Abstract: The presently disclosed subject matter provides fragrance compositions and fragrance combinations that can stimulate the trigeminal system. The compositions and combinations of the presently disclosed subject matter can include both one or more trigeminal-stimulating compounds and one or more additional fragrance compounds. The trigeminal-stimulating compounds can include cooling, warming, and tingling compounds.

Abstract: A composition containing at least one isomeric alkoxynonenol, in particular, isomeric 8-alkoxy-4,8-dimethylnon-1-en-3-ol, in an amount effective to impart a fragrance to the composition. A fragrance composition containing at least one isomeric alkoxynonenol in an amount effective to impart a fragrance to the composition. A consumer product containing the fragrance composition having at least one isomeric alkoxynonenol in an amount effective to impart a fragrance to the composition. A method of imparting a fragrance to a consumer product by adding to the consumer product a fragrance composition containing at least one isomeric alkoxynonenol in an amount effective to impart a fragrance to the consumer product.

Abstract: The fragrance composition of Citrus flowers according to the present invention is produced by respectively adding jasmone and ?-caryophyllene to linalool, myrcene, nerolidol, methyl anthranilate or the like which have been analyzed to be aromatic components of the flowers of Citrus unshin and the flowers of Citrus natsudaidai by means of the SPME method, and by adding ?-terpinene to linalool, myrcene, geraniol, ?-ocimene or the like which have been analyzed to be aromatic components of the flowers of Citrus sudachi, and also adding ?-farnesene to ?-ocimene, 6-methyl-5-hepten-2-one, anthranilaldehyde, limonene, methyl anthranilate or the like which have been analyzed to be aromatic components of the flowers of Citrus japonica. The present invention makes it possible to provide a fragrance composition which is outstandingly palatable while reproducing the inherent aromas of Citrus unshin, Citrus natsudaidai, Citrus sudachi and Citrus japonica.

Abstract: A cleaning article including one or more cleaning agents such that the cleaning article exhibits improved mirror cleaning.

Abstract: Particulate solids with an average particle diameter X50,3 of 0.01 mm to 3 mm, containing a total quantity of 30 to 100 wt. %, based on the total weight, of at least one polyester, containing at least one structural unit of the formula (I) and at least one structural unit of the formula (II), in which a and c each represents a number from 1 to 200 independently of each other. R2, R5, and R6 each represents hydrogen or a C1-C18 n-alkyl group or a C3-C18 isoalkyl group independently of one another. R7 represents a linear or branched C1-C30 alkyl group or a linear or branched C2-C30 alkenyl group, a cycloalkyl group with 5 to 9 carbon atoms, a C6-C30 aryl group, or a C6-C30 arylalkyl group. The particulate solids can be suspended in liquid, water-containing surfactant compositions in a stable manner.

Abstract: The present invention concerns liquid laundry detergent formulations comprising a dye polymers comprising a polyethylene imine covalently bound to a reactive dye and the use of the dye polymers in liquid laundry compositions with specific surfactant mixtures.

Abstract: Microfibrillated cellulose, derived from vegetables or wood, can be used to provide a liquid fabric care composition which is easy to pour, is stable and deposits well onto treated fabric.

Abstract: The aim of the invention is to improve the primary detergent power of detergents and cleaning products, in particular with respect to soiling containing oil and/or grease. For this purpose, copolymers including ethylenically unsaturated carboxylic acid-derived sulfobetaine units and hydroxyalkyl(meth)acrylic acid esters are incorporated into the products.

Abstract: Rinse aid compositions, methods of use, and methods of making said composition are disclosed. The rinse aid compositions can be solid or liquid. The rinse aid compositions comprise a defoamer, a sheeting agent, and a terpolyer of of maleic, vinyl acetate, and ethyl acrylate. Preferred sheeting agents include one or more alcohol ethyoxylates. Preferred defoamer components include a polymer compound including one or more ethylene oxide groups. The solid rinse aid compositions are preferably substantially free of sulfate and sulfate-containing compounds.

Abstract: A phosphate-free automatic dishwashing cleaning composition including: i) a protease wherein the protease is a variant of a parent protease having the amino acid sequence of SEQ ID NO:1 and the variant protease has at least 90% identity with the amino acid sequence of SEQ ID NO:1 wherein the protease comprises at least one aspartic acid residue in the active site loop region from position 95 to 103 (BPN? numbering); and ii) greater than 5% of a crystal growth inhibitor, preferably hydroxyethylidine 1,1-diphosphonic acid (HEDP).

Abstract: A phosphate-free automatic dishwashing cleaning composition including: i) a protease wherein the protease is a variant of a parent protease having the amino acid sequence of SEQ ID NO:1 and the variant protease has at least 90% identity with the amino acid sequence of SEQ ID NO:1 wherein the protease includes at least one aspartic acid residue in the active site loop region from position 95 to 103 (BPN' numbering); and ii) from about 30% to about 50% by weight of the composition of an organic complexing agent.

Abstract: A phosphate-free automatic dishwashing cleaning composition including: i) a protease wherein the protease is a variant of a parent protease having the amino acid sequence of SEQ ID NO:1 and the variant protease has at least 90% identity with the amino acid sequence of SEQ ID NO:1 wherein the protease comprises at least one aspartic acid residue in the active site loop region from position 95 to 103 (BPN? numbering); and ii) more than 15% of organic complexing agent system comprising a weak complexing agent and a strong complexing agent in a weight ratio of from about 0.5:1 to about 2:1.

Abstract: A phosphate-free automatic dishwashing cleaning composition including a protease wherein the protease is a variant of a parent protease having the amino acid sequence of SEQ ID NO:1 and the variant protease has at least 90% identity with the amino acid sequence of SEQ ID NO:1 wherein the protease comprises at least one amino acid residue with a carboxylic acid side chain in the active site loop region from position 95 to 103 (BPN? numbering) with the proviso that the variant protease does not have 100% identity with SEQ ID NO:3, SEQ ID NO:4, or SEQ ID NO: 5.

Abstract: A phosphate-free automatic dishwashing cleaning composition including a protease wherein the protease is a variant of a parent protease having the amino acid sequence of SEQ ID NO:1 and the variant protease has at least 90% identity with the amino acid sequence of SEQ ID NO:1 wherein the protease includes at least one glutamic acid residue in the active site loop region from position 95 to 103 (BPN? numbering).

Abstract: Disclosed is a cleaning composition containing a metal-containing bleach catalyst, a carboxymethylcellulose (CMC) and further commonly used cleaning composition ingredients such as a builder, a surfactant, polymers/cobuilders, and an enzyme. Preferably, the cleaning composition does not contain a bleach activator such as tetraacetylethylenediamine (TAED). Preferably, the metal-containing bleach catalyst contained in the cleaning composition is a cobalt (Co) containing bleach catalyst or a manganese (Mn) containing bleach catalyst. In the cleaning composition, the carboxymethylcellulose is preferably present in an amount of at least 0.02% (w/w), preferably at least 0.05% (w/w) relative to total amount of the cleaning composition.

Abstract: The present invention concerns liquid laundry compositions with specific surfactant mixtures and dye polymers. The dye polymers comprise a polyethylene imine covalently bound to a reactive dye. The surfactant mixture comprises anionic and non-ionic surfactants, wherein the fraction of alkyl ether sulphate to total anionic surfactant is at least 0.5 and the alkyl ether sulphate has at least 2 EO.

Abstract: A multi-purpose cleaner system for providing a composition for cleaning at least one surface. The multi-purpose cleaner composition is all natural and cleans a variety of surfaces like flooring, glass, counter tops, porcelain, grout, and many more. At least one essential oil is included in the multi-purpose cleaner composition to provide aromatherapy benefits. The multi-purpose cleaner system is intended for continuous use in order to deliver healthier and aesthetically pleasing surfaces.

Abstract: A process for reblending a first liquid detergent composition into a second liquid detergent composition.

Abstract: Cleaning articles including a heat engine incorporated therein. The cleaning article may include a substrate (e.g., a non-woven wipe) including one or more layers. The heat engine may be in the wipe or pad, and includes a reactive metal oxide which upon contact with water, reacts to produce heat. The cleaning article may thus produce water vapor and/or steam upon activation of the heat engine. A venting structure may be provided adjacent to or surrounding the heat engine that includes an impermeable material (e.g., impermeable to water and/or air or other gas), which includes one or more vents through the impermeable material. The venting structure directs water vapor and/or steam to a desired face of the cleaning article, away from the user. A heat barrier layer may insulate a user's hand from the generated heat, and/or a handle may be attachable to the pad.

Abstract: Appliances (100) for preparing and dispensing beverages, such as beers, featuring a transparent window (110) that allows a user of the appliance to view the beverage in a chamber of the appliance as that beverage is being prepared are disclosed. The chamber in which the beverage is prepared can be either an integral part of the appliance or a disposable chamber that can be removed and replaced with a new disposable chamber after one or more servings of a beverage has been prepared in the disposable chamber. The appliances can have methods for cleaning the chamber, or the chamber can be self-cleaning. If the chamber for preparing the beverage is a disposable container, it may come with a concentrated beverage already prepackaged in the container, and the casing of the container can prevent oxygen and light from penetrating the container and affecting the concentrated beverage contained within.

Abstract: A method of making a sherry wine-like beverage includes combining water, ethanol and a plurality of flavor compounds in an amount sufficient to impart the flavor of a sherry wine without the need for fermentation and/or aging.

Abstract: The present invention provides beverages and pharmaceutical compositions containing a deuterated alcohol according to Formula 1, and provides methods for their manufacture and use. The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing.

Abstract: A method for producing a food product based on vinegar cream and cheese cream, comprises the steps of providing at least one vinegar cream and at least one cheese cream, mixing at least one vinegar cream with at least one cheese cream in respective predetermined amounts, so as to obtain a food product having the characteristics of stability with long periods of preservation as well as particularly unique and pleasant flavour.

Abstract: This invention relates to a sampling device comprising a shaft and a sample collection portion removably connected with the shaft, wherein the connection site between the shaft and the sample collection portion is weakened. The invention relates also to a combination of a sampling device comprising a shaft and a removable sample collection portion and a sample vessel configured to receive sample collection portion from the shaft.

Abstract: The method comprises an automated removal of cells and/or cell colonies from a cell culture whilst executing a first detection step for selecting cells and/or cell colonies with reference to corporeal and/or physical parameters and detecting position data and storing the detected position data of the selected cells and/or cell colonies in a position database. In order to be able to select special cells and/or cell colonies having special properties from the detected cells and/or cell colonies, at least one second detection step for detecting at least one further parameter of the cells and/or cell colonies is then executed, comparative data from the data of the first and second detection step are created, cells and/or cell colonies are selected with reference to the comparative data and the position data from the position database are transferred to a harvesting unit.

Abstract: The present invention provides a system and a method for the production of cells and/or cell products. The system comprises at least one cell culture unit comprising at least one bioreactor for culturing cells, at least one technical control unit for controlling a cell growth parameters, said technical control unit is at least fluidly connected to the cell culture unit, and at least one air treatment unit for treating ambient air, said air treatment unit is fluidly connected to the cell culture unit. The system is characterized in that the system is autonomous and the bioreactor total volume is at most 1000 L.

Abstract: Embodiments of this invention provide an apparatus that allows for the biodegrading of materials including food waste, food service paper products, wet waste, paper cardboard, landscape waste, and other organic solids using a prefabricated, multi-modal, portable, modular system that includes a series of bio-mimicry vessels in multiple mode deployment.

Abstract: There is provided viable Escherichia coli (E. coli) embedded in a matrix, wherein said matrix has a water activity (aw)?0.3, and wherein said matrix comprises a hydrocolloid-forming polysaccharide, a second polysaccharide which is different from the first polysaccharide, and a disaccharide which includes sucrose, trehalose, or a combination thereof. There is also provided methods of making same and use thereof.

Abstract: A method and system removes biological contaminants from an algal crop. A flow of an algal crop containing biological contaminants is provided to a hydrodynamic separator (HDS) system. The flow is controlled by a control mechanism, wherein the biological contaminants are concentrated into a first portion of the flow of the algal crop within the HDS system, based on the size of the biological contaminants, and the first portion contains a majority of the biological contaminants in the flow of the algal crop. A second portion of the flow contains a majority of algal in the flow of the algal crop. The flow of the algal crop is split by use of a bi-furcated output of the HDS system. The splitting is between the first portion containing the majority of the biological contaminants in the flow of the algal crop, and the second portion which contains the majority of the algal of the algal crop.

Abstract: The present invention provides a method for reducing the viscosity of a microorganism-containing suspension or concentrate and a method for obtaining a microorganism concentrate, wherein a monosaccharide and/or disaccharide and/or sugar alcohol is added to said microorganism-containing suspension or concentrate.

Abstract: One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.

Abstract: One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.

Abstract: One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.

Abstract: One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.

Abstract: This invention provides an Amycolatopsis sp. strain (zhp06), and a method of using the whole cell preparation of the strain for vanillin production. The strain was deposited in China Center for Type Culture Collection on Jul. 26, 2011 with the number of CCTCC NO: M 2011265. Under high concentrations of ferulic acid substrate, the vanillin production by this method can reach more than 10 g/L. The molar conversion rate of ferulic acid is more than 50% and the purity of vanillin is from 80% to 95%. The advantage of this invention includes: repeated use of biocatalyst cells, mild biotransformation condition, low environmental pollution, short production cycle, high product purity and simple purification procedure. It has a great potential for industrial applications.

