Abstract: The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3? target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3? target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions.

Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

Abstract: The invention provides to methods for diagnosing eye-length related disorders, including myopia. The invention also provides methods for treating and limiting eye-length related disorders, including myopia. In addition, the invention provides certain haplotypes associated with eye-length related disorders, including myopia and Bornholm Eye Disease.

Abstract: Methods of detecting or predicting the presence of colorectal neoplasia are described based on the amounts of particular miRNAs in plasma.

Abstract: The invention is related to a method of determining whether an individual suffering from cancer is likely to respond to anti-EGFR and/or EGFR pathway therapy. In one aspect, the invention utilizes the expression level of a set of genes for determining said response. In a further aspect, the invention relates to a method of assigning treatment to an individual suffering from cancer.

Abstract: The present invention provides a method of diagnosing a breast cancer central nervous system (CNS) metastasis in a subject, comprising determining the expression level of at least one biomarker in a subject-derived brain or breast tissue comparing the subject-derived expression level with a normal control level obtained from normal brain or breast cells; and correlating an increase or decrease of the subject-derived expression level as compared to the normal control level to a diagnosis of a breast cancer CNS metastasis. The present invention also provides a method for the treatment of a breast cancer CNS metastasis in a subject comprising administering to the subject an inhibitor of an overexpressed gene associated with CNS metastasis.

Abstract: The present invention provides a primer set and a kit containing same for analyzing a sequence of an MLH1 DNA, an MLH1 mRNA, and/or a cDNA sequence derived from said MLH1 mRNA of a subject to identify a V384 alteration of an MLH1 gene encoded protein.

Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: Herein is reported a method for producing an enzymatic conjugation product of two polypeptides comprising incubating of a first polypeptide comprising the amino acid sequence LPXTG (SEQ ID NO: 20, wherein X can be any amino acid residue), a second polypeptide has an oligo-alanine Am (m=2 (SEQ ID NO: 26), or 3 (SEQ ID NO: 27), or 4 (SEQ ID NO: 28), or 5 (SEQ ID NO: 29)) amino acid sequence at its N-terminus, a third polypeptide with sortase activity which is derived from Staphylococcus aureus Sortase A, and recovering the conjugate from the reaction mixture and thereby producing the enzymatic conjugation product of two polypeptides.

Abstract: The present invention relates to a process for generating glucose and glucose derivatives from the direct contacting of cellulose, hemicelluloses and/or polysaccharides with a mixed super critical fluid system of alcohol and water whereby the partial pressure of the system provides for both alcoholysis and hydrolysis of the material to generate primarily glucose, and glucose derivatives.

Abstract: A method for mitigating the buildup of direct reduced iron (DRI) clusters on the walls of a direct reduction (DR) furnace, comprising: injecting one or more of lime, dolomite, and another anti-sticking agent into a charge disposed within a reduction zone of the DR furnace, wherein the one or more of lime, dolomite, and another anti-sticking agent is injected into the charge by one or more of: (1) injecting the one or more of lime, dolomite, and another anti-sticking agent into a bustle gas stream upstream of a bustle of the DR furnace; (2) injecting the one or more of lime, dolomite, and another anti-sticking agent into the bustle gas stream in the bustle of the DR furnace; (3) injecting the one or more of lime, dolomite, and another anti-sticking agent into the bustle gas stream through a pipe collocated with a bustle gas port through which the bustle gas stream is introduced into the DR furnace; and (4) injecting the one or more of lime, dolomite, and another anti-sticking agent directly into the reduction

Abstract: A metal piece for a motor vehicle has a generally elongated shape according to a longitudinal direction. The piece includes at least one edge extending according to the longitudinal direction, at the intersection of two walls of the piece, and at least one area having a mechanical strength lower than the rest of the body of the piece, wherein the at least one area is formed through local thermal control of the piece. The lower mechanical strength area of the piece undulates along the edge, extending alternatingly along each of the walls forming the edge. A method for making the metal piece is also disclosed.

Abstract: A control system for heat treatment of a stainless steel part in a furnace having an internal heat treatment chamber with a treatment atmosphere therein arranged in a plurality of zones, the system including at least one analysis apparatus for each one of the plurality of zones, each analysis apparatus in communication with a respective one of the zones for providing a gas to said zone, analyzing an atmosphere of said zone, and sensing a temperature of said zone for determining commencement of nitriding in the treatment atmosphere. A related furnace is also provided.

