Patents Issued in September 21, 2017
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Publication number: 20170266321Abstract: A water-soluble compound of the formula (I): wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.Type: ApplicationFiled: February 28, 2017Publication date: September 21, 2017Applicant: University of BristolInventors: Chenfeng KE, Anthony P. Davis
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Publication number: 20170266322Abstract: The present invention provides non-human animal models of neuronal injury and/or cognitive dysfunction and methods of making and using such animal models. The animal models of the invention are particularly suited to assessing neurodegeneration in selected regions of interest in the CNS, and thus especially useful for testing the therapeutic efficacy of agents targeting neurodegeneration associated with aging, neurodegenerative diseases, autoimmunity and trauma (e.g., ischemia).Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Inventors: Katerina Akassoglou, Jae Kyu Ryu
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Publication number: 20170266323Abstract: Embodiments of the present disclosure provide for compositions including organic, water-soluble NIR-II fluorescent agent that emit radiation at about 1.0 to 1.7 ?m, methods of making the composition, methods of imaging a disease and related biological events, methods of imaging, monitoring and/or assessing a disease and related biological events, and the like.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventors: Zhimin Tao, Guosong Hong, Yingping Zou, Chihiro Fukunaga, Hongjie Dai, Shuo Diao, Alex Antaris
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Publication number: 20170266324Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Inventors: Patrick Campbell, Amarpreet S. Sawhney
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Publication number: 20170266325Abstract: Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR contrast agents. Examples include, but are not limited to, multivalent linear polymers, branched polymers, or hyperbranched polymers, such as dendrimers, and combinations thereof. The dendrimer is functionalized with one or more high Z-elements, such as iodine. The high Z-elements can be covalently or non-covalently bound to the dendrimer. The dendrimers are confined in order to enhance CT contrast. In some embodiments, the moiety is confined by encapsulating the dendrimers in a material to form particles, such as nanoparticles. In other embodiments, the dendrimer is confined by conjugating the moiety to a material, such as a polymer, which forms a gel upon contact with bodily fluids.Type: ApplicationFiled: May 13, 2015Publication date: September 21, 2017Applicant: Yale UniversityInventors: Tarek Fahmy, Albert Sinusas, Dongin Kim
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Publication number: 20170266326Abstract: The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.Type: ApplicationFiled: November 30, 2016Publication date: September 21, 2017Applicant: Lantheus Medical Imaging, Inc.Inventors: Heike S. Radeke, Richard R. Cesati, Ajay Purohit, Thomas D. Harris, Simon P. Robinson, Ming Yu, David S. Casebier, Carol Hui Hu, Matthias Broekema, David C. Onthank
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Publication number: 20170266327Abstract: Disclosed are chemical entities of formula (I) wherein R1, R2 and n are defined herein, and methods of use thereof. These chemical entities are radiative emitters and are useful, e.g., as therapeutic agents for the treatment of, or as diagnostic (e.g., imaging) agents for cancers, e.g., cancers in which PARP1 is overexpressed.Type: ApplicationFiled: August 27, 2015Publication date: September 21, 2017Inventors: Thomas Reiner, Jason S. Lewis, Wolfgang Weber, Beatriz Salinas Rodriguez, Brandon Carney, Giuseppe Carlucci
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Publication number: 20170266328Abstract: The present disclosure, among other things, provides new technologies for preparation of medical isotope labeled metal(loid) chalcogen nanoparticles for use in medical imaging and/or therapeutic applications. Provided technologies show a number of advantages as compared with previously available options for preparing and utilizing medical isotopes, including, for example, they utilize metal(loid) chalcogen nanoparticles that serve as universal binders (e.g., via covalent or non-covalent (e.g., chelate) bonds) for medical isotopes to provide medical isotope labeled metal(loid) chalcogen nanoparticles. Surprisingly, the same metal(loid) chalcogen nanoparticles may be used to bind (e.g., covalent or non-covalent e.g., chelation) bonding) a wide variety of different useful medical isotopes without the use of traditional chelating agents.Type: ApplicationFiled: July 28, 2015Publication date: September 21, 2017Applicant: Memorial Sloan Kettering Cance CenterInventors: Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Jan Grimm, Moritz F. Kircher
