Patents Issued in December 19, 2017
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Patent number: 9845257Abstract: The present invention provides a vertical sewage treatment device including an anaerobic chamber, an anoxic chamber, an aerobiotic chamber, and a secondary precipitation chamber, wherein the anaerobic chamber, the anoxic chamber, the aerobiotic chamber, and the secondary precipitation chamber are vertically arranged in sequence from the bottom to the top. According to another aspect, the present invention also provides a sewage treatment method using the foregoing vertical sewage treatment device. The sewage treatment device and method of the present invention have the advantages such as a reduced occupied area, improved oxygenation efficiency, a decreased head loss, a reduced invalid structure volume, and a low heat loss.Type: GrantFiled: October 27, 2014Date of Patent: December 19, 2017Assignee: Chinese Research Academy of Environmental SciencesInventors: Liancheng Xiang, Yonghui Song, Junqi Wu, Siyu Wang, Jianping Li, Xingfa Liu
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Patent number: 9845258Abstract: Compositions and methods and systems for treating wastewater within a wastewater treatment system of described. In an embodiment, a method for treating wastewater may include adding a magnesium compound to wastewater within a wastewater treatment system. The method may also include adding an effective amount of a dispersing agent and one or more of a free magnesium control agent and a seed material to wastewater within the wastewater treatment system to control the formation of struvite scale within the wastewater treatment system. Other compositions and methods are described.Type: GrantFiled: September 13, 2013Date of Patent: December 19, 2017Assignee: Premier Magnesia, LLCInventors: Matthew P. Madolora, Jerry E. Rademan, J. Peter Ahl
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Patent number: 9845259Abstract: An apparatus for filtering water has a valve head and a filtration/purification canister removably mountable thereon. Connecting the canister to the valve head automatically opens a check valve in the valve head to permit water to flow from the valve head into and through the canister, and then back to and through the valve head to an outlet port. Disconnecting the canister from the valve head automatically closes the check valve, stopping the flow of water. A bypass valve is provided in the valve head to permit a sanitizing solution to flow through the valve head and along the lines of the water distribution system to sanitize the system, while bypassing the canister. The outlet port may be directly connected to an appliance that uses water, to eliminate possible contamination that may occur when water is brought indirectly from the outlet port to the appliance instead.Type: GrantFiled: January 3, 2009Date of Patent: December 19, 2017Assignee: General Ecology, Inc.Inventors: Richard T. Williams, Carl Beiswenger
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Patent number: 9845260Abstract: Low strength wastewater such as municipal sewage is treated using an anaerobic digester. In some examples, a wastewater stream is separated into a solids rich portion and a solids lean portion. The solids lean portion is treated, for example to remove nitrogen. The solids rich portion is treated in an anaerobic digester, preferably with influent or recuperative thickening. In another example, the wastewater stream is fed to an anaerobic digester and solid-liquid separation stages downstream of the digester return active bacteria and undigested organics to the digester. Both cases may use a process train comprising treatment in an anoxic tank followed by a nitritation tank with a portion of the effluent from the nitritation tank recirculated to the anoxic tank to provide nitritation and denitritation.Type: GrantFiled: October 7, 2015Date of Patent: December 19, 2017Assignee: Anaergia Inc.Inventors: Juan Carlos Josse, Andrew Benedek, Diana Mourato-Benedek
