Patents Issued in November 2, 2017
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Publication number: 20170315081Abstract: A gas sensor element comprises a solid electrolyte layer; a detection electrode provided on one surface of the solid electrolyte layer; a reference electrode provided on another surface of the solid electrolyte layer; a first layer provided on a side where the other surface of the solid electrolyte layer is present, and having a reference gas flow path; and a heater layer provided on a side opposite to a side where the solid electrolyte layer is provided. In the gas sensor element, an introduction flow path is formed as a flow path for guiding the reference gas from outer surfaces of the gas sensor element to the reference gas flow path. The introduction flow path has an opening provided at an outer surface that is perpendicular to a stacking direction of the gas sensor element and is provided on a side opposite to the heater layer.Type: ApplicationFiled: April 26, 2017Publication date: November 2, 2017Applicant: NGK Spark Plug Co., LTD.Inventors: Ai IGARASHI, Kouji TOIDA, Shun SAKUMA
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Publication number: 20170315082Abstract: A gas sensor is equipped with a housing, an insulator retained by an inner periphery of the housing, a sensing device having a front end portion protruding from a front end surface of the insulator, and a protective cover which covers a front end portion of the sensing device. A pump electrode and a sensor electrode are disposed in a front end portion of the solid electrolyte body. The pump electrode is exposed to a measurement gas and regulates the concentration of oxygen in the measurement gas. The sensor electrode is exposed to the measurement gas and measures the concentration of a given gas component in the measurement gas after being regulated in concentration of oxygen by the pump electrode. A base end portion of the sensor electrode in a lengthwise direction is located closer to a base end side of the gas sensor than a front end surface of the housing is.Type: ApplicationFiled: October 20, 2015Publication date: November 2, 2017Inventors: Yuusuke KAWAMOTO, Yuusuke TOUDOU, Takashi ARAKI
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Publication number: 20170315083Abstract: A gas sensor 10 has a measuring channel 11 with a gas inlet 12 and with a gas outlet 13, at least one receptor layer 20, a reference electrode 30 and a voltage-controlled analysis unit 50. The reference electrode 30 is capacitively coupled with the receptor layer 20. The reference electrode 30 is connected to the analysis unit 50 in an electrically conductive manner. The receptor layer 20 is formed in measuring channel 11. The measuring channel 11 forms a dielectric layer between the receptor layer 20 and the reference electrode 30. The receptor layer 20 has a support 21 and an analyte-binding layer 22. The present invention provides for the analyte-binding layer 22 to be a self-assembling monolayer (SAM).Type: ApplicationFiled: November 4, 2015Publication date: November 2, 2017Inventors: Wolfgang BÄTHER, Stefan LEHMANN
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Publication number: 20170315084Abstract: A device includes a biosensor, a sensing circuit electrically connected to the biosensor, a quantizer electrically connected to the sensing circuit, a digital filter electrically connected to the quantizer, a selective window electrically connected to the digital filter, and a decision unit electrically connected to the selective window.Type: ApplicationFiled: July 10, 2017Publication date: November 2, 2017Inventors: Jui-Cheng Huang, Yi-Shao Liu, Chun-Wen Cheng, Tung-Tsun Chen, Chin-Hua Wen
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Publication number: 20170315085Abstract: The present disclosure provides a bio-field effect transistor (BioFET) device and methods of fabricating a BioFET and a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a gate structure disposed on a first surface of a substrate and an interface layer formed on a second surface of the substrate. The substrate is thinned from the second surface to expose a channel region before forming the interface layer.Type: ApplicationFiled: July 14, 2017Publication date: November 2, 2017Inventors: Yi-Shao LIU, Chun-Ren CHENG, Ching-Ray CHEN, Yi-Hsien CHANG, Fei-Lung LAI, Chun-Wen CHENG
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Publication number: 20170315086Abstract: Structures, apparatuses, and methods are provided for fabricating a semiconductor device structure. An example semiconductor device structure includes a first substrate, a first device layer, a second device layer and a third device layer. The first device layer may be on the first substrate and include a switch. The second device layer may be on the first device layer and include a sensing device. The third device layer may include one or more inter-level connection structures configured to electrically connect the switch to the sensing device. The switch may be configured to be electrically turned on in response to a selection signal. The sensing device may be configured to generate an output signal in response to the switch being turned on.Type: ApplicationFiled: July 20, 2017Publication date: November 2, 2017Inventors: Tung-Tsun Chen, Jui-Cheng Huang
