Patents Issued in March 22, 2018
  • COMPOUNDS WITH ANTI-TUMORAL ACTIVITY
    Publication number: 20180079747
    Abstract: The present invention relates to compounds of general formula (I). wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description.
    Type: Application
    Filed: February 5, 2016
    Publication date: March 22, 2018
    Inventors: Alain Moussy, Abdellah Benjahad, Didier Pez, Franck Sandrinelli, Jason Martin, Willy Picoul, Emmanuel Chevenier
  • PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
    Publication number: 20180079748
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
    Type: Application
    Filed: March 7, 2016
    Publication date: March 22, 2018
    Applicant: Syngenta Participations AG
    Inventors: Pierre Joseph Marcel JUNG, Andrew EDMUNDS, Michel MUEHLEBACH, Roger Graham HALL, Jerome Yves CASSAYRE
  • PROCESS OF SYNTHESIZING SUBSTITUTED PYRIDINE AND PYRIMIDINE COMPOUND
    Publication number: 20180079749
    Abstract: Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method for preparing a compound of formula III via a compound of formula II?, wherein the definition of each of groups is as described as the description. Compound with other methods, the method in the present invention has features of high yield and a result product being easier to separate.
    Type: Application
    Filed: March 24, 2016
    Publication date: March 22, 2018
    Inventors: Jingkang SHEN, Tao MENG, Ting YU, Lanping MA, Xin WANG, Lin CHEN
  • NOVEL COMPOSITIONS, USES AND METHODS FOR MAKING THEM
    Publication number: 20180079750
    Abstract: Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: July 27, 2017
    Publication date: March 22, 2018
    Inventor: MUSTAPHA HADDACH
  • PROCESS FOR PRODUCING PURINONE DERIVATIVE
    Publication number: 20180079751
    Abstract: According to the present invention, differently from well-known production methods, with the use of a different starting material, Ullmann condensation which may decrease the yield with an increase of a production scale can be avoided and thus 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one can be provided safely and stably with high reaction yield.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 22, 2018
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Ryo SUZUKI, Atsushi HIRAMATSU, Motoaki TATEYAMA, Hideyuki SASAHARA
  • BTK INHIBITORS
    Publication number: 20180079752
    Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
    Type: Application
    Filed: May 31, 2016
    Publication date: March 22, 2018
    Applicants: MERCK SHARP & DOHME CORP., MERCK SHARP & DOHME B.V.
    Inventors: ADRIANUS PETRUS ANTONIUS DE MAN, RONALD KIM, JIAN LIU, JOSEPH A. KOZLOWSKI, SOBHANA BABU BOGA, THIERRY FISCHMANN, DEODIAL Guy GUIADEEN, ILSE HENDRICA MARIA POLS-DE ROOIJ, SHILAN LIU, HAO WU
  • INHIBITORS OF CELLULAR METABOLIC PROCESSES
    Publication number: 20180079753
    Abstract: The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA): wherein RA, RB, RC, RD, and RE are defined herein.
    Type: Application
    Filed: August 30, 2017
    Publication date: March 22, 2018
    Inventors: Zenon D. Konteatis, Zhihua Sui, Jeremy M. Travins, Zhixiong Ye
  • TEMOZOLOMIDE COMPOUNDS, POLYMERS PREPARED THEREFROM, AND METHOD OF TREATING A DISEASE
    Publication number: 20180079754
    Abstract: A temozolomide compound according to formula (I) is described, wherein R1, L1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.
    Type: Application
    Filed: September 20, 2017
    Publication date: March 22, 2018
    Inventors: Todd Emrick, Matthew Skinner, Sarah M. Ward, Banishree Saha
  • PROCESS FOR THE SYNTHESIS OF E1 ACTIVATING ENZYME INHIBITORS
    Publication number: 20180079755
    Abstract: The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((4S, 2S, 4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 22, 2018
    Inventors: Ian Armitage, Eric L. Elliott, Marianne Langston, Steven P. Langston, Quentin J. McCubbin, Hiro Mizutani, Matthew Stirling, Lei Zhu
  • HETEROCYCLIC COMPOUND
    Publication number: 20180079756
    Abstract: The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
    Type: Application
    Filed: March 29, 2016
    Publication date: March 22, 2018
    Inventors: Shuhei IKEDA, Tatsuki KOIKE, Jumpei AIDA, Makoto FUSHIMI, Tomokazu KUSUMOTO, Hideyuki SUGIYAMA, Masako MIYAZAKI, Hidekazu TOKUHARA, Yasushi HATTORI, Makoto KAMATA
  • BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY
    Publication number: 20180079757
    Abstract: The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.
