Patents Issued in August 17, 2017
  • Publication number: 20170234845
    Abstract: A portable gas detecting and monitoring apparatus includes a case having a continuous sidewall including a first end closed a first end cap, and a second end closed by a second end cap connected sealably and removably to the continuous sidewall. The continuous sidewall is triangular between the closed end and the open having three sides and three corners, two of the three sides being straight and equal in length, one of the three sides being rounded, and each of the three corners being rounded. A gas detection and monitoring unit mounted in the case includes gas, pressure, and temperature and humidity sensors in communication with an ambient atmosphere outside the case, a data processor operatively connected to the sensors, data storage, an information display viewable through the case, and a calibration unit for calibrating the gas sensor to a predetermined gas concentration measured by the gas sensor.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 17, 2017
    Applicant: Acrulog Pty. Ltd.
    Inventor: Brian Worth
  • Publication number: 20170234846
    Abstract: In one aspect of the present disclosure, there is provided a sensor device for sensing a fluorine-based gas, the device comprising: a substrate; and a sensing layer on the substrate, wherein the sensing layer includes hydrogenated titanium dioxide nano-particles, wherein when the sensing layer reacts with the fluorine-based gas, the sending layer has a color change.
    Type: Application
    Filed: September 26, 2016
    Publication date: August 17, 2017
    Applicant: Industry-Academic Cooperation Foundation of Ajou University
    Inventors: Hyungtak SEO, Go Woon SHIM, Sang Yeon LEE
  • Publication number: 20170234847
    Abstract: A particulate lanthanide-doped material comprising an inorganic host phosphor and a lanthanide ion dopant. With the lanthanide-doped material being in an oxidized state, photoluminescence is suppressed. Photoluminescence of the material can be activated by the presence of a reducing substance that reduces the lanthanide-doped material in a redox interaction. The lanthanide-doped material can be used for biodetection (e.g. detecting the presence of microorganisms in a sample). This could have numerous applications, such as detecting the presence of contaminating microorganisms in a sample (e.g. in a food or cosmetic product).
    Type: Application
    Filed: February 13, 2017
    Publication date: August 17, 2017
    Inventors: Vivian Hsiao, Vincent Mar
  • Publication number: 20170234848
    Abstract: A water quality sensor includes a housing having two hollow protruding portions, and a sensing module including a circuit board mounted inside the housing and having two positioning plates respectively positioned in the two hollow protruding portions, two identical connectors respectively mounted on the two positioning plates of the circuit board in reversed directions with a phase difference of 180 degrees therebetween, and a light emitter and a light receiver respectively mounted in the connectors to face toward each other for water quality detection. Thus, the invention allows the implementation of automated assembly to replace manual assembly, reducing the risk of human error, saving much labor and production costs, improving product quality and increasing product yield.
    Type: Application
    Filed: February 13, 2017
    Publication date: August 17, 2017
    Inventors: Chih-Teng CHENG, Fu-Min LIANG, Chin-Feng CHEN
  • Publication number: 20170234849
    Abstract: Improved methods of detecting thermal exposure are provided herein. The provided methods utilize initially dormant luminescent probes incorporated into a matrix to form a composite. When exposed to heat over a period of time, the luminescent probes are “activated” through a molecular transformation initiated by thermal energy. The activated probes exhibit a luminescent profile based on the extent of thermal exposure, thereby providing an indicator of the thermal exposure experienced by the matrix. When the composite is used to produce a structural component of a vehicle (e.g., an aircraft), the methods provide a convenient, large-area indicator of thermal damage experienced by the structural component.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Brian D. Flinn, Alex Kwan-yue Jen, Sei-Hum Jang, Tucker Howie, Zhengwei Shi
  • Publication number: 20170234850
    Abstract: Disclosed herein are methods and compositions for detection of target small molecules in a mixed sample by performing a competition assay between the target and a surrogate and subsequently detecting the complex types in a nanopore device. Disclosed herein are competition assays for detection of small molecules using a nanopore. Target molecules of a sufficient size (>20 kDa) when passed through a solid-state nanopore cause a change in the current impedance, translocation time, or other measurable parameter. In the event the target molecule is not sufficiently big, and thus does not cause a noticeable change, an additional molecule/reagent can be used to aid in detection. This detection reagent would bind to the small molecule or to the “capture ligand-molecule complex” (e.g. peptide detection is aided by a monoclonal antibody (mAb) that recognizes a peptide/aptamer complex).
