Abstract: The invention provides anti-oncostatin M receptor-? (OSMR) antigen binding proteins, e.g., antibodies and functional fragments, derivatives, muteins, and variants thereof. OSMR antigen binding proteins interfere with binding of OSM and/or IL-31 to OSMR. In some embodiments, anti-OSMR antigen binding proteins are useful tools in studying diseases and disorders associated with OSMR and are particularly useful in methods of treating diseases and disorders associated with OSMR and binding of OSM and/or IL-31 to OSMR.

Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.

Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

Abstract: The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.

Abstract: This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

Abstract: The present invention relates to a method of localizing an intact immunoglobulin-format antibody in cytosol by permeating membrane of cells. The present invention also relates to a light-chain variable region (VL) that induces an intact immunoglobulin-format antibody to penetrate the membrane of living cells and be localized in the cytosol, and to an antibody comprising the same. The present invention also relates to a biologically active molecule fused to the antibody and selected from the group consisting of peptides, proteins, small-molecule drugs, nanoparticles and liposomes. The present invention also relates to a composition for prevention, treatment or diagnosis of cancer, comprising: the antibody; or a biological active molecule fused to the antibody and selected from the group consisting of peptides, proteins, small-molecule drugs, nanoparticles and liposomes. The present invention also relates to a polynucleotide that encodes the light-chain variable region and the antibody.

Abstract: The present invention provides methods of site-specific labeling of antibodies, using proteins having 4?-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.

Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using particles (e.g., nanoparticles) containing (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell) and (b) one or more molecules having the ability to bind to an APC (e.g., a human macrophage) to treat cancer are provided.

Abstract: The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.

Abstract: The present invention provides methods for the diagnosis and/or treatment of chronic kidney disease, immune complex-mediated GN, rheumatoid arthritis, and pulmonary fibrosis, and methods for identifying compounds for such therapeutic use.

Abstract: Described herein are peptides from secretory phospholipase A2-IB and antibodies that can be used to reduce the contribution of the gastrointestinal tract to inflammatory processes including systemic inflammatory responses. Specifically, antibodies that bind specifically a peptide from secretory phospholipase A2-IB prevent death in a mouse model of LPS-induced endotoxemia. The antibodies described herein are particularly useful to treat systemic inflammatory response syndromes, including sepsis.

Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.

Abstract: Disclosed herein are engineered monovalent binding proteins that bind to one or more antigens, as well as methods of making and using the binding proteins in the prevention, diagnosis, and/or treatment of disease.

Abstract: The present invention relates to bispecific anti-TNF-?/IL-17A antibodies and anti-TNF-? antibodies, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.

Abstract: The present invention relates to an integrated process for processing and utilising every part of the guayule plant (Parthenium argentatum) which comprises the following steps in sequence: separating the stem and branches (3) from the leaves (2) of said plant with a mechanical treatment (1); treating the leaves (100) to produce waxes and essential oils (102), and a fraction (101) containing cellulose, hemicellulose (carbohydrates) and, to a minor extent, salts, organic compounds and lignin; extracting (200) from the stem and branches a liquid phase (4), so forming a first solid woody residue (5), indicated with bagasse in the present text; treating said first solid woody residue (5) to prepare sugars, resin, rubber and lignin.

Abstract: This invention relates to monodisperse cross-linked polymer particles, comprising particles with a substantially smooth outer surface and an average diameter of less than 1 ?m, wherein the particles are solid or porous, and wherein the coefficient of variation (CV) % of the particles, when measured by CPS disk centrifugation analysis, is less than 15%. These monodisperse cross-linked polymer particles may comprise magnetic material and are useful in various application. This invention also relates to monodisperse polymer particles for use as seed particles in the Ugelstad process.

Abstract: Provided are: a water-absorbent resin which, when used as an absorbent material, retains a high water-absorption performance, increases the diffusivity of a to-be-absorbed liquid and makes it possible to effectively decrease the amount of re-wet; and an absorbent article formed using an absorbent material including the water-absorbent resin. The water-absorbent resin according to the present invention is a water-absorbent resin obtained by polymerizing a water-soluble ethylenically monomer in the presence of an internal-crosslinking agent and thereafter post-crosslinking the polymer with a post-crosslinking agent, characterized in that when subjected to a liquid flow test, the water-absorbent resin has an effective absorbent material index (K) indicated by equation (I) of 250 or greater.