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Publication number: 20170266329Abstract: A remote control having an ultraviolet light emitting device for disinfecting the outer surfaces of the remote control is disclosed. In particular, the remote control may include an ultraviolet transmissive housing and internal ultraviolet emitting light emitting diodes. The ultraviolet transmissive housing allows the light from the internally mounted ultraviolet emitters to pass through the remote control's housing and kill bacteria, viruses, and other micro-organisms on the outer surface of the remote control by employing methods to automate safe and effective operations of ultraviolet light.Type: ApplicationFiled: May 31, 2017Publication date: September 21, 2017Inventors: Phuc H. NGUYEN, Christopher William Bruhn
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Publication number: 20170266330Abstract: A method for a hand-held device comprising illuminating, with a first UV LED associated with the hand-held device, a surface of an object with UV light, acquiring with a visible-light image sensor on the hand-held device, a first image of the surface of the object while the surface of the object is illuminated by the first UV LED, performing with the processor in the hand-held device, a function upon the first image to determine a type of contaminant disposed upon the surface of the object, determining with the processor in the hand-held device, sanitation techniques to perform in response to the type of contaminant that is determined, and displaying with a touch-screen display on the hand-held device, the sanitation techniques to the user.Type: ApplicationFiled: June 6, 2017Publication date: September 21, 2017Inventors: Yitao LIAO, Robert WALKER, Doug COLLINS, Sheung LI
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Publication number: 20170266331Abstract: The present invention disclosed a super dry fog generator comprising a liquid-storage device, an atomization device, an air-blower and a dry separation device with an opening on the top; wherein said dry separation device is above said liquid-storage device and connected with said liquid-storage device; said atomization device is located at the exterior of said liquid-storage device; the two ends of said atomization device are connected with said air-blower and the interior of said dry separation device, respectively; said atomization device is connected with said liquid-storage device, and the liquid entering into the interior of said atomization device is blown into the interior of said dry separation device by said air-blower. The disinfection liquid entering into the atomization device from the liquid-storage device is atomized into small atomized liquid particles by the atomization device, and then the small atomized liquid particles are driven into the dry separation device by said air-blower.Type: ApplicationFiled: June 28, 2016Publication date: September 21, 2017Inventors: Wanzhong LIU, Mingfang BIE, Chao ZHANG
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Publication number: 20170266332Abstract: Provided are a composition containing as active ingredients thereof Bacillus subtilis strain BN1001 (deposit number: FERM P-11132) and Bacillus subtilis var. natto, a wastewater treatment system provided with a biological treatment tank that biologically treats wastewater wherein the Bacillus subtilis strain BN1001 and Bacillus subtilis var. natto are contained in the biological treatment tank, a wastewater treating method that biologically treats wastewater comprising a step for adding the Bacillus subtilis strain BN1001 and Bacillus subtilis var. natto to the wastewater, a deodorization method comprising a step for contacting the Bacillus subtilis strain BN1001 and Bacillus subtilis var. natto with a malodorous source, a support having Bacillus subtilis and Bacillus subtilis var.Type: ApplicationFiled: August 25, 2015Publication date: September 21, 2017Inventor: Makoto Takaya
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Publication number: 20170266333Abstract: The present invention is directed to methods, compositions and articles comprising olfactory-active compositions. An article of the present invention comprises a structural component and an olfactory-active composition. The article may control the release, release rate or absorption of the olfactory-active composition. The article may be of various shapes and sizes. A method of use of an article comprises providing fragrance to an environment.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Applicant: ENVIROSCENT, INC.Inventors: Nicholas D. McKay, Jeffrey S. Sherwood, Jeffrey S. Hsieh, Pedro Antonio Rodriguez
