Patents Issued in December 28, 2017
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Publication number: 20170369798Abstract: An olefin or a slack wax of 10 to 100 carbon atoms is oxidized by mixing said wax with a salt of an alkaline earth metal in an amount to provide 0.001 to 0.03 weight percent of the alkaline earth metal, the anion of the salt comprising 4 to 36 carbon atoms; heating the mixture to 100 to 180° C.; and supplying to the heated mixture a molecular oxygen-containing gas. The oxidation is conducted in the substantial absence of manganese or cobalt compounds. The oxidized wax may be esterified by reaction with an alcohol. The oxidized wax may be used in a coating composition.Type: ApplicationFiled: December 14, 2015Publication date: December 28, 2017Inventors: Jennifer E. Clark, Ben Faber, Gregory E. Moran, Britt A. Minch, David Boothe, Daniel J. Hunt, Miranda H. Koenig
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Publication number: 20170369799Abstract: A process to prepare paraffins and waxes is provided, the process comprising: subjecting a Fischer-Tropsch product stream comprising paraffins having from 10 to 300 carbon atoms to a hydrogenation step, thereby obtaining a hydrogenated Fischer-Tropsch product stream comprising 10 to 300 carbon atoms; separating the hydrogenated Fischer-Tropsch product stream, thereby obtaining at least a fraction comprising 10 to 17 carbon atoms and a fraction comprising 18 to 300 carbon atoms; separating the fraction comprising 18 to 300 carbon atoms, thereby obtaining one or more first light waxes having a congealing point in the range of 30 to 75° C. and a second heavy wax having a congealing point in the range of 75 to 120° C.; and hydrofinishing one or more wax fractions having a congealing point in the range of 30 to 75° C. thereby obtaining one or more hydrofinished wax fractions having a congealing point in the range of 30 to 75° C.Type: ApplicationFiled: December 29, 2015Publication date: December 28, 2017Inventors: Arend HOEK, Antonius Adrianus Maria ROOVERS, Kaushik MAJUMDER, Hélène TOLEDANO
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Publication number: 20170369800Abstract: A method of optimizing system parameters in a crude unit to reduce corrosion and corrosion byproduct deposition in the crude unit is disclosed and claimed. The method includes measuring or predicting properties associated with the system parameters and using an automated controller to analyze the properties to cause adjustments in the chemical program to optimize the system parameters. Adjusting the system parameters effectively controls corrosion in the crude unit by reducing the corrosiveness of a fluid in the process stream and/or by protecting the system from a potentially corrosive substance. System parameter sensing probes are arranged at one or more locations in the process stream to allow accurate monitoring of the system parameters in the crude unit.Type: ApplicationFiled: September 8, 2017Publication date: December 28, 2017Applicant: ECOLAB USA INC.Inventors: Glenn L. Scattergood, Sam Ferguson
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Publication number: 20170369801Abstract: An apparatus and a method for gasifying carbon-containing materials in which the material for gasification and oxygen, usually in the form of air, are supplied to a gas generator where the gasification takes place in a fixed bed reactor. The product gas is drawn off via a product gas line and introduced into a hot gas filter. A filter, preferably provided with filter candles, removes solids such as particles not yet gasified, ash and foreign bodies, while clean gas passes through and is taken off via a clean gas line. An outlet is provided in the bottom region of the hot gas filter to remove residual solids. The hot gas filter is supplied through a line with oxygen, preferably in the form of air, in its middle height region, between the filter bottom and the outlet.Type: ApplicationFiled: July 7, 2016Publication date: December 28, 2017Inventor: Gaston GLOCK
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Publication number: 20170369802Abstract: The present invention relates generally to the generation of bio-products from organic matter feedstocks. More specifically, the present invention relates to the use of pulping liquors in the hydrothermal/thermochemical conversion of lignocellulosic and/or fossilised organic feedstocks into biofuels (e.g. bio-oils) and/or chemical products (e.g. platform chemicals).Type: ApplicationFiled: April 13, 2017Publication date: December 28, 2017Inventors: William Rowlands, Leonard James Humphreys, Robert Downie, Paul Watson
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Publication number: 20170369803Abstract: There is described a biodiesel composition and process for producing biodiesel and related products. There is also described related fuels and fuel blends comprising biodiesel. The biodiesel composition may be prepared from a mixture comprising fats, oils and greases from sewer waste.Type: ApplicationFiled: September 8, 2017Publication date: December 28, 2017Applicants: Argent Energy (UK) Limited, Argent Energy LimitedInventor: Michael Scott
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Publication number: 20170369804Abstract: Systems, processes, and catalysts are disclosed for obtaining fuels and fuel blends containing selected ratios of open-chain and closed-chain fuel-range hydrocarbons suitable for production of alternate fuels including gasolines, jet fuels, and diesel fuels. Fuel-range hydrocarbons may be derived from ethylene-containing feedstocks and ethanol-containing feedstocks.Type: ApplicationFiled: August 18, 2017Publication date: December 28, 2017Applicant: Battelle Memorial InstituteInventors: Michael A. Lilga, Richard T. Hallen, Karl O. Albrecht, Alan R. Cooper, John G. Frye, Karthikeyan Kallupalayam Ramasamy
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Publication number: 20170369805Abstract: Processes for producing high biogenic concentration Fischer-Tropsch liquids derived from the organic fraction of municipal solid wastes (MSW) feedstock that contains a relatively high concentration of biogenic carbon (derived from plants) and a relatively low concentration of non-biogenic carbon (derived from fossil sources) wherein the biogenic content of the Fischer-Tropsch liquids is the same as the biogenic content of the feedstock.Type: ApplicationFiled: August 21, 2017Publication date: December 28, 2017Inventors: Stephen H. Lucas, Peter G. Tiverios, Lewis L. Rich
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Publication number: 20170369806Abstract: A liquid fuel derived from processed biomass having extremely low water content and suitable for use in diesel engines or as an additive to petroleum based fuels, or which can be used as a petroleum or coal slurry substitute in those uses where a lower cost fuel have reduced emission is desired, is described.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: Permanente CorporationInventors: Marc Seidner, Leo Seidner, Hanya Seidner
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Publication number: 20170369807Abstract: A lubricant including an ionic liquid including a conjugate base and a conjugate acid, wherein the conjugate acid is represented by General Formula (A) below, and wherein a pKa of an acid that is a source of the conjugate base in acetonitrile is 10 or less, where, in General Formula (A), R is a group including a straight-chain hydrocarbon group having 6 or greater carbon atoms, and R1 and R2 are each independently a hydrocarbon group.Type: ApplicationFiled: June 23, 2017Publication date: December 28, 2017Inventors: Hirofumi Kondo, Kouki Hatsuda, Nobuo Tano, Pankaj Baghel
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Publication number: 20170369808Abstract: A lubricating oil composition for an internal combustion engine including: (A) a lubricant base oil having a kinematic viscosity at 100° C.Type: ApplicationFiled: June 19, 2017Publication date: December 28, 2017Applicant: JXTG NIPPON OIL & ENERGY CORPORATIONInventor: Shintaro KUSUHARA
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Publication number: 20170369809Abstract: The disclosed technology relates to an additive composition and lubricating grease composition containing a synergistic combination of ingredients for inhibiting rust, particularly rust on mechanical devices subject to contact with salt water.Type: ApplicationFiled: December 21, 2015Publication date: December 28, 2017Inventor: Scott Capitosti
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Publication number: 20170369810Abstract: The present invention relates to a lubricating composition containing: an oil of lubricating viscosity, a non-borated dispersant, a detergent, and an antiwear package comprising (a) a derivative of a hydroxycarboxylic acid, (b) an amine salt of a phosphoric acid ester, and (c) a phosphite having at least one hydrocarbyl group with 4 or more carbon atoms. The invention further provides for a method of lubricating a driveline device application by employing a lubricating composition containing the antiwear package.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Inventor: William R.S. Barton
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Publication number: 20170369811Abstract: Provided is a lubricating oil composition to be used in an internal combustion engine having a sliding mechanism including a piston ring and a liner, the lubricating oil composition including: a base oil; (A) a poly(meth)acrylate; and (B) an organic molybdenum compound, in which: (A) the poly(meth)acrylate contains a polymer (A1) including a repeating unit derived from a (meth)acrylate represented by the following formula (1) and having a mass-average molecular weight of from 1,000 to 500,000; and a content of (B) the organic molybdenum compound in a total amount of the composition is from 0.01 mass % to 0.2 mass % in terms of a molybdenum atom: wherein R1 represents a hydrogen atom or a methyl group, and X represents a hydrogen atom, a hydrocarbon group having 1 to 60 carbon atoms, or a functional group-containing hydrocarbon group having 1 to 60 carbon atoms.Type: ApplicationFiled: January 15, 2016Publication date: December 28, 2017Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Moritsugu KASAI