    Type: Application
    Filed: March 11, 2016
    Publication date: August 17, 2017
    Inventor: Trevor J. MORIN
  • Publication number: 20170234851
    Abstract: The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are accommodated in a passage bounded by a first step, but at least some of the particles arc unable to pass through a narrower passage bounded by a second step, resulting in segregation of the particles. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate fetal-like cells from a maternal blood sample such as maternal arterial blood.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Inventors: George Hvichia, David Counts, Gary Evans
  • Publication number: 20170234852
    Abstract: The present invention relates to a disease-specific metabolite profile, and particularly to a biomarker composition obtained by screening from urine-specific metabolite profiles of coronary heart disease subjects. The present invention also relates to a use of the biomarker compositions in risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease, and to a method for risk assessment, diagnosis, early diagnosis, or pathological staging of coronary heart disease. The biomarker composition as provided by the present invention can be used for early diagnosis of coronary heart disease and has high sensitivity, good specificity and good application prospects.
    Type: Application
    Filed: September 30, 2014
    Publication date: August 17, 2017
    Applicants: BGI SHENZHEN CO., LIMITED, BGI SHENZHEN
    Inventors: Qiang Feng, Zhipeng Liu, Nan Meng, Jun Wang
  • Publication number: 20170234853
    Abstract: The present invention relates to a method for dynamically determining the structural profile of a fibrin clot, reflecting the stability thereof in a biological sample of a patient. The method preferably includes a step that makes it possible to predict the risk of bleeding, thrombosis or rethrombosis and to select the anticoagulant that is best suited to the clinical situation of a patient.
    Type: Application
    Filed: July 24, 2015
    Publication date: August 17, 2017
    Inventors: Geneviève CONTANT, Benoît POLACK, François CATON, Carhel DASSI
  • Publication number: 20170234854
    Abstract: Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
    Type: Application
    Filed: December 19, 2016
    Publication date: August 17, 2017
    Inventors: AUSTIN L. GURNEY, AARON KEN SATO, FUMIKO TAKADA AXELROD, TIMOTHY CHARLES HOEY, SANJEEV H. SATYAL, SATYAJIT SUJIT KUMAR MITRA
  • Publication number: 20170234855
    Abstract: A high throughput, micro-screening process for the identification of fungal extracts that contain secondary metabolites with bioactivity is disclosed.
    Type: Application
    Filed: January 11, 2017
    Publication date: August 17, 2017
    Applicant: University of Findlay
    Inventor: Michael Edelbrock
  • Publication number: 20170234856
    Abstract: Dynamic expression behavior of recombinant living cells is used and detects translocation in an integral manner, preferably using a cell-inherent defense system, preferably gene sequences, ai-mi, in recombinant cells in a test kit for performing the detection method code for transporter proteins, Ai, with fluorescent marker proteins, Mi, as fusion constructs, Ai-Mi. The cell-inherent defense system is activated under the influence of foreign substance. Transporter proteins, Ai, that transport the foreign substance out of the living cells are expressed in an increased manner. Together with the transporter proteins, Ai, the marker proteins, Mi, are also expressed in an increased manner, which is optically detected and enables corresponding conclusions about the foreign substance.
    Type: Application
    Filed: July 10, 2015
    Publication date: August 17, 2017
    Inventor: Ulf-Georg Bickmeyer
  • Publication number: 20170234857
    Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 localization patterns following induced sperm capacitation, identifying the percentage of various patterns, particularly the ratio of [(AA+APM)/total number of GM1 localization patterns] and determining if the percentage of certain GM1 localization patterns in response to induced capacitation is altered. Based on the change in the percentage of localization patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 17, 2017
    Inventors: Alexander J. Travis, Cristina Cardona, Melissa A. Moody, Alana J. Simpson, G. Charles Ostermeier
  • Publication number: 20170234858
    Abstract: A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.