Abstract: A steel product bent by heating to 600° C. or more, specifically a heat treated steel product having high strength and excellent chemical conversion coating ability which has scale with FeO content of 90% or more, having a thickness of 1 ?m or less on the surface.

Abstract: A method for heat treating a steel component. The steel component is disposed in a heat treating furnace. The steel component is then exposed to a nitriding atmosphere at a predetermined nitriding temperature for a predetermined nitriding time interval. The nitriding atmosphere has a predetermined composition. The composition of the nitriding atmosphere is controlled while the steel component is exposed thereto. The steel component is slowly cooled to ambient temperature and then removed from the heat treating furnace. The heat treated steel component has substantially increased corrosion and wear resistance compared to the steel component prior the heat treating.

Abstract: With respect to ceramic filters and filter systems for continuous metal melt filtration, to be able to counter high throughputs of steel melt and also the limitations of filter capacities during continuous casting, an alternative technological approach involves the use of novel, replaceable, and/or rotatable filter bodies at positions in the distributor channel. In some cases, the replaceable and/or rotatable filter bodies may be inserted into the distributor channel for 10 seconds to 30 minutes before being replaced. The filter bodies may be configured as an open-celled foam ceramic or a honeycomb body or a spaghetti filter and serve as a filter geometry of the replaceable and/or rotatable filter bodies in the distributor channel.

Abstract: New aluminum alloys having iron, vanadium, silicon, and copper, and with a high volume of ceramic phase therein are disclosed. The new products may include from 3 to 12 wt. % Fe, from 0.1 to 3 wt. % V, from 0.1 to 3 wt. % Si, from 1.0 to 6 wt. % Cu, from 1 to 30 vol. % ceramic phase, the balance being aluminum and impurities. The ceramic phase may be homogenously distributed within the alloy matrix.

Abstract: An object of the invention is to provide: a two-phase alloy as a metal material that can be preferably utilized under circumstances of a temperature range and a high corrosion as in an oil well, the two-phase alloy having a high corrosion resistance and good mechanical properties that are equivalent or more than those of conventional ones, and saving a cost; a product of the two-phase alloy; and a method for producing the product. There is provided a two-phase alloy containing Cr as a major component and including two phases of an austenite phase and a ferrite phase in a mixed state. The alloy has a chemical composition containing: 34-70 mass % of Cr; 17-45 mass % of Ni; 10-35 mass % of Fe; 0.1-2 mass % of Mn; 0.1-1 mass % of Si; and impurities. The total content of the Ni and the Fe is 30-65 mass %.

Abstract: A steel sheet for a crown cap having sufficient strength and formability suitable for forming crown caps even when reduced in gauge, and a method for producing the steel sheet for a crown cap. The steel sheet for a crown cap having a composition that includes, in terms of % by mass: C: 0.002% or more and 0.010% or less, Si: 0.05% or less, Mn: 0.05% or more and 0.30% or less, P: 0.030% or less, S: 0.020% or less, Al: less than 0.0100%, N: 0.0050% or less, and the balance being Fe and unavoidable impurities. The C content is more than 0.003% when the Al content is 0.005% or more. The yield strength in the rolling direction is 500 MPa or more. The average Lankford value is 1.3 or more.

Abstract: A thick-wall oil-well steel pipe has a wall thickness of 40 mm or more, excellent SSC resistance and high strength. The thick-wall oil-well steel pipe has a composition containing, in mass %, C: 0.40 to 0.65%, Si: 0.05 to 0.50%, Mn: 0.10 to 1.0%, P: 0.020% or less, S: 0.0020% or less, sol. Al: 0.005 to 0.10%, Cr more than 0.40 to 2.0%, Mo: more than 1.15 to 5.0%, Cu: 0.50% or less, Ni: 0.50% or less, N: 0.007% or less, and O: 0.005% or less. The number of carbide which has a circle equivalent diameter of 100 nm or more and contains 20 mass % or more of Mo is 2 or less per 100 mm2. The thick-wall oil-well steel pipe has yield strength of 827 MPa or more. A difference between a maximum value and a minimum value of the yield strength in the wall-thickness direction is 45 MPa or less.

Abstract: A rolled steel material for fracture splitting connecting rods consists of, C: 0.30 to 0.40%, Si: 0.60 to 1.00%, Mn: 0.50 to 1.00%, P: 0.04 to 0.07%, S: 0.04 to 0.13%, Cr: 0.10 to 0.30%, V: 0.05 to 0.14%, Ti: more than 0.15% to 0.20% or less, N: 0.002 to 0.020%, and optionally may contain Cu, Ni, Mo, Pb, Te, Ca, and Bi, with the balance being Fe and impurities. fn1, defined by Formula (1), ranges from 0.65 to 0.80. Relative to the V content in the steel material, a V content in coarse precipitates having a particle size of 200 nm or more is 70% or less, and relative to the Ti content in the steel material, a Ti content in the coarse precipitates is 50% or more.

