Abstract: A method may include displaying to a user an interface at which the user inputs a fear of hypoglycemia index (FHI), the FHI corresponding to an acceptable probability of a blood glucose level being below a threshold blood glucose level. The method may also include receiving blood glucose data for a person with diabetes (PWD). The method may additionally include calculating a probability of the PWD having a blood glucose level below the threshold blood glucose level based on the variability of the received blood glucose data. The method may also include setting one or more target blood glucose levels to align the probability of the PWD having a blood glucose level below the threshold blood glucose level with the acceptable probability associated with the user input FHI. The method may additionally include delivering insulin, using the insulin delivery device, based on the target blood glucose level.

Abstract: A telescoping portable drug mixing and delivery device configured to store a dry medication separately from a liquid component, wherein a tensile force applied between the housing and a cap opens a valve and causes displacement of a fluid from a first chamber to a second chamber while simultaneously mixing the fluid with a dry medicament prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a sliding valve and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: An article is described including an article surface, a primer coating of SiOx, SiOxCy or SiNxCy applied to the article surface, and optionally a deposit of lubricant applied to the primer coating or layer. The primer coating of SiOx, SiOxCy or SiNxCy is applied by PECVD of an organosiloxane precursor. A deposit of lubricant is applied to the primer coating or layer. The primer coating improves the adhesion or wetting of the lubricant on the surface to be lubricated, as well as the recovery of the liquid contained in the vessel. Examples of such an article are a prefilled syringe having a barrel with a lubricated interior portion and a plunger tip that slides along it. Another example of such an article is a vial having a lubricated opening to receive a septum. Another aspect of the invention is a method of making such an article.

Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

Abstract: A dispensing device (1) for dispensing a fluid, preferably an injection syringe. The device comprises a main body (2) which has a longitudinal axis (A) and has a receiving space (3) for receiving the fluid, and a connection channel (4) communicates with the receiving space. The connection channel opens on a valve face (5) of the main body. The device comprises a movable flow control element (6) arranged on the main body. The flow control element has one or more flow channels (7) which open on a valve face (8) of the flow control element. The connection channel of the main body and the flow channels of the flow control element are fluidically connected to each other by relative movement of main body and flow control element. A sealing element (10) is arranged between the valve face of the main body and the valve face of the flow control element.

Abstract: An injection device for the delivery of medicament is disclosed having an indicator for providing an activation indication. The device includes a housing; a plunger slidably mounted within the housing; an actuation mechanism configured, in use, to move the plunger forward relative to a syringe so as to express medicament from the syringe. The device also includes an indicator element responsive to the forward movement of the plunger and configured to provide an audible and/or tactile and/or visual indication when the plunger reaches or approaches its forward position. The plunger includes an elongate shaft formed of at least two telescopic sections. The actuation mechanism acts on the plunger, in use, to expand the telescopic sections and to sequentially move each of the telescopic sections forwardly within the housing. The indicator element is arranged to be responsive to the forward movement of the trailing telescopic section.

Abstract: A syringe is to be obtained by using PTFE for a gasket main body that makes a direct contact with an injection solution and using a slidable silicone rubber at a portion that does not make contact with the injection solution. A syringe A includes a syringe barrel 1, a gasket 10 press-fitted within the syringe barrel 1, and a plunger rod 5 mounted in the gasket 10. In the gasket 10, a concaved groove 18 is formed over the whole circumference of a slide-contact surface 11 of a main body portion 26 that is formed of a rigid plastic having a drug solution-resistant property against a drug solution 30 to be loaded in the syringe barrel 1 and that is configured to slidingly contact an inner circumferential surface 2 of the syringe barrel 1.

Abstract: Add-on module (100) for logging the value of an expelled dose from a pen-type drug injector (200), comprising a magnetic sensor system comprising first and second sensor means (745/746) as well as a mechanical dose setting and expelling mechanism comprising a magnetic clutch element (240/740) which rotates during drug expelling. The system further comprises processor means configured to determine (i) on the basis of measured values from the first sensor means, a rotational position of the clutch element, (ii) on the basis of measured values from the second sensor means, a high-speed condition in which the rotational speed of the clutch element exceeds a given threshold level, and (iii) indicate an error state if the high-speed condition is detected.