Abstract: The present invention is directed to partially fluorinated copolymers and the production thereof. More specifically, the copolymers, which are preferably produced by a solution polymerization process, preferably have at least three units, the first unit selected from 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene, the second unit having a polymerized monomer selected from the vinyl esters and vinyl ethers, and the third unit having a polymerized monomer derived from a hydroxyl group-containing vinyl ether. The resulting copolymer is environmentally friendly, has favorable molecular weight characteristics, and may be shipped economically in high concentration.

Abstract: Modified fluoropolymers, and methods for manufacturing modified fluoropolymers are provided. According to at least one embodiment, chemically modified fluoropolymers, via radical generation and subsequent reaction, produce fluoropolymers having fluorinated moieties and/or non-fluorinated moieties, disrupting highly coherent polar domains, wherein the non-fluorinated moieties include, for example, at least one of carbonyl, hydroxyl, alkoxy, alkyl, and/or aromatic chemical groups.

Abstract: The invention relates to a novel polyphosphorus-based chain-end thiol-functionalized polymer, the polymer chain of which comprises units bearing at least one pendant phosphonate function and/or at least one pendant phosphonic function along the chain. This novel polymer is quite particularly suited to participating in a thiol-ene coupling reaction, which affords the possibility of grafting the polyphosphorus-based polymers onto diene polymers, for example.

Abstract: The present disclosure provides a catalyst system made from or containing: (A) a solid catalyst component made from or containing (i) a titanium compound supported on a magnesium dichloride; (B) an aluminum alkyl compound; and (C) a halogenated organic ester of formula A-COOR, wherein R is a C1-C10 hydrocarbon group and A is a C1-C15 saturated or unsaturated hydrocarbon group in which at least one of the hydrogen atoms is replaced by a chlorine atom. The present disclosure also provides a process for preparing an olefinic polymer, including a polymerization step of polymerizing an olefin in the presence of the catalyst system. The present disclosure also provides an olefinic polymer made therefrom.

Abstract: The present invention relates to a thermoplastic block copolymer comprising at least one PA block and at least one PB block. The PA block represents a polymer block comprising one or more units of monomer A, and the PB block represents a polymer block comprising one or more units of monomer B. Monomer A is a vinyl, acrylic, diolefin, nitrile, dinitrile, acrylonitrile monomer, a monomer with reactive functionality, or a crosslinking monomer. Monomer B is a radically polymerizable triglyceride or mixtures thereof, typically in the form of a plant or animal oil. The present invention also relates to a method of preparing a thermoplastic block copolymer or novel thermoplastic statistical copolymers by polymerizing a radically polymerizable monomer with a radically polymerizable triglyceride or mixtures thereof via reversible addition-fragmentation chain-transfer polymerization (RAFT), in the presence of an free radical initiator and a chain transfer agent.

Abstract: This invention relates to methods to prepare and compositions pertaining to branched ethylene-propylene copolymers that include at least 50% ethylene content by weight as determined by FTIR; a g?vis of less than 0.95; a Mw of 125,000 to 300,000; a methylene sequence length of 6 or greater as determined by 13C NMR, wherein the percentage of sequences of the length of 6 or greater is more than 32%; and can have greater than 50% vinyl chain end functionality.

Abstract: The present disclosure provides a low density polyethylene (LDPE) having (A) a density from 0.910 to 0.924 g/cm3, determined according to ISO 1183 at 23° C.; (B) an elongational hardening of at least 4.2, at 150° C. at an elongational rate of 1 s?1; (C) a ratio Mw/Mn of at least 18, where (i) Mw is the weight average molar mass, measured by a MALLS detector coupled to a GPC, and (ii) Mn is the number average molar mass, measured by GPC (Gel Permeation Chromatography); and (D) a Mw of at least 230,000 g/mol. The present disclosure also provides an article of manufacture made from or containing (A) a substrate and (B) a coating layer made from or containing the disclosed LDPE. The present disclosure further provides a polymerization process occurring (A) in the presence of oxygen as the only radical initiating agent and (B) in the absence of solvents.

