Abstract: An improved oral administration coupler for delivery of fluids such as medications and nutritional fluids. Example oral administration couplers have a first end with an applicator for oral delivery to an infant, and a second end with a coupling compatible with an enteral fluid delivery syringe. A fluid delivery conduit extends in fluid communication from the first end to the second end, to deliver fluid from the syringe to the infant. In some example embodiments, the coupler is configured for back-of-mouth delivery, and can comprise a generally elongate and at least partially flexible tube or straw.

Abstract: The present invention discloses a medicine dispensing device for distributing medicine pills automatically, comprising a medicine supply system, a sorting system and a control system. The medicine supply system comprises a plurality of medicine supply units. The sorting system comprises a negative pressure medicine receiving mechanism, a camera subsystem, and two temporary storage cabins for medicine dispensing and discarding. The negative pressure medicine receiving mechanism has a negative pressure sucking head for sucking medicine pills. The negative pressure sucking head sucks a single medicine pill from a corresponding medicine supply unit. The camera subsystem captures images of medicine pills and sends the images to the control system. The camera subsystem recognizes the image of sucked medicine pill to identify the type, quantity and integrity of the medicine pill. This device fills the gap of no household automatic oral medicine dispensing device.

Abstract: There is provided an apparatus for monitoring compliance, facilitating automatic dispensing and childproofing strip packaged medication. In one embodiment a dispenser advances a packet, controls advancement of the packet and detects the presence and absence of the packet, including electronic circuitry for recording events. A replicate for strip package medication can have packets with an open conductive trace, each packet being rupturable at a location to interrupt conductivity of the conductive trace. When the conductive trace of one of the packets completes an external circuit, the circuit is interrupted when the packet is ruptured. In another aspect, each packet has a tuned antenna that is tuned to an external transceiver which detects the detuning of each antenna. In a method of making a replicate for strip package medication, conductive ink is printed on a surface of each packet of the replicate and longitudinal edges of the replicate are reinforced.

Abstract: An artificial nipple is formed of an elastomeric polymer by use of 3D printing after imaging of a mother's breast in an active state of lactation. The artificial nipple used as an attachment to a baby bottle or as the nipple component of a pacifier. Use of an artificial nipple formed in this manner mitigates a problem with nipple confusion, as may otherwise manifest in newborn offspring.

Abstract: An artificial nipple is formed of an elastomeric polymer by use of 3D printing after imaging of a mother's breast in an active state of lactation. The artificial nipple used as an attachment to a baby bottle or as the nipple component of a pacifier. Use of an artificial nipple formed in this manner mitigates a problem with nipple confusion, as may otherwise manifest in newborn offspring.

Abstract: An artificial nipple is formed of an elastomeric polymer by use of 3D printing after imaging of a mother's breast in an active state of lactation. The artificial nipple used as an attachment to a baby bottle or as the nipple component of a pacifier. Use of an artificial nipple formed in this manner mitigates a problem with nipple confusion, as may otherwise manifest in newborn offspring.

Abstract: Aid (1) for cup feeding of infants, which aid has a first liquid chamber and a second liquid chamber, wherein the first liquid chamber is provided for mounting on a feeding bottle (2), wherein the first liquid chamber (9) and the second liquid chamber (10) have a shared wall (12), wherein the second liquid chamber is open so that liquid in the second liquid chamber is accessible to an infant, whereby at least the shared wall is manufactured from an elastic material and is provided with an incision (13) with a minimum length of 3 mm such that a liquid flow through the incision from the first liquid chamber to the second liquid chamber is controllable by manipulating the wall.

Abstract: Cosmetic compositions and methods for changing the color of keratinic fibers are provided herein. In an embodiment, a cosmetic composition for lightening the color of keratinic fibers includes at least two separately packaged formulations (A) and (B), which are mixed immediately prior to application to give an application mixture. The formulation (A) includes at least one dye chosen from the group of oxidation dye precursors, direct dyes, or a combination thereof. The composition (B) is a flowable composition including water and at least one oxidizing agent. Formulation (A) has been packaged in a water-soluble film including, based on its total weight, at least about 60% by weight of a polymer mixture having a multimodal molecular weight distribution.