Abstract: Improved systems and methods for medicine delivery, and in particular, improved insulin pen needles and related devices are provided. Smart injection devices record and transfer data including medicine level, delivered dose, dose confirmation, and dose time and date. Additional data captured may include glucose concentration, insulin level, carbohydrates ingested, stress level, exercise, blood pressure, and glucose high and low excursion events. Various means of data collection and analysis are provided and systems can identify and flag patients who require intervention. Smart sleeves and add sensing capability to standard insulin pens. Pen needles are provided with sensing capability to confirm and measure doses delivered by insulin pen. A two-part pen cap include a primary sleeve that connects to the insulin pen and an end cap that provides for capturing the time of dose delivery, and monitoring the hold time for a dose delivery after plunger movement.

Abstract: A needle assembly is disclosed, for use with an injection device. The needle assembly comprises a needle hub (20) having a needle (22) and a needle shield (40) arranged for relative axial movement with respect to the needle hub, between a retracted position in which the tip of the needle projects beyond a forward end of the shield and an extended position in which the tip of the needle does not project beyond the forward end of the shield. The needle shield (40) is axially biased towards the extended position. The needle shield (40) is further arranged to be torsionally biased for relative rotational movement with respect to the needle hub (20).

Abstract: An apparatus includes a container, a needle, and an actuation assembly. The container contains a dose of a naloxone composition having a delivered volume of at least about 0.34 mL. The actuation assembly includes an energy storage member that produces a force on a movable member to move the needle and to deliver the dose of the naloxone composition. The 90% confidence interval of at least one of the relative mean maximum naloxone plasma concentration after dose delivery into the body (Cmax), time to reach the maximum naloxone plasma concentration (Tmax), area under the plasma concentration-time curve from pre-dose (time 0) extrapolated to infinity (AUC0-?), or area under the plasma concentration-time curve from pre-dose (time 0) to the time of the last quantifiable concentration (Tlast) (AUC0-t) of the delivered dose to a delivered dose of a corresponding naloxone composition delivered via a manually-actuated syringe is within 80% to 125%.

Abstract: Embodiments of a retractable syringe assembly are provided that include a single syringe barrel configuration and dual syringe barrel configuration. In one or more embodiments, the assemblies include a barrel having a dividing wall to divide the chamber to define a fluid chamber having a first cross-sectional width for retaining fluid and a needle chamber for housing a needle hub assembly. The assemblies include a projection extending radially outwardly from the plunger rod to interact with a ramped portion of the dividing wall to cause the needle cannula to retract and be housed within the needle chamber.

Abstract: A needle tip (22) for being connected and disconnected in use from a needle tip support (16), comprises a needle (24) having a forward end and a rearward end and, a connector secured to the needle intermediate its ends. The connector comprises two arms (28) each extending outwardly and rearwardly relative to the needle (16) and configured to be coupled and uncoupled in use from said needle tip support, and the arms are disposed on opposite sides of the needle. Also disclosed are arrangements for storing, dispensing and later disposing such needle tips, as well as coupling interfaces between the needle tip and a needle support cap to which it is fitted in use.

Abstract: The present disclosure is concerned with a device for facilitating a subcutaneous injection and a process for administering the subcutaneous injection. The device has a peripheral frame and an injection needle or an aperture in a central portion of the frame adapted to hold an injection needle. The peripheral frame has an arm or arms adapted to contact the skin at points distant enough from each other to allow the arms or arm to penetrate into the skin a distance greater than the thickness of the skin, a central portion which joins the arms above the terminal portions or portion and an injection needle affixed to the central portion, facing in the same direction as the penetration ends of the arms or an aperture in the central portion adapted to hold an injection needle facing in the same direction as the penetration ends of the arms.

Abstract: A method of manufacturing a flowable and dispersible powder includes solubilizing a lipophilic substance in a terpene to form a mixture and treating the mixture to form a nanoemulsion dispersed in an aqueous solution. The aqueous solution includes at least one functional excipient. The nanoemulsion is then spray dried, thereby evaporating first the aqueous portion and then the terpene to form a dry powder formed from solid particles comprising the lipophilic substance.