    Type: Application
    Filed: January 18, 2016
    Publication date: August 17, 2017
    Inventors: Michal Depa, Sidhant Jena, Gaurav Rohatgi, Aron O. Zingman
  • Publication number: 20170234859
    Abstract: The present invention provides small molecule compounds that can form covalent adducts with specific sequences of RNA, such as the hairpin loop r(CUG)exp sequence which is a cause of myotonic dystrophy type 1 (DM1), or the r(CGG)exp sequence which is a cause of fragile X-associated tremor/ataxia syndrome (FXTAS); to methods of making the small molecule compounds; and to methods of using the small molecular compounds in the treatment of DM1 or of FXTAS in patients afflicted therewith. The invention further provides a method for identifying an RNA target of a small molecule drug in vivo, using a small molecule drug conjugated to an RNA-reactive crosslinker group and a reporter group, contacting a cell or nucleic acid extract with the small molecule drug conjugate, then separating RNA targets crosslinked to the small molecule drug conjugate by interaction of the affinity group with a complementary affinity group.
    Type: Application
    Filed: February 8, 2017
    Publication date: August 17, 2017
    Inventors: Matthew D. Disney, Lirui Guan, Wang-Yong Yang
  • Publication number: 20170234860
    Abstract: Methods of quantifying the efficiency of a drug molecule for its targeted receptor, using a differential binding force to quantify the efficiency of a drug molecule to its targeted receptor.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 17, 2017
    Inventors: Shoujun XU, Qiongzheng HU, Yuhong WANG, Te-Wei TSAI
  • Publication number: 20170234861
    Abstract: Provided herein is a field-effect transistor based sensor for real-time detection of water contaminants and methods of use thereof.
    Type: Application
    Filed: August 3, 2015
    Publication date: August 17, 2017
    Inventors: Junhong Chen, Jingbo Chang
  • Publication number: 20170234862
    Abstract: The invention relates to methods for binding biologically active molecules to surfaces by coating the surface with a supported reagent in a first step and then covalently coupling said biologically active molecules to the supported reagent using a biorthogonal cycloaddition reaction. Fields of application of the invention include biochemical research, medical diagnostics and the pharmaceutical industry.
    Type: Application
    Filed: July 30, 2015
    Publication date: August 17, 2017
    Inventors: Vukic SOSKIC, Robert POPPE
  • Publication number: 20170234863
    Abstract: A biosensor includes a detection element having an analyte detecting portion which is monotonically increased in mass in response to detection of an analyte; a reference element having a reference measuring portion which exhibits no reactivity to the analyte; a mixer which mixes a detection signal responsive to mass variations in the analyte detecting portion from the detection element and a reference signal from the reference element; a measurement portion which calculates two candidate phase-change values of a positive value and a negative value, from a signal mixed by the mixer in accordance with a heterodyne system, and determines a phase-change value from the two candidate phase change value by judging whether the phase is positive or negative based on temporal changes in signal strength; and a detection amount calculation portion which calculates a detection amount of the analyte based on the phase change value determined by the measurement portion.
    Type: Application
    Filed: May 3, 2017
    Publication date: August 17, 2017
    Inventor: Hiroshi KATTA
  • Publication number: 20170234864
    Abstract: A condom for detection of STDs, including an interior condom surface having a control band and a test band, and an exterior condom surface that also has a control band and test band. Each test band allows binding and subsequent detection of STD antigens. A separate developing antibody produces a color change if bound to the antigen/antibody conjugate. The developing antibody may be present on the condom or applied separately after use.
    Type: Application
    Filed: February 13, 2017
    Publication date: August 17, 2017
    Inventors: Adam Arreola, Cameron R. Pye
  • Publication number: 20170234865
    Abstract: This application relates to assays, devices, and methods for conducting highly sensitive assays that employ two binding agents and are useful in detecting specific targets such as antigens. These devices and methods provide the ability to detect minute amounts of the specific target with reduced risk of false positive results.
