Abstract: A wearable apparatus and a photoplethysmograph (PPG) sensor unit are provided. The wearable apparatus includes a wearable holder and a physiological information measurement module configured to the wearable holder. The physiological information measurement module includes a circuit board, an electrocardiograph (ECG) sensor unit and a PPG sensor unit. The PPG sensor unit is disposed on the circuit board and adapted to be used in conjunction with the ECG sensor unit electrically connected to a first pad and a second pad on the circuit board. The PPG sensor unit includes a grid having a plurality of accommodating spaces, a lighting element arranged in one of the accommodating spaces, and a photo sensor arranged in another accommodating space. The grid includes an inner conductive contact portion exposed from the wearable holder, facing an inner side of the wearable holder and electrically connected to the second pad.

Abstract: An electrophysiologic catheter with a distal electrode assembly carrying very closely-spaced bipole microelectrodes on a plurality of divergent spines that can flexibly spread over tissue surface area minimized detection of undesirable noise, including far-field signals. Each spine has a flexible microelectrode panel having a substrate, at least one pair of microelectrodes, a trace for each microelectrode, and a soldering pad. Adjacent microelectrodes of a bipole pair are separated by a space gap distance ranging between about 50-300 microns. Each microelectrode may have a width of about 200 or 300 microns.

Abstract: Disclosed herein are techniques for graphically indicating aspects of rotors (such as pivot points of rotors) associated with atrial or ventricular fibrillation. Embodiments can include receiving, using a processor, an electrogram for each of a plurality of spatial locations in a heart, each electrogram comprising time series data including a plurality of electrical potential readings over time. Embodiments can also include generating, from the time series data, one or more of multi-scale frequency (MSF), kurtosis, empirical mode decomposition (EMD), and multi-scale entropy (MSE) datasets, each dataset including a plurality of respective values or levels corresponding to the plurality of spatial locations in the heart.

Abstract: A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram.

Abstract: A biomedical electrode structure is presented. The electrode structure comprises a contact member having a tissue interfacing face for contacting a tissue surface, and an opposite electrical coupling face; at least a first electrically conductive surface disposed within said tissue interfacing face, and being configured to electrically couple to a portion of the contacted tissue; and at least two electrical connectors mounted in a spaced apart relationship on said electrical coupling face and electrically coupled to different regions of said electrically conductive surface for allowing measurement of at least one electrical property of at least a portion of said at least first electrically conductive surface residing therebetween.

Abstract: A brain mapping system includes a brain signal acquisition device for collecting brain signals corresponding to different locations of the brain, a stimulator for generating a stimulus based upon a pseudorandom sequence, and a processor for segmenting the brain signals into a plurality of epochs and correlating features extracted from the epochs with the pseudorandom sequence to generate correlation functions, wherein a brain map is constructed by the correlation functions.

Abstract: A method for detecting a stimulus pulse by using two or more electrical signals derived from a living body, the method comprising the following steps: (a) for each electrical signal, digitizing the signal with an analog-to-digital converter to produce a sampled signal Sk; (b) for each signal Sk at a sample time ti, computing a primary difference ?kp(ti)=abs[Sk(ti)?Sk(ti?p)]; (c) determining the minimum value of all of the computed differences, such minimum being a detector output D(ti); (d) comparing the detector output D(ti) with a detection threshold; and (e) indicating that a stimulus pulse has been detected when the detector output D(ti) is above the detection threshold.

Abstract: In various examples, an apparatus includes an apparatus configured for implantation within a body of a patient. The apparatus, in some examples, includes a housing. At least one antenna extends from the housing, the antenna being flexible such that the antenna conforms to the body of the patient. In some examples, the apparatus includes at least three electrodes, wherein at least a first electrode is disposed on the antenna and at least a second electrode is disposed on the housing. The at least three electrodes are disposed in a non-linear configuration, allowing for differential processing of signals recorded by the at least three electrodes.

Abstract: In a biological signal measurement system of this invention, biological digital data is generated from a biological signal measured by a biological signal measurement apparatus, and first feature amount data extracted from the biological digital data and downsized biological digital data are transmitted to a portable terminal. In a biological information measurement apparatus of this invention, biological feature amount data is extracted from measured biological waveform data, and at least one of the biological waveform data and the biological feature amount data is transmitted to an external device. It is possible to provide a biological signal measurement system capable of continuously measuring a biological signal for a long time without disturbing daily life and provide a biological information measurement apparatus capable of implementing downsizing and long life of a battery.