Abstract: The invention relates to a fluid reservoir (2) for an aerosol generator (50), the fluid reservoir (2) comprising a fluid chamber (4) for receiving a fluid (6), an opening (8) for guiding the fluid (6) received in the fluid chamber (4) outside the fluid chamber (4), and a collar portion (10) surrounding the opening (8) and extending into the fluid chamber (4). A first portion (12) of the fluid chamber (4) extends along the length of the collar portion (10) in a height direction (H) of the fluid chamber (4), A second portion (14) of the fluid chamber (4) is arranged adjacent to the first portion (12) in the height direction (H) of the fluid chamber (4). A lateral extension of the first portion (12) in the directions perpendicular to the height direction (H) of the fluid chamber (4) is smaller than a lateral extension of the second portion (14) in the directions perpendicular to the height direction (H) of the fluid chamber (4).

Abstract: The present invention provides an end fitting (1) for a spacer assembly and a spacer assembly having such an end fitting for fitting to a drug delivery inhaler device (21). The spacer assembly has a spacer body (17) with opposing first and second axial ends. The end fitting comprises an end panel having an upper end face (2) and a lower end face (3). A lower annular recess (4) is provided on the lower end face for receiving the first axial end (18) of the spacer body in a first configuration. An upper annular recess (12) is provided on the upper end face for receiving the second axial end (20) of the spacer body in a second configuration. The end fitting further comprises an open-ended tubular projection (16) extending from the upper end face and an aperture extending through the end panel from the lower end face to the tubular projection.

Abstract: Dispensing apparatus is provided for delivering and/or dispensing a pre-determined amount of a product in use. The apparatus includes dispensing means having inlet means for allowing product to enter the dispensing means in use, outlet means for allowing product containable within the dispensing means in use to be dispensed therefrom during a dispensing action of the apparatus, and channel means provided between the inlet means and the outlet means for allowing product to move between the inlet means and the outlet means in use. Recess means are defined in the channel means. The dimensions of the recess means define or substantially define the pie-determined amount of product that can be delivered through the outlet means for each dispensing action of the apparatus.

Abstract: In one embodiment, a method for categorizing a state of a subject undergoing therapy from a mechanical ventilator is disclosed. The method includes receiving, at a device, one or more cardiovascular measurements regarding the subject, a respiratory rate from the ventilator, a carbon dioxide (CO2) measurement regarding the subject, and a tidal volume value from the ventilator. The method also includes selecting, by the device, a ventilation category based on the one or more cardiovascular measurements, the respiratory rate, the CO2 measurement, and the tidal volume value. The method further includes retrieving, by the device, an alert that is associated with the selected ventilation category. The method additionally includes providing, by the device, the alert to a user interface device.

Abstract: Present invention is a oral airway with a flexible air connector and tubing built into the trachea tube distal end. Additional access channels are also provided.

Abstract: A method for intubation of a patient comprising: providing an LMA and an endotracheal tube, wherein the endotracheal tube comprises a visualization device and wherein the endotracheal tube is adapted for passing through the LMA; positioning the LMA in the patient; and guiding the endotracheal tube with the aid of the visualization device through the LMA for positioning in the trachea of the patient. The method preferably further comprises removing the LMA from the patient following the positioning of the endotracheal tube while leaving the endotracheal tube in position.

Abstract: This invention is an improved assembly for intubation comprising: a cricothyroidotomy tube that can receive a malleable bougie allowing the cricothyroidotomy tube to take the shape of the bougie so that the cricothyroidotomy tube can be placed in a patient. A guide device can receive the bougie so that the bougie can be manipulated with the guide device to assist with insertion of the cricothyroidotomy tube in the patient. A bougie opening can be defined in the guide device for receiving a proximal end of the bougie to position the proximal end out of the way of a care giver to reduce interference that can be caused by the proximal end. Markings on the bougie can illustrate where to positioned the bougie to allow a predetermined amount of the bougie to extend from the cricothyroidotomy tube.

Abstract: Provided is a gas storing mask which, with a simple configuration, allows a reduction in feeling of discomfort given to a patient. An oxygen delivering mask (1a) includes a first sheet (2) and a second sheet (3), oxygen supplied from outside the oxygen delivering mask (1a) being stored in a gas storing part (4) formed between the first sheet (2) and the second sheet (3).