Abstract: Propylene random copolymers with low randomness and being free of from catalyst originating phthalates.

Abstract: The present invention relates to an olefin-based polymer exhibiting a single peak when analyzed by gel permeation chromatography (GPC), and having three elution temperatures Te1, Te2 and Te3 when measuring temperature rising elution fractionation (TREF) at a temperature ranging from ?20° C. to 120° C. Accordingly, the olefin-based polymer having excellent mechanical strength, and in particular, significantly improved impact strength is provided.

Abstract: A fluoroelastomer comprising a copolymer of fluoroolefin monomers selected from one or more of the group consisting of 2,3,3,3-tetrafluoropropene, 1,3,3,3-tetrafluoropropene and 1-chloro-3,3,3-trifluoropropene, and ethylenically unsaturated co-monomers; wherein the fluoroelastomer has a glass transition temperature (Tg) of from about ?60° C. to about 53° C. A process of making the fluoroelastomer.

Abstract: Alkoxylated fatty acids are disclosed herein, as well as methods of making and using such compounds. In some embodiments, the alkoxylated fatty acids are formed from monomers derived from natural oils. In some embodiments, the alkoxylated fatty acids are used as surfactants for making synthetic latex by emulsion polymerization. In some other embodiments, the alkoxylated fatty acids are used as surfactants for making synthetic rubber, such as styrene-butadiene rubber. In some other embodiments, the alkoxylated fatty acids are used as surfactants in a composition for treatment of gas or oil wells, for cleaning applications, for use in various laundry-related applications, for use in personal care compositions, or for use as solvents for coating applications, such as reactive and non-reactive waterborne coating applications.

Abstract: Provided is a method of producing a polycarboxylic acid-based polymer, the method including adding a monomer composition containing an unsaturated monocarboxylic acid-based monomer and/or an unsaturated dicarboxylic acid-based monomer to a reaction vessel to perform a polymerization reaction, which enables effective suppression of the foaming of a polymerization reaction liquid. The method of producing a polycarboxylic acid-based polymer of the present invention is a method of producing a polycarboxylic acid-based polymer, the method including adding a monomer composition containing an unsaturated monocarboxylic acid-based monomer and/or an unsaturated dicarboxylic acid-based monomer to a reaction vessel to perform a polymerization reaction, the method further including adding a defoaming agent by a time when 100 mass % of a total amount of the monomer composition is added.

Abstract: To obtain a modified polypropylene-based resin which shows specific viscoelasticity and from which an expanded sheet having a low open cell ratio can be obtained.

Abstract: The invention relates to aqueous polyurethane-vinyl polymer hybrid dispersions comprising, as building blocks, hydrophobically modified hydroxy-functional polyesters A, acids B that have further groups which react with isocyanates under formation of urethanes, ureas, or thiourethanes, compounds G having only one hydroxyl group, and one or more tertiary amino groups, olefinically unsaturated monomers H2 having a polymerisable ethylenic unsaturation and a further functional group which reacts with an isocyanate group under bond formation, olefinically unsaturated monomers H1 having at least one polymerisable ethylenic unsaturation and no further functional group which reacts with an isocyanate group, and multifunctional isocyanates I having at least two isocyanate groups per molecule, to a process of their preparation, and to a method of use thereof.

Abstract: A curable composition includes (A) a first component having from 5.0 wt % to 39.0 wt %, based on the total weight of the first component, of a toughening agent component including a Bisphenol F based epoxy resin and an urethane acrylate component, a hardener component having at least one amine based hardener and is present in a ratio of 0.8 to 1.2, based on a number of equivalents of amino hydrogen groups in the hardener component to a number of equivalents of reactive groups in the first component capable of forming a covalent link with the amine reactive groups in the hardener, and an epoxy base component that accounts for a remainder of the total weight of the first component and that has at least one epoxy resin separately provided from the Bisphenol F based epoxy resin. The Bisphenol F based epoxy resin is present in an amount from 2.5 wt % to 50.0 wt % and the urethane acrylate component is present in an amount from 50.0 wt % to 97.5 wt %, based on the total weight of the toughening agent component.