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Publication number: 20170315087Abstract: The present invention provides a method for determining whether or not a capillary filled with an electrophoretic medium is suitably used for electrophoresis before electrophoresis is performed using the analytes. The method comprises (a) applying an alternating-current voltage between a first electrode which is in contact with a first electrolyte solution in which one end of the capillary is immersed and a second electrode which is in contact with a second electrolyte solution in which the other end of the capillary is immersed to measure an electric conductivity of the electrophoresis medium with which an inside of the capillary is filled; and (b) determining that the capillary filled with the electrophoresis medium fails to be used suitably for the electrophoresis, when the electric conductivity is more than 4.2 mS/cm.Type: ApplicationFiled: September 29, 2016Publication date: November 2, 2017Inventors: MARI ONODERA, HIDENOBU YAKU
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Publication number: 20170315088Abstract: A sample processing apparatus (102) includes a plurality of processing stations (108) configured to process a sample that includes a DNA sample and an ILS substance carried by a sample carrier. One of the plurality of processing stations includes an electrophoresis processing station. The sample processing apparatus further includes an optical reader (110) that generates a plurality of DNA sample color group signals and an ILS signal based on a result of the electrophoresis processing station. One of the DNA sample color group signals includes at least the locus amelogenin X-peak. The sample processing apparatus further includes an ILS signal validator (112) that validates peaks of the ILS signal as true peaks of the ILS signal only if the amelogenin X-peak of the one of the DNA sample color group signals is found between two peaks of the ILS signal.Type: ApplicationFiled: October 23, 2014Publication date: November 2, 2017Applicant: Analogic CorporationInventor: Ching-Ming LAI
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Publication number: 20170315089Abstract: The present invention discloses a gel electrophoresis chip, comprising a first substrate, a first plurality of parallel gel strips formed on the first substrate, respectively extending along a first direction and having a certain width; and a second plurality of isolation segments formed on the first substrate, respectively located between adjacent gel strips and extending along a second direction different from the first direction, the isolation segments being arranged to form a microwell array together with the gel strips. After the gel electrophoresis chip achieves conventional protein two-dimensional gel electrophoretic separation, protein samples suitable for mass spectrometry analysis are prepared in high throughput, thus greatly reducing the pretreatment time of mass spectrometry analysis, thereby being suitable for proteomic analysis of biological samples.Type: ApplicationFiled: October 20, 2015Publication date: November 2, 2017Inventor: Jian-Bin Bao
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Publication number: 20170315090Abstract: Devices and systems are provided in which one or more electrochemical sensors are integrated within a digital microfluidic device. According to one example embodiment, a two-electrode electrochemical sensor is integrated into a top or bottom plate of a digital microfluidic device, where the counter electrode is provided within a defined spatial region, and where the working electrode is formed such that it is spatially distributed within the spatial region associated with the counter electrode. The working electrode may be provided as one or more elongate segments that are spatially distributed within, and/or surround a perimeter of, the counter electrode. The area of the working electrode may be selected to be smaller than that of the counter electrode in order to improve the performance of the electrochemical sensor.Type: ApplicationFiled: October 21, 2015Publication date: November 2, 2017Inventors: Aaron R. WHEELER, Yue YU, Mohtashim SHAMSI
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Publication number: 20170315091Abstract: Areas having different isotopic ratios are artificially introduced into a metal material before sintering, a heat treatment, or Grain boundary diffusion, and atom probe analysis results before and after sintering, a heat treatment, or grain boundary diffusion are compared to evaluate a change in isotopic distribution over time.Type: ApplicationFiled: December 8, 2014Publication date: November 2, 2017Applicant: HITACHI, LTD.Inventors: Takeshi NAKAYAMA, Masanari KOGUCHI
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Publication number: 20170315092Abstract: The invention relates to methods and instruments for combined separation of ions according to mobility and mass to charge ratio. The mass spectrometric system comprises an ion source, a mobility separator and a mass analyzer wherein the mobility separator comprises (i) a gas filled drift region with a substantially constant electric DC field or a traveling electric field and (ii) an ion storage located adjacent to the entrance or inside the drift region. The ion storage comprises an electric field gradient and a gas flow wherein the electric field gradient and gas flow provide opposing forces on ions in the ion storage such that they are trapped at mobility dependent positions inside the ion storage.Type: ApplicationFiled: April 28, 2016Publication date: November 2, 2017Inventor: Joshua SILVEIRA
