Abstract: A blood flow analysis device includes a blood vessel region extraction unit that extracts a blood vessel region from a three-dimensional medical image of a subject including a blood vessel, and a blood flow simulation unit that obtains a line resistance by multiplying a resistance value corresponding to a branch blood vessel branching out of the blood vessel region by a surface area of each of preset sections into which the blood vessel region is divided in an extension direction, generates a vascular network model by applying the line resistance to each node of a surface of the blood vessel region, and performs simulation of a blood flow by using the vascular network model.

Abstract: A method and system for determining fractional flow reserve (FFR) for a coronary artery stenosis of a patient is disclosed. In one embodiment, medical image data of the patient including the stenosis is received, a set of features for the stenosis is extracted from the medical image data of the patient, and an FFR value for the stenosis is determined based on the extracted set of features using a trained machine-learning based mapping. In another embodiment, a medical image of the patient including the stenosis of interest is received, image patches corresponding to the stenosis of interest and a coronary tree of the patient are detected, an FFR value for the stenosis of interest is determined using a trained deep neural network regressor applied directly to the detected image patches.

Abstract: The invention relates to a method, system and program product to obtain R-R-intervals. The described herein wearable device is intended for recording the electrical signal caused by the work of the heart. The signal which is a potential difference is recorded from the one hand, by two dry electrodes relative “reference” electrode. This method allows to record the signal in motion. The accuracy of the R-R-intervals values calculated by using this method is sufficient for HRV analysis. The method comprises the following steps: registration of the ECG signal, amplification, filtering, AD-conversion, R-peak detection and the calculation of R-R-intervals. The resulting array of data is stored in device Flash memory and transmitted via wireless communication to a mobile device. Using the application installed on the mobile device and the R-R-intervals array HRV analysis is performed for example to analyze and assess the emotional state of the user.

Abstract: A method of monitoring a subject includes detecting subject head motion information via a microelectromechanical systems sensor associated with an earpiece worn by the subject, processing, via a processor associated with the earpiece, the head motion information to determine subject head displacement relative to an origin and to determine if the subject has fallen down and/or is not moving, and transmitting the processed head motion information to a remote device. The method further includes communicating corrective action to the subject from the remote device and/or communicating corrective action for the subject from the remote device to a third party. The earpiece may include an audio headset, a hearing aid, or an earpiece fitting.

Abstract: A wearable monitoring device configured to be attached to a subject includes at least one physiological sensor configured to identify the subject and to detect and/or measure physiological information from the subject, at least one motion sensor, at least one battery, digital memory storage, at least one processor, and at least one transceiver. The at least one transmitter communicates sensor data from the at least one physiological sensor and the at least one motion sensor with at least one remote device and receives targeted advertisement information from the at least one remote device. The targeted advertisement information is generated by processing the sensor data from the at least one physiological sensor and the at least one motion sensor.

Abstract: In order to obtain a new index value clearly indicating a state of blood circulation, the present invention is characterized by comprising: performing multiple measurements of the blood flow rate in a biological tissue over time; calculating the slope of change over time in the measured blood flow rate; and displaying the value of the calculated slope.

Abstract: Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction, resulting in unacceptable signal to noise ratio (SNR). To overcome this limitation, a novel OCT angiography technique based on the decorrelation of OCT signal amplitude due to flow was created. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion noise. Inter-B-scan decorrelation can be determined using the narrower spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range.

Abstract: A device and a method for assessing the likelihood of an imminent occurrence of cardiac arrest. The device comprises an optical sensor for monitoring the heart rhythm of a person. A Machine Learning Algorithm such as the Artificial neural network (ANN) algorithm analyse features from a trending of pulse intervals in the person's heart rhythm in real time to make the assessment. The device is provided in wearable form, such as a wrist worn device.

Abstract: Systems and methods for monitoring physiological parameters such as intracranial pressure (“ICP”), intracranial temperature, and subject head position are provided. In some embodiments, an implantable apparatus for measuring ICP can be implanted into a subject skull. The apparatus can comprise an implant body having a hermetically sealed chamber housing a gas at a reference pressure, and a pressure conduction catheter having a proximal end and a distal end, wherein the distal end is configured to extend into the brain through a burr hole in the skull and includes a plurality of ports. A barrier can cover the ports of the distal end of the pressure conduction catheter, wherein the barrier and pressure conduction catheter are filled with a number of gas molecules so that the barrier is not in tension in a predefined range of ICPs. The ports may also be configured such that a barrier is not necessary.

Abstract: A magnetism measuring apparatus includes: a sensor array configured to detect magnetic fields generated by a living body; a current source reconfiguration unit configured to reconstruct a current source of a current flowing inside of the living body based on a magnetic field signal obtained from the sensor array. The sensor array includes first sensors configured to detect magnetic field components of many directions and second sensors configured to detect magnetic field components of directions fewer than those of the first sensors.

Abstract: A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. The stimulation electrode may be a connection or self-contained component to contact a portion of a nerve. The stimulation electrode may provide or receive a signal to and/or from the nerve to assist in testing integrity of the nerve.

Abstract: A system and method for secure physiological data acquisition and storage. An identifier of a physiological monitoring patch is obtained by a programming wand, the patch configured to store the identifier within a cryptographic circuit. A password for accessing physiological monitoring data collected using that patch is generated based on at least a portion of the identifier, the password is encrypted using a secret key, and the encrypted password is loaded into the cryptographic circuit. The key is loaded onto a monitor recorder that couples with the patch and obtains the physiological monitoring data using the patch, wherein the monitor recorder offloads the data together with the identifier and the decoded password. The identifier and the password are reported to a server that stores the offloaded physiological monitoring data using the identifier within a secure database and grants access to the data upon receipt of the decoded password.

Abstract: A method, consisting of presenting on a display screen a graphical image of a heart of a patient, including icons representing a catheter that is positioned within the heart and an electrode on the catheter, while the electrode is in contact with tissue at a location in the heart. The method further includes acquiring, using the electrode, electrical signals from the tissue at the location, and processing the acquired signals so as to detect an occurrence of a predefined signal feature in the acquired signals. The method also includes, upon detecting the occurrence of the predefined signal feature, modifying a visual feature of at least one of the icon representing the electrode and the icon representing the catheter on the display screen.

Abstract: An apparatus includes a sensing circuit configured to generate a sensed physiological signal representative of cardiac activity of a subject, and an arrhythmia detection circuit. The arrhythmia detection circuit is configured to monitor information corresponding to ventricular depolarization (V-V) intervals using the sensed physiological signal; determine a V-V interval distribution; determine a heart rate density index (HRDI) as a portion of samples of the V-V interval distribution corresponding to a V-V interval occurring most often in the distribution; and generate an indication of atrial fibrillation (AF) using the HRDI.

Abstract: Systems and techniques for managing biological signals. In one implementation, a method includes receiving a cardiac biological signal that includes information describing events, determining a merit of each event based on one or more of a severity of a cardiac condition associated with the event and a quality of the event, and handling a subset of the events that meet a merit criterion. The subset can be handled for medical purposes.

Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

Abstract: A monitoring device (e.g., a ECG monitor or a Holter monitor) employing an electrocardiograph (40), and an ECG quality controller (50). In operation, the electrocardiograph (40) derives an electrocardiogram from one or more ECG leads (30) upon a connection of the electrocardiograph (40) to the ECG lead(s) 30 (e.g., electrode based or pad/paddle based). In response to the connection of the electrocardiograph (40) to the ECG lead(s) (30), the ECG quality controller (50) controls separate evaluations of a high-frequency noise level (e.g., a degree of muscle artifact and/or a degree of electrode motion artifact within the electrocardiogram) and a low-frequency noise level (e.g., a degree of baseline wander by the electrocardiogram) of an individual ECG lead (30) on an electrocardiogram segmentation basis (e.g., a continual ECG recording divided into segments of a specified duration).

Abstract: A method can include storing input electrical signal data representing at least a given electrophysiological signal acquired from a patient. A non-local mean filter can be applied to the given electrophysiological signal, the non-local mean filter including a spatial filter component and an intensity filter component. The method can also include controlling parameters to establish weighting of each of the spatial filter component and the intensity filter component in response to a control input. Filtered signal data can be stored based on the applying and the controlling.

Abstract: Embodiments relate to non-invasive medical devices, systems and methods for the identification or detection of coronary artery disease, or other anatomical or physiological conditions. In an embodiment, a handheld coronary artery disease (CAD) detection device is used in a non-invasive manner to determine whether an internal coronary artery blockage or other condition is present. In an embodiment, a data transfer system comprises a handheld data collection device or other data collection device, and a networked or local computing system for storing and processing the recorded data. Supplemental devices, such as a tablet, can facilitate use, operation and data transfer between the data collection device and networked or local computing system.

Abstract: A system for configuring an ambulatory medical device includes a medical device configured to monitor a patient for an occurrence of one or more cardiac events, and a remote computing device. The remote computing device is configured to receive threshold values related to operation of the medical device from, for example, a physician, the threshold values identifying conditions indicative of an occurrence of a cardiac event. The remote computing device can query a master lookup table to determine a lookup code associated with the received threshold values and encode a key including the lookup code. Upon activation of the medical device, the remote computing device can establish a communication link with the medical device and transmit the encoded key to the medical device. The medical device can decode the lookup code, identify the threshold values on a local lookup table, and operate according to the identified threshold values.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: A magnetic fluid detecting device (1) that detects magnetic fluid that has been injected into a living body has a detector (2) that detects magnetic fluid in the body when it is in contact with or adjacent to the body, an output device (3) that outputs the detection results in a prescribed output form, a controller (4) that controls the output device (3) based on the detected value inputted from the detector (2), and a power supply module (5) that supplies power to the detector (2), output device (3) and controller (4), using a battery B as the power source. The detector (2), output device (3), controller (4) and power supply module (5) are integrated to allow holding with one hand.

Abstract: A device, system, and method for mapping myocardial tissue, such as epicardial tissue on the right ventricle. A system for mapping myocardial tissue may include a mapping device having a distal portion that includes a distal assembly sized and configured to be positioned within the pericardial space. The distal assembly may include an expandable shell, at least one inflatable or expandable element within the expandable shell, and a mapping electrode assembly. Inflation or expansion of the at least one inflatable or expandable element, and therefore expansion of the expandable shell, within the pericardial space may provide sufficient force of the mapping electrodes against the myocardial tissue being mapped. The system may also include a delivery sheath with a retention element for controllably retracting the device within the sheath during delivery and removal of the device from the pericardial space.

Abstract: The present disclosure relates to a transfer table assembly suitable for use in association with an MR scanner. The transfer table assembly includes a transfer table attached to a transfer table base that may releasably engage an incubator. The transfer table may be dimensionally constructed such that it may be inserted directly into an MR scanner.

Abstract: Representative apparatus, method, and system embodiments are disclosed for non-invasive detection an ingested battery or magnet in a human or other animal subject. The various apparatus embodiments include one or more Hall effect sensors, arranged in a hand-held embodiment or arranged along a flexible strip having an adhesive. A calibration may be determined or reference or calibration field measurements may be generated. A flexible strip is arranged, or the hand-held embodiment is moved, over the esophagus of the subject to generate target magnetic field measurements. The presence of an ingested battery or magnet is detected when one or more target magnetic field measurements (or gradient) is or are greater than or equal to a first predetermined threshold, or when a sign reversal occurs for a difference between target and reference measurements. The various apparatus and system embodiments may also include a monitor for signal processing and display of results.

Abstract: An intravascular device, such as a stylet or catheter, having a flexible, atraumatic tip is disclosed. The intravascular device includes an elongate member having a proximal end, a distal end, and an inner lumen extending between the proximal end and the distal end; a ring electrode disposed at the distal end of the elongate member; an ultrasound sensor disposed at a distal end of the ring electrode; and a first electrical conductor configured to convey an electrocardiogram signal from the ring electrode to a processor. The first electrical conductor may comprise a tapered distal segment or a braided segment.

Abstract: A server has a communicator, a decision unit, and a communication control unit. In a case in which a first condition and a second condition are satisfied, the decision unit decides to cause a first client to stop data transmission. In a case in which the first condition and a third condition are satisfied, the decision unit decides to cause a second client to stand by for the data transmission. The first condition indicates that an access point to which the first client is being connected is the same as an access point to which the second client is being connected. The second condition indicates that a priority of the first client is lower than a priority of the second client. The third condition indicates that priority information has not been received from the second client.

Abstract: The invention relates to a respiratory flow sensor (11) comprising a flow tube (12) which has a flow channel (13) and tube connections for tubes at the free ends (15, 17) of the flow tube, a cover flap (32) which is arranged in the flow channel (13) and divides the flow channel (13) into a first flow channel section (18) and a second flow channel section (19), and comprising connections (22, 23) which open into the flow channel (13) on both sides of the cover flap (32) and which are used to decrease the pressure difference generated by the cover flap (32). A drainage device (41) which comprises drain grooves (42, 43) is provided in the flow channel (13), and the cover flap (32) has a hinge region which is formed by a first slot and a second H-shaped slot.

Abstract: Disclosed are devices comprising a porous sorptive tab and a substructure, such as a face mask, for collecting breath aerosol from a subject. The device is configured such that, in use, a subject breathes onto or through the sorptive tab. Also disclosed are specific methods of analyzing breath aerosol from a subject.

Abstract: Embodiments described herein are directed to non-invasive detection of peripheral arterial disease. For example, a measuring apparatus is used to measure a patient's calf circumference. The measuring apparatus has text feature(s) or indicator(s) printed thereupon that indicate the likelihood that the patient has peripheral arterial disease based on the measured calf circumference. The assessment may be further refined by using a software application that assesses the likelihood of the patient having peripheral arterial disease using at least the calf circumference measurement, along with other information/data. Based on the assessment, a healthcare practitioner may prescribe a walking program for the patient to follow. A software application may track compliance of the walking program and provide escalating reminders to the patient if the patient continues to fail to comply with the prescribed walking program.

Abstract: A medical device can include an elongate shaft extending along a shaft longitudinal axis, which can include a shaft proximal end and a shaft distal end. A force sensor can be disposed on the shaft distal end and can include a sensor proximal end and a sensor distal end. A tip can be disposed on the sensor distal end. A tubular moisture barrier can define a barrier lumen, wherein the tubular moisture barrier extends along the shaft longitudinal axis between the shaft distal end and the tip, and wherein the force sensor is disposed within the barrier lumen.

Abstract: A wearable electronic device and an emotion monitoring method are provided. The wearable electronic device includes: a physiological data monitoring sensor configured to acquire current physiological state data of a wearer in real time; a data memory configured to pre-store physiological state data of the wearer in a preset emotional state; a first comparator configured to compare the current physiological state data acquired by the physiological data monitoring sensor with the pre-stored physiological state data, so as to determine whether or not the wearer is currently in the preset emotional state, thereby to acquire a first comparison result; and an instruction generator configured to generate an emotional monitoring output instruction in accordance with the first comparison result.

Abstract: Provided herein are patient mobility assessment devices having a mobility assistance device with an incorporated distance tracker for use in assessing the ambulation of a recovering medical patient. The distance tracker can be integrated into or removably attached to the mobility assistance device. The information obtained may be displayed on the mobility assistance device and/or at a nurse's station or other remote location for convenient monitoring of patient ambulation. Also provided herein are methods for evaluating patient ambulation using the mobility assessment device and optionally, provision of therapeutic ambulation protocols to a display on the device to assist with patient physical therapy and recovery.

Abstract: Provided is a new method of measuring an amount of movement of an animal. A measurement value of an animal as a measuring target is sequentially measured with a scale (21), an amount of change in the measurement value obtained in chronological order is calculated, and from division of the amount of change in the measurement value by a weight of the animal, an amount of movement of the animal is measured. Accordingly, weight differences between individual living bodies and in the process of breeding are eliminated, and an amount of movement of an animal based on changes in the weight of the living body can be measured.

Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device.

Abstract: Presented herein is a handheld analyte measurement device. The analyte measurement device includes one or more software applications to help the user manager their diabetes. Embodiments and descriptions of the various applications are provided below in conjunction with the handheld analyte measurement device.

Abstract: A device to extract physiological information has at least one laser emitter. At least one optical detector is used to detect a change in optical power absorption. The laser emitter and optical detector are wire bonded into a chip scale module.

Abstract: Provided are a processor device, an endoscope system, and an image processing method capable of discovering not only a lesion in which scattering particles according to a specific scattering model are present but also various lesions. A processor device 16 includes an image acquisition unit 54 that acquires images of three wavelength ranges of a blue wavelength range, a green wavelength range, and a red wavelength range; a scattering characteristic amount calculation unit 71 that calculates a scattering characteristic amount representing a scattering characteristic of an observation object, using the images of the three wavelength ranges; and an image generation unit 74 that generates a scattering characteristic amount image representing a distribution of the scattering characteristic amount.

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

Abstract: The present disclosure provides a device for collecting a bodily fluid sample of a subject for nucleic acid amplification, a method for collecting a bodily fluid sample of a subject for nucleic acid amplification, and a kit for nucleic acid amplification. The device may comprise a device body that is coupled to at least one collection channel including a collection member having an opening at an end thereof to permit flow of the bodily fluid sample from a source thereof to the collection channel. The collection channel may be substantially free of an anticoagulant. The device may further comprise a mechanical member coupled to the device body. The mechanical member may actuate the collection member to (i) extend away from the collection channel for collection of the bodily fluid sample from the source thereof, and (ii) retract into the collection channel upon collection of the sample.

Abstract: The present disclosure provides a system for collecting and/or processing a bodily fluid sample of a subject, a method for collecting and/or processing a bodily fluid sample of a subject, and a kit for collecting and/or processing a bodily fluid sample of a subject.

Abstract: Disclosed is an improved system and method for accessing blood in a flash chamber of an intravenous catheter insertion device. The improved device is mounted on the outside surface of the intravenous catheter insertion device and carries a plunger which moves within the barrel of the device to push on the flash chamber to compress the flash chamber and expel blood through a needle coupled to the flash chamber. Various sizes and/or shapes for the plunger may be provided to accommodate different instances of intravenous catheter insertion devices, and one plunger may be chosen based on a characteristic of the insertion device (e.g., for example, the size or shape of the barrel). This device accommodates other variables in such intravenous catheter insertion devices, such as different kinds of flash plugs (removable/non-removable).

Abstract: A viewing state detection device (6) is configured to include an image input unit (11) to which temporally consecutive captured images including an audience and information on the captured time of the captured images are input, an area detector (12) that detects a skin area of the audience from the captured images, a vital information extractor (13) that extracts vital information of the audience based on time-series data of the skin area, a viewing state determination unit (17) that determines the viewing state of the audience based on the vital information, a content information input unit (14) to which content information including at least temporal information of the content is input, and a content viewing state storage unit (19) that stores the viewing state in association with the temporal information of the content.

Abstract: A feedback device for measuring balance related information, and for producing a stimulation of the skin that encodes that information in a way that is useful to the wearer of the device. At least one sensor detects balance information and transmits at least one balance information signal to a signal processing subsystem. The signal processing subsystem converts the received balance information signal into at least one stimulation control signal. The signal processing subsystem then transmits the stimulation control signal to at least one stimulator, which provides stimulation to a wearer of the device reflecting the stimulation control signal received from the signal processing subsystem.

Abstract: A swallowing movement monitoring sensor which measures swallowing movement of a subject includes an outside shape variation sensor attached to a laryngeal portion of the subject and a microphone attached in an ear of the subject. The outside shape variation sensor includes an optical fiber sheet. The optical fiber sheet detects variation in quantity of transmitted light based on a loss caused by a lateral pressure applied to an optical fiber from the laryngeal portion in association with variation in outside shape of the laryngeal portion involved with swallowing movement. The microphone detects swallowing sound produced in the ear in association with swallowing movement.

Abstract: Under one aspect, a method of displaying medical information about a subject having a plurality of regions includes: resolving light obtained from each region of the plurality of regions into a corresponding spectrum; selecting a portion of each spectrum, the selected portion including medical information about the corresponding region; constructing an image based on the selected portion of each spectrum; and projecting the image onto the subject. Under another aspect, a method of displaying medical information about a subject that has a plurality of regions includes: resolving light obtained from each region of the plurality of regions into a corresponding spectrum; selecting a portion of each spectrum, the selected portion including medical information about the corresponding region; constructing a spectral image based on the selected portion of each spectrum; displaying an image of the plurality of regions; and displaying the spectral image overlying the image of the plurality of regions.

Abstract: A computer-implemented method estimates sleep quality of a user. A related computer system, a computer program product, and a data structure are also described.

Abstract: A method and device for detecting sleep apnea is described. The method comprises: monitoring an instantaneous output power and an instantaneous rotation speed of a motor for delivering air in a breathing device; according to the instantaneous output power and the instantaneous rotation speed of the motor, obtaining an airway flow reference value represented for the air in an upper airway of a user using the breathing device; when it is determined that the user no spontaneous breathing according to the airway flow reference value, and corresponding duration has reached a preset time threshold value, determining the user to be in an apnea state; judging whether the upper airway of the user is clear; and determining the apnea of the user to be central apnea or obstructive apnea depending on whether the upper airway of the user is clear. The method and device can distinguish the type of sleep apnea.

Abstract: This pain measurement device (10) for measuring pain experienced by a subject (99) is provided with a determination unit (12) for determining a reference stimulation intensity corresponding to reference pain of the subject (99), on the basis of a relationship between pain levels reported by the subject (99) and stimulation intensities applied to the subject (99), and a measurement unit (13) which compares electroencephalographic data measured from the subject (99) and reference electroencephalographic data corresponding to the reference stimulation intensity to measure pain experienced by the subject (99) when the electroencephalographic data is measured.

Abstract: Embodiments classify a region of tissue demonstrating non-small cell lung cancer using quantified vessel tortuosity (QVT). One example apparatus includes annotation circuitry configured to segment a lung region from surrounding anatomy in the region of tissue represented in a radiological image and segment a nodule from the lung region by defining a nodule boundary; vascular segmentation circuitry configured to generate a three dimensional (3D) segmented vasculature by segmenting a vessel associated with the nodule, and to identify a center line of the 3D segmented vasculature; QVT feature extraction circuitry configured to extract a set of QVT features from the radiological image; and classification circuitry configured to compute a probability that the region of tissue will respond to immunotherapy and generate a classification that the region of tissue is a responder or a non-responder based, at least in part, on the probability.