    Type: Application
    Filed: February 15, 2017
    Publication date: August 17, 2017
    Inventor: Gerald F. SWISS
  • Publication number: 20170234866
    Abstract: The present invention provides a lateral flow multiplex assay strip, and lateral flow assay systems and kits comprising the assay strips of the invention and methods of using the assay strip and systems and kits to detect the levels of two or more target analytes that may be present in a liquid sample, wherein the two more target analytes are detectable at a single test area of the assay.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 17, 2017
    Inventors: Kimberly Hamad-Schifferli, Irene Bosch, Chun-Wan Yen, Helena de Puig, Justina O. Tam, Lee Gehrke
  • Publication number: 20170234867
    Abstract: The present invention relates to devices, kits, instruments and methods for quantitatively detecting multiple analytes in a sample. More specifically, the present invention relates to devices, kits, instruments and methods for quantitatively detecting multiple analytes with desired or targeted precision, and the uses thereof.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 17, 2017
    Applicant: Astute Medical, Inc.
    Inventors: Joseph ANDERBERG, Paul Harold MCPHERSON, Ravi VIJAYENDRAN
  • Publication number: 20170234868
    Abstract: The present disclosure provides a method of identifying a peptide antigen, including contacting an antibody-comprising composition to a peptide microarray having an array surface and a plurality of feature pairs disposed thereon. Each of the feature pairs includes a first feature of wild-type peptides having a defined sequence and a second feature of mutant peptides having the defined sequence with a single amino acid mutation. Each of the wild-type peptides and the mutant peptides has an array-coupled terminus coupled to the array surface and an opposing free terminus, and the position of the amino acid mutation in the mutant peptides is located closer to the array-coupled terminus of the mutant peptides than the free terminus. The method further includes detecting binding of an antibody in the antibody-comprising composition to at least one of the feature pairs on the peptide microarray, and identifying feature pairs exhibiting differential binding.
    Type: Application
    Filed: February 3, 2017
    Publication date: August 17, 2017
    Inventors: Ryan Bannen, Jigar Patel, Ken Lo
  • Publication number: 20170234869
    Abstract: Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-CarP) for the classification of individuals suffering from, or at risk of suffering from, arthritis.
    Type: Application
    Filed: April 4, 2017
    Publication date: August 17, 2017
    Applicant: Academisch Ziekenhuis Leiden H.O.D.N. LUMC
    Inventors: Leendert Adrianus Trouw, Anthony Cerami, Thomas Willem Huizinga, Jing Shi, Reinaldus Everardus Maria Toes, Petrus Antonius Veelen
  • Publication number: 20170234870
    Abstract: Resonance energy transfer (RET)- or protein-fragment complement assay (PCA)-based biosensors useful for assessing the activity of G-proteins are described. These biosensors are based on the competition between the Got subunit and a G?? interacting protein (?? IP) for the binding to the G?? dimer. These biosensors comprises (1) a ?? IP and (2) a G? or G? protein; a GPCR; or a plasma membrane targeting domain, fused to suitable RET or PCA tags. Methods using such biosensors for different applications, including the identification of agents that modulates G-protein activity or for the characterization of GPCR signaling/regulation, such as G-protein preferences and activation profiles of GPCRs, are also described.
    Type: Application
    Filed: October 14, 2015
    Publication date: August 17, 2017
    Inventors: Michel Bouvier, Christian Le Gouill, Mireille Hogue, Viktoriya Lukasheva
  • Publication number: 20170234871
    Abstract: The present invention relates to Mycobacterium tuberculosis (M tuberculosis) proteins and immunologically active fragments (peptides or mimotope peptides) thereof. In particular, the invention relates to a group of M. tuberculosis proteins and peptides thereof that are both highly antigenic and characteristic of clinical strains of M. tuberculosis. Accordingly, the further relates to the use of these M. tuberculosis proteins or peptides in diagnosing, treating or preventing M. tuberculosis complex infection.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 17, 2017
    Inventors: Massimo Amicosante, Ian Durrant, Scott Tasker
  • Publication number: 20170234872
    Abstract: The present invention relates to methods of screening biological samples for the presence of T. gondii. More particularly, the present invention relates to a sensitive and specific screening test for the presence of Toxoplasmosis in subjects by using or detecting the in vivo-induced T. gondii RAP domain binding protein antigen. The invention further relates to the use of the in vivo-induced antigen in the prevention or therapy of Toxoplasmosis.
    Type: Application
    Filed: October 1, 2015
    Publication date: August 17, 2017
    Inventors: Rahmah Binti Noordin, Atefeh Amerizadeh
  • Publication number: 20170234873
    Abstract: Antibiotics (Abx) are the world's most misused drugs. Antibiotics misuse occurs when the drug is administered in case of a non-bacterial infection (such as a viral infection) for which it is ineffective. Overall, it is estimated that 40-70% of the worldwide Abx courses are mis-prescribed. The financial and health consequences of Abx over-prescription include the direct cost of the drugs, as well as the indirect costs of their side effects, which are estimated at >$15 billion annually. Furthermore, over-prescription directly causes the emergence of Abx-resistant strains of bacteria, which are recognized as one of the major threats to public health today. This generates an immediate need for reliable diagnostics to assist physicians in correct Abx prescription, especially at the point-of-care (POC) where most Abx are prescribed. Accordingly, some aspects of the present invention provide methods using biomarkers for rapidly detecting the source of infection and administrating the appropriate treatment.
    Type: Application
    Filed: October 14, 2015
    Publication date: August 17, 2017
    Inventors: Kfir OVED, Eran EDEN
  • Publication number: 20170234874
    Abstract: The invention relates to detecting cell biomarker signatures and integrated cell biomarker-morphological profiles by detecting resonance-light scattering of functionalized nanoparticles.
    Type: Application
    Filed: October 5, 2016
    Publication date: August 17, 2017
    Inventors: Thomas H. Adams, Stephen Roman Fait, Eric Scott McCampbell, Michelle Brooke McCampbell, Edward Jablonski, Robert Earl Klem
  • Publication number: 20170234875
    Abstract: Methods and kits are provided for determining of immunoglobulin isotypes and subclasses in a subject. In general the subject is a human who is a transplant candidate recipient or recipient, has allergies, or has an autoimmune disease. The method involves analyzing a sample of a body fluid of a transplant candidate or recipient, allergy patient or autoimmune disease sufferer and correlating the relative amounts of each immunoglobulin isotype and subtype, such that the distribution of isotypes and subtypes is an indication of success of the transplant in the candidate and recipient or the prognosis of the autoimmune disease.
    Type: Application
    Filed: December 27, 2016
    Publication date: August 17, 2017
    Inventors: James C. Cicciarelli, Noriyuki Kasahara
  • Publication number: 20170234876
    Abstract: Rapid, point of care semi-quantitative tests for viral or bacterial antibody titer, and methods and kits for carrying out the same. The test article comprises a first elongated solid support with a sample application region and a detection region. The detection region comprises immobilized antigen that specifically binds a minimum immunoprotective level of antibody to at least one pathogen of interest. Depending upon the test results, the assay can rapidly indicate whether the animal has the presumptive minimally-protective level of antibody to the target pathogen, or needs to be re-vaccinated.
    Type: Application
    Filed: August 18, 2015
    Publication date: August 17, 2017
    Inventors: Rolan Davis, Michael Moore
  • Publication number: 20170234877
    Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.
    Type: Application
    Filed: April 20, 2017
    Publication date: August 17, 2017
    Inventors: David King, William F. Link, Renato del Rosario, Michael Leos
  • Publication number: 20170234878
    Abstract: Disclosed are compositions and methods for assessing the presence of tumor cells amongst normal cells.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 17, 2017
    Applicant: ISI Life Sciences, Inc.
    Inventors: Gerald F. Swiss, Robert M. Moriarty
  • Publication number: 20170234879
    Abstract: The present invention provides a novel, isolated anti-CXCR4 antibody for use in the diagnosis of cancer.
    Type: Application
    Filed: November 8, 2016
    Publication date: August 17, 2017
    Inventors: Christine KLINGUER-HAMOUR, Alexandra JOUHANNEAUD, Marie-Claire JANIN-BUSSAT
  • Publication number: 20170234880
    Abstract: The data provided herewith show that, biomarkers found within the cells of a tumor or cancer may also be present at adequate levels within the patient's urine to enable detection. Method of diagnosis, patient selection and treatment are provided, along with kits and devices.