Abstract: Provided herein is a culture medium for in-vitro cultivation of Mycobacterium leprae (M. Leprae) comprising: a) a solid phase comprising Lowenstein-Jensen medium, and b) a liquid phase comprising a stock solution of Middlebrook 7H9, Middlebrook Growth Supplement, thyroxine, glycerol and a mixture of an antifungal agents and antibiotics.

Abstract: Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and/or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and/or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.

Abstract: Methods are provided for the generation of mesodermal cell types and derivatives thereof. Also provided are methods for generating purified populations of mesodermal cell types and derivatives thereof. The instant disclosure also provides methods of screening for cellular responses of the generated mesodermal cell types and derivatives thereof. Also provide are methods for screening for organismal phenotypes induced by introduction of the generated mesodermal cell types and derivatives thereof. Treatment methods making use of the generated mesodermal cell types and derivatives thereof are also provided. The instant disclosure also provides systems, compositions, and kits for practicing the methods of the disclosure.

Abstract: Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.

Abstract: As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in TET2 leads to pro-inflammatory IL-1? signaling at multiple levels, including increased IL-1? transcription, increased NLRP3 inflammasome-mediated IL-1? secretion, and increased IL-1-Receptor 1-mediated IL-1? signaling. Accordingly, provided herein are compositions, methods, and assays for modulating TET2 mutation-mediated IL-1? (interleukin-1?) proinflammatory activity, particularly when caused by somatic mutations in TET2.

Abstract: The present invention provides human bone-marrow cells enriched with functional mitochondria, methods for their production, and therapeutic methods utilizing such cells.

Abstract: The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti CD4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts and uses. The invention further relates to the modification of antibodies reactive to the CD4 human leukocyte antigen to provide anti-CD4 antibodies that have a reduced number of potential T-cell epitopes but retain the ability to bind to CD4, such as to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains.

Abstract: The invention relates to the use of a laminin (LN) as a matrix for hepatic differentiation. The invention also relates to a method for inducing hepatic differentiation comprising the steps of: (i) providing a population of human pluripotent cells, (ii) culturing the population on a support coated with a laminin in a endoderm induction medium to produce a population of human DE cells, (iii) culturing said population of human DE cells on a support coated with a laminin in a hepatic induction medium to produce a population of human hepatoblasts-like cells, and (iv) optionally culturing said population of human hepatoblasts-like cells on a support coated with a laminin in a hepatic maturation medium to produce a population of human hepatocyte-like cells. The invention further relates to a population of human hepatoblasts-like cells or human fetal hepatocyte-like cells obtained by the method of the invention.

Abstract: The present invention describes a viral RNA expression plasmid and a method for obtaining viral particles based on said plasmids comprising transfecting animal cells with an expression vector or a set of expression vectors capable of expressing a nucleoprotein and RNA-dependent polymerase RNA; and transfecting the animal cell with an expression vector or a set of expression vectors with nucleotide sequences encoding recombinant RNA molecules.

Abstract: A method of preparing a vaccine for immunization against a herpes virus comprising the steps of one of deleting, substituting, or modifying a UL148 gene and interfering with or modifying an expression of the UL148 gene. Wherefore, it is an object of the present invention to overcome the above mentioned shortcomings and drawbacks associated with the prior art The inventors observed that less extensively passaged HCMV strains that retain expression of gH/gL/UL128-131 can efficiently infect epithelial and endothelial cells.

Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).

Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: The invention addresses the need for enzymes that can enhance the yield of fermentable sugar from the hydrolysis of lignocellulose biomass, for example sugar cane bagasse, barley straw and wheat straw, such that the use of this biomass can become economically viable. The invention provides methods for the hydrolysis of biomass using a laccase derived from Ganoderma lucidum. Further, the invention provides an enzyme composition comprising a laccase derived from Ganoderma lucidum which may be combined with one or more cellulases, and for its use in enhancing lignocellulose biomass hydrolysis.

Abstract: The present invention relates to an original and specific mixture of purified superoxide dismutases (SODs) of plant origin, characterised in that said mixture is essentially made up of three superoxide dismutases: a manganese superoxide dismutase, a copper and zinc superoxide dismutase and an iron superoxide dismutase provided in two isoforms, which can be obtained from an extract of the hybrid variety F1 of Cucumis melo MA 7950 or the cells thereof cultured in vitro or by transfer and expression of the genes of said SODs in prokaryotic or eukaryotic cells. The specific mixture according to the invention imparts to the compositions containing same a greater effectiveness in the treatment or prevention of diseases linked to inflammatory and/or oxidative stress, such as radiation-induced fibroses, cardiovascular diseases, obesity, atherosclerosis, labial herpes and myopathies, as well as in nutritional, pharmaceutical, veterinary or cosmetic uses.

Abstract: Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.