Abstract: A mask system includes a frame (20) adapted to attach headgear, a sealing arrangement (40) releasably connectable to the frame, and an elbow (70) provided to the sealing arrangement and adapted to be connected to an air delivery tube that delivers breathable gas to the patient. The sealing arrangement defines a breathing chamber and is adapted to form a seal with the patient's face. The sealing arrangement includes structure (50) to establish a positive connection with the frame and with the elbow.

Abstract: A nasal cannula including a manifold having a delivery channel and a collection channel fluidly connected to a delivery nasal prong for delivering a gas to be inhaled from a patient's nose and to a collection prong for collecting gas exhaled from the patient's nose. The prongs are composed of a resilient material having sufficient memory that allows the prongs to be resiliently spread apart to be inserted into the respective nares of the patient's nose and when released, gently grasp the columella of the patient's nose to secure the cannula in position. The prongs are oriented leftwardly or rightwardly of the channels so that the right or left portions of the patient's face remain unobscured during surgery.

Abstract: A pressure support system that comprises a patient circuit, a docking assembly, and a tank. The patient circuit delivers a pressurized flow of breathable gas to a patient. The docking assembly has an inlet and an outlet that is adapted to receive the pressurized flow of breathable gas, and is also adapted to be connected with the patient circuit. The tank is constructed and arranged to be removably connected with the docking assembly, and enables the pressurized flow of breathable gas to pass therethrough. The tank is also adapted to contain a liquid such that a humidity level of the pressurized flow of breathable gas is elevated as the pressurized flow of breathable gas passes therethrough.

Abstract: A vent assembly for use with a mask assembly includes a first vent, a second vent and a selector to switch the flow of exhaled gas from a patient between the first and second vents.

Abstract: A breathing circuit for use in conjunction with a ventilator serving a mechanically-ventilated patient includes an expiratory gas airflow pathway; an inspiratory gas airflow pathway; and a gas mixing mechanism operable to mix inspiratory gas and expiratory gas in an amount sufficient to equilibrate the patient's PETCO2 and arterial PCO2 such that the patient's PETCO2 is a clinically reliable approximation of the patient's PaCO2.

Abstract: A bi-level positive airway pressure device includes a housing that has a patient port for connecting to an airway of a patient. Within the housing is a device that generates a positive airway pressure directed towards to patient port. Also within the housing is a system that detects exhalation (by a patient that is connected to the patient port) that enters into the patient port. Responsive to detecting exhalation, a blocking device occludes the device that generating positive airway pressure, thereby reducing or stopping the positive airway pressure. Upon the system detects abatement of exhalation, the blocking device is operated to no longer occlude the device for generating positive airway pressure, thereby providing positive airway pressure to the patient port.

Abstract: A lighting system for initiating change in a mammal's circadian or well-being state includes a computational unit configured to receive state information regarding the mammal's circadian or well-being state, and operational information from a light sensor with spectral and luminosity sensitivity. The computational unit is configured to compare the operational information with the state information, and on the basis of this comparison, the computational unit outputs a control signal to a light control unit which, in turn, adjusts a controllable light source to vary its light output so as to initiate the desired change in the mammal's circadian or well-being state.

Abstract: Medical device kits for use in placing, maintaining, altering, and/or removing medical devices in, on, and/or from the body of a patient are disclosed. Such medical device kits can include one or more wrap assemblies for use in the placement/maintenance procedure. In accordance with present embodiments, the one or more wrap assemblies of the medical device kit can include various features to assist the clinician performing the particular procedure. In one embodiment, a medical wrap assembly is disclosed, comprising a foldable wrap body that includes a front surface, wherein the front surface is configured to define a sterile field. A plurality of pockets is included on the front surface of the wrap body. The pockets are configured to contain therein a plurality of medical components. The medical components are arranged in the pockets in a predetermined order of use for the medical procedure.

Abstract: An arrangement adapted for enhanced continuous flow of urine in a catheterized patient, the arrangement comprising a catheter tube having an inner diameter of less than six millimeters, said tube having an inner surface which is hydrophobic at least along a first segment thereof and being adapted to provide a continuously negative fluid pressure therein.

Abstract: A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.

Abstract: Devices for transferring fluid to or from a subject include an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen. The devices also include an elongate needle having opposing proximal and distal ends. The elongate needle is configured so that the distal end of the needle extends out of the distal end of the cannula a suitable adjustable distance. The devices also include a housing with a length adjustment mechanism that adjusts a length between the tip of the needle and the distal end of the tubular cannula.

