Abstract: The present invention relates to ?v?8 antagonists, anti-?v?8 antibodies or immunoconjugates for reducing TGF? activation in an individual. Further provided are compositions comprising one of the ?v?8 antagonists, anti-?v?8 antibodies or immunoconjugates, methods for using the compositions, and related subject matter.

Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.

Abstract: The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.

Abstract: The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.

Abstract: The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising said recognition molecules, methods for the production of said recognition molecules, and to the use of said recognition molecules in the diagnosis and therapy of tumor diseases.

Abstract: Provided are isolated nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens. Also provided are isolated polypeptides and CARs encoded by the isolated nucleic acid molecules, vectors that include the isolated nucleic acid molecules, cells that include the isolated nucleic acid molecules, methods of making the same, and methods for using the same to generate a persisting population of genetically engineered T cells in a subject, expanding a population of genetically engineered T cells in a subject, modulating the amount of cytokine secreted by a T cell, reducing the amount of activation-induced calcium influx into a T cell, providing an anti-tumor immunity to a subject, treating a mammal having a MUC1-associated disease or disorder, stimulating a T cell-mediated immune response to a target cell population or tissue in a subject, and imaging a MUC1-associated tumor.

Abstract: The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

Abstract: The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that expresses human ADAM28. The antibody of the present invention can be a human antibody.

Abstract: The present invention provides a method for the extraction and isolation of soluble arabinoxylan products from cereal grain. Preferably, such soluble arabinoxylan product is any one of soluble arabinoxylan, arabinoxylan-oligosaccharides, xylose, arabinose, ferulic acid and mixtures thereof. Said method comprises partial debranning of whole cereal grains to obtain partially debranned cereal grains followed by roller milling of said partially debranned cereal grains to obtain cereal bran. The method further comprises the mashing of at least part of said cereal bran in water optionally involving the treatment of the mash with any one of an enzyme preparation, an acid, a base, a peroxide or combinations thereof, either simultaneously or sequentially, to solubilize and optionally depolymerize a fraction of the arabinoxylan comprised in said cereal bran. Preferably, said treatment is done with an enzyme preparation containing an endoxylanase.

Abstract: The invention relates to methods for achieving a step increase in the Mooney viscosity in production of high-molecular-weight polybutadiene having >95% by weight content of cis-1,4 units and <1% by weight 1,2-vinyl content, characterized in that 1) at least one monomer selected from butadiene and/or isoprene is polymerized at temperatures of from ?20° C. to 150° C. in the presence of at least one inert, organic solvent and in the presence of at least one catalyst based on neodymium carboxylate, 2) the polymerization is then terminated by addition of protic compounds and 3) then sulphur chlorides are added to the polymer, and prior to addition these sulphur chlorides are treated with a carboxylic acid, fatty acid and/or fatty acid ester.

Abstract: Catalyst systems containing a Ziegler-Natta catalyst component are disclosed. Such catalyst systems can contain a co-catalyst and a supported catalyst containing a fluorided silica-coated alumina, a magnesium compound, and vanadium and/or tetravalent titanium.

Abstract: A first embodiment which is a bimodal polymer having a weight fraction of a lower molecular weight (LMW) component ranging from about 0.25 to about 0.45, a weight fraction of a higher molecular weight (HMW) component ranging from about 0.55 to about 0.75 and a density of from about 0.931 g/cc to about 0.955 g/cc which when tested in accordance with ASTM D1003 using a 1 mil test specimen displays a haze characterized by equation: % Haze=2145?2216*FractionLMW?181*a molecular weight distribution of the LMW component (MWDLMW)?932*a molecular weight distribution of the HMW component (MWDHMW)+27*(FractionLMW*MWDLMW)+1019*(FractionLMW*MWDHMW)+73*(MWDLMW*MWDHMW) wherein fraction refers to the weight fraction of the component in the polymer as a whole.