Abstract: A long lasting breath mint including a carrier and a flavorant, wherein the carrier includes at least one of a high viscosity cellulose ether and a low viscosity cellulose either and an alginate. The carrier forms a gel upon contact with saliva. A tablet is placed in the mouth of user, whereupon the tablet is wetted with saliva. A surface of the tablet is converted to a gel resulting in a tablet having an outer gel layer and a core. The gel serves as an adhesive for adhering the tablet to mouth structure. The gel slows exposure of the core to moisture and also slows diffusion of flavorant into the mouth of the user with the gel resulting in a breath mint having an extremely long life prior to complete dissolution, e.g., greater than 30 minutes or longer.

Abstract: A personal care composition is disclosed comprising abrasive particles. The personal care composition may take a variety of forms such as a leave-on composition or an emulsion and/or may comprise one or more actives or agents.

Abstract: The disclosure relates to a cosmetic product, comprising a) a cosmetic preparation, containing, in relation to its total weight, a1) about 45 to about 95 wt. % of at least one polar solvent; a2) about 0.1 to about 25 wt. % of at least one solid material; b) a device for flash evaporation of the cosmetic preparation a), and to a method using corresponding products and to the use of the cosmetic preparation a) as process material in a device for flash evaporation.

Abstract: The present invention relates to topical compositions in the form of an oil-in-water (O/W) emulsion comprising an oil phase dispersed in an aqueous phase in the presence of a polyglyceryl fatty ester surfactant, characterized in that the topical composition further comprises a phosphate ester co-surfactant. Furthermore, the invention relates to the use of a phosphate ester surfactant to reduce the viscosity of a topical composition in the form of an O/W emulsion comprising an oil phase dispersed in an aqueous phase in the presence of a polyglyceryl fatty ester surfactant.

Abstract: An encapsulated perfume composition in the form of a slurry comprising one or more core-shell capsules, dispersed in an aqueous dispersing medium, wherein the core contains a perfume and the shell contains a polyurea resin, and wherein the capsules are in the form of a stable suspension having a viscosity of up to 3000 centipoise, and more particularly about 150 to 3000 centipoise when measured on a rheometer, using rotating disks at a shear rate of 21 s?1 at a temperature of 25° C.

Abstract: The present invention provides an oral care composition comprising a peroxide compound and a zinc compound, wherein the weight ratio of the peroxide compound to the zinc compound is from 1:10 to 5:1.

Abstract: Provided is an oral care composition comprising a peroxide source, a polyhydric alcohol and a surfactant system having an HLB value of from 4 to 13, wherein the combined amount of the polyhydric alcohol and the surfactant system is from 60 weight % to 95 weight % by total weight of the composition, and wherein the weight ratio of the polyhydric alcohol to the surfactant system is from 9:1 to 1:4. The composition is resistant to peroxide decomposition.

Abstract: A porous silica particle optimized as the scrubbing agent is used for a cleansing cosmetic. The porous silica particle has an average circularity of 0.1 to 0.5, a pore volume of 1.0 to 2.0 ml/g, a mode diameter of 50 to 600 ?m, and a ratio of the maximum particle diameter to the mode diameter of 3.0 or less. The porous silica particle moreover has a median size of 0.5 to 25 ?m and the maximum particle diameter of 1 to 100 ?m, after rubbing with a load of 1.0 to 1.4 KPa for 30 seconds. With the cleansing cosmetic containing this particle, the skin is rubbed by the frictional force generated by the friction with the skin at the rubbing. Therefore, the mild peeling effect for the stratum corneum is obtained and the damage of the skin and the micro damage on the stratum corneum can be prevented.

Abstract: An anhydrous antiperspirant stick or soft solid composition comprising an antiperspirant active system, thickening agent, and non-aqueous carrier oil, characterised in that the particulate antiperspirant active system comprises an aluminium sesquichlorohyrate of formula AI2OH44CI1.6 to AI2OH4.9CI1.1 activated with a water soluble calcium salt.

Abstract: A multiple phase auto-warming composition free of water, preservatives and zeolites containing a least one visually distinct alkoxylated glycerin phase and at least one visually distinct oil phase; and a method for cleansing a keratin surface using the composition.

Abstract: A photostable UV-A/UV-B-sunscreen composition is provided. The composition includes an oil in water or water in oil emulsion, wherein the emulsion includes at least one photostabilizer having anti-oxidant properties, at least one SPF booster, and at least one UV-A filter and at least one UV-B filter. The UV-A/UV-B sunscreen composition is provided in which the composition is essentially free of oxybenzone.

Abstract: Provided is an agent for improving mitochondrial function including a hydroxycitric acid derivative represented by the following Formula (I) or a salt thereof, as an active ingredient [(In Formula (I), R1 and R2 each independently represent a hydrogen atom or any one group selected from the group represented by the following Formula (Ia) (here, R1 and R2 do not represent hydrogen atoms at the same time), X1 to X3 each independently represent a nitrogen or an oxygen atom, and R3, R4, R5, R3? R4?, and R5? each independently represent a hydrogen atom, or a chained hydrocarbon group (here, in a case where X1, X2, and X3 each independently represent an oxygen atom, corresponding R3?, R4?, or R5? does not exist). In Formula (Ia), R6 to R8 each independently represent a hydrogen atom, an aryl group, or a chained hydrocarbon group having 1 to 30 carbon atoms].

Abstract: The object of the present invention is to provide a photocurable composition for a topcoat of nails or artificial nails having excellent glossiness and a colorless and transparent outer appearance. The present invention is related to a photocurable composition for a topcoat of nails or artificial nails including the following components (A) to (C), including 40 to 70% by mass of trimethylol propane trimethacrylate relative to the total amount of the component (B), and satisfying that a cured product thereof with a thickness of 800 ?m has transmittance of 10.0% or higher at a wavelength of 400 nm: component (A); a (meth)acrylic oligomer; component (B): a trifunctional (meth)acrylic monomer contained at 50 to 100 parts by mass relative to 100 parts by mass of the component (A); and component (C): a photopolymerization initiator contained at 1 to 20 parts by mass relative to 100 parts by mass of the component (A).

Abstract: The present disclosure pertains to compositions that include the synergistic combination of cationic surfactants cetyl trimethyl ammonium chloride and quaternium-82, methods involving the application of such compounds to hair, methods for making hair conditioners using such compounds, and uses of compositions containing such compounds for conditioning of hair for reducing tangling, increasing the ease of combing, increasing softness, and increasing luster/shine.

Abstract: Compositions including a discontinuous oil phase homogeneously dispersed in a continuous water phase, the oil phase containing a sunscreen agent that includes a polymer composition containing a linear, ultraviolet radiation absorbing polyether, the linear, ultraviolet radiation absorbing polyether including a chemically bound UV-chromophore; and an oil-in water emulsifier component including an anionic oil-in-water emulsifier in an amount such that the composition includes about 0.5 percent by weight to about 3 percent by weight of the anionic oil-in-water emulsifier.

Abstract: The present application relates to antiperspirant compositions comprising nitrogen-based and/or oxygen based perfume raw materials, and methods for making and using the antiperspirant compositions.

Abstract: Disclosed is a compound of formula (I?): R?—O—CH2-CH(OH)—[CH2-O—CH2]s-[CH(OH)]p-CH2-O—R? (I?), formula (I?), wherein s is equal to 0 or 1, and p is equal to 0, 1, 2 or 3, R? and R?, identical or different, represent a hydrogen atom, or a monovalent radical of formula (II?a), or a monovalent radical of formula (II?b), in order to prevent or slow down the appearance of the signs of ageing of the human skin or lips or to eradicate these signs. Also disclosed are a novel product, novel composition and cosmetic method.