    Type: Application
    Filed: September 18, 2017
    Publication date: March 22, 2018
    Inventors: Yuk-Ching TSE-DINH, Dianqing SUN
  • SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS
    Publication number: 20180079758
    Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 22, 2018
    Inventors: Douglas G. Batt, Myra Beaudoin Bertrand, George V. Delucca, Michael A. Galella, Soo Sung Ko, Charles M. Langevine, Qingjie Liu, Qing Shi, Anurag S. Srivastava, Joseph A. Tino, Scott Hunter Watterson
  • Boron-Containing Diacylhydrazines
    Publication number: 20180079759
    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 22, 2018
    Applicant: Intrexon Corporation
    Inventors: Sheela K. CHELLAPPAN, Robert E. Hormann, Inna Shulman
  • BETA-LACTAMASE INHIBITORS
    Publication number: 20180079760
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 22, 2018
    Inventors: Christopher J. BURNS, Denis DAIGLE, Bin LIU, Daniel McGARRY, Daniel C. PEVEAR, Robert E. Lee TROUT
  • High-RI siloxane monomers, their polymerization and use
    Publication number: 20180079761
    Abstract: Phenoxyphenylsilane monomers were synthesized and polymerized. The polymers have high refractive indices and excellent UV and thermal stability. Their water and oxygen permeability is lower than commercial phenyl silicone elastomers. They show good compatibility with metal oxide nanoparticles. The polymers of the invention are suitable as LED encapsulant, as light guide material in CMOS image sensors, in OLED devices, lasers and in other optical applications.
    Type: Application
    Filed: March 21, 2016
    Publication date: March 22, 2018
    Inventors: Jyri Paulasaari, Juha Rantala
  • Carbidopa and L-Dopa Prodrugs and Methods of use
    Publication number: 20180079762
    Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
    Type: Application
    Filed: September 26, 2017
    Publication date: March 22, 2018
    Applicant: AbbVie Inc.
    Inventors: Benoit Cardinal-David, Vincent S. Chan, Kassibla Dempah, Brian P. Enright, Rodger F. Henry, Raimundo Ho, Ye Huang, Alexander D. Huters, Russell C. Klix, Scott W. Krabbe, Philip R. Kym, Yanbin Lao, Xiaochun Lou, Sean E. Mackey, Mark A. Matulenko, Peter T. Mayer, Christopher P. Miller, James Stambuli, Eric A. Voight, Zhi Wang, Geoff G. Zhang, Valentino J. Stella
  • TRIPHENYLPHOSPHINE OXIDE DERIVATIVE AND ELECTROPHOSPHORESCENT LUMINESCENT DEVICE
    Publication number: 20180079763
    Abstract: A triphenylphosphine oxide derivative is described, which is applied to a phosphorescence host and an electron transport material. R in a structural formula of the triphenylphosphine oxide derivative is H or a substituent group with an electron transporting property. An electrophosphorescent luminescent device is further described. An electron mobility and a luminous efficiency of a light emitting device are improved and a roll-off efficiency of the light emitting device is reduced by all using H or substituent groups with electron transporting properties as R groups of the triphenylphosphine oxide derivative.
    Type: Application
    Filed: December 1, 2016
    Publication date: March 22, 2018
    Inventor: Biao PAN
  • CHEMICAL DEPOSITION RAW MATERIAL INCLUDING HETEROGENEOUS POLYNUCLEAR COMPLEX AND CHEMICAL DEPOSITION METHOD USING THE CHEMICAL DEPOSITION RAW MATERIAL
    Publication number: 20180079764
    Abstract: The present invention relates to a chemical deposition raw material including a heterogeneous polynuclear complex in which as ligands, at least a diimine and a carbonyl are coordinated to a first transition metal and a second transition metal as central metals, and the chemical deposition raw material is represented by the following formula. In the formula, the first transition metal (M1) and the second transition metal (M2) are mutually different. The number of diimines (L) is 1 or more and 2 or less, and to the diimine is coordinated one of a hydrogen atom and an alkyl group with a carbon number of 1 or more and 5 or less as each of substituents R1 to R4. With the present chemical deposition raw material, a composite metal thin film or a composite metal compound thin film containing a plurality of metals can be formed from a single raw material.
    Type: Application
    Filed: May 9, 2016
    Publication date: March 22, 2018
    Inventors: Ryosuke HARADA, Toshiyuki SHIGETOMI, Shunichi NABEYA, Kazuharu SUZUKI, Akiko KUMAKURA, Tatsutaka AOYAMA, Takayuki SONE
  • Double Metal Cyanide Catalyst and Epoxide/Carbon Dioxide Copolymer Prepared Using the Same
    Publication number: 20180079765
    Abstract: Provided are a double metal cyanide (DMC) catalyst used in copolymerization of an epoxide/carbon dioxide useful for preparing polyurethane, a foaming agent, an elastomer, sealant, a coating material, and the like, and an epoxide/carbon dioxide copolymer prepared using the same. In addition, the present invention provides a double metal cyanide (DMC) catalyst prepared using an ion-exchange resin without washing alcohol, and an epoxide/carbon dioxide copolymer having a high purity, a high selectivity, and a high carbonate content prepared using the same.
    Type: Application
    Filed: October 17, 2017
    Publication date: March 22, 2018
    Inventors: Il Gu Jung, Ji Su Jeong, Kodiyan Varghese Jobi, Jong Chan Kim, Bun Yeoul Lee, Han Sol Lee, Je Ho Lee, Jeon Koo Lee
  • METHODS FOR PREPARING THERMALLY STABLE LIGNIN FRACTIONS
    Publication number: 20180079766
    Abstract: The present invention relates to fractions of high purity lignin which are thermally stable, and to methods of producing said fractions from lignocellulosic material.
    Type: Application
    Filed: May 12, 2017
    Publication date: March 22, 2018
    Inventors: Robert Jansen, James Alan Lawson, Noa Lapidot, Bassem Hallac, Perry Rotem
  • METHODS OF PREPARING STEVIOL GLYCOSIDES AND USES OF THE SAME
    Publication number: 20180079767
    Abstract: Methods of preparing steviol glycosides, including Rebaudioside D, Rebaudioside E, Rebaudioside M, Rebaudioside N and Rebaudioside O are provided herein. Sweetener and sweetened consumables containing Rebaudioside D, Rebaudioside E, Rebaudioside M, Rebaudioside N and Rebaudioside O are also provided herein.
    Type: Application
    Filed: September 28, 2017
    Publication date: March 22, 2018
    Inventors: Avetik Markosyan, Siew Yin Chow, Khairul Nizam Bin Nawi
  • METHOD FOR PRODUCING GLYCOSIDE COMPOUNDS
    Publication number: 20180079768
    Abstract: The invention provides a production method of a glycoside compound or a salt thereof, which includes subjecting a thioether compound and an alcohol compound to a coupling reaction in the presence of a halogenating agent, a desiccant and a Lewis acid, and then distillation in the presence of at least one kind of additive selected from a sulfur-containing antioxidant and a maleimide group-containing compound to give a thioether compound and a step of subjecting a glycoside compound and a thioether compound to a coupling reaction in the presence of a halogenating agent, a desiccant and a Lewis acid to give a glycoside compound. By this method, a phosphoramidite preferable for the production (synthesis) of a nucleic acid can be produced more efficiently at a high purity.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 22, 2018
    Applicant: BONAC CORPORATION
    Inventors: Eriko AOKI, Takashi KINOSHITA, Akihiro ITOH, Tadaaki OHGI
  • NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20180079769
    Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
    Type: Application
    Filed: November 8, 2017
    Publication date: March 22, 2018
    Inventors: David TELLERS, Steven L. COLLETTI, Vadim DUDKIN, Jeffrey AARONSON, Aaron MOMOSE, Thomas Joseph TUCKER, Yu YUAN, Kathleen B. CALATI, Lu TIAN, Rubina G. PARMAR, Anthony W. SHAW, Weimin WANG, Rachel Anne STORR, Marina BUSUEK, Robert A. KOWTONIUK
  • NOVEL COMPOUND OF 4'-THIONUCLEOSIDE, AS WELL AS PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
    Publication number: 20180079770
    Abstract: The present invention relates to a novel compound of 4?-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4?-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.
    Type: Application
    Filed: March 28, 2016
    Publication date: March 22, 2018
    Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
    Inventors: Hong YE, Gang LIU, Nan YU, Hong ZENG, Mingliang ZHAO, Yan QING, Hua DENG, Wenjia LI, Donghong LI, Donghai SU, Wei ZHONG, Shaohua LI, Xunwei WU, Lichun WANG, Jingyi WANG
  • SOFOSBUVIR IN CRYSTALLINE FORM AND PROCESS FOR ITS PREPARATION
    Publication number: 20180079771
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Application
    Filed: November 28, 2017
    Publication date: March 22, 2018
    Inventors: Mauro GABOARDI, Marta CASTALDI, Graziano CASTALDI, Sara HELMY
  • SALTS OF HIV INHIBITOR COMPOUNDS
    Publication number: 20180079772
    Abstract: The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to process and intermediates useful for preparing such salts.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 22, 2018
    Inventors: Benjamin R. Graetz, Richard P. Polniaszek
  • PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS
    Publication number: 20180079773
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 22, 2018
    Inventors: Richard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
  • SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
    Publication number: 20180079774
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a norovirus, with a nucleoside, a nucleotide and an analog thereof.
    Type: Application
    Filed: October 27, 2017
    Publication date: March 22, 2018
    Inventors: Leonid Beigelman, Jerome Deval, Zhinan Jin
  • METHOD FOR PREPARING SUBSTITUTED 3,7-DIHYDROXY STEROIDS
    Publication number: 20180079775
    Abstract: The invention relates to processes for preparing 17-alkynyl-7-hydroxy-steroids, such as 17-Ethynyl-10R,13S-dimethyl 2,3,4,7,8R,9S, 10,11,12,13,14S,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthrene-3R,7R,17S-triol (also referred to as 17?-ethynyl-androst-5-ene-3?, 7?, 17?-triol), that are essentially free of process impurities having binding activity at nuclear estrogen receptors.
    Type: Application
    Filed: October 19, 2015
    Publication date: March 22, 2018
    Inventors: Steven K. White, Yu Ge, Yujin Huang
  • PROCESS FOR PREPARING BILE ACID DERIVATIVES
    Publication number: 20180079776
    Abstract: The present invention relates to processes for preparing compounds of formula I: or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: August 21, 2017
    Publication date: March 22, 2018
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • SOLUTION PHASE METHOD FOR PREPARING ETELCALCETIDE
    Publication number: 20180079777
    Abstract: The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
    Type: Application
    Filed: March 25, 2016
    Publication date: March 22, 2018
    Inventors: Sheng Cui, Krishnakumar Ranganathan, Richard Crockett, Ying Chen, Aleksander Swietlow, Kevin Crossley, Yun Shi, Karel Decroos, Etienne Moniotte
  • METHOD OF REMOVING PROTEIN AGGREGATE
    Publication number: 20180079778
    Abstract: Provided is a method of removing a protein aggregate which can obtain a useful protein monomer in a high yield and a high purity as a raw material of a pharmaceutical product or the like. The method of removing a protein aggregate includes: a step of making the monomer of a protein and the aggregate of proteins adsorb to the column by making a solution containing a monomer of a protein and an aggregate of proteins pass through a column containing a hard porous polymer self-supporting structure to which a strong cation exchange group is fixed; and a step of making a mobile phase consisting of a mixed solution of a buffer solution and an ionic buffer solution pass through the column to which the monomer of a protein and the aggregate of proteins are adsorbed, to selectively elute the monomer of a protein.
    Type: Application
    Filed: April 28, 2016
    Publication date: March 22, 2018
    Applicant: SHOWA DENKO K.K.
    Inventors: Yuzuru KOKIDO, Natsuno MATSUI, Hirobumi AOKI, Tadashi YONEDA
  • METHOD FOR THE PURIFICATION OF A THERAPEUTIC RECOMBINANT PROTEIN FROM TRANSGENIC MILK
    Publication number: 20180079779
    Abstract: The invention relates to a method for the purification of a therapeutic protein from transgenic milk, comprising a clarification step using a salt of poly(diallyldimethylammonium).
    Type: Application
    Filed: April 1, 2016
    Publication date: March 22, 2018
    Applicant: Laboratoire Francais du Fractionnement et des Biotechnologies
    Inventor: Sandrine DE MARCO
  • NOVEL PEPTIDE COMPOUND, PRODUCTION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20180079780
    Abstract: Provided are a novel peptide compound, a method of producing the same, and use of the peptide compound. Since the peptide compound has anticancer activity, the peptide compound may be used for the prevention or treatment of cancer.
    Type: Application
    Filed: October 23, 2015
    Publication date: March 22, 2018
    Inventors: Jong Heon Shin, Ki Bong Oh, Dong Chan Oh, Sang Kook Lee, Lijuan Liao, Min Jung You
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20180079781
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: October 17, 2017
    Publication date: March 22, 2018
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR
  • ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
    Publication number: 20180079782
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 22, 2018
    Inventors: Ashok Bhandari, Gregory Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • ORAL PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY BOWEL DISEASES
    Publication number: 20180079783
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 22, 2018
    Inventors: Ashok Bhandari, Gregory Bourne, Xiaoli Cheng, Brian Troy Frederick, Jie Zhang, Dinesh V. Patel, David Liu
  • Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase
    Publication number: 20180079784
    Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of search in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 4, 2016
    Publication date: March 22, 2018
    Inventors: Richard E. Lee, Ying Zhao, Liu Jiuyu
  • AZA-AMINO ACID COLLAGEN COMPOUNDS
    Publication number: 20180079785
    Abstract: The invention relates to aza-amino acid backbone-modified biomimetic collagens and general methods for designing and making biomimetic materials and molecular mimics.
    Type: Application
    Filed: April 28, 2017
    Publication date: March 22, 2018
    Inventors: David M. CHENOWETH, Yitao ZHANG
  • CONSTRUCTS FOR CONTINUOUS MONITORING OF LIVE CELLS
    Publication number: 20180079786
    Abstract: Embodiments disclosed herein provide nucleic acid constructs and methods of use thereof that induce a live cell to give off sub-samples of the cell's cytosolic content. The term “cell” as used herein may be any cell type. In certain example embodiments, the cells are mammalian cells. The sampling can be general or can be targeted to a particular class of molecules or to specific types of molecules. The constructs facilitate generation of a read-out for high-throughput screens by combining engineered export with simple bulk sample and sample processing. Live cell sampling enables time course measurements and expands, for example, the applicability of transcriptional profiles obtained by single cell gene expression analysis.
    Type: Application
    Filed: March 16, 2016
    Publication date: March 22, 2018
    Inventors: Paul Blainey, Jacob Borrajo
  • METHOD FOR INCREASING ETEC CS6 ANTIGEN PRESENTATION ON CELL SURFACE AND PRODUCTS OBTAINABLE THEREOF
    Publication number: 20180079787
    Abstract: A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETC. Cells and vaccines obtainable by the above methods.
    Type: Application
    Filed: October 6, 2017
    Publication date: March 22, 2018
    Inventors: Nils Carlin, Ann-Mari Svennerholm, Joshua Tobias
  • Constitutive Yeast LLP Promotor-Based Expression Systems
    Publication number: 20180079788
    Abstract: The present invention belongs to the field of biotechnology, recombinant protein production, molecular biology, microbiology and microbial genetics. It provides a modified eukaryotic cell that is modified to the effect that the modified eukaryotic cell is not able to provide an SSN6-like related protein or an SSN6-like protein that exerts its wildtype function and/or wildtype activity, the amount of SSN6-like related protein or of SSN6-like protein being present in the modified eukaryotic cell differs from the amount of SSN6-like related protein or of SSN6-like protein being present in its wildtype form, and/or essentially no SSN6-like related protein or SSN6-like protein is present in the modified cell. Additionally, the present invention provides a polynucleotide sequence comprising a modified ssn6-like related gene or modified ssn6-like gene, and a vector comprising said polynucleoptide.
    Type: Application
    Filed: March 2, 2016
    Publication date: March 22, 2018
    Applicant: Sandoz AG
    Inventors: Clemens Achmüller, Ferdinand Zepeck, Franz Hartner, Thomas Specht
  • TRANSGENIC PLANTS HAVING INCREASED BIOMASS
    Publication number: 20180079789
    Abstract: Methods and materials for modulating biomass levels in plants are disclosed. For example, nucleic acids encoding biomass-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased biomass levels and plant products produced from plants having increased biomass levels.
