adapters for a connector assembly for percutaneous tubing are provided. A male adapter (FIG. 22a, 1000) includes a connector fitting (1002) proximate a first end, the connector fitting configured to join to a connector for a tubing system or device, and a male connector (656) proximate a second end. The male connector includes a plug end with a fluid lumen defined therethrough, the plug end having a circumferential groove defined therein to receive a locking extension of a female connector sized to be received within the circumferential groove of the plug end to allow the female connector to rotate relative to and maintain axial engagement with the male connector when the locking extension is received within the groove. An adapter having a female connector (FIG. 24, 1300) is also provided.

Abstract: An object of the present invention is to provide a dental material, particularly, a dental prosthesis, having excellent properties such as hydrophilicity and antifouling properties. The dental prosthesis according to the present invention includes a monolayer film obtained by curing a composition including: a compound (I) having at least one hydrophilic group selected from anionic hydrophilic groups and cationic hydrophilic groups, and at least one functional group with a polymerizable carbon-carbon double bond; a compound (II) having two or more functional groups with a polymerizable carbon-carbon double bond (wherein the compound (II) has no anionic hydrophilic group nor cationic hydrophilic group); and a surfactant (III) having a hydrophilic moiety including an anionic hydrophilic group, a cationic hydrophilic group or two or more hydroxyl groups, and a hydrophobic moiety composed of an organic residue (wherein the surfactant has no polymerizable carbon-carbon double bond).

Abstract: What is described is a shaped cellulose body having physiologically active mineral substance compounds distributed therein, which are bound within the cellulose matrix of the shaped body and are distributed homogeneously over the cross section thereof. The mineral substance compound is soluble in water, and contains at least one element selected from the group comprising sodium, potassium, magnesium, calcium, iron, copper, manganese and zinc. Even after repeated washing, the shaped cellulose body still contains a high proportion of the mineral substance. It preferably takes the form of fibers, filaments, films or spunbonded webs formed from these fibers. It is especially intended for topical purposes on the human skin, specifically for cosmetic or dermatological purposes. These shaped bodies can be processed to give sheetlike structures, laminates, composite materials and webs, alone or in a mixture with other shaped bodies and fibers.

Abstract: The present invention relates to a process for preparing an antimicrobial particulate composition. The invention also relates to personal care or hygiene composition comprising an antimicrobial particulate composition obtainable by the process in accordance with this invention. The invention more particularly relates to a process for preparing an antimicrobial metal nanoparticles immobilized in an inorganic porous material and also incorporating these particles in personal care or hygiene compositions. The antimicrobial particulate composition comprises 0.05% to 3% by weight of antimicrobial metal particles and 97 to 99.95% by weight of immobilizer comprising an inorganic porous material selected from zinc oxide, magnesium hydroxide or calcium carbonate.

Abstract: The present disclosure provides biophotonic compositions containing halogen ions and/or halogen salts and methods useful in phototherapy. In particular, the biophotonic compositions comprising halogen of the present disclosure include at least one chromophore; and halogens and/or halogen salts such KI, or KCl, or KBr, or CsBr, or MgBr2, or ZnBr2, or NaF, or NaCl, or NaBr, or I2, or I3?, or Br2, or Cl2. The biophotonic compositions and the methods of the present disclosure are useful for promoting tissue repair, wound healing, bone regeneration and skin rejuvenation, as well as treating oral diseases, microbial and viral infections, acne and various other skin disorders and various orphan diseases.

Abstract: Topical skin care composition for night use containing a combination of stabilized anti-oxidants, oat derived avenanthramides, retinol-like compounds and biofunctional peptides and other optional ingredients for topical application for the treatment and prevention of skin damage due to environmental factors.

Abstract: The ingredient comprises a mixture of unsaturated dicarboxylic acids comprising the Z and E isomers of at least one mono-unsaturated dicarboxylic C12-C24 acid, the concentration of the E isomer being of at least 25% by weight based on the total weight of Z and E isomers. The ingredient can be used to form cosmetic or dermatological compositions, in particular for lightening the skin, improving the clarity and unification of the skin complexion.

