Abstract: A device for releasing volatile substances comprising a container containing the volatile substances located in a fixed position, and means for generating an air flow in order to release the volatile substances, the means for generating an air flow comprising a movable body, the movement of which generates the air flow; at least one magnet arranged on said movable body; and means for generating magnetic flux, the actuation of which causes the displacement of the movable body by means of the repulsion force between said at least one magnet in the movable body and the magnetic flux. The device enables energy consumption to be improved by using magnetically assisted periodic low-consumption actuation.

Abstract: According to one embodiment, an absorbent article includes a moisture-impervious outer layer, an inner layer substantially co-extensive with the outer layer, and an absorbent layer interposed between the outer layer and the inner layer. The inner layer is treated with at one least substance including dimethicone and/or at least one antimicrobial booster. The absorbent layer is treated with at least one antimicrobial agent.

Abstract: The present disclosure is directed to a thermoresponsive adhesive material. The material comprises a linear, phase-separated polymer having fluorinated polymer units and hydrophobic polymer units. The fluorinated polymer units and the hydrophobic polymer units are randomly ordered along the polymer. The hydrophobic polymer units include a first hydrophobic polymer unit and a second hydrophobic polymer unit. The first hydrophobic polymer unit is chosen from acrylate units or methacrylate units each substituted with one or more linear alkyl groups, linear alkenyl groups or a combination thereof, where at least one of the linear alkyl groups or alkenyl groups has 16 to 20 carbon atoms. The second hydrophobic polymer unit is chosen from acrylate units or methacrylate units each substituted with one or more linear alkyl groups, linear alkenyl groups or a combination thereof, where at least one of the linear alkyl or alkenyl groups of the second hydrophobic polymer unit has 5 to 14 carbon atoms.

Abstract: The invention relates to implant materials that are based on hydraulic cements in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids and that react, when combined or when reacted with an aqueous liquid, to a solid in a cement-type initiation reaction. The invention also relates to the use of these materials as technical, medical-technical and/or pharmaceutical products, especially as bone cements, bone replacement materials, bone glues, dental filling materials and implantable active ingredient carriers.

Abstract: The present invention refers to a process for preparing a biomaterial scaffold said method comprising, (a) providing a hydrogel comprising a fibrin network and a polysaccharide network; (b) subjecting the hydrogel of step a) to a freeze-thawing process to physically crosslink the hydrogel; and (c) subjecting the physically cross-linked hydrogel obtained after conducting the step b), to a lyophilization. The invention also relates to the biomaterial scaffold obtainable by the process as defined above, as well said biomaterial scaffold for its use to partially or completely increase, restore or replace the functional activity of a diseased or damaged oral mucosa.

Abstract: Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally methods and related kits for the repair of articular tissue using the collagen material are provided.

Abstract: The subject matter of the invention is an autopolymerisable two-component prosthetic base material and a method for its production comprising A) at least one liquid monomer component, and B) at least one powdered component, whereby the prosthetic material comprises in components (A) and/or (B) (i) at least one initiator or one initiator system for autopolymerisation, (ii) core-shell particles modified by an elastic phase, and (iii) at least one urethane (meth)acrylate.

Abstract: The present invention relates to a polyethylene glycol hydrogel injection, and, more particularly, to an injection to be administered into a joint (a synovial joint cavity) for the improvement of symptoms of arthritis by containing two separate buffer solutions, wherein a solution (1) contains a polyethylene glycol derivative with an electrophilic functional group and a buffer of pH 3.5 to 6, and a solution (2) contains a polyethylene glycol derivative with a nucleophilic functional group, hyaluronic acid, and a buffer of pH 7.5 to 11. The injection of the present invention is highly biocompatible and long-lasting in the joint, showing the efficacy of pain relief, cartilage protection, and inhibition of inflammation, thus offering the effective prevention and treatment of arthritis.

Abstract: The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.

Abstract: The present invention relates to the controllable degradation, filling-type complex bone implant of multivariant amino acid polymer-organic calcium/phosphorus salts, as well as to the preparative method thereof. The complex bone implant is consisted of multivariant amino acid polymers and medically acceptable organic calcium/phosphorus salts, while the content of organic calcium/phosphorus salts is 20-90% based on the total mass of composite material; the multivariant amino acid polymer is polymerized by ?-aminocaproic acid and at least two other amino acids, in which the molar content of ?-aminocaproic acid is at least 50% of the total molar quantity of amino acid polymers, while the amounts of other amino acids are at least 0.5% of the total molar quantity of amino acid polymers.

Abstract: Systems and methods discussed herein provide for fabricating orthopedic implants one or more shape-memory alloys including TiNi and TiNb and shape-setting the alloys to the geometry appropriate for the orthopedic implant. The shape-setting may include tuning the transformation temperature of the one or more alloys, and a single implant may comprise one or more alloys that may differ in composition, shape-setting process, or both.

Abstract: The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one drug or drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein a combination of the at least one drug being a limus drug and the at least one lipophilic antioxidant being butylated hydroxytoluene is excluded.

Abstract: The invention relates to compounds, compositions, and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.

Abstract: A degradable iron-based alloy stem comprises an iron-based alloy substrate and a degradable polymer in contact with the surface of the substrate. The weight-average molecular weight of the degradable polymer is in the range of [1, 100]*104, and the polydispersity index of the degradable polymer is in the range of (1.0. 50]. The degradable polymer is selected from a degradable polyamino acid that can generate an acidic amino acid after degradation; or a mixture of the degradable polyamino acid and a degradable polyester, or a copolymer of monomers of the two; or a mixture of the degradable polyamino acid and a degradable polymer that does not generate acidic products after degradation, or a copolymer of the monomers of the two; or a mixture of the degradable polyamino acid, the degradable polyester and the degradable polymer that does not generate acidic products after degradation, or a copolymer of monomers of the three, or a mixture of a copolymer of monomers of any two of the three with the remaining one.

Abstract: The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.

Abstract: A method for reducing mucus accumulation in an airway including disposing an implantable device within an airway, wherein the implantable device has a first end, a second end, and an inner surface defining a lumen extending from the first end to the second end; wherein at least a portion of the inner surface has a hydrophobic polymer coating thereon, wherein a polymer coating surface has dynamic water contact angles of 145 degrees or greater; and wherein the implantable device is constructed and arranged to maintain patency of the airway; wherein accumulation of mucus is reduced as compared to a similar implantable device without the hydrophobic portion of the inner surface. An implantable medical device having a superhydrophobic surface and a method of making an implantable medical device having a superhydrophobic surface are also provided.

Abstract: A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

Abstract: A method and apparatus are disclosed for delivering at least one agent to a wound site. The method includes the steps of providing a delivery tube having an outlet at a wound site, covering the wound site with a drape and introducing agent at an agent inlet port of the delivery tube. The agent passes along the delivery tube through the drape to the wound site. The agent can be a wide variety or mixture of fluids such as but not limited to pain relief medicament, anti-biotics, saline solution and/or hydrating fluid.

Abstract: An autotransfusion system for separating fluid constituents includes a centrifuge housing and a rotatable driving member mounted within the centrifuge housing. The rotatable driving member is configured to receive therein and rotationally engage any one of a plurality of centrifuge bowls with different heights. In some embodiments, the centrifuge bowl is integrated with a fluid line organizer to provide for easy and efficient organization of a plurality of different fluid lines incorporated into the autotransfusion system. In some embodiments, the centrifuge bowl and fluid line organizer are easily and efficiently coupled to the centrifuge housing for autotransfusion processing.

Abstract: An implantable hydraulic displacement actuator comprising a biocompatible hydraulic displacement fluid for providing a force inside a human or animal body, wherein said hydraulic displacement actuator preferably is a linear hydraulic actuator for generating a cardiac movement.

Abstract: A heart pump assembly, also referred to as catheter assembly, having a desired anatomical shape is provided. The catheter assembly can include a catheter and a cannula having a bend between a proximal portion and a distal portion. A resting shape of the catheter and the cannula can be selected to allow the distal cannula portion to be positioned at a desired angle relative to an anatomical plane (e.g., a plane of an aortic arch). In some embodiments, a packaging tray can be designed to set the catheter assembly in a desired resting shape. For example, the proximal cannula portion can be positioned at a first angle relative to the catheter, and the proximal cannula portion can be positioned at a second angle out of the plane of the packaging tray via one or more inserts.

Abstract: Mechanical circulatory supports configured to operate in series with the native heart are disclosed. In an embodiment, a centrifugal pump is used. In an embodiment, inlet and outlet ports are connected into the aorta and blood flow is diverted through a lumen and a centrifugal pump between the inlet and outlet ports. The supports may create a pressure rise between about 40-80 mmHg, and maintain a flow rate of about 5 L/min. The support may be configured to be inserted in a collinear manner with the descending aorta. The support may be optimized to replicate naturally occurring vortex formation within the aorta. Diffusers of different dimensions and configurations, such as helical configuration, and/or the orientation of installation may be used to optimize vortex formation. The support may use an impeller which is electromagnetically suspended, stabilized, and rotated to pump blood.

Abstract: The present invention provides an intravascular right ventricular assist device, i.e., the cavo-arterial pump (CAP). Two prototypes of the CAP were developed, including a direct drive CAP and a magnetic drive CAP, demonstrating the feasibility of providing adequate pulmonary support and the feasibility of using axial magnetic couplings for contactless torque transmission from the motor shaft to the pump impeller. The magnetic drive CAP was able to operate up to 18.5 kRPM and produce a maximum flow rate of 1.35 L/min and a maximum pressure head of 40 mm Hg.

Abstract: A method may be provided for the operation of a pump device, which comprises at least one pump as well as a suction element which is connected to the at least one pump and which has a suction opening positioned in a cavity of a body of a patient that sucks a fluid by way of producing a reduced pressure in the suction element, wherein an acceleration is measured and monitored during the operation of the pump device, wherein the reduced pressure in the suction element is reduced at least for a limited reaction time period, given the occurrence of an acceleration variable which lies above a fixed threshold valve. A correspondingly configured pump device may be provided.

Abstract: An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.

Abstract: The present disclosure provides a portable haemodialysis system, comprising at least one haemodialyser configured to purify a biological sample. At least one fuel cell is fluidly connected to the at least one haemodialyser, the at least one fuel cell is adapted to receive oxygen and hydrogen from at least one oxygen and hydrogen storage units to generate energy and water. At least one energy reservoir is connected to the at least one fuel cell which is configured to store the energy generated in the at least one fuel cell. The water generated in the at least one fuel cell is supplied to the at least one haemodialyser for purification of the biological sample, and the energy stored in the at least one energy reservoir is used to power the haemodialyser during operation.

Abstract: A method for producing a hollow fiber pre-product for a dialysis membrane is disclosed. The dialysis membrane includes a distribution of the pore sizes which follows an exponential function such as an e-function. The inverse value of the exponential coefficient (K) is at least 30 nm2. The dialysis membrane includes at least 50 pores per ?m2 and the share of a free flow area at a surface of the dialysis membrane amounts to at least 2.5%.

Abstract: Described are peritoneal dialysis systems and methods that involve the use of crossflow filtration of a used dialysate withdrawn from the peritoneal space of a patient. The filtration forms a retentate containing amounts of an osmotic agent and a permeate containing amounts of water and nitrogen-containing waste products of the patient. The retentate, or a fraction thereof, can be returned to the peritoneal space of the patient to return osmotic agent to the patient. The permeate, or a fraction thereof, can be discarded to discard nitrogen-containing waste products of the patient.

Abstract: The present disclosure describes a device and method to clear solutes from a patient's blood while maintaining fluid balance. In some implementations, the device and method is used to assist the filtration functions of a patient's liver or kidney. The device includes a plurality of hollow fibers that pass through a sequence of alternating filtration chambers and infusion chambers. The filtration chambers filter the patient's blood while the infusion chambers rehydrate the filtered blood.

Abstract: The present disclosure relates to an addition line for adding an infusion solution to a fluid, which flows in an extracorporeal blood circuit, wherein the addition line comprises a pressure release valve or a check valve. It further relates to an extracorporeal blood circuit, a blood treatment apparatus and a method using the addition line.

Abstract: Doxorubicin is extracted from blood using anionic material, such as a resin comprising sulfonated polystyrene divinylbenzene beads, and polyethersulfone membrane, or both. After exposing the resin and/or membrane to blood in order to remove doxorubicin therefrom, the doxorubicin maybe extracted from the resin and/or membrane by exposing the material to an extraction solution, sonicating the extraction solution to enhance release of the doxorubicin, and repeating the exposure and sonication in order to remove substantially all of doxorubicin from the resin.

Abstract: A pressure output device (POD) assembly for sensing fluid pressure in a fluid processing system, is provided. This POD assembly includes a shell defining a shell interior, and a movable diaphragm disposed in the shell interior and separating the shell interior into a flow-through chamber and a pressure sensing side. A sensor port is in fluid communication with the pressure sensing side. An inlet port and an outlet port are in fluid communication with the flow-through chamber. The inlet port and the outlet port define an inlet and an outlet, respectively, of a flow-through channel that passes through the flow-through chamber. A boss protrudes from the interior wall of the shell and extends into the flow-through channel to prevent occlusion of flow under different pressure conditions within the flow-through chamber.

Abstract: Methods and systems for priming a disposable fluid circuit for the processing of a biological fluid are disclosed. The methods and systems allow for variable and configurable priming of the flow path(s) leading to one or more biological fluid source containers.

Abstract: The invention relates to a blood line (108) comprising an infusion site (145) intended to inject into the line a solution comprising: —a first main channel (200) having a first passage section, —a second main channel (220) having a second passage section, —means for the formation (210) of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means (224) defining a reduction (225) in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, —a secondary channel (230) comprising an inlet (231) for letting in the solution and an outlet (232) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.

Abstract: A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump; a venous line; and a heartbeat evaluation system including (i) a first electrode coupled to the arterial line or to a patient, (ii) a second electrode coupled to the venous line, (iii) electronic circuitry communicating electrically with the first electrode and the second electrode to sense an electrical heartbeat signal generated by the patient, and (iv) signal processing configured to use the sensed heartbeat signal to calculate at least one of (a) heart rate, (b) respiration, (c) stroke volume, (d) cardiac output, or (e) central blood volume.

Abstract: A method for detoxifying a patient's blood by removing bilirubin from the patient's blood includes obtaining a batch of blood from the patient; controlling a pH of the blood so as to maintain the pH at approximately pH 7.4; controlling a temperature of the blood so as to maintain the temperature at approximately 37° C.; providing date pit-derived activated carbon; soaking the date pit-derived activated carbon within the blood for approximately 10-16 hours; and returning the detoxified blood to the patient.

Abstract: The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.

Abstract: A system for anal or stomal irrigation comprises a reservoir (102) for an irrigating liquid; a catheter (100) comprising a catheter tip for insertion into the rectum or stoma, a thermo sensor (128) connected to the reservoir for obtaining a measure of a temperature within the reservoir, a tubing system and/or the catheter. A control system (103) operatively connected with the thermo sensor is configured to determine a temperature within the reservoir. A method for predicting a temperature in a reservoir for irrigation liquid is also provided.

Abstract: An enema adapter attaches to a plurality of bottles, shower hoses, or water hoses as the fluid storage vessel or fluid source for body cavity flushing applications, such as enema, douching, or similar applications. The enema adapter directs the flow of water from the into the body cavity for medical or hygienic needs. The enema adapter includes discharge nozzle, a first mounting adapter, at least one discharge opening, and a nozzle cap. The discharge nozzle focuses and directs fluid flow from a fluid reservoir out through the at least one discharge opening into the user's body cavity. The discharge nozzle attaches to the first mounting adapter. The first mounting adapter secures the enema adapter to the fluid reservoir.

Abstract: A package for components of a medical apparatus comprising a plurality of panels defining a container having an interior space. A first component of the medical apparatus is disposed within the interior space. The first component of the medical apparatus comprises a medicament delivery device. At least one of said plurality of panels comprises a lid panel. The lid panel is secured in a closed position, in which it at least partially encloses the interior space, by a further component of the medical apparatus being bonded across an edge of the lid panel. Also disclosed is a medical apparatus comprising such a package with a container of medicament within the interior space of the container.

Abstract: A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle (23) between a shielded position and an exposed position.

Abstract: The invention provides a kit comprising a medical accessory device and a dummy unit. The accessory device comprises first attachment means configured for releasable attachment of the accessory to co-operating second attachment means on an original device having an outer surface defining an original device space envelope. The dummy unit comprises a presentation surface on its external surface, a folded or rolled sheet, as well as dummy attachment means configured for releasable attachment of the accessory device to the dummy unit in co-operation with the first attachment means. By this arrangement the mounting of the accessory device on the original device can be demonstrated on the dummy unit in a simple and effective way.

Abstract: A medical device includes a housing, a power supply, a thermally conductive mounting clamp, a heat shield, and at least one fastener. The housing includes a handle. The power supply is disposed within the housing. The thermally conductive mounting clamp is attached to an outer surface of the housing. The heat shield is disposed within the housing adjacent to the power supply. The heat shield is disposed against at least one interior surface of the handle. The at least one fastener passes through at least one opening in the housing and is in thermally conductive contact with the thermally conductive mounting clamp. Heat generated by the power supply is configured to dissipate from the power supply, through the heat shield, through the at least one fastener, and into the thermally conductive mounting clamp.

Abstract: A connecting arrangement for connecting a syringe to an electromechanical pump for drug infusion is provided. The syringe comprises a hollow cylindrical syringe body having a first, tapered open end for discharging the drug and a second open end. The syringe body is surrounded by connecting means arranged to firmly connect the syringe to the pump in a removable manner, an axially sliding plunger being housed in the syringe body for causing suction and injection of the drug through the first end. The pump comprises a pump body housing electromechanical members comprising a sliding rod partially projecting out of the pump body to cause sliding of the plunger within the syringe body of the syringe connected to the pump. The pump body being provided with connecting means arranged to receive in an engaging configuration the syringe body.

Abstract: A mechanical injection pump wearable by a user to deliver a first fluid and a second fluid, including: a pump body having a first fluid chamber to hold the first fluid and a second fluid chamber to hold the second fluid; a common connector having a first inlet, a second inlet, and a common outlet; a first fluid system including the first fluid chamber, a first button drive connected to the first fluid chamber, and first fluid delivery path between the first fluid chamber and the first inlet; and a second fluid system including the second fluid chamber, a second button drive connected to the second fluid chamber, and second fluid delivery path between the second fluid chamber and the second inlet. Force by the user on the button drive increases pressure within the fluid chamber to drive a predetermined volume of the fluid from the fluid chamber.

Abstract: A drip chamber assembly that functions irrespective of its orientation and in the presence of increased internal pressure is provided.

Abstract: An IV pole base is configured to couple in a tessellating manner to at least one other like IV pole base. The IV pole base can comprise a horizontal rectangular plate having four side edges and a given thickness (at least along the aforementioned side edges). This plate has a plurality of tessellating elements comprising each of a blank and a tab formed at each of the four side edges. The IV pole base further comprises a stabilizing thickening element disposed at a periphery of at least one of the tessellating elements to locally increase the thickness of the IV pole base beyond the thickness of the plate to thereby increase tessellation stability. The plate also includes an IV pole coupler formed centrally thereto, the IV pole coupler being configured to receive and hold an IV pole such that the IV pole extends outwardly perpendicularly to the plate.

Abstract: The disclosure is directed to a pressure sensor of an implantable medical device. The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self-aligning housing shape that occludes an opening in the pump bulkhead of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor.

Abstract: Disclosed are various embodiments for illuminated medical infusion including, for example, a medical infusion system which a medical infusion manifold that includes an integrated source of illumination for illuminating an illuminating medical infusion line.

Abstract: A set connector assembly for a fluid infusion device is provided. The set connector assembly includes a connector having a body. The body defines a graspable portion and a coupling portion, and the coupling portion is to be received within a portion of the fluid infusion device. The graspable portion has at least one locking tab to lock the connector to the fluid infusion device, and the graspable portion is movable relative to the body to move the connector between a first, locked position and a second, unlocked position relative to the fluid infusion device.