Patents Issued in November 2, 2017
  • METHOTREXATE FORMULATION
    Publication number: 20170312281
    Abstract: A liquid pharmaceutical composition comprises methotrexate free acid and a buffer, wherein the pH of the composition is in the range of 6.5 to 8.2. Processes for preparation of the liquid pharmaceutical composition are also described. The liquid pharmaceutical composition is useful in therapy.
    Type: Application
    Filed: October 28, 2015
    Publication date: November 2, 2017
    Applicant: Therakind Ltd.
    Inventors: Michael FRODSHAM, Julie-Ann PENTON
  • TYROSINE KINASE INHIBITOR FORMULATIONS FOR THE TREATMENT OF MAST CELL-MEDIATED INFLAMMATORY DISEASES AND METHODS OF USE THEREOF
    Publication number: 20170312282
    Abstract: Methods of treating mast cell-mediated inflammatory diseases are provided by local administration a therapeutically effective amount of a tyrosine kinase inhibitor to a patient in need thereof.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Inventors: William H. Robinson, Anna Postolova, Harini Raghu
  • ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS
    Publication number: 20170312283
    Abstract: Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV in an infected patient.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 2, 2017
    Inventors: Christina Gavegnano, Raymond F. Schinazi
  • ANALOGS OF ADENOSINE MONOPHOSPHATE (AMP) AS INHIBITORS OF UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
    Publication number: 20170312284
    Abstract: Disclosed are analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activing enzyme ATG7. The AMP analogs may be formulated as pharmaceutical compositions for treating diseases or disorders that depend on ATG7 activity and/or autophagy such as cell proliferative diseases and disorders.
    Type: Application
    Filed: May 2, 2017
    Publication date: November 2, 2017
    Applicant: Northwestern University
    Inventors: Alexander V. Statsyuk, Heeseon An
  • COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY
    Publication number: 20170312285
    Abstract: The present invention relates to a compound of formula (I), provided that this compound is not caffeine, for use in the treatment of myotonic dystrophy type 1 and type 2. The present invention also relates to compositions comprising the compound of formula (I). The present invention further relates to new compounds which are dimers of compounds of formula (I).
    Type: Application
    Filed: November 13, 2015
    Publication date: November 2, 2017
    Inventors: Ruben ARTERO ALLEPUZ, Josep CASTELLS BOLIART, José Ignacio BORRELL BILBAO, Beatriz LLAMUSI TROÍSI, Ariadna BARGIELA SCHÖNBRUNN, Piotr KONIECZNY, Marta PASCUAL GILABERT, Jordi TEIXIDÓ CLOSA, Roger ESTRADA TEJEDOR, Alejandro LÓPEZ GONZÁLEZ
  • COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER
    Publication number: 20170312286
    Abstract: A method for inhibiting a lipid metabolism disorder of a warm-blooded animal includes administering a therapeutically effective amount of a compound being one selected from the group consisting of phosphodiesterase 5 (PDE-5) inhibitors of the first type and second type and a Statin analogue to a warm-blooded animal suffering from the lipid metabolism disorder. The method may treat the disease selected from the group consisting of liver disease, non-alcoholic fatty liver disease, hyperadiposity, dyslipidemia, hepatic steaotosis, high-fat-diet-induced lipid accumulation, high-fat-diet-induced obesity, insulin resistance, high-fat-diet-induced lipid accumulation combined with a symptom of one of inflammation and liver damage, and any combination thereof.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Inventor: Ing-Jun Chen
  • DPP IV INHIBITOR FORMULATIONS
    Publication number: 20170312287
    Abstract: The present invention relates to pharmaceutical compositions of DPP IV inhibitors with an amino group, their preparation and their use to treat diabetes mellitus.
    Type: Application
    Filed: July 20, 2017
    Publication date: November 2, 2017
    Inventors: Anja KOHLRAUSCH, Patrick ROMER, Gerd SEIFFERT
  • TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS
    Publication number: 20170312288
    Abstract: The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Applicant: Strategic Science & Technologies, LLC
    Inventor: Eric T. Fossel
  • METHODS, SYSTEM, AND KIT FOR MONITORING, DIAGNOSING, AND TREATING IMPULSIVE AGGRESSION
    Publication number: 20170312289
    Abstract: The present disclosure relates to the treatment of impulsive aggression with molindone as an add-on therapy where patients are already receiving treatment for the underlying disease or disorder, e.g. attention deficit hyperactivity disorder (ADHD), bipolar disorder, autism, Tourette's syndrome or post traumatic stress disorder (PTSD), using evidence-based impulsive aggression testing methodologies and systems.