Abstract: A catheter hub for use with a medical device and a catheter, the hub includes a hub body defining a fluid passageway in communication with a first aperture. Optionally, the hub body defines a second aperture that intersects the first aperture. The hub body attaches to the catheter wherein the fluid passageway and the catheter are aligned for fluid flow therethrough. The first aperture extends from and communicates with the fluid passageway to an exterior surface of the hub body and the first aperture configured to receive the medical device. The second aperture extends from and communicates with the first aperture and the exterior surface. A sealing element is sized for and positioned in either the first or the second apertures. The sealing element is configured to receive the medical device and seal both of the first and the second apertures.

Abstract: Described are drainage catheter hub devices which seal the hub from leakage when connected to a catheter. The catheter hub includes a hub body having an aperture with a sealing element mounted therein and a fluid passageway that communicates with the aperture. The fluid passageway and sealing element are configured to receive a tension member. A lever arm attached to the hub body is operable to secure the position of the tension member in the sealing element in a locked position or allow movement of the tension member through the sealing element in an unlocked position. The lever arm is configured to engage and compress the sealing element to block fluid flow through the sealing element and the aperture when the lever arm is in any position. The hub body may include a centering tab to align the tension member along a longitudinal axis of the hub body.

Abstract: A system by which resource information relating to an insertable medical device, such as an intravascular catheter, can be identified by its source so as to be accessed by a practitioner, caregiver, or patient, is disclosed. In particular, a resource information key is included at a predetermined key location on or proximate to the medical device, wherein the key indicates the source of the resource information. In one example embodiment, therefore, an insertable medical device for establishing intravascular access to a patient, such as a peripherally inserted central catheter (“PICC”), is disclosed and comprises: an internal portion configured for intravascular insertion into the patient, and a portion external to the patient. The exterior portion of the PICC includes a resource information key that is positioned at a predetermined key location. The resource information key indicates a website where a user can acquire the resource information relating to the medical device.

Abstract: A medical treatment tool includes a bendable tube configured to be inserted into a body of a patient; an operating body disposed in the bendable tube and configured to cause bending of the bendable tube, the operating body including: a plurality of divided members that are divided from each other along axially extending edges of adjacent divided members, portions of the divided members forming a tubular structure, and an annular connecting portion, an outer surface of the annular connecting portion being continuous with outer surfaces of the divided members; and a cylindrical member located inside the operating body. Each divided member includes at least one cutout portion formed between the tubular structure and the annular connecting portion. The cylindrical member is in contact with inner surfaces of the divided members.

Abstract: A deflectable device, such as a catheter, is provided that includes a hinge that enhances the ability of the device to deflect or bend within a predetermined plane. The catheter comprises an elongated tubular catheter body having proximal and distal ends and at least one lumen extending therethrough. A distal segment is provided distal to the distal end of the catheter body. A tubular hinge is provided between the distal end of the catheter body and the proximal end of the distal segment. The hinge has an axis and at least one lumen extending therethrough. The tube includes at least one slot, and preferably a plurality of slots, extending part of the way through the hinge generally transverse to the axis of the hinge.

Abstract: A protective barrier is provided. The protective barrier includes an elongated tube, which may include a protective gasket shape or boxed shaped apparatus. The elongated tube includes an inner surface, an outer surface, a first rim forming an entrance and a second rim forming an exit. A length of the elongated tube is from the first rim to the second rim. Tape attaches the elongated tube to the user's skin at an entry point of the fluid conducting lines. A first side edge and a second side edge are formed along the length of the elongated tube, forming a slit. The first side edge and the second side edge are biased to overlap one another. A disinfectant layer such as an anti-bacterial, anti-viral, and/or anti-septic, is disposed on the inner surface of the elongated tube.

Abstract: The expandable sheath and system (10) for intravascular insertion of a medical implement includes a cannula (70) for entering a lumen of a vascular vessel of a patient, a guide wire (72) insertable into the lumen, an introducer and dilator (62) adapted to follow the guide wire (72) into the lumen, an expandable sheath (40) positioned on the introducer and dilator (62), with the expandable sheath (40) being adapted to be positioned in the vessel, and an extension collar (76). The medical implement is received within the vessel by passing through the sheath (40) upon separating the introducer and dilator (62) therefrom. In one embodiment, a linear array of perforations (50) formed through the expandable sheath (40) allow for expansion. Alternatively, an external slit (16) may be provided for selective expansion of the sheath (40).

