Abstract: Described herein is a method of modulating sumoylation of a Ras protein by small ubiquitin-like modifier (SUMO) proteins. Provided herein is a method for regulating the activity of a Ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant Ras protein that is associated with the proliferative disease. Described herein is a modified Ras protein. Described herein are recombinant vectors, cells comprising the vectors expressing the modified Ras proteins. Provided herein is an antibody that specifically binds to a sumoylated Ras protein. Described herein is a method for identifying an agent that interferes with the sumoylation of a Ras protein. Also described herein are therapeutic and prophylactic compositions. Also provided herein is a method of using a modified Ras protein to replace an endogenous mutant Ras protein that is associated with a proliferative disease.

Abstract: There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that bind CD38, CD38-antibody binding fragments and derivatives of such antibodies, and CD38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the variant scFv has one or more insertions, deletions, or substitutions relative to a corresponding 3E10 scFv, and wherein the molecule can bind, preferably specifically bind, to the epitope of 3E10. Methods of using the antigen binding molecules for treating cancer and viral infections or preventing viral infections are also provided.

Abstract: The method of making nanocrystalline cellulose is a flash lyophilized-acidic hydrolysis method for converting cellulosic fibers into nanocrystalline cellulose. Cellulosic fibers are initially ground in a high-speed, rotary grinder to produce ground cellulose fiber. The ground cellulose fiber is then dried to produce dried, ground cellulose, which is then freeze-dried to yield lyophilized cellulose. Pure concentrated sulfuric acid is then added to the lyophilized cellulose at a liquid/solid ratio of 1:1 (vol/wt) to form a cellulosic paste. The cellulosic paste is diluted in either water or absolute ethanol at a liquid/solid ratio of 1:1 (vol/wt) to form a cellulosic solution, which is then filtered under cooling by liquid nitrogen-vapor. The nanocrystalline cellulose precipitate is then washed until neutralization and dried to yield nanocrystalline cellulose.

Abstract: Enantiomers of butanediol diglycidyl ether (BDDE) are present in an enantiomerically enriched enantioenriched mixture of BDDE stereisomers or in an enantiomerically pure BDDE. Enantiomerically enriched or pure BDDE is useful as a cross-linking agent, such as in the preparation of a cross-linked hyaluronic acid product.

Abstract: A radical polymerization method that enables synthesis, at a high conversion rate, of polymers having a relatively uniform molecular weight and is applicable to various monomers, and an apparatus used for the method. A reaction solution containing monomer and initiator is continuously or intermittently circulated in the apparatus and is heated in a heating-initiation unit to a predetermined temperature simultaneously across a radial direction of a cross section of the flow path whereby the initiator located in a particular volume of the reaction solution is cleaved all at once. The apparatus includes a heating medium production unit 10, a heating medium-reaction solution mixing unit 20, a cooling unit 30, and a recovery unit 40 for a reaction mixture, all communicatively connected by the flow path and optionally a heating reaction unit 60, a cooling unit 70, and a recovery unit 80, all communicatively connected by the flow path.

Abstract: The invention relates to an aqueous coagulatable polymer dispersion comprising at least one polymer which is dispersed in an aqueous phase, thermoplastic micro-spheres which contain a propellant, and at least one additional component which is selected from the group consisting of polyols, polyamines, and thermoplastic polymers. The invention further relates to a coagulate which can be obtained by the thermal and/or mechanical and/or ultrasonically-initiated coagulation of the aqueous polymer dispersion according to the invention, to an adhesive comprising or consisting of the coagulate, to a substrate which is completely or partly coated with said coagulate, to a method for producing such a coated substrate, and to coated substrates which can be obtained using said method. The coagulate can be used as an adhesive or as a binder in 3D-printing methods.