    Type: Application
    Filed: April 27, 2017
    Publication date: November 2, 2017
    Applicant: Supernus Pharmaceuticals, Inc.
    Inventors: Jennifer DUGAN STOCKS, Christopher EVANS, Seung HWANG, Susan M. DALLABRIDA
  • FUNCTIONALIZED MORPHOLINYL ANTHRACYCLINE DERIVATIVES
    Publication number: 20170312290
    Abstract: The present invention relates to new functionalized morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds, or the pharmaceutical compositions containing them. The invention also relates to the use of these derivatives in the preparation of conjugates.
    Type: Application
    Filed: November 4, 2015
    Publication date: November 2, 2017
    Inventors: Italo Beria, Michele Caruso, Vittoria Lupi
  • METHOD OF TREATING MICROBIAL INFECTIONS
    Publication number: 20170312291
    Abstract: The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
    Type: Application
    Filed: April 10, 2017
    Publication date: November 2, 2017
    Inventors: Richard L. Gallo, Teruaki Nakatsuji
  • THERAPEUTIC COMPOUNDS AND USES THEREOF
    Publication number: 20170312292
    Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
    Type: Application
    Filed: April 7, 2017
    Publication date: November 2, 2017
    Inventors: Anthony F. Romero, Steven R. Magnuson, Richard Pastor, Vickie Hsiao-Wei Tsui, Jeremy Murray, Terry Crawford, Daniel J. Burdick, Brian K. Albrecht, Alexandre Cote, Alexander M. Taylor, Christopher G. Nasveschuck, Yves LeBlanc, Michael Charles Hewitt, Kwong Wah Lai, Kevin Chen
  • ANTIMICROBIAL WATER DISPERSIBLE COMPOSITION COMPRISING ZINC PYRITHIONE
    Publication number: 20170312293
    Abstract: Disclosed is an antibiotic aqueous dispersion composition including as an active ingredient zinc pyrithione and, at least one subsidiary antiseptic selected from the group consisting of thiamine dilauryl sulphate (TDS), a salt and glyceryl monoalkyl ether. The composition has excellent stability and wide antibiotic or antiseptic spectra to bacteria and fungus.
    Type: Application
    Filed: November 13, 2015
    Publication date: November 2, 2017
    Applicant: KOLON LIFE SCIENCE, INC.
    Inventors: Ji Hye LEE, Yong Suk JEON, Hee Won CHO, Ki Hoon YANG, Hye Ji YOON
  • COMBINATION OF LUPEOL ACETATE AND CURCUMIN USED FOR THE TREATMENT OR PREVENTION OF OSTEOPOROSIS
    Publication number: 20170312294
    Abstract: The present invention relates to synergistic combinations of lupeol acetate and curcumin at low dosage, and their use for the treatment or prevention of osteoporosis.
    Type: Application
    Filed: July 14, 2017
    Publication date: November 2, 2017
    Inventors: Jeng-Jong HWANG, Wei-Hsun WANG
  • Ophthalmologic Irrigation Solutions and Method
    Publication number: 20170312295
    Abstract: Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein the multiple agents are selected to target multiple molecular targets to achieve multiple differing physiologic functions, and are included in dilute concentrations in a balanced salt solution carrier.
    Type: Application
    Filed: January 25, 2017
    Publication date: November 2, 2017
    Inventors: Gregory A. Demopulos, Pamela Pierce Palmer, Jeffrey M. Herz
  • AGENTS FOR KILLING HIV-1-INFECTED CELLS AND APPLICATION THEREOF
    Publication number: 20170312296
    Abstract: The present invention relates to an agent for killing HIV-1-infected cells, comprising a compound represented by formula (I): wherein Ar1 and Ar2 are the same or different and represent a substituted or unsubstituted aromatic group, and X represents —CH2O— or —CH?CH—, its salt, or their solvate, and a combined preparation for simultaneous, separate, or sequential administration in treating or preventing HIV-1 infection, comprising two separate preparations: (a) a preparation comprising a compound represented by the formula (I), its salt, or their solvate, and (b) a preparation comprising an anti-HIV-1 drug.