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Patent number: 9845261Abstract: A method of making a heat treated (HT) substantially transparent coated article to be used in shower door applications, window applications, tabletop applications, or any other suitable applications. For example, certain embodiments relate to a method of making a coated article including a step of heat treating a glass substrate coated with at least layer of or including carbon (e.g., diamond-like carbon (DLC)) and an overlying protective film thereon. The protective film may be of or include both (a) an oxygen blocking or barrier layer, and (b) a release layer, with the release layer being located between at least the carbon based layer and the oxygen blocking layer. The release layer is of or includes zinc oxynitride (e.g., ZnOxNz). Following and/or during heat treatment (e.g., thermal tempering, or the like) the protective film may be entirely or partially removed. Other embodiments of this invention relate to the pre-HT coated article, or the post-HT coated article.Type: GrantFiled: May 18, 2015Date of Patent: December 19, 2017Assignees: Centre Luxembourgeois de Recherches Pour le Verre et la Ceramique S.A. (C.R.V.C.), Guardian Glass, LLCInventors: Jens-Peter Muller, Vijayen S. Veerasamy
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Patent number: 9845262Abstract: A glazing includes a transparent substrate coated with a stack of thin layers including at least one functional metal layer and at least two antireflective coatings, each antireflective coating including at least one dielectric layer, so that each functional metal layer is positioned between two antireflective coatings. The stack includes at least one silver-based functional metal layer including at least 95.0% by weight of silver, with respect to the weight of the functional layer, and from 0.5 to 3.5% by weight of zinc, with respect to the weight of zinc and silver in the functional layer.Type: GrantFiled: November 14, 2014Date of Patent: December 19, 2017Assignee: SAINT-GOBAIN GLASS FRANCEInventor: Sophie Brossard
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Patent number: 9845263Abstract: According to one or more embodiments described herein, an apparatus may hold and retain glass articles during processing. The apparatus may comprise a base frame comprising a bottom support plate and a plurality of ware keepers positioned on the bottom support plate. Each ware keeper of the plurality of ware keepers may comprise a plurality of retention bodies formed from wire segments and defining a ware receiving volume therebetween. Each retention body may comprise one or more of a base connection stem, a seat segment, a body segment, a retention segment, and a lever segment. The seat segments of the retention bodies may form a ware seat positioned above and substantially parallel to the bottom support plate. According to another embodiment, an assembly may comprise a plurality of magazine apparatus.Type: GrantFiled: July 24, 2015Date of Patent: December 19, 2017Assignee: CORNING INCORPORATEDInventor: Kenneth Spencer Morgan
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Patent number: 9845264Abstract: A high temperature composite includes a binder, cement or geopolymer and ceramic filler, negative coefficient of thermal expansion materials of AM2O8 or A2(MO4)3 family or ZrV2O7. The material is compatible with concrete, any ceramics or metals or metal alloy. The material is heat shock resistant and stable in harsh chemical environments and is impermeable to most solvents. The new sealant materials can be used as sealants, heat shock resistant structural materials and coatings.Type: GrantFiled: January 14, 2013Date of Patent: December 19, 2017Assignee: Oceanit Laboratories, Inc.Inventors: Vinod P. Veedu, Ashavani Kumar, Sumil Thapa
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Patent number: 9845265Abstract: A system based on plant or bio-sourced materials selected from among coatings, mortars and concretes of bio-sourced materials comprising a plant or bio-sourced material selected from the group consisting of wood and hemp, and a binder composition comprising a first conventional mineral component and a second component, said system being characterized in that said binder composition has a specific surface area calculated according to the BET method, greater than 10 m2/g, preferably greater than 12 m2/g, in particular greater than 14 m2/g and uses thereof.Type: GrantFiled: December 3, 2014Date of Patent: December 19, 2017Assignee: S.A. Lhoist Recherche et DeveloppementInventors: Peter Ulrike, Daniel Daviller
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Patent number: 9845266Abstract: A fused grain is essentially composed of a matrix of a magnesium aluminum oxide of spinel structure MgAl2O4 and/or of the MgO—MgAl2O4 eutectic, the matrix including inclusions essentially composed of magnesium oxide, the grain exhibiting the following overall chemical composition, as percentages by weight, expressed in the form of oxides: more than 20.0% and less than 50.0% of Al2O3, Al2O3 and MgO together represent more than 95.0% of the weight of the grain, wherein the cumulative content of CaO and ZrO2 is less than 4000 ppm by weight.Type: GrantFiled: March 17, 2015Date of Patent: December 19, 2017Assignee: SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEENInventor: Stéphane Raffy