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Publication number: 20170315093Abstract: To predict the iron loss of a non-oriented electrical steel sheet after shearing, a non-oriented electrical steel sheet is sheared to a certain width, and iron loss Wt(B0) of the non-oriented electrical steel sheet after shearing is estimated according to a predetermined relational expression based on iron loss Wn(B1) in a non-machining-affected zone in which no machining strain is introduced by the shearing and iron loss Wi(B2) in a machining affected zone in which machining strain is introduced.Type: ApplicationFiled: November 2, 2015Publication date: November 2, 2017Applicant: JFE STEEL CORPORATIONInventors: Takeshi OMURA, Yoshiaki ZAIZEN, Kunihiro SENDA
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Publication number: 20170315094Abstract: A system and method using magnetic sensing to non-intrusively and non-destructively characterize ferromagnetic material within infrastructure. The system includes sensors for measuring magnetic field gradients from a standoff distance adjacent to ferromagnetic material. The method includes using the system to measure magnetic fields, determining magnetic field gradients measured by a sensor array, and comparing measured and modeled or historical magnetic field gradients at the same or similar positions to identify differences caused by a phenomenon in the ferromagnetic material, and, in a particular embodiment, to recognize defects and developing defects.Type: ApplicationFiled: July 18, 2017Publication date: November 2, 2017Inventors: Brian P. Timmons, Rami S. Mangoubi, Zachary R. Hoffman, Franklyn R. Webb
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Publication number: 20170315095Abstract: Methods and apparatus for characterizing composite materials for manufacturing quality assurance (QA), periodic inspection during the useful life, or for forensic analysis/material testing. System are provided that relate eddy-current sensor responses to the fiber layup of a composite structure, the presence of impact damage on a composite structure with or without a metal liner, volumetric stress within the composite, fiber tow density, and other NDE inspection requirements. Also provided are systems that determine electromagnetic material properties and material dimensions of composite materials from capacitive sensor inspection measurements. These properties are related to the presence of buried defects in non-conductive composite materials, moisture ingress, aging of the material due to service or environmental/thermal exposure, or changes in manufacturing quality.Type: ApplicationFiled: July 11, 2017Publication date: November 2, 2017Inventors: Neil J Goldfine, Andrew P Washabaugh, Robert Lyons
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Publication number: 20170315096Abstract: A combination of pulse-amplitude modulation and time division multiplexing is used to increase the scan speed when performing non-destructive inspection, such as with an eddy current array.Type: ApplicationFiled: April 28, 2017Publication date: November 2, 2017Applicant: Olympus Scientific Solutions Americas Inc.Inventor: Gaspard Bastien
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Publication number: 20170315097Abstract: Quantization noise in an oversampled eddy current digital drive circuit is reduced using a noise shaping filter.Type: ApplicationFiled: April 28, 2017Publication date: November 2, 2017Applicant: Olympus Scientific Solutions Americas Inc.Inventor: Benjamin Couillard
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Publication number: 20170315098Abstract: The invention generally provides a system and method for detecting, measuring, and/or classifying particulate and/or water contaminants in a fluid supply line, storage tank, or sump. Embodiments of the invention provide a contaminant detection apparatus with a detection chamber and a detection module. The detection chamber includes a housing with an internal fluid conduit and one or more acoustic transducers disposed in the housing. Alarms and/or automatic signaling may be included to shut off valves or pumps when contaminants are detected.Type: ApplicationFiled: April 29, 2016Publication date: November 2, 2017Inventors: DAVID F. BEERS, MICHAEL R. STRONG, JOHN R. SEVICK, MICHAEL E. MULLEN
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Publication number: 20170315099Abstract: Micromachined ultrasonic transducers integrated with complementary metal oxide semiconductor (CMOS) substrates are described, as well as methods of fabricating such devices. Fabrication may involve two separate wafer bonding steps. Wafer bonding may be used to fabricate sealed cavities in a substrate. Wafer bonding may also be used to bond the substrate to another substrate, such as a CMOS wafer. At least the second wafer bonding may be performed at a low temperature.Type: ApplicationFiled: July 12, 2017Publication date: November 2, 2017Applicant: Butterfly Network, Inc.Inventors: Jonathan M. Rothberg, Susan A. Alie, Keith G. Fife, Nevada J. Sanchez, Tyler S. Ralston