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Publication number: 20170369812Abstract: A method for inhibiting adsorption of ?-olefin in a lubricant composition to a metal surface is disclosed. The lubricant composition comprises any of oils of Group III, Group IV and polyisobutylenes classified into Group V according to the API base oil classification or a mixture thereof as a base oil, and the ?-olefin coexisting in an amount of 1% by mass or less based on the total amount of the composition. The method comprises adding a sarcosinic acid derivative, an aspartic acid derivative or a diethanolamine derivative, or a mixture thereof to the lubricant composition.Type: ApplicationFiled: December 14, 2015Publication date: December 28, 2017Applicant: SHELL OIL COMPANYInventors: Hiroyuki TAZAKI, Mitsuhiro NAGAKARI, Hiroshi KANEKO
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Publication number: 20170369813Abstract: A dielectric nanolubricant composition is provided. The dielectric nanolubricant composition includes a nano-engineered lubricant additive dispersed in a base. The nano-engineered lubricant additive may include a plurality of solid lubricant nanostructures having an open-ended architecture and an organic, inorganic, and/or polymeric medium intercalated in the nanostructures and/or encapsulate nanostructures. The base may include a grease or oil such as silicone grease or oil, lithium complex grease, lithium grease, calcium sulfonate grease, silica thickened perfluoropolyether (PFPE) grease or PFPE oil, for example. This dielectric nanolubricant composition provides better corrosion and water resistance, high dielectric strength, longer material life, more inert chemistries, better surface protection and asperity penetration, no curing, no staining, and environmentally friendly, compared to current products in the market.Type: ApplicationFiled: August 11, 2017Publication date: December 28, 2017Applicant: The Board of Trustees of the University of ArkansasInventors: Ajay P. Malshe, Wengyang Zhang
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Publication number: 20170369814Abstract: Disclosed is a lubricating composition including a base oil, a surfactant system and a phase-change material, especially water. The lubricating composition according to the invention is used to lubricate engines, especially for a vehicle. It has improved thermal performances compared to lubricating compositions of prior art. It also reduces clogging of the engine parts.Type: ApplicationFiled: December 22, 2015Publication date: December 28, 2017Inventor: Nicolas OBRECHT
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Publication number: 20170369815Abstract: A method of separating oil from a composition containing an oil and water emulsion, by adding a separation additive which is a mixture of a fatty ester of an alkoxylated polyol and a fatty ester of alkoxylated glycerol, and performing at least one oil separation step. The method is particularly suitable for separating corn oil from stillage produced in a corn ethanol mill.Type: ApplicationFiled: January 8, 2016Publication date: December 28, 2017Applicant: Croda, Inc.Inventors: Min Ma Wang, Craig Michael Sungail, Xin Chen
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Publication number: 20170369816Abstract: Laundry detergents and their use for cold-water cleaning are disclosed. The detergents comprise a lipase and a mid-chain headgroup surfactant or an alkylene-bridged surfactant. The mid-chain headgroup surfactants have a C14-C30 alkyl chain and a polar group bonded to a central zone carbon of the C14-C30 alkyl chain. The alkylene-bridged surfactants comprise a C12-C18 alkyl chain, a polar group, and a C1-C2 alkylene group bonded to the polar group and a central zone carbon of the C12-C18 alkyl chain. Surprisingly, when combined with lipases, detergents formulated with the mid-chain headgroup or alkylene-bridged surfactants effectively liquefy greasy soils at low temperature and provide outstanding cold-water performance in removing greasy stains such as bacon grease, butter, cooked beef fat, or beef tallow from soiled articles.Type: ApplicationFiled: December 29, 2015Publication date: December 28, 2017Inventors: Brian Holland, Randal Bernhardt, Branko Sajic
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Publication number: 20170369817Abstract: The need for a liquid hard surface cleaning composition which provides improved grease removal and low suds is met using a combination of alkyl ethoxylated nonionic surfactant; an anionic surfactant selected from the group consisting of: an alkyl sulphate, a sulphonic acid or sulphonate surfactant, and mixtures thereof; and a co-surfactant in specific ratios.Type: ApplicationFiled: June 23, 2017Publication date: December 28, 2017Inventor: Geert Andre DELEERSNYDER