Abstract: This disclosure describes new high temperature, radiation-resistant, ferritic-martensitic steel compositions. The new steels generally contain 9.0-12.0 wt. % Cr, 0.001-1.0 wt. % Mn, 0.001-2.0 wt. % Mo, 0.001-2.5 wt. % W, and 0.1-0.3 wt. % C, with the balance being primarily Fe. More specifically, steels having from 10.0-12.0 wt. % Cr are considered particularly advantageous. Small amounts of N, Nb, V, Ta, Ti, Zr, and B may or may not also be present, depending on the particular embodiment. Impurities may be present in any embodiment, in particular impurities of less than 0.01 wt. % S, less than 0.04 wt. % P, less than 0.04 wt. % Cu, less than 0.05 wt. % Co, and less than 0.03 wt. % As are contemplated. Examples of these steels exhibit improved fracture toughness and reduced thermal creep and swelling.

Abstract: The invention relates to a wrought product made of an aluminum alloy having the composition in % by weight, Mg: 4.0-5.0; Li: 1.0-1.8; Mn: 0.3-0.5; Zr: 0.05-0.15; Ag: ?0.5; Fe: ?0.1; Ti: <0.15; Si: ?0.05; other elements ?0.05 each and ?0.15 in association; the remainder is aluminum. The invention further relates to a method for manufacturing a wrought product wherein an unprocessed form of aluminum alloy is cast, which has the composition, in % by weight: Mg: 4.0-5.0; Li: 1.0-1.8; Mn: 0.3-0.5; Zr: 0.05-0.15; Ag: ?0.5; Fe: ?0.1; Ti: <0.15; Si: ?0.05; other elements ?0.05 each and ?0.15 in combination; the remainder is aluminum; optionally, said unprocessed form is homogenized; said unprocessed form is hot worked to obtain a hot-worked product; optionally, said hot-worked product is solution heat treated at a temperature from 360° C. to 460° C., preferably from 380° C. to 420° C.

Abstract: A casting mold material of the present invention includes, as a composition: 0.3 mass % to less than 0.5 mass % of Cr, 0.01 mass % to 0.15 mass % of Zr, and a balance consisting of Cu and inevitable impurities, and the casting mold material has acicular precipitates or plate-like precipitates containing Cr.

Abstract: An yttrium fluoride sprayed coating having a thickness of 10-500 ?m, an oxygen concentration of 1-6 wt %, and a hardness of 350-470 HV is deposited on a substrate surface. The yttrium fluoride sprayed coating exhibits excellent corrosion resistance in a halogen-base gas atmosphere or halogen-base gas plasma atmosphere, functions to protect the substrate from damage by acid penetration during acid cleaning, and minimizes particle generation from a reaction product and due to spall-off from the coating.

Abstract: A method of making a light weight component is provided. The method including the steps of: forming a metallic foam core into a desired configuration; and applying an external metallic shell to an exterior surface of the metallic foam core after it has been formed into the desired configuration.

Abstract: A vacuum evaporating source includes an evaporating material and a carbon nanotube composite membrane. The evaporating material is located on a carbon nanotube composite membrane surface. The carbon nanotube composite membrane includes a carbon nanotube film structure and a composite material layer, and the composite material layer is located on a surface of the carbon nanotube film structure surface.

Abstract: A vacuum evaporation apparatus includes an evaporating source belt, a depositing substrate, a vacuum room, a laser beam source, and a mesh in the vacuum room. The mesh includes a first surface and a second surface. The first surface faces and is spaced from the laser beam source. The second surface faces the depositing substrate. A portion of the evaporating source belt is located between the laser beam source and the mesh. The portion of the evaporating source belt between the laser beam source and the mesh is parallel to and spaced from the depositing substrate.

Abstract: The present invention relates to an improved composition for ion implantation. The composition comprises a dopant source and an assistant species wherein the assistant species in combination with the dopant gas produces a beam current of the desired dopant ion. The criteria for selecting the assistant species is based on the combination of the following properties: ionization energy, total ionization cross sections, bond dissociation energy to ionization energy ratio, and a certain composition.

