Patents Issued in July 27, 2017
  • CATALYST COMPOSITION AND PROCESS FOR PREPARING LINEAR ALPH OLEFINS
    Publication number: 20170210680
    Abstract: The present disclosure relates to a catalyst composition for the oligomerization of ethylene comprising a zirconium-containing catalyst and an organoaluminum-containing co-catalyst. The disclosure also relates to a process for oligomerization of ethylene in the presence of the catalyst composition according to the disclosure. The disclosed process results in C4-C2o linear alpha olefins having improved linearity.
    Type: Application
    Filed: July 14, 2015
    Publication date: July 27, 2017
    Inventors: Shahid Azam, Bander Bawareth, Mohammed H. Al-Hazmi, Dafer M. Alshahrani
  • PROCESS FOR THE PRODUCTION OF BIARYL COMPOUNDS
    Publication number: 20170210681
    Abstract: Process for producing biaryl compounds by aerobic cross dehydrogenative coupling (CDC) of two arene groups comprising at least one aryl carbon-hydrogen bond, in the presence of a catalyst system comprising a palladium salt comprising at least one non-cyclopalladatable carboxylate anion and one or more non-beta-eliminatable, non-cyclopalladatable ligands comprising at least one N-donor atom, the one or more ligands having a 0.5/1-1.5/1 molar ratio of N-donor atoms relative to the Pd atoms.
    Type: Application
    Filed: July 15, 2015
    Publication date: July 27, 2017
    Applicant: DSM IP Assets B.V.
    Inventor: Paulus Lambertus ALSTERS
  • PROCESS FOR THE PRODUCTION OF HIGH-PURITY PARAXYLENE FROM A XYLENES CUT, USING TWO SIMULATED MOVING BED SEPARATION UNITS OPERATING IN SERIES AND TWO ISOMERIZATION UNITS.
    Publication number: 20170210682
    Abstract: The present invention describes a process for the production of high-purity paraxylene from a xylenes cut capable of containing ethylbenzene and C9 compounds, said process using two simulated moving bed separation units operating in series and two isomerization units.
    Type: Application
    Filed: June 10, 2015
    Publication date: July 27, 2017
    Applicant: IFP Energies nouvelles
    Inventors: Heloise DREUX, Philibert LEFLAIVE, Damien LEINEKUGEL LE COCQ
  • METHOD FOR THE PRODUCTION OF PARAXYLENE, COMPRISING TWO SIMULATED MOVING BED SEPARATION AND TWO ISOMERIZATION UNITS, ONE BEING IN THE GAS PHASE
    Publication number: 20170210683
    Abstract: The present invention describes a process for the production of high-purity paraxylene from a xylenes cut containing xylenes and ethylbenzene, a process using two simulated moving bed separation units and two isomerization units.
    Type: Application
    Filed: June 10, 2015
    Publication date: July 27, 2017
    Applicant: IFP Energies nouvelles
    Inventors: Heloise DREUX, Philibert LEFLAIVE, Damien LEINEKUGEL LE COCQ
  • ZEOLITES FOR HYDROCARBON CONVERSION
    Publication number: 20170210684
    Abstract: A process is provided for the conversion of a hydrocarbon feedstock using catalyst system comprising one or more zeolites. The zeolites have been identified to be capable of selectively catalyzing the hydroisomerization reactions of linear or slightly branched long-chain hydrocarbons. Also provided is a method for the systematic discovery of zeolite framework types that are suitable for such conversion processes, according to a set of criteria: large affinity towards linear alkanes, high adsorption selectivity of linear over branched alkanes, and low adsorption selectivity of linear alkanes of different molecular weights.
    Type: Application
    Filed: July 22, 2015
    Publication date: July 27, 2017
    Inventors: Joern Ilja Siepmann, Peng Bai, Michael Tsapatsis, Michael W. Deem
  • HIGH CONVERSION AND SELECTIVITY ODH PROCESS
    Publication number: 20170210685
    Abstract: Ethane may be catalytically oxidatively dehydrogenated to ethylene at high conversions and high selectivity in a circulating fluidized bed (CFB) reactor in the presence of oxygen in the feed in an amount above the flammability limit. The reactor has an attached regeneration reactor to regenerate the catalyst and cycle back to the CFB.