Abstract: In an embodiment, a polymerization process comprises circulating, with a pump, a reaction mixture slurry in a polymerization loop reactor during a polymerization process, detecting a pressure change in the reaction mixture slurry downstream of the pump, generating, by a pressure controller, a takeoff valve actuation signal for a takeoff valve based on the pressure change, generating, by the pressure controller, a correction to the takeoff valve actuation signal, generating, by the pressure controller, a time delay for the correction, applying the correction to the takeoff valve actuation signal to generate a corrected takeoff valve actuation signal, providing the corrected takeoff valve actuation signal to the takeoff valve after the time delay, and adjusting a position of the takeoff valve in response to providing the corrected takeoff valve actuation signal. The reactor pressure is based on the takeoff valve position.

Abstract: The present invention relates to a method of preparing a heat-resistant resin, a heat-resistant resin, and a heat-resistant ABS resin. According to the preparation method of the present invention, the heat-resistant resin can be prepared at a high polymerization conversion rate within a shortened polymerization time, and the amount of polymerized coagulum and the content of fine particles upon coagulation are decreased. Accordingly, a heat-resistant resin and a heat-resistant ABS resin composition with enhanced heat deflection temperature and processability are provided.

Abstract: The present invention relates to homogeneous sulfur-modified polymer compositions, methods related thereto and an asphaltic concrete mixture.

Abstract: A triboelectrically neutral polymer material which resists charging when contacted with another material is provided. The polymer material comprises at least a first polymer and a second polymer, the first polymer having a first rating on a triboelectric series and the second polymer having a second rating on a triboelectric series that is more negative than the first rating. A method of preparing the polymer material is also provided.

Abstract: A polymerizable composition for photochromic optical materials of the present invention includes a polymerizable monomer (A) having two or more ethylene-based unsaturated groups, an ethylene-based unsaturated polymerizable monomer (B) having one (meth)acrylic group and an aromatic ring, a polythiol (C) having three or more mercapto groups, and a photochromic compound (D), and the molar number of the mercapto groups included in the polythiol (C) is not more than 0.3 times with respect to the total molar number of the ethylene-based unsaturated groups included in the polymerizable monomer (A) and the polymerizable monomer (B).

Abstract: The present invention relates to novel block copolymers comprising at least one mono vinyl aromatic monomer (also referred to as mono vinylarene) and at least one conjugated diene monomer, in particular to styrene butadiene block copolymers (SBC), with a defined block structure. The invention further relates to polymer blends which comprise at least one block copolymer and at least one mono vinylarene acrylate copolymer, in particular a styrene-methyl methacrylate copolymer. Related methods for preparation and articles prepared from the polymer blends are also provided.

Abstract: Concentrates containing specific functionalized diblock copolymers serve as effective additives for improving the cold flow behavior of fuels and oils, the copolymers being derived from a terminally-unsaturated intermediate polymer obtained via a metallocene process involving hydrogen.

Abstract: A polyurea comprises at least urea base units of formula —NH—CO—NH— and additional units. The additional units comprise at least, on the one hand, a secondary alcohol functional group and, on the other hand, an ether, thioether or secondary amine functional group in the alpha position with respect to the secondary alcohol functional group. Such a polymer can be used as an adhesion primer for the adhesive bonding of a substrate, for example, glass or metal, to an unsaturated rubber or as corrosion-resistant protective coating for a metal substrate. Metal reinforcers, such as thread, cord, film or plate, coated can also be coated with such a polymer.

Abstract: A method for preparing high molecular weight poly(L-lactic acid) with high performance, including: a) providing a biogenic guanidine (BG) as a catalyst, and a nontoxic acid salt of an essential metal trace element as an activator (Act), and adding the catalyst, the activator, and L-lactide monomer to a polymerization reactor; b) evacuating under vacuum and charging the polymerization reactor with nitrogen for three consecutive times to remove air, and allowing the L-lactide monomer to undergo bulk polymerization under vacuum. The bulk polymerization includes a first reaction stage and a second reaction stage, which are separately carried out at different temperatures, pressures, and reaction times.

