Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

Abstract: A wearable apparatus selects at least two signal channels corresponding to an arterial signal, the channels associated with corresponding optical sensors of the wearable apparatus. Data is obtained from signal channels over a predetermined time. A function is applied to the data to transform the data to a frequency domain. Phase values are determined for frequency components of the data in the frequency domain. A phase difference value is determined between the phase values. A time shift value is determined between the data based on the phase difference value. A modified pulse transmit time is determined, based on the time shift value, representing a transit time for a pressure wavefront to travel between optical sensors. A pulse wave velocity is determined based on the modified pulse transit time. A blood pressure value is calculated based on the pulse wave velocity. A message is provided based on the blood pressure value.

Abstract: The invention described provides a way to use video image to estimate the human artery blood pressure reducing or completely eliminating the need for human contact (non invasive). Since video images can be stored and transmitted, the estimation of the blood pressure can be performed locally, remotely and in real time or offline.

Abstract: This disclosure provides devices and methods for estimating blood pressure using intelligent oscillometric blood pressure measurement techniques, where some implementations of the devices include multiple biometric sensors and/or can obtain sensor data from a connected device. In some implementations, the devices automatically determine an identity of a user. In some implementations, the devices automatically provide instructions to users to take blood pressure measurements. In some implementations, the devices applied intelligent inflation techniques to improve user comfort and speed up measurements.

Abstract: A pulse photometry probe includes a holding member that includes a contact face which is to be in contact with living tissue of a patient, an emitter that is placed in the holding member, a detector that is placed in the holding member and detects light emitted from the emitter, and, a spacer that is disposed between the contact face and the emitter and has an opening, wherein an air layer defined by the opening is disposed between an emitting face of the emitter and the contact face.

Abstract: A nerve impulse signal stimulation device and a method for fabricating the same are provided. The nerve impulse signal stimulation device includes: a substrate having a first surface and a second surface opposite to the first surface; a first metal layer formed on the first surface of the substrate; a second metal layer formed on the first metal layer; a plurality of openings exposing a portion of the first surface of the substrate, a portion of the first metal layer and a portion of the second metal layer; and a ferromagnetic material attached to the second surface of the substrate. The openings cause the nerve impulse signal stimulation device to obtain a parallel circuit structure, thereby increasing the current load and the magnetic field intensity, reducing the size of the device, and ensuring the safety of operations.

Abstract: An implantable electrode array is provided, the electrode array comprising a substrate, the substrate having a front side and a back side, and a first number of first electrodes. The first electrodes are formed as contact pads, and are arranged on the front side. The substrate comprises a second number of prefabricated holes at predetermined positions, the holes extending from the front side through the substrate towards the back side, and being arranged such the holes may be penetrated by elongated electrodes placed at the predetermined positions.

Abstract: A method of determining atrial fibrillation includes determining if a patient's pulse beats form an irregular pattern. If so, presence of an irregular pulse is indicated to a patient and, an electrocardiogram is obtained for determining atrial fibrillation. Initially, a pulse is detected at regular time intervals from a first appendage when motionless, using a pulse detector and pulse rhythms from a succession of time intervals, each corresponding to a respective interval of time between successive pulse beats of a sequence of the pulse beats. Then, a second appendage makes contact with an electrically conductive unit, and electrocardiogram signals are detected simultaneously with pulse rhythms while the first appendage is motionless and both appendages are relaxed. The signals are then analyzed to determine whether, in combination, they are indicative of atrial fibrillation.

Abstract: A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.

Abstract: An evoked potential measuring apparatus includes: an evoked potential acquiring section which is configured to acquire a plurality of evoked potential waveforms from a subject in response to stimulation; an average processing section which is configured to arithmetically average the plurality of evoked potential waveforms to acquire an average waveform; a first statistical value calculator which, each time a waveform set including an N (N is 2 or more) number of evoked potential waveforms is acquired, is configured to calculate a first statistical value of the waveform set; and an updation processing section which is configured to update the average waveform to eliminate a waveform set in which the first statistical value exceeds a first threshold, from the arithmetic average.

Abstract: A method for detection of an evoked response signal in noise including: generating a plurality of stimuli; receiving a noisy signal related to an evoked response to the plurality of stimuli; divide the noisy signal into a plurality of responses to the plurality of stimuli; estimate a statistic matrix for the plurality of responses; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; apply weights to the plurality of responses to construct a final response; and output the final response. An apparatus having an input device configured to receive data related to a plurality of stimuli; and a processor configured to: receive a noisy signal and divide the noisy signal into a plurality of responses; estimate a statistic matrix; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; and apply weights to the plurality of responses to construct a final response.