Abstract: The present invention is a hydrogenated block copolymer obtained by hydrogenating a block copolymer [C] that comprises polymer blocks [A] and polymer block [B], a ratio (wA:wB) of a weight fraction wA of the polymer blocks [A] and a weight fraction wB of the polymer block [B] in the block copolymer [C] being 45:55 to 65:35, a ratio (w[IB]:w[IIB]) of a weight fraction w[IB] of the repeating unit [I] derived from an aromatic vinyl compound and a weight fraction w[IIB] of the repeating unit [II] derived from a linear conjugated diene compound in the polymer block [B] being 40:60 to 55:45, 90% of more of unsaturated bonds included in the block copolymer [C] having been hydrogenated, a weight average molecular weight of 60,000 to 150,000, a low-temperature-side glass transition temperature [Tg1] of 0° C. or more and a high-temperature-side glass transition temperature [Tg2] of 135° C. or more, and a stretched film.

Abstract: Embodiments of the disclosure generally provide compositions and methods involving the reaction extrusion of flame retardant polyhydroxyalkanoates with renewable resource content.

Abstract: There is provided a polyolefin resin foam sheet having a plurality of cells which is formed by foaming a polyolefin resin composition, wherein the polyolefin resin composition contains a polyolefin resin (A) having relatively high density and a polyolefin resin (B) having relatively low density, and the weighted average resin density of the polyolefin resin (A) and the polyolefin resin (B) is 0.900 g/cm3 or less; and wherein a ratio [TD strength at break/MD maximum cell size] and a ratio [MD strength at break/TD maximum cell size] are both 45 kPa/?m or more.

Abstract: The present invention relates to a polyolefin which exhibits a narrow molecular weight distribution, high strength, and a high stretching ratio, and a preparation method therefor. According to the present invention, it is possible to provide polyethylene with high catalyst activity, high molecular weight, and controlled molecular weight distribution by using, in polymerization of an olefin monomer, a hybrid supported metallocene catalyst in which a borate compound is used as a second cocatalyst. In addition, if the polyolefin is processed, it is possible to produce a fiber with excellent mechanical properties and an excellent stretching ratio.

Abstract: A method for producing a polyolefin is provided. The method includes a step of feeding a polyolefin powder having a catalytic activity into a gas phase polymerization vessel in which there is a polyolefin powder and through which a gas comprising an olefin is being circulated, thereby commencing polymerization of an olefin. The following formula (1) is satisfied: 0.5<?/(?B)<24.0??(1) In formula (1), ? represents the median diameter (?m) of the catalytically active polyolefin powder to be fed into the vapor phase polymerization vessel, ? represents the median diameter (?m) of the polyolefin powder that is contained in the vapor phase polymerization vessel before the feeding of the catalytically active polyolefin powder into the vapor phase polymerization vessel, and B represents the linear gas velocity (m/sec) of the gas containing an olefin within the vapor phase polymerization vessel.

Abstract: A functional polymer including at least two different types of side chains, having the general formula (1), wherein A is an at least monosubstituted alkylene or arylene group; B is an amide, ester or ether group and n is 0 or 1; F is selected from: an ester, secondary amine, amide, ether, thio ether, thio ester, and may be the same or different for the different side chains; D is a side chain intended to reversible bind to a substrate or has a coating function; E is a side chain intended to irreversible bind to a substrate, the side chain E and polymer includes 1 to 10 different side chains D and 1 to 10 different side chains E, but at least one of each, and includes a plurality of each type, whereby the different types of side chains are randomly or regularly distributed in the polymer.

Abstract: The present disclosure provides an article of manufacture made from or containing a propylene-based terpolymer, having (i) ethylene-derived units in the range from about 0.5 wt. % to about 1.8 wt. %; (ii) 1-butene-derived units in the range from about 1.5 wt. % to about 2.5 wt. %; (iii) a ratio of C2 wt %/C4 wt % in the range from about 0.40 to about 0.80, wherein C2 wt % is the weight percent of ethylene-derived units and C4 wt % is the weight percent of 1-butene-derived units; (iv) a melt flow rate in the range from about 30 g/10 min to about 80 g/10 min; (v) a xylene soluble fraction at 25° C. lower than about 5.0 wt. %; and (vi) a melting point higher than about 140° C. The article can be a container, which can be used for food applications.

Abstract: Catalyst activators and methods for their preparation and their use in processes for polymerizing olefms are described. In particular, catalyst activators derived from aluminum alkyls and their use with metallocene type catalyst systems and/or conventional-type transition metal catalyst systems are described.