Abstract: The present invention relates to a process for preparing polysiloxane-polycarbonate block cocondensates proceeding from specific polycarbonates and hydroxyaryl-terminated polysiloxanes.

Abstract: The present invention relates to polysiloxane-polycarbonate block cocondensates comprising particular rearrangement structures and having improved rheological properties and melt stability as well as to mouldings and extrudates made from these polysiloxane-polycarbonate block cocondensates.

Abstract: Disclosed are compositions and methods of preparing ionic polyimides. Also disclosed are methods to tune the properties of the ionic polyimide by designing the components of the ionic polyimide. Additionally, disclosed herein is a composition comprising an ionic polyimide. Also disclosed herein is a composition comprising an ionic polyimide and an ionic liquid. The disclosed compositions can be utilized to capture gases.

Abstract: According to one embodiment, a method of dispersing nanoparticles into a destination material includes providing a plurality of nanoparticles suspended in a carrier, adding a solvent to the plurality of nanoparticles suspended in a carrier, removing at least some of the carrier to yield the plurality of nanoparticles suspended in the solvent, mixing the nanoparticles suspended in the solvent with a destination material, and removing at least some of the solvent from the mixture of nanoparticles suspended in the solvent and the destination material.

Abstract: This invention relates to a method for producing functionalized telechelic oligomers, comprising two steps. The first step relates to bringing a raw material comprising at least one high-molecular-weight polymer comprising at least two unsaturations, into contact with a solution comprising at least one metathesis catalyst and at least one functionalizing agent. The second step relates to the separation of the functionalized telechelic oligomers produced by the metathesis reaction in ionic liquid medium of the first step.

Abstract: A fastener comprising a polymer composition [composition (C)] comprising at least one polyaryletherketone polymer [(PAEK) polymer], and at least one nitride (NI) of an element having an electronegativity (?) of from 1.3 to 2.5, as listed in <<Handbook of Chemistry and Physics>>, CRC Press, 64th edition, pages B-65 to B-158, based on the total weight of the composition (C).

Abstract: A rubber compound for tyres comprising a cross-linkable unsaturated chain polymer base comprising, in turn, at least a rubber of synthetic origin, a silica-free filler at least partially comprising carbon black, a vulcanization system and a mercapto carboxylic acid.

Abstract: The present invention provides a rubber composition that can enhance the fuel economy, wet-grip performance, abrasion resistance, and kneading processability in a balanced manner, and a pneumatic tire using this rubber composition. The present invention relates to a rubber composition that contains a rubber component and silica, wherein the rubber component contains, based on 100% by mass of the rubber component, 10 to 70% by mass of a high-cis polybutadiene having a cis content of 95% by mass or more and satisfying the following requirements (A) to (C): (A) a Mooney viscosity (ML) of 40 to 49; (B) a molecular weight distribution (weight-average molecular weight (Mw)/number-average molecular weight (Mn)) of 3.0 to 3.9; and (C) an index (n-value in Expression (1) below) of velocity dependence of Mooney viscosity of 2.3 to 3.

Abstract: The present invention provides the following multilayer heat-shrinkable styrene-based film having an appropriate surface shape, together with excellent lubricity and blocking resistance, and resistance to ink skipping and like problems during the printing process: a multilayer heat-shrinkable styrene-based film having: layers (A) each containing 0.8 to 2.5 parts by weight of high impact polystyrene resin and 0.02 to 0.15 parts by weight of organic fine particles having a mean particle diameter of 0.5 to 5 ?m per 100 parts by weight of a block copolymer of 75 to 90 wt % vinyl aromatic hydrocarbon and 10 to 25 wt % conjugated diene hydrocarbon; and a layer (B1) containing a block copolymer of 70 to 85 wt % vinyl aromatic hydrocarbon and 15 to 30 wt % conjugated diene hydrocarbon; or a layer (B2) containing a resin composition containing a copolymer of 98 to 40 wt % vinyl aromatic hydrocarbon and 2 to 60 wt % aliphatic unsaturated carboxylic acid ester.