    Type: Application
    Filed: August 13, 2015
    Publication date: August 17, 2017
    Applicant: Agency for Science, Technology and Research
    Inventor: Qi Zeng
  • Publication number: 20170234881
    Abstract: The present invention relates to methods for the diagnosis and the treatment of cancer, in particular breast cancer. In particular, the present invention relates to a method of diagnosing cancer in a subject comprising the steps of i) determining the expression level of 11?HSD1 and/or 11?HSD2 in a sample obtained from the subject, ii) comparing the expression level determined at step i) with its predetermined reference value and ii) concluding that the subject suffers from a cancer when the expression level of 11?HSD1 is lower than its predetermined reference value or when the expression level of 11?HSD2 is higher than its predetermined reference value.
    Type: Application
    Filed: September 7, 2015
    Publication date: August 17, 2017
    Inventors: Marc POIROT, Sandrine POIROT
  • Publication number: 20170234882
    Abstract: The present invention generally relates, in some embodiments, to methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy.
    Type: Application
    Filed: December 9, 2015
    Publication date: August 17, 2017
    Applicant: Quanterix Corporation
    Inventors: David Wilson, David C. Duffy, David Hanlon, David Okrongly
  • Publication number: 20170234883
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
    Type: Application
    Filed: January 25, 2017
    Publication date: August 17, 2017
    Applicant: Genentech, Inc.
    Inventors: Mark S. DENNIS, Bonnee RUBINFELD, Paul POLAKIS, Aya JAKOBOVITS
  • Publication number: 20170234884
    Abstract: The present invention provides a novel approach to cancer diagnosis and therapy of cancer by providing compositions and methods for the identification and specific targeting of the cancer stem cell populations present in a tumour to eradicate, or slow or prevent tumour (5) growth and spread, including the potential for tumour metastasis, by modulation of the Renin-Angiotensin System including, but not limited to, Renin Receptor, Angiotensin II Receptor (2) and a secreted form of the Renin Receptor.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 17, 2017
    Inventors: Ranui Francesca BAILLIE, Paul Frank DAVIS, Tinte ITINTEANG, Swee Thong TAN
  • Publication number: 20170234885
    Abstract: Methods for quantifying biospecimen sample integrity using oxidation. Embodiments include assessing ex vivo oxidation of a biospecimen sample by quantifying a difference in protein oxidation of the biospecimen sample in comparison to protein oxidation of a portion of the biospecimen sample intentionally incubated to cause oxidation to hit its maximum value. The difference in a level of oxidation in the biospecimen sample and the potion of the biospecimen sample is then inversely proportional to the degree of ex vivo oxidation.
    Type: Application
    Filed: March 27, 2017
    Publication date: August 17, 2017
    Inventors: Chad Borges, Joshua Jeffs
  • Publication number: 20170234886
    Abstract: Disclosed herein are methods and systems for detecting two different epitopes in the same sample using immunohistochemical methods using primary antibodies from the same host species and secondary antibodies immunoreactive with antibodies of the host species of the primary antibodies. Methods to denature and block the first primary antibody contacted with the sample are provided.
    Type: Application
    Filed: May 2, 2017
    Publication date: August 17, 2017
    Inventors: Jacquelyn Smith, Harry James Hnatyszyn, Erik Olson, Noah Theiss, Alton Yates, Eric Kaldjian, Bharathi Vennapusa
  • Publication number: 20170234887
    Abstract: The present invention relates to a method for detecting a spatial proximity of a first and a second epitope (11, 21) of a protein or of a first and a second protein (10, 20) of a protein complex (1) in a sample of a subject. The method comprises binding a first binding member (30) having a first oligonucleotide (31) conjugated thereto to the first epitope (11), binding a second binding member (40) having a second oligonucleotide (41) conjugated thereto to the second epitope (21), and determining whether a Fluorescence Resonance Energy Transfer (FRET) effect is present between a donor fluorophore (32) and an acceptor fluorophore (42), which are associated with the first oligonucleotide (31) and the second oligonucleotide (41), wherein the presence of the FRET effect indicates a spatial proximity of the first and the second oligonucleotide (31, 41) and, thus, the spatial proximity of the first and the second epitope (11, 21).