Abstract: According to an aspect of the present inventive concept there is provided a method for determining a nociceptive withdrawal reflex threshold of a person, the method comprising: applying a plurality of stimulations to a person with different stimulation intensity levels in accordance with a stimulation intensity algorithm, wherein the plurality of stimulations comprises at least one stimulation having an intensity level provoking a spinal cord withdrawal reflex in the person, recording electromyographic data representative of muscle activity of the person in response to each stimulation of the plurality of stimulations, and processing the stimulation intensity levels and the electromyographic data according to a threshold calculation algorithm to calculate a measure of the nociceptive withdrawal reflex threshold of the person. There is also provided a corresponding system.

Abstract: The present application provides a left and right brain recognition method and device, and relates to the field of wearable devices. The method comprises: in response to that a user listens to an audio content meeting a predetermined condition, acquiring first brain electrical information of a first hemisphere of the user; and recognizing that the first hemisphere is a left brain or a right brain according to the first brain electrical information and reference information. The method and the device provide a left and right brain recognition method, facilitate a device that the user wears to perform automatic setting according to a recognition result, and enhance user experience.

Abstract: A magnetic resonance (MR) apparatus, the MR apparatus including a tissue pressing surface having one or more MR coil elements, the pressing surface being configured and sized to selectively indent a portion of an exterior tissue of a subject when a physical force is applied to the indenting substrate thereby reducing a distance between the one or more MR coil elements and a structure of interest located inside the subject.

Abstract: Methods, systems, and devices are provided for guiding surgical instruments using radio frequency (RF) technology. In general, the methods, systems, and devices can allow a trajectory, e.g., an angular approach, of a surgical instrument relative to a patient to be identified during use of the instrument in a surgical procedure being performed on the patient. The trajectory can be identified using a plurality of RF modules. The methods, systems, and devices can allow the trajectory to be compared to a predetermined trajectory so as to identify whether the trajectory matches the predetermined trajectory. A result of the matching can be communicated to a user of the instrument. Based on the result, the user can maintain the trajectory, e.g., if the trajectory matches the predetermined trajectory, or can adjust the trajectory to closer align the trajectory with the predetermined trajectory, e.g., if the trajectory does not match the predetermined trajectory.

Abstract: The present invention provides a MEMS sensor guidance system mounted on a surgical instrument and uses the MEMS sensor to determine Inertial Measurement Units to track rotation and acceleration in all three spatial directions. Further the invention provides a method of surgery in which a reference axis, a loci, and a depth are defined and the instrument including the sensor cluster of the invention is placed in relation to the y-axis and x-axis and following the working end is aligned and the orientation and depth data display is observed to aid in maintaining the desired instrument.

Abstract: A method and system for monitoring impairment indicators. The method comprises, during a first time window, measuring a first movement signal related to movement of a person with a movement sensor associated with the person, and measuring a first environmental signal with an environmental sensor. The method further comprises electronically storing at least one numerical descriptor derived from the first movement signal and the first environmental signal as reference data for the person. The method further includes, during a second time window, measuring a second movement signal related to movement of the person with the movement sensor and measuring a second environmental signal with the environmental sensor; and comparing at least one numerical descriptor derived from the second movement signal and the second environmental signal to the reference data to identify an impairment indicator.

Abstract: A method and system for monitoring impairment indicators. The method includes, during a first time window, measuring a first movement signal related to movement of the person with a movement sensor associated with the person, and measuring a first biological signal of the person with a biological sensor attached to the person. The method further includes electronically storing at least one numerical descriptor derived from the first movement signal and at least one numerical descriptor derived from the first biological signal as reference data for the person. The method includes during a second time window, measuring a second signal related to movement of the person with the movement sensor, and measuring a second biological signal of the person with the biological sensor.

Abstract: An extended wavelength defined as a length of a signal waveform corresponding to a locus traced by a detected signal of an inertial sensor in a time domain per unit time is calculated, and an activity state of an observed person observed by the inertial sensor is determined based on the extended wavelength.

Abstract: A method for monitoring impairment indicators, the method includes measuring, with a movement sensor attached to the person, a first signal related to movement of a person during a first time window and electronically storing the at least one numerical descriptor derived from the first signal as reference data for the person. The method further includes measuring, with the movement sensor attached to the person, a second signal related to movement of the person during a second time window and comparing at least one numerical descriptor derived from the second signal to the reference data as a factor to identify an impairment indicator. The present disclosure also includes a device for monitoring impairment indicators.

Abstract: The invention relates to a method for measuring the human heartbeat rate, comprising the steps of: 1) obtaining a video of the measured subject; 2) parsing the video into a series of image frames; 3) arranging the multiple generated image frames in sequential order; 4) detecting the position of the region of the face in each image; 5) obtaining the facial fluctuation frequency of the measured object according to the change of the position of the face region in the image frame system.

Abstract: An over-the-ear hearing assessment device and a method for evaluating the performance of over-the-ear hearing devices are described. An exemplary over-the-ear hearing assessment device includes an ear cup defining an interior volume and positionable at least partially over the ear of a user. The ear cup includes a shell, a cushion, and an acoustic port extending from an exterior to the interior volume of the ear cup. The acoustic port is sealably engagable with a microphone.

Abstract: A sweat sensor device (200) with analytical assurance includes at least one sensor (220) for detecting a first analyte, and at least one calibration medium (270) containing at least the first analyte. When the first analyte in the at least one calibration medium (270) comes into contact with the at least one sensor (220), the calibration medium (270) provides a calibration of the at least one sensor (220). A sweat sensor device (200) may further include a carrier (240) having at least one aperture (220a) and a reservoir (254) for storing the at least one calibration medium (270). The at least one aperture (220a) provides fluidic access to the at least one sensor (220) from the reservoir (254).

Abstract: The claimed invention relates to mobile computing monitoring of health statistics using chemically synthesized conjugate markers providing highly specific details of personal health states. Using portable computing and communications devices, commonly known as ‘smartphones’, personal health and wellness information is gathered from chemical markers and reported to the user. Chemical markers include chemicals which undergo a measurable color change when combined with body fluids such as saliva. Health information derived from chemical markers may be optically collected, locally reported and widely broadcast over a ‘cloud based’ internet data distribution system.

Abstract: Because reprocessing or refurbishing of physiological sensors reuses large portions of an existing sensor, the material costs for refurbishing sensors is significantly lower than the material costs for making an entirely new sensor. Typically, existing reprocessors replace only the adhesive portion of an adhesive physiological sensor and reuse the sensing components. However, re-using the sensing components can reduce the reliability of the refurbished sensor and/or reduce the number of sensors eligible for refurbishing due to out-of-specification sensor components. It is therefore desirable to provide a process for refurbishing physiological sensors that replaces the sensing components of the sensor. While sensing components are replaced, generally, sensor cable and/or patient monitor attachments are retained, resulting in cost savings over producing new sensors.

Abstract: A system for wirelessly monitoring the health of an infant comprising a sensing module removably disposed within a wearable article. At least a portion of the sensing module can be in contact with an infant's foot. The sensing module can include a processing unit configured to receive and process health readings received by the sensing module. A wireless transmitter can also be in communication with the processing unit. The wireless transmitter can be configured to transmit the processed health readings to a receiving station. The receiving station can indicate an alarm if the processed health readings indicate a health trend that falls outside of a particular threshold.

Abstract: Exemplary embodiments are directed to skin test reading devices that include a housing and a short wave infrared (SWIR) detector. The SWIR detector can include a lens configured to enable the SWIR detector to capture an image of a skin testing area of a patient. The SWIR detector can be configured to detect a wheal formed on the skin testing area of the patient. Exemplary embodiments are also directed to methods of reading a skin test and skin test reading systems.

Abstract: A system for determining the location of patients uses a patient-associated communicator which wirelessly communicates with a network of environmental reference communicators arranged at fixed or otherwise known locations. A camera can be used to monitor or detect pressure ulcers and relay the information to a host system. Other embodiments are also disclosed.

Abstract: Methods and systems for seamless adjustment of treatment are disclosed. A determination is made as to whether to intervene with a patient's treatment. Implanted device memory data is acquired over a pre-specified time period. Risk status is determined from the device memory data. Another external device memory data is acquired over a pre-specified time period. A determination is made as to whether to adjust treatment of the patient in response to the risk status, the data acquired from the implanted device memory and the external device memory data.

Abstract: The present invention describes an apparatus and method for determining the energy expenditure of a subject by indirect calorimetry where respiratory gases O2 and CO2 are captured in a tent mask coupled through a pneumotach flow meter to a vacuum inlet of a blower fan whose speed is controlled by a computer running a program that ensures that the bias flow being drawn through the mask always exceeds the subject's peak expiratory flow. VO2 and VCO2 and flow values are measured on a breath-by-breath basis and used in arriving at a bias flow adjustment voltage to be applied to the blower fan for adjusting its speed.

Abstract: An optical sensing system is presented for monitoring one or more parameters or conditions of an object. The optical sensing system comprises: an elongated light guide configured for placing in proximity of the object, the light guide defining a cavity for light propagation therethrough along at least one light propagation path, and having a light input port and at least one light output port; and a detector system for receiving light propagating from the at least one light output port, the detector system being configured and operable for monitoring a signal modulated by light interaction with the object and being indicative of the at least one parameter/condition of the object.

Abstract: A physical assessment parameter sensing device includes a layer attachable to a patient, a sensing unit operable to detect a physical assessment parameter of the patient, and an antenna connected to the circuit and operable to receive and transmit a radio frequency signal. The antenna is movably disposed within the sensing device. In certain examples, the sensing device includes an enclosure within which the antenna is movably received.

Abstract: A method involves supporting both a sensor which measures biological information and an insertion needle at a location proximally spaced from the distal end portion of a device body. The sensor includes a detector which detects a body fluid component of the patient used to measure the biological information, and a signal processor which is attached to the device body and which processes a signal including the biological information. The method also involves moving the sensor and the insertion needle in the distal direction so that the detector and a portion of the insertion needle protrude distally beyond the distal end portion of the device body, separating the insertion needle from the sensor by moving the insertion needle relative to the sensor toward a proximal direction, and electrically connecting the sensor and the signal processor by operation of the device body after the insertion needle is separated from the sensor.

Abstract: Embodiments relates to a method and apparatus for risk stratification, monitoring, detection and prediction of adverse events in bedridden people. The method and apparatus can be used to prevent heath related conditions in people.

Abstract: To provide a biological-information analyzing device, a biological-information analyzing system, and a biological-information analyzing method that can appropriately measure biological information even in a user having an athlete's heart. A biological-information analyzing device includes a biological-information detecting section configured to detect biological information of a user, a user determining section configured to determine an exercise capability of the user, an information setting section configured to set, when it is determined that the exercise capability of the user satisfies a predetermined condition, analysis information corresponding to the exercise capability of the user, and an analyzing section configured to analyze the biological information on the basis of the set analysis information.

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

Abstract: A bio-sensing device (and method) calibrates a time period used to make bio-physical measurements. The device initiates a light source sense phase followed by a first ambient sense phase and a second ambient sense phase. In the light source sense phase, the device is configured to receive a digital value indicative of current through a photodetector while the light source circuit is enabled and in each of the first and second ambient sense phases, the device is configured to receive digital values while the light source circuit is disabled. The device iteratively varies the time period between the phases until the digital value received during the first ambient sense phase is within a threshold of the digital value received during the second ambient sense phase. It then applies the same time separation between the light source sense phase and the ambient phase thereby equalizing the magnitude of the ambient light in the two phases.

Abstract: [Problem] It is intended to quantitatively evaluate deterioration in brain function associated with a disease such as dementia, with a high degree of accuracy by a simplified method using signals acquired from a few sensors arranged on the scalp.

Abstract: Detecting chronotropic incompetence includes determining, using a processor, a baseline cardiac health measure for a user based upon an estimate of activity level for the user, validating, using the processor, the estimate of activity level for the user with a validation factor determined from sensor data and determining, using the processor, a cardiac health measure for the user from the sensor data. A signal indicating chronotropic incompetence for the user can be provided by the processor based upon a comparison of the cardiac health measure for the user with the baseline cardiac health measure.

Abstract: Methods and systems for monitoring workplace safety and evaluating risks is provided, the method comprising receiving signals from at least one wearable device, identifying portions of the signals corresponding to physical activities, excerpting the portions of the signals corresponding to the physical activities, and calculating risk metrics based on measurements extracted from the excerpted portions of the signals, the risk metric indicative of high risk lifting activities.

Abstract: Methods and systems for performing T1 mapping. T1 samples are obtained from an acquisition including one or more inversion groupings. The acquisition may be designed to result in incomplete tissue magnetization recovery between inversion groupings. The acquisition may be designed for the use of non-uniform, non-180° preparatory pulses. The method may also include the combined use of data from different inversion groupings. A model is used in which fit parameters are variable dependent on the inversion grouping.

Abstract: Monitoring health status of a user may be performed by an apparatus that includes a sensor adapted to generate sensor data, a memory adapted to store a plurality of baseline biological markers for a user, wherein the plurality of baseline biological markers include respiratory rhythm, and a processor coupled to the memory and the sensor. The processor is adapted to, in response to detecting that the user is performing physical activity, determine a biological marker from the sensor data. The processor is adapted to compare the biological marker with the baseline biological marker. The processor is further adapted to, in response to detecting a change in the biological marker, provide a notification indicating a change in health status.

Abstract: A monitoring system is disclosed for in vivo monitoring of preselected physiological parameters associated with acute and/or chronic tissue compromise or failure in one or multiple tissue/organ sites in real time. In one method, a body portion of a surgical stapling device is positioned adjacent a first tissue section, an anvil assembly adapted to engage the body portion is positioned adjacent a second tissue section, and a monitoring device is positioned adjacent the first and/or second tissue sections. The monitoring device includes a sensor adapted to measure a preselected physiological parameter and a transmitter for transmitting signal to an extracorporeal receiving unit. The surgical stapling device is fired to mechanically secure the first and second tissue sections with at least one staple and the preselected physiological parameter is monitored via the information transmitted from the monitoring device to the receiving unit.

Abstract: A super-resolution digital tomosynthesis system for imaging an object including a source configured to emit penetrating particles toward an object; a detector configured to acquire a series of projection images of the object in response to the penetrating particles from the source; positioning apparatus configured to position the source and the detector; and an imaging system coupled to the source, the detector, and the positioning apparatus. The imaging system is configured to control the positioning apparatus to position the source in relation to the detector along a scan path and to change a distance between the source and the detector, control the source and the detector to acquire the series of projection images along the scan path with the distance change between the source and detector, and construct a tomographic volume exhibiting super-resolution from data representing the acquired series of projection images.

Abstract: Aspects of the present disclosure disclose a system and method for delivering for administering radiation to a patient. The method may include associating the patient with one of a plurality of coded dosage zones wherein each of the plurality of coded dosage zones corresponds to one or more values of a physical characteristic. The method may further include correlating the one of the plurality of coded dosage zones to a dose of radiation and then applying the dose of radiation to the patient.

Abstract: Disclosed is an X-ray imaging device for radiographing an object including a generator configured to emit X-rays and a sensor unit configured to detect the X-rays using at least one sensor, a gantry having the generator and the sensor unit facing with the object therebetween, and a sensor moving part provided in the sensor unit and configured to move the sensor while the generator and the sensor while the gantry rotates about a rotating axis.

Abstract: Disclosed is an X-ray imaging device, which is capable of providing a tomographic image of an image layer disposed between an axis of rotation and an X-ray source. The imaging device according to the present invention includes a radiography unit having an X-ray source and an X-ray sensor disposed to face each other with a rotating axis therebetween, wherein the X-ray sensor configured to obtain X-ray transmission images, a driver configured to rotate the X-ray source and the X-ray sensor about the rotating axis, and an image processor configured to provide a two-dimensional tomographic image of an image layer disposed between the rotating axis and the X-ray source, by shifting and overlapping the X-ray transmission images after reversing left and right at least some of the X-ray transmission images.

Abstract: A method of designing an x-ray emitter panel 100 including the step of determining a pitch scale, r, to be used in placing x-ray emitter elements 110 on the panel 100, thereby arriving at a specific design of x-ray emitter panel 100 suitable for a specific use.

Abstract: The present invention relates to a device for displaying image information, the device comprising: a detection unit (10), which is configured to identify a plurality of admissible display orientations of multiple data sets; a restriction unit (20), which is configured to restrict the plurality of admissible display orientations of at least one of the multiple data sets to a set of admissible display orientations in common for all the multiple data sets; and/or to restrict a plurality of admissible scrolling directions of at least one of the multiple data sets to a set of admissible scrolling directions that are normal to the restricted admissible display orientations; and a display unit (30), which is configured to display the multiple data sets using the set of the restricted display orientations and/or the set of restricted scrolling directions.