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Publication number: 20170315100Abstract: A method and a test fixture for evaluating a battery cell composed of a cell body having a plurality of electrode foils, a positive terminal and a negative terminal, wherein the positive terminal and the negative terminal are each joined to the cell body at weld junctions. This includes retaining the cell body of the battery cell in a first clamping device. The terminal is grasped in a terminal gripper. A dynamic stress end effector coupled to the terminal gripper applies a vibrational excitation load to the terminal. A static stress end effector applies a static load to the terminal. Integrity of the weld junction is evaluated based upon the applied static load.Type: ApplicationFiled: April 29, 2016Publication date: November 2, 2017Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLCInventors: Wayne W. Cai, Debejyo Chakraborty, Qian Lin, John M. Moote, Anthony Ottomano, Teresa J. Rinker
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Publication number: 20170315101Abstract: A method of ionising a sample is disclosed comprising performing an initial experiment comprising: (i) adding one or more reagents to an analyte sample; (ii) varying the composition and/or concentration of the one or more reagents; (iii) ionising the analyte sample including the one or more reagents; (iv) determining the composition and/or concentration of the one or more reagents which results in a desired, improved or optimised ionisation or other condition or parameter for one or more analytes of interest; and (v) determining one or more first retention times or one or more first retention time windows for the one or more analytes of interest. The method then further comprises separating an analyte sample using a first separation device and during the course of a single experimental run or acquisition varying the composition and/or concentration of one or more reagents which are added to an eluent which emerges from the first separation device.Type: ApplicationFiled: November 5, 2015Publication date: November 2, 2017Inventor: Martin Raymond GREEN
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Publication number: 20170315102Abstract: Aspects of enhanced nanoscale gas chromatography are described. In one embodiment, a nano-scale gas chromatography (GC) module includes a light source, a light detector, and a sensor module having vertically-integrated photonic crystal slab (PCS) Fano resonance filter and GC channel layers. The PCS Fano resonance filter layer includes a hole lattice region, and the GC channel layer comprises a gas channel for separation of analytes in a gas mixture. The gas channel includes a coiled section and an extended length section, where the extended length section extends through a region in the GC channel layer that is stacked in proximity with the hole lattice region. The hole lattice region in the PCS Fano resonance filter layer provides local field enhancement of light generated by the light source for increased light-matter interaction with the analytes in the gas channel.Type: ApplicationFiled: October 20, 2015Publication date: November 2, 2017Inventors: YUZE SUN, WEIDONG ZHOU
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Publication number: 20170315103Abstract: An apparatus comprising: a sensor configured to sense ambient smell; and a processor configured, responsive to the sensor sensing the ambient smell, to determine smell impact based on the ambient smell, and to conduct at least one counter action based on the smell impact.Type: ApplicationFiled: October 31, 2014Publication date: November 2, 2017Inventors: Debmalya BISWAS, Matthew John LAWRENSON, Julian NOLAN
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Publication number: 20170315104Abstract: A determination device determining malfunction of a humidity sensor includes a malfunction determination portion. The humidity sensor includes a humidity detector, a temperature detector and a heater. The humidity detector has a humidity-sensitive film in an intake passage and detects a relative humidity of intake air taken into an internal combustion engine for a vehicle. The temperature detector detects a temperature of the humidity-sensitive film. The heater heats the humidity-sensitive film and the temperature of the humidity-sensitive film is increased by the heater. The malfunction determination portion estimates an estimated relative humidity at a subsequent temperature from an original relative humidity and the subsequent temperature, and compares the estimated relative humidity at the subsequent temperature and an actual subsequent relative humidity to determine malfunction of the humidity detector.Type: ApplicationFiled: April 24, 2017Publication date: November 2, 2017Inventor: Yasushi KONO
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Publication number: 20170315105Abstract: To analyze a generation source of a target component emitted in a form of a gas. To provide a generation source analyzing device comprising an acquiring section which acquires a concentration measurement value of a gas which includes a target component, and a concentration measurement value of a particle component which is generated in association with the gas, and an analyzing section which analyzes a distance from a measurement point to a generation source of the target component based on a concentration measurement value of the gas and a concentration measurement value of the particle component. The acquiring section may acquire a concentration measurement value of a precursor gas which becomes a raw material which generates the particle component, and a concentration measurement value of a secondary generated particle component which is generated from the precursor gas.Type: ApplicationFiled: April 24, 2017Publication date: November 2, 2017Inventors: Naoki TAKEDA, Yoshiki HASEGAWA, Kazuhiro KOIZUMI, Bo LI
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Publication number: 20170315106Abstract: An improved NOx sensor with an NH3 oxidation catalyst. A sensor module may include a support component, a NOx sensing material positioned on the support component, and an NH3 oxidation catalyst. The NH3 oxidation catalyst may be layered on top of the NOx sensing material or the NH3 oxidation catalyst may be positioned upstream of the NOx sensing material such that the NH3 oxidation catalyst selectively converts NH3 to N2 while permitting NOx through to the NOx sensing material.Type: ApplicationFiled: October 27, 2014Publication date: November 2, 2017Applicant: Cummins Emission Solutions, Inc.Inventor: Behnam Bahrami
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Publication number: 20170315107Abstract: The disclosure describes embodiments of an airborne molecular contamination (AMC) monitoring apparatus. The AMC apparatus includes a manifold having a plurality of inlets and one or more outlets. A sampling tube bus fluidly is coupled to the manifold, the sampling tube bus comprising a plurality of individual sampling tubes, each individual sampling tube being fluidly coupled to one of the plurality of inlets. One or more analyzers are each fluidly coupled to one of the one or more outlets of the manifold to analyze fluid drawn into the manifold through one or more of the plurality of individual sampling tubes. A control and communication system coupled to the one or more analyzers. Other embodiments are described and claimed.Type: ApplicationFiled: April 25, 2017Publication date: November 2, 2017Inventors: Tsung-Kuan A. Chou, Pei-Wen Chung, Li-Peng Wang
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Publication number: 20170315108Abstract: The invention relates to methods and devices to identify an infection via light scatter from a tissue surface.Type: ApplicationFiled: April 10, 2017Publication date: November 2, 2017Inventors: Jeong-Yeol Yoon, Robin E. Sweeney
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Publication number: 20170315109Abstract: A nanopore-containing substrate includes a substrate, a membrane on the substrate, and at least one nanoscale electronic element disposed on or embedded in the membrane. The membrane defines at least one nanopore. The nanoscale electronic element is aligned with one of the nanopores such that a shortest distance between an edge of the nanoscale electronic element and the edge of the nanopore is less than 50 nm. The nanopores may be formed by etching through a dielectric layer using a solution while applying a voltage to the nanoscale electronic element relative to the solution. The nanopore-containing substrate can be used to detect or sequence a biopolymer, such as a nucleic acid. The nanopore-containing substrate may be used with a biopolymer detection and/or sequencing system.Type: ApplicationFiled: December 1, 2015Publication date: November 2, 2017Inventors: Jonathan ALDEN, Alejandro CORTESE, Arthur BARNARD, Paul McEUEN
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Publication number: 20170315110Abstract: Systems and methods for monitoring the health status of a subject are provided. In certain embodiments, the method includes: applying a sample provided from a subject to a signal enhancing detector configured to indicate an output that is representative of the sample; processing the output with a device configured to acquire the detector output as input data and process the input data to generate a report; and receiving the report. In certain embodiments, the device is a mobile device. In certain embodiments, the method further includes transmitting the sample-derived data in the device to a remote location where the transmitted data is analyzed; and receiving the results of the analysis. Also provided are systems for use in practicing the methods. Kits for use in monitoring the health status of a subject are also provided.Type: ApplicationFiled: October 20, 2015Publication date: November 2, 2017Inventor: Stephen Y. Chou