Abstract: A medical system including electrodes for acquiring electroencephalography (EEG) signals, amplifiers to amplify the EEG signals, an analog-to-digital converter to generate digitalized EEG data from the EEG signals, and a processor for processing the digitalized EEG data to generate a indication of neurological or psychological symptom based on a combination selected among spectral, temporal, and spatial features of the digitalized EEG data. The medical system further including a transcranial electrical stimulator that regulates stimulation frequency, intensity, or polarity according to the indication.

Abstract: Disclosed are a method and system for brain activity detection. The method is: performing multi-channel synchronous collections of brain electrical signals and cerebral cortex blood oxygen signals simultaneously, and ensuring synchronicity of the collected signals among channels, and collecting said brain electrical signals and said cerebral cortex blood oxygen signals of all locations at the same time.

Abstract: A magnetic resonance imaging (MRI) system for infants and children and imaging method thereof are disclosed. The system includes: a base; a housing, with a bottom fixed to the base; a monitoring shield, pivotably connected to the top of the housing; a pair of open magnets, which are spaced apart from each other and fixed to the base by a magnet holder such that an imaging area is defined between them; an operating table, fixed in the imaging area; an incubator, movably connected to the operating table and configured to house an infant or child and to adjust the position of the infant or child in the imaging area. The monitoring shield has a closed configuration and an open configuration. In the closed configuration of the monitoring shield, the magnet holder, the open magnet, the operating table and the incubator are all situated within a space delimited by the base, the housing and the monitoring shield.

Abstract: The present disclosure relates to computerized systems and methods for determining the location and orientation of implanted devices. Consistent with some embodiments, power levels of near-field signals are backscattered from an implanted device. The backscattered near-field signals may be detected by an ex-vivo antenna array. The determined power levels may be used to identify candidate location and orientation combinations based on a data set. The data set may be generated by calibrating the antenna array to the implanted device. A candidate location and orientation combination among the identified candidate combinations may be selected as the location and orientation of the implanted device.

Abstract: The present disclosure is directed to a method of determining a position of a medical instrument. The method may include inserting a first material into a body and adjacent to the medical instrument, analyzing at least one characteristic of the inserted first material, and determining the position of the medical instrument based on the analysis of the at least one characteristic.

Abstract: A breath component measurement apparatus includes a breath residence case. The breath residence case includes a container in the shape of a rectangular parallelepiped, an intake pipe in the shape of a circular tube which is provided at the center of a front face of the container, a pump which is formed over the whole right side surface of the container, a sensor storage unit in the shape of a circular tube which is provided at the center of a bottom surface of the container, a gas sensor which has the shape of a circular column and is stored in the sensor storage unit, a disk-shaped piezoelectric element which is supported by a groove in a slot, the slot that is formed on a left side surface of the container and has the groove supporting the piezoelectric element, and an exhaust port.

Abstract: A breath capture device for determining the concentration of acetone in a breath sample from a user. In some embodiments, the device includes a controller programmed to use stored data to control flow of a breath sample into an analysis chamber as the user exhales into a port. In other embodiments, the device includes a switch responsive to an action by the user that is operable between a first orientation in which breath entering the port preferentially travels through a second flow path and a second orientation in which breath entering the port preferentially travels through a first flow path. In still other embodiments, the device includes a flow regulator both responsive to user action and operable from a first position in which breath entering a port preferentially travels through a second flow path to a second position in which breath entering the port preferentially travels through a first flow path.

Abstract: A system and related devices for continuous and real-time monitoring and detection of head impact and corresponding trauma. The system may include a passive sensor mounted to a subject's tooth using dental hardware or adhesive so as to harness the firm coupling between the subject's tooth and cranium. With such firm coupling established, the impact data measured by the tooth-mounted sensor can be manipulated, through the use of a transfer function, by external processors to determine and communicate the impact experienced by the subject's head. The system is configured for use with an external power source whereby the passive tooth-mounted sensor is activated by means of a wireless transfer circuit such as an inductive power transfer circuit or an ultrasound power transfer circuit. The wireless activation of the powerless interior sensor system provides compatibility with multiple external power configurations, thereby enabling efficacious and continuous monitoring of the subject.

Abstract: Methods, systems, and devices for predicting bed-exit of a patient are described. Methods may include receiving pressure data from a pressure sensor disposed under the patient, receiving accelerometry data from an accelerometer coupled with the patient, detecting movement of the patient based at least in part on the pressure data and the accelerometry data, and determining whether the detected movement is indicative of bed-exit based at least in part on the detected movement. Systems may include a pressure sensor configured to collect pressure data associated with movement of the patient, an accelerometer configured to collect accelerometry data associated with movement of the patient, and a central aggregator configured to determine whether the movement of the patient is indicative of bed-exit based at least in part on the collected pressure data and the collected accelerometry data.