Abstract: The present invention relates to a vinyl chloride-based polymer containing an unsaturated fatty acid ester at a specific ratio, a method for preparing the same, a thermoplastic resin composition containing the same, and a thermoplastic resin molded article produced from the composition. The vinyl chloride-based polymer may have good processability, and thus, the thermoplastic resin molded article produced from the thermoplastic resin composition containing the vinyl chloride-based polymer may have high impact strength and improved appearance characteristics.

Abstract: Provided are a vinyl chloride-based copolymer, as a secondary particle in which primary particles are assembled, which may exhibit excellent mechanical properties and transparency as well as excellent plasticity by having an average pore diameter of 100 nm or less and a porosity of 40 vol % or less, including 65 wt % to 97 wt % of a vinyl chloride-based monomer-derived repeating unit; and 3 wt % to 35 wt % of cis and trans isomers of an unsaturated fatty acid ester-derived repeating units, and including the repeating units respectively derived from the cis and trans isomers of the unsaturated fatty acid ester in a weight ratio of 60:40 to 99:1, and a method of preparing the same.

Abstract: There is provided a carboxyl group-containing polymer composition having excellent water solubility and aqueous solution-thickening properties, having a minimal change in viscosity due to the thermal history in a drying step, and having high transparency of a neutral viscous solution obtained by mixing with water. The carboxyl group-containing polymer composition comprises (A) a carboxyl group-containing polymer obtained by copolymerization of an ?,?-unsaturated carboxylic acid (a1) and a compound (a2) having at least two or more ethylenically unsaturated groups per molecule; (B) a polyhydric alcohol fatty acid ester alkylene oxide adduct; and (C) a polyoxyalkylene modified product, which is at least one of an ether (c1) of a polyoxyalkylene with a fatty alcohol, and a polyoxyalkylene fatty acid ester (c2).

Abstract: The cis-1,4 mer content of conjugated diene mer in polymers can be increased by adding any of a class of morpholine compounds to a catalyst composition that includes a lanthanide metal atom.

Abstract: A process of forming a macromolecular block copolymer includes forming a first high molecular weight polymer using a first extruder of an extruder system that includes multiple extruders. The first extruded high molecular weight polymer has a first length terminating at a joiner of the extruder system and has a first set of material properties along the first length. The process also includes forming a second high molecular weight polymer using a second extruder of the extruder system. The second extruded high molecular weight polymer has a second length terminating at the joiner of the extruder system and has a second set of material properties along the second length. The process further includes bonding the first extruded high molecular weight polymer to the second extruded high molecular weight polymer to form a macromolecular block copolymer having a first segment of the first length and a second segment of the second length.

Abstract: A process of forming a macromolecular block copolymer includes forming a first high molecular weight polymer of a first length. The first high molecular weight polymer includes a first set of side-chain functional groups and has a first characteristic rigidity value along the first length. The process also includes forming a second high molecular weight polymer of a second length. The second high molecular weight polymer includes a second set of side-chain functional groups and has a second characteristic rigidity value along the second length that is less than the first characteristic rigidity value. The process further includes bonding the second high molecular weight polymer to the first high molecular weight polymer.

Abstract: Disclosed herein is an aerogel made from a polyhydroxy benzene compound crosslinked with formaldehyde. The aerogel is dry and has a first volume and wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.

Abstract: The present invention relates to a method for manufacturing thermoplastic polyurethane pellets by means of reactive extrusion of: a long macrodiol with a molecular weight of 500 to 3000 g/mol; a diisocyanate; at least one chain extender comprising a dianhydrohexitol; and a polymerization catalyst. The invention also relates to the resulting thermoplastic polyurethane pellets.