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Publication number: 20170315111Abstract: The invention principally relates to a method of detecting a disease agent in blood, comprising: (i) creating a sample infra-red spectrum representative of the blood, with one or more spectral components, each having a wavenumber and absorbance value; (ii) providing a reference database of spectral models, each model having one or more database spectral components of a wavenumber and an absorbance value, wherein the database spectral components identify disease agents; (iii) determining whether one or more database spectral components corresponds to one or more sample spectral components; and (iv) compiling a list of corresponding database components identified.Type: ApplicationFiled: October 23, 2015Publication date: November 2, 2017Inventors: Bayden R. WOOD, Philip HERAUD, David PEREZ-GUAITA
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Publication number: 20170315112Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.Type: ApplicationFiled: July 14, 2017Publication date: November 2, 2017Applicant: SYSMEX CORPORATIONInventors: Keiko YOSHIKAWA, Amane HARADA, Katsuhiro MURAKAMI, Maria KIRIYAMA, Keiko MIWA, Takuya KUBO
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Publication number: 20170315113Abstract: Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.Type: ApplicationFiled: May 31, 2017Publication date: November 2, 2017Applicant: Enzo Life Science, Inc., c/o Enzo Biochem, Inc.Inventors: Jack Coleman, Maciej Szczepanik, Richard Jin
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Publication number: 20170315114Abstract: A biosensor comprises first and second molecular components and is capable of displaying non-protease enzyme activity in response to a binding event mediated by first and second binding partners of the biosensor. The first and second binding partners may bind each other directly or may both bind a target molecule. At least the first molecular component comprises an inhibited non-protease enzyme, whereby the binding event switches the enzyme from a catalytically inactive state to an active state. The second molecular component may comprise a protease that cleaves the first molecular component to release inhibition of the non-protease enzyme of first molecular component. Alternatively, the second molecular component may comprise a trap molecule that binds a bait molecule of the first molecular component to release inhibition of the non-protease enzyme of first molecular component.Type: ApplicationFiled: October 27, 2015Publication date: November 2, 2017Inventors: Viktor STEIN, Kirill ALEXANDROV
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Publication number: 20170315115Abstract: An analyte [25] in a matrix is sensed using a sensing device having a detection probe [21] conjugated to a mediator-receptor [22] that is not a binder for the analyte. The sensor device is provided with mediators [23] conjugated to analyte-receptors [24], where the mediators are selected to bind to the mediator-receptors, and where the analyte-receptors are selected to bind to the analyte. In some embodiments, the mediators are bound to the detection probe by a tether molecule, or tether molecule fragment, or tether domain. In other embodiments, the mediators are not bound to the detection probe. The presence of the analyte is detected by optically or electrically detecting changes of distance between the mediators and the mediator-receptor, indicative of association and/or dissociation events between mediators and mediator-receptor, the characteristics of which are affected by whether the analyte is bound to the analyte-receptor.Type: ApplicationFiled: November 12, 2015Publication date: November 2, 2017Inventors: Menno Willem José Prins, Peter Zijlstra, Lucas Brunsveld
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Publication number: 20170315116Abstract: Provided is an inspection kit that proper inspection can be performed even if a tester drips a remainder of sample. The inspection kit includes: a reagent device having a sample-dripping part, the reagent device being capable of making a sample dripped on the sample-dripping part flow in a first direction from an upstream side toward a downstream side; and a case surrounding the reagent device. A liquid-absorbing part is provided with a portion near the sample-dripping part of the case, the liquid-absorbing part guiding, according to capillary action, the remainder of the sample in a second direction differing from the first direction.Type: ApplicationFiled: October 7, 2015Publication date: November 2, 2017Inventors: Kaori SHIMADA, Kenji NARAHARA
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Publication number: 20170315117Abstract: In some aspects, the present invention provides methods for predicting whether a subject will develop autoantibodies to an anti-TNF? drug during the course of anti-TNF? drug therapy. In other aspects, the present invention provides methods for predicting the level of an anti-TNF? drug in a subject during the course of anti-TNF? drug therapy. Systems for predicting anti-TNF? drug levels and the likelihood of autoantibody formation during the course of anti-TNF? drug therapy are also provided herein. The present invention further provides methods for predicting a clinical outcome (e.g., endoscopic response) of a subject on anti-TNF? drug therapy.Type: ApplicationFiled: April 12, 2017Publication date: November 2, 2017Applicant: Nestec S.A.Inventors: Sharat Singh, Venkateswarlu Kondragunta