    Type: Application
    Filed: July 17, 2017
    Publication date: November 2, 2017
    Inventor: Mika OKAMOTO
  • Long Acting Pharmaceutical Compositions For Hepatitis C
    Publication number: 20170312297
    Abstract: The present Invention relates to long acting pharmaceutical compositions useful in the treatment or prevention or cure of viral infections, such as HCV infections, and diseases associated with such infections.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 2, 2017
    Applicant: Glaxosmithkline Intellectual Property (NO. 2) Limited
    Inventors: Zhi HONG, Martin R. LEIVERS
  • MIXTURES OF HMOs
    Publication number: 20170312298
    Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2?-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2?-FL, and a component D, which is lactose when component A is 3-FL, or 2?-FL when component A is DFL, with the proviso that if component B is 2?-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.
    Type: Application
    Filed: October 23, 2015
    Publication date: November 2, 2017
    Inventors: Elise CHAMPION, Bruce MCCONNELL, Gyula DEKANY
  • Cellular Delivery of DNA Intercalating Agents
    Publication number: 20170312299
    Abstract: Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.
    Type: Application
    Filed: June 23, 2017
    Publication date: November 2, 2017
    Inventors: Robert C. Getts, James Kadushin, Mindy George-Weinstein, Jacquelyn Gerhart, Emanuela Dylgjeri, Kelly Rhodes
  • Methods for Treating Cancer
    Publication number: 20170312300
    Abstract: The invention relates to nicotinamide riboside or a derivative thereof for use in the treatment and/or prevention of liver or pancreatic cancer in a subject. Additionally, the invention relates to an in vitro method for designing a customized therapy for a subject diagnosed with a liver cancer or pancreatic cancer or suffering early signs of chronic liver damage or pancreatic intraepithelial lesions based on determining the level of DNA damage. Additionally the invention also relates to a method for diagnosing liver cancer and for predicting the risk of developing liver cancer in a subject suffering hepatitis. The invention also relates to a kit and their use in the methods of the invention.
    Type: Application
    Filed: July 30, 2015
    Publication date: November 2, 2017
    Applicant: Fundacion Centro National de Investigaciones Oncolgicas Carlos III
    Inventors: Nabil Djouder, Krishna Seshu Tummala
  • SKIN BARRIER FUNCTION-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN BARRIER FUNCTION
    Publication number: 20170312301
    Abstract: The present invention provides a skin barrier function-improving agent including an inositol derivative as an active ingredient in which inositol and saccharide are bonded, and a composition for improving a skin barrier function including the above skin barrier function-improving agent and a pharmacologically acceptable carrier.
    Type: Application
    Filed: July 23, 2015
    Publication date: November 2, 2017
    Applicant: SHOWA DENKO K.K.
    Inventors: Yuko SAEKI, Eiko KATO
  • PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20170312302
    Abstract: Phosphoramidate derivates of 5-fluoro-2?-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.
    Type: Application
    Filed: April 18, 2017
    Publication date: November 2, 2017
    Inventors: Christopher McGuigan, Jan Balzarini, Magdalena Slusarczyk, Blanka Gonczy, Paola Murziani
  • COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF
    Publication number: 20170312303
    Abstract: In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
    Type: Application
    Filed: March 31, 2015
    Publication date: November 2, 2017
    Inventors: Barton F. HAYNES, Beatrice H. HAHN, George M. SHAW, Bette T. KORBER, Peter T. HRABER
  • miRNA FOR TREATING CANCER AND FOR USE WITH ADOPTIVE IMMUNOTHERAPIES
    Publication number: 20170312304
    Abstract: In some aspects, miRNA for the treatment of cancer are provided. In some embodiments, a miRNA (e.g., miR-124, miR-142, and/or miR-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject. In other aspects, the miRNA may be used in, or in combination with, an adoptive immunotherapy.
    Type: Application
    Filed: May 9, 2017
    Publication date: November 2, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Amy HEIMBERGER, Jun WEI
  • PHARMACEUTICAL EXTRACTS AND USES THEREOF
    Publication number: 20170312305
    Abstract: The invention provides an isolated extract comprising glycosaminoglycans from whelk and/or cockle species.