Abstract: A polymer complex is disclosed which is the reaction product of one or more polymers having a terminal or pendant hydroxyl group, or a terminal or pendent carboxyl group, or combinations thereof, with at least one metal complex and one alkyl phosphate. This polymer complex acts as an adhesion promotion agent as well as a viscosity stabilizer when formulated in a printing ink or coating.

Abstract: A thermoplastic epoxy matrix formulation, based on 100 parts by weight of the thermoplastic epoxy matrix formulation, includes 0.1 to 95 parts by weight of a difunctional epoxy resin and 0.1 to 80 parts by weight of a latent hardener, wherein the latent hardener is an amine compound containing two reactive hydrogens.

Abstract: An amine of the formula (I) for use as hardener for epoxy resins, hardeners for epoxy resins containing the amine of the formula (I) and resultant epoxy resin compositions which more particularly can be used as low-emission room-temperature-curing epoxy-resin coatings with high hardness and surface quality. The amine of the formula (I) has little odour and is a very successful diluent for epoxy resin compositions. It is more particularly obtained by reductive alkylation from 1,2-propylenediamine and an aldehyde or ketone.

Abstract: A composition including an amidoamine curing agent composition or a polyamide curing agent composition are disclosed. The composition includes the reaction products of (1) an amine component including at least one multifunctional amine of structure (I): wherein each R is independently H or CH2CH2CH2NH2; R1 is H, CH3CH2CH2N—, C1-C21 alkyl, or C1-C21 alkenyl; n is 2; and m is 1 or 2, with (2) a fatty acid or ester component selected from the group consisting of a dimer fatty acid or ester component, a monofunctional fatty acid or ester component, and combinations thereof. The amidoamine curing agent composition remains as liquid at ambient temperature.

Abstract: The present invention relates to the field of polymers used to form coatings at the surface of supports. More particularly, the invention relates to a polymer having adhesion properties, in particular with regard to an organic or inorganic support, characterized in that it comprises at least one and preferably several consecutive or non-consecutive structural units of formula (I): in which: B represents a carbonyl or —NR?— unit with R? representing a hydrogen atom, a C1 to C6 alkyl radical, or a C5 to C6 aryl, carbamate or acyl radical; and R represents: a hydrogen atom, a linear or branched, saturated or unsaturated C1 to C6 hydrocarbon-based radical which, where appropriate, is substituted with one or more halogen atoms, a C5 to C6 aryl radical, or an acyl, acyloxy, alkoxycarbonyl or cyano radical.

Abstract: Provided is a polymeric piezoelectric film containing an optically active helical chiral polymer (A) having a weight average molecular weight of from 50,000 to 1,000,000, in which a crystallinity obtained by a DSC method is from 20% to 80%, and the product of the crystallinity and a standardized molecular orientation MORc when a reference thickness measured by a microwave transmission-type molecular orientation meter is set to 50 ?m is from 25 to 700, and in which a surface roughness of at least one plane in terms of a non-contact three-dimensional surface roughness Sa measured by a confocal laser microscope is from 0.040 ?m to 0.105 ?m.

Abstract: A process for preparing a high molecular weight heteraromatic polyester or copolyester is disclosed. A process for preparing a high molecular weight heteroaromatic polyester or copolyester includes the steps of: (a) processing comonomers by mixing together to form a homogeneous solution (1) at least one heteroaromatic dicarboxylic acid having 2-12 carbon atoms or a diester or an acid anhydride derived therefrom, or a mixture thereof; (2) at least one alcohol having 2 to 12 carbon atoms and at least two hydroxyl functionalities; and (3) optionally aromatic or aliphatic dicarboxylic acids or diesters or acid anhydrides derived therefrom; (b) converting the paste/solution obtained in step a) into an esterification product containing at least one diester or at least one oligoester formed from the at least one heteroaromatic dicarboxylic acid and the at least one alcohol; and (c) polycondensing/copolycondensing the reaction product obtained from step b) under reduced pressure.

Abstract: The present invention relates to a process for continuous production of partly crystalline polycondensate pellet material, comprising the steps of forming a polycondensate melt into pellet material; separating the liquid cooling medium from the pellet material in a first treatment space, wherein the pellets after exit from the first treatment space exhibit a temperature TGR, and crystallizing the pellet material in a second treatment space, wherein in the second treatment space fluidized bed conditions exist, and in the second treatment space the pellets are heated by supply of energy from the exterior by means of a process gas.

Abstract: The invention provides polyglycerol alkoxylate esters and for the preparation and use thereof.

Abstract: The present invention relates to a rapid and innovative mechanism for initiating anionic ring-opening polymerization of laurolactam by means of latent initiators on the basis of thermally activatable N-heterocyclic carbene compounds, such as, more particularly, N-heterocyclic carbene-CO2 compounds and carbene-metal compounds (NHCs). With the new initiation mechanism it is possible accordingly to realize molecular weights (Mw) of from 2000 up to more than 30,000 g/mol, and narrow polydispersities. The polymerizations may be carried out both in bulk and in solution in a suitable solvent. Compounds of this type are thermally latent and on heating initiate a polymerization to polylaurolactam in high yields, up to a quantitative conversion, whereas at room temperature there is no reaction. Polydispersity and molecular weight of the polylaurolactam can be adjusted through the choice of the initiator and of the reaction conditions.

Abstract: The present invention relates to a process for preparing a granular nylon salt material, wherein an aqueous mixture, comprising at least 65 wt. % of salt components, and at most 35 wt. % of an aqueous medium, the weight percentages (wt. %) being relative to the total weight of the aqueous mixture, is flashed from a pressure vessel via a flash valve into a flash chamber, thereby evaporating the aqueous medium in an amount sufficient to result in a residual moisture content of at most 7.5 wt. %, and forming a granular nylon salt material. The invention also relates to a process for preparing a nylon polymer, comprising direct solid state polymerization of the granular salt material prepared by flash granulation.

Abstract: The present invention relates to amphiphilic block copolymers comprising reduction sensitive biodegradable polyesteramides. The present invention also relates to micelles comprising the amphiphilic block copolymers. The invention also relates to drug delivery systems comprising the micelles. The amphiphilic block copolymers comprise hydrophilic and hydrophobic blocks whereby the hydrophobic blocks comprise a biodegradable polyesteramide based on alpha-amino acids, diols, aliphatic dicarboxylic acids and optionally diamines whereby at least one of the dicarboxylic acids, diols or diamines comprises disulphide linkages.

Abstract: A curable isocyanate free formulation for preparing a polyurethane foam. The formulation includes a compound A chosen from multifunctional cyclic carbonates of a formula (I) or a mixture thereof, a compound B chosen from multifunctional cyclic carbonates containing oxyalkylene groups —OR3- of a formula (II) or a mixture thereof, a compound C chosen from multifunctional amines of a formula (III) or a mixture thereof and a compound D chosen from non-reactive blowing agents, as well as a process for preparing a non-isocyanate polyurethane foam, a foam obtainable by this process, compound B, a mixture of compounds A and B, the use of compound B for enhancing the solubility of a non-reactive blowing agent in a compound A and a foamable system having a first part A containing compound A and compound B and a second part B containing compound C, wherein part A and part B are preferably physically separated.

Abstract: The present invention relates to a method for manufacturing a polyarylene sulfide resin comprising: a step of reacting a poly(arylenesulfonium salt) having a constitutional unit represented by the following formula (1) with an aliphatic amide compound to obtain a polyarylene sulfide resin having a constitutional unit represented by the following formula (2): wherein R1 represents a direct bond, —Ar2—, —Ar2—S— or —Ar2—O—; Ar1 and Ar2 each represent an arylene group optionally having a functional group as a substituent; R2 represents an alkyl group having 1 to 10 carbon atoms or an aromatic group optionally having an alkyl group having 1 to 10 carbon atoms as a substituent; and X? represents an anion, wherein R1 and Ar1 are the same as described above.