Abstract: A medical instrument is that the first holding portion or the second holding portion is capable of moving so that a distance between a distal end of the first holding portion and a distal end of the second holding portion changes from a first dimension which is larger than a diameter of the wire to a second dimension which is smaller than the diameter of the wire and the space is formed by the first holding portion and the second holding portion such that the wire is capable of rotating about a line connecting a first contact point where the first protrusion portion contacts with the wire with a second contact point where the second protrusion portion contacts with the wire.

Abstract: The present disclosure concerns embodiments of multi-lumen cannulae that can be used in various different medical procedures. The multi-lumen cannulae can comprise an elongated body comprising multiple different ports that connect to the various different sidewall lumens contained within the elongated body. The multi-lumen cannulae can also comprise a central lumen that extends through the entire elongated body and can be fluidly connected to the various different sidewall lumens. The multi-lumen cannulae can further comprise two balloons on the exterior of the elongated body, which can be used to isolate the right atrium of a patient's heart.

Abstract: A balloon catheter assembly is provided with an outer catheter, an inner catheter, an outer adapter and a balloon, and is configured such that the balloon resides entirely within a predetermined volume having an outer diameter substantially equal to or less than the outside diameter of the distal end of the outer catheter when the balloon is in a deflated configuration. Methods of using and steering the catheter assemblies are also provided.

Abstract: A shunt including an implantable housing having a proximal end and a distal end. A pressure sensitive valve is contained within the housing at a position between the proximal end and the distal end, and the pressure sensitive valve is capable of controlling a flow of fluid between the fluid inlet port and the fluid outlet port. The shunt further including a sensor assembly fluidly coupled to the pressure sensitive valve, wherein the sensor assembly is mechanically actuated and capable of detecting the flow of fluid through the pressure sensitive valve. A condition of the shunt can be detected by detecting a flow of fluid through the shunt and generating a signal indicative of a period of fluid flow through the implantable shunt based on the detecting. The signal can be output to an external device capable of determining, from the signal, whether the shunt is malfunctioning.

Abstract: A method for treatment of COPD, hypertension, and left ventricular hypertrophy, and chronic hypoxia including creation of an artificial arterio-venous fistula and installation of a flow mediating device proximate the fistula. The flow mediating device is operated to limit flow as medically indicated to provide the optimum amount of bypass flow.

Abstract: Face soaking devices (devices) and methods of use are described and disclosed. In some embodiments the device may comprise a vessel and a vessel neck gasket. The vessel may be configured to hold a liquid to submerge a face of a user or a portion thereof. The vessel neck gasket may be (removably) joined to the vessel. The vessel neck gasket may be configured to comfortably accommodate a portion of the user's neck. In some embodiments, the device may comprise a breathing apparatus that may be in removable contact with: the vessel, with a head rest subassembly, and/or with the user. The breathing apparatus may be configured to permit the user to breathe while the user's face may be submerged within the liquid. When the vessel may be filled with the liquid to at least a sufficient level, the user may soak the face or the portion thereof, such that the skin being soaked receives a benefit.

Abstract: Method and device for treatment of a cutaneous surface or a mucous membrane. The device comprises a container, such as an aerosol can, for containing a composition comprising at least one refrigerant. The container has a container outlet and a valve communicating with the container outlet. An applicator is mounted or mountable to the container. The applicator comprises a heat exchanger, a contact surface and a dispensing channel between the container outlet and one or more applicator outlets arranged for wetting the contact surface. The dispensing channel defining a flow path crossing the heat exchanger. The contact surface can for example be formed by a non-porous layer, e.g. of plastic or rubber.

Abstract: A cosmetic applicator, comprising a sponge to absorb substance and prevent leakage thereof is provided herein. The sponge having an elastic open-cell of a three-dimensional membrane structure of elastic polymer and is double over molded in combination with the rigid plastic base. The sponge has predefined density enabling to absorb the substance and skin surface having predefined thickness to prevent a spontaneous release of the substance. The substance may be squeezed out of the sponge only when applying pressure on the sponge. A Radio Frequency Identification (RFID) tag is integrated to the rigid plastic base to allow information related storage.