    Type: Application
    Filed: October 8, 2015
    Publication date: July 27, 2017
    Applicant: NOVA Chemicals (International) S.A.
    Inventors: Vasily Simanzhenkov, Shahin Goodarznia, Xiaoliang Gao, Kamal Serhal, Leonid Kustov, Aleksey Kucherov, Elena Finashina
  • PROCESS FOR MANUFACTURING TETRAFLUOROPROPENE
    Publication number: 20170210686
    Abstract: A process for manufacturing tetrafluoropropene, including, alternately: at least one step of reacting a chlorinated compound with hydrofluoric acid in the gas phase, in the presence of a fluorination catalyst, the proportion of oxygen optionally present being less than 0.05 mol. % relative to the chlorinated compound; a step of regenerating the fluorination catalyst by bringing the fluorination catalyst into contact with a regeneration stream including an oxidizing agent. Also, equipment suitable for carrying out this process.
    Type: Application
    Filed: June 22, 2015
    Publication date: July 27, 2017
    Applicant: ARKEMA FRANCE
    Inventors: Anne PIGAMO, Laurent WENDLINGER, Dominique DEUR-BERT
  • Methods for Preparing Diol
    Publication number: 20170210687
    Abstract: Provided is a method for preparing a diol. In the method, a saccharide and hydrogen as raw materials are contacted with a catalyst in water to prepare the diol. The employed catalyst is a composite catalyst comprised of a main catalyst and a cocatalyst, wherein the main catalyst is a water-insoluble acid-resistant alloy; and the cocatalyst is a soluble tungstate and/or soluble tungsten compound. The method uses an acid-resistant, inexpensive and stable alloy needless of a support as a main catalyst, and can guarantee a high yield of the diol in the case where the production cost is relatively low.
    Type: Application
    Filed: September 23, 2015
    Publication date: July 27, 2017
    Inventors: Jing Liu, Hongbin Qi, Haiyu Ren, Indra Prakash, Yu Shi
  • PRODUCTION OF 1,5-PENTANEDIOL VIA UPGRADING OF TETRAHYDROFUFURYL ALCOHOL
    Publication number: 20170210688
    Abstract: A method of making 1,5-pentanediol from tetrahydrofurfural alcohol. The method includes the steps of dehydrating tetrahydrofurfural alcohol (THFA) to dihydropyran (DHP); hydrating at least a portion of the DHP to 2-hydroxy-tetrahydropyran (2-HY-THP) in the absence of homogeneous acid; and hydrogenating at least a portion of the 2-HY-THP to 1,5-pentanediol. The method can be conducted entirely in the absence of noble metal catalysts.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 27, 2017
    Inventors: George Willis Huber, James A. Dumesic, Kevin J. Barnett, Zach J. Brentzel
  • BISPHENOL ALTERNATIVE DERIVED FROM RENEWABLE SUBSTITUTED PHENOLICS AND THEIR INDUSTRIAL APPLICATION
    Publication number: 20170210689
    Abstract: A compound is provided according to structure 4, (4) wherein n has a value from 0 to 48 and Z is hydroxyl or a benzene ring bearing substituents R11-R15, wherein R1-R15 are each individually selected from the group consisting of H, allyl, alkyl, alkoxy, phenyl, phenoxy, halide, hydroxyl, glycidyl, (meth)acryloyl, 3-(meth)acryloyl-2-hydroxy-1-propoxy, 2,3-epoxypropyl, maleate, and structure (a) wherein at least one of R1-R5, at least one of R6-R10, and at least one of R11-R15 is hydroxyl or an ether or ester derived from it.
    Type: Application
    Filed: May 27, 2015
    Publication date: July 27, 2017
    Applicants: UNIVERSITY OF DELAWARE, DEPARTMENT OF THE ARMY, ROWAN UNIVERSITY
    Inventors: Deborah WOOL, Kaleigh Havery RENO, Joseph Francis STANZIONE, Joshua M. SADLER, John Joseph LASCALA, Eric David HERNANDEZ
  • ACETIC ACID PROCESS
    Publication number: 20170210690
    Abstract: The present disclosure provides for a method for measuring the concentration of one or more components in a reactor or a separation unit of an acetic acid process by Raman spectroscopic analyses. In some embodiments, the conditions in the reactor or in any subsequent step of the acetic acid production process are adjusted in response to the measured concentration of one or more components.
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: LyondellBasell Acetyls, LLC
    Inventors: Noel C. Hallinan, David L. Ramage, David A. Heaps
  • COMPOSITIONS AND METHODS RELATED TO HALF SALTS OF HERBICIDAL CARBOXYLIC ACIDS
    Publication number: 20170210691
    Abstract: Half salts of certain synthetic auxin herbicides are provided. These half salts are useful for controlling unwanted plant growth. The half salts have low solubility in water, low volatility relative to commercial compositions of the corresponding synthetic auxin herbicides, and offer comparable herbicidal performance when compared to existing salts of the synthetic auxin herbicides.
    Type: Application
    Filed: March 9, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Lei Liu, Holger Tank, Melissa Gail Olds, Stephen L. Wilson
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20170210692
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: June 10, 2015
    Publication date: July 27, 2017
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • ADDITION-FRAGMENTATION AGENTS
    Publication number: 20170210693
    Abstract: Addition-fragmentation agents of the formula are disclosed: wherein R1, R2 and R3 are each independently Z-Q-, a (hetero)alkyl group or a (hetero)aryl group with the proviso that at least one of R1, R2 and R3 is Zm-Q-, Q is a linking group have a valence of m+1; Z is an ethylenically unsaturated polymerizable group, m is 1 to 6; each X1 is independently —O— or —NR4—, where R4 is H or C1-C4 alkyl, and n is 0 or 1.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Inventors: Guy D. Joly, Larry R. Krepski, Ann R. Fornof, Serkan Yurt, Babu N. Gaddam, Ahmed S. Abuelyaman
  • METHOD FOR SKIN-WHITENING USING COMPOSITION CONTAINING RESVERATRYL TRIGLYCOLATE
    Publication number: 20170210694
    Abstract: The present invention relates to a method for skin-whitening using a composition containing resveratryl triglycolate as an active ingredient, and more specifically, relates to a composition for skin-whitening containing resveratryl triglycolate or a cosmetically or pharmaceutically acceptable salt thereof as an active ingredient, a method for skin-whitening including applying or administering a composition containing resveratryl triglycolate or an acceptable salt thereof as an active ingredient to a subject, and a resveratryl triglycolate compound which has a skin-whitening effect. Since resveratryl triglycolate of the present invention can inhibit melanin synthesis and brighten skin tone, it can be effectively used as a cosmetic composition and a pharmaceutical composition for skin-whitening.
    Type: Application
    Filed: November 9, 2016
    Publication date: July 27, 2017
    Inventors: Yong Chool BOO, Won Choul PARK
  • METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND
    Publication number: 20170210695
    Abstract: The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound to the second compound. The present disclosure further describes a one-pot method for coupling a first compound to a second compound.
    Type: Application
    Filed: October 8, 2015
    Publication date: July 27, 2017
    Inventors: Patrick S. Hanley, Thomas P. Clark, Matthias S. Ober, William J. Kruper, JR.
  • Process for the Preparation of Metaraminol
    Publication number: 20170210696
    Abstract: Object of the invention is a process for the preparation of Metaraminol and the salts thereof, in particular its pharmaceutically acceptable salts, especially Metaraminol bi-L-tartrate. Object of the invention is also the use of a novel catalyst and a novel ligand for the synthesis of Metaraminol and its salts.
    Type: Application
    Filed: January 25, 2017
    Publication date: July 27, 2017
    Inventors: Davide BRENNA, Andrea MARCHESI, Voichita MIHALI
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170210697
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 27, 2017
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170210698
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 27, 2017
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • PREPARATION AND BIOLOGICAL EVALUATION OF VIRIDICATUMTOXIN ANALOGS
    Publication number: 20170210699
    Abstract: In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.
    Type: Application
    Filed: July 22, 2015
    Publication date: July 27, 2017
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Kyriacos C NICOLAOU, Christopher R.H. HALE, Christian NILEWSKI, Heraklidia IOANNIDOU, Abdellatif EL MARROUNI
  • 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING
    Publication number: 20170210700
    Abstract: The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Inventors: ALAIN WAGNER, OLEKSANDR KONIEV
  • SUBSTITUTED CYANO CYCLOALKYL PENTA-2,4-DIENES, CYANO CYCLOALKYL PENT-2-EN-4-YNES, CYANO HETEROCYCLYL PENTA-2,4-DIENES AND CYANO HETEROCYCLYL PENT-2-EN-4-YNES AS ACTIVE SUBSTANCES
    Publication number: 20170210701
    Abstract: The invention relates to cyano cycloalkyl penta-2,4-dienes, cyano cycloalkyl pent-2-en-4-ynes, cyano heterocyclyl penta-2,4-dienes and cyano heterocyclyl pent-2-en-4-ynes of general formula (I), or the salts thereof, where [X-Y], Q, R1, R2, A1, A2, V, W, m and n have the definitions specified in the description. The invention also relates to a production method for same and to the use of same for increasing stress tolerance in plants against abiotic stress, and/or for increasing the plant yield.
    Type: Application
    Filed: July 17, 2015
    Publication date: July 27, 2017
    Inventors: Jens FRACKENPOHL, Lothar WILLMS, Jan DITTGEN, Dirk SCHMUTZLER, Jeffrey Martin HILLS, Juan Pedro RUIZ-SANTAELLA MORENO
  • METHOD FOR PRODUCING XYLYLENE DIISOCYANATES IN THE GASEOUS PHASE
    Publication number: 20170210702
    Abstract: The invention relates to a method for producing the isomers 1,3- and/or 1,4-xylylene diisocyanates by reacting the corresponding 1,3- and/or 1,4-xylylene diamines with phosgene in the gaseous phase.
    Type: Application
    Filed: April 13, 2015
    Publication date: July 27, 2017
    Inventors: Reinhard Halpaap, Ralph Weber, Josef Sanders, Frank Richter, Elsa Karoline Schadlich, Armin Schymura, Martin Ehrig, Sebastian Hoch, Robert Maleika
  • METHOD FOR PREPARATION OF AMMONIA GAS AND CO2 FOR A UREA SYNTHESIS PROCESS
    Publication number: 20170210703
    Abstract: The invention relates to a process for preparing ammonia gas and CO2 for urea synthesis. In the process of the invention, a process gas containing nitrogen, hydrogen and carbon dioxide as main components is produced from a metallurgical gas. The metallurgical gas consists of blast furnace gas, or contains blast furnace gas at least as a mixing component. The process gas is fractionated to give a gas stream containing the CO2 component and a gas mixture consisting primarily of N2 and H2. An ammonia gas suitable for the urea synthesis is produced from the gas mixture by means of ammonia synthesis. CO2 is branched off from the CO2-containing gas stream in a purity and amount suitable for the urea synthesis.
    Type: Application
    Filed: March 29, 2017
    Publication date: July 27, 2017
    Inventors: Christoph Meißner, Denis Krotov, Olaf von Morstein, Matthias Patrick Krüger
  • DEUTERO-PHENFORMIN DERIVATIVES
    Publication number: 20170210704
    Abstract: The present disclosure is directed to novel phenformin derivatives, and their pharmaceutically acceptable salts, solvates, or stereoisomers thereof. This disclosure also provides compositions and the use of such compositions in method of treating cancer, diabetes, or polycystic ovarian syndrome.
    Type: Application
    Filed: January 23, 2017
    Publication date: July 27, 2017
    Inventor: David CAMPBELL
  • PROCESS FOR THE PREPARATION OF DIBENZENESULFONIMIDE
    Publication number: 20170210705
    Abstract: The present invention provides a process for the preparation of dibenzenesulfonimide.
