Abstract: The present disclosure is directed to an integrated electrostatic sensor for an engine. The sensor includes an outer housing having a body with a first end and a second end. The first end is configured for securing the sensor to the engine and includes a sensing face. The sensor also includes an electrode configured within the housing adjacent to the sensing face and an amplifier configured with the electrode. The electrode contains a plurality of electrons configured to move as charged particles flow past the sensing face. Thus, the amplifier is configured to detect a particulate level as a function of the electron movement. The electrostatic sensor also includes a circuit board configured within the housing and electrically coupled to the amplifier. As such, the circuit board is configured to send one or more signals to a controller of the engine indicative of the particulate level.

Abstract: A method of mass spectrometry is disclosed comprising separating a first population of ions according to their ion mobility and selectively attenuating ions in the first population of ions in one or more ion mobility and/or drift time ranges so as to form a second population of ions. The step of selectively attenuating ions comprises applying a varying, increasing or decreasing attenuation factor to ions in different ion mobility and/or drift time ranges. The method further comprises separating the second population of ions according to their ion mobility.

Abstract: The present technology is directed to the integration of a fixed ultrasonic device into a connector fitting adapted to connect fluid conduits, as well as methods of detecting the presence or absence of media passing through a fitting.

Abstract: Systems and methods for multi-layer ultrasonic imaging are provided. One embodiment is an apparatus that includes linear ultrasonic transducers that are each configured to conduct electricity across their length. The apparatus includes a first planar layer that comprises a first set of the transducers arranged in parallel. The apparatus also includes a second planar layer that comprises a second set of the transducers arranged in parallel, and that is oriented such that each transducer of the second set overlaps at least two transducers of the first set. Furthermore, the apparatus includes a third planar layer that comprises a third set of the transducers arranged in parallel, and that is oriented such that each transducer of the third set overlaps at least two transducers of the first set and at least two transducers of the second set.

Abstract: A deformation detecting device comprises a vibration module configured to vibrate a first point of a measuring plane of a measured object in a non-contact manner; a transmission time measurement module configured to measure transmission time of vibration from the first point to a second point of the measuring plane in a non-contact manner; an inclination measurement module configured to measure an inclination of the measuring plane to a reference surface in a non-contact manner; and a determination module configured to determine presence/absence of deformation in the measured object by comparing the transmission time with reference transmission time serving as transmission time of vibration from the first point to the second point in a case in which there is no inclination of the measuring plane and corrects the reference transmission time in response to the inclination of the measuring plane.

Abstract: An abnormality detection device, an abnormality detection method and an abnormality detection system for a rotating machine according to the present invention sample a vibration of a rotating machine at a predetermined sampling frequency, output for each predetermined period of time a set of a plurality of samples detected within the predetermined period of time, store the set of samples in a storage section, perform frequency analysis on the set of samples, and display in real time frequency analysis results in chronological order. A rotating machine according to the present invention includes the abnormality detection device.

Abstract: In one aspect, disclosed herein is a method for determining sulfate concentration in a sample, comprising: a) providing a liquid sample comprising urea and at least one impurity; b) concentrating the liquid sample under conditions effective to reduce the liquid volume; c) forming a dilute sample solution by diluting the concentrated liquid sample of step b) in water; and d) analyzing the dilute sample solution of step c) with ion chromatography to determine if a concentration of sulfate is present in the provided liquid sample of step a); wherein the analyzing of step d) is capable of determining the presence of a sulfate concentration present in an amount less than about 1 ppm.

Abstract: A chambered ion reflux device for ion chromatography which electrolytically produces an eluent from a water pumped phase, suppresses the eluent and recovers (refluxes) the eluent ions for reuse. In the chambered ion reflux device, the eluent never passes through the electrode chambers. Since the eluent ions are refluxed and the eluent is produced electrolytically, the chambered ion reflux device can be used for isocratic or gradient ion chromatography. A chambered ion reflux device which integrates an electrolytic ion removal chamber is also disclosed.

Abstract: Provided herein is technology relating to detecting gaseous analytes and particularly, but not exclusively, to devices and methods related to detecting gaseous analytes by monitoring changes in liquid crystals upon exposure to the gaseous analytes.

Abstract: An object is enclosed but moveable within a container. An interior surface of the container includes two or more distinct areal segments exhibiting corresponding surface characteristics. Movement of the object while in contact with each areal segment results in a corresponding sensory input to a user moving the container. The corresponding surface characteristic of each areal segment differs from the corresponding surface characteristic of at least one other areal segment, so that the corresponding sensory inputs to the user resulting from movement of the object while in contact with those areal segments differ from one another. The corresponding sensory inputs can include auditory inputs, tactile inputs, visual inputs, olfactory inputs, or sensor readouts. The article can be employed in methods wherein a user identifies the object, or characterizes the object or areal segments, based on the sensory inputs.

Abstract: A gas sensor is provided with a metal shell protecting member formed of a material superior in heat resistance to a metal shell, whereby a high-temperature measurement target (exhaust gas) is prevented from being in direct contact with a region, of a protector internal region of the metal shell, on the front side relative to a protector opposing surface. That is, in the gas sensor, it is possible to suppress corrosion, due to high temperature, of a region, of the protector internal region of the metal shell, on the front side relative to the protector opposing surface (an inner surface and a front end surface of a protector fixing portion), while the metal shell is formed of a material (SUS430) that can be subjected to working (crimping or the like) accompanied with deformation. Therefore, heat resistance of the entire sensor can be improved.

Abstract: A calibration solution for a wet chemistry analyzer is provided. The solution comprises a calibration agent. The solution also comprises a cleaning agent. The cleaning agent is selected such that the wet chemistry analyzer is simultaneously cleaned and calibrated.

Abstract: The present invention provides a heavy metal detecting device and the fabricating method thereof. The heavy metal detecting device comprises a substrate and a nano-metal-particle array. The fabricating method of the heavy metal detecting device comprises following steps of: (S1) preparing a substrate, cleaning the substrate with a first liquid, and drying the substrate with a first gas; (S2) soaking the substrate in a first solution; (S3) after soaking the substrate for a first period of time, cleaning and drying the substrate with the first liquid and the first gas respectively; (S4) soaking the substrate in a pre-synthesized nano-metal-particle solution; and (S5) after soaking the substrate for a second period of time, cleaning and drying the substrate with a second liquid and the first gas respectively. Compared to the prior arts, the heavy metal detecting device of the present invention has the advantages of simplicity and rapidity.

Abstract: The present invention concerns a system (1) for extracting gas or gas mixtures from a liquid for performing dissolved gas or gas mixture analysis, the system (1) comprising a container (2) for storing a liquid and/or a gas or gas mixture, a liquid pump (3) which is connected to the container (2), a means for feeding the system (1) with a liquid and emptying the system (1) of the liquid, a gas analyzer which is connected to the container (2), and a piping (14) which is connected to the container (2), and wherein the piping (14), the liquid pump (3) and the container (2) are configured to circulate the liquid. The invention also concerns a method for extracting gas or gas mixtures from a liquid for performing dissolved gas or gas mixture analysis.

Abstract: A smart cap system includes a cap adapted to fit on a concrete test cylinder, the cap including one or more internal surfaces, and one or more sensors disposed in or on the one or more internal surfaces of the cap, the one or more sensors being adapted to obtain a measurement of a characteristic of a concrete mixture disposed in the test cylinder. The cap may be adapted to fit on one of a 4×8-inch cylinder and a 6×12-inch cylinder. The one or more sensors may include one of a temperature sensor, a humidity sensor, a chronometer, a heat flow sensor, a motion sensor, a pH sensor, a location detector, a GPS sensor, an accelerometer, a triangulation sensor, a thermoelectric heat flow sensor, a salinity sensor, a macro fiber composite (MFC) sensor, and a capillary sensor.

Abstract: The present invention relates to a wood test tool (1) for punching out and visually checking the core of a wood sample. The wood test tool (1) has a hollow cylindrical pin (11), comprising at one end an input opening (12) which corresponds to the inner diameter of the hollow cylinder, and at the other end a flattened head (13) as well as a viewing window (14), said viewing window extending over at least two thirds along the length of the hollow cylinder starting from the end of the hollow cylindrical pin (11) on the side of the input opening. Further disclosed is a method for checking the impregnation depth of an impregnated wood object (4).

Abstract: A system and method for testing and ejecting a test strip of a fluid testing medical device. The system includes parallel first and second guide rails defining a rail cavity between the guide rails. A sled includes a sled post and opposed first and second side leg sets each having at least one deflectable leg. Each of the deflectable legs is externally slidably engaged to one of the guide rails limiting the sled to only sliding motion in either a loading direction or an opposite ejection direction. An actuator arm is rotatably connected to a mechanism assembly. The sled post is received in an actuator arm slot. Actuator arm rotation in a loading rotational direction displaces the sled in the loading direction in a sliding motion. Subsequent opposite rotation of the actuator arm in an ejection rotational direction displaces the sled in the ejection direction and ejects the test strip.

Abstract: A contact structure body for use in a measuring device. The contact structure includes a separator that physically separates a sample holder from a measuring circuit, and a contact probe configured to electrically connect an electrode of the sample holder to the measuring circuit, the contact probe comprising. The contact structure body may be part of a system for determining a characteristic of a sample. The system includes a sample holder for holding sample. The sample holder includes an electrode. The system also includes a measuring circuit for measuring at least one property of the sample.

Abstract: A technique relates to stretching an extensible molecule. The molecule moves through an array of pillars in a flow direction, where the array has an interface connecting a first pillar region and a second pillar region. Stretching the molecule by traversing the molecule in the flow direction through the interface connecting the first pillar region to the second pillar region, such that a first end and a second end of the molecule straddle a straddle pillar, thereby causing the first end to extend along a first path in the second and the second end to extend along a second path. Traversing the molecule stretches the first end and the second end along two different paths. The molecule is further traversed through the array such that the second end follows the first end along the first path, where the stretching causes the molecule to be in an uncoiled state.

Abstract: A urine sample testing apparatus may include a urine qualitative measuring section configured to acquire a measurement result for each of a plurality of urine qualitative measurement items and a urine sediment measuring section configured to acquire a measurement result for each of a plurality of urine sediment measurement items. The apparatus may also include an operation part that can specify a combination of one of the plurality of urine qualitative measurement items and one of the plurality of urine sediment measurement items. An information processing unit may also be included.

Abstract: A portable device having an exhalation sensing function is provided. The portable device includes a gas detector that analyzes exhalation, and a device main body including a receiving portion in which the gas detector is received, the device main body having a call function, wherein, when a user makes a call using the device main body, the gas detector is automatically projected from the receiving portion of the device main body, and senses the user's exhalation.

Abstract: Proximity coupling and sequencing methods to screen, identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

Abstract: The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder.

Abstract: The present invention is directed to methods for identifying the presence of one or more target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction.

Abstract: A sensor material includes a plurality of conductive carbonaceous nanomaterial particles, a detector selected to selectively interact with an analyte of interest; and an ionic liquid wherein the plurality of conductive carbonaceous nanomaterial particles, the detector and the ionic liquid are combined to form a paste. Further, the analyte can diffuse into the paste to interact with the detector to change the conductivity of the paste. Device based on said sensor material and methods or using said devices are also described.

Abstract: An engineered particle for detecting analytes in an environment includes an electromagnetic receiver that is configured to preferentially receive electromagnetic radiation of a specified polarization relative to the orientation of the electromagnetic receiver. The engineered particle additionally includes an energy emitter coupled to the electromagnetic receiver such that a portion of electromagnetic energy received by the electromagnetic receiver is transferred to and emitted by the energy emitter. The engineered particles are functionalized to selectively interact with an analyte. The engineered particle can additionally be configured to align with a directed energy field in the environment. The selective reception of electromagnetic radiation of a specified polarization and/or alignment with a directed energy field can enable orientation tracking of individual engineered particles, imaging in high-noise environments, or other applications.

Abstract: A nanowire molecular sensor, and a molecular detection system, comprising a nanowire waveguide (30), a nanowire sidewall (51) functionalized in order to attach a molecule (54), and light emissive point sources (52), wherein the amount of light emitted at an end (53) of the waveguide is dependent of the amount of specific molecules attached to the sidewall of the nanowire. A method employing said sensor may be used for single cell detection and analysis.

Abstract: The current invention is directed to the velocity factor. Based on the velocity factor antibodies can be classified, i.e. antibodies can be characterized on their binding properties as e.g. entropic or enthalpic antigen binder. A velocity factor based classification does not require detailed thermodynamic determinations and/or calculations. The velocity factor is the ratio of the antigen-antibody complex association rate constants ka determined at 37° C. and 13° C. As only two experimental determinations are required to calculate the velocity factor this is a fast and high-throughput suited method.

Abstract: A rapid diagnostic testing device for testing of a biological sample is provided. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing. The channeled construct is configured to receive a biological sample to form at least partially purified biological sample. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the partially purified biological sample comprising at least one analyte. The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte.

Abstract: Embodiments disclosed herein are directed to flow assays including at least one electrically-actuated valve configured to control fluid flow. Methods of operating such flow assays are also disclosed.

Abstract: A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

Abstract: A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

Abstract: Provided herein are integrated devices that improve sensitivity of rapid diagnostic tests. The devices described herein integrate sample separation with rapid diagnostic tests and improve signal intensity of the rapid diagnostic tests.

Abstract: The present invention relates to the field of Clostridium difficile infections. Methods of diagnosing, treating and preventing Clostridium difficile-associated disease and recurrent CDAD are disclosed herein.

Abstract: Novel Borrelia burgdorferi recombinant proteins and methods of assessing a sample for the presence of antibodies to certain proteins of Borrelia burgdorferi, are described, as are methods of diagnosing Lyme disease. Microarrays of proteins of Borrelia burgdorferi are also described.

Abstract: An ELISPOT method of in vitro diagnosis of tuberculosis includes enriching or separating liquid blood fraction from its cellular components including visualizing immunocompetent cells by detecting different dyes and using at least two different filter sets, each including one narrowband excitation filter and one narrowband blocking filter, wherein the narrowband excitation filter is transmissive for light provided for luminescent excitation of a respective dye and the narrowband blocking filter is transmissive for light emitted by a respective dye and measuring the number of immunocompetent cells that secrete at least interferon-? and interleukin-2 as a reaction to an antigen by superimposing at least two two-dimensional images generated during visualization to avoid luminescence of different dyes interfering and strong luminescence being superimposed on weak luminescence.

Abstract: The present invention relates to a biosensor for the determination of an infection and possible neoplasias associated with it.

Abstract: The invention relates to a novel antibody which binds to C-SLPI selected from the group consisting of SEQ ID NOs: 3 and 4.

Abstract: Biosensor and method of using the biosensors for the detection of prostate cancer are provided. The biosensors include a dual ionophore ion selective electrode for detecting very low levels of prostate cancer antigens at early stages of prostate cancer development.

Abstract: The present invention relates to: a composition for diagnosing pancreatic cancer, containing a preparation for measuring the expression level of a protein or a gene thereof, and capable of being used for determining whether there is a risk of pancreatic cancer; a kit; and a method for diagnosing pancreatic cancer by using the same. The present invention can significantly predict or identify the risk of pancreatic cancer or a precancerous lesion of pancreatic cancer, the early diagnosis thereof and the extent of diseases thereof by providing a diagnostic marker of pancreatic cancer, and can be utilized in the research of pancreatic cancer oncogenesis. In addition, the diagnostic method of the present invention can provide simple and early diagnosis of pancreatic cancer from the blood and the like in a non-invasive manner.

Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.

Abstract: One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.

Abstract: Disclosed herein are multiplex methods for co-detecting a B cell marker, TP53 nucleic acid, and Chromosome 17 centromere DNA in a single sample. Samples stained for the B cell marker (e.g., CD79a protein), TP53 nucleic acid, and Chromosome 17 centromere DNA may allow for the identification of the subtype of chronic lymphocytic leukemia (CLL) with the 17p deletion. The methods feature staining the B cell marker (e.g., CD79a) a first distinct color, TP53 in a second distinct color, and chromosome 17 centromere DNA in a third distinct color. Further disclosed are nucleic acid probes specific for 19q12, INSR, ATM, DLEU2, TP53, and 13q12.

Abstract: Provided herein is a method of using transposition to improve methods of sequencing RNA molecules. Provided herein is a method of tagging nucleic acid duplexes, such as DNA:RNA duplexes or DNA:DNA duplexes. The method includes the steps of providing a transposase and a transposon composition, providing one or more nucleic acid duplexes immobilized on a support, and contacting the transposase and transposon composition with the one or more nucleic acid duplexes under conditions wherein the one or more nucleic acid duplexes and transposon composition undergo a transposition reaction to produce one or more tagged nucleic acid duplexes, wherein the transposon composition comprises a double stranded nucleic acid molecule comprising a transferred strand and a non-transferred strand.

Abstract: The present invention relates to a cluster for the detection of an analyte, said cluster comprising a plurality of visually detectable colored particles and a plurality of luminescent particles, wherein (i) the particles are bound to each other, and (ii) at least one binding partner of an analyte is bound to the colored particles and/or the luminescent particles.

Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.

Abstract: The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and contacting the polypeptide with a plurality of probes. Each probe selectively binds to an N-terminal amino acid or an N-terminal amino acid derivative. Probes bound to the polypeptide molecule are then identified before cleaving the N-terminal amino acid or N-terminal amino acid derivative of the polypeptide. Also provided are methods for the sequencing a plurality of polypeptide molecules in a sample and probes specific for N-terminal amino acids or N-terminal amino acid derivatives.

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Abstract: Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for electrospray ionization (ESI) mass spectrometry. The method uses charged affinity molecules that can bind with analyte either temporarily or permanently to improve the desorption and ionization of analyte. The charged affinity molecules can be positively charged or negatively charged.

Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.