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Patent number: 9845267Abstract: Provided is a long and large-area graphite film having improved thermal diffusivity and flex resistance, and accompanied by ameliorated ruffling. According to a method for producing a graphite film, in which graphitization of a heat-treated film consisting of a carbonized polymer film is carried out in a state being wrapped around an internal core, the method being characterized in that a heat treatment is executed by controlling distance(s) between the internal core and the film, and/or between the layers of the film, a graphite film accompanied by significantly ameliorated ruffling can be obtained.Type: GrantFiled: January 13, 2016Date of Patent: December 19, 2017Assignee: KANEKA CORPORATIONInventors: Yusuke Ohta, Makoto Mishiro, Takashi Inada, Yasushi Nishikawa
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Patent number: 9845268Abstract: In one aspect, sintered ceramic bodies are described herein which, in some embodiments, demonstrate improved resistance to wear and enhanced cutting lifetimes. For example, a sintered ceramic body comprises tungsten carbide (WC) in an amount of 40-95 weight percent, alumina in an amount of 5-30 weight percent and ditungsten carbide (W2C) in an amount of at least 1 weight percent.Type: GrantFiled: May 23, 2016Date of Patent: December 19, 2017Assignee: KENNAMETAL INC.Inventors: Jason Goldsmith, Sheng Chao
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Patent number: 9845269Abstract: Multifunctional Boron Nitride nanotube-Boron Nitride (BN—BN) nanocomposites for energy transducers, thermal conductors, anti-penetrator/wear resistance coatings, and radiation hardened materials for harsh environments. An all boron-nitride structured BN—BN composite is synthesized. A boron nitride containing precursor is synthesized, then mixed with boron nitride nanotubes (BNNTs) to produce a composite solution which is used to make green bodies of different forms including, for example, fibers, mats, films, and plates. The green bodies are pyrolized to facilitate transformation into BN—BN composite ceramics. The pyrolysis temperature, pressure, atmosphere and time are controlled to produce a desired BN crystalline structure. The wholly BN structured materials exhibit excellent thermal stability, high thermal conductivity, piezoelectricity as well as enhanced toughness, hardness, and radiation shielding properties.Type: GrantFiled: March 29, 2013Date of Patent: December 19, 2017Assignees: National Institute of Aerospace Associates, The United States of America as represented by the Administration of NASAInventors: Jin Ho Kang, Robert G. Bryant, Cheol Park, Godfrey Sauti, Luke Gibbons, Sharon Lowther, Sheila A. Thibeault, Catharine C. Fay
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Patent number: 9845270Abstract: A castable refractory material for use in the manufacture of refractory products including fused silica, ceramic fiber, microsilica and a bonding material comprising colloidal silica.Type: GrantFiled: March 27, 2015Date of Patent: December 19, 2017Assignee: PYROTEK ENGINEERING MATERIALS LIMITEDInventor: Mark Vincent
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Patent number: 9845271Abstract: A catalyst system and a process for methanol to light olefin conversion with enhanced selectivity towards propylene. The catalyst system comprises a honeycomb monolith catalyst support coated with aluminosilicate nanozeolite catalysts on the edges and inside the channels of the support structure. The aluminosilicate nanozeolite catalysts have not been pre-modified with a promoter metal. The catalyst system gives higher hydrothermal stability to the catalyst compared to randomly packed pellet catalysts and allows methanol to be converted to predominantly propylene at a low temperature, with decreased selectivity towards C2, higher olefins and paraffinic hydrocarbons.Type: GrantFiled: July 26, 2017Date of Patent: December 19, 2017Assignee: King Fahd University of Petroleum and MineralsInventors: Mohammad Ashraf Ali, Shakeel Ahmed
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Patent number: 9845272Abstract: The invention relates to the conversion of light hydrocarbon to higher-value hydrocarbon, such as aromatic hydrocarbon, to equipment and materials useful in such conversion, and to the use of such conversion for, e.g., natural gas upgrading. The conversion can be carried out in two stages, with each stage containing a dehydrocyclization catalyst comprising at least one dehydrogenation component and at least one molecular sieve.Type: GrantFiled: August 18, 2016Date of Patent: December 19, 2017Assignee: ExxonMobil Chemical Patents Inc.Inventors: John S. Buchanan, Samia Ilias, Mayank Shekhar, Paul F. Keusenkothen