Abstract: Disclosed are an apparatus for layer control-based synthesis and a method of using the same.

Abstract: A substrate processing apparatus includes: a substrate retainer configured to support a substrate; a heat-insulating unit; a transfer chamber; and a gas supply mechanism configured to supply a gas into the transfer chamber, the gas supply mechanism including: a first gas supply mechanism configured to supply the gas into an upper region of the transfer chamber, where the substrate retainer is disposed such that the gas flows horizontally through the upper region; and a second gas supply mechanism configured to supply the gas into a lower region of the transfer chamber, where the heat-insulating unit is provided such that the gas flows downward through the lower region, wherein the first gas supply mechanism and the second gas supply mechanism are disposed along a first sidewall of the transfer chamber, and the second gas supply mechanism is disposed lower than the first gas supply mechanism.

Abstract: A porous membrane material comprising a porous membrane substrate coated with a thin, uniform coating of a metal or metal alloy. The membrane material can have high electrical conductivity. The membrane material can exhibit a very high ratio of electrical conductivity to thermal conductivity. The porous membrane substrate may be removed to form the membrane.

Abstract: The invention relates to anti-multipactor coating deposited onto a substrate that can be exposed to the air and its procedure of obtainment by simple chemical methods. Furthermore, the present invention relates to its use for the fabrication of high power devices working at high frequencies.

Abstract: The present invention relates to a method for preventing the metallization of a support of at least one plastic part subjected to a metallization process, comprising the successive stages of oxidation of the surface of said part, of activation of the oxidized surface and of chemical and/or electrochemical deposition of metal on the activated surface, characterized in that it comprises a stage in which said support, before said oxidation stage, is brought into contact with an inhibiting solution comprising at least one specific metallization inhibitor. The invention also relates to a process for the selective metallization of a plastic part combined with a support, comprising bringing said part into contact with said inhibiting solution.

Abstract: A plating apparatus, a plating method and a recording medium can allow a temperature of a wafer to be uniform within a surface thereof. A plating apparatus 1 includes a substrate holding unit 52 configured to hold a substrate W; a plating liquid supply unit 53 configured to supply a plating liquid M1 to the substrate W; and a solvent supply unit 55a configured to supply a solvent N1 having a different temperature from a temperature of the plating liquid M1 to the substrate W. The solvent N1 is supplied to a preset position on the substrate W from the solvent supply unit 55a after the plating liquid M1 is supplied to the substrate W from the plating liquid supply unit 53.

Abstract: A method for making an environmentally-safe chromium based corrosion resistant coating includes pre-treating a metal substrate, immersing the metal substrate in a trivalent chromium bath which does not contain hexavalent chromium, post-treating the coated metal substrate with an oxidizer, and curing the coated metal substrate in a controlled environment.

Abstract: A method of making a light weight housing for an internal component is provided. The method including the steps of: forming a first metallic foam core into a desired configuration; forming a second metallic foam core into a desired configuration; inserting an internal component into the first metallic foam core; placing the second metallic foam adjacent to the first metallic core in order to secure the internal component between the first metallic foam core and the second metallic foam core; and applying an external metallic shell to an exterior surface of the first metallic foam core and the second metallic foam core.

Abstract: A method of making a light weight component is provided. The method including the steps of: forming a metallic foam core into a desired configuration; applying an external metallic shell to an exterior surface of the metallic foam core after it has been formed into the desired configuration; forming an inlet opening and an outlet opening in the external metallic shell in order to provide a fluid path through the metallic foam core; and injecting a thermoplastic material into the metallic foam core via the inlet opening.

Abstract: A process is provided for electrochemical reduction, particularly the electrochemical reduction of carbon dioxide to formate. According one embodiment, an electrochemical process includes the electrochemical reduction of carbon dioxide to formate utilizing periodic pulsed anodic polarization, periodic pulsed deep cathodic polarization, or combinations thereof to remove cathodic deposits. Various polarization techniques are disclosed which improve overall Faradaic Efficiency.

Abstract: A syngas generation system that combines a solid oxide electrolysis cell (SOEC) and a carbon gasification unit is described. On the cathode side of the SOEC, CO2 and H2O are electrochemically converted to syngas. At the anode side of the system, a second stream of syngas is produced through a carbon gasification process in which solid carbon is reacted with H2O/CO2. Oxygen ion transported across the SOEC electrolyte reacts at the anode with a portion of the syngas produced in the gasification process. This reaction product (H2O/CO2) can be fed back to the gasification unit.