    Type: Application
    Filed: October 26, 2015
    Publication date: November 2, 2017
    Applicant: UNIVERSITY OF SALFORD ENTERPRISES LIMITED
    Inventors: David Alexander PYE, Olanrewaju Dorcas OGUNDIPE
  • SHEAR-THINNING HYDROGEL, KIT AND METHOD OF PREPARATION
    Publication number: 20170312306
    Abstract: A shear-thinning hydrogel composition includes: a first polymer chain including: (i) a first plurality of units each having at least one of a monosaccharide and an amino acid; and (ii) a cross-linking group bound to the at least one of the monosaccharide and the amino acid of one of the first plurality of units via conversion of a carboxyl group of the unit to a peptide bond; a second polymer chain including a second plurality of the units; and a cross-linking additive connecting one of the second plurality of units to the first polymer chain via the cross-linking group.
    Type: Application
    Filed: June 29, 2017
    Publication date: November 2, 2017
    Inventors: Duleeka Nimantha Bandara RANATUNGA, Andrew Christopher WENGER, Zhi Yuan (William) LIN
  • TOPICAL GELS AND METHODS OF USING THE SAME
    Publication number: 20170312307
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • XENON AND/OR ARGON TREATMENT AS AN ADJUNCT TO PSYCHOTHERAPY FOR PSYCHIATRIC DISORDERS
    Publication number: 20170312308
    Abstract: The present invention relates generally to the fields of treating psychiatric disorders, in particular, anxiety disorders including post-traumatic stress disorder (PTSD) in subjects, e.g., human subjects, by administering a xenon and/or argon containing composition. Treatments can also employ psychotherapy in combination with administration of xenon and/or argon, alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce a symptom of the anxiety disorder in the subject.
    Type: Application
    Filed: July 19, 2017
    Publication date: November 2, 2017
    Applicant: THE MCLEAN HOSPITAL CORPORATION
    Inventors: Edward G. Meloni, Marc J. Kaufman
  • INTRADIALYTIC ADMINISTRATION OF SODIUM THIOSULFATE
    Publication number: 20170312309
    Abstract: The invention provides a source of sodium thiosulfate via the dialysate used to cleanse the bool of toxic and metabolic waste in the patients undergoing hemodialysis, peritoneal dialysis, or gastro-intestinal dialysis for treatment of end-stage or near end-stage chronic renal disease. In the method of the invention, dialysis solution components contain therapeutic amounts of sodium thiosulfate, which when fully reconstituted for use as a single solution, deliver 20-130 mg/dl of dialysate.
    Type: Application
    Filed: July 17, 2017
    Publication date: November 2, 2017
    Inventor: Anupkumar Shetty
  • USE OF NITRITE SALTS IN CHRONIC ISCHEMIA
    Publication number: 20170312310
    Abstract: Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.
    Type: Application
    Filed: April 10, 2017
    Publication date: November 2, 2017
    Inventors: Christopher Kevil, David Lefer, Rakesh Patel
  • COMPOSITION, CONTAINING HIGH-HARDNESS MINERAL WATER PREPARED FROM SALTY UNDERGROUND WATER OR DEEP-SEA WATER, FOR PREVENTING OR ALLEVIATING DECREASE IN BLOOD PRESSURE OR SYMPTOMS RELATED THERETO
    Publication number: 20170312311
    Abstract: The present invention relates to a composition, containing, as an active ingredient, high-hardness mineral water prepared from salty underground water or deep-sea water, for preventing or alleviating a decrease in blood pressure or symptoms related thereto. According to the present invention, the high-hardness mineral water prepared from salty underground water or deep-sea water, especially, prevents a rapid decrease in blood pressure or mitigates the degree of decrease in blood pressure, during or after exercise, and thus can be used to prevent or alleviate symptoms related to a rapid decrease in blood pressure during or after exercise.
    Type: Application
    Filed: October 29, 2015
    Publication date: November 2, 2017
    Inventors: Jai Jun CHOUNG, Soo Hyun SUNG, Jong Kyu KIM, Chang Ho SHIN
  • Chlorite-Containing Compositions
    Publication number: 20170312312
    Abstract: A method for treating or preventing one of a fungal infection of a nail and a condition of a skin surface excluding an oral cavity. The method includes the step of applying a composition to one of a nail surface adjacent to the infection of the nail and the skin surface having the condition. The composition comprises a plant-based bioactive and between about 0.2% to about 3.0% by weight of a metal chlorite salt. The composition does not contain a therapeutically effective amount of chlorine dioxide.
    Type: Application
    Filed: July 17, 2017
    Publication date: November 2, 2017
    Inventor: Karen C. Swenholt
  • SYNTHESIS OF ULTRA-SMALL CERIA-ZIRCONIA NANOPARTICLES AND CERIA-ZIRCONIA NANO COMPLEX AND ITS APPLICATION AS A THERAPEUTIC AGENT FOR SEPSIS
    Publication number: 20170312313
    Abstract: Disclosed is a ceria-zirconia nanoparticles comprising a core layer consisting of particles made of ceria-zirconia; and a surfactant layer formed by binding a surfactant on the surface of the core layer so as to easily react in vivo, and more particularly, to applying a ceria-zirconia nano complex to an application field as an activator and a sepsis treating agent.
    Type: Application
    Filed: May 4, 2016
    Publication date: November 2, 2017
    Applicants: Seoul National University R&DB Foundation, INSTITUTE FOR BASIC SCIENCE
    Inventors: Taeg Hwan HYEON, Seung Hoon LEE, Min SOH, Chi Kyung KIM
  • SYSTEM FOR TREATING A SEBACEOUS GLAND
    Publication number: 20170312314
    Abstract: One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the composition is applied; means to selectively remove at least some of the composition from the skin surface after application of the means to vibrate, while leaving the metallic nanoparticles in proximity to or within the sebaceous gland; and means to optically irradiate the skin to which the composition was applied with light energy after removal of at least some of the composition from the skin surface.
    Type: Application
    Filed: July 12, 2017
    Publication date: November 2, 2017
    Applicant: The General Hospital Corporation
    Inventors: Richard Rox Anderson, William A. Farinelli, Gerard van Hamel Platerink
  • Engineered Dendritic Cells and Uses for the Treatment of Cancer
    Publication number: 20170312315
    Abstract: This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL-12) under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals including human.
    Type: Application
    Filed: May 10, 2017
    Publication date: November 2, 2017
    Applicants: Intrexon Corporation, University of Pittsburgh-Of The Commonwealth System Of Higher Education
    Inventors: Mark BRAUGHLER, Prasanna Kumar, Walter J. Storkus, Hideho Okada
  • CARTILAGE CELLS WITH A HIGH REGENERATIVE POTENTIAL AND LOW IMMUNE RESPONSE FOR USE IN CELLULAR THERAPY
    Publication number: 20170312316
    Abstract: Cell-based therapies for cartilage repair and regeneration selectively using chondrocytes carrying a CD24 surface marker are disclosed. In particular, chondrocytes carrying the CD24 surface marker have a high regenerative potential and low responsiveness to inflammatory cues. Since cartilage injuries as well as chronic cartilage degenerative conditions are often accompanied by a heightened inflammatory environment, cartilage cell populations carrying the CD24 surface marker, which are resistant to the inflammatory environment, provide more efficient cartilage repair. Thus, chondrocytes carrying the CD24 surface marker are useful in cell-based therapies for regenerating or repairing cartilage.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Inventors: Nidhi Bhutani, Jieun Lee, Sarah Taylor
  • CELL-BASED THERAPY FOR THE PULMONARY SYSTEM
    Publication number: 20170312317
    Abstract: Cell based therapy comprises administration to the lung by injection into the blood system of viable, mammalian cells effective for alleviating or inhibiting pulmonary disorders. The cells may express a therapeutic transgene or the cells may be therapeutic in their own right by inducing regenerative effects.
    Type: Application
    Filed: February 27, 2017
    Publication date: November 2, 2017
    Applicant: Northern Therapeutics Inc.
    Inventor: Duncan John Stewart
  • METHODS AND COMPOSITIONS FOR IN VIVO INDUCTION OF PANCREATIC BETA CELL FORMATION
    Publication number: 20170312318
    Abstract: Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes. In certain aspects, the methods include the integration of three levels of cellular physiology: metabolism, membrane receptor function, and gene transcription. The integration of multiple levels of cellular physiology produces a synergistic effect on beta cell formation.
    Type: Application
    Filed: May 15, 2017
    Publication date: November 2, 2017
    Inventors: Bruno DOIRON, Ralph A. DEFRANZO
  • PERICYTES ARE INTERMEDIATE PROGENITORS FOR EPICARDIAL DERIVED CORONARY ARTERY SMOOTH MUSCLE
    Publication number: 20170312319
    Abstract: Methods and compositions are provided for regenerating smooth muscle tissue by the provision of a purified population of epicardial-derived pericytes, where the smooth muscle tissue may comprise, without limitation, coronary artery tissue; kidney tissue, etc. Compositions and kits for practicing the methods and/or for use with the systems of the disclosure are also provided.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Inventors: Kristy Red-Horse, Katharina Volz, Irving L. Weissman
  • BACTERIA ENGINEERED TO REDUCE HYPERPHENYLALANINEMIA
    Publication number: 20170312320
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 2, 2017
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Sarah Rowe, Yves Millet
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS
    Publication number: 20170312321
    Abstract: The invention relates to products and compositions that may be beneficial in animal husbandry. Said products and compositions comprise microorganisms, such as bacteria, and probiotic bacteria in particular. Thus, provided herein are microbial strains, as well as selection criteria which will enable the skilled reader to find further strains useful in the present invention. The strains, as well as compositions comprising the same, may be administered to animals, farmed animals such as swine in particular. The administration may occur in the first days of life. By administration of the products or compositions of the inventions animal growth can. be promoted and animal weight can be increased. Infections may also be prevented or treated by said compounds or compositions.
    Type: Application
    Filed: October 21, 2015
    Publication date: November 2, 2017
    Inventors: Pedro Miguel Rubio Nistal, Ana Maria Carvajal Urueña, Marta García Díez
  • ANTIBACTERIAL AND PROTECTIVE FORMULATIONS AND METHODS FOR MAKING AND USING THEM
    Publication number: 20170312322
    Abstract: Provided are compositions and methods for treating, ameliorating and preventing various infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor, where exemplary compositions are products of manufacture, a food, a drink, a nutraceutical, a dietary supplement, a formulation, a pharmaceutical or a pharmaceutical preparation comprising at least one or several of a plurality of isolated, or substantially purified bacteriophages or prophages, or bacteriophage subunits, a milk, a milk product, milk lipid, C milk fat globule (MFG) macromolecule, a milk mucin, a milk glycolipid, a milk free glycan, a milk mucin-like glycoprotein, a milk protein, a milk sugar or lactose, a milk fat or butterfat, a milk vitamin.
    Type: Application
    Filed: November 18, 2015
    Publication date: November 2, 2017
    Inventors: Forest ROHWER, Jeremy J. BARR, J. Bruce GERMAN
  • GEL CAPSULE COMPRISING A PLANT CELL
    Publication number: 20170312323
    Abstract: Disclosed is a capsule including: an internal phase including at least one plant cell; and an external gel phase, that totally encapsulates the internal phase at its periphery, the external phase including at least one surfactant and at least one polyelectrolyte in the gel state.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 2, 2017
    Inventors: Edouard DULIEGE, Thomas DELMAS, Sebastien BARDON, Jerome BIBETTE, Nicolas BREMOND, Hugo DOMEJEAN
  • USE OF MAITAKE AND MAITAKE GRIFOLAN D COMPONENT IN PREPARATION OF ANTIDEPRESSANT DRUG
    Publication number: 20170312324
    Abstract: The present invention “use of Maitake and Maitake polysaccharide D Fraction in manufacture of medicaments for anti-depression” belongs to the field of pharmaceuticals, which characterized in that the Maitake whole herb, Maitake extract or Maitake polysaccharide D fraction is used in the preparation of antidepressants. The medicament can be used to treat or prevent depression, which has a significant antidepressant effect, not only strong effect, but also no conventional antidepressant medicaments toxicity, side effects, such as induced epilepsy, ataxia and other shortcomings. Therefore, they can be used as an excellent antidepressant candidate medicament.
    Type: Application
    Filed: October 28, 2015
    Publication date: November 2, 2017
    Applicant: Yunnan University
    Inventors: Jing DU, Chunjie XIAO, Hongkun BAO, Ming ZHU
  • SEXUAL FUNCTION IMPROVING COMPOSITION CONTAINING AS ACTIVE INGREDIENT EXOPOLYSACCHARIDE PRODUCED BY MEANS OF CERIPORIA LACERATA
    Publication number: 20170312325
    Abstract: The present invention relates to a sexual function improving composition containing as an active ingredient: exopolysaccharide produced by means of Ceriporia lacerata; a Ceriporia lacerata mycelium culture medium comprising the exopolysaccharide; dry powder of the mycelium culture medium; or an extract of the mycelium culture medium. The composition can be used as a sexual function improving drug for preventing or treating erectile dysfunction or diabetic erectile dysfunction or as a functional health food having sexual function improving effect.
    Type: Application
    Filed: November 3, 2015
    Publication date: November 2, 2017
    Applicant: FUGENBIO CO., LTD.
    Inventor: Yoon Soo KIM
  • Smokeless cannabis composition and method of manufacture
    Publication number: 20170312326
    Abstract: A cannabis composition includes a cannabis material and an additive solution. Cannabis material includes flowers, sugar leaves, and fan leaves from a cannabis plant, and can be configured to be finely cut or coarsely cut. An additive solution includes honey and a cannabis extract. Further disclosed is a method of manufacture of a cannabis composition, including a method for allowing a cannabis composition to ferment and a method of heating a cannabis composition.
    Type: Application
    Filed: July 25, 2016
    Publication date: November 2, 2017
    Inventor: Mark J. Silen
  • EXTRACTION DEVICES, SYSTEMS, AND METHODS
    Publication number: 20170312327
    Abstract: An extraction device that can include a first solvent chamber, an extraction chamber, a collection chamber and a second solvent chamber. The various chambers of the extraction device are connected in fluid communication with one or more chambers of the device through one or more connectors. A connector can include one or more flow control elements that control flow of fluid from one chamber to one or more other connected chambers. Additionally, the various chambers of the extraction device can be arranged in multiple configurations and connections between the chambers.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventor: Andrew Jones
  • NUTRITIONAL SUPPLEMENTS FOR IMPROVING MALE FERTILITY
    Publication number: 20170312328
    Abstract: The present invention relates to a fertility-enhancing composition for human male fertility therapy and a method for using the same to improve or enhance human male fertility. The nutritional supplement composition of the invention includes an effective amount of L-carnitine, coenzyme Q10, vitamin B12, N-acetyl L-cysteine, and grape seed extract.
    Type: Application
    Filed: April 30, 2016
    Publication date: November 2, 2017
    Applicant: Fairhaven Health, LLC
    Inventor: Suzanne Munson
  • Compositions and Methods for Treatment of Prediabetes
    Publication number: 20170312329
    Abstract: The invention provides compositions and methods to treat prediabetes. In particular, the inventor has discovered that particular combinations of diverse types of antioxidants have synergistic and surprising effects for use against prediabetes. The composition includes: a plurality of heteroatom-based antioxidants having the formula X—CH2—CH(R)—(CH2)m—Z; a plurality of antioxidants with a conjugated segment; an antioxidant that is a flavan-3-ol; and an antioxidant that contains a disulfide bond. The antioxidants are chosen such that at least one has a pro-oxidative effect.
    Type: Application
    Filed: July 14, 2017
    Publication date: November 2, 2017
    Inventor: William H. Cross, III
  • METHODS OF INCREASING FERTILITY OF A MALE SUBJECT WITH COSTUS SPECIOSUS EXTRACT
    Publication number: 20170312330
    Abstract: The present disclosure relates to a method of increasing fertility of a male subject, wherein the male subject suffers from reduced fertility resulting from a medication, wherein the medication inhibits sperm cell production by inhibiting spermatogenesis in a testis of the male subject, and wherein the method comprises administering to the male subject an effective amount of an extract of Costus speciosus in combination with the medication to prevent, and/or reduce the inhibition of sperm cell production by the medication to increase the fertility of the male subject.
    Type: Application
    Filed: November 8, 2016
    Publication date: November 2, 2017
    Applicant: King Abdulaziz University
    Inventors: Dalia Mostafa Mohammed DOMIATY, Sherifa Hassaballa