Abstract: An electrode for use with a therapeutic current delivery system can include a flexible, water vapor-permeable, conductive adhesive material; a current dispersing element in contact with the conductive adhesive material; and a non-conductive, flexible, water vapor-permeable, electrically-insulating top layer provided in contact with the current dispersing element. The current dispersing element can be conductive at least laterally along a plane of the electrode. The conductive adhesive material can be conductive in a direction substantially orthogonal to the plane of the electrode and semi-conductive in a direction substantially lateral to the plane of the electrode.

Abstract: A system and method for motivating a particle, for example a drug molecule, to a predetermined location in three dimensional space by applying magnetic fields, which may be static or time-varying, to the particle. The magnetic fields may be applied by one or a plurality of magnets, and may be multipole of any order such as octopole or decapole. The electric current driving the magnet coils may be pulsed for inducing a voltage in the molecules to aid in motivation. In an exemplary embodiment of the invention in which the substance is a drug, for example a drug molecule or plurality of drug molecules, the magnets may be positioned outside the body of the person to be treated, and the magnetic field(s), which may be time-varying, are used to motivate the drug molecule(s) to a predetermined location in an animal's body. The animal may be a human.

Abstract: An implantable electrical stimulation lead includes a lead body; terminals disposed along the proximal portion of the lead body; electrodes disposed along the distal portion of the lead body, the electrodes including at least one segmented electrode; and an asymmetric marker disposed along the distal portion of the lead body and including a first ring and a longitudinal band extending longitudinally from the first ring. The asymmetric marker and lead body are formed of different materials that are distinguishable from each other in the radiological images to facilitate radiological determination of the rotational orientation of the lead when implanted. The marker may also include one or more of a longitudinal extension, a second ring, and non-straight longitudinal edges. The marker may also include the longitudinal band and longitudinal extension without a ring.

Abstract: A cochlear implant device includes a flexible electrode array for insertion into a cochlea. The flexible electrode array includes a number of electrodes; a number of electrical wires coupled to the electrodes; and a flexural inflection point positioned on the flexible electrode array such that, when implanted, is situated at a basal turn of the cochlea.

Abstract: An apparatus and method for implanting and securing an implanted medical device in a recipient. The implantable medical device of the generally includes an electrode assembly that comprises an elongate carrier member having at least one stimulating electrode positioned thereon. The carrier member further has a fixation structure positioned thereon configured to interact with a portion of the rigid structure to longitudinally secure the carrier member in the recipient.

Abstract: Apparatus, systems and methods employing contact lens as power source for powering a retinal implant are provided. In an aspect, a contact lens includes a substrate that forms at least part of a body of the contact lens and a circuit disposed on or within the substrate comprising. The circuit includes a power harvesting component configured to receive energy in a first form from an external power source and convert the energy from the first form to a second form and an energy transfer component configured to transmit the energy in the second form to device remote from the contact lens when the contact lens is worn over an eye.

Abstract: A device for electrical stimulation of one or more components of the periodontal complex and surrounding tissue of a tooth, for uses such as reducing orthodontic pain and encouraging tooth movement, has electrodes of a rigid, electrically conductive material in a fixed spatial relationship configured for application to oral mucosa and attached gingiva adjacent to, and along a periodontal ligament of, a root structure of a single tooth. An electrical circuit is configured for electrical connection to the at least two electrodes. The electrical circuit has an output providing a subsensory electrical stimulus comprising a waveform in accordance with predetermined stimulation parameters. After the electrodes are applied to the oral mucosa and attached gingiva adjacent to, and along the periodontal ligament of, a root structure of the tooth, a switch, when activated, activates the electrical circuit to output the electrical stimulus through the at least two electrodes.

Abstract: An ophthalmic stimulator for temporarily constricting a pupil of an eye comprises an irradiation control system, to generate an irradiation control signal; an irradiation source, coupled to the irradiation control system, to generate an irradiation; and an irradiation delivery system, coupled to the irradiation control system, to receive the irradiation from the irradiation source, and to deliver a patterned irradiation to an iris of the eye; wherein the irradiation control system controls at least one of the irradiation source and the irradiation delivery system with the irradiation control signal so that the patterned irradiation causes a temporary constriction of the pupil of the eye, without causing a permanent constriction of the pupil.

Abstract: An electrode structure inserting apparatus includes an electrode structure fixing unit to which the electrode structure is detachably fixed, and a vibration generator connected to the electrode structure fixing unit to vibrate the electrode structure fixing unit in an insertion direction of the electrode structure, and the electrode structure inserting apparatus inserts the invasive electrode structure into a nerve in a biological tissue.

Abstract: Systems, methods, and devices are disclosed for optimizing patient-specific stimulation parameters for spinal cord stimulation. A patient-specific anatomical model is developed based on a pre-operative image, and a patient-specific electrical model is developed based on the anatomical model. The inputs to the electric model are chosen, and the model is used to calculate a distribution of electrical potentials within the modeled domain. Models of neural elements are stimulated with the electric potentials and used to determine which elements are directly activated by the stimulus. Information about the models inputs and which neural elements are active is applied to a cost function. Based on the value of the cost function, the inputs to the optimization process may be adjusted. Inputs to the optimization process include lead/electrode array geometry, lead configuration, lead positions, and lead signal characteristics, such as pulse width, amplitude, frequency and polarity.

Abstract: Aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a housing and a plurality of electrodes arranged with the housing. In addition, one or more of the plurality of electrodes may deliver stimulation energy to modulate L-dopa release.

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

Abstract: A method and system for identifying a rotational orientation of an implanted electrical stimulation lead utilize radiological images of the lead. The lead has an asymmetric marker with a longitudinal band extending around a portion of the circumference of the lead. The method and system includes obtaining radiological images of the lead and using those images to determine a predicted rotational orientation of the lead. The predicted rotational orientation of the lead is then corrected based on at least one parameter of the imaging technique used to generate the image data.

Abstract: Implantable medical systems include implantable medical leads that have magnetic orientation-independent magnetically actuated switches that are placed in the conduction path to the electrode of the lead. Thus, regardless of the orientation of a substantial magnetic field like that from an MRI machine to the lead and switch within the lead, the switch opens when in the presence of that substantial magnetic field. The switch may be placed in close proximity to the electrode such that the opening of the switch disconnects the electrode from the majority of the conduction path which thereby produces a high impedance for RF current and reduces the amount of heating that may occur at the electrode when in the presence of substantial levels of RF electromagnetic energy as may occur within an MRI machine.

Abstract: A system and method for PEMF tissue engineering enhances musculoskeletal tissue stimulation by monitoring treatment for compliance with treatment regimens. A PEMF device includes sensors that detect attributes indicating whether the PEMF device is in use. The PEMF device also includes communication devices that connect it with other devices. The data obtained from the sensors may be used to determine a level of compliance in use of the tissue engineering device with a prescribed treatment regimen for the patient. The data is transferred via a paired UE to a remote server. The remote server stores the data in a database and periodically generates compliance reports. The compliance reports are shared with subscribing access devices including the prescribing physician. The UE pairing with the PEMF device maintains a treatment calendar and dynamically modifies reminders based on current treatment status. The treatment regimen may be updated and sent to the PEMF device.

Abstract: A cardiopulmonary resuscitation (CPR) assisting apparatus, comprising: a gasping-stimulating electrode configured to stimulate the thorax diaphragm to cause a gasping action; and a controller configured to control the stimulation applied by the gasping-stimulating electrode.

Abstract: The present invention relates to an apparatus and a method for treating cancer using a discontinuous fractional alternative electric field, and more particularly, to an apparatus and a method for treating cancer using a discontinuous fractional alternative electric field capable of providing the same treatment effect on tumor while minimizing an effect on normal tissues by reducing time for which an electric field is applied over the existing electric field treatment. According to the exemplary embodiments of the present invention, the discontinuous fractional alternative electric field shows the same effect as applying the continuous electric field to the cancer cells while reducing the effect on the normal cells, and as a result the method for treating cancer using an optimized alternative electric field may be constructed by the treatment using the discontinuous fractional alternative electric field.

Abstract: The present invention is a flexible circuit electrode array for neural stimulation including a polymer base layer, a metal trace layer on the polymer base layer, and a polymer top layer on the metal traces layer, where the metal trace layer forms at least one electrode made of multiple smaller common electrodes connected by electrical traces.

Abstract: An example of a system may include an electrode arrangement and a neuromodulation device configured to use electrodes in the electrode arrangement to generate a neuromodulation field. The neuromodulation device may include a neuromodulation generator, a neuromodulation control circuit and a storage. The storage may include a stochastically-modulated neuromodulation parameter set and the stochastically-modulated neuromodulation parameter set may include at least one stochastically-modulated parameter. The controller may be configured to control the neuromodulation generator using the stochastically-modulation parameter set to generate the neuromodulation field.

Abstract: An electrical neuromodulation system and method of meeting a therapeutic goal for a patient using a neuromodulation device. A modulation parameter value is varied by a step size. The neurostimulation device instructs the neuromodulation device to deliver electrical energy to at least one electrode in accordance with the varied modulation parameter value. A therapeutic feedback indicator is compared to a threshold in response to the delivery of the electrical energy. Whether the therapeutic goal has been met is determined based on the comparison, and the previous steps are repeated to determine the modulation parameter value at the resolution of the step size that minimizes energy consumption of the neuromodulation device required to meet the therapeutic goal when delivering the electrical energy to the electrode(s) in accordance with the varied modulation parameter value.

Abstract: Disclosed are methods of treating depression, mania, post-traumatic stress disorder (PTSD), and various other neurologic conditions using synaptic pathway training. Methods of synaptic pathway training include, generally, achieving a favorable treatment result by activating a synaptic pathway using a pharmacologic agent, such as treating refractory symptoms of depression with ketamine, following by potentiation of the favorable result by repeatedly stimulating the activated pathway. Stimulation of a synaptic pathway may be achieved by intrinsic means, such as performance of cognitive exercised, or extrinsic means, such as by delivery of a sensory stimulus to the patient, placing a potential voltage difference across the brain or a brain region, or by placing the brain or a brain region in a magnetic field.

Abstract: An implantable electronic neuromodulation system includes an implantable pulse generator comprising a controller and a memory. The memory is configured to store an emulated neurosensory signal representative of nerve traffic acquired from a patient equipped with an extra-aortic balloon pump counter-pulsation system or an intra-aortic balloon pump counter-pulsation system. A lead is coupled to the implantable pulse generator. At least one electrode is coupled to the lead. The at least one electrode is positionable in contact with or adjacent to at least one nerve that carries sensory information from baroreceptors. The controller is configured to stimulate the at least one nerve using the emulated neurosensory signal.

Abstract: A controller for implementing a method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, where such arbitrary waveforms can also be used for charge balancing purposes.

Abstract: This document discusses, among other things, systems and methods to provide a sub-perception spinal cord stimulation (SCS) to a patient. Some system examples include a stimulation device configured to deliver electrical stimulation to a patient and a control circuit configured to adjust at least one parameter of the electrical stimulation in response to a feedback signal from the patient.

Abstract: Therapy systems for treating a patient are disclosed. Representative therapy systems include an implantable pulse generator, a signal delivery device electrically coupled to the pulse generator, and a remote control in electrical communication with the implantable pulse generator. The pulse generator can have a computer-readable medium containing instructions for performing a process that comprises collecting the patient status and stimulation parameter; analyzing the collected patient status and stimulation parameter; and establishing a preference baseline containing a preferred stimulation parameter corresponding to a particular patient status.

Abstract: A therapeutic window for at least one electrode of a medical system may be determined based on a volume of tissue expected to be activated (“VTA”) by electrical stimulation delivered by the at least one electrode. In some examples, a processor determines the therapeutic window for a particular electrode by at least determining an efficacy threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the efficacy threshold, and determining an adverse-effects threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the adverse-effects threshold.

Abstract: A neuromodulation system configured for providing sub-threshold neuromodulation therapy to a patient. The neuromodulation system comprises a neuromodulation lead having at least one electrode configured for being implanted along a spinal cord of a patient, a plurality of electrical terminals configured for being respectively coupled to the at least one electrode, modulation output circuitry configured for delivering sub-threshold modulation energy to active ones of the at least one electrode, and control/processing circuitry configured for selecting a percentage from a plurality of percentages based on a known longitudinal location of the neuromodulation lead relative to the spinal cord, computing an amplitude value as a function of the selected percentage, and controlling the modulation output circuitry to deliver sub-threshold modulation energy to the patient at the computed amplitude value.

Abstract: A system for cardiac pacing includes circuitry and at least two electrodes, configured to be placed in contact with a chest of a subject. The circuitry is configured to receive electro-cardiogram (ECG) signals from the at least two electrodes, to identify brachycardia or asystole or ventricular tachycardia in the subject based on the received ECG signals, upon identifying brachycardia or asystole or ventricular tachycardia, to shape a mains electrical source signal into a waveform applicable to a transformer for generating a pacing signal, to generate the pacing signal by applying the waveform to the transformer, and to apply the pacing signal through the at least two electrodes to the chest of the subject.

Abstract: Compliance voltage generation circuitry for a medical device is disclosed. The circuitry in one embodiment comprises a boost converter and a charge pump, either of which is capable of generating an appropriate compliance voltage from the voltage of the battery in the device. A boost signal from compliance voltage monitor-and-adjust logic circuitry is processed with a telemetry enable signal to selectively enable either the charge pump or the boost converter: if the telemetry enable signal is not active, the boost converter is used to generate the compliance voltage; if the telemetry enable signal is active, the charge pump is used. Because the charge pump circuitry does not produce a magnetic field, the charge pump will not interfere with magnetically-coupled telemetry between the implant and an external controller. By contrast, the boost converter is allowed to operate during periods of no telemetry, when magnetic interference is not a concern.

Abstract: Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.

Abstract: A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.

Abstract: An electrical implant or implant system includes an energy supply unit or is connected to an energy supply unit and includes at least one fixing device for permanently fixing the electrical implant or implant system to bodily tissue, or is connected to the fixing device. At least two implant components are releasably mechanically connected to one another. A first of the implant components includes at least parts of the fixing device. A second of the implant components includes an electromechanical component which, as a result of current drain or current feed, can swell in such a way that it causes a swelling at an outer contour of the electromechanical component at least at one point. The electromechanical component is disposed in such a way that a swelling of the electromechanical component results in a separation of the mechanical connection between the first and second implant components.

Abstract: Systems and methods for detecting cardiac arrhythmias such as an atrial fibrillation (AF) are described herein. The AF detection system includes a sensor circuit to sense a physiological signal, a heartbeat processor to recognize a plurality of beat patterns using cycle length of two more consecutive cardiac cycles. The beat patterns can be indicative of temporal relationship between the consecutive cardiac cycles. The heartbeat processor may generate a repetitiveness indictor based on a statistical measurement of various beat patterns. The AF detection system includes an arrhythmia detector to detect an episode of AF based on the repetitiveness indictor, and to discriminate the AF from other arrhythmias of atrio-ventricular conduction abnormalities.

Abstract: The present invention relates to a new method of treating patients with the skin conditions including actinic keratosis and non-melanoma skin cancer using Cold Atmospheric Plasma (CAP).

Abstract: High frequency repetitive magnetic pulses may be used to treat pain in the foot of a person by relaxing the muscle and reducing communication of pain signals by neurons in the treatment region. A device is disclosed, which is floor mounted and incorporates a cooling mechanism and heat sink to allow high frequency magnetic stimulation to the person's foot.

Abstract: Described herein are electromagnetic treatment devices for treatment of tissue. In particular, described herein are lightweight, wearable, low-energy variations that are specifically configured to specifically and sufficiently apply energy within a specific bandpass of frequencies of a target biological pathway, such as the binding of Calcium to Calmodulin, and thereby regulate the pathway. Methods and systems for treating biological tissue are also described.

Abstract: An ophthalmic stimulator for temporarily constricting a pupil of art eye comprises a mobile irradiation control system, to generate an irradiation control signal; an irradiation source, coupled to the irradiation control system, to generate an irradiation; and an irradiation delivery system, coupled to the mobile irradiation control system, to receive the irradiation from the irradiation source, and to deliver a patterned irradiation to an iris of the eye; wherein the mobile irradiation control system controls at least one of the irradiation source and the irradiation delivery system with the irradiation control signal so that the patterned irradiation causes a temporary constriction of the pupil of the eye, without causing a permanent constriction of the pupil.

Abstract: A method of treating a subject afflicted with a retinal degenerative or neurodegenerative disease including administering an optogenetic therapeutic to the subject, where the optogenetic therapeutic includes an optogenetic protein fused or linked to a marker protein. An optogenetic therapeutic for use in treating a subject afflicted with a retinal degenerative or neurodegenerative disease, including an optogenetic protein fused or linked to a marker protein.

Abstract: An ophthalmic stimulator for temporarily constricting a pupil of an eye comprises an irradiation control system, to generate an irradiation control signal; a light source, coupled to the irradiation control system, to generate a light beam; and a beam-shaping optics, coupled to the irradiation control system, to receive the light beam from the light source, and to deliver a light ring to an iris of the eye; wherein the irradiation control system controls at least one of the light source and the beam-shaping optics with the irradiation control signal so that the light ring causes a temporary constriction of the pupil of the eye, without causing a permanent constriction of the pupil.

Abstract: A method for temporarily constricting a pupil of an eye by an ophthalmic stimulator comprises generating an irradiation control signal by an irradiation control system; generating an irradiation by an irradiation source, coupled to the irradiation control system; receiving the irradiation and delivering a patterned irradiation to an iris of the eye with an irradiation delivery system; and controlling at least one of the irradiation source and the irradiation delivery system by the irradiation control signal of the irradiation control system so that the patterned irradiation is causing a temporary constriction of the pupil of the eve, without causing a permanent constriction of the pupil.

Abstract: The invention comprises a method and apparatus for scanning charged particles in a cancer therapy system, comprising the steps of: (1) providing a first and second dipole magnet system and a gap, the gap comprising a common gap length, along a path of the charged particles, within both the first and second dipole magnet systems, the gap comprising a progressively increasing x/y-plane cross-section area from an entrance area of the charged particles into the double dipole magnet system to an exit area of the double dipole magnet system, the x/y-plane perpendicular to a z-axis from a center of the entrance area to a center of the exit area; (2) scanning the positively charged particles along a first axis of the x/y-plane using the first dipole magnet system; and (3) scanning the positively charged particles along a second axis of the x/y-plane using the second dipole magnet system.

Abstract: A multi level multileaf collimator employs leaves with leaf tips having a non-square shape in a beam's eye view to improve beam shaping effect and penumbra performance. The multi level multileaf collimator includes a first multileaf collimator in a first level comprising beam blocking leaves longitudinally movable in a first direction, and a second multileaf collimator in a second level comprising beam blocking leaves longitudinally movable in a second direction. The first direction may be generally parallel with the second direction and the leaves of the first multileaf collimator may laterally offset the leaves of the second multileaf collimator. The beam blocking leaves of the first multileaf collimator may comprise an end portion having a non-square shape in a beam's eye view.

Abstract: A multi-layer charged particle beam characterization system is disclosed, and method for using the same. A typical embodiment includes a plurality of two-sided metal plates, arranged as a stack, each metal plate having an electrical contact tab extending from at least one common edge of the metal plate, and a plurality of insulator films disposed between adjacent metal plates, each insulator film is sized to match its corresponding metal plate. The tabs are coupled to a printed circuit board and connected to an external electrical connector to register a number of metal plates and insulator layers through which a charged particle beam has penetrated.

Abstract: An integrated system for radiation therapy that includes a synchrotron ion accelerator beam delivery system, and imaging system on the same compact rotating gantry is disclosed. An ion accelerator, accelerating charged particles, is mounted on an annular gantry that rotates about the patient to be treated. The charged particles may be protons or other heavier ions such as helium or carbon. The beam delivery system, which includes bending, focusing, and scanning magnets and other equipment for accurately delivering the ion beam to the patient, is integrated on the same rotating structure. An imaging system which in one embodiment is, but not limited to, a cone beam CT system. The accelerator and imaging system may be configured in a coplanar or non-coplanar arrangement with the rotation plane of the gantry and with the beam delivery system to allow for optimization of the size or functionality of the system.

Abstract: Methods and devices are described which allow sound waves to be safely be applied to the eyelid of an eye of a patient or through the eyelid to other structures in the eye or to or through structures in the facial region to effect changes to one or more structures in and around the eye or directly through the cornea or sclera to regions of the eye to treat one or more diseases of the eye.

Abstract: Methods for non-invasive fat reduction can include targeting a region of interest below a surface of skin, which contains fat and delivering ultrasound energy to the region of interest. The ultrasound energy generates a thermal lesion with said ultrasound energy on a fat cell. The lesion can create an opening in the surface of the fat cell, which allows the draining of a fluid out of the fat cell and through the opening. In addition, by applying ultrasound energy to fat cells to increase the temperature to between 43 degrees and 49 degrees, cell apoptosis can be realized, thereby resulting in reduction of fat.

Abstract: Disclosed herein are aromatherapy delivery systems, methods of their use and preparation as well as aromatherapy delivery system kits. The aromatherapy delivery systems depicted herein are suitable for medicinal applications, such as the treatment of common human ailments.

Abstract: The invention relates to a modular, portable, air purifier device capable of supplying filtered or otherwise conditioned airflow to an individual. More specifically, the present invention provides an air purification system that allows for the remote detection and analysis of local ambient air quality and transmit that information to wirelessly connected devices.

Abstract: The present invention relates to a nasal cavity insertion type mask, and the purpose of the present invention is to provide a nasal cavity insertion type mask for filtering various kinds of fine dust contained in external air inhaled through the nose and preventing a respiratory disease by improving an antibacterial effect inside the nasal cavity, when the mask is inserted into the nose and breathing occurs, and the mask inserted into the nasal cavity is configured so as not to be separated from the naval cavity, and is configured to maintain filtering performance and enable an economical use thereof since only a filter can be replaced.

Abstract: A remote overhead anchor for use at an elevated overhead position and adapted to be secured to a horizontally extending structural member. The anchor includes first and second substantially half ring members that are hinged together at their bottoms. The members can move between a closed position wherein they lie in substantially the same plane and an open position wherein the tops are separated from each other so that they lie in different planes. A spring biases the members into the closed position. The tops of the members include cam surfaces arranged such that when said first and second half ring members are moved upwardly and engage a horizontal structural member, the structural member causes the cam surfaces to move away from each other to move the half ring members into the open position. A spring biased lock prevents the half ring members from opening but can be deactivated remotely so that the anchor can be removed by a worker standing on the ground.