Abstract: To provide an electrolysis cell for producing an organic chemical hydride capable of advancing a reduction reaction in a cathode of an organic compound having an unsaturated bond with high current efficiency and a small electric power consumption unit.

Abstract: The invention concerns a method for controlling at least one gas bubble produced in a localised manner in a medium (3?) allowing the movement of said at least one gas bubble, characterised in that it comprises a step consisting of generating at least one ultrasound burst towards said at least one gas bubble, said at least one burst being emitted for a burst duration at least partially covering a duration during which said gas is effectively being produced.

Abstract: The present invention provides a non-cyanide based Au—Sn alloy plating solution capable of performing a Au—Sn alloy plating treatment by a plating solution composition that is neutral and does not contain cyanide. In the present invention, a non-cyanide soluble gold salt, a Sn compound composed of tetravalent Sn, and a thiocarboxylic acid-based compound are contained. The non-cyanide based Au—Sn alloy plating solution of the present invention can further contain sugar alcohols, and, in addition, can further contain a dithioalkyl compound.

Abstract: A method of producing a die for forming an interior component of a vehicle includes: setting a temperature of a plating bath in a range from 25 to 40° C.; immersing at least a forming surface on a base for the die in the plating bath; and feeding a current to the base with a current density in a range from 20 to 80 A/dm2 until a metal layer is formed on the forming surface.

Abstract: Processes for enhancing the corrosion resistance of anodized substrates are disclosed. In some embodiments, the process involves a second anodizing operation that targets an area of the substrate that is left inadequately protected by a first anodizing operation, and also targets defects that may have been arisen from intermediate processing operations such as laser-marking operations. The second anodizing operation can be conducted in a non-pore-forming electrolyte, and grows a thick protective barrier film over inadequately protected areas of the substrate, such as laser-marking treated areas.

Abstract: A rotor for polishing hollow tubes, in which an outer tube is slidable over an inner tube and is provided with at least one window in the wall. At the window on the inner tube, a plate vane is fixed at the base end to an auxiliary shaft arranged perpendicular to the main shaft so as to be able to rotationally move. A link bar is arranged in the main shaft direction to extend between the outer tube and the plate vane. The rotor is able to transition between an initial state (plate vane closed) and an operational state (plate vane open) by the inner tube moving relative to the outer tube. An electrode for electropolishing or a buff for mechanical polishing is fixed to the tip end of the plate vane. This allows for adjustment of the position of the plate vane and control of the polished state.

Abstract: Spatial coordinates of multiple points on an inner surface of a vitreous silica crucible are measured prior to filling raw material in the vitreous silica crucible, and a three-dimensional shape of the inner surface of the vitreous silica crucible using a combination of polygons having vertex coordinates constituted by the respective measured points is specified (S11); a predictive value of an initial liquid surface level of the silicon melt in the vitreous silica crucible is preset (S12); a volume of the silicon melt satisfying the predictive value of the initial liquid surface level is obtained based on the three-dimensional shape of the inner surface of the vitreous silica crucible (S13); a weight of the silicon melt having the volume is obtained (S14); raw material having the weight is filled in the vitreous silica crucible (S15); a dipping control of the seed crystal is performed based on the predictive value of the initial liquid surface level (S17).

Abstract: A single crystal pulling apparatus including: a remelting detection apparatus which detects that remelting of a lower end portion of the semiconductor single crystal is completed from a change in weight of the semiconductor single crystal when the lower end portion of the semiconductor single crystal is immersed in the melt to be remolten by using the wire; and a lowermost end detection apparatus which detects a lowermost end of the semiconductor single crystal from a position where no current flows between the semiconductor single crystal and the melt when the semiconductor single crystal is taken up with the use of the wire while applying a voltage between the semiconductor single crystal and the melt by applying a voltage between the crucible and the wire.

Abstract: Methods for marking cellulosic products, including cellulosic fibers such as lyocell and cellulosic films, including methods for marking such products with a detectable nucleic acid marker to identify and validate the origin or authenticity of the products or items manufactured using such products. Detectably-marked cellulosic products marked with nucleic acid markers for authentication, validation and tracking are also provided.

Abstract: Disclosed is a lyocell crimped fiber manufactured by crimping a lyocell multi-filament. The lyocell multi-filament is manufactured by spinning a lyocell spinning dope containing a cellulose pulp and an N-methylmorpholine-N-oxide (NMMO) aqueous solution. The lyocell crimped fiber has a blooming index of 800 to 2,000.