    Type: Application
    Filed: July 15, 2015
    Publication date: July 27, 2017
    Inventors: Thirupathi ARUMUGAM, Mariano Patrick PHILIPS, Dilli BABU, Maheshwaran CHELLAIAH, Sarathy IYENGAR, Rajdeep ANAND
  • SYNTHESIS OF 2,2,2-TRIFLUOROETHANETHIOL
    Publication number: 20170210706
    Abstract: A method of making CF3CH2SH, comprising a step of reacting CF3CH2X, wherein X is halide or tosylate, with MSH, where M is an alkali metal such as Na or K, to yield CF3CH2SH. More specifically, a method of making CF3CH2SH, a step of reacting CF3CH2CI with a molar excess of NaSH in a reaction medium of one or more polar organic solvents at a temperature of from about 70 C to about 110 C for a time of from about 1 to about 5 hours.
    Type: Application
    Filed: July 31, 2015
    Publication date: July 27, 2017
    Inventors: Robert George Syvret, Craig Alan Polsz, Dana Lee Swan, Vijay R. Srinivas
  • SULFONATE-BASED COMPOUND AND METHOD FOR PREPARING SAME
    Publication number: 20170210707
    Abstract: The present application relates to a sulfonate-based compound and a method for preparing the same.
    Type: Application
    Filed: June 18, 2015
    Publication date: July 27, 2017
    Applicant: LG CHEM, LTD.
    Inventors: Hyungsam CHOI, Joong Jin HAN, Chong Kyu SHIN, Youngjea KIM, Esder KANG
  • ALKYLBENZENE HYDROPEROXIDE PRODUCTION USING DISPERSED BUBBLES OF OXYGEN CONTAINING GAS
    Publication number: 20170210708
    Abstract: An apparatus for oxidation of a C8-C12 alkylbenzene reactant to a C8-C12 alkylbenzene hydroperoxide product, the re-actor can comprise: a flow reactor comprising a reactant inlet, an oxidate product outlet, wherein the reactor is configured to provide a liquid flow from the reactant inlet to the product outlet, a gas inlet configured to introduce an oxygen-containing gas into the reactor and an inlet sparger configured to flow gas bubbles comprising the oxygen-containing gas within the liquid flow, and wherein: the inlet sparger is configured to flow the gas bubbles having a diameter of 1.0 mm to 5.0 mm over a gas bubble residence time from 1 to 200 seconds, and/or the inlet sparger configured to flow the gas bubbles such that greater than or equal to 80% of the gas bubbles do not coalesce into larger bubbles over a gas bubble residence time of 1 to 200 seconds.
    Type: Application
    Filed: August 7, 2015
    Publication date: July 27, 2017
    Inventors: Mark Erik Nelson, Andrey Vladimirovich Zinenkov, Arkady Samuilovich Dykman
  • MONOMER AND POLYMER AND COMPENSATION FILM AND OPTICAL FILM AND DISPLAY DEVICE
    Publication number: 20170210709
    Abstract: A monomer represented by Chemical Formula 1: wherein in Chemical Formula 1, X1, X2, L1, Y1, Y2, R1 to R9, n1, and n2 are the same as described in the detailed description.
    Type: Application
    Filed: June 23, 2016
    Publication date: July 27, 2017
    Inventors: Dmitry ANDROSOV, Changki KIM, Masashi TSUJI, Hyunseok CHOI
  • 2-OXO-3,4-DIHYDROPYRIDINE-5-CARBOXYLATES AND THEIR USE
    Publication number: 20170210710
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Sylvain Picon, Karen Aknin, Rajaa Boulahjar, Barbara Dubanchet
  • COMPETITIVE PPAR-GAMMA ANTAGONISTS
    Publication number: 20170210711
    Abstract: The present invention pertains to a new compound E)-2-(5-((4-methoxy-2-(trifluoromethyl)quinolin-6-yl)methoxy)-2-((4-(trifluoromethyl) benzyl)oxy)-benzylidene) hexanoic acid (MTTB), and its derivatives. The compounds of the invention are useful as selective peroxisome proliferator-activated receptor gamma (PPAR?) antagonists and are indicated for the use in the treatment of immune related diseases such as systemic inflammation, sepsis and septic shock.
