Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.

Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

Abstract: The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.

Abstract: The invention relates to short RVG derived peptides for use in delivering therapeutic agents across the blood brain barrier and to target cells, for example those cells in the central nervous system. The invention provides method and compositions to treat diseases, such as neurodegenerative diseases, with therapeutic agents associated with targeting peptides.

Abstract: In certain embodiments, the present disclosure provides compositions and methods for treating Forbes-Cori Disease.

Abstract: The present invention provides compositions and methods useful for delivering agents to target cells or tissues, for example nerve cells and other cells in the central nervous system. The compositions and methods are useful for delivering agents across the blood-brain barrier. The present invention also provides methods of using the compositions provided by the present invention to deliver agents, for example therapeutic agents for the treatment of neurologically related disorders.

Abstract: The present invention relates to a complex that can be injected into the body to hone in on target cells to deliver molecules. In one embodiment, the invention provides a drug delivery system that includes components that self-assemble into one targeted conjugate. In another embodiment, the invention includes a targeted carrier protein and a nucleic acid sequence non-covalently linked to one or more drugs.

Abstract: The present invention relates to a composition comprising at least two different albumin-based drug delivery systems, as well as to a pharmaceutical composition comprising said composition.

Abstract: The present invention relates to antibody-drug conjugates (ADCs) and a method for improving the safety profile of the same, comprising linking an antibody molecule to a drug in order to obtain said ADC, wherein said antibody molecule is obtainable from a host cell selected to produce an antibody molecule composition having specific glycosylation

Abstract: This invention relates to treatment of acute lymphoblastic leukemia.

Abstract: The present invention relates to a conjugate comprising an anti-HER-2 binding protein site-specifically conjugated to at least one maytansinoid toxic payload by means of sortase enzyme mediated conjugation.

Abstract: Provided herein are theranostic compositions comprising a Janus nanoparticle-coated microbubble that are useful for imaging (e.g., MRI, or ultrasound) and for delivering a therapeutic or bioactive agent (e.g., nucleic acid(s), drugs, etc), among other uses.

Abstract: The invention in the various aspects provides nanogel compositions that are safe for topical, local, and/or systemic delivery, and which can be targeted to select tissues or cells, including pathogens. In some embodiments, conjugation of antibiotics to the nanogel surface, and in particular antibiotics that disrupt outer membranes of Gram negative bacteria or antibiotics that inhibit cell wall synthesis, provide for highly effective targeting and killing of bacterial pathogens, including drug-resistant bacteria.

Abstract: Disclosed are novel gene therapy constructs containing both HEXA and HEXB genes to treat GM2 gangliosidoses, including Sandhoff disease and Tay-Sach's disease. Also described are co-treatments using chaperone and anti-inflammatory agents to enhance the effects of gene therapy.

Abstract: The present disclosure relates to the delivery of polynucleotides and/or oligonucleotides using silica delivery platforms, e.g., silica carriers or protocells. In particular, in the present disclosure, polynucleotides in the form of plasmids expressing siRNA may be administered as cargo in the silica delivery platform to a patient or subject to inhibit and/or treat cancer in a patient. In one aspect, the silica delivery platform that have been charged with cargo comprising plasmid DNA (in particular, CRISPR ds plasmid DNA) which expresses siRNA, shRNA, mRNA and other RNA which may be used to administer these plasmids to patients in order to effect inhibition of cancer cells (especially including apoptosis of those cancer cells) and effective and/or prophylaxis of cancer, as well as numerous pathogens, including viruses, bacteria, fungi, and/or other disease states and/or conditions. In another aspect, the silica delivery platform comprises a biological package (e.g.

Abstract: The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. In a specific embodiment, the present invention provides an extracellular vesicle isolated from a cell comprising one or more microRNAs (miRNAs) that have been loaded ex vivo into the vesicle so that the miRNAs are present in a higher concentration than when measured in the same extracellular vesicle isolated directly from the cell. In another embodiment, the present invention provides a method for treating cholangiocarcinoma in a subject comprising the step of administering to the subject a plurality of exosomes comprising miR-195.

Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

Abstract: The present invention relates to dual activation of Akt/NF?B pathway by DMA (5-(4-methylpiperazin-1-yl)-2-[2?-(3,4-dimethoxyphenyl)-5?-benzimidazolyl]benzimidazole) to render radioprotection both in mammalian cells and in Balb/c mice. Further it selectively protects normal cells overs tumor tissues against lethal total body irradiation (TBI) and there was no activation of Akt/NF?B pathway by DMA in response to radiation in tumor tissues. A single dose of DMA before TBI protect mice from GI and HP acute radiation syndrome (ARS) and offered radioprotection through oral, i.v., i.p., and s.c route of administration. The half life of DMA in plasma is 3.5 h at oral dose and 90% clearance was observed in 16 h. DMA accumulates in high concentration in intestine, liver, kidney and spleen tissues, justifying the observed radioprotection to normal tissue even at single dose.