Abstract: Using a curable resin composition including the following (A) to (E) configurations, which is excellent in adhesiveness to nails and curing reactivity, and a cured product of which has a certain flexibility, makes it possible to form a coating aiming for protection, decoration, and the like of nails with favorable followability to the nails: (A) 100 parts by mass of a compound having a urethane structure in molecule and containing acrylic functional groups at both terminals of a molecular chain, (B) 1 to 35 parts by mass of a trifunctional acrylic functional compound of a specific structure, (C) 15 to 75 parts by mass of a compound containing an acrylic functional group having an aliphatic ring structure, (D) 1 to 35 parts by mass of a compound containing an acrylic functional group having an aliphatic chain structure, and (E) 0.5 to 13.5 parts by mass of a photopolymerization initiator.

Abstract: A method for the permanent shaping and color modification of keratinic fibers, in a single process, includes the following method steps in sequence: deforming keratinic fibers, using deformation aids, applying an aqueous composition, including at least one keratin-reducing compound and at least one alkalizing agent, to the keratinic fibers situated on the deformation aids, and leaving this composition for a period of 5 to 50 minutes, rinsing the keratinic fibers situated on the deformation aids, applying a composition, including at least one oxidation dye precursor, at least one oxidizing agent, at least one alkalizing agent, and at least one surfactant, as foam from an applicator to the keratinic fibers situated on the deformation aids, and leaving this composition for a period of 10 to 45 minutes, removing the deformation aids from the keratinic fibers and rinsing the keratinic fibers, and optionally applying an aftertreatment agent to the keratinic fibers.

Abstract: A malodour-counteracting composition comprising (i) a salt of general formula (I) R1R2R3R4N+X???(I) wherein R1 ,R2 , R3 , R4 are independently selected from C1-4 alkyl, or R1, R2, R3, R4 may together constitute a nitrogen-containing cyclic system in which the nitrogen is part of a pyridinium or an imidazolinium ring; and X? is a counterion characterised by its protonated form having an acidity constant (pKa) lying between 1 and 6; and (ii) an alpha, beta-unsaturated carbonyl compound of the general formula R5R6C?CR7C(?O)YR8 ??(II) wherein R5, R6, R7 and R8 are independently selected from hydrogen and C1-10 hydrocarbyl residues which may be saturated, unsaturated, aromatic, cyclic, branched or unbranched, and are optionally substituted, or R5, R6, R7 and R8 may together constitute a cyclic system and Y is oxygen or a single covalent bond, with the proviso that Y is a covalent bond when R8 is hydrogen.

Abstract: The present invention aims to provide a multilamellar vesicle preparation which can be produced conveniently and is superior in stability. A multilamellar vesicle preparation containing component (A): a compound represented by the formula (1) wherein each symbol is as described in the SPECIFICATION, or a salt thereof, component (B): a physiologically active substance, and component (C): water.

Abstract: The present invention relates to a composition comprising: (a) at least one liquid oil at 25° C., (b) at least one wax, (c) at least one oil gelling agent derived from glutamic acid, and (d) at least one nonionic surfactant. The composition according to the present invention provides high removability and good feeling after rinsing-off without requiring further cleansing. In addition, the composition according to the present invention can provide high stability and good spread ability.

Abstract: The present invention relates to a composition for dyeing keratin fibers, comprising (a) at least one direct dye; and (b) at least one sulfone compound represented by the following formula (I): wherein each of R1 and R2 independently denotes a monovalent C1-30 aliphatic group or a monovalent C6-30 aromatic group, which may optionally be substituted with at least one substituent; or R1 and R2, together with the sulfur atom which they are binding, form a 3-10 membered ring which may optionally be substituted with at least one substituent. The composition according to the present invention is a one-part composition and can prevent or reduce skin staining by the direct dye on the skin such as the scalp, while providing the keratin fibers with good cosmetic effects such as good coloring properties.