    Type: Application
    Filed: September 30, 2015
    Publication date: August 17, 2017
    Inventors: FREEK VAN HEMERT, REINHOLD WIMBERGER-FRIEDL, DIANNE ARNOLDINA MARGARETHA WILHELMINA VAN STRIJP
  • Publication number: 20170234888
    Abstract: The present invention provides a method for predicting whether a human patient 65 years of age or older is at increased risk for developing heart failure, comprising obtaining the results of an assay that measures levels of NT-proBNP and/or cardiac troponin T in a specimen from the patient wherein an increased NT-proBNP and/or cardiac troponin T level compared to levels in a control indicate an increased risk for developing heart failure.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 17, 2017
    Inventors: Christopher Defilippi, Stephen Seliger, James De Lemos, Robert H. Christenson
  • Publication number: 20170234889
    Abstract: A method of determining whether a subject has a vascular risk that can be reduced by blood pressure lowering therapy with antihypertensive drugs (e.g. Angiotensin converting enzyme inhibitor (ACE inhibitor), Angiotensin Receptor Blocker (ARB), Beta-Adrenoreceptor Blocker (Beta-blocker) and/or statins) by determining the level of hGH, and/or its isoforms in a blood sample of said subject and comparing the determined level of hGH, and/or its isoforms in said blood sample with a pre-determined threshold.
    Type: Application
    Filed: October 1, 2015
    Publication date: August 17, 2017
    Applicant: Sphingotec GmbH
    Inventors: Andreas BERGMANN, Olle MELANDER, Leong NG
  • Publication number: 20170234890
    Abstract: A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-? (A?) conformers, comprising the steps of: —fractionating a sample including various A? conformers; —immobilizing a biotinylated A? conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and —deriving the binding behavior of an aggregate quality control probe to the desired A? conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.
    Type: Application
    Filed: June 25, 2014
    Publication date: August 17, 2017
    Inventors: Dieter WILLBOLD, Julian GLUECK, Daniel FRENZEL, Luitgard NAGEL-STEGER, Oleksandr BRENER
  • Publication number: 20170234891
    Abstract: The present invention relates to novel fragments of beta-amyloid peptide and molecules binding thereto, as well as the use of said fragments and molecules in a method for prognosing/diagnosing and/or preventing/treating beta-amyloid aggregation related disorders.
    Type: Application
    Filed: March 30, 2015
    Publication date: August 17, 2017
    Inventors: Adrian W. SCHMID, Marc MONIATTE
  • Publication number: 20170234892
    Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 17, 2017
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Robert M. Umek, Pankaj Oberoi
  • Publication number: 20170234893
    Abstract: The present invention provides methods for analyzing a target compound from a biological sample. In one aspect, a method for analyzing a target compound in a biological sample can comprise delivering a biological sample through an affinity column, the affinity column having a binding ligand coupled to a stationary structural support, wherein the affinity column has a high density of the binding ligand per the stationary structural support and wherein the binding ligand has been preselected to cause weak affinity separation zonal retardation of the target compound from the biological sample forming a target compound fraction and a biological sample fraction and detecting the target compound by mass spectrometry.
    Type: Application
    Filed: September 19, 2016
    Publication date: August 17, 2017
    Inventors: Sten Ohlson, Anthony R. Torres
  • Publication number: 20170234894
    Abstract: Electrochemical impedance-based label-free and rapid biosensor for select bodily fluid biomolecule levels. Monoclonal antibodies to of biomolecule such as Cortisol were covalently attached to a 16-mercaptohexadecanoic acid functionalized gold working electrode using zero-length crosslinkers N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and 10 mM N-hydroxysulfosuccinimide. Cortisol was detected in phosphate buffered saline (simulated tear fluid) using a simple ferrocyanide reagent with a lower limit of detection of 18.73 pM and less than 10% relative standard deviation.
    Type: Application
    Filed: July 27, 2015
    Publication date: August 17, 2017
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jeffrey LaBelle, Tina Hakimi, Brittney Cardinell