Abstract: A curable resin composition comprising: a) an epoxy resin; b) an anhydride hardener; c) a polyol; d) a core shell rubber, and (e) a catalyst, is disclosed. When cure the resin composition can be used to formulate composites, coatings, laminates, and adhesives.

Abstract: This invention generally relates to transparent compositions containing a blend of poly(phenylene ether) and styrenic polymer, methods for their manufacture, and food packaging films and containers derived therefrom.

Abstract: A polyamide molding material is proposed, which comprises at least one partially crystalline, partially aromatic polyamide (A) and at least one amorphous polyamide (B). The polyamides (A) and (B) together make up 30-60 wt.-% of the polyamide molding material. Furthermore, the polyamide molding material comprises 40-70 wt.-% glass fibers (C) having flat cross section, 0-15 wt.-% of at least one nonhalogenated flame retardant (D), and 0-10 wt.-% further additives (E), the components (A) to (E) adding up to 100 wt.-% of the polyamide molding material. The at least one partially crystalline, partially aromatic polyamide (A) has a glass transition temperature of at least 105° C. The polyamide molding material according to the invention is preferably distinguished in an injection-molding burr formation test in that, at a melt temperature of 320° C. and a tool temperature of 90° C.

Abstract: Provided are processes for producing fluorescent naphthalimide diesters of Formula (I), useful as fluorescent tracer dyes for fluid system leak detection, wherein each of R1 and R2 is, independently of the other, a saturated, linear hydrocarbon chain having from 2 to 10 carbon atoms; and each of Z1 and Z2 is, independently of the other, a fatty acid moiety having a saturated or unsaturated, linear or branched, hydrocarbon chain having from 8 to 24 carbon atoms, and from 0 to 4 double bonds. Also provided are compositions of the aforesaid diesters of Formula (I).

Abstract: The invention relates to polymer compositions containing inorganic or organic particles which either have been surface-treated before the production of the compositions or are dispersed by special polyether-modified siloxanes through the production of the compositions.

Abstract: Disclosed is a hard coating including a chemical composition specified by formula: (TiaAlbSicRd)Ox, where R represents at least one rare-earth element; and a, b, c, d, and x are atomic ratios respectively of Ti, Al, Si, R, and O. The atomic ratios meet conditions as specified by formulae: 0.30?a?0.7, 0.30?b?0.70, 0?c?0.2, 0.005?d?0.05, a+b+c+d=1, and 0.5?a/b<1. The atomic ratios meet a condition as specified by Formula (1) when R does not include Ce. The atomic ratios meet a condition as specified by Formula (2) when R includes Ce. The hard coating has better wear resistance as compared with conventional nitride films and oxide films. 0.8?[x/(2a+1.5b+2c+1.5d)]?1.2??(1) 0.8?[x/(2a+1.5b+2c+2d)]?1.

Abstract: Embodiments of invention provide a method for producing a hard coat film which has a hard coat that is formed from an active energy ray-curable resin composition on at least one surface of a film base. According to at least one embodiment, the active energy ray-curable resin composition used in this method contains (P) 100 parts by mass of a urethane (meth)acrylate compound, (Q) 0.02-5 parts by mass of organic fine particles having an average particle diameter of 10-300 nm, and (R) 0.0002-2 parts by mass of an acrylic silicone-based leveling agent. The method according to at least one embodiment includes the steps of (1) forming a wet coating film by applying the active energy ray-curable resin composition to the film base, (2) forming a dry coating film by drying the wet coating film, and (3) forming a hard coat film by curing the dry coating film by means of active energy ray irradiation at a temperature of 50-90° C.

Abstract: Provided are a method for easily and quickly producing a patterned thin film having a high refractive index and a high transparency, and a highly refractive thin film produced by the method. The method comprises a first step: a step of forming, on a substrate, a coating using a sol containing a metal oxide modified with a phosphorus compound represented by the following formula (1): (wherein R1 is a hydrogen atom, an alkyl group, an alkynyl group, an alkenyl group, an aryl group, an aliphatic heterocyclic group, or an aromatic heterocyclic group; R2 is a divalent organic residue; and n is 1 or 2); a second step: a step of curing the coating on the substrate obtained in the first step by light irradiation; and a third step: a step of further adding energy to the cured film obtained in the second step by heating and/or light irradiation.

Abstract: Provided are an antifouling coating composition that contains: a hydrolyzable resin having a specific silicon-containing group and a metal-atom-containing group containing a divalent metal atom M; and a thermoplastic resin and/or a plasticizer, wherein the total content of the thermoplastic resin and/or plasticizer per 100 parts by mass of the hydrolyzable resin is 3 to 100 parts by mass, an antifouling film, a composite film and an in-water structure such as a ship using the antifouling coating composition. The antifouling coating composition makes it possible to form a coating film that is excellent in crack resistance and exhibits a good antifouling property over a long period of time even when no antifouling agent is contained or the blending amount thereof is small.

Abstract: The present disclosure relates generally to the field of static dissipative coatings. More specifically, the present disclosure relates to the methods of making static dissipative, preferably non-chromium-containing, coatings comprising carbon nanotubes, the coatings themselves, and structures comprising such coatings.

Abstract: A method for producing a binder resin by a reaction of a cellulose derivative, a polyvinyl acetal, and a bonding agent that has in the molecule at least two functional groups that can react to hydroxyl groups in the polyvinyl acetal and the cellulose derivative. In the production method, the content of the bonding agent is at least double the molar quantity of whichever has the greater number of moles between the polyvinyl acetal and the cellulose derivative. The produced binder resin is favorable in a coating paste such as a conductive paste, and causes an improvement in film quality such as the smoothness and denseness of a coating film formed by the paste.

Abstract: The present invention provides a magnetic multilayer pigment flake and a magnetic coating composition that are relatively safe for human health and the environment. The pigment flake includes one or more magnetic layers of a magnetic alloy and one or more dielectric layers of a dielectric material. The magnetic alloy is an iron-chromium alloy or an iron-chromium-aluminum alloy, having a substantially nickel-free composition. The coating composition includes a plurality of the pigment flakes disposed in a binder medium.

Abstract: The present application provides a sublimation ink which is capable of being transferred to natural fiber fabrics, such as cotton and linen, in addition to synthetic fabrics, such as polyester, nylon, etc., and shows significantly improved color fastness. The sublimation ink may include a resin containing at least one active hydrogen, a crosslinking agent having at least two isocyanate (—NCO) groups, and one or more colorants. The sublimation ink may also include one or more carriers, binders, thickeners, and/or solvents. An image can be printed on a transfer medium (e.g. paper) at room temperature with the sublimation ink using conventional offset printer so that the sublimation ink remains inactive. The image can be subsequently transferred onto any desired fabrics under heat and pressure, in which the sublimation ink is activated and bonds the colorant to the fabrics with excellent color effect.

Abstract: The invention describes the use of a water-based UV curable inkjet printing ink wherein the ink is basic due to the presence of a tertiary amine, allowing the complete dissolution of an acid functional photoinitiator of Formula I or Formula IA (wherein R1, R2, R3, n, q, and y are as defined herein). This combination of photoinitiator and tertiary amine allows the rapid low dosage UV curing of a water-based UV formulation using a UV LED light source.

Abstract: The present invention is related to a surface control additive for a radiation curing system, the method for its preparation as well as its application. The surface control additive has the following structure: wherein A is wherein m is an integer from 0 to 400, n is an integer from 1 to 500, x is an integer from 0 to 800, p is an integer from 0 to 600, q is an integer from 1 to 800, R4 and R5 are H or CH3 respectively, R6 is H or a linear or a branched alkyl group containing 1-18 carbon atoms or an acyl group containing 2-5 carbon atoms. The surface control additive of the present invention is applied to radiation curing (UV/EB) paint and inks, enables the coatings to maintain non-adhesive and smooth for a long time, and minimizes transferable precipitates from a cured film. In addition, by using different combinations of EO and PO, the surface control additive of the present invention can adapt to a free selection from high-polarity aquosity to a low-polarity aliphatic hydrocarbon solvent system.

Abstract: An oil-based inkjet ink set including two or more liquid compositions, for use with an inkjet head having two or more discharge port arrays, wherein at least one of the two or more liquid compositions is an oil-based inkjet ink, the initial boiling point of each of the two or more liquid compositions is, independently, 280° C. or higher, and the difference in the specific gravities of any pair of liquid compositions in the two or more liquid compositions is at least 0.005 but not more than 0.012, is disclosed. A method for producing a printed item is also disclosed.

Abstract: Provided is an ink image matter generating method for selecting a fluorescent ink by performing (a) a process of color-measuring a target color which is a target of color reproduction on a medium and the medium on which an inkjet color ink for color reproduction of the target color is printed; (b) a process of calculating a difference between a colorimetric value of the target color and a colorimetric value of the medium on which the color ink is printed; and (c) a process of selecting a fluorescent ink for reducing the difference between the colorimetric value of the target color and the colorimetric value of the medium on which the color ink is printed, from fluorescent inks that are set in advance, and jetting droplets of the selected fluorescent ink together with the color ink, or after the droplets of the color ink are jetted to cause the fluorescent ink to exist on a surface of an ink image matter, thereby making it possible to select and use an appropriate fluorescent ink with respect to a specific col

Abstract: Provided are a conductive composition for thin film printing and a method for forming a thin film conductive pattern, which can easily performing thin film printing, and can capable of improve conductivity by thermal sintering at a comparatively low temperature of 300° C. or less or by photo irradiation. A conductive composition comprises metal particles, a binder resin, and a solvent, the content of an organic compound in the solvent being 5 to 98% by mass, the organic compound comprising a hydrocarbon group having a bridged cyclic structure and a hydroxyl group, the content of metal particles being 15 to 60% by mass, the metal particles containing 20% by mass or more of flat metal particles, the content of the binder resin being 0.5 to 10 parts by mass relative to 100 parts by mass of the metal particles, and the viscosity at 25° C. being 1.0×103 to 2×105 mPa·s.

Abstract: The invention relates to an aqueous coating composition of nano cellulose (e.g., microfibrillated cellulose), characterized in that has a dry matter concentration of 2%-12% of nano cellulose and comprises at least one cationic surfactant, which may be chosen among Hexadecyltrimethyl-ammonium bromide, Octadecyltrimethyl-ammonium bromide, Hexadecylpyridinium chloride and Tetradecyl trimethyl-ammonium bromide, Dodecyl pyridinium chloride. The invention also pertains to use of the composition as a coating layer and as an oxygen barrier layer. Further it relates to substrates, e.g., board, cardboard or paper coated with the composition. Moreover, the invention pertains to a process for preparing the coating composition.

Abstract: This invention relates to a coating comprising prepolymer and monomers for application onto polyurethane for chemical resistance, abrasion resistance, water proof etc. Usually polyurethane is porous and does not have sufficient stain, abrasion and chemical resistance. The said coatings developed using technology of chemical grafting that involves the use of prepolymers, monomers, catalyst, graft initiator, wetting agents, fillers and other ingredients of the composition. The coating thus obtained when applied on the polyurethane allows obtaining graft polymerization, thereby forming a polymeric film chemically attached to the substrate. The polyurethane substrate is reacted with graft initiator which creates the reaction sites on the substrate via free radical mechanism.