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Patent number: 9845273Abstract: Provided is a method for producing a chlorohydrocarbon having conjugated double bonds by stereoselectively chlorinating an alcohol having conjugated double bonds. More specifically, provided is a method for producing a chlorohydrocarbon having conjugated double bonds, the method including a step of chlorinating an alcohol having conjugated double bonds with a chlorinating agent in a solvent in the presence of a base and in the absence of metal salt for chlorination of the alcohol, and the alcohol being represented by the formula (1): RCH?CHCH?CH—Z—OH??(1) wherein R represents a hydrogen atom or a linear, branched or cyclic C1-17 monovalent hydrocarbon group which may have at least one double bond or at least one triple bond; and Z represents a linear, branched or cyclic C1-17 divalent hydrocarbon group which may have at least one double bond or at least one triple bond.Type: GrantFiled: February 25, 2014Date of Patent: December 19, 2017Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Yuki Miyake, Takeshi Kinsho, Miyoshi Yamashita, Naoki Ishibashi, Takehiko Fukumoto
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Patent number: 9845274Abstract: Disclosed in the present invention is a chromium-free catalyst for gas-phase fluorination and an application thereof. The precursor of the related chromium-free catalyst for gas-phase fluorination consists of a compound containing iron element, a compound containing rare earth metal element and a compound containing element A, wherein element A is one selected from Ca, Al, Mg and Ti, the precursor is subjected to calcination and fluorination treatment to obtain the chromium-free catalyst for gas-phase fluorination. The precursor of the catalyst is calcined at 400-500° C. and fluorinated with hydrogen fluoride at 350-450° C. to obtain the chromium-free fluorinated catalyst. The catalyst has characteristics of being chromium-free and environment-friendly, good catalytic activity and long life etc. The catalyst can be used for preparing hydrofluoroolefins or hydrochlorofluoroolefins from halohydrocarbons.Type: GrantFiled: August 5, 2014Date of Patent: December 19, 2017Assignee: XI'AN MODERN CHEMISTRY RESEARCH INSTITUTEInventors: Jian Lu, Bo Wang, Yue Qin, Wei Mao, Liangang Kou, Zhenhua Zhang, Fei He, Wei Zhang, Hui Ma, Yangbo Ma, Zhijun Hao, Chunying Li, Yongmei Du, Fengxian Li, Sheng Han
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Patent number: 9845275Abstract: Disclosed are a method of preparing polyaromatic oxide and polyaromatic oxide prepared thereby, wherein the method includes (a) placing a plurality of kinds of polyaromatic hydrocarbons and water in a reactor and then stirring them; (b) increasing the temperature inside the reactor to 150 to 300° C. and then feeding a gas containing 10 wt % or more of oxygen into the reactor to increase the partial pressure of oxygen inside the reactor to 2 to 30 bar; and (c) reacting the plurality of kinds of polyaromatic hydrocarbons with oxygen to oxidize the plurality of kinds of polyaromatic hydrocarbons.Type: GrantFiled: January 15, 2015Date of Patent: December 19, 2017Assignee: LG Chem, Ltd.Inventors: Ji Eun Kim, Won Jae Lee, Yong Jin Choe, Won Jong Kwon, Hyun Nam, Kwon Nam Sohn
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Patent number: 9845276Abstract: The invention is concerned with the issue of how to produce n-pentanal by hydroformylation from feedstock mixtures comprising a small proportion of n-butene and a large proportion of n-butane. Specifically, solutions for further optimizing established processes for hydroformylation of such low-butene mixtures in terms of material utilization are sought. The present invention has for its object to enhance the material utilization of the feedstock mixture in the production of n-pentanal from feedstock mixtures having a small proportion of n-butene and a large proportion of n-butane. The process shall be capable of economic operation on an industrial scale. In particular an existing oxo plant shall be honed to achieve better raw material utilization.Type: GrantFiled: April 19, 2017Date of Patent: December 19, 2017Assignee: Evonik Degussa GmbHInventors: Robert Franke, Lena Altmann, Corinna Hecht, Benedikt Dercks, Hanna Spohr, Horst-Werner Zanthoff
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Patent number: 9845277Abstract: In an embodiment, a method of recovering acetone comprises separating a bisphenol A stream into a bisphenol A product stream and an extraction stream comprising unreacted acetone; recovering the unreacted acetone in a recovery section of the bisphenol A production facility and forming a bisphenol A plant acetone recovery stream comprising methanol and a recovered acetone; introducing the bisphenol A plant acetone recovery stream to a phenol purification plant; and purifying the bisphenol A plant acetone recovery stream in the phenol purification plant to form an acetone product stream. The acetone product stream can comprise a reduced amount of methanol as compared to the bisphenol A plant acetone recovery stream.Type: GrantFiled: February 1, 2017Date of Patent: December 19, 2017Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Mark Erik Nelson, Ahmed Abouelfetouh Youssef
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Patent number: 9845278Abstract: A method for improving preservation stability of 2,2-difluoroacetaldehyde according to the present invention include at least: a first step of forming a “2,2-difluoroacetaldehyde-alcohol composite system” in which a 2,2-difluoroacetaldehyde hemiacetal coexists with an excess alcohol, wherein the total molar amount of the alcohol is 1.15 to 4.00 times the total molar amount of 2,2-difluoroacetaldehyde; and a second step of storing, in a storage container, the “2,2-difluoroacetaldehyde-alcohol composite system” formed in the first step. It is possible by this method to suppress the conversion of the 2,2-difluoroacetaldehyde hemiacetal to a dimer and maintain the original aldehyde activity of the target compound with less composition change over a long term.Type: GrantFiled: June 19, 2015Date of Patent: December 19, 2017Assignee: Central Glass Company, LimitedInventors: Masaaki Takeda, Shinya Akiba, Ryo Nadano
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Patent number: 9845279Abstract: In this invention, a portion of the products from a pyrolysis reactor are reacted in a process to form one or more chemical intermediates.Type: GrantFiled: April 14, 2015Date of Patent: December 19, 2017Assignee: ANELLOTECH, INC.Inventors: Terry Mazanec, Eugene Schmelzer, Fred Pesa, Dennis McCullough, Ruozhi Song, Yu-Ting Cheng
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Patent number: 9845280Abstract: Disclosed is a method of producing an estolide having high structural stability, including: a) preparing a fatty acid mixture from biomass-derived oil; b) separating the fatty acid mixture into a C16 fatty acid and a C18 fatty acid; c) converting the C18 fatty acid into a C18 or C17 linear internal olefin; and d) subjecting the C18 or C17 linear internal olefin and the C16 fatty acid to an estolide reaction, thus obtaining an estolide.Type: GrantFiled: October 15, 2015Date of Patent: December 19, 2017Assignees: SK INNOVATION CO., LTD., SK LUBRICANTS CO., LTD.Inventors: Hee Jung Jeon, Jong su Lee, Yong Woo Kim
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Patent number: 9845281Abstract: Hydroxyethyl (methyl)acrylate is prepared by a process of a combination of a three-stage tubular reactor and a tower reactor, wherein, firstly, a catalyst, a polymerization inhibitor and (methyl) acrylic acid are mixed until the solids are dissolved, then mixed with a part of ethylene oxide and thereafter enter into a first tubular reactor for a reaction, a reaction liquid flowing out from the first tubular reactor is mixed with a certain amount of ethylene oxide and enters into a second tubular reactor for a reaction, a reaction liquid flowing out from the second tubular reactor is then mixed with a certain amount of ethylene oxide and thereafter enters into a third tubular reactor, and a reaction liquid flowing out from the third tubular reactor is then passed through a stage of an adiabatic tower reactor and aged such that a product liquid is obtained from extraction.Type: GrantFiled: July 29, 2014Date of Patent: December 19, 2017Assignee: Wanhua Chemical Group Co., Ltd.Inventors: Junping Li, Haibo Chen, Lichang Zhang, Chunxian Cui, Yuan Li, Weiqi Hua, Jiansheng Ding, Junhua Zhang, Zhaokun Cheng
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Patent number: 9845282Abstract: A catalytic process for synthesizing an ester compound, and a catalytic process for synthesizing an amide compound, wherein a solid-supported palladium catalyst is used to catalyze an alkoxycarbonylation reaction of an aryl halide to form the ester compound, or to catalyze an aminocarbonylation reaction of an aryl halide to form the amide compound. Various embodiments of each of the processes are also provided.Type: GrantFiled: July 7, 2017Date of Patent: December 19, 2017Assignee: King Fahd University of Petroleum and MineralsInventors: Bassam M. El Ali, Mansur B. Ibrahim, Rami K. Suleiman