    Type: Application
    Filed: August 14, 2017
    Publication date: March 22, 2018
    Inventors: Chuan-Yin Wu, Han-Suk Kim, Gerard Magpantay, Fasong Zhou, Julissa Sosa, Greg Nadzan, Roger I. Pennell, Mircea Achiriloaie, Wuyi Wang
  • GROWTH DIFFERENTIATION FACTOR 15 (GDF-15) CONSTRUCTS
    Publication number: 20180079790
    Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
    Type: Application
    Filed: November 29, 2017
    Publication date: March 22, 2018
    Applicant: Amgen Inc.
    Inventors: Yumei XIONG, Yi ZHANG, Jackie Z. SHENG, Agnes Eva HAMBURGER, Murielle M. VENIANT-ELLISON, Grant SHIMAMOTO, Xiaoshan MIN, Zhulun WANG, Jie TANG, Gunasekaran KANNAN, Marissa MOCK, Kenneth William WALKER
  • CDCA1-DERIVED PEPTIDE AND VACCINE CONTAINING SAME
    Publication number: 20180079791
    Abstract: The present invention provides CDCA1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.
    Type: Application
    Filed: July 31, 2015
    Publication date: March 22, 2018
    Applicant: ONCOTHERAPY SCIENCE, INC.
    Inventors: TAKUYA TSUNODA, RYUJI OSAWA, SACHIKO YAMASHITA, TOMOHISA WATANABE
  • PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO PROMOTE ANTICANCER DRUG SENSITIVITY OF ANTICANCER DRUG-RESISTANT CANCER CELLS
    Publication number: 20180079792
    Abstract: The present invention relates to a peptide having eight amino acid sequences derived from CAGE and retaining anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells and, specifically, to a peptide, which has an amino acid sequence of SEQ ID NO: 1 (AQTGTGKT) and thus binds to the CAGE protein, thereby inhibiting an inter-linkage between CAGE and GSK3?, thus exhibiting anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells, and to a pharmaceutical composition, containing the peptide, for anticancer use or anticancer drug aiding.
    Type: Application
    Filed: November 17, 2017
    Publication date: March 22, 2018
    Inventors: Doo II Jeoung, Young Mi Kim, Hyun A Kim
  • IL2 and TNF Immunoconjugates
    Publication number: 20180079793
    Abstract: The present application relates to conjugates comprising interleukin 2 (IL2), and a tumour necrosis factor, such as tumour necrosis factor alpha (TNF?), and an antibody molecule. The antibody molecule preferably binds to an antigen associated with neoplastic growth and/or angiogenesis, such as the Extra-Domain A (EDA) of fibronectin. The conjugate may be used in the treatment of cancer.
    Type: Application
    Filed: May 5, 2016
    Publication date: March 22, 2018
    Inventors: Roberto DE LUCA, Francesca PRETTO, Sarah WULHFARD
  • PHARMACEUTICAL PREPARATION
    Publication number: 20180079794
    Abstract: Preparations including recombinant FSH (rFSH).
    Type: Application
    Filed: August 29, 2017
    Publication date: March 22, 2018
    Inventors: Ian Cottingham, Daniel Plaksin, Richard Boyd White
  • INTEGRIN HETERODIMER AND A SUBUNIT THEREOF
    Publication number: 20180079795
    Abstract: A recombinant or isolated integrin heterodimer comprising a novel subunit ?10 in association with a subunit ? is described. The ?10 integrin may be purified from bovine chondrocytes on a collagen-type-II affinity column. The integrin or the subunit of ?10 can be used as a marker or target of all types of cells, e.g. of chondrocytes, osteoblasts, and fibroblasts. The integrin or the subunit ?10 thereof can be used as a marker or target in different physiological or therapeutic methods. They can also be used as active ingredients in pharmaceutical compositions and vaccines.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 22, 2018
    Inventor: Evy LUNDGREN-AKERLUND
  • ANTI-TNF-ALPHA POLYPEPTIDE COMPOSITION AND USE THEREOF
    Publication number: 20180079796
    Abstract: The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of immunogenicity when administered to a subject, as well as a treatment method involving the administration of the composition.
    Type: Application
    Filed: March 11, 2016
    Publication date: March 22, 2018
    Inventors: Jeehoon GHIL, Yoonseok LEE, Songyoung KIM, Orlando A. JAQUEZ, Robert S. GRONKE