    Type: Application
    Filed: July 14, 2015
    Publication date: July 27, 2017
    Inventors: Tilo KNAPE, Andreas VON KNETHEN, Michael John PARNHAM, Manfred SCHUBERT-ZSILAVECZ, Mario WURGLICS, Daniel FLESCH
  • PROCESS FOR PREPARING PYRAZOLES
    Publication number: 20170210712
    Abstract: The present invention relates to a process for preparing a pyrazole compound of formula V, the process including cyclizing a hydrazone substituted ?,?-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.
    Type: Application
    Filed: July 30, 2015
    Publication date: July 27, 2017
    Inventors: Birgit Gockel, Daniel Saelinger, Sebastian Soergel, Michael Rack
  • PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS
    Publication number: 20170210713
    Abstract: The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Inventors: Jeffrey Lockman, Chiyou Ni, Jae Hyun Park, Minnie Park, Bin Shao, Laykea Tafesse, Jiangchao Yao, Mark A. Youngman
  • MACROCYCLIC COMPLEXES, THEIR PROCESS OF PREPARATION AND USE AS PET IMAGING AGENTS
    Publication number: 20170210714
    Abstract: The present invention concerns compounds of formula (I): their process of preparation and compositions thereof. The present invention also concerns their use as diagnostic agent in PET imaging.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Inventors: Claire DENIS, Vincent GAUMET, Aurélien VIDAL, Philippe AUZELOUX, Jean-Claude MADELMONT, Elisabeth MIOT-NOIRAULT, Jean-Michel CHEZAL
  • MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
    Publication number: 20170210715
    Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D1, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Pengcheng Patrick Shao, Feng Ye, Petr Vachal, Jayanth Thiruveliore Thatal
  • SUBSTITUTED N-ACETYL-L-CYSTEINE DERIVATIVES AND RELATED COMPOUNDS
    Publication number: 20170210716
    Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers? disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.
    Type: Application
    Filed: April 7, 2017
    Publication date: July 27, 2017
    Applicant: Promentis Pharmaceuticals, Inc.
    Inventors: Michael Neary, James Nieman, Steven Tanis, Daniel Lawton, Garry Smith
  • SYNTHESIS OF BENZOTHIAZEPINES
    Publication number: 20170210717
    Abstract: Methods for preparing the following compound are disclosed.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Applicant: GlaxSmithKline Intellectual Propety (No.2) Limited
    Inventors: Jiasheng GUO, Bing LIU, Mark B. MITCHELL, Michael T. MARTIN, Xiaoming ZHOU
  • PROCESS FOR THE EPOXIDATION OF AN OLEFIN
    Publication number: 20170210718
    Abstract: In a process for the epoxidation of an olefin, where a mixture comprising olefin, hydrogen peroxide, water and methanol with a weight ratio of water to methanol of less than 1 is passed through a catalyst fixed bed comprising a shaped titanium silicalite catalyst, catalyst breakage is reduced by conditioning the dry catalyst with at least one conditioning liquid comprising water and from 25 to 45% by weight methanol.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Guido Stochniol, Wolfgang WÖLL, Franz SCHMIDT
  • ELECTROCONDUCTIVE MEMBER FOR ELECTROPHOTOGRAPHY AND QUATERNARY AMMONIUM SALT
    Publication number: 20170210719
    Abstract: Provided is an electroconductive member for electrophotography in which movement of a quaternary ammonium salt toward the surface of a binder resin is suppressed and which exhibits a less reduction in electroconductivity through electrification. The electroconductive member for electrophotography comprises an electroconductive shaft core and a resin layer, and the resin layer comprises a binder resin and at least one selected from quaternary ammonium salts having structures represented by the formulae (1) to (8).
    Type: Application
    Filed: September 4, 2015
    Publication date: July 27, 2017
    Inventors: Satoru Nishioka, Satoru Yamada, Kazuhiro Yamauchi, Yuichi Kikuchi
  • ENANTIOSELECTIVE PROCESS FOR SYNTHESIS OF (+)- PETROMYROXOL AND ITS DIASTEREOMERS
    Publication number: 20170210720
    Abstract: An enantioselective process for the synthesis of (+)-petromyroxol and its Diastereomers from (3aR,5R,6aR)-2,2-dimethyl-5-((R)-oxiran-2-yl)tetrahydrofuro[2,3-d][1,3]dioxole.
    Type: Application
    Filed: March 17, 2016
    Publication date: July 27, 2017
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Chepuri Venkata Ramana, Venkannababu Mullapudi
  • METHODS FOR EXTRACTING AND CONVERTING HEMICELLULOSE SUGARS
    Publication number: 20170210721
    Abstract: The present disclosure relates to methods of producing hemicellulose and conversion products thereof from a biomass. Also provided are hemicellulose products and other conversion products thereof.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 27, 2017
    Inventors: Robert JANSEN, Noa LAPIDOT, Bassem HALLAC, James Alan LAWSON, Lee MADSEN, Brendon STOUT, Adam Tyler CARDEN, Michael A. FAISON, Philip TRAVISANO, Michael ZVIELY
  • NOVEL ANTIBIOTIC
    Publication number: 20170210722
    Abstract: The present invention relates to novel compounds, comprising an 8-or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria. The invention further relates to fermentation processes wherein fungi of the genus Ulocladium are used for producing the novel compounds.
    Type: Application
    Filed: July 30, 2015
    Publication date: July 27, 2017
    Applicant: Koninklijke Nederlandse Akademie Van Wetenschappen
    Inventors: Jeroen DEN HERTOG, Gisela Johanna VAN DER VELDEN, Jelmer HOEKSMA
  • MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
    Publication number: 20170210723
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: January 18, 2017
    Publication date: July 27, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Paul R. LePlae, JR., Thomas Barton, Xin Gao, Jim Hunter, William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • ALKYNYL ALCOHOLS AND METHODS OF USE
    Publication number: 20170210724
    Abstract: The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: April 7, 2017
    Publication date: July 27, 2017
    Applicant: Genentech, Inc.
    Inventors: Nicole Blaquiere, Georgette Castanedo, Jianwen A. Feng, Baihua Hu, Steven Staben, Po-wai Yuen, Guosheng Wu, Xingyu Lin, Jason Burch
  • 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME
    Publication number: 20170210725
    Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
    Type: Application
    Filed: August 30, 2016
    Publication date: July 27, 2017
    Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C.K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero, Gregory J. Pacofsky
  • 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS AND THERAPEUTIC USES THEREOF
    Publication number: 20170210726
    Abstract: Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cellproliferation inhibitors, and therapeutic uses and methods of preparation thereof, are disclosed.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Applicant: Beta Pharma, Inc.
    Inventors: Michael Nicholas Greco, Michael John Costanzo, Jirong Peng, Victoria Lynn Wilde, Don Zhang
  • [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS
    Publication number: 20170210727
    Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
    Type: Application
    Filed: August 3, 2015
    Publication date: July 27, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Helen Chen, Duane DeMong, Paul E. Finke, Christopher W. Plummer
  • Cannabinergic Nitrate Esters And Related Analogs
    Publication number: 20170210728
    Abstract: The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools and/or biomarkers. The novel cannabinergic nitrate ester compounds provide medicaments useful in treating a variety of diseases and medical disorders.
    Type: Application
    Filed: January 9, 2017
    Publication date: July 27, 2017
    Inventors: Alexandros Makriyannis, Venkata Kiran Vemuri
  • ERK INHIBITORS AND USES THEREOF
    Publication number: 20170210729
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 2, 2017
    Publication date: July 27, 2017
    Inventors: Nadia Haq, Deqiang Niu, Russell C. Petter, Lixin Qiao, Juswinder Singh, Zhendong Zhu