Abstract: The invention relates to the cosmetic use, as a deodorant active agent, of spiculisporic acid in free form, partially or fully neutralised by at least one mineral and/or organic base. The invention also relates to a cosmetic method for treating human body odours, in particular the armpits or feet, in which at least one spiculisporic acid as defined above or a composition containing same in a physiologically acceptable medium is applied to the human keratin material.

Abstract: The present invention relates to a composition containing a chemokine, particularly, an interferon-inducible T-cell alpha chemoattractant (ITACT) which can decrease the gene expression of a factor related to melanin pigment production in melanocytes, thereby exhibiting a skin whitening effect.

Abstract: This invention relates to a foamable concentrated hair care composition comprising an anionic surfactant, a co-surfactant, a viscosity reducing agent, and a cationic polymer. The hair care composition may further comprise a silicone, wherein the silicone particle size is less than about 10 microns. The hair care composition has a viscosity of from about 1 to about 3,000 cps.

Abstract: The invention relates to a cosmetic process for caring for the skin, more particularly facial skin, in particular wrinkled skin, comprising: (i) a step consisting in applying to the skin a composition, in particular a cosmetic composition, comprising, in a physiologically acceptable medium, a polysaccharide polymer grafted with (meth)acrylate groups and a photoactive compound, (ii) followed by a step consisting in exposing the skin to light radiation, preferably for at least 5 seconds. The invention also relates to a composition comprising, in a physiologically acceptable medium, a polysaccharide polymer grafted with (meth)acrylate groups and a photoactive compound.

Abstract: The present invention relates to an anhydrous composition comprising: 1) at least particles comprising a core containing at least one beneficial agent and an envelope surrounding the core; said envelope comprising at least one hydrophobically modified polysaccharide and at least one water-soluble carbohydrate and/or water-soluble polyol; said particles simultaneously having a poured powder density ranging from 300.0 g/l to 600.0 g/l and an absolute density of greater than 1.0; and 2) an oily phase. The invention additionally relates to a cosmetic process for caring for and/or for making up a keratin material, which consists in applying to the surface of said human keratin material a consumer product comprising a composition as defined previously.

Abstract: Provided is a method for making an herbal soap for alleviating atopic skin disease, the method comprising combining five main medicinal herbs consisting of Kalopanacis cortex, Amaranthus mangostanus, Gardenia jasminoides, Lonicerae flos and Rumex japonicus Houtt with four supplementary medicinal herbs consisting of Glycyrrhiza uralensis Fischer, Mori cortex, Phaseoli radiati semen and red ginseng, which serve to increase the efficacies of the five main medicinal herbs, and refined horse fat containing unsaturated fatty acids and vitamin E, according to an herb combination method that is used in Chinese medicine. According to the method, active ingredients effective for atopic dermatitis patients can be extracted from the medicinal herbs. The herbal extract obtained according to the method exhibits excellent effects on the fundamental treatment of diseases having a high correlation with atopic dermatitis patients and on the alleviation of atopic dermatitis.

Abstract: The present invention is directed to a personal care composition comprising: a hair restorative blend comprising a chalconoid, an Epilobium extract, and cosmetically acceptable carrier.

Abstract: The present invention is directed to a method for treating the appearance of thinning hair of a human comprising the steps of; cleaning the hair with a shampoo composition; rinsing said shampoo from said hair; and applying a hair restorative blend to the scalp of said human, said hair restorative blend comprising; a chalconoid, an Epilobium extract, and a cosmetically acceptable carrier.

Abstract: A cosmetic composition for skin whitening, wrinkle improvement or skin regeneration includes, as an active ingredient, exosomes derived from stem cells comprising proliferating stem cells.

Abstract: Formulations for oral transmucosal compositions that include aromatase inhibitors (AIs) in combination with transmucosal absorption enhancers are disclosed. Disclosed oral transmucosal compositions may be for immediate release or slow release, and may be administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency. Disclosed oral transmucosal compositions may include liquid dosage forms, solid dosage forms, and chewing gums. Further dosage forms may include mucoadhesive thin strips, thin films, tablets, patches, and tapes, among others. Other dosage forms may be: mucoadhesive liquids such as gel-forming liquid; gel-forming; semisolids; and gel-forming powders, among other dosage forms that exhibit mucoadhesive properties, and provide oral transmucosal delivery of AIs. Disclosed oral transmucosal compositions may allow the delivery of AIs directly into the patient's bloodstream, thus providing high bioavailability of AIs; therefore, required dose may be lower.