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Patent number: 9845283Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.Type: GrantFiled: August 9, 2016Date of Patent: December 19, 2017Assignee: INSPYR THERAPEUTICS, INC.Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
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Patent number: 9845284Abstract: A method of obtaining a complex acidic salt of a divalent metal and a dicarboxylic acid includes heating water in a reactor; adding a dicarboxylic acid to the heated water; stirring the water to dissolve the dicarboxylic acid in the heated water to produce a solution or a suspension of the dicarboxylic acid in the heated water; adding MeO to the solution or the suspension, where Me is a divalent metal; continuing the stirring of the solution or suspension until formation of the complex acidic salt Me(AcH)2.nH2O begins, where Ac is an anion of the dicarboxylic acid, and n=0-8; cooling the complex acidic salt to below a temperature of crystallization; sedimenting the complex acidic salt; filtering the complex acidic salt to remove water from the complex acidic salt; and drying the complex acidic salt.Type: GrantFiled: December 4, 2016Date of Patent: December 19, 2017Inventors: Mikhail Lvovich Uchitel, Roman Anatolievich Trunin, Evgenij Iljich Maevskij
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Patent number: 9845285Abstract: The present invention provides crystalline solid and amorphous forms of (?)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (?)-halofenate.Type: GrantFiled: December 3, 2015Date of Patent: December 19, 2017Assignees: CymaBay Therapeutics, Inc., DiaTex, Inc.Inventors: Edward D. Daugs, Eric J. Hagen, Jason A. Hanko, David H. Louks
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Patent number: 9845286Abstract: This invention relates to a process for operating a gas phase phosgenation plant (100) to form an isocyanate (4) by reacting an amine (2) with phosgene (1), in which the gas phase phosgenation plant is shut down by first stopping the amine stream and still maintaining the phosgene stream. After a period of time which corresponds to at least 10 times the residence time of phosgene (1) in the main parts of the gas phase phosgenation plant (100) in regular operation, calculated from the time at which the amine inflow has been completely stopped, the feed of phosgene is also stopped. An inert gas stream (3) is maintained through the amine and phosgene feeding devices and through all the other essential parts of the gas phase phosgenation plant (100) during the shutdown.Type: GrantFiled: March 24, 2015Date of Patent: December 19, 2017Assignee: Covestro Deutschland AGInventors: Thomas Knauf, Wolfgang Lorenz, Friedhelm Steffens, Rainer Bruns, Wolfgang Taube
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Patent number: 9845287Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.Type: GrantFiled: September 28, 2016Date of Patent: December 19, 2017Assignee: AILERON THERAPEUTICS, INC.Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
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Patent number: 9845288Abstract: The present disclosure relates to a t-butylketone binaphthol derivative and a method of preparing the same, the t-butylketone binaphthol derivative being a high-efficiency chiral extracting agent which has a very high chiral selectivity enabling to extract an amino acid from an aqueous solution phase to an organic layer and to facilitate its hydrolysis, and enabling a continuous reuse of the organic layer.Type: GrantFiled: February 17, 2015Date of Patent: December 19, 2017Assignees: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION, AMINOLOGICS CO., LTD.Inventors: Kwan Mook Kim, Haofei Huang
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Patent number: 9845289Abstract: A process for the synthesis of Dapsone and intermediates thereof are described.Type: GrantFiled: July 29, 2015Date of Patent: December 19, 2017Assignee: SEEGPHARM SAInventors: Marco Baratella, Graziano Castaldi, Marta Castaldi, Mauro Gaboardi, Giuseppe Pallanza