Abstract: The present invention relates to an imaging composition for imaging the urinary pathways, which comprises particles each independently comprising (a) a phospholipid, wherein a near infrared (NIR) fluorescent probe is non-covalently linked to said particle; or (b) an inclusion complex of said NIR fluorescent probe and either an hydroxyalkyl- or sulphoalkylether-cyclodextrin; and to a method of use.

Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.

Abstract: Provided are compositions for rapid detection of lymph nodes. The compositions include magnetic particles, such as iron oxide, and a solute present in an amount that results in a hypoosomotic solution. Methods for detecting lymph nodes also are provided.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

Abstract: The present invention relates to a method for the synthesis of a radioactive agent composition comprising at least a purification step carried out in the presence of an antioxidant, to the composition obtained by this method comprising radioactive agent and excipient, and to the method for preventing radiolysis of radioactive agent composition comprising the synthesis of said radioactive agent according to the method of the invention.

Abstract: The present invention relates to radiopharmaceutical compositions comprising the mother nuclide 224Ra, its daughter nuclide 212Pb, and a complexing agent that complexes with the daughter nuclide. The use of targeted chelate scavengers for 224Ra daughter nuclide opens up the possibility for using 224Ra based solutions for medial treatments.

Abstract: A tongue cleaner that can be used by an operator or an individual that is capable of removing debris and killing bacteria from the tongue. The improvement comprises of a UV light source located on the tongue cleaner scraper head that would let UV light shine directly onto the tongue, as it is stroked against the tongue, it would kill the germs and bacteria.

Abstract: When using a Prep Pad that contains a solution soaked with alcohol, adhesive or patch remover, or any other kind of antibacterial agent, the act of operating it while trivial for one time use can quickly become inefficient, mundane and time consuming. The invention packs multiple, but single use encapsulated Pellets inside a cylindrical refill apparatus. The Pellet is made of soft material and it may be soaked or un-soaked. The refill apparatus is then inserted into a cylindrical pen like structure that automatically peels the Pellet when operated. The result is that in a few pen like clicks, an operator, using a single hand, can quickly get ready to cleanse or apply a Pellet onto a surface. An operator can easily store capacity for multiple applications in a pen pocket. The single hand use, quickness to readiness and compact easy storage makes the invention ideal alternative to a Prep Pad like use.

Abstract: When using a Prep Pad that contains a solution soaked with alcohol, adhesive or patch remover, or any other kind of antibacterial agent, the act of operating it while trivial for one time use can quickly become inefficient, mundane and time consuming. The invention packs multiple, but single use encapsulated Pellets inside a cylindrical refill apparatus. The Pellet is made of soft material and it may be soaked or un-soaked. The refill apparatus is then inserted into a cylindrical pen like structure that automatically peels the Pellet when operated. The result is that in a few pen like clicks, an operator, using a single hand, can quickly get ready to cleanse or apply a Pellet onto a surface. An operator can easily store capacity for multiple applications in a pen pocket. The single hand use, quickness to readiness and compact easy storage makes the invention ideal alternative to a Prep Pad like use.

Abstract: A solution for controlling mildew in a cultivated area is described. The solution can include a set of ultraviolet sources that are configured to emit ultraviolet radiation in an ultraviolet range of approximately 260 nanometers to approximately 310 nanometers to harm mildew present on a plant or ground surface. A set of sensors can be utilized to acquire plant data for at least one plant surface of a plant, which can be processed to determine a presence of mildew on the at least one plant surface. Additional features can be included to further affect the growth environment for the plant. A feedback process can be implemented to improve one or more aspects of the growth environment.

Abstract: Alkaline in-use solutions that may be used to disinfect and/or sanitize hard surfaces and which may act as anti-biofilm agents, comprise a disinfectant/sanitizer cleaner solution and an activator solution that are mixed together to form the alkaline in-use solutions. Disinfectant/sanitizer cleaner solution may comprise quaternary ammonium compound and hydrogen peroxide. Activator solution may comprise alkaline buffering agent, chelating agent and soluble silicon dioxide.

Abstract: A mist generator improves sterility of blowers having controlled forced air for patient warmers and lifters. The mist generator has a main body including a top wall with an opening, that traverses into a chamber adapted to receive a disinfectant, side walls and a bottom wall. The main body further includes an inlet duct adapted for attachment to a first hose which, in turn, is adapted for attachment to an output opening of the blower for delivery into the chamber of forced air carrying misted disinfectant. The main body also includes an output duct adapted for attachment to a second hose which, in turn, is adapted for attachment to an inlet opening of the blower for delivery of disinfectant misted air through internal components of the blower. The mist generator improves sterility of the blower, thereby mitigating microbial contamination of patient warmers and lifters, and hospital environments.

Abstract: Disclosed embodiments include a tray configured for holding various sterilization targets. The tray may include a perforated floor member connected to a plurality of vertically oriented walls, which may also be perforated. Together, the floor member and walls define an internal cavity that includes at least one wire support for removably holding at least one sterilization target, such as a medical instrument and/or implant or components thereof, within the internal cavity. Each wire support may include two end inserts and a middle portion, the two inserts secured via connection means to one or more walls of the tray. The connection means may comprise mounting fixtures that further include a plurality of receiving slots or holes each configured to receive an insert. The wire supports may increase sterilant flow and circulation, thereby improving sterilization of instruments and/or implants held within the tray disclosed herein.

Abstract: A sterilizer comprises a sterilization chamber (1) with a test device (2) for testing the effectiveness of a sterilization process. The test device (2), in turn, comprises a test element (3) with a sensor (4) for measuring at least one parameter, and cooling mechanism (5) for cooling the test element (3).

Abstract: An agent for removing malodor from a painting booth includes a volatile organic compound (VOC) degrading microorganism and a volatile fatty acid (VFA) degrading microorganism. The VOC degrading microorganism is configured to degrade VOC. The VFA degrading microorganism is configured to degrade VFA generated when the VOC is degraded.A method of removing malodor is also disclosed.

Abstract: A freshening composition is provided. The composition includes at least one particle, and an aqueous carrier. The composition includes a polysaccharide system having a first polysaccharide and a second polysaccharide. The first polysaccharide is xanthan gum and the second polysaccharide is selected from the group consisting of konjac gum, locust bean gum, and combinations thereof. The composition may include an unencapsulated perfume.

Abstract: A freshening composition is provided. The freshening composition includes a plurality of particles, a structurant system, and an aqueous carrier. The composition has a spray shear viscosity, as measured according to the SPRAY SHEAR VISCOSITY TEST METHOD described herein, of less than about 0.025 Pa-s. The composition has a creep recovery ratio of at least about 0.1, as measured according to the CREEP RECOVERY RATIO TEST METHOD described herein, or a yield stress of greater than 0 Pa and less than 1.0 Pa, as measured by the YIELD STRESS TEST METHOD described herein.

Abstract: A method of freshening the air or a surface is provided. The method comprises the steps of: providing a freshening composition, the freshening composition comprising a plurality of particles and a structurant system; and spraying the freshening composition in the form of a plurality of spray droplets, wherein the plurality of spray droplets have: a normalized D(90) value of less than 2.5, when sprayed from a TS800 sprayer according to the SPRAY D(90) NORMALIZED AND SPRAY D(4,3) NORMALIZED TEST METHOD described herein, a residue value of less than about 8 at 5 sprays, according to the RESIDUE TEST METHOD described herein, and a phase stability grade of 1 or 2, according to the PHASE STABILITY GRADE AT 25° C. TEST METHOD described herein.

Abstract: [Object] It is possible to efficiently perfume using a relatively small amount of fragrance material while an increase in size of a perfuming device is minimized. [Solution] Provided is a cartridge for a perfuming device, including: a main body part; an air flow channel that is provided in the main body part and has both ends that are open; and a fragrance material held in at least a part of an inner surface of the air flow channel.

Abstract: A freshener device includes a clip, a carrier, and a carrier retainer. The carrier is provided with odor emitting substances, odor eliminating substances and/or incest repellent. The carrier retainer secures the carrier to the clip, and the clip may be used to secure the device to an ancillary object so as to expose the carrier for controlling odor within a region of space near the ancillary object. Some embodiments enable removably securing the device to at least one air-directional controller exhaust vent louver of a vehicle air conditioning unit to control odor within the passenger compartment of the vehicle. Other embodiments enable interchangeable and replaceable components to provide various utilitarian and aesthetic features.