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

Abstract: Compositions and methods for inducing pterygium regression from visual axis/central cornea, stabilizing pterygium, treating hyperemia and symptoms in pterygium patients, and treating pterygium recurrence following pterygiectomy are disclosed. The methods include administration of a multikinase inhibitor, an antimetabolite or a combination thereof to patients in need thereof.

Abstract: The invention provides a semi-solid chewable dosage form that contains one or more active pharmaceutical ingredients that are generally available as over-the-counter medications including, for example, chlorpheniramine maleate, phenylephrine hydrochloride, guaifenesin, dextromethorphan hydrobromide, loratadine, or a combination thereof. The invention further provides a semi-solid chewable dosage form that contains chlorpheniramine maleate, phenylephrine hydrochloride or a combination thereof, a gelling agent, gelatin, sugar, a polyol, and a pH adjusting agent. The invention further provides a semi-solid chewable dosage form that contains the active pharmaceutical ingredient chlorpheniramine maleate, phenylephrine hydrochloride or a combination thereof, a gelling agent, gelatin, sugar, corn syrup, and a pH adjusting agent. The semi-solid chewable dosage form is useful for administration to individuals to treat symptoms from allergies, colds, congestion, and the like.

Abstract: The invention provides a semi-solid chewable dosage form for use as an over-the-counter medication that contains an active pharmaceutical ingredient to treat symptoms associated with allergies, colds, coughs, fever, pain, gastrointestinal disorders, sleep, and other common conditions. The invention further provides a semi-solid chewable dosage form that contains an active pharmaceutical ingredient, a gelling agent, gelatin, sugar, a polyol, and a pH adjusting agent. The invention also provides a semi-solid chewable dosage form that contains a gelling agent, sugar, a polyol, glycerin, and a pH adjusting agent.

Abstract: Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.

Abstract: The present invention discloses a method for producing amorphous solid dispersions in a nanoparticulate form, through solvent controlled co-precipitation, using microfluidization/microreaction technology to promote high energy mixing/interaction at a micro and/or molecular level between the streams involved in the process. Feed streams, solvent and anti-solvent, are fed to an intensifier pump at individually controlled rates and forced to interact to micro- and/or nano-scale within a microreactor. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.

Abstract: The present invention relates to a drug delivery system (DDS) for crossing the blood-brain barrier (BBB) formed by self-assembly of an amphiphilic block copolymer, comprising a self-assembled structure having an average diameter of 5 nm to 20 nm of a core-shell structure comprising a hydrophobic core and a hydrophilic shell; and a hydrophobic drug supported in the hydrophobic core of the self-assembled structure, a pharmaceutical composition for preventing or treating cerebral diseases comprising the drug delivery system as an active ingredient, and a preparation method of the drug delivery system.

Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.

Abstract: Disclosed are compositions including nanoparticles comprising a poorly aqueous soluble polymer, an ionizable active agent, and a counterion having an opposite charge as the ionizable active agent, as well as methods of making and using the compositions.

Abstract: Antiviral compositions comprising a modified nuclease, or a plurality of such modified nucleases having at least one non-natural amino acid residue substituted for a naturally occurring amino acid in a parent nuclease are provided, as are methods of use and kits providing unit dosages of such compositions.

Abstract: Provided herein is a polyvinyl alcohol fine particle suitable for a pharmaceutical binder for obtaining a pharmaceutical tablet of properties including good sustained release, high hardness, and excellent friability. The polyvinyl alcohol tine particle of the present invention contains 25 mol % or more of a gauche structure in polyvinyl alcohol molecules within a 0.8-nm region inside the particle from the particle surface.

Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.

Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.