Abstract: The shoe sole sanitizer provides a UV radiation emitting system that kills microbial pathogens deposited on shoe sole surfaces. The system includes a housing containing at least one UV radiation source. Bottom and side portions of the housing are opaque to provide a UV shield while directing the UV upward towards a top housing portion. The top housing portion has a plurality of holes forming an approximate shape of two shoe sole bottoms. The holes allow the UV radiation to escape the housing and target sole surfaces disposed on and over the exterior of the housing top. Each shoe sole approximation area has a pivotal tang that extends therefrom. Shutters attached internally to the tangs extend or limit UV exposure from the top surface depending on the size of the sole disposed on the top. The system is powered by standard AC electrical power or battery sources.

Abstract: A sterilization enclosure includes a main body defining a volume and having a movable component configured to move between an access position to allow access to the volume and a restricted position to at least partially enclose the volume. The sterilization enclosure further includes a light source located in the volume and configured to emit light having a frequency that injures pathogens. The sterilization enclosure further includes a switch coupled to the movable component and configured to be in a closed position to allow power to flow to the light source to cause the light source to emit the light into the volume when the movable component is in the closed position.

Abstract: Field balancing may be performed with an irradiation system including a plurality of adjustable radiant-energy emitters. The irradiation system powers the radiant-energy emitters from a power source and radiant energy is emitted from the radiant-energy emitters, where an amount of radiant energy emitted from each emitter is capable of being varied based on power received from the power source. A plurality of radiant-energy sensors detects an amount of radiant energy which includes radiant energy created directly by at least one of the radiant-energy emitters. The amount of radiant energy detected at at least two of the radiant-energy sensors is compared, and at least one of the radiant-energy emitters is adjusted by varying the power received from the power source so that the amount of radiant energy detected at each of the radiant-energy sensors tends towards becoming approximately equal.

Abstract: A lamp-based aroma diffuser using an aroma capsule is disclosed to include a lamp housing, a hollow light-transmissive shade mounted in the lamp housing, a holder member mounted in the lamp housing, a heat conduction device mounted in the holder member, a heating element kept in contact with the bottom wall of the heat conduction device, a light-emitting device, and a power supply device-incorporated PC board for driving the heating element to heat the heat conduction device and a replaceable aroma diffuser in the heat conduction device and the light-emitting device to emit color light through the hollow light-transmissive shade and the lamp housing.

Abstract: A multi-fragrance emission device includes an insert having a top portion, a bottom portion, and at least one side portion, the insert including a passageway extending between an entrance at the top portion and an exit at the side portion. A fan is configured to move air through the passageway, and an outer shell is sized to fit over at least a portion of the insert. The outer shell includes a plurality of scent chambers, each scent chamber being in communication with one of a plurality of scent release holes. A motor is coupled to the insert, the motor configured to move the insert to align the exit of the insert with one of the plurality of scent release holes.

Abstract: A preventative solution includes an aqueous base, 1 wt % to 6 wt % titanium dioxide having an average particle size of not greater than 100 nm, 0.5 wt % to 20 wt % alcohol having 2 to 4 carbons, and 3 wt % to 15 wt % of a binding agent. The preventative solution can be dispersed using a fogger, for example, sequentially with an odor neutralizing solution or a disinfectant solution.

Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium, magnesium, or strontium, a setting solution comprising H3PO4 and a buffer, and a biocompatible polymer that is incorporated into the setting solution. The powder is mixed with the setting solution to form a bone cement paste that either (a) sets into a hardened mass, or (b) is irradiated with electromagnetic radiation to form dry powders, the dry powders then being mixed with a second setting solution to form a radiation-assisted bone cement paste that sets into a hardened mass.

Abstract: There is provided a tissue adhesive to be applied to a tissue by mixing an adhesive component including an aqueous solution of a fish-derived gelatin with a curative component including an aqueous solution of a water-soluble crosslinking reagent, wherein the water-soluble crosslinking reagent has an amide linkage or an ethylene glycol unit or a sugar chain in the molecular main chain thereof and has two or more of an active ester group or an acid anhydride or an aldehyde group.

Abstract: A material or biomaterial comprising silicic acid condensates having a low degree of cross-linking, and methods for its production are subject-matter of the invention. A method for the production of silicic acid structures having a low degree of cross-linking is disclosed, wherein a sol is produced, wherein further condensation is prevented when specific cross-linking of the silicic acid is reached, wherein, preferably, structures having a size of 0.5-1000 nm are produced, e.g. polyhedral structures or aggregates of the same. Further condensation can be prevented by means of mixing with a polymer. In one embodiment, this comprises nano-structured, silicon dioxide (SiO2) having a low degree of cross-linking that is embedded in a polymer matrix. The material can be used in medicine for therapeutic purposes, and can enter into direct contact with biological tissue of the body in this connection.

Abstract: The present invention relates to a biological film-forming agent which is for facilitating wound healing and coating and protecting biological organs, and for coating and protecting damaged cells, wound surfaces, organs and damaged sites of organs, and wound surfaces reaching soft tissues such as muscle and facia, periosteum or bone cortex. Provided is a biological film-forming agent for suppressing exudation of intracellular fluid from damaged cells, suppressing expansion of inflammation reactions and secondary inflammation reactions resulting from production of fibrin and eliminating adverse effects caused by formation of stabilised fibrin on healing. Various problems can be solved by using the agent containing aluminium chloride, cyclodextrin and water as base components.

Abstract: A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.

Abstract: Intraocular lens materials are disclosed. They are soft and very deformable and have a high refractive index, and a high glistening resistance in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.

Abstract: A method for producing a bone regeneration material containing an octacalcium phosphate-gelatin complex, the method including: co-precipitating octacalcium phosphate with gelatin to produce an octacalcium phosphate-gelatin co-precipitate; washing the co-precipitate with a washing liquid to remove gelatin from the co-precipitate, thereby obtaining an octacalcium phosphate slurry; dispersing the octacalcium phosphate slurry or dry granules formed using the slurry in an aqueous gelatin solution; and drying the dispersion of octacalcium phosphate dispersed in the aqueous gelatin solution to produce an octacalcium phosphate-gelatin complex.

Abstract: A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.

Abstract: A composition and methods for improved delivery of a therapeutic agent to a stenosed vessel wall.

Abstract: An amorphous PDLLA stent coating for drug delivery is disclosed.

Abstract: Techniques, mixtures and improved porous materials (interconnected porous constructs) that are capable of maintaining a sufficient porosity while conferring improved mechanical and physical strength to the final construct. A sacrificial construct (for example, a sacrificial material such as polymethyl methacrylate (PMMA)) is used to obtain an inverse porosity of the construct it was molded into. The process provides a less porous end material that may be used as an arthroplasty device or surgical implant (for example, an interference screw of suture anchor) among many other applications. The process employs a sacrificial material to reduce the porosity of the final construct to about 35%.

Abstract: A system is illustratively described herein that generally comprises a vacuum chamber, an ambient pressure chamber, a valve configured for unidirectional flow from the vacuum chamber to the ambient pressure chamber during a charging stroke, and a liquid filter configured to retain liquid in the pump. In some embodiments, the liquid filter is configured to retain liquid in the vacuum chamber during the charging stroke. In other embodiments, it may be configured to retain liquid in the ambient pressure chamber during an operating stroke. In more particular embodiments, a piston may be disposed between the vacuum chamber and the ambient pressure chamber, a passage may fluidly couple the vacuum chamber and the ambient pressure chamber, and the valve can be configured to control fluid flow through the passage. Additionally, a lumen may couple the vacuum chamber to a dressing to deliver negative pressure to the dressing in some illustrative embodiments.

Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Abstract: Systems and methods for recharging zirconium phosphate and zirconium oxide in reusable sorbent modules are provided. The systems and methods provide for recharging any combination of zirconium phosphate and/or zirconium oxide sorbent modules. The systems and methods also provide for linkage of multiple rechargers for sharing of infrastructure.

Abstract: This disclosure relates to preventing over-delivery of a drug and related systems and methods. The method includes receiving, from a drug delivery device, information pertaining to a desired amount of fluid to be delivered by the drug delivery device and receiving information pertaining to a delivered amount of a fluid that has been delivered by the drug delivery device. The method also includes determining that the delivered amount satisfies a predetermined threshold amount and in response to the determination, detecting whether an initial amount of fluid provided to the drug delivery device corresponds to the desired amount of fluid to be delivered.

Abstract: Devices for the removal of cells or other particles from a biological fluid are disclosed. The devices include a removal medium housed within a chamber of a housing. The devices include inlet and outlet ports carried by the walls. One or both of the ports includes a flow path portion having a chamber-communicating portion that has a cross-section that is larger than the cross-section of an adjacent flow path portion.

Abstract: A blood processing filter for removing undesirable components from liquid containing a blood component or blood, comprises: a sheet-shaped filter element; and a hard container that includes an inlet-side container element and an outlet-side container element that are disposed to clamp the filter element, and has an internal space separated by the filter element into an inlet space and an outlet space, wherein the filter element includes a filtering surface on a side of the inlet space, a filtering surface on a side of the outlet space, and an end surface along peripheries of the pair of filtering surfaces, the inlet-side container element and the outlet-side container element are provided with a gripper that clamps and compresses an outer edge portion of the pair of filtering surfaces, and a thickness of the filter element is compressed at the gripper to be 0.05 to 0.5 times the thickness.

Abstract: Syringe assemblies comprising a first cap and a second cap to ensure sterilization of the fluid path without the need for external packaging are described. Also described are methods of sterilizing the fluid path of a syringe assembly.

Abstract: An IV line identification system to enable ready identification of an IV line and its associated fluid source and output and to enable distinguishing the IV line from other IV lines and their fluid sources and outputs. The IV line identification system includes a first light source and a second light source communicatively coupled to one another via a wireless connection. The light sources are configured such that when one is activated so as to generate a light signal, the other is automatically activated to generate a corresponding light signal. Each light source may be placed on opposite ends of an IV line to enable ready identification of each end of the same IV line.

Abstract: Disclosed is a disposable tubeless fluid delivery system, comprising a button unit for receiving instructions given by a user through pressing button, a key unit for outputting a selection instruction indicating at least one working mode a fluid reservoir unit for storing a fluid, an indwelling unit for letting through the fluid to a patient, wherein the indwelling unit comprises an indwelling cannula, and a fluid driving unit for delivering the fluid stored in the fluid reservoir unit to the subcutaneous tissue of the patient by the indwelling unit, and a control unit for outputting the delivery instruction to the fluid driving unit and controlling the fluid driving unit to deliver the fluid or suspend fluid delivery. In the present disclosure, a pump base and a wireless control device are integrated to achieve a purpose of small volume, low cost and convenient wearing.

Abstract: Some embodiments of a medical infusion pump system include a pump device having a flexible pushrod that can adjust from a curved configuration to a generally straight configuration. The flexible pushrod is part of a drive system of the pump device so that the flexible pushrod can be controllably and incrementally advanced toward a medicine reservoir to incrementally dispense the medicine therein. In particular embodiments, the flexible pushrod may comprise an anti-rotation mechanism, an anti-torsion mechanism, or a combination thereof.

Abstract: A system and method for automatically administering insulin based on a feedforward control. The automatic insulin delivery system may include a computing device comprising a processor, machine readable non-transitory media which stores the coupled-model of the invention, and a monitoring system. The machine readable transitory media may be configured to receive one or more inputs and the coupled-model may utilize a feedforward control to parameterize the inputs and generate an output that can be translated to a type and amount of insulin to be administered by the system. The input(s) received by the machine readable non-transitory media may be created by a user or received from one or more sensors. The method may include providing a model that is stored on a machine readable non-transitory media and administering insulin based on the output provided by the model.

Abstract: Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

Abstract: A drug delivery device for administering a drug is presented having a body, at least one electrical unit and a port for electrically contacting the electrical unit, an adapter for attaching an injection needle to the drug delivery device, a safety mechanism arranged to prevent contacting the electrical unit whilst an injection needle is in fluid communication with the drug delivery device and arranged to prevent establishing a fluid communication while the electrical unit is contactable.

Abstract: A conventional syringe defines a longitudinal axis and includes a syringe barrel having a syringe barrel flange laterally extending from an open proximal end of the syringe barrel and a plunger advanceable into the syringe barrel. A rotatable finger flange for such a syringe includes identical first and second flange components, each having an attachment member configured to releasably engage the syringe barrel flange and/or the other flange component, and a flange member laterally extending therefrom. The first and second flange component are engageable and rotatable relative to one another about the longitudinal axis between a non-use position, wherein the first flange member overlies the second flange member to reduce the finger flange footprint, and a use position, wherein the first flange member and the second flange member are angularly spaced apart from one another to provide a finger flange having a greater lateral extent than the syringe barrel flange.

Abstract: A syringe packaging system that includes a tube and a cap for enclosing a pre-filled syringe is disclosed. The tube includes a tube cut flange and the cap includes a cut skirt. With a syringe barrel contained within the tube, a syringe barrel cut flange is aligned with the tube cut flange. With the pre-filled syringe enclosed within the tube and the cap, the cut skirt of the cap surrounds the syringe barrel cut flange. In one embodiment, a film is securable to a portion of the tube and a portion of the cap to connect the tube and the cap with the pre-filled syringe enclosed within the cap and the tube.

Abstract: An automatic applicator for liquid pharmaceutical preparations, particularly for multiple injection application of set doses of a medicine from an exchangeable container is provided. The automatic applicator includes a body housing connected to a housing of an exchangeable container with a medicine having a plunger, the said plunger being displaced only linearly by an integrated driving unit, suitable for immobilizing, driving, leading linearly and blocking rotation of the plunger, driven via a double action clutch, by a tensioning spring situated in the body housing, the spring tensioned by a rotary hand-dose-setting ring via the double action clutch, wherein the driving unit is activated by a trigger unit and a dose is indicated by an indicating arrangement. The automatic applicator further includes at least one block key placed in an upper part of a ratchet barrel, collaborating with at least one key placed in an internal part of the body housing.

Abstract: An assembly for a drug delivery device is provided, the assembly including a blocking element and a piston rod having an interaction feature adapted and arranged to mechanically cooperate with the blocking element. For delivering a dose of a drug, the piston rod is configured to be moved from an initial position to an end position with respect to the blocking element, wherein the interaction feature is provided along the path between the initial position and the end position. An operating noise is provided to the user when the interaction feature mechanically cooperates with the blocking element while moving the piston rod for dose delivery. The interaction feature is adapted for homogenizing the operating noise so as to prevent the operating noise from being interpreted by the user as signalling the end of the dose delivery operation. Furthermore, a drug delivery device is provided.

Abstract: The invention relates to an apparatus, in particular for ejecting a fluid, having an electric motor (500), the motor comprising at least one motor winding (506a-d), having a control unit (656) for controlling the motor (500), wherein the apparatus further comprises an electronic detection circuitry (620) configured to determine an electrical quantity, the electrical quantity being a function of the electric resistance (Rw) of the motor winding (506a-d), and wherein the control unit (656) is configured to control the motor (500) as a function of the electrical quantity. The invention further relates to a method for controlling such an apparatus, comprising the steps of: determining an electrical quantity, the electrical quantity being a function of the electric resistance (Rw) of the motor winding (506a-d); and controlling the motor (500) as a function of the electrical quantity.

Abstract: The present application relates to a dispense interface comprising at least a first flat part tightly connected with a second flat part, wherein at least one of the at least two flat parts comprises at least one deepening configured for forming at least one part of a channel profile, wherein the at least one deepening is formed by embossing, wherein the channel profile comprises at least a first inlet channel and a second inlet channel and at least one outlet channel, wherein each of the at least two inlet channels is configured for fluid communication with a respective reservoir of at least two reservoirs.

Abstract: Syringe pump apparatus and methods for detecting proper or improper engagement of a syringe pump drive system with a syringe in the syringe pump are disclosed. The apparatus and methods can determine proper or improper engagement between a drive system and the plunger of a syringe in a syringe pump by detecting the force required to move a plunger clip in reverse while restricting flow into the syringe. The apparatus and methods may also be used to determine that a syringe in the syringe pump apparatus is properly connected to a delivery line.

Abstract: A medical or dental device for dispensing a powdered medium with a container having a container interior space. The container can be connected to a compressed gas source to convey the powdered medium together with the compressed gas out of the interior space, and to a dispensing unit, so that the powdered medium is conveyed with the compressed gas to the dispensing unit. The container comprises: a wall, and a bottom that is connected to the wall and has at least one bore through which compressed gas from the compressed gas source can be conducted into the interior space. A swirl plate made of a porous material is provided at the bottom. Compressed gas can be conducted through the porous swirl plate into the interior space to aerate at least a portion of the powdered medium without conveying the powdered medium out of the interior space to the dispensing unit.

Abstract: Vaporizing devices and related methods for controlling an amount of substance being vaporized for consumption by a user are disclosed herein. According to an aspect, a vaporizing device includes a casing configured to hold a substance for vaporizing. The vaporizing device also includes a plunger comprising a heating element inserted within the casing. The vaporizing device also includes a mechanism configured to advance the substance within the casing. Further, the vaporizing device includes a mouthpiece comprising an atomized configured to vaporize the material using the heating element.

Abstract: Dispenser for the discharge of pharmaceutical media having a liquid storage, a base body, an actuating handle that is manually displaced with respect to the base body for causing a discharge process of media from the liquid storage into an environment, and an electronic detection system for detecting discharge processes. A sensor is provided, which, subject to the displacement of a reference component mechanically coupled to the actuating handle such that during a discharge process the reference component is displaced with respect to the base body, generates an output signal. The sensor is configured for generating output signals of two distinguishable types as a function of the extent of the displacement, and is provided with an electronic calibration memory in which calibration data regarding discharge behavior of the dispenser are stored.

Abstract: In a method and breathing apparatus for providing support ventilation to a spontaneously breathing patient a pressure and/or a flow is monitored based on pressure and/or flow measurements, and efforts to inhale or exhale by the patient are detected based on changes in the monitored pressure and/or flow. When a change in the monitored pressure and/or flow indicating an effort to inhale or exhale is detected, the rate of that change is determined and used to calculate a suitable rate of change of pressure applied to the airways of the patient. By changing the applied pressure in accordance with the so determined suitable rate of change, the pressure rise time during inspiration and/or the pressure fall time during expiration can be adjusted to the needs of the patient to ensure efficient and comfortable ventilation.

Abstract: A device provides respiratory treatment such as for sleep disordered breathing and other respiratory conditions in a discreet configuration to provide a minimally invasive system. The system may include a flow pressurizer apparatus configured to generate a pressurized flow of air through a small bore delivery conduit toward a patient interface. The system may further include a treatment compensator coupled with the fine bore delivery conduit. The treatment compensator may be configured at the patient interface to reduce pressure for patient inspiration. A processor may control adjustments to the pressure generated by the flow pressurizer apparatus.

Abstract: A method for positioning a medical device in a respiratory system is provided. The method includes providing a medical device system including a positioning apparatus having a body section and an upper section, the upper section slidably coupled to the body section, a flexible guide rod, a visible light source, and a medical device for treating the patient slidably receivable on the flexible guide rod. The method also includes inserting the flexible guide rod into a treatment portion of a respiratory system, emitting visible light from the visible light source, visually observing, outside the patient's body, the emitted visible light, and slidably moving the medical device distally along the flexible guide rod toward the distal end of the flexible guide rod to a selected position relative to the distal end of the flexible guide rod and within said treatment portion of the respiratory system of the patient's body.

Abstract: Patient interface components and/or associated head gear and adjustment systems improve sealing and/or patient comfort and/or ease of use. The interface includes an inflating or ballooning seal. The headgear assembly can be connected to the interface with an elastic component and an inelastic component. The elastic component enabling a course fitting of the interface to the patient and the inelastic component enabling a final fitting of the interface to the patient.

Abstract: A gas supply mask apparatus allows a mask wearer to inhale a gas such as oxygen gas such that air in a mask main body does not much mix in the gas approaching substantially lower ends and the vicinities of the nostrils of the mask wearer in the mask main body. In this gas supply mask apparatus, a gas introduction opening for introducing a gas such as oxygen gas and water vapor into the mask main body includes a first gas introduction opening capable of introducing the gas in, e.g., a bundle-like state into the mask main body, and a second gas introduction opening capable of introducing the second gas into the mask main body so as to surround, in a substantially ring-like state, the above-mentioned, first gas in a bundle-like state introduced into the mask main body from the first gas introduction opening.

Abstract: A three-way air flow connector element is provided for operably introducing nebulized medication into an existing oxygen therapy line, which does not require the user to remove the oxygen line to administer the medication. The connector comprises a first and second female connector end and a third male connector end. The first female connector end is adapted to connect to an oxygen line while the third male connector end is adapted to connect to a patient mask, whereby oxygen can be delivered to the patient therethrough. The second female connector end is an operably opened conduit through which a nebulized medication can be introduced to the patient. This end is capped and removably opened by a medical professional, whereby the patient is not deprived of oxygen when connection is made with a nebulizer or similar oral medication delivery system.

Abstract: The present subject matter relates to systems and methods for selectively amplifying an acoustic signal in a closed environment. In an implementation, a plurality of acoustic signals may be received from within the closed environment. Frequency ranges corresponding to each acoustic signal may be obtained and compared to determine presence of at least one individual in the closed environment. Acoustic signals pertaining to the at least one individual may be analysed to detect occurrence of a physiological event. Based on the analysis, the acoustic signal may be recognized as a target signal, and the target signal may be amplified in the closed environment. Further, an interfering signal may be generated to cancel other acoustic signals within the closed environment.

Abstract: A packaged catheter includes a cover attachable to a container, an intermittent urinary catheter, and a urine collection bag. The container has a closed bottom and an opening formed in a proximal end of the container and communicating with a container cavity. The intermittent urinary catheter has a proximal portion insertable into a bladder and a handle portion connected to the proximal portion; and a urine collection bag connected to the handle portion of the intermittent urinary catheter. The handle portion of the intermittent urinary catheter is inserted into the opening formed in the proximal end of the container to provide a sealing structure between the handle portion and the opening in the container.

Abstract: Catheters, sheaths, or other tubular devices are provided that include a proximal end, a distal end sized for introduction into a patient's body, and a steerable distal portion. The tubular device includes a primary lumen extending between the proximal and distal ends; an auxiliary lumen adjacent the primary lumen; and one or more reinforcement members including windings extending helically along at least the distal portion, at least some of the windings passing between the primary and steering element lumens and at least some of the windings surrounding both the primary and steering element lumens. In one embodiment, a steering element is slidably disposed within the auxiliary lumen. Apparatus and methods for making such tubular devices are also provided.