Patents Issued in February 22, 2018
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Publication number: 20180051211Abstract: The present invention describes composite materials presenting an optical, electrical or optoelectronic response to stimuli, respective production method and application as sensitive films for the detection or quantification of a variety of analytes and analyte patterns, including but not limited to volatile organic compounds (VOC), vapors and gases, biomolecules, microorganisms, viruses, cells, and particles, as well as differences of temperature, pressure and electromagnetic fields. The composite material contains a mixture of (i) at least one liquid crystal; (ii) at least one ionic liquid or molecules with surfactant properties; (iii) polymer(s), preferably with natural or synthetic origin; (iv) appropriate solvent(s); optionally (v) a stabilizing element, such as sorbitol; and (vi) an electrolyte, which can be dispensed when the sensitive film is used to obtain an exclusively optical response or when the ionic liquid(s) or surfactant(s) are also conducting materials.Type: ApplicationFiled: February 10, 2016Publication date: February 22, 2018Inventors: Ana Cecilia AFONSO ROQUE, Abid HUSSAIN, Jonas GRUBER, Ana Teresa SILVA SEMEANO
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Publication number: 20180051212Abstract: A material is proposed for making an electro-optical shutter device. The material includes a host nematic liquid crystal, at least one guest chiral dopant and one guest black dichroic dye. The birefringence (?n) of the host nematic liquid crystal is greater than 0.20. The concentration of the at least one chiral dopant is adjusted so that the material has a pitch in the range of 500 nm to 800 nm. The concentration of the guest black dichroic dye ranges from 2% to 4% by weight of the material. The dichroic ratio of the guest black dichroic dye is greater than or equal to 8.Type: ApplicationFiled: February 26, 2016Publication date: February 22, 2018Inventors: Jean-Louis De Bougrenet De La Tocnaye, Laurent Dupont, Kedar Sathaye, SumanKalyan Manna
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Publication number: 20180051213Abstract: Production of bitumen from bitumen froth can include separating the froth into a solvent diluted tailings and solvent diluted bitumen, and then the diluted tailings can be treated to recover solvent for reuse in the froth separation. The solvent recovery from tailings can employ a distributor for use in a tailings solvent recovery unit (TSRU). The distributor can include slot-shaped pressure let-down apertures and a closed curved end portion to introduce the tailings into a separation vessel. The distributor construction can have various advantages, such as facilitating manufacturing as well as effective mitigation of pre-flashing and solids segregation issues, for enhanced bitumen production and solvent recovery operations.Type: ApplicationFiled: June 29, 2017Publication date: February 22, 2018Inventors: Shawn Van Der Merwe, Mohammad Shariati, Ali Vakil, Benito Moyls, Bryan Demko
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Publication number: 20180051214Abstract: Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.Type: ApplicationFiled: August 21, 2017Publication date: February 22, 2018Applicant: The University of ToledoInventors: Yaser Shirazi, Sridhar Viamajala, Sasidhar Varanasi
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Publication number: 20180051215Abstract: A method of obtaining a liquefied hydrocarbon-rich fraction (product fraction) having a nitrogen content of ?1 mol %, wherein the hydrocarbon-rich fraction is liquefied and subcooled with a refrigeration circuit and then subjected to a rectificative removal of nitrogen is disclosed.Type: ApplicationFiled: March 1, 2016Publication date: February 22, 2018Inventors: Heinz Bauer, Michael Warter
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Publication number: 20180051216Abstract: This invention provides a process for removing mercury, from a mercury-containing hydrocarbon fluid. More specifically, the invention relates to a process for the removal of mercury from a mercury-containing hydrocarbon fluid feed comprising the steps of: (i) contacting the mercury-containing hydrocarbon fluid feed with a metal perhalide having the following formula: [M]+[X]? wherein: [M]+ represents one or more metal cations wherein the metal has an atomic number greater than 36; an atomic radius of at least 50 pm and a 1st ionization energy of less than 750 kJmol?1; [X]? represents one or more perhalide anions; and (ii) obtaining a hydrocarbon fluid product having a reduced mercury content compared to mercury-containing hydrocarbon fluid feed.Type: ApplicationFiled: March 2, 2016Publication date: February 22, 2018Applicant: Petroliam Nasional Berhad (Petronas)Inventors: Yong Cheun Kuah, John David Holbrey, Martin Philip Atkins
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Publication number: 20180051217Abstract: Treatment of hydrocarbon streams, and in one non-limiting embodiment refinery distillates, with reducing agents, such as borohydride and salts thereof, alone or together with at least one co-solvent results in reduction of the sulfur compounds such as disulfides, mercaptans, thiophenes, and thioethers that are present to give easily removed sulfides. In one non-limiting embodiment, the treatment converts the original sulfur compounds into hydrogen sulfide or low molecular weight mercaptans that can be extracted from the distillate with caustic solutions, hydrogen sulfide or mercaptan scavengers, solid absorbents such as clay or activated carbon or liquid absorbents such as amine-aldehyde condensates and/or aqueous aldehydes.Type: ApplicationFiled: October 31, 2017Publication date: February 22, 2018Applicant: Baker Hughes, a GE company, LLCInventors: Jerry J. Weers, Timothy J. O'Brien, Waynn C. Morgan
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Publication number: 20180051218Abstract: A process and catalyst is disclosed for converting heavy hydrocarbon feed into lighter hydrocarbon products using multifunctional catalysts. Multifunctional catalysts enable use of less expensive metal by substituting expensive metals for less expensive metals with no loss or superior performance in slurry hydrocracking. Less available and expensive ISM can be replaced effectively.Type: ApplicationFiled: October 27, 2017Publication date: February 22, 2018Inventors: Phuong T. M. Do, Alakananda Bhattacharyya, Beckay J. Mezza, Stephen C. Houdek
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Publication number: 20180051219Abstract: A process and catalyst is disclosed for converting heavy hydrocarbon feed into lighter hydrocarbon products using multifunctional catalysts. Multifunctional catalysts enable use of less expensive metal by substituting expensive metals for less expensive metals with no loss or superior performance in slurry hydrocracking. Less available and expensive ISM can be replaced effectively.Type: ApplicationFiled: October 27, 2017Publication date: February 22, 2018Inventors: Phuong T. M. Do, Alakananda Bhattacharyya, Beckay J. Mezza, Stephen C. Houdek
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Publication number: 20180051220Abstract: Disclosed herein are motor fuels providing enhanced properties for use with 2-stroke and 4-stroke engines. The fuels comprise isooctane, alkylate, mesitylene, isopentane and butane, and optionally a special lube oil premixed in solution.Type: ApplicationFiled: November 1, 2017Publication date: February 22, 2018Applicant: Swift Fuels, LLCInventors: Chris D'Acosta, Thomas Albuzat
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Publication number: 20180051221Abstract: Disclosed herein are fuel formulations comprising C4-C12 aliphatic hydrocarbons and cumidine. In embodiments, the formulations further include a limited amount of aromatic hydrocarbons. In other embodiments, the aliphatic hydrocarbons are alkylates, and in still other embodiment the alkylates are alkanes. These fuel formulations provide unique and advantageous physical properties suitable for piston engines.Type: ApplicationFiled: November 1, 2017Publication date: February 22, 2018Applicant: Swift Fuels, LLCInventors: Chris D'Acosta, Tomas Albuzat
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Publication number: 20180051222Abstract: Described are preferred compositions for a motor fuel. Such motor fuels may be particularly well suited for use in the motor of an aircraft. In particular, compositions of the present disclosure may comprise 50-75 wt % isooctane/alkylates, 20-40 wt % ETBE, 0-3 wt % isobutane, and 0-5 wt % aromatics. The present disclosure describes a full spectrum of unleaded fuels with various motor octane (MON) values.Type: ApplicationFiled: November 1, 2017Publication date: February 22, 2018Applicant: Swift Fuels LLCInventors: Chris D'Acosta, Thomas Albuzat
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Publication number: 20180051223Abstract: A lubricant made by a method of modifying fluid suspended metal sulfide particles that does not require use of hazardous additives. The base oil is derived from a proprietary ester lubricant. The formulation process includes a centrifugation step to remove non-colloidal metal sulfide particles. These non-colloidal particles may be collected and turned into colloidal particles for use in future batches of lubricant.Type: ApplicationFiled: August 18, 2017Publication date: February 22, 2018Applicant: Tap it All LubricantsInventors: Matthew Scott Pettersen, Eric M. Pettersen
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Publication number: 20180051224Abstract: The disclosed technology provides a lubricating composition comprising an oil of lubricating viscosity and 0.2 wt % to 10 wt % of a salt of a hydroxyl functional aromatic compound. The disclosed technology further relates to a method of lubricating a mechanical device with the lubricant composition.Type: ApplicationFiled: February 25, 2016Publication date: February 22, 2018Inventors: Kamalakumari KUNCHITHAPATHAM SALEM, David J. MORETON, Mohamed G. FAHMY, Gary M. WALKER, James P. ROSKI, Adam COX, W. Preston BARNES, Ewan E. DELBRIDGE, Jason E. MELVIN, Robert D. DURA
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Publication number: 20180051225Abstract: Flooding compounds for telecommunications cables. Such flooding compounds contain a polyolefin elastomer and a hydrocarbon oil. The polyolefin elastomer has a crystallinity ranging from 10 less than 50 weight percent and a dynamic viscosity of 50,000 centipoise or less at 177° C. The hydrocarbon oil has a kinematic viscosity of 200 centistokes or less at 40° C.Type: ApplicationFiled: March 14, 2016Publication date: February 22, 2018Inventors: Yichi ZHANG, Mohamed ESSEGHIR, Chester J. KMIEC, Yi JIN, Selim YALVAC
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Publication number: 20180051226Abstract: The present invention relates to the use of highly viscous (per)fluoropolyether polymers as damping fluids and to a method for counteract vibrations and/or shocks in a device using highly viscous (per)fluoropolyether polymers.Type: ApplicationFiled: March 22, 2016Publication date: February 22, 2018Inventors: Ugo DE PATTO, Sara ROVINETTI, Giovanni BOCCALETTI, Fabio RIGANTI
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Publication number: 20180051227Abstract: The disclosure relates to an improved grease composition for use in constant velocity joints, especially ball joints and/or tripod joints used in the drivelines of motor vehicles, with the grease composition comprising at least one base oil, at least one simple or complex soap thickener, at least one zinc sulphonate, at least one molybdenum dithiocarbamate in the solid state, and at least one molybdenum dithiophosphate.Type: ApplicationFiled: March 31, 2015Publication date: February 22, 2018Inventors: Jisheng E., Stefanie Rosenkranz, Jörg Berlingen, Frank Reher
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Publication number: 20180051228Abstract: The lubricating oil composition for four-stroke cycle engine of the present invention includes a base oil (A) and from 0.5 to 10% by mass of a polyolefin (B) having at least an isobutene-derived constituting unit and having a number average molecular weight of 500 to 10,000, with a sulfated ash content being from 0.3 to 1.2% by mass.Type: ApplicationFiled: March 31, 2016Publication date: February 22, 2018Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Hirotaka YAMASAKI
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Publication number: 20180051229Abstract: A system for modifying viscosity of a lubricant. The system including a viscosity modification device configured to change viscosity of the lubricant between a first viscosity and a second viscosity. The second viscosity is lower than the first viscosity.Type: ApplicationFiled: August 16, 2016Publication date: February 22, 2018Inventor: Michael BIMA
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Publication number: 20180051230Abstract: The invention provides methods for obtaining lipid compositions comprising phospholipids having a high docosahexaenoic acid (DHA) content, which compositions are preferably extracted from natural sources such as fish roe. The lipid compositions are excellent sources of highly bioavailable DHA and they can be used in oral delivery vehicles, dietary supplements, functional foods, and the like.Type: ApplicationFiled: March 21, 2016Publication date: February 22, 2018Applicant: Arctic Nutrition ASInventors: Per Christian SAEBO, Daniele MANCINELLI
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Publication number: 20180051231Abstract: A perfume composition comprising at least 2 perfume ingredients, having a known Sandman Classifier (SC) value of at least 1.35. Preferred perfume compositions exhibit SC values of 1.35 to about 150, more particularly 1.35 to about 75, and still more particularly 1.35 to about 3. The composition enhances the quality of sleep.Type: ApplicationFiled: March 16, 2016Publication date: February 22, 2018Applicant: GIVAUDAN SAInventors: Ioannis KONTARIS, Jeremy Nicholas NESS, Jennifer SUMMERFIELD, Chi ZHANG
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Publication number: 20180051232Abstract: A hand dishwashing cleaning composition including a surfactant system and an amine of Formula (I): R1-N—R2R3 ??(I) wherein R1 is a cyclic or acyclic polyhydroxyhydrocarbyl; R2 is hydrogen or methyl; and R3 is a C6 to C30 hydrocarbyl.Type: ApplicationFiled: August 16, 2017Publication date: February 22, 2018Inventors: Patrick Firmin August DELPLANCKE, Phillip Kyle VINSON, Randall Thomas REILMAN, Jeffrey John SCHEIBEL, Scott Leroy CRON, Ryan Michael WEST, Jamila TAJMAMET, Frank HULSKOTTER, Prakash J. MADHAV, David Thomas STANTON
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Publication number: 20180051233Abstract: A hand dishwashing cleaning composition including a surfactant system and an amine of Formula (I): R1—N—R2R3 ??(I) wherein: R1 is an acyclic or cyclic polyhydroxyhydrocarbyl; and R2 and R3 are independently selected from: i) hydrogen, wherein R2 and R3 are not both hydrogen; ii) substituted or unsubstituted C1 to C3 hydrocarbyl; and iii) acyclic or cyclic polyhydroxyhydrocarbyl as defined for R1.Type: ApplicationFiled: August 16, 2017Publication date: February 22, 2018Inventors: Patrick Firmin August DELPLANCKE, Phillip Kyle VINSON, Randall Thomas REILMAN, Jeffrey John SCHEIBEL, Scott Leroy CRON, Ryan Michael WEST, Jamila TAJMAMET, Frank HULSKOTTER, Prakash J. MADHAV, David Thomas STANTON
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Publication number: 20180051234Abstract: A hand dishwashing cleaning composition including a surfactant system and an amine of Formula (I): R1-N-(R2)(CH2CHOH(CH2O)nR3)??(I) wherein R1 and R2 are independently selected from hydrogen, cyclic or acyclic, linear or branched C1 to C10 alkyl, C1 to C10 hydroxyalkyl, polyhydroxyhydrocarbyl and polyalkoxy of formula (R4-O)xH with R4 being C1-C4 and x=1 to 15; n is 0 or 1, preferably 1; and R3 is a C6 to C30 hydrocarbyl.Type: ApplicationFiled: August 16, 2017Publication date: February 22, 2018Inventors: Patrick Firmin August DELPLANCKE, Phillip Kyle VINSON, Neil Thomas FAIRWEATHER, Scott Leroy CRON, Jamila TAJMAMET, Prakash J. MADHAV, David Thomas STANTON
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Publication number: 20180051235Abstract: The present invention relates to fabric cleaning and/or treatment compositions as well as methods of making and using same. Such fabric cleaning and/or treatment compositions contain species of glyceride copolymers that have the required viscosity and lubricity. Thus, such species of glyceride copolymers provide improved softening performance and formulability.Type: ApplicationFiled: August 18, 2016Publication date: February 22, 2018Inventors: Beth Ann SCHUBERT, Rajan Keshav PANANDIKER, Luke Andrew ZANNONI, Stephanie Ann URBIN, Mark Robert SIVIK
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Publication number: 20180051236Abstract: Linen treatment compositions and linen processes are disclosed which help to prevent iron deposition from wash water, and/or redeposition after iron containing stain (such as blood) removal by alkaline detergents. The linen treatment composition is a combination of a hydroxycarboxylic acid and an acid source, which may be organic or inorganic. The invention provides for effective iron control in a phosphorus-free formula that is also free of toxic or hazardous chemicals and includes sustainable, environmentally friendly ingredients, while still providing effective iron control.Type: ApplicationFiled: September 1, 2017Publication date: February 22, 2018Inventors: SUKHWAN SOONTRAVANICH, STEPHAN HUBIG, ALTONY J. MIRALLES
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Publication number: 20180051237Abstract: To provide a composition for removing photoresist residue and/or polymer residue formed in a process for producing a semiconductor circuit element, and a removal method employing same. A composition for removing photoresist residue and/or polymer residue, the composition containing saccharin and water, and the pH being no greater than 9.7.Type: ApplicationFiled: October 30, 2015Publication date: February 22, 2018Applicant: Kanto Kagaku Kabushiki KaishaInventor: Yasuyuki Seino
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Publication number: 20180051238Abstract: The present invention belongs to the area of detergents and refers to a dispersion comprising encapsulated fragrances and the method as well as the use of the said dispersion in a process to adhere said encapsulated fragrances onto particles, powder or granules of detergent compositions.Type: ApplicationFiled: February 11, 2016Publication date: February 22, 2018Inventors: Sven SIEGEL, Jörg DRÖGE, Jörn WIEDEMANN, Benjamin ROST
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Publication number: 20180051239Abstract: A method is provided for treating distiller's grains with solubles (DGS) to produce one or more byproducts. The method includes separating the DGS into a low protein mixture and a high protein mixture. The method includes generating, from the low protein mixture, a biogas by an anaerobic digestion process. The method includes generating, from the high protein mixture, at least one of a vegetable oil from a vegetable oil separation process, a high protein animal feed from a separation process and a microalgae biomass material from a microalgae production process.Type: ApplicationFiled: August 11, 2017Publication date: February 22, 2018Inventor: Guo Yu
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Publication number: 20180051240Abstract: A frequency conversion ultrasonic wine aging device for bottled wine comprises a base (1), and an opening portion formed by extending upwards along a peripheral edge of the base (2); a container is arranged in the opening portion and used for containing a sound conducting medium solution; when the frequency conversion ultrasonic wine aging device is used, a wine bottle (3) is placed in the container and immersed in the sound conducting medium solution; an ultrasonic transducer (21) and a control circuit board (23) are mounted in the base (2); the control circuit board (23) is provided thereon with an ultrasonic generating unit and an ultrasonic frequency modulation unit; the ultrasonic generating unit is used for converting a commercial power into an ultrasonic frequency alternating current signal; the ultrasonic frequency modulation unit serves to modulate the frequency of the ultrasonic frequency alternating current signal so that the frequency of the ultrasonic frequency alternating current signal varied cType: ApplicationFiled: August 19, 2016Publication date: February 22, 2018Inventor: Wing Keung AU
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Publication number: 20180051241Abstract: A cultivation bottle for mycelium of Inonotus obliquus is provided. The cultivation bottle includes a bottle having a hollow shape and configuring to contain a matrix which includes an agar plate, sawdust distributed uniformly in the agar plate, and Inonotus obliquus strain seeded in the agar plate; and a bottle cap configured to cover the opening of the bottle. The bottle cap includes an annular cap defining a space, a press cap disposed in the space and having a bottom part and a press part; and at least one elastic member disposed under the press part within the space, so that the press part and the bottom part enclose the space for containing culture liquid.Type: ApplicationFiled: January 9, 2017Publication date: February 22, 2018Inventor: Po-Lun Wang
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Publication number: 20180051242Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.Type: ApplicationFiled: August 30, 2017Publication date: February 22, 2018Inventors: David Alan Kenney, Gregory Roger Martin, Allison Jean Tanner, Joseph Christopher Wall
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Publication number: 20180051243Abstract: A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the syringe is capable of translational movement relative to the transfer carousel; a drive motor connected to the syringe that is capable of controlling the position of the plunger; and a peripheral module comprising at least one vessel that is capable of containing a fluid, wherein the vessel has an opening that can be mated with the syringe to allow fluid transfer between the vessel and the syringe. Methods for transferring a fluid are also disclosed.Type: ApplicationFiled: March 11, 2016Publication date: February 22, 2018Applicant: The Trustees of the University of PennsylvaniaInventors: Michael HOGAN, Orkan M. TELHAN, Karen HOGAN
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Publication number: 20180051244Abstract: System and method for controlling the temperature of a specimen by dry thermal equilibration using glass beads are provided. The method includes the use of a bed of glass beads that can be maintained at a relatively constant temperature in the range from about ?80° C. to about +100° C. The system includes a container including the bed of glass beads and a temperature control mechanism capable of maintaining the temperature of the glass beads at a desired set temperature.Type: ApplicationFiled: August 17, 2016Publication date: February 22, 2018Inventor: Daniel Perlman
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Publication number: 20180051245Abstract: A system for digesting biodigestible feed that preferably includes the steps of comminuting the feed, introducing feed, an oxygen-containing gas, an accelerant, and bacteria into a digestion zone, the bacteria being suitable for digesting the feed under aerobic, anaerobic, and anoxic conditions. The contents of the digestion zone can be changed from aerobic operation to either anoxic or anaerobic operation, or vice versa, without changing the bacteria in the digestion zone.Type: ApplicationFiled: October 27, 2017Publication date: February 22, 2018Inventors: William Nicholas Hiatt, Mohammed Memon, Jacob J.L. Dickinson, James DeWitt Stein, Gary Ailes
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Publication number: 20180051246Abstract: Compositions including metal nano- and/or micro-particles in solution with photosynthetic bioproduct producing microorganisms. These light harvesting complexes increase growth rates and photosynthetic efficiency of the constituent microorganisms, reducing the light required for a specific production level, or increases production for a specific light level.Type: ApplicationFiled: August 16, 2017Publication date: February 22, 2018Inventors: Viji Sitther, Kadir Aslan
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Publication number: 20180051247Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: ApplicationFiled: December 16, 2015Publication date: February 22, 2018Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikoleavich Goral, David Henry, Martial Hervy, Corinne walerack, Yue Zhou
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Publication number: 20180051248Abstract: Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (DA) neurons using a mono-SMAD inhibition or inhibition of SMAD signaling with only one SMAD inhibitor. In some embodiments, mono-SMAD inhibition utilizes a single inhibitor of bone morphogenic protein (BMP) for differentiating pluripotent cells into midbrain DA neurons.Type: ApplicationFiled: August 16, 2017Publication date: February 22, 2018Applicant: Cellular Dynamics International, Inc.Inventors: Christopher W. McMAHON, Lauren E. LITTLE, Wen Bo WANG, Nathaniel A. Elliott
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Publication number: 20180051249Abstract: Provided herein according to some embodiments is a method for producing an induced neural stem cell (iNSC), which method may include one or more of the steps of: providing a somatic cell; introducing into (e.g., by transfecting or transducing) said somatic cell with a nucleic acid encoding Sox2, whereby said cell expresses Sox2; and then transdifferentiating said somatic cell (e.g., by growing the cell in a neural progenitor medium), to thereby make said induced neural stem cell. In some embodiments, the transdifferentiating is carried out for a time of from 1 to 10 days, from 1 to 5 days, from 1 to 3 days, or from 12 to 24 or 48 hours.Type: ApplicationFiled: March 3, 2016Publication date: February 22, 2018Inventors: Shawn D. HINGTGEN, Raluca DUMITRU, Julio RODRIGUEZ BAGO
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Publication number: 20180051250Abstract: Culture media, which contain chelated iron, promote cell proliferation of neural stem cells and/or neural progenitor cells while maintaining undifferentiated state and multipotency.Type: ApplicationFiled: September 28, 2017Publication date: February 22, 2018Applicant: AJINOMOTO CO., INC.Inventors: Takuya MATSUMOTO, Sho SENDA, Tsuyoshi KOBAYASHI, Akihiro ARAKAWA
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Publication number: 20180051251Abstract: Cultured sebaceous gland cells capable of accumulating lipid droplets therein are provided. A method for producing mature human sebaceous gland cells, comprising culturing immature human sebaceous gland cells under hypoxic conditions.Type: ApplicationFiled: February 8, 2016Publication date: February 22, 2018Applicant: KAO CORPORATIONInventors: Takayoshi INOUE, Akira HACHIYA
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Publication number: 20180051252Abstract: The present disclosure relates to luterial, which is a mitochondrial-like unidentified nano-sized particle derived from a body fluid, and to a method for isolating the same.Type: ApplicationFiled: June 26, 2017Publication date: February 22, 2018Inventors: Won Cheol Choi, Young Ah Kwon, Suk Hoon Choi, Chang Hoon Choi