Abstract: The polymer comprises units of formula (I) and of formula (Ibis), being comprised the molar ratio between units (I) and (Ibis) comprised from 1.0:0.2 to 1.0:0.8, and wherein R4 are independently selected from radicals of formula (II), (III), and (IV), R1 and R1? are independently selected from: —H, (C1-C20)alkyl, (C5-C14)aryl, —OR5, —(CO)R6, —O(CO)R7, —(SO)R8, —NH—CO—R9, —COOR10, —NR11R12, —NO2, and halogen; R2, R2?, R3, and R3? are —H; P is a polymeric chain, R5 to R12 are independently selected: —H, (C1-C20)alkyl, and (C5-C14)aryl;R13 and R14 are independently selected from (C1-C5)alkyl, and (C5-C14)aryl;, m is from 3 to 4; n is from 1 to 2; and p is from 1 to 2 provided that n+m+p sums 6; the polymer comprising from 5 to 25 weight % of urea moieties, and having H-bonding and pi-pi staking interactions between the urea groups, and a tensile strength comprised from 3 to 15 MPa.

Abstract: The disclosure generally provides methods of making natural oil-derived polyol compounds from compositions that include self-metathesized oligomers of natural oils, including methods of using such polyols to make polyurethane compositions, such as polyurethane foams.

Abstract: Disclosed is a photosensitive resin composition for an optical waveguide containing a resin component and a photoacid generator. In the photosensitive resin composition, the resin component is constituted of an epoxy resin component containing both an aromatic epoxy resin and an aliphatic epoxy resin, and the content of the aromatic epoxy resin is 55 wt. % or more and less than 80 wt. % of the entirety of the epoxy resin component and the content of the aliphatic epoxy resin is more than 20 wt. % and 45 wt. % or less of the entirety of the epoxy resin component. Accordingly, for example, when a core layer of an optical waveguide is formed using the disclosed photosensitive resin composition for an optical waveguide, a core layer of an optical waveguide having satisfactorily low tackiness and high transparency while maintaining satisfactory roll-to-roll compatibility and a high resolution patterning property can be formed.

Abstract: Provided are: an epoxy resin composition for fiber-reinforced composite materials, which has a good balance between storage stability and fast curing properties at high levels; a prepreg; and an epoxy resin composition which exhibits excellent mechanical characteristics as a fiber-reinforced composite material. A resin composition which contains an epoxy resin, dicyandiamide, an imidazole compound and an acidic compound, while satisfying the following conditions (a)-(c): (d) The time until the heat flow rate reaches the peak top after the epoxy resin composition reaches 100° C. is 25 minutes or less as measured by a differential scanning calorimeter at an isothermal temperature of 100° C. in a nitrogen gas stream. (e) The time until the heat flow rate reaches the peak top after the epoxy resin composition reaches 60° C. is 15 hours or more as measured by a differential scanning calorimeter at an isothermal temperature of 60° C. in a nitrogen gas stream.

Abstract: Disclosed is a polymer powder having an average particle diameter of 20 ?m to 300 ?m, with a particle diameter of less than 10 ?m of 10 mass % or less, and a particle diameter of greater than 300 ?m of 10 mass % or less. Further, disclosed is a method for preparing a polymer powder, comprising: forming a melt of a polymer; introducing a supercritical fluid into the melt of the polymer to form a mixed composition; and spraying the mixed composition to prepare the polymer powder.

Abstract: The invention relates to a multilayer biaxially oriented polyester film comprising a base layer B, an amorphous outer layer A and a further outer layer C, where this polyester film is suitable for lamination with metal sheets. The invention in particular relates to a polyester film which comprises (based on the mass of polyester) from 2 to 15% by weight of isophthalate-derived units in the base layer and which comprises more than 19% by weight of isophthalate-derived units in the amorphous layer A, and which has a silane-based coating on the outer layer A. The invention further relates to a process for the production of these films.

Abstract: An object of the invention is to provide a resin which does not need to incorporate a fluorescent substance and exhibits fluorescence itself. Another object of the invention is to provide a liquid crystal polymer which does not contain a bleeding out substance such as hydrophobic silica and barium sulfate and which has an effect of suppressing fibrillation in the resin itself. The invention relates to a liquid crystal polymer comprising a copolymer of a polymerizable monomer (A) selected from the group consisting of pyromellitic acid or anhydride thereof and a reactive derivative thereof and an other polymerizable monomer (B).