Abstract: Polymeric films, articles and method of making films comprising the steps of forming a film from a polymeric composition comprising polyethylene, polypropylene, or mixtures thereof, wherein the film has a basis weight of from about 5 gsm to about 50 gsm; applying a substance to from about 10% to about 75% of the surface area of the film to form a plurality of printed areas; and, hardening the substance, whereupon the substance changes in size to produce a contoured film.

Abstract: Provided are materials including cell proliferation properties. The materials may include a polymer having incorporated therein a synergistic combination of at least two metal oxide powders, including a mixed oxidation state oxide of a first metal and a single oxidation state oxide of a second metal. The mixed oxidation state oxide may constitute from about 25% wt. to about 75% wt. of the total weight of the synergistic combination of the at least two metal oxide powders. The powders may be incorporated substantially uniformly within the polymer. The ions of the metal powders may be in ionic contact upon exposure of the material to moisture. Further provided are methods for the preparation of the materials and uses thereof, including in skin regeneration processes and cosmetic applications.

Abstract: The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.

Abstract: Embodiments of the present disclosure are directed to perforated polymer films and methods of making the same. In some embodiments, the films are for use with implantable medical devices. In one embodiment there is a flexible body including a polymer film having a first surface and an opposing second surface, the film having a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by a one of the plurality of raised lips. In one embodiment, the film comprises a single layer, and in another embodiment, the film can comprise a plurality of layers. In certain embodiments, the film can comprise an adhesive layer. In another embodiment, one or more of the layers may be a drug containing layer and/or a rate controlling layer for drug release.

Abstract: An occlusive device and a method of embolizing or occluding a bodily lumen by injecting or otherwise implanting the occlusive device are described. The device includes a polymer or polymer composition and a carbon-based material or nanomaterial such as graphene. The device may be used for sterilizing a human or animal by implanting the device into the vas deferens, fallopian tubes, or uterus, but may also be used to occlude any other bodily ducts, interstitial space, or organs.

Abstract: The present invention relates to a crystallized glass ceramic comprising 30 wt % to 40 wt % of each of CaSiO3, Ca10(PO4)6(OH)2, and Ca2Mg(Si2O7); a crystallized glass ceramic composition comprising CaSiO3, Ca10(PO4)6(OH)2, and Ca2Mg(Si2O7) in a predetermined weight ratio; a bone graft material comprising the glass ceramic; and an intervertebral spacer or medical device for replacement of bone tissue, which is manufactured using the bone graft material.

Abstract: Biocompatible and implantable in the human body plastic material, for the obtainment of a device that can be implanted in the human body or a spacer device in order to treat a bone or a joint location, including an acrylic resin or polyethylene (PE) or low density polyethylene or high density polyethylene or ultra-high molecular weight polyethylene (UHMWPE) or polypropylene or polyamide or polyetheretherketone (PEEK) or a thermosetting resin or a mixture of the same, wherein the material can be molded and includes at least one pharmaceutical or medical substance; device implantable in the human body or spacer device for treating a bone or a joint location, obtained by the material above and method for manufacturing the material according to the present invention.

Abstract: A combined fully organic high molecular material artificial knee joint, comprising a femur condyle (2), a tibia holder (4) and a tibia liner (3), the femur condyle (2) and the tibia holder (4) being formed by polyether ether ketone (PEEK) or derivatives thereof, and the tibia liner (3) being formed by ultra-high molecular weight polyethylene (UHMWPE). The tibia holder (4) comprises a platform (6) and a stable wing positioning portion (5) vertical thereto; upper and lower ends of the tibia liner (3) are jointed with the femur condyle (2) and the platform (6) respectively; the femur condyle (2) buffers a slide surface of the tibia liner (3); and the tibia holder (4) can finely move relative to a fixed surface of the tibia liner (3), and buffering of the femur condyle (2) against the slide surface of the tibia liner (3) matches fine movement of the tibia holder (4) relative to the tibia liner (3).

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: The invention is directed to biocompatible composite materials for medical applications such as tissue regeneration. In particular, the present invention is directed to biocompatible composite materials that may be used for the treatment of lost bone or bone defects. According to the invention there is provided an anhydrous biocompatible composite material comprising a biodegradable polymeric material and a granular synthetic material, wherein the polymeric material essentially consists of at least one block copolymer that comprises at least one hydrophilic block and at least one hydrophobic block.

Abstract: The invention features the use of a matrix consisting of low molecular weight components for use as a self-eliminating coating for implantable medical devices. The matrix coatings can be used to enhance biocompatibility and to control the local delivery of biologically active agents.