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Publication number: 20170266334Abstract: The invention relates to a malodor counteractancy or counteracting (MOC) method that resorts to the use of specific malodor counteracting (MOC) mixtures of fragrance ingredients. More particularly, the invention relates to new MOC compositions capable of neutralizing or masking in an efficient manner malodors of a large variety of such as body or as malodors, kitchen malodors, toilet and bathroom malodors, and tobacco malodor. The novel MOC compositions of the invention contain at least one nitrite material in combination with another fragrance material and can be used in any finished consumer products such as air fresheners, kitchen or toilet/bathroom cleaning or freshening products, textile treatment products and products for application on the human skin or hair, or on animal fur, litter containers or cages.Type: ApplicationFiled: March 30, 2017Publication date: September 21, 2017Applicant: FIRMENICH SAInventors: Lyse TRANZEAT, Nicholas O'LEARY, Wessel-Jan KOS
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Publication number: 20170266335Abstract: An air treatment system includes a particulate filtration portion and a disinfecting portion that may be configured within a single enclosure, such as a conduit. The disinfecting portion may include a UV light source that emits UV light onto the interior surface of the conduit that has a photocatalyst surface. A disinfecting portion may include an X-ray portion, wherein an X-ray emitter is configured within the conduit. In one embodiment, the X-ray emitter is configured to emit X-rays along the conduit and toward a photocatalytic mesh that is also configured within the conduit. The particulate filtration portion may be configured upstream of the disinfection portion.Type: ApplicationFiled: November 25, 2015Publication date: September 21, 2017Inventors: Mohammed Al-Zeer, Abdulaziz Hamad Alzeer, Troy Smith
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Publication number: 20170266336Abstract: Superabsorbents comprising at least one compound of formula (I) or salt thereof, where R1 and R2 independently are H, organic or functional substituents, exhibit improved stability against discolouration.Type: ApplicationFiled: March 10, 2017Publication date: September 21, 2017Applicant: BASF SEInventors: Matthew Gande, Kristine Hartnagel, Katarzyna Dobrosielska-Oura, Felicitas Leonie Sperling
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Publication number: 20170266337Abstract: A biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-PDX) with a nucleophilic cross-linking agent is disclosed. The EL-PDX comprises m electrophilic groups; and the nucleophilic cross-linking agent comprises n nucleophilic groups, wherein the m electrophilic groups are capable of reacting with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein the EL-PDX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. Biocompatible medical products and kits comprising the cross-linked PDX-polymers are also disclosed.Type: ApplicationFiled: June 8, 2017Publication date: September 21, 2017Applicant: Bender Analytical Holding B.V.Inventors: Richard HOOGENBOOM, Johannes Caspar Mathias Elizabeth BENDER, Jan Cornelis Maria VAN HEST
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Publication number: 20170266338Abstract: A formulation of foam thermosensitive hydrogel includes a thermosensitive hydrogel including synthetic polymeric material. The thermosensitive hydrogel has properties of changing phase from liquid to solid in high temperature and changing phase from solid to liquid in low temperature. The foam thermosensitive hydrogel having a predetermined surface tension is formed after mixing the thermosensitive hydrogel with air. The foam thermosensitive hydrogel has properties of increased volume and being semisolid. After injecting the foam thermosensitive hydrogel into a human body, the foam thermosensitive hydrogel changes phase form liquid to solid after temperature rises above LCST. The foam thermosensitive hydrogel injected into the human body becomes a solid, physical barrier between an injured site and surrounding tissue, thereby preventing adhesion from forming in the human body. A method of manufacturing foam thermosensitive hydrogel is also provided.Type: ApplicationFiled: March 17, 2016Publication date: September 21, 2017Inventors: Chih-Hao Chen, Shih-Hsien Chen, Pang-Yun Chou, Shih-Hsuan Mao, Chien-Hung Liao
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Publication number: 20170266339Abstract: A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventor: Joseph A. Landolina
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Publication number: 20170266340Abstract: The present invention generally relates to the use of pre-formed bodies of Chemically Bonded Ceramics (CBCs) biomaterial for implantation purposes wherein the bodies are prepared ex vivo allowing process parameters to be optimized for desired long term properties of the resulting CBC biomaterial. More particularly, the pre-formed CBC material bodies of the present invention are sintered. The pre-formed body of CBC material is machined to the desired geometry and then implanted using a CBC cementation paste for fixation of the body to tissue. The invention also relates to a method of preparing pre-formed bodies of CBC biomaterial for implantation purposes, methods of preparing an implant thereof having desired geometry, and a method of implantation of the implant, as well as a kit for use in the method of implantation.Type: ApplicationFiled: May 12, 2015Publication date: September 21, 2017Applicant: DOXA AKTIEBOLAGInventors: Leif Hermansson, Jesper Lööf, Emil Abrahamsson
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Publication number: 20170266341Abstract: Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.Type: ApplicationFiled: June 7, 2017Publication date: September 21, 2017Inventors: Rebeccah Brown, Thomas J. Koob
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Publication number: 20170266342Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.Type: ApplicationFiled: March 15, 2016Publication date: September 21, 2017Inventors: Douglas G. EVANS, Scott M. GOLDMAN, Russell T. KRONEGOLD
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Publication number: 20170266343Abstract: Disclosed in certain embodiments is a composition comprising a biological material and transition metal atoms selected from the group consisting of Group IVB, Group VB, Group VIB of the Periodic Chart and a combination thereof, bound to a surface of the biological material.Type: ApplicationFiled: February 3, 2017Publication date: September 21, 2017Inventors: Randell Clevenger, Rong Dong, Jordan Katz
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Publication number: 20170266344Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.Type: ApplicationFiled: May 31, 2017Publication date: September 21, 2017Inventors: Xiaojie Yu, Nicolas J. Manesis, Jacob Pollock
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Publication number: 20170266345Abstract: The present invention relates to an ultra-thin film silk fibroin/collagen composite implant for tissue engineering and a manufacturing method therefor. The ultra-thin film silk fibroin/collagen silk fibroin/collagen composite implant according to the present invention has no cytotoxicity and can minimize the influence on cell growth, due to the combined use of a refined silk fibroin aqueous solution, collagen and various biomaterials, and thus can be widely used as an ultra-thin film implant for implanting.Type: ApplicationFiled: July 10, 2015Publication date: September 21, 2017Applicant: INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITYInventors: Gil Son KHANG, Eun Young KIM, Jae Won YANG, Jeong Eun SONG, Se Rom CHA
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Publication number: 20170266346Abstract: The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also relates to methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, such as but not limited to, orthopedic, dental, craniofacial and cardiovascular surgery.Type: ApplicationFiled: December 9, 2015Publication date: September 21, 2017Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: PRASHANT N. KUMTA, JINGYAO WU, OLEG VELIKOKHATNYI
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Publication number: 20170266347Abstract: Biomimetic grafts or implants coated with an osteogenic extracellular matrix and methods for production and use are described.Type: ApplicationFiled: May 13, 2015Publication date: September 21, 2017Applicant: The Board of Trustees of the University of IllinoisInventors: Sriram Ravindran, Praveen Gajendrareddy, Anne George
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Publication number: 20170266348Abstract: The present invention is directed to a fiber, preferably bone fiber, having a textured surface, which acts as an effective binding substrate for bone-forming cells and for the induction or promotion of new bone growth by bone-forming cells, which bind to the fiber. Methods of using the bone fibers to induce or promote new bone growth and bone material compositions comprising the bone fibers are also described. The invention further relates to a substrate cutter device and cutter, which are effective in producing substrate fibers, such as bone fibers.Type: ApplicationFiled: April 21, 2017Publication date: September 21, 2017Applicant: LifeNet HealthInventors: Barton D. GASKINS, Dennis L. PHELPS, Daniel B. OSBORNE, Louis E. FORD, Lloyd WOLFINBARGER, JR.
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Publication number: 20170266349Abstract: The invention provides a method of producing a connective tissue graft suitable for correcting a connective tissue defect, comprising determining the size and shape of a tissue defect, obtaining a fat tissue from a patient modelled to fit the size and shape of the tissue defect, contacting the fat tissue with one or more connective tissue specific growth or differentiation factors; and kits for such a method.Type: ApplicationFiled: July 30, 2015Publication date: September 21, 2017Inventors: Claudia Eder, Michael Ogon
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Publication number: 20170266350Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.Type: ApplicationFiled: September 9, 2015Publication date: September 21, 2017Applicant: University of WashingtonInventors: Shaoyi Jiang, Tao Bai, Harihara Subramanian Sundaram, Andrew William Sinclair, Jean-René Ella-Menye, Priyesh Jain
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Publication number: 20170266351Abstract: Embodiments relate to the design and use of a low profile ablation catheter with a liquid core for use in laser ablation removal of arterial plaque blockages to restore blood flow.Type: ApplicationFiled: June 6, 2017Publication date: September 21, 2017Applicant: RA MEDICAL SYSTEMS, INC.Inventors: James B. LAUDENSLAGER, Dean S. IRWIN, Cesar DIAZ
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Publication number: 20170266352Abstract: The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, at least in part, on the discovery that biomaterial coated with a cytokine eluting coating resulted in the shift of early stage macrophage polarization that were associated with positive long-term effects such as minimized capsule formation and improved tissue quality and composition as compared to uncoated biomaterials.Type: ApplicationFiled: March 15, 2017Publication date: September 21, 2017Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Bryan Nicklaus Brown, Daniel Jordi Hachim Diaz
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Publication number: 20170266353Abstract: Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.Type: ApplicationFiled: May 13, 2015Publication date: September 21, 2017Inventors: John L MURPHY, Christopher P RADANO, Jeffrey L. DALSIN, Justin T. KOEPSEL
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Publication number: 20170266354Abstract: The present invention provides a therapeutic device that comprises of mixture of cells secreting combination of therapeutic proteins, where cells producing therapeutic proteins are sealed in container which enables the exchange of nutrient and therapeutic proteins. The cells inside the therapeutic device produce and secrete certain amounts of therapeutic proteins. Cells are prepared by introducing genes encoding therapeutic proteins under the control of a constitutive or inducible promoter. The combination and concentration of therapeutic proteins is defined by the ratio of cells secreting different therapeutic proteins and/or by the gene expression ratio of the therapeutic proteins in the cells incorporated into the semi-permeable container. The therapeutic device can be used for treatments of various diseases and injuries for instance enhancement of wound healing and angiogenesis.Type: ApplicationFiled: September 4, 2014Publication date: September 21, 2017Inventors: Lucija KADUNC, Dusko LAINSCEK, Simon HORVAT, Roman JERALA, Iva HAFNER BRATKOVIC
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Publication number: 20170266355Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventor: Theodore Malinin
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Publication number: 20170266356Abstract: A dressing (2) and an apparatus (1) comprising the dressing, for cleansing the wounds (5) in which an irrigant fluid from a reservoir (12) connected to a conformable would dressing and would exudate from the dressing are moved by a device (18) (which may be a single pump or two pumps) for moving fluid through a flow Path (6, 7, 9, 10) which passes through the dressing with a means for providing simultaneous aspiration and irrigation of the wound, to provide a desired balance of fluid at a controlled nominal flow rate that removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting would healing over the wound bed.Type: ApplicationFiled: May 19, 2017Publication date: September 21, 2017Inventors: Patrick Lewis Blott, Edward Yerbury Hartwell, Julian Lee-Webb, Derek Nicolini
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Publication number: 20170266357Abstract: A system for the movement of fluids into and out of a surgical field is provided with a control module manipulated by a user; a valve controlled by the user via the control module, the valve controlling flow of a fluid; and a tube set having a proximal branch and a distal branch, wherein the proximal branch is opened and closed by the valve and at least a portion of the distal branch being flexible and a distal tip of the distal branch configured for manipulation within a surgical field. The valve is disposed at a distance to the surgical field and allows free access to tube by the user. Separate proximal branches for suction, irrigation, and insufflation are provided. One or more distal branches may be provided.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventors: Gary Douglas, Stephen M. Martone, David L. Regan, Nilendu Srivastava, Rachana Suchdev
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Publication number: 20170266358Abstract: A cardiac support system can be used to couple a conduit of a pump to a heart. The cardiac support system can include a sewing ring configured for attachment to the heart, a connector having a ring frame attached to the sewing ring, and having a channel and a frame recess extending radially outwardly from the channel and a spring component disposed partially within the frame recess. The cardiac support system can also include a pump housing having a radial protrusion having a distal surface and a proximal surface and a housing recess extending radially inwardly from the radial protrusion and configured to receive a portion of the spring component. The housing may also include a seal to form a fluid tight barrier between the housing and ring frame of the connector.Type: ApplicationFiled: March 17, 2017Publication date: September 21, 2017Inventor: Greg S. ABER
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Publication number: 20170266359Abstract: Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.Type: ApplicationFiled: January 3, 2017Publication date: September 21, 2017Inventors: Michael W. Dae, Timothy R. Machold
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Publication number: 20170266360Abstract: A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.Type: ApplicationFiled: June 6, 2017Publication date: September 21, 2017Applicant: NXSTAGE MEDICAL, INC.Inventors: Jeffrey H. BURBANK, Dennis M. TREU, Goetz FRIEDERICHS, Brian C. GREEN, Christopher S. MCDOWELL, James M. BRUGGER
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Publication number: 20170266361Abstract: The bifurcated peritoneal catheter serves as a peritoneal dialysis device for patients with kidney failure. The catheter includes a primary tube with two porous internal tubes extending therefrom at a small acute angle to one another. The two internal tubes provide a solution to the potential problem of blockage in a single catheter tube, greatly reducing the potential need for surgery to remove and replace such a single catheter tube. The bifurcated peritoneal catheter includes a subcutaneous cuff, and can include a second deep cuff in the abdominal wall. Either or both of the internal tubes can be straight, curved or coiled, with the curvatures and coils oriented in the same direction, toward one another, or away from one another.Type: ApplicationFiled: March 21, 2016Publication date: September 21, 2017Inventor: JAMAL S. AL WAKEEL
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Publication number: 20170266362Abstract: A blood treatment system comprising at least one first device and at least one second device, wherein the first device is a membrane filter for the removal of toxic mediators from blood and the second device is suitable for the removal of granulocytes and monocytes from blood. The first device has a first blood flow path a first blood flow path for conducting blood through and the second device has a second blood flow path. The first and second devices are serially connected in succession in such a way that the first blood flow path is in fluid communication with the second blood flow path. The membrane has an interior filter space in its housing and a semipermeable membrane arranged in the interior filter space, which membrane divides the interior filter space into a retentate chamber and permeate chamber. The housing has a blood inlet device and a blood outlet device that are in fluid communication with the retentate chamber, as well as a permeate outlet for diverting permeate from the permeate chamber.Type: ApplicationFiled: August 25, 2015Publication date: September 21, 2017Inventors: Bodo von Harten, Detlef Krieter, Horst-Dieter Lemke
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Publication number: 20170266363Abstract: A suction device includes an outer tube having an inlet at a first end and an inner suction tube located within the outer tube, the inner suction tube having an inlet at a first end corresponding to the first end of the outer tube. The inlet of the inner suction tube is offset by a distance from the inlet of the outer suction tube, such that the inlet of the inner suction tube is located within the outer suction tube.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Inventor: PRABHAT K. AHLUWALIA
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Publication number: 20170266364Abstract: A suction device includes an outer tube having an inlet at a first end and an inner suction tube located within the outer tube, the inner suction tube having an inlet at a first end corresponding to the first end of the outer tube. The inlet of the inner suction tube is offset by a distance from the inlet of the outer suction tube, such that the inlet of the inner suction tube is located within the outer suction tube.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Inventor: PRABHAT K. AHLUWALIA
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Publication number: 20170266365Abstract: This invention relates to a suction cup, a negative pressure transfer means a handling assembly comprising the suction cup and the negative pressure transfer means, a tray for securing the handling assemblies and a container grasping system comprising the tray and handling assemblies. The suction cup comprises channels that are secured by suction onto a perimeter of an aperture of a hole of the container and a protrusion positioned internally in relation to the channels that closes a hole of the container. The suction cup enables the container to be grasped and handled while closing its hole. The use of numerous suction cups in parallel enables numerous containers to be handled in parallel.Type: ApplicationFiled: March 8, 2017Publication date: September 21, 2017Inventor: ANTONIO MANCIONE
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Publication number: 20170266366Abstract: A package for a medical cannula with a hub, such as a pen needle, is disclosed. The package includes a cover for receiving a medical cannula and for engaging a hub of the medical cannula. The cover has open ends that are in communication through the cover. The packaging also includes a sterility barrier for the cover.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Applicant: Becton, Dickinson and CompanyInventors: Robert Banik, Peter Skutnik, Sean Sullivan
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Publication number: 20170266367Abstract: A medical infusion pump can be configured to sequentially inject solutions from multiple syringes. The medical infusion pump can be configured to automatically sequence the injection either by creating differential fluid pressures during injection or by employing a sequencer that creates differential forces on poppets which form seals between different input ports of the sequencer.Type: ApplicationFiled: June 5, 2017Publication date: September 21, 2017Inventors: Tyler G. Fish, Elisabeth M. Fish, Aaron Schellenberg
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Publication number: 20170266368Abstract: An assembly for an infusion device that delivers fluid to a user is disclosed. The assembly includes a reservoir and a piston actuator. The reservoir includes a body section having a fluid chamber, a fitting section extending from the body section, a housing lock structure to couple the reservoir to a housing of the infusion device, and a piston located within the fluid chamber. The housing lock structure inhibits axial movement of the reservoir relative to the housing. The piston is movable relative to the body section, and it has a tip section facing the fluid chamber and a base section opposite the tip section. The base section has an actuator lock structure. The piston actuator controls axial movement of the piston within the fluid chamber, and it has a piston lock structure that cooperates with the actuator lock structure to removably couple the piston to the piston actuator.Type: ApplicationFiled: March 15, 2016Publication date: September 21, 2017Inventor: Jacob E. Pananen
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Publication number: 20170266369Abstract: A medical delivery device is provided for delivering a medicinal substance into a user's body. An upper assembly includes a housing having a cavity configured for accommodating a needle. A lower assembly includes a receptacle member having an opening configured for accommodating insertion of the upper assembly, and a base member having an upper body and a recess formed on a top surface of the upper body for receiving the receptacle member. A base pad has an adhesive layer disposed on a lower surface of the pad, and being at least partially attached to a bottom side of the base member. The lower assembly is attached to a skin of the user using the base pad. As the upper assembly transitions from an upper position to a lower position relative to the lower assembly, the needle travels downwardly to penetrate the skin for facilitating administration of the medicinal substance.Type: ApplicationFiled: March 16, 2016Publication date: September 21, 2017Inventors: Dustin Christopher Cawthon, Yuanpang Samuel Ding
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Publication number: 20170266370Abstract: An injection device comprising a housing; a securing arrangement for securing the injection device against an injection site of a patient; a needle insertion mechanism configured to cause insertion of a needle into a patient when the injection device is secured against the injection site of the patient; a medicament delivery arrangement configured to cause injection of a medicament into tissue of the patient at the injection site; and a medicament retention sensor configured to detect retention of medicament in the tissue of the patient at the injection site, wherein the injection device is configured to respond to detection of swelling of the tissue of the patient at the injection site by causing provision of an alert and/or by causing suspension or halting of injection of medicament.Type: ApplicationFiled: September 11, 2015Publication date: September 21, 2017Inventor: Zdenek Cerman