Abstract: The present invention relates to a linear or branched structured hydroxylated or carboxylated polyester resin that is free of unsaturated fatty acids, that is made from an acid component and an alcohol component, said acid component comprising at least one C4 to C6 carboxylic polyacid or anhydride, and at least one C5 to C54 carboxylic polyacid or anhydride, and with said alcohol component comprising at least one biobased polyol having a functionality of at least 2 bearing a 1,4:3,6-dianhydrohexitol unit, and at least one of two polyols b2) and b3).

Abstract: The present invention relates to a method for manufacturing a water treatment separation membrane, the method including: forming an aqueous solution layer including an amine compound on a porous support; and bringing an organic solution including an acyl halide compound into contact with on the aqueous solution layer to form a polyamide active layer, in which the organic solution includes a non-polar solvent and an amphiphilic solvent having a boiling point of 120° C. or more, thereby improving a permeation flux, and a water treatment separation membrane manufactured by the manufacturing method.

Abstract: A tire including a tire skeleton body that is made of a resin material containing a polyamide-based thermoplastic elastomer and has a ring shape, wherein the polyamide-based thermoplastic elastomer includes a hard segment, a soft segment consisting of a constituent unit derived from polypropylene glycol, and a binding portion that binds two or more segments and that consists of a constituent unit derived from a dicarboxylic acid of from 6 to 20 carbons, the polyamide-based thermoplastic elastomer having a weight average molecular weight of from 20,000 to 250,000.

Abstract: wherein: R1 is selected from H, an alkyl group, an aryl group, and combinations thereof; R2 is Rf—(CH2)x—; R3 is selected from a vinyl group, a vinylether group, a (meth)acryloyloxy group, a (meth)acryloylamino group, a trialkoxysilylalkylthio group, and a trialkoxysilylalkylamino group; Y is selected from a bond, and —(CH2CH2O)y—; n is greater than 10; x is 2 to 20; and y is at least 1.

Abstract: A difunctional polyhedral oligomeric silsesquioxane derivative and synthesis of the present invention is disclosed. The difunctional polyhedral oligomeric silsesquioxane derivative is represented by following formula (I), wherein R is selected from one of The synthesis of the difunctional polyhedral oligomeric silsesquioxane derivative includes obtaining bis-PA-DDSQ compound though addition reaction of DDSQ compound and 4-acetoxystyrene, obtaining bis-Ph-DDSQ compound though hydrolytic reaction of bis-PA-DDSQ compound and hydrazine, and obtaining bis-AlBz-DDSQ compound though cycloaddition reaction of bis-Ph-DDSQ compound and paraformaldehyde.

Abstract: Organofunctional polyorganosiloxanes, their use in cosmetic compositions, method for treating amino acid based substrates with organofunctional polyorganosiloxanes, compositions comprising the organofunctional polyorganosiloxanes useful for hair straightening and shaping as well as hair coloration and hair color retention.

Abstract: This invention relates to a process for forming a long-chain branched polymer and a long-chain branched polymer resulting from the process. The process comprises reacting (a) a polyolefin base polymer with (b) a coupling agent comprising a polymeric coupling agent, optionally blended with a molecular coupling agent, the polymeric coupling agent being a modified polyolefin having a reactive coupling group at one or more terminal ends of the modified polyolefin chain, to couple the polyolefin base polymer (a) with the coupling agent (b) to form a long-chain branched polymer having a long-chain branching and/or higher surface energy relative to the polyolefin base polymer.

Abstract: A thermoplastic elastomer (TPE) resin powder includes spherical particles of a thermoplastic elastomer resin that have an average particle diameter of 50 ?m to 300 ?m.

Abstract: One aspect of the present invention provides an end-modified conjugated diene polymer represented by Formula 1 below: wherein p is a conjugated diene polymer chain; R1 to R7 are each independently C1-C20 saturated or unsaturated hydrocarbon chains; X is carbon (C), silicon (Si), or nitrogen (N); a is 1 or 2; and n is an integer of 1 to 200, and a method for preparing the same.