Abstract: An analyzing system and a method for evaluating calorie consumption by detecting the intensity of wireless signal are provided. The analyzing system includes a wireless receiving device, a processor and a calorie consumption computing device. The wireless receiving device receives a first wireless signal emitted from a first wireless transmitting device. The wireless receiving device detects a first intensity of the first wireless signal at a first time, and detects a second intensity of the first wireless signal at a second time. The processor obtains a motion information corresponding from the first time to the second time according to the first intensity of the first wireless signal and the second intensity of the first wireless signal. The calorie consumption computing device generates a calorie consumption according to the motion information.

Abstract: Activities, actions and events during user performance of physical activity may be detected using various algorithms and templates. Templates may include an arrangement of one or more states that may identify particular event types and timing between events. Templates may be specific to a particular type of activity (e.g., types of sports, drills, events, etc.), user, terrain, time of day and the like.

Abstract: The present invention relates to a device and method for determining vital sign information of a subject (2).

Abstract: The invention provides systems and methods for tissue-mounted photonics. Devices of some embodiments implement photonic sensing and actuation in flexible and/stretchable device architectures compatible with achieving long term, mechanically robust conformal integration with a range of tissue classes, including in vivo biometric sensing for internal and external tissues. Tissue-mounted photonic systems of some embodiments include colorimetric, fluorometric and/or spectroscopic photonics sensors provided in pixelated array formats on soft, elastomeric substrates to achieve spatially and/or or temporally resolved sensing of tissue and/or environmental properties, while minimize adverse physical effects to the tissue. Tissue-mounted photonic systems of some embodiments enable flexible passive or active optical sensing modalities, including sensing compatible with optical readout using a mobile electronic devices such as a mobile phone or tablet computer.

Abstract: Methods and apparatuses for determining an analyte value are disclosed.

Abstract: Methods for data acquisition and processing of magnetic resonance (MR) imaging to obtain the oxygen saturation (O2sat) of blood using a relationship between transverse relaxation time (T2) of blood and oxygen saturation. The method includes obtaining multiple images at various T2 preparation times. Next, non-linear curve fitting may be used to solve for arterial or venous O2sat. The disclosure provides a calibration-free method for accurate quantitative assessment of blood in the heart and deep vessels, even in locations having limited accessibility with other diagnostic techniques.

Abstract: The disclosure provides methods and systems for determining tissue oxygenation. An electronic device obtains a data set including a plurality of images of a tissue of interest, each resolved at a different spectral band. Spectral analysis is performed, upon image registration, at a plurality of points in a two-dimensional area of the images of the tissue. The spectral analysis including determining approximate values of oxyhemoglobin levels and deoxyhemoglobin levels at each respective point in the plurality of points. The predetermined set of eight to twelve spectral bands includes spectral bands that provide improved methods for measuring tissue oxygenation.

Abstract: A compact perfusion scanner and method of characterizing tissue health status are disclosed that incorporate pressure sensing components in conjunction with the optical sensors to monitor the level of applied pressure on target tissue for precise skin/tissue blood perfusion measurements and oximetry. The systems and methods allow perfusion imaging and perfusion mapping (geometric and temporal), signal processing and pattern recognition, noise cancelling and data fusion of perfusion data, scanner position and pressure readings.

Abstract: An arm mountable portable patient monitoring device configured to receive physiological information from a plurality of sensors attached to a patient via wired connections for on-patient monitoring of parameter measurements and wireless transmission of parameter measurements to separate monitoring devices. The arm mountable portable patient monitoring device includes a housing, a strap, a display, a first sensor port positioned on a first side of the housing configured to face toward a hand of the patient when the housing is secured to the arm of the patient, second and third sensor ports configured to receive signals from additional sensor arrangements via a wired connections, one or more signal processing arrangements configured to cause to be displayed measurements of oxygen saturation and pulse rate, and a transmitter configured to wirelessly transmit information indicative of the measurements of oxygen saturation and pulse rate to a separate monitoring device.

Abstract: A device includes a housing, an emitter, a detector, and a processor. The housing has a body contact surface. The emitter is coupled to the housing and has an emission surface and has an electrical terminal. The emission surface is configured to emit light proximate the body contact surface in response to a signal applied to the electrical terminal. The detector is coupled to the housing. The detector has a sense surface and an output terminal. The detector is configured to provide an output signal on the output terminal in response to light detected at the sensor surface. The processor is configured to implement an algorithm to determine a tissue site based on the emitted light and based on the detected light.

Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood from subjects. In one aspect, the present invention is directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a substance transfer component (for example, one or more needles or microneedles) and a reduced pressure or vacuum chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some embodiments, the device may contain a “snap dome” or other deformable structure, which may be used, at least in part, to urge or move needles or other suitable substance transfer components into the skin of a subject. In some cases, for example, the device may contain a flexible concave member and a needle mechanically coupled to the flexible concave member such that the needle may be urged or moved into the skin using the flexible concave member.

Abstract: Apparatus (11) for detecting, diagnosing and exercising an individual's functionalities, comprising: a plurality of emitters (15) emitting optical stimuli perceivable by an individual (13); a control unit (19) adapted to control the activation of the emitters (15) and programmed for activating the emitters (15) according to at least one parameter (P) and in accordance with a predetermined sequence (Q); a memory unit (21) in which predetermined sequences (Q) for the activation of the emitters (15) are stored, each sequence (Q) being identified by a univocal sequence reference and comprising the references of a group of emitters (15) belonging to the plurality of emitters and arranged along a path corresponding to the movement to be induced in the eyes of the individual (13); a sensor (31) “Eyetracker” capable of generating an electrical signal indicative of eye movements for detecting eye movements of an individual (13); a processing unit (25) operationally connected to the control unit (19) and programmed for

Abstract: The present application describes a urine sensing probe and a system for detecting urine. The urine sensing probe includes a needle having a tubular portion and one or more optical fibers positioned within the needle. The one or more optical fibers have a distal surface that is oriented towards a beveled distal section of the needle and is oriented to one of its lateral sides. The distal surface of the one or more optical fibers ranges from about 90 to a critical angle with respect to a vertical axis of the needle. The present application also describes a system for sensing urine including a urine sensing probe.

Abstract: A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.

Abstract: Systems and methods for monitoring the onset or occurrence of labor contractions and detecting or estimating labor in a pregnant female are provided.

Abstract: A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.

Abstract: Systems and methods for discriminating between malignant and benign pigmented skin lesions based on optical analysis using spatial distribution maps, morphological parameters, and additional diagnostic parameters derived from images of tissue lesions. A handheld optical transfer diagnosis device is disclosed capable of capturing a series of reflectance images of a skin lesion at a variety of angles of illumination and observation.

Abstract: A pressure ulcer detection system includes a support surface assembly including a transparent window, a signal generator/receiver, and an optical fiber embedded at least in part in the support surface assembly. The fiber conveys outgoing radiation from the signal generator/receiver to the window thereby illuminating a tissue site which overlies the window and conveys incoming radiation reflected from the tissue site and through the window back to the generator/receiver. The system also includes a controller in communication with the signal generator/receiver. The controller comprises a processor adapted to assess health status of tissue at the tissue site based on a property of at least one of the outgoing radiation and the incoming radiation, and to communicate an outcome of the assessment to a destination.

Abstract: An intra-oral imaging apparatus for obtaining a contour image of a tooth has a fringe pattern generator energizable to emit a fringe pattern illumination. The fringe pattern generator has (i) at least one structured light source that is energizable to emit a patterned light beam; (ii) at least one reflective element in the path of the emitted patterned light beam and actuable to rotate about an axis to scan the emitted patterned light beam along a tooth surface as fringe pattern illumination. A detector is configured to acquire one or more images of the fringe pattern illumination from the tooth surface. A control logic processor is configured to control the fringe pattern generator for illuminating the tooth and to obtain and process the one or more images acquired by the detector.

Abstract: A wearable device or apparatus is used for monitoring biometric data of a user and enabling biofeedback indications in response to biometric data received. In one embodiment, the wearable device includes at least one sensor, a button, at least one processor having a memory unit coupled to the at least one sensor and a feedback mechanism. The feedback mechanism can include a biofeedback indicator.

Abstract: Methods for combining anatomical data and physiological data on a single image are provided. The methods include obtaining an image, for example, a raw near-infrared (NIR) image or a visible image, of a sample. The image of the sample includes anatomical structure of the sample. A physiologic map of blood flow and perfusion of the sample is obtained. The anatomical structure of the image and the physiologic map of the sample are combined into a single image of the sample. The single image of the sample displays anatomy and physiology of the sample in the single image in real time. Related systems and computer program products are also provided.

Abstract: A method, a wearable device, and an apparatus for monitoring sleep of a user are provided. The method includes: determining an activity amount of a user based on multi-axial acceleration data received by the wearable device in a time period, in which the multi-axial acceleration data includes acceleration data in multiple axes; if the activity amount is smaller than a first threshold, determining a microactivity feature value using the multi-axial acceleration data and predetermined weights; and determining a microactivity state for the user in the time period based on the microactivity feature value, in which the activity amount of the user is substantially zero in the microactivity state.

Abstract: Disclosed is a human body frequency diagnostic analysis apparatus including a transceiver with an end connected to a human head and driven to transmit a transmission frequency and drive the human head to feed back a feedback frequency, a detection unit connected to the transceiver for driving the transceiver to transmit the transmission frequency and receive the feedback frequency, and a control unit connected to the detection unit for controlling the detection unit and includes a computing unit for computing and comparing the transmission frequency with the feedback frequency to generate a dual line spectrum, a database for comparing the dual line spectrum to generate detected information, and a screen for displaying the dual line spectrum and the detected information. A maximum drop value detected in a frequency section of the dual line spectrum indicates an imbalance of a human body frequency.

Abstract: The present disclosure discloses a control method of a wearable device execution module and a wearable device. The control method includes detecting at least one touch position and determining a set consisting of the detected at least one touch position as a current touch position set, the at least one touch position being a position at a predetermined touch sensing area; determining an execution module corresponding to the current touch position set as a current execution module based on a correspondence between predetermined touch position sets and execution modules and generating a control command; and transmitting the control command to the current execution module so that the current execution module executes the control command.

Abstract: A sensor device which is suitable for receiving and transmitting signals and can be placed on a test person's head, includes a sensor device housing having a signal pin on its distal side for receiving a signal and a connection on its proximal side for the signal transmission of a signal received by the signal pin. A sensor device holder has an axial through opening in which the sensor device housing is disposed so as to be steplessly axially displaceable. When the sensor device housing is axially displaced relative to the sensor device holder, the sensor device housing does not change its radial orientation. A cap having a plurality of sensor devices is also provided.

Abstract: A system and method for monitoring a health status of a subject. The system comprises: a medical device implantable in the subject and having a passage or compartment through which blood flows through; a sensor device embedded at or near a surface of said passage within said medical device for generating signals suitable for measuring a Doppler shift effect occurring within said passage; and a control device coupled to said sensor device for measuring a liquid blood flow rate within said passage based on sensor generated signals outputs. The embedded sensor device comprises a first piezo-electric element configured to generate an acoustic excitation signal and a second piezo-electric element configured to receive said acoustic excitation signal. The second piezo-electric element emits a signal responsive to said acoustic excitation signal. Control device in real time compares a generated output signal with the input excitation signal to determine a Doppler frequency shift measurement.

Abstract: A smart patch including multi-component strands integrated into clothing or other textiles where the strands of the smart patch include sensory elements that can simultaneously measure tactile forces, moisture/wetness, and other signals, such as biopotentials. A sensing system comprising: a first set of strands including a plurality of first multi-component strands, each of the first multi-component strands including a conductive portion and a non-conductive portion; and a second set of strands including a plurality of second multi-component strands, each of the second multicomponent strands including a conductive portion and a non-conductive portion, and a plurality of third multi-component strands, each of the third multicomponent strands including a conductive portion and a non-conductive portion, the third multi-component strands being different than the first multi-component strands and the second multi-component strands.

Abstract: The invention provides a physiological probe that comfortably attaches to the base of the patient's thumb, thereby freeing up their fingers for conventional activities in a hospital, such as reading and eating. The probe, which comprises a separate cradle module and sensor module, secures to the thumb and measures time-dependent signals corresponding to LEDs operating near 660 and 905 nm. The cradle module, which contains elements subject to wear, is preferably provided as a disposable unit.

Abstract: A temperature sensing patch that is easy to use and capable of efficiently monitoring temperature change in human, body for a long time, capable of being used with a reading device, comprising the temperature sensing patch configured to attach to human skin, comprising a housing, a circuit board, a temperature sensing unit electrically connected with the circuit board, a battery, a processor chip, at least a memory unit, and at least a port; wherein the processor chip can automatically turn on the temperature sensing patch and reset the previous data by a predetermined program, rather than through a manual switch, when the temperature sensing patch is removed from the reading device.

Abstract: Devices and systems for tissue engagement and methods of using the same.

Abstract: A method and apparatus for mapping a location of a point within the body is disclosed. A plurality of positional reference nodes are determined, each aligned on a first element. A second element is mapped with reference to the plurality of reference nodes to determine the relative location of a point on the second element.

Abstract: A method for the validation of physiological data, acquired in two or more parts of the human body by sensors connected to a medical device, for the statistical validation of the relationship among the signals retrieved by the medical devices, in order to select information that increases the accuracy of the study being carried out, with a high statistical certainty. The purpose of the actual invention is to make this statistically validated data available for use by protocols or reference values, according to the field of application, which increase accuracy of the studies being carried out.