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Publication number: 20170315118Abstract: Provided is a method for measuring ADAs appearing in a patient receiving molecular-targeted therapy with a drug or the like in a simpler and more accurate manner. A method for measuring anti-drug antibodies (ADAs) in an analyte to be measured, the method comprising: (1) a step of providing a sample comprising an analyte to be measured for ADAs, the step comprising adding a corresponding drug to an analyte to be measured for ADAs to prepare a sample with a drug-ADAs immune complex formed; (2) a step of contacting the sample prepared in step (1) with a carrier coated with complement Clq, anti-C3d antibody, or anti-Clq antibody; (3) a step of contacting a labeled or non-labeled antibody to a drug corresponding to the ADAs with the coated carrier prepared in step (2); and (4) a step of quantifying the drug-ADAs immune complex binding to the complement Clq, anti-C3d antibody, or anti-Clq antibody.Type: ApplicationFiled: April 27, 2017Publication date: November 2, 2017Applicant: JIMRO Co., Ltd.Inventors: Nobuhito KASHIWAGI, Fumio Saitoh, Kenta Kaneda, Hidetaka Maegawa, Yuko Yagihashi
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Publication number: 20170315119Abstract: A SLE and/or lupus nephritis (LN) biomarker panel comprising a solid support and two or more biomarker detection agents, each biomarker detection agent specific for a corresponding target biomarker selected from a group of target biomarkers listed herein is provided; as well as methods for measuring biomarker levels, predicting, prognosing, monitoring and stratifying patients with SLE including active non-LN SLE and active LN SLE.Type: ApplicationFiled: October 7, 2015Publication date: November 2, 2017Inventors: JOAN E. WITHER, PAUL R. FORTIN, HEATHER N. REICH, JAMES W SCHOLEY, CAROLINA M. LANDOLT-MARTICORENA, CARMEN AVILA-CASADO, PAUL C. BOUTROS
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Publication number: 20170315120Abstract: A composition for detecting biofilm on an eyelid margin includes a dye that binds to the biofilm and a solution that is biocompatible with the eye. A method for detecting biofilm on an eyelid margin of an eye includes applying a solution to the eye or the eyelid margin so that a dye in the solution binds to the biofilm. A handheld camera for detecting biofilm on an eyelid margin of an eye includes a housing, an image sensor, and a lens including a focal length determined by a distance between the lens and the eyelid margin. A method for detecting biofilm on an eyelid margin includes capturing an image of the eyelid margin using a handheld camera and determining if the biofilm is present on the eyelid margin. A system for detecting biofilm on an eyelid margin of an eye includes a composition and a handheld camera.Type: ApplicationFiled: May 2, 2017Publication date: November 2, 2017Inventor: James M. Rynerson
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Publication number: 20170315121Abstract: A cell processing system includes at least one processor connectable to a source container filled with a biological fluid, the at least one processor including a spinning membrane configured to receive and separate target cells from the biological fluid, the target cells exiting at a first outlet, one or more containers selectively connected to the first outlet; and, and a magnet. The system also includes a controller coupled to the at least one processor and configured to operate the spinning membrane to receive biological fluid from the source container and to direct the target cells to one of the one or more containers, to pause to permit magnetic particles to be associated with the target cells, and to operate the spinning membrane to receive the contents of one of the one or more containers with the magnet applied to the target cells associated with the magnetic particles.Type: ApplicationFiled: April 27, 2017Publication date: November 2, 2017Inventors: Christopher J. Wegener, Bret M. Olson, Alaina Schlinker, Steven Binninger, Avnie A. Kadakia, Kyle Thompson, Kyle Wolok, Melanie Hamilton
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Publication number: 20170315122Abstract: An optical engine its use in a bench top flow cytometer, the optical engine having a set of lasers, each focused horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same excitation plane of a flow cell, a set of optics that separate fluorescence of a same wavelength range into different locations in a focal plane of collection optics according to the different lasers by which the fluorescent light is excited; and a detector that selectively detects light from the different locations thereby distinguishing between fluorescence emitted within the same wavelength range as excited by the different lasers.Type: ApplicationFiled: July 15, 2017Publication date: November 2, 2017Inventors: Nan Li, Lingbo Kong, Jian Wu, Tingting Cheng, Yangde Qing, Xiaobo Wang
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Publication number: 20170315123Abstract: Provided herein are methods of detecting and/or monitoring the presence or severity of an immune disorder in a subject, including detecting a frequency of a Th2a subset of CD4+ T cells in a biological sample of the subject. In some embodiments, the detecting includes: (a) detecting a frequency of CD4+ T cells in a biological sample of said subject; (b) detecting a frequency of a Th2a subset of the CD4+ T cells in the biological sample; and (c) comparing the frequency of the Th2a subset with the frequency of the CD4+ T cells.Type: ApplicationFiled: July 18, 2017Publication date: November 2, 2017Inventors: William W. Kwok, Erik Wambre
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Publication number: 20170315124Abstract: The present invention provides an anti-HPV E7 protein monoclonal antibody and the use thereof. The antibody can detect the HPV16 E7 protein with high specificity and recognize the HPV18 E7 protein, thereby it can distinguish between the cancerous cervical epithelial cells and the cervical abnormal or non-cancerous cervical epithelial cells.Type: ApplicationFiled: September 21, 2015Publication date: November 2, 2017Inventors: Xiaojia CHANG, Lijun SHI, Chenglong SHI, Fengli HAN, Yan HUANG
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Publication number: 20170315125Abstract: Methods for detecting, diagnosing and monitoring an epithelial cancer in a patient are described comprising measuring in a sample from the patient Ep-ICD polypeptides and Ep-ICD polynucleotides. Methods for prognosis of breast cancer comprising measurement of nuclear Ep-ICD polypeptides and optionally EpEx polypeptides are provided. The invention also provides kits and compositions for carrying out the methods of the invention. The invention also provides a unique scoring system using immunohistochemical analysis to arrive at an Ep-ICD Subcellular Localization Index (ESLI) score, which is used to arrive at a diagnosis of cancer in a patient, or, more particularly, to identify patients that are in need of aggressive clinical treatment.Type: ApplicationFiled: March 22, 2017Publication date: November 2, 2017Inventors: Paul WALFISH, Ranju RALHAN
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Publication number: 20170315126Abstract: Provided is a method for screening a compound that can specifically suppress the formation of caveolae of cancer cells and can inhibit the activity of various RTKs using a single compound all at once. A method for screening a compound specifically suppressing the formation of caveolae of cancer cells wherein the screening method includes a step for bringing a test compound into contact with a system capable of detecting suppression of the binding of Cavin-1 and CAV1 and a step for selecting a compound having activity to suppress the binding of Cavin-1 and CAV1.Type: ApplicationFiled: September 3, 2015Publication date: November 2, 2017Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUE OF TECHNOLOGYInventors: Takashi TAKAHASHI, Tomoya YAMAGUCHI
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Publication number: 20170315127Abstract: The present invention provides new compositions and methods for treating prostate cancer, e.g., drug-resistant prostate cancer, such as anti-androgen drug (e.g., enzalutamide) resistant and/or castration resistant prostate cancer (CRPC). These new compositions include, but are not limited to, pharmaceutical compositions that include an AR-V7 inhibitor, such as niclosamide. Alternatively, these new compositions can include, but are not limited to, pharmaceutical compositions that include an AKR1C3 inhibitor, such as indomethacin. These new methods include, but are not limited to, methods of administering an AR-V7 inhibitor, such as niclosamide, and/or an AKR1C3 inhibitor, such as indomethacin, to treat patients having prostate cancer. The present invention also provides methods of inhibiting androgen receptor variant expression, e.g. AR-V7, and methods of killing cells expressing AR-V7.Type: ApplicationFiled: April 20, 2016Publication date: November 2, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: ALLEN C. GAO, CHENGFEI LIU, WEI LOU, Chong-xian Pan
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Publication number: 20170315128Abstract: There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin.Type: ApplicationFiled: December 12, 2016Publication date: November 2, 2017Applicant: MOLECULAR HEALTH GMBHInventors: David B. Jackson, Martin Stein, Hartmut Voss, Stephan Brock
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Publication number: 20170315129Abstract: The purpose of the present invention is to provide a novel cancer cell detection method that uses living body-derived cells and that can be used even in cytodiagnosis. In particular, the purpose of the present invention is to provide a novel cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. Provided is a cancer cell detection method that uses living body-derived cells and that includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate.Type: ApplicationFiled: September 24, 2015Publication date: November 2, 2017Applicant: Hirosaki UniversityInventors: Katsuya YAMADA, Ayako SASAKI, Kouki ONO, Kiyoshi TONE
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Publication number: 20170315130Abstract: The invention relates to methods and kits for diagnosing or predicting the likelihood of occurrence of preeclampsia in a subject with no history of the disease.Type: ApplicationFiled: May 1, 2017Publication date: November 2, 2017Inventors: Justin L. Grobe, Mark K. Santillan, Donna Ann Santillan