Abstract: The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one 6-substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs/cm2 and/or an increase the number of anagen hairs and maintain the number of telogen hairs when compared to a baseline and/or vehicle.

Abstract: The present invention provides a moisturizing agent including an inositol derivative as an active ingredient in which saccharide of three or more monosaccharide unit is bonded to per molecule of inositol.

Abstract: The present invention provides an agent for activating proliferation of follicle dermal papilla cells comprising an acidic saccharide alkaline earth metal salt, wherein the acidic saccharide is selected from the group consisting of a phosphorylated saccharide and lactobionic acid. The acidic saccharide is preferably a phosphorylated saccharide. The alkaline earth metal salt is preferably a calcium salt or a magnesium salt. In accordance with the present invention, the proliferation of follicle dermal papilla cells is promoted. Thus, the agent for activating proliferation of follicle dermal papilla cells is expected to produce hair-restoration and hair-growth effects such as treatment of hair thinning, prevention of hair loss, promotion of hair restoration, and promotion of hair growth.

Abstract: Cosmetic products and methods for the care of keratin-containing fibers using the cosmetic products are provided herein. In an embodiment, a cosmetic product includes a) a cosmetic preparation and b) a device for the flash evaporation of the cosmetic preparation a). The a cosmetic preparation a) includes, based on its total weight, a1) from about 70 to about 99% by weight of a polar solvent and a2) at least about 0.1% by weight of care components.

Abstract: The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.

Abstract: Disclosed is a new system for the application of mucoadhesive oral care compositions. The system comprises an applicator, the inner surface of which is made anti-adhesive. Particularly, said inner surface is rendered positively charged, so as to be anti-adhesive for positively charged mucoadhesive oral care compositions, such as those based on chitosan.

Abstract: A subject of the present invention is a composition comprising: a) at least one sebum-absorbing powder with a sebum uptake of greater than or equal to 35 ml/100 g, and/or at least one styling powder; b) at least one aluminium salt other than the sebum-absorbing powders with a sebum uptake of greater than or equal to 35 ml/100 g, and/or than the styling powders; c) optionally a propellant. A subject of the present invention is also to a process for the thy-washing and cosmetic treatment of keratin materials, comprising a step of applying the composition to the hair.

Abstract: Cationic and silicon substituents are introduced into polysaccharides thereby producing modified polysaccharides cationically substituted by quaternary ammonium groups and having a charge density of about 0.1 to about 2.5 meq/g, and further substituted by siliconate groups such that the modified polysaccharide has a silicon content of about 300 to about 5000 ppm. The modified polysaccharides have application in industrial, home care and personal care surface modifying formulations.

Abstract: The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.

Abstract: Certain dermatological formulations for direct skin application that correct for hyperpigmentation effects are provided. Such formulations include a number of different compounds that work synergistically to effectuate multiple and varied pathways to pigment removal and/or brightening within the dermal layer. The ability to do so without the necessity for hydroquinone, and thus with a suitable composition that is safe for handling and utilization by pregnant and nursing women, is accorded through a combination of specific ingredients in limited proportional ranges, as well. Such ingredients include kojic acid, niacinamide, sodium hyaluraonate, tocopherol, and licorice extract in very narrow ranges proportionally within an aqueous serum. The method of manufacture and use thereof such formulations are encompassed within the invention as well.

Abstract: Disclosed are a cosmetic composition for improving anti-oxidation, anti-inflammation and atopic skin by using fermented liquid of black tea as an effective ingredient and a method of preparing the same. The cosmetic composition includes the fermented black tea liquid obtained by primarily fermenting black tea with saccharomyces, secondarily fermenting the black tea with gluconacetobacter and tertiarily fermenting the black tea with bacillus.

Abstract: The present invention provides an inhalation-type pharmaceutical composition for gout and preparation method thereof, comprising a first gas and an atomized medicine. The first gas comprises hydrogen. The gas volume concentration of hydrogen in the inhalation-type pharmaceutical composition is between 2 to 96%. The atomized medicine is selected from a group comprising colchicine, allopurinol, probenecid, sulfinpyrazone, and any combination thereof. The inhalation-type pharmaceutical composition of the present invention can remove harmful radicals in the body of the patient through the use of hydrogen while also increases the absorption effect of the medicine for the patient by using an atomized medicine. At the same time, because the use of the small amount of the vaporized pharmaceutical liquid can indirectly reduce the side effects on the user.

Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.

Abstract: The invention is related to an improved method of contraception, for preventing or suppressing abnormal and/or irregular endometrial bleeding and achieving a rapid induction of amenorrhea by using an intrauterine delivery system comprising controlled release levonorgestrel over a prolonged period of time and at a therapeutic level required for contraception, and a sufficient amount of NSAID capable of suppressing abnormal and/or irregular endometrial bleeding

Abstract: A method applying a pharmaceutical composition as a foam is disclosed. The pharmaceutical composition includes a quick-break foaming agent including an aliphatic alcohol, water, a fatty alcohol and a surface active agent; a buffering agent; and a propellant. The method includes spraying the composition from a pressurizable container that comprises an aerosol valve assembly including a dip tube communicating with a valve orifice through which the composition is dispensed and an actuator to start and stop dispensation.

Abstract: Thus, the present invention provides a composition in powder form comprising highly dispersed silica particles, polymethylsiloxane particles, and a cationic surfactant, wherein at least 25% by weight of the cationic surfactant is present in primary polymethylsiloxane particles carrying the cationic surfactant on their surface and/or in agglomerates of these primary particles.

Abstract: Disclosed are taste-masked pharmaceutical formulations of raltegravir comprising coated API granules mixed with a screened powder excipient blend in either tablet or sachet form. The core and coated granules are produced using a Wurster process for enhanced control of particle size. Also disclosed are methods of treating HIV, e.g., in pediatric populations.

Abstract: The present invention relates to a sprinkle composition of cinacalcet which provides a dissolution profile which is comparable to the currently marketed tablet dosage form.

Abstract: The present invention relates to a pharmaceutical formulation comprising an immediate release phase comprising an effective amount of flurbiprofen and a controlled release phase comprising an effective amount of tramadol and pharmaceutically acceptable excipients.

Abstract: The present invention relates to improved uses of GLP-1 peptides in oral therapy.

Abstract: This invention relates to pharmaceutical dosage forms for delivery of drugs susceptible to abuse, such as, for example, oxycodone and/or oxymorphone.

Abstract: A comestible dosage form article for administration to a target subject, the dosage form comprising: an outer capsule comprising a first cap telescopically engageable with a first body; and an inner capsule, within the outer capsule, comprising a second cap telescopically engageable with a second body, wherein the inner capsule is inverted with respect to the outer capsule such that, in an assembled state, the second cap is proximal to the first body and distal to the first cap.

Abstract: A dosage form article consisting of a hard capsule coated with a surface modifying coating wherein the coating is an aqueous composition comprising water and a muco-adhesive polymer selected from the group consisting of poly(acrylates), cellulose derivatives, hyaluronic acid, starch, poly(ethylene glycol), polysaccharides, collagen derivatives, and mixtures thereof, wherein the ratio of the muco-adhesive polymer to water is less than 0.15 by weight of the coating composition.

Abstract: The present invention is directed to a process for the preparation of enteric microparticles comprising nanoparticles, wherein the nanoparticles comprise a matrix and an active ingredient. The microparticles obtained by such process are usable various multiparticulate pharmaceutical formulations such as extemporaneous dosage forms (powder for reconstitution).

Abstract: The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.