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Publication number: 20180051253Abstract: Methods of preventing and reversing stem cell aging including the step of activating the mitochondrial unfolded protein response in a stem cell are described. Further described are methods of promoting stem cell maintenance and methods of preventing and/or reversing tissue degeneration or injury including the step of activating the mitochondrial unfolded protein response.Type: ApplicationFiled: March 18, 2016Publication date: February 22, 2018Applicant: The Regents of the University of CaliforniaInventor: Danica CHEN
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Publication number: 20180051254Abstract: The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti CD4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts and uses. The invention further relates to the modification of antibodies reactive to the CD4 human leukocyte antigen to provide anti-CD4 antibodies that have a reduced number of potential T-cell epitopes but retain the ability to bind to CD4, such as to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains.Type: ApplicationFiled: October 18, 2017Publication date: February 22, 2018Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Stephan FRICKE, Frank EMMRICH, Nadja HILGER
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Publication number: 20180051255Abstract: A cell culture system including a silk fibroid scaffold, culture media, and pancreatic cells. The pancreatic cells grown in the tissue culture system have physiological and morphological features like those of in vivo pancreatic cells. The cell culture system can be used to produce a pancreatic tissue-specific extracellular matrix capable of inducing differentiation of pancreatic cell precursors into pancreatic cells.Type: ApplicationFiled: March 24, 2016Publication date: February 22, 2018Inventors: Anson Joo L. ONG, Jose OBERHOLZER, Xiao-Dong CHEN
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Publication number: 20180051256Abstract: This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3? inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF.Type: ApplicationFiled: March 2, 2016Publication date: February 22, 2018Applicant: KYOTO UNIVERSITYInventors: Shimpei GOTOH, Yuki YAMAMOTO, Satoshi KONISHI, Michiaki MISHlMA
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Publication number: 20180051257Abstract: A method for generating alveolar type II (AT II) cells or lung epithelial cells is disclosed. The method comprises a two-step differentiation protocol to generate alveolar type II (AT II) cells from one or more embryonic stem cells (mESC). The two-step differential protocol is performed by first step of, inducing the embryonic stem cells (mESC) by a definitive endoderm (DE) inducer to produce mESC-DE cells at a first period of time. The second step includes, inducing the mESC-DE cells by one or more growth promoting factors at a second period of time to generate AT (II) cells. The method for generating AT (II) cells from the embryonic stem cells (mESC) ensures abundant production of AT (II) cells for the treatment of pulmonary diseases. Moreover, the main function of AT (II) cells is the production of surfactants, which could be used for the treatment of lungs related diseases.Type: ApplicationFiled: July 18, 2017Publication date: February 22, 2018Inventors: Sirous Sadeghian Chaleshtori, Mohammad Reza Mokhber Dezfouli, Hossein Baharvand, Yaser Tahamtani
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Publication number: 20180051258Abstract: The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.Type: ApplicationFiled: October 2, 2017Publication date: February 22, 2018Inventors: Chengkang ZHANG, Joseph R. BLASIC, JR., R. Daniel SLONE
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Publication number: 20180051259Abstract: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.Type: ApplicationFiled: November 8, 2016Publication date: February 22, 2018Inventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
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Publication number: 20180051260Abstract: Provided is a method for producing a stem cell clone, which comprises the steps of: (i) introducing into stem cells an exogenous gene associated with induction of differentiation into somatic cells; (ii) inducing differentiation of the stem cells, introduced with an exogenous gene, into the somatic cells; (iii) dedifferentiating the differentiation-induced somatic cells; and (iv) isolating stem cells having the exogenous gene incorporated into a chromosome thereof from a colony of the stem cells formed in step (iii).Type: ApplicationFiled: April 14, 2016Publication date: February 22, 2018Inventors: Koji Eto, Hiroshi Endo, Tomohiro Shigemori