Abstract: A catheter and methods for luminal therapy are provided wherein a catheter includes an elongated catheter shaft having a proximal end and a distal region, a first inflation lumen and a second inflation lumen extending from the proximal end to the distal region; a fluid impermeable balloon affixed to the distal region; an intermediate balloon affixed to the distal region to envelop the fluid impermeable balloon, the intermediate balloon having a first multiplicity of through-wall apertures; and an outer balloon affixed to the distal region to envelop the intermediate balloon, the exterior surface of the outer balloon comprising a coating of an agent; wherein the first inflation lumen is coupled to a first space enclosed by the fluid impermeable balloon, the second inflation lumen is coupled to a second space defined by the fluid impermeable balloon and the intermediate balloon, wherein the fluid impermeable balloon is configured to contact and expand the intermediate balloon against the outer balloon, and to e

Abstract: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

Abstract: The application relates to a medicament carrier which is suitable for the treatment and prevention of pathological conditions in the urogenital region of a person, in particular in the area of the urethra. Said medicament carrier comprises a biocompatible material that cannot melt at the person's body temperature. The medicament carrier is prepared, e.g. at least partially coated, with an active substance or with a mixture of active substances. The medicament carrier is provided with a recovery string (6) for removing same from the body orifice after completion of the treatment. Active substances can be administered generally in the urogenital region using the medicament carrier. The medicament carrier can also be used for microbial reconstitution of the urogenital tract and for sterile catheterization.

Abstract: According to some embodiments, a system for treating skin includes a handpiece assembly comprising a tip and a main body portion, the main body portion comprising an interior cavity and at least one canister configured to store at least one of a treatment material and a waste material. The treatment material and/or the waste material is in fluid communication with the tip.

Abstract: Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.

Abstract: The present invention relates to an apparatus for forming a delivery path for a composition for treatment and an auxiliary assembly for skin treatment including the same, and provides an apparatus for forming a delivery path for a composition for treatment and an auxiliary assembly for skin treatment including the same, the apparatus comprising: a light source; a light irradiating unit for receiving a light from the light source to irradiate the light on a surface of skin; and a control unit for controlling a pulse waveform of a light irradiated through the light irradiating unit so as to form a plurality of pores, which form a path through which a composition applied on the surface of the skin is transferred inside, on the surface of the skin after irradiating the light.

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

Abstract: A microneedle array cartridge includes a web of material having a top face and an opposite bottom face, An adhesive and a microneedle array are disposed on the bottom face of the web of material. A container is disposed relative to the bottom face of the web of material, and has a perimeter portion and a central portion for covering at least part of the microneedle array. At least part of the perimeter portion of the container contacts the adhesive, and the central portion of the container does not contact the adhesive, The perimeter portion and the central portion of the container are integrally formed.

Abstract: A connecting system for connecting a medical tubular line to a medical fluid transfer system, the tubular line including a plug-in component with a first fluid channel and the fluid transfer system including a coupling component with a second fluid channel. The plug-in component can engage in the coupling component to establish a passageway for a medical fluid, which passageway connects the fluid channels to one another. By disposing a first passive transponder in the plug-in component and a second passive transponder in the coupling component at a distance below a predefined threshold value relative to one another, communication of a read/write unit with both transponders via a single antenna is made possible when the plug-in component is engaged in the coupling component so that identification data for the identification of the tubular line and the fluid transfer system stored in the transponders can be read by a read/write unit via a single antenna.

Abstract: The application relates to a connecting element, in particular for connecting vessels and for producing a fluidic connection between vessels or elements joined to the connecting element. The invention also relates to an elastic spring element as a valve element.

Abstract: An electrotherapeutic garment, for example in the form of pants, having at least one electrode portion and an electrically conductive tracer ribbon embedded in the garment for connecting the electrode portion(s) to an electro-stimulation device.

Abstract: Various embodiments of this disclosure concern assembly of a lead having one or two modular lead ends. A modular lead end can be made by aligning a plurality of wires exposed on an end of a main lead body with a plurality of conductors exposed on an end of a lead end. The lead end may comprise a spine, the plurality of conductors circumferentially arrayed about the spine, and an outer surface comprising a plurality of exposed electrical elements and polymer material, the plurality of electrical elements arrayed on the spine and electrically connected with the plurality of conductors. The assembly can further include making electrical connections between the plurality of electrical wires and the plurality of conductors and insulating the plurality of wires and the plurality of conductors.

Abstract: Guidewires and methods for transmitting electrical stimuli to a heart and for guiding and supporting the delivery of elongate treatment devices within the heart are disclosed. A guidewire can comprise an elongate body, including first and second elongate conductors, and at least first and second electrodes. A distal end portion of the elongate body can include a preformed bias shape, such as a pigtail-shaped region, on which the first and second electrodes can be located. The preformed bias shape can optionally be non-coplanar relative to an intermediate portion of the elongate body. The first and second elongate conductors can be formed of a single structure or two or more electrically connected structures. The conductors can extend from proximal end portions to distal end portions that electrically connect to the first and second electrodes.

Abstract: Guidewires and methods for transmitting electrical stimuli to a heart and for guiding and supporting the delivery of elongate treatment devices within the heart are disclosed. A guidewire can comprise an elongate body, including first and second elongate conductors, and at least first and second electrodes. A distal end portion of the elongate body can include a preformed bias shape, such as a pigtail-shaped region, on which the first and second electrodes can be located. The preformed bias shape can optionally be non-coplanar relative to an intermediate portion of the elongate body. The first and second elongate conductors can be formed of a single structure or two or more electrically connected structures. The conductors can extend from proximal end portions to distal end portions that electrically connect to the first and second electrodes.

Abstract: One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slidably coupled to each other and include one or more contacts that are moveably disposed within the slits of the lead bodies. The positions of the one or more contacts can be adjusted to change the direction of stimulation. For example, the positions of the one or more contacts can be adjusted based on theoretically-optimal positions determined from a patient-specific computer model. Parameters of the stimulation applied by the one or more contacts can also be optimized based on the patient-specific computer model.

Abstract: System, method, and tool for implanting an electrode cuff. The system can include a cuff and a slider implement, where the cuff is temporarily retained within and/or onto the slider implement by a retainer mechanism during implantation. The cuff can be structured to exhibit a natural rolled shape, but can be resiliently bendable so as to flex from the rolled shape while having a tendency to move back to the rolled shape. The cuff can be releasably secured to a portion of the slider implement, which may include holding the cuff in an unrolled shape. The cuff can then be positioned adjacent the nerve. The retainer mechanism can then be actuated to allow the cuff to advance towards its naturally rolled shape, thereby wrapping around the nerve.

Abstract: A pulse generator is configured to generate electrical pulses of an electrical stimulation therapy. The pulse generator includes an N number of output channels and a microcontroller configured to generate instructions. The pulse generator is configured to generate different stimulation waveforms simultaneously for the output channels. The different waveforms have different waveform characteristics. A mesh electrode array includes an M number of electrodes. Each of the electrodes is configured to deliver the electrical pulses of the electrical stimulation therapy. M is at least several times greater than N. A solid state relay contains a plurality of controllable switches that is each configured to be turned on or off in response to the instructions received from the microcontroller, such that the solid state relay routes the output channels of the pulse generator to different subset of the electrodes of the mesh electrode array at different points in time.

Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.

Abstract: A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.

Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system.

Abstract: Electro-stimulator (1) includes electrode pad (60) that outputs current to provide electrical stimulation to a muscle, angular velocity sensor (51) that detects information on motion of a waist, and controller (30) that adjusts magnitude of the current output from electrode pad (60) based on a result of the detection by angular velocity sensor (51). Electro-stimulator (1) further includes belt (11) that supports electrode pad (60), angular velocity sensor (51), and controller (30). Thus, current flows through an abdomen, thereby providing electrical stimulation to the abdomen, and enabling proper training of abdominal muscles.

Abstract: An extra-cardiovascular implantable cardioverter defibrillator (ICD) system receives a cardiac electrical signal by an electrical sensing circuit via an extra-cardiovascular sensing electrode vector and senses cardiac events from the cardiac electrical signal. The ICD system detects tachycardia from the cardiac electrical signal and determines a tachycardia cycle length from the cardiac electrical signal. The ICD system determines an ATP interval based on the tachycardia cycle length and sets an extended ATP interval that is longer than the ATP interval. The ICD delivers ATP pulses to a patient's heart via an extra-cardiovascular pacing electrode vector different than the sensing electrode vector. The ATP pulses include a leading ATP pulse delivered at the extended ATP interval after a cardiac event is sensed from the cardiac electrical signal and a second ATP pulse delivered at the ATP interval following the leading ATP pulse.

Abstract: The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

Abstract: An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation.

Abstract: An electrotherapeutic device for treating a visual disease using microcurrent stimulation is provided. The device includes a signal generator in which a waveform controller digitally controls a waveform signal source so as to generate a waveform in which one or more waveform parameters (e.g., pulse width, pulse period, pulse position, pulse coding, peak current amplitude, duty cycle, and/or pulse shape) are varied in accordance with a protocol for treating a visual disease. The device also includes an applicator connected to the signal generator and configured to apply the waveform to at least one stimulation point within an eye region.

Abstract: An electrotherapeutic device for treating a visual disease using microcurrent stimulation is provided. The device includes a signal generator in which a waveform controller digitally controls a waveform signal source so as to generate a waveform in which one or more waveform parameters (e.g., pulse width, pulse period, pulse position, pulse coding, peak current amplitude, duty cycle, and/or pulse shape) are varied in accordance with a protocol for treating a visual disease. The device also includes an applicator connected to the signal generator and configured to apply the waveform to at least one stimulation point within an eye region.

Abstract: A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes, a user interface configured for receiving input from a user that selects one of a plurality of different shapes of a modulating signal and/or selects one of a plurality of different electrical pulse parameters of an electrical pulse train, neuromodulation output circuitry configured for outputting an electrical pulse train to the plurality of electrical terminals, and pulse train modulation circuitry configured for modulating the electrical pulse train in accordance with the selected shape of the modulating signal and/or selected electrical pulse parameter of the electrical pulse train.

Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.

Abstract: A therapeutic neurostimulation system configured for providing therapy to a patient. The neurostimulation system comprises a neurostimulation lead having an array of electrodes arranged along a longitudinal axis configured for being implanted along a spinal cord of a patient, a neurostimulation device configured for delivering electrical stimulation energy to active ones of the electrode array, and control/processing circuitry for instructing the neurostimulation device to configure an active electrode as a cathode, and two active electrodes longitudinally flanking and laterally offset from the cathode as anodes, selecting a ratio of stimulation amplitude values for the two anodes based on a known longitudinal location of the implanted neurostimulation lead relative to the spinal cord, and instructing the neurostimulation device to distribute the electrical stimulation energy between the two anodes in accordance with the selected stimulation amplitude value ratio.

Abstract: Medical devices provide metallic connector enclosures. The metallic connector enclosures may be constructed with relatively thin walls in comparison to polymer connector enclosures to aid in miniaturizing the medical device. The metallic connector enclosures may be constructed with interior surfaces that deviate less from an ideal inner surface shape in comparison to polymer connector enclosures to allow for better concentricity of electrical connectors. The metallic connector enclosures may include a panel that allows access to the cavity of the connector enclosure where set screw blocks, lead connectors, spacers, seals, and the like may be located. Furthermore, the lead connectors within the metallic connector enclosures may be separated from the metallic connector enclosure by being positioned within non-conductive seals that reside within features included in cavity walls of the connector enclosure.

Abstract: Disclosed herein is an implantable electronic device. In one embodiment, the device has a modular header-feedthru assembly and a housing. The modular header-feedthru assembly has a conductor assembly, a feedthru coupled to the conductor assembly, and a polymer header that is injected molded about the conductor assembly and at least a portion of the feedthru. The housing is welded to the feedthru.

Abstract: One embodiment provides a power supply device for supplying power to a medical device main body implanted in a human body. The power supply device includes a power supply coil configured to supply power wirelessly to a power reception coil provided in the medical device main body from outside the human body through electromagnetic induction. And, the power supply coil includes: a cylindrical coil formed by winding a lead wire helically; and a ring-shaped member made of a magnetic material and is disposed so as to surround an outer circumference of the cylindrical coil.

Abstract: A medical system is disclosed, comprising internal parts for implantation in a patient and external part for use externally to the patient. The external parts comprise an energy source equipped with a primary coil and an external control unit for controlling the energy source. The internal parts comprise an electrically powered medical device, an energy receiver equipped with a secondary coil and an internal control unit for controlling the internal parts. The system is arranged to determine a balance between the amount of energy received in the energy receiver and the amount of energy used by the medical device, based on a first, second and third parameter.

Abstract: Flexible subcutaneous implantable medical device (IMD), including an elongated and flexible body, a plurality of electronic components, at least one rechargeable battery, at least one antenna, at least one lead and at least one transition unit, the antenna for receiving and transmitting electromagnetic radiation and the lead for providing an electric shock, wherein the elongated and flexible body is structured from a plurality of units, wherein a first one of the plurality of units encapsulates the rechargeable battery, wherein each one of the other plurality of units respectively encapsulates a respective one of the plurality of electronic components, wherein the antenna is positioned in the transition unit, wherein the transition unit is covered with a biocompatible polymer, wherein the antenna receives electromagnetic radiation for recharging the rechargeable battery and wherein the antenna includes a copper coil having a generally cylindrical shape.

Abstract: An example of a system for delivering neurostimulation may include a display and an interface control circuit. The interface control circuit may be configured to define a stimulation waveform according to which the neurostimulation is delivered. The stimulation waveform is defined by waveform parameters including one or more user-adjustable parameters. The interface control circuit may include a parameter selector, an effect analyzer, and a parameter generator. The parameter selector may be configured to present values for each user-adjustable parameter on the display and allow the user to select a value for each user-adjustable parameter from the presented values. The effect analyzer may be configured to estimate an interactive effect of different stimuli of the neurostimulation. The parameter generator may be configured to select a rate rule based on the estimated interactive effect and to generate the values for each user-adjustable parameter according to the selected rate rule.

Abstract: In embodiments, a wearable cardiac defibrillator system includes an energy storage module configured to store a charge. Two electrodes can be configured to be applied to respective locations of a patient. One or more reservoirs can store one or more conductive fluids. Respective fluid deploying mechanisms can be configured to cause the fluids to be released from one or more of the reservoirs, which decreases the impedance at the patient location, and decreases discomfort for the patient. In some embodiments an impedance is sensed between the two electrodes, and the stored charge is delivered when the sensed impedance meets a discharge condition. In some embodiments, different fluids are released for different patient treatments. In some embodiments, fluid release is controlled to be in at least two doses, with an intervening pause.

Abstract: The application discloses a number of methods and apparatuses suitable for selective skin treatment have been described. In one example, a pair of RF electrodes is applied to skin. The RF electrodes receive RF energy from an RF energy generator. The RF electrodes are also configured to apply positive pressure to a segment of skin located between the pair of RF electrodes to partially or completely occlude the blood flow in one or more vessels in the segment of skin located between the pair of RF electrodes. Occlusion of the blood flow reduces heat dissipation by the skin segment located between the pair of RF electrodes and supports further increase of temperature of both the skin segment and vessels located between the pair of electrodes.

Abstract: An apparatus and method for electromagnetic treatment of plants, animals, and humans comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said target pathway structure using a coupling device.

Abstract: Apparatus and methods for simultaneously providing an infra-red laser beam and a concentrated uni-polar, pulsed electromagnetic field to a region of interest in the body of a patient are disclosed. The apparatus produces the infrared laser beam from a laser diode and the pulsed electromagnetic field from an electrically conductive coil. The infra-red laser beam and the pulsed electromagnetic field are produced concurrently along a common axis. A focusing magnet is provided to concentrate the lines of flux so that they extend along the laser beam. The apparatus includes a body of Mu-metal shielding surrounding the components of the apparatus except for one pole of the coil from which the lines of flux of the electromagnetic field extend to further concentrate the field and render it effectively uni-polar.

Abstract: A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 Hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain.

Abstract: In accordance with various aspects of the present teachings, systems and methods for applying treatment energy, e.g., electromagnetic radiation such as laser radiation in the visible and near infrared wavelengths, to body areas having bulges and fat deposits, loose skin, pain, acne and/or wounds. In some aspects, the systems and methods can enable relatively lengthy treatments to be performed by having the practitioner set-up and/or start the treatment, thereafter allowing the treatment to proceed safely and effectively without the continued presence of the practitioner.

Abstract: System includes a beam generator to generate beam(s) for patient treatment and a computing device that obtains three-dimensional image(s) of a target structure that repositions with respect to surrounding tissue of the patient. The computing device creates plan(s) including a first three-dimensional probability distribution of patient's position and a second three-dimensional probability distribution of the repositioned structure's internal position. The computing device combines the first distribution with the second distribution to generate a joint distribution and selects a probability level from the joint distribution. The probability level defines an enclosed surface. A distance defined between the surface and a point of origin in at least one direction is equal to a threshold value of a parameter of the repositioned target in the direction.

Abstract: An x-ray apparatus includes a source configured to generate electrons, a target configured to produce x-rays upon impingement of electrons, and a detector configured to detect electrons penetrating the target or reflected from the incident face of the target, indicative of damage to the target.

Abstract: A detector for measuring scanning ion beams in radiation therapy sequentially includes a first high voltage electrode, a first spacing member, and a segmented electrode. The first spacing member is connected to the first high voltage electrode and the segmented electrode to form a first ionization cavity. The first ionization cavity is formed with a plurality of first reading electrodes and a plurality of second reading electrodes therein. A second spacing member and a second high voltage electrode are further sequentially disposed. The second spacing member is connected to the second high voltage electrode and the segmented electrode to form a second ionization cavity. The first reading electrodes and the second reading electrodes are respectively formed in the first ionization cavity and the second ionization cavity. With the first reading electrodes and the second reading electrodes in different directions, highly accurate space resolution, space dosage and scanning speed are achieved.

Abstract: A method of changing the volume of an intra-bilayer membrane space of at least one bilayer membranous structure of a target tissue. The method comprises providing at least one characteristic of a target tissue having at least one bilayer membranous structure, selecting an acoustic energy transmission pattern set to change a volume of an intra-bilayer membrane space of a bilayer membrane of the at least one bilayer membranous structure according to the at least one characteristic, and applying acoustic energy on the target tissue according to the selected acoustic energy transmission pattern.

Abstract: The invention relates to a cosmetic product comprising a) a cosmetic preparation containing, in relation to its total weight, a1) from about 60 to about 98 wt % of at least one polar solvent; a2) from about 0.1 to about 20 wt % of at least one copolymer from the monomers i) n-tert-butylacrylamide, ii) acrylic acid, iii) ethyl acrylate, iv) and optionally other monomers; b) a device for flash evaporation of the cosmetic preparation a), and to a method using corresponding products and to the use of the cosmetic preparation a) as process material in a device for flash evaporation.

Abstract: Disclosed is a cosmetic product comprising a) a cosmetic preparation that has a viscosity of 5,000 to 1,000,000 mPas and contains, in relation to the total weight of the preparation, a1) 60 to 98 wt % of at least one polar solvent; a2) 0.01 to 10 wt % of at least one thickener; b) a device for flash evaporating cosmetic preparation a). Also disclosed are a method using corresponding products and the use of cosmetic preparation a) as a process material in a flash evaporation device.

Abstract: The present disclosure relates to agents for dyeing keratin fibers, in particular human hair, containing, in a cosmetic carrier (a) at least one direct dye of formula (I), wherein Het 1, Het 2 represent a cationic heterocycle, and A1, A2, independently of one another, represent a grouping of formulas (VIII) or (IX), wherein n represents a whole number of between 2-6, and m, p, independently of one another, represent the numbers 2 or 3.

Abstract: The present disclosure relates to agents for dyeing keratin fibers, in particular human hair, containing, in a cosmetic carrier, (a) at least one direct dye of formula (I), and (b) at least one anionic surfactant.

Abstract: The invention relates to a personal care cream composition, more particularly to a photo-protective composition that maintains its sensory properties while ensuring high sun-protection efficacy. The present inventors have herein determined that inclusion of hydrophobic polymer particles of a specified particle size range enables certain cream compositions to not only provide the sunscreen benefits but also deliver the excellent watery sensation the consumers have come to expect from such compositions.