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Patent number: 9845290Abstract: The present invention relates generally to methods for forming peroxyformic acid, comprising contacting formic acid with hydrogen peroxide. The methods for forming peroxyformic acid can include adding formic acid with a relatively lower concentration of hydrogen peroxide, or adding formic acid to a peroxycarboxylic acid composition or forming composition to react with hydrogen peroxide in the compositions. The present invention also relates to peroxyformic acid formed by the above methods. The present invention further relates to the uses of peroxyformic acid for treating a variety of targets, e.g., target water, including target water used in connection with oil- and gas-field operations. The present invention further relates to methods for reducing or removing H2S or iron sulfide in the treated water source, improving clarity of the treated water source, or reducing the total dissolved oxygen or corrosion in the treated water source, using peroxyformic acid, including peroxyformic acid generated in situ.Type: GrantFiled: December 17, 2015Date of Patent: December 19, 2017Assignee: Ecolab USA Inc.Inventors: Ramakrishnan Balasubramanian, Junzhong Li, Richard Staub, Victor Keasler, Brian Bennett, Allison Brewster
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Patent number: 9845291Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.Type: GrantFiled: December 17, 2015Date of Patent: December 19, 2017Assignee: Genentech, Inc.Inventors: Jun Liang, Daniel Fred Ortwine, Xiaojing Wang, Steven P. Govek, Mehmet Kahraman, Johnny Y. Nagasawa, Nicholas D. Smith, Simon Charles Goodacre, Nicholas Charles Ray
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Patent number: 9845292Abstract: The present invention relates to compounds of the general formula (I) having a selective FKBP51 ligand scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said selective FKBP51 ligand compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.Type: GrantFiled: September 15, 2014Date of Patent: December 19, 2017Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Steffen Gaali, Felix Hausch, Alexander Kirschner, Xixi Feng, Andreas Bracher, Gerd Ruehter
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Patent number: 9845293Abstract: Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.Type: GrantFiled: February 23, 2016Date of Patent: December 19, 2017Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.Inventors: Simone Zaramella, Emiliano Rossi, Ottorino De Lucchi, Siro Serafini
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Patent number: 9845294Abstract: Provided herein is a method of producing C11, C12, and C13 nylon precursors from oleic acid or esters of oleic acid, the method involving amide formation, ring-closing metathesis, and hydrogenation. Further provided are the products of the method described. Provided herein is a method for producing a lactam, the method comprising the steps of converting oleic acid or an ester of oleic acid into an amide having a general formula of H3C—(CH2)rCH?CH—(CH2)rCONR—(CH2)n-CH?CH2, wherein n is 1, 2, or 3, and R is either hydrogen or benzyl; subjecting the amide to a ring-closing metathesis reaction to produce an intermediate having a general formula of —(CH2)rCONR—(CH2) n-CH?CH2-, wherein n is 1, 2, or 3, R is either hydrogen or benzyl, and both ends are connected to each other; and hydrogenating the intermediate to produce a saturated lactam. In certain embodiments, the saturated lactam has a formula of —NH—(CH2) 10-CO—.Type: GrantFiled: July 2, 2015Date of Patent: December 19, 2017Assignee: The University of ToledoInventors: Kana Yamamoto, Sridhar Viamajala, Sasidhar Varanasi, Ajith Yapa Mudiyanselage, Godwin Ameh Abel
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Patent number: 9845295Abstract: Triphenylethylene compounds of formula (II) as dual aromatase inhibitors and selective estrogen receptors modulators are described. Also described are methods for treating patients of breast cancers, and patients of breast cancer comorbid with osteoporosis, using the described triphenylethylence compounds or pharmaceutical formulations thereof.Type: GrantFiled: November 22, 2016Date of Patent: December 19, 2017Assignee: PURDUE RESEARCH FOUNDATIONInventors: Mark S Cushman, Wei Lv, Li-Ming Zhao
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Patent number: 9845296Abstract: The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis by administering to the patient a 2,5,6-benzimidazole derivative or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 19, 2014Date of Patent: December 19, 2017Assignee: The Research Foundation for The State University of New YorkInventors: Iwao Ojima, Divya Awasthi
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Patent number: 9845297Abstract: The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.Type: GrantFiled: October 16, 2015Date of Patent: December 19, 2017Assignee: Melinta Therapeutics, Inc.Inventors: Erin M. Duffy, Ashoke Bhattacharjee, Hardwin O'Dowd, Marco DeVivo, Yanming Du, Sandra Sinishtaj, Yuanqing Tang, Brian T. Wimberly
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Patent number: 9845298Abstract: The invention provides novel compounds and compositions comprising a 5-HT2B antagonist of formula I: and related methods for treating a person having a disorder characterized by undesirable 5-HT2B receptor signaling, such as migraine, irritable bowel syndrome (IBS), pulmonary arterial hypertension (PAH), fibrosis, hepatocellular cancer, a small intestinal neuroendocrine tumor, cardiovascular disorders, and gastrointestinal (GI) tract disorders.Type: GrantFiled: August 18, 2017Date of Patent: December 19, 2017Assignee: National Institute of Biological Sciences, BeijingInventors: Niu Huang, Yu Zhou, Xingyu Lin
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Patent number: 9845299Abstract: A novel process for the preparation of a fluorolactone derivative of the formula and of its acylated derivative of formula wherein R1 stands for a hydroxy protecting group is described. The acylated fluor lactones of formula V, particularly the benzoyl derivative with R1=benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.Type: GrantFiled: March 9, 2017Date of Patent: December 19, 2017Assignee: GILEAD PHARMASSET LLCInventors: Rongmin Chen, Yuanqiang Li, Jianqiang Zhao, Jianbing Zheng, Guoliang Zhu
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Patent number: 9845300Abstract: The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: February 17, 2017Date of Patent: December 19, 2017Assignee: ADVERIO PHARMA GMBHInventor: Peter Fey
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Patent number: 9845301Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.Type: GrantFiled: July 28, 2016Date of Patent: December 19, 2017Assignee: PFIZER INC.Inventors: Christopher Ryan Butler, Laura Ann McAllister, Elizabeth Mary Beck, Michael Aaron Brodney, Adam Matthew Gilbert, Christopher John Helal, Douglas Scott Johnson, Justin Ian Montgomery, Steven Victor O'Neil, Bruce Nelsen Rogers, Patrick Robert Verhoest, Damien Webb
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Patent number: 9845302Abstract: The invention disclosed herein relates to novel Peribysin E analogs of general formula-I. Further the invention provides simple, economical and short synthesis of Peribysin E and its analogs of Formula I, in good yield and purity leading to the identification of more potent cell adhesion inhibitors.Type: GrantFiled: February 19, 2014Date of Patent: December 19, 2017Assignee: Council of Scientific and Industrial ResearchInventors: Dumbala Srinivasa Reddy, Kishor Laxman Handore
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Patent number: 9845303Abstract: Dapagliflozin compounds and process for dapagliflozin preparation are described. Pharmaceutical compositions comprising dapagliflozin or solvates of dapagliflozin, for the treatment of diabetes are also described.Type: GrantFiled: October 19, 2016Date of Patent: December 19, 2017Assignee: Cadila Healthcare LimitedInventors: Sanjay Jagdish Desai, Jayprakash Ajitsingh Parihar, Mahesh Laljibhai Rupapara
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Patent number: 9845304Abstract: Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a Z,Z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): HC?C—Z1—Y1 to a coupling reaction with an alkynyl halide (2): Y2—Z2—C?C—X by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): Y2—Z2—C?C—C?C—Z1—Y1. In addition, provided is a method for producing a Z,Z-conjugated diene compound by reducing the resulting asymmetric conjugated diyne compound, or the like.Type: GrantFiled: February 3, 2016Date of Patent: December 19, 2017Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Yuki Miyake, Takeshi Kinsho, Miyoshi Yamashita, Naoki Ishibashi, Yusuke Nagae, Akihiro Baba
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Patent number: 9845305Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.Type: GrantFiled: October 18, 2016Date of Patent: December 19, 2017Assignee: CORSAIR PHARMA, INC.Inventors: Cyrus K. Becker, Jürg R. Pfister, Gwenaella Rescourio, Meenakshi S. Venkatraman, Xiaoming Zhang
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Patent number: 9845306Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X3 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: GrantFiled: August 18, 2015Date of Patent: December 19, 2017Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi