Abstract: Devices and methods for establishing aseptic connections between a drug container and a fluid pathway connection for a drug pump are provided. A fluid pathway connection includes a connection hub, a piercing member, a piercing member retainer, and a drug container. The drug container includes a cap, a pierceable seal, and a barrel. The piercing member is at least partially disposed in a sterile chamber defined by the connection hub, and the connection hub is configured to be connected to the drug container while maintaining an aseptic condition of a fluid pathway from the sterile chamber to an interior of the drug container.

Abstract: A fluid flow control valve includes a valve body with a fluid flow lumen therethrough and a valve member located within the fluid flow lumen. At least one of the valve body and valve member is resilient and respectively sized for movement between a normally closed position in which the valve member and a fluid lumen surface are in sufficient annular contact to block fluid flow through the fluid flow lumen and an open position in which at least one of the valve body and valve member flexes to a spaced apart position that allows fluid flow between them. Downstream fluid pressure may contact the valve body to enhance sealing. A fluid absorbent member may also be employed with the valve body. Flow control devices, such as medical fluid injection devices, and methods may employ this valve.

Abstract: An Infusion device (1) for administering a medical fluid to a patient (P) comprises a pumping mechanism (11) for pumping a medical fluid from a fluid container (20) through a delivery line (3) towards a patient (P) at a set flow rate, a sensor device (14) for measuring a force on the pumping mechanism (11) or the delivery line (3), and a processor device (15) for deriving, from the force measured by the sensor device (14), a pressure value indicative of the pressure in the delivery line (3), wherein the processor device (15) is constituted to compare the pressure value to a threshold value for determining whether a occlusion (O) in the delivery line (3) is present.

Abstract: Infusion systems including infusion devices and consumables and related operating methods are provided. An exemplary method of operating an infusion device operable to deliver a fluid influencing a physiological condition to a body of a user involves a control module of the infusion device obtaining calibration data associated with a consumable coupled to the infusion device via an interface of the infusion device, determining a delivery command for delivering the fluid to the body of the user based at least in part on the calibration data, and operating a pumping mechanism to deliver the fluid from a reservoir of the consumable to the body of the user in accordance with the delivery command.

Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

Abstract: In selected embodiments, a handheld injection safety applicator includes an applicator housing with a handle and a retractable needle housed within the applicator. The applicator further includes a first sensor that detects the presence of a user's grip on the handle and a second sensor that detects the presence of an animal. The applicator also includes processing circuitry configured to receive a first signal from the first sensor indicating that the user is gripping the handle and receive a second signal from the second sensor indicating that an animal is detected. The applicator extends the needle out of the applicator into the animal once the first and second signal are received and delivers a dose of medication into the animal once the needle is fully extended into the animal.

Abstract: An auto-injector device for administering a liquid pharmaceutical composition, in which an end-user can select between doses that the device is capable of delivering. The end-user choices that translate into the selected doses can be based on end-user perceived severity of symptoms, end-user weight and other such factors. In some embodiments the auto-injector is configured to administer the one chosen dose only. In other embodiments, the auto-injector can deliver second and subsequent doses up to full dose of the pharmaceutical composition disposed in the injector. The auto-injector can provide visual, audio, and tactile feedback, alone or in combination, to the user to indicate the dose selected, instructions for use, and when the dose has been administered.

Abstract: A sensor device to be attached to a drug delivery device includes an array of conducting elements each forming part of a respective resonant circuit and each operable to have a signal applied to it. The drug delivery device has a first movable element supporting a conductive region, which is configured to move along a path parallel to a longitudinal axis of the drug delivery device. When the sensor device is attached to the drug delivery device, the conducting elements are arranged such that each resonant circuit is operable to output a signal indicative of the proximity of the conductive region supported on the first moveable element to the respective conducting element of each resonant circuit. The sensor device includes circuitry to receive the signals output from the resonant circuit and, based on the received signals, determines information associated with a location along the path of the first movable element.