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Publication number: 20170369818Abstract: A liquid laundry detergent composition capable of suspending particles and insoluble materials while remaining readily pourable. The composition is stable over long periods of time. In one aspect, the liquid laundry detergent comprises in an aqueous medium: a) at least one nonethoxylated anionic surfactant; b) at least one ethoxylated anionic surfactant; c) at least one nonionic fatty alcohol ethoxylate surfactant; d) an optional surfactant selected from a nonionic surfactant other than c), a cationic surfactant, fatty acid salt surfactant, an ampholytic surfactant, and mixtures thereof; and e) a nonionic, amphiphilic, emulsion polymer that is crosslinked with an amphiphilic crosslinking agent.Type: ApplicationFiled: December 21, 2015Publication date: December 28, 2017Inventors: Jung Hyun Park, Francine I. Shuster, Sinan Li
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Publication number: 20170369819Abstract: Aminocarboxylate builders having 1 to 3 amino groups and 2 to 6 carboxylic acid groups improve blood soil removal, particularly from fabrics. Improved removal of body soils from fabrics is achieved by washing the fabric in a first wash liquor comprising one or more carboxylate builders, followed by a second wash in a wash liquor comprising surfactant.Type: ApplicationFiled: June 23, 2017Publication date: December 28, 2017Inventors: Francesco DE BUZZACCARINI, Xinbei SONG, William Mario Laurent VERSTRAETEN
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Publication number: 20170369820Abstract: A cleaning composition comprising: a. At least one alkanolamine b. At least one mineral acid c. At least one salt of a hydroxycarboxylic acid d. At least one protease enzyme; wherein said composition contains no surfactant.Type: ApplicationFiled: January 21, 2016Publication date: December 28, 2017Applicant: Whiteley Corporation Pty. Ltd.Inventors: Trevor Owen Glasbey, Nicolas Alan Roberts, Christopher David Hoffman, Phillip John Morgan
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Publication number: 20170369821Abstract: The present disclosure relates to a cleaning composition for removing an oxide including one selected from an organic acid, an inorganic acid, and any combination thereof; one selected from an organic salt, an inorganic salt, and any combination thereof; an oxidizing agent; a surfactant; and water, and a method of cleaning using the cleaning composition.Type: ApplicationFiled: June 23, 2017Publication date: December 28, 2017Inventors: Sungsoon Im, Kyuhwan Hwang, Youngmin Moon, Minho Moon, Inho Kong, Changsub Kim, Hotae Kim, Jaehwan Jin, Donguk Hwang
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Publication number: 20170369822Abstract: The present disclosure relates to water-soluble unit dose articles made from a combination of chemically different water-soluble films and optionally containing compositions that are at least partially enclosed by the water-soluble films in at least one compartment.Type: ApplicationFiled: June 12, 2017Publication date: December 28, 2017Inventors: Philip Frank Souter, Robby Renilde Francois Keuleers, Regine Labeque, Florence Catherine Courchay, Marc Rene Bert Renmans, David M. Lee, Steven G. Friedrich, Lee K. Yeung, Shinsuke Nii
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Publication number: 20170369823Abstract: The present disclosure relates to pouches made from a combination of chemically different water-soluble films and optionally containing a composition (e.g. a household care composition or non-household care composition) that is at least partially enclosed by the water-soluble films in at least one compartment.Type: ApplicationFiled: June 12, 2017Publication date: December 28, 2017Inventors: Philip Frank Souter, Robby Renilde Francois Keuleers, Regine Labeque, Florence Catherine Courchay, Marc Rene Bert Renmans, David M. Lee, Steven G. Friedrich, Lee K. Yeung, Shinsuke Nii
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Publication number: 20170369824Abstract: A portioned washing or cleaning agent in a container made of water-soluble material comprising at least two compartments which are separated from each other, wherein in at least one compartment a liquid washing or cleaning agent and in at least one further compartment, different herefrom, a powdery washing or cleaning agent is located which comprises core shell microcapsules in the form of microcapsule granulate, wherein the microcapsules comprise at least one additive in the core.Type: ApplicationFiled: September 6, 2017Publication date: December 28, 2017Applicant: Henkel AG & Co. KGaAInventors: Matthias Sunder, Frank Meier, Mario Sturm
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Publication number: 20170369825Abstract: A container assembly (10) for aging a liquid (14) includes: a container (12) that retains the liquid (14) being aged, the container (12) including a container aperture (24); and an oxygenator (16) that is positioned adjacent to the container aperture (24), the oxygenator (16) including a porous oxygenator membrane (38B) that allows for the flow of air into the container (12) through the oxygenator membrane (38B) and the container aperture (24).Type: ApplicationFiled: December 23, 2015Publication date: December 28, 2017Inventor: Jonathan William Roleder
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Publication number: 20170369826Abstract: A lab-on-chip type system, capable of identifying antibiotic sensitivity at the point of care of patients, especially in rural areas, clinics, hospitals that do not have care 24/7, hospitals with low level of equipment, among others, from the extraction of a sample, comprising a micro device or medical base device and a dispenser, wherein said micro device comprises a plurality of microwells, arranged in a circular fashion on one of the faces of the micro device, and wherein the micro-dispenser comprises a central plunger for taking and supplying the sample, a chamber for storage and distribution of the sample and a plurality of microdispensers arranged in a circular manner through which the sample is introduced into the microwells of the micro device.Type: ApplicationFiled: January 6, 2015Publication date: December 28, 2017Inventors: Sara DROGUETT BIZET, Mario SOTO AGUILERA
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Publication number: 20170369827Abstract: A system and method for printing cells in a medium. A multi-dimensional printer, stably constructed of low-mass parts, can include a computer numerically controlled system that can enable motors driving delivery systems. The motors can include encoders that can enable achieving arbitrary resolution. The motors can drive ballscrews to enable linear motion of delivery systems, and the delivery systems can enable printing of a biological material in a pre-selected pattern in a petri dish. The petri dish can accommodate a medium such as a gel, and can further accommodate a vision system that can detect actual position and deflection of the delivery system needle. The printer can accommodate multiple delivery systems and therefore multiple needles of various sizes.Type: ApplicationFiled: July 12, 2017Publication date: December 28, 2017Inventors: Christopher C. Langenfeld, David D. B. Cannan, Dirk A. van der Merwe, Jonathan Parker, John C. Anastasiou, Michael C. Tilley
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Publication number: 20170369828Abstract: A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.Type: ApplicationFiled: June 22, 2017Publication date: December 28, 2017Inventors: Michael MIETZNER, Rajesh BERI, Edward GUNDERSON
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Publication number: 20170369829Abstract: Provided herein are methods for culturing patient-derived tumor cell spheroids in a three-dimensional microfluidic device. The method comprises mincing primary tumor sample in a medium supplemented with serum; treating the minced primary tumor sample with a composition comprising an enzyme; collecting tumor spheroids having a diameter of 10 ?m to 500 ?m from the enzyme treated sample; suspending the tumor spheroids in biocompatible gel; and culturing the tumor spheroids in a three dimensional microfluidic device. Methods for identifying an agent for treating cancer and microfluidic devices that allow for the simultaneous exposure of the cultured patient-derived primary tumor cell spheroids to a treatment of choice and to control treatment are also provided.Type: ApplicationFiled: January 7, 2016Publication date: December 28, 2017Applicant: Dana-Farber Cancer Institute, Inc.Inventors: David Barbie, Amir Aref, Thanh Barbie, Russell W. Jenkins, Kwok-kin Wong
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Publication number: 20170369830Abstract: A cell culture method is a cell culture method for arranging cultured cells in a culture dish and continuously culturing the cultured cells by supplying a liquid required to grow or maintain the cultured cells to the culture dish and discharging the liquid from the culture dish. The cell culture method includes: providing a supply port of the liquid at one end of the culture dish and providing a discharge port of the liquid at other end of the culture dish so as to sandwich the cultured cells between the supply port and the discharge port, and discharging the liquid while supplying the liquid to the culture dish so that a moving linear velocity of the liquid from the supply port toward the discharge port is less than a maximum velocity at which shear stress is not applied to the cultured cells.Type: ApplicationFiled: December 10, 2015Publication date: December 28, 2017Inventors: Jun SUZUKI, Tadataka KAMIYAMA, Atsuhito OKONOGI, Toru MATSUME
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Publication number: 20170369831Abstract: A system and process for enhancing sensory attributes of a beverage product are described. According to one embodiment, the process comprises providing a consumable beverage. A sonication process is applied to the consumable beverage utilizing a sonication unit. Chemical reactions in the consumable beverage are catalyzed to modify a sensory attribute of the consumable beverage.Type: ApplicationFiled: June 23, 2017Publication date: December 28, 2017Applicant: E.& J. Gallo WineryInventors: Ajwinder Dhesi, Rachel Dokich, Sameen Kiayei, Raley Lee, Dharma Bangalore, Dhruba Das, David Warter, Ravi Ponangi, Richard Ntuli
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Publication number: 20170369832Abstract: A heating assembly for a bioreactor is disclosed. The heating assembly includes a holder having a plurality of segments coupled to each other to define a unitary structure and a heating component coupled to at least one segment of the plurality of segments. The unitary structure includes a top end, a bottom end, and a side wall. The side wall extends between the top end and the bottom end and along a circumferential direction of the heating assembly to define a cavity. At least a portion of the unitary structure has a gradually varied perimeter along a direction perpendicular to a plane which intersects the side wall and is parallel to the top end and the bottom end.Type: ApplicationFiled: June 27, 2016Publication date: December 28, 2017Inventors: Ying Mao, Weston Blaine Griffin, Younkoo Jeong
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Publication number: 20170369833Abstract: A bottle includes a body, a cap mounted to a cap neck of the body. The cap has an outer peripheral portion which is provided with a protrusion. Around the cap, there is provided a position indicator indicating whether the cap is at a correctly closed position, based on the positional relationship between the protrusion and the position indicator.Type: ApplicationFiled: June 27, 2017Publication date: December 28, 2017Applicants: DENSO WAVE INCORPORATED, ANIMAL STEM CELLInventors: Koji KAMIYA, Wataru SAITO, Kazuhiro NAGAIKE
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Publication number: 20170369834Abstract: The invention pertains to compositions for preserving biological material or active molecules, particularly microorganisms, and their uses.Type: ApplicationFiled: February 6, 2017Publication date: December 28, 2017Inventors: CHRISTOPHE HOLLARD, David FETT, Lars PETERSEN
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Publication number: 20170369835Abstract: The present invention relates to a method for degrading DNA in a sample obtained by microbial fermentation or bio-transformation, comprising treating the sample with a combination of increased temperature and low pH. It also relates to a method for releasing DNA from a microbial cell, comprising incubating the microbial cell at a temperature of 45° C. to 55° C. for two to ten hours. Finally, the present invention provides a method for producing a product, comprising a step of releasing DNA from a microbial cell and degrading said DNA.Type: ApplicationFiled: December 9, 2015Publication date: December 28, 2017Inventors: Birgit HOFF, Stefan HAEFNER, Weol Kyu JEONG, Edzard SCHOLTEN
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Publication number: 20170369836Abstract: The present invention discloses a serum-free medium for full suspension culture of MDCK cells and a preparation method of the serum-free medium. The serum-free medium for full suspension culture of the MDCK cells comprises basic metabolic nutrients, nucleotide, vitamins, inorganic salts, a shear force protective agent, a cell clustering resisting agent, a pH buffer agent, a pH indicator, an influenza virus proliferation accelerant and other additives. The preparation method of the serum-free medium for the full suspension culture of the MDCK cells comprises the following steps: 1) preparing a mixed solution: dissolving and mixing raw materials; and 2) regulating pH: regulating the pH of the mixed solution to 6.3 to 6.7, and setting a constant volume to obtain the serum-free medium for the full suspension culture of the MDCK cells.Type: ApplicationFiled: June 11, 2017Publication date: December 28, 2017Inventors: RUIAI CHEN, Hanzhang Lai, Wensong Tan, Xuanzi Zhan, Xuping Liu, Kangcong MAI, Weilan Pan, Xiaofen Wang, Huajian Chen, Peijun Chen, Jiahua Xu, Qin Tang, Wenyan Zhang, Yan Gao
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Publication number: 20170369837Abstract: The invention provides stable feed media containing pyruvate and methods for stabilizing feed media by adding pyruvate. The invention further provides methods for producing proteins using such media and proteins produced through the use of such methods.Type: ApplicationFiled: August 8, 2017Publication date: December 28, 2017Applicant: AMGEN INC.Inventors: Arvia Eleanor MORRIS, Aurora Villegas VIAJE, Erika PINEDA
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Publication number: 20170369838Abstract: The invention relates to a long term cell culturing method and a cell culturing apparatus and kit that employ a porous polyimide film. The invention further relates to a cell cryopreservation method and kit employing the porous polyimide film.Type: ApplicationFiled: January 26, 2016Publication date: December 28, 2017Inventors: Masahiko HAGIHARA, Motohisa SHIMIZU, Yukinori WADA
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Publication number: 20170369839Abstract: Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from humans lack reproducibility. Thus, the methods and compositions described herein are advantageous over the present state of knowledge in the art and permit the generation of human lung progenitor cells for treatment, tissue engineering, and screening assays.Type: ApplicationFiled: June 28, 2017Publication date: December 28, 2017Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Jayaraj Rajagopal, Hongmei Mou
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Publication number: 20170369840Abstract: Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.Type: ApplicationFiled: July 17, 2017Publication date: December 28, 2017Inventors: Marius Wernig, Thomas C. Sudhof, Thomas Vierbuchen, Austin Ostermeier, Zhiping Pang
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Publication number: 20170369841Abstract: Provided is a method for increasing the proportion of memory T cells in a T cell population, said method comprising a step of adding a modulator for the retinoid metabolic pathway and/or a modulator for the retinoic acid signaling system to the T cell population.Type: ApplicationFiled: December 22, 2015Publication date: December 28, 2017Applicant: International Institute of Cancer Immunology, Inc.Inventors: Haruo SUGIYAMA, Fumihiro FUJIKI
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Publication number: 20170369842Abstract: The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same and kits comprising the same.Type: ApplicationFiled: February 6, 2017Publication date: December 28, 2017Inventors: Suyi Tseng, Anish Sen Majumdar, Kevin Nishimoto, Anita Reddy, Jane S. Lebkowski
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Publication number: 20170369843Abstract: Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.Type: ApplicationFiled: March 29, 2017Publication date: December 28, 2017Inventors: Avak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
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Publication number: 20170369844Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: Terumo BCT, Inc.Inventors: James R. LADTKOW, Geoffrey M. UHL, Jeremy P. KOLENBRANDER, Briden Ray STANTON
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Publication number: 20170369845Abstract: Provided herein are methods for the isolation of platelets, for example, isolation of platelets from umbilical cord blood. In certain embodiments, presented herein are methods for preparation of platelet rich plasma. In one aspect, provided herein are methods for isolation of platelets from blood. In certain embodiments, presented herein are methods for isolation of platelets from cord blood, e.g., human cord blood. The isolated platelets can be used for a variety of applications, including, for example, methods of wound healing, organ repair and/or regeneration, and/or tissue repair and/or regeneration, in either autologous or allogenic settings.Type: ApplicationFiled: December 30, 2015Publication date: December 28, 2017Applicant: ANTHROGENESIS CORPORATIONInventor: Manoochehr KHORSHIDI
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Publication number: 20170369846Abstract: An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for producing high-purity cardiomyocytes and a kit used therefor. The present invention provides a method for sorting cardiomyocytes, comprising a step of introducing miRNA-responsive mRNA into a cell group, wherein the miRNA-responsive mRNA consists of a sequence comprising the following (i) and (ii): (i) a nucleic acid specifically recognized by miRNA specifically expressed in cardiomyocytes, and (ii) a nucleic acid corresponding to the coding region of a gene, wherein translation of (ii) the nucleic acid corresponding to the coding region of a gene into protein is regulated by the nucleic acid sequence in (i) above, thereby achieving the aforementioned objects.Type: ApplicationFiled: March 20, 2015Publication date: December 28, 2017Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
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Publication number: 20170369847Abstract: Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.Type: ApplicationFiled: January 15, 2016Publication date: December 28, 2017Inventors: Ying Mei, Tan Yu, Dylan Richards, Donald R. Menick, Bozhi Tian