Abstract: Embodiments of the present technology may include a carbohydrate binder composition. The carbohydrate binder composition may include a carbohydrate, a nitrogen-containing compound, and a catalyst. The catalyst may catalyze a reaction between the carbohydrate and the nitrogen-containing compound. The catalyst may be water soluble in the composition but may become water insoluble after curing the composition.

Abstract: A system and method for reducing draw resonance of plastic material in the molten state, so-called melt, leaving an extrusion group of a plant for the production of plastic film, includes at least one thermostatically-controlled cylinder, having an embracement angle, of the melt on the cylinder, adjustable on the basis of the process rate, i.e. the linear movement speed of the plastic film, and/or on the basis of the temperature measured in the proximity of or in correspondence with the clamping area of the melt in a thermoforming, calibration and cooling group included in the plant and positioned downstream of the system.

Abstract: The polymer film of the present invention has through holes extending from one principal surface of the polymer film to the other principal surface of the polymer film. The through holes are straight holes having a central axis extending straight, and have a shape in which the area of a cross-section perpendicular to the direction of the central axis increases from the one principal surface of the polymer film toward the other principal surface. This polymer film has passages in its thickness direction, has an unconventional structure, and can be used in various applications, such as in a waterproof sound-permeable membrane, in a waterproof gas-permeable membrane, and in a suction sheet. The ratio a/b of the opening diameter a of the through holes at the one principal surface to the opening diameter b of the through holes at the other principal surface is 80% or is less than 80%.

Abstract: The instant invention provides a multilayer structure comprising: (a) a substrate, wherein said substrate is optionally surface treated on at least one surface and has a surface energy in the range of at least 32 dyn, (b) a sealing layer derived from the application of one or more aqueous dispersions to at least a portion of said at least one surface of said substrate, and wherein the one or more aqueous dispersion comprise the melt kneading product of: (a) one or more a base polymers selected from the group consisting of ethylene and optionally one or more ?-olefins, propylene and optionally one or more ?-olefins; (b) one or more a stabilizing agents; (c) in the presence of a neutralizing agent and (d) water.

Abstract: There is provided a polyolefin resin foam sheet having a plurality of cells which is formed by foaming a polyolefin resin, wherein, in the polyolefin resin foam sheet, the average cell sizes and the maximum cell sizes in the MD direction and the TD direction are each a predetermined value, and a ratio [TD strength at break/MD average cell size] and a ratio [MD strength at break/TD average cell size] are both 80 kPa/?m or more.

Abstract: Disclosed are a polyurethane composition, a molded article, and a vehicle comprising the polyurethane composition or the molded article. The polyurethane composition comprises a polyol composition (A) in which polyether polyol (a1) and polymer polyol (a2) are mixed at a predetermined amount, an isocyanate composition (B) obtainable by polymerizing polyether polyol (b2) and an isocyanate composition (b1) that comprises i) methylene diphenyl isocyanate (M-MDI) and ii) polymethylene diphenyl isocyanate (P-MDI). As such, the molded article such as a vehicle seat pad can be manufactured with improved static and dynamic comfort.

Abstract: Products and methods for producing products which comprise polyethylene and inorganic minerals for a single layer plastic composition.

Abstract: The invention relates to a plasticizer composition containing at least one polymer dicarboxylic acid ester, to molding compounds containing a thermoplastic polymer or a elastomer and a plasticizer composition of said type, and to the use of said plasticizer compositions and molding compounds.

Abstract: Provided herein are compositions comprising at least one estolide compound of formula: in which n is an integer equal to or greater than 0; m is an integer equal to or greater than 1; R1, independently for each occurrence, is selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; and R3 and R4, independently for each occurrence, are selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched. Also provided are uses of the compositions described herein.

Abstract: A method for manufacturing a rubber composition includes kneading a rubber component, an inorganic filler and a thioester-based silane coupling agent, and adding a vulcanizing agent and one or more compounds selected from the group of an imide compound and an N-oxyl compound to a mixture of the rubber component, the inorganic filler, and the thioester-based silane coupling agent such that the vulcanizing agent and the imide compound and/or the N-oxyl compound are kneaded with the mixture including the rubber component, the inorganic filler, and the thioester-based silane coupling agent.