Abstract: A device for administering an active substance comprises a multi-chamber carpule having a bypass in one wall and at least one first chamber with a solid active substance and a second chamber with a solvent for the active substance, the second chamber being delimited by a first plug arranged distally in the multi-chamber carpule and a second plug arranged proximally therein; a mixing element is rotatably mounted about a rotational axis in relation to the housing and can be rotated about the rotational axis in a rotational direction in order to mix the active substance and the solvent; and a first detent device is provided on the device such that, after the mixing operation, an axial displacement of the distal end of the second plug in relation to the wall of the multi-chamber carpule is blocked in the proximal direction by means of the distal end of the bypass.

Abstract: An injection device (100) for injection of a medicament from a pre-filled container (10) having a container body (12) for containing the medicament, a needle (16) disposed at a distal end of the container body (12), a removable needle shield (30) and a stopper (22) for expelling medicament from the container (100), the device comprising a housing (110) for housing the container (10), a plunger (142) for driving the stopper (22) of the container (10) in a distal direction to expel the medicament, and a priming mechanism having an operating member (152) which is movable with respect to the housing (110). The priming mechanism is arranged to release the needle shield (30) from the needle (16) and to move the container body (12) in a proximal direction with respect to the plunger (142) upon movement of the operating member (152) from a first position to a second position during an operating sequence of the device.

Abstract: A medication injection pen, including a housing, a dose set knob (DSK) comprising an internal thread and an internal key proximate to a distal end of the internal thread, and a dose stop member comprising an external thread engaging the internal thread of the dose set knob. Rotation of the dose set knob to set a medication dose causes lateral translation of the dose stop member with respect to the dose set knob, and when the dose set knob is rotated to a last dose setting position, the dose stop member rotationally abuts the internal key thereby preventing further rotational movement of the dose set knob in a dose setting direction.

Abstract: An injection device is for squeezing out a dosage of injection liquid from a container and includes: a container configured to hold the liquid; a housing defining a longitudinal central axis; first and second components; wherein the first and second component move relative to one another when the liquid is squeezed out; an injection spring configured to at least partially release stored energy to cause the dosage of the liquid to be squeezed out; a setting device to set a rate at which the liquid is squeezed out; the setting device influencing the energy required for moving the second component relative to the first; the first and second component being moveable relative to one another in the direction of the longitudinal central axis when the liquid is squeezed out; and, the setting device, when setting the rate, acting on a rotary position of the first component relative to the second.

Abstract: An injection device has a housing and a metering member held rotatably in the housing and fixed in the direction of a longitudinal central axis. The metering member via a threaded connection is connected to a sleeve held rotationally fixed in relation to the housing and displaceable in the direction of the axis. When setting a dosage, the metering member rotates relative to the housing, and the sleeve moves distally. When dispensing a set dosage, the sleeve moves in the proximal direction, and the metering member by virtue of the threaded connection rotates in the opposite direction. To enable an automatic injection, the device has a spring supported in relation to the injection sleeve via a first end and in relation to the housing via a second end; the spring, when squeezing out liquid, moves the sleeve proximally and on account thereof causes the set dosage to be dispensed.

Abstract: An injection device includes: a housing defining a longitudinal axis; an operating element; a metering member held in the housing so as to be rotatable and fixed in the direction of the axis; the operating element, in a first position for setting a quantity to be dispensed, being mounted so as to be rotatable relative to the housing and rotationally fixedly connected to the metering member via a first coupling; the operating element, in a second position for dispensing, is rotationally fixedly connected to the housing via a second coupling and is rotatable in relation to the metering member; a first latching installation acting between operating element and housing, wherein the first latching installation is effective only in the operating element's first position; and, a second latching installation acting between operating element and metering member, wherein the second latching installation is effective only in the operating element's second position.

Abstract: An injection device having a distal end, and including a needle located inside the injection device in an initial position, wherein the needle is moveable to a puncturing position in which the needle projects from the distal end, an open region located distally relative to the needle in the initial position of the needle and having a dimension, a reduction piece moveable relative to the opening region whereby the dimension may be reduced and a holding member that latchingly connects to the reduction piece and a product container holder.

Abstract: An apparatus for safely detaching a hypodermic needle from a syringe. The apparatus includes a body comprising a head portion, a stem portion; a shield coupled to the stem portion of the body, the shield comprising a base having an aperture shaped and dimensioned to receive a shaft of a hypodermic needle and grip a hub of the hypodermic needle. The apparatus also includes a plunger coupled to the body and moveable relative to the body along a longitudinal axis that passes through the plunger, the body and the shield, the plunger comprising a head and a stem, the stem configured to receive the shaft of the hypodermic needle when the hypodermic needle is inserted into the aperture of the base and the aperture of the base grips the hub of the hypodermic needle.

Abstract: A needle assembly (1) for mounting on an injection device is disclosed comprising: a main body (10) which is removably attached to an injection device in use; a needle (90) secured in the main body and having a forward portion which projects forwardly from the main body. The needle assembly further includes a shield (50) which is slideably mounted within the main body (10) and an actuator portion (70) which extends outside the main body and is configured for pushing the shield (50) forward manually in use. The shield (50) is slideably moveable between a first position in which the forward portion of the needle (90) projects forwardly of a shield cavity (64), and a second position in which said forward portion of the needle is located within the shield cavity (64).

Abstract: A needle set includes a needle guard with upper and lower jaws each defining a channel and joined at a hinge. Each edge of the jaws is aligned with and spaced from a respective edge of the opposite jaw defining slots alongside walls of the jaws. A winged needle has a cannula, a hub with a pair of wings with a tube connected to the cannula by the hub. The hinge portion has an opening into which the tube is received, and the side walls are spaced apart to permit the hub to be received between the jaws with the wings in the slots. The slots progressively narrow to a first spacing that is narrower than a thickness of each wing at a point thereof, and thereafter expand linearly to a second spacing that is substantially equal to the thickness of the wings.

Abstract: According to various embodiments, a method and system to obtain access to a blood vessel underneath a skin layer that may preserve lifespan of the blood vessel and reduce executional skill variability may be provided. The method includes placing a guiding portion between the blood vessel and the skin layer; and configuring the guiding portion to receive and guide a needle to reach the same location of the blood vessel repeatedly and consistently; and forming a resultant scarred track between the blood vessel and the skin layer as the guiding portion is resorbed over time. The system includes a vascular access device configurable to first possess strength to penetrate through a tissue layer, subsequently possess flexibility to conform to the surrounding tissue beneath the tissue layer; and a guiding portion which may be resorbable, wherein the inlet includes a larger diameter compared to the outlet.

Abstract: A rectal injection device and a method of operating a rectal injection device. In one embodiment, the device includes: (1) a handle having a trigger associated therewith, (2) an extension tube extending from the handle and terminating in a head, (3) at least two needles coupled to the head and configured to move relative thereto between a retracted position and a deployed position and (4) a pullrod coupling the trigger and the needles and configured to cause the needles to move.

Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

Abstract: A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

Abstract: A surgical gas delivery device includes a filter cartridge interface and a computer controlled control unit configured to control the circulation of surgical gas during endoscopic surgery. The control unit can operate in a plurality of different modes of operation. A tube set for connecting the surgical gas delivery device to one or more end effectors includes a filter cartridge in fluid communication with the tube set. The filter cartridge is seated in the filter cartridge interface of the surgical gas delivery device to communicate surgical gas between the surgical gas delivery device and the one or more end effectors. The surgical gas delivery device includes a reader operatively connected to receive input from a data carrying element of the tube set. The data carrying element, reader, and control unit can launch a specific one of the modes of operation when the filter cartridge is inserted.

Abstract: An evacuation system for continuously removing gas from a body cavity of a patient during an endoscopic surgical procedure is disclosed, which includes an inlet flow path leading to a first trocar communicating with the body cavity through which an essentially continuous flow of gas is delivered to the body cavity, an outlet flow path leading from a second trocar communicating with the body cavity though which an essentially continuous flow of gas is removed from the body cavity, a pump communicating at least with the outlet flow path for removing an essentially continuous flow of gas from the surgical cavity, and a processor operatively associated with the pump for controlling at least the essentially continuous flow of gas from the body cavity.

Abstract: A surgical apparatus includes: a pipe sleeve section through which gas can circulate; a first seal section provided on a proximal end side of the pipe sleeve section; a second seal section provided on an insertion opening side of the pipe sleeve section; and a sheath provided with, between the first seal section and the second seal section, a hole portion through which gas circulates.

Abstract: A dose counter for a metered-dose inhaler (MDI) has an actuator housing and canister with an activation valve at a valve end of the canister. The dose counter includes a circuit assembly having a substrate with at least a first and a second switch thereon. The first and second switches are sized and positioned to interact with the valve end of the canister when the canister moves from a rest position to an activation position, such that the first switch is triggered when the canister reaches a first longitudinal position and the second switch is triggered when the canister reaches a second longitudinal position that is offset from the first longitudinal position during movement of the canister from the rest position to the activation position. A counting circuit is configured to receive a signal from the first and second switches and to determine when the metered dose inhaler is activated.

Abstract: A hand-held dose-dispensing pressurized spray inhaler includes a housing, an aerosol canister in the housing having a canister body and a movable valve stem biased to extend therefrom, a fixture stationarily supporting the valve stem relative to the housing, and an actuation mechanism partially fitting over the canister body opposite from the valve stem such that only together with the fixture the canister body is supported in the housing with a clearance gap between the canister body and the housing and for movement relative to the housing and toward and away from the valve stem and fixture. The actuation mechanism provides a child restraint capability requiring two unlocking actions be carried out to convert it from a locked to an unlocked condition before it can move the canister body relative to the housing and valve stem to release a dose of pressurized spray from the valve stem.

Abstract: An adapter for fitting to a drug delivery device, the adapter including: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of the drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. A drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.

Abstract: A nebulizer is proposed which comprises a blocking device for blocking opening of the nebulizer in a tensioned state. The nebulizer comprises preferably an indicator device for indicating a tensioned state of the nebulizer. The nebulizer comprises further a depressable actuator member at a housing part which is detachable from the nebulizer.

Abstract: Vaporization element, device and method for vaporizing phyto material. A hollow member defining a fluid pathway is positioned proximate a heating element with a phyto material contact surface. An electrical heater is positioned on the opposite side of the phyto material contact surface. Phyto material or extract deposited on the phyto material contact surface can be vaporized by heat from the electrical heater. The vapor can enter the fluid pathway and pass through the hollow member to an inhalation aperture. The electrical heater may be powered by an electrical power source provided in a support unit. The hollow member can be mounted to a vapor processing device that cools and/or filters the vapor before it reaches the inhalation aperture. The support unit may have securement mechanisms to attach the vapor processing device to the vaporization device.

Abstract: A vaporizer pen for heating and vaporizing a liquid product that is ingested by a user has an outer hollow tube with a proximal end and a distal end and an inner hollow tube within the outer hollow tube having a proximal end and a distal end. The inner tube defines a chamber inside. A mouthpiece abuts the proximal end of the outer hollow tube and an atomizing chamber is positioned within the outer hollow tube and abuts the distal end of the inner hollow tube. A porous stone has a proximal stone end and a distal stone end and is configured to retain the liquid product. The porous stone is positioned within the hollow inner tube and the distal stone end is in contact with the atomizing chamber. A heating element is in communication with the atomizing chamber and is constructed of a ceramic material.

Abstract: A ventilation drive (10) for an anesthesia device and a method for operating such a ventilation drive (10) are provided. The ventilation drive includes a blower unit (12), a pressure chamber (14) and a flexible bag (16) located in the pressure chamber (14). An internal volume of the bag (16) is coupled to an inspiratory branch (20) of a ventilation line. The blower unit (12) can be coupled to the internal volume of an outlet side and to an air inlet (26) for feeding ambient air on an inlet side. Further, a flow sensor (36) is provided between the outlet side of the blower unit (12) and the pressure chamber (14).

Abstract: Various systems, apparatus and methods are described herein for generating cardiac, cardiopulmonary, and/or hemodynamics phenotypes of patients for use in various applications. In various embodiments, a ventilation support apparatus connected to a patient may be operated to perform a therapeutic maneuver selected to cause one or more targeted receptors of the patient to initiate an autoregulation response in the patient. In various embodiments, a measurement may be taken of one or more changes in a vital sign of the patient such as blood pressure that is caused by initiation of the autoregulation response in the patient. In various embodiments, a cardiac, cardiopulmonary, or hemodynamic phenotype of the patient may be generated based on the measured one or more changes.

Abstract: Disclosed is a ventilator comprising a ventilation device which produces a respiratory gas flow for ventilating at least one patient and sets the respiratory gas flow to at least one ventilation pressure depending on at least one respiratory phase of the patient. Provision is made of a monitoring device which is suitable and configured for monitoring a synchronicity between respiratory phase and target ventilation pressure and, to this end, capturing a characteristic signal for the ventilation pressure and a characteristic signal for the respiratory phase of the patient and comparing the two signals to one another and determining a characteristic for the synchronicity on the basis of the comparison.

Abstract: A control system of a respiratory device for the at least supportive-partial artificial respiration of patients, in particular human patients, comprising a respiratory gas conduit arrangement, a pressure changing arrangement for changing the pressure of respiratory gas in the respiratory gas conduit arrangement during the respiratory operation of the respiratory device, and the control system for controlling the respiratory operation of the respiratory device. The control system has a data input for transmitting operational or/and patient data to the control system. The control system is configured to determine a respiratory operating parameter for the operation of the respiratory device selectively by means of a predetermined first data relationship or by means of a predetermined second data relationship that is different from the first data relationship.

Abstract: A system for facilitating an endotracheal intubation may include a video laryngoscope (VL) apparatus and an intubation device guidance system integrate with or separate from the VL apparatus. The VL apparatus may include a VL body and a video camera. The intubation device guidance system may include one or more magnetometers arranged relative to the video laryngoscope body and configured to generate magnetometer signals based on an interaction with one or more magnetic elements associated with an intubation device. The intubation device guidance system may also include a processor communicatively coupled to the one or more magnetometers and configured to calculate position information regarding the intubation device relative to the video laryngoscope apparatus based on the magnetometer signals. An information output device may be provided to output information to a user indicating or based on the calculated position information regarding the intubation device.

Abstract: Patients undergoing general anesthetics frequently experience emergence clenching where the patient may bite onto their breathing tube and may clench their teeth. These activities lead to dental damage and negative pressure pulmonary edema. The invention of this patent is a simpler, better bite block that may be used to prevent these injuries. The bite block presented comprises a deformable material used as a core around which a bite-resistant material is wrapped to prevent damage to the core by patient biting. The bite-resistant material may be formed into a distal tail that the user can pull to retain or retrieve the device. It may also have a patch of adhesive to attach the bite block to locations including the patient, the surgical drapes and the patient's breathing airway, and thereby prevent loss of the bite block.

Abstract: Component of a patient interface, particularly a cushion, comprising a first part and a second part, wherein the second part is made of a foamed material which is foamed-on the first part. A Method and tool for manufacturing a component of a patient interface, particularly a cushion, comprising the steps molding a first part of the component and foaming a second part on the first part.

Abstract: A nasal cannula for use in a system for providing a flow of respiratory gases to a user is described. The nasal cannula comprises a body made from a pliable material. The body has an inlet and at least one nasal prong fluidly connected to the inlet. In use a conduit providing a flow of gases to the cannula is connected to the inlet, and the nasal prong is inserted into a user's nostril. The cannula is arranged to direct the flow of gases from the nasal prong towards the front wall of the user's nasal passage within the user's nose.

Abstract: In one embodiment, a nasal cannula is shaped to fit within a user's nares, where the nasal cannula includes at least one prong allowing high flow delivery of humidified gases and creates positive airway pressure in the patient's airway. The prongs have angled ends such that, in use, gases flowing through the prongs are directed to the user's nasal passages. The nasal cannula body is partially swivelling and preferably has a ball joint connector.

Abstract: The invention relates to providing novel functions to the double lumen breathing circuits and coaxial breathing circuits which at present do not comprise water traps, by adding a closed system water trap designed to have an inkwell shape and a lung pressure measurement port to said circuits wherein the fluid collected in the bottle section can be discharged without having to open the bottle by means of a drainage luer port located at the base of the bottle and a needleless apparatus that has been inserted into the port, and an injector.

Abstract: A fluid trap is disclosed herein. The fluid trap has a tube connector defining a first interior passageway and a second interior passageway. The tube connector is adapted for connection with a dual lumen tube such that the first interior passageway is in fluid communication with one of the dual lumen and the second interior passageway is in fluid communication with the other of the dual lumen. The fluid trap also includes a reservoir operatively connected to the tube connector. The reservoir is in fluid communication with only one of the interior passageways, and is configured to retain fluid from that passageway.

Abstract: Disclosed herein is a gas delivery and monitoring apparatus that can be used, for example, to deliver oxygen and monitor exhaled carbon dioxide in a subject while under anesthesia. One advantage of the disclosed apparatus is the ability to deliver oxygen directly to the back of the mouth instead of in front of the face. Another advantage of the disclosed apparatus over existing nasal cannulas is the ability to capture carbon dioxide exhaled from both the nose and mouth.

Abstract: A nasal respiratory delivery device includes fabric pads or fabric domes that cover the nostrils and includes a plastic strip with skin-sensitive adhesive for attachment of the device to the septum and the outside of each nostril, and provides for suppressing the human cough via moistening and warming inhaled air, thus soothing the respiratory passageways and mitigating the cough reflex. The nasal respiratory delivery device also provides for cough suppressants, nasal decongestants or other medical or breathing treatments. The nasal respiratory delivery device is placed across both nasal openings and adhered to the nasal septum and to the tissue surrounding the nostrils. The fabric pads or fabric domes are composed of nonwoven or woven manmade and/or natural materials that absorb and provide moisture or therapeutic agents during the act of breathing.

Abstract: In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.

Abstract: Methods and apparatus for modulation of the central nervous system, and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations in the brain. Also described are methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and adjusting the treatment protocol to improve the therapeutic effect of the stimulus or stimuli.

Abstract: An apparatus includes a first acquisition unit acquiring head position information indicating a user's head movement, a second acquisition unit acquiring stimulus information relating to a stimulus input to visual and vestibular sense. A generation unit that generates sound data of sound effect generating movement of a body which reduces sickness based on the head position information and the stimulus information, and calculates a variation amount of the user's head position based on the head position information, calculates an estimation amount for a magnitude of the stimulus input to at least any one of visual and vestibular sense based on the stimulus information, calculates sickness feeling intensity based on the variation amount and the estimation amount, calculates a reduction amount for calculating a feature amount of the sound data based on the sickness feeling intensity, and calculates a feature amount of the sound data based on the reduction amount.

Abstract: A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS).