Patents Issued in September 25, 2018
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Patent number: 10082477Abstract: The present invention is one that makes it possible to continuously measure the resistivity of a liquid sample with accuracy as well as preventing the deterioration of the liquid sample associated with measurement, such as change in quality, and relates to a resistivity-measuring circuit C that measures the resistivity in order to sense the deterioration of the liquid sample. The resistivity-measuring circuit C is one that calculates the resistivity of the liquid sample by detecting voltage generated between an outer electrode and an inner electrode, and between the outer electrode and the inner electrode, applies square wave AC voltage having an amplitude of 1 V to 42 V and a frequency of 0.5 Hz to 30 Hz.Type: GrantFiled: February 10, 2014Date of Patent: September 25, 2018Assignee: HORIBA ADVANCED TECHNO, CO., LTD.Inventors: Riichiro Suzuki, Tsunetoshi Sugawara, Tadashi Oshio
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Patent number: 10082478Abstract: A method to assess external corrosion in buried pipelines includes analysis of moisture content of soil along the length of the pipe to choose the most appropriate indirect inspection methods. External corrosion is assessed based on the unification of probability techniques using clustered inspection data and deterministic formulation for soil conditions. A deterministic model pinpoints the location of the most likely areas for corrosion due to the electrochemical cell formation produced by the presence of water and the properties of the soil, such as ion concentrations, pH, soil resistivity, redox potential, corrosion potential and soil type. The filtering of the data by clustering provides reliable results to locate the most corrosive locations. The failure probability is calculated based on in-line inspection data, where different indications could appear and different dimensions are used to link the corrosivity with the failure for choosing repairing methods and taking actions against corrosion.Type: GrantFiled: April 15, 2015Date of Patent: September 25, 2018Assignee: The University of AkronInventors: Homero Castaneda-Lopez, Ayako Yajima, Ximing Li, Qindan Huang
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Patent number: 10082479Abstract: A method for producing a pH half-cell by means of which, in combination with a reference electrode and an evaluation electronics unit, a pH value of a medium can be determined, comprises the following steps: applying a first structure and a second structure to a substrate, wherein the first structure is applied by means of a thin-film method and forms a resistance element having a temperature-dependent resistance value, and wherein the second structure can be employed to derive a pH-dependent potential; applying a structured passivation glass layer, wherein the passivation glass layer substantially covers the first structure and leaves the second structure substantially uncovered; applying a mixed-conducting glass, wherein the mixed-conducting glass is substantially applied to the region that was left uncovered by the passivation glass layer; and applying a pH-sensitive glass, wherein the pH-sensitive glass is applied to the mixed-conducting glass.Type: GrantFiled: March 30, 2015Date of Patent: September 25, 2018Assignee: INNOVATIVE SENSOR TECHNOLOGY IST IGInventor: Florian Krogmann
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Patent number: 10082480Abstract: A gas concentration detection device for detecting a gas concentration using a limiting current type gas concentration sensor. In an application voltage line set to pass through a plurality of limiting current regions for different values of gas concentration, a ratio for lean is set as a ratio of change in current with respect to a change in voltage when an air/fuel ratio corresponding to the gas concentration is lean, and a ratio of rich different from the ratio for lean is set when the air/fuel ratio is rich.Type: GrantFiled: May 17, 2017Date of Patent: September 25, 2018Assignee: NGK SPARK PLUG CO., LTD.Inventors: Satoru Abe, Tomonori Uemura, Tetsuya Ito, Satoshi Teramoto
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Patent number: 10082481Abstract: A pixel circuit acts as a sensing element in a sensing device. The pixel circuit includes a sensing electrode, a first gate electrically connected to the sensing electrode, a second gate in electrical communication with the first gate, and a readout device that is electrically connected to the second gate. An input voltage applied to the sensing electrode is amplified between the first gate and the second gate, the amplification being measured as an output signal from the readout device to perform a sensing operation. For example, the output signal may be relatable to pH, analyte measurements, or other properties of sample liquids analyzed by the sensing device. A sensing device may include multiple pixels disposed on a substrate, each pixel including said pixel circuit. Driver circuits controlled by control electronics are configured to generate signals that selectively address the pixels and to read out voltages at the sensing electrodes.Type: GrantFiled: July 7, 2016Date of Patent: September 25, 2018Assignee: Sharp Life Science (EU) LimitedInventors: Benjamin James Hadwen, Campbell Donald Brown, Christopher James Brown, Gregory Gay, SAlly Anderson
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Patent number: 10082482Abstract: A sensor element of an A/F sensor AS has a solid electrolyte layer, a first electrode arranged on one side of the solid electrolyte layer so as to be exposed to the exhaust gas of an internal combustion engine, and a second electrode arranged on the other side of the solid electrolyte layer so as to face an atmospheric air chamber. The sensor element generates a sensor output according to the oxygen concentration in the exhaust gas. A microcomputer supplies oxygen to the first electrode side from the second electrode side via the solid electrolyte layer by applying a predetermined voltage between the pair of electrodes of the sensor element. Moreover, the microcomputer determines a crack abnormality of the solid electrolyte layer based on electric current between the pair of electrodes which is generated with start of the oxygen supply.Type: GrantFiled: June 4, 2014Date of Patent: September 25, 2018Assignee: DENSO CORPORATIONInventors: Katsuhide Akimoto, Shuuichi Nakano, Yushi Fukuda, Tomofumi Fujii, Takahito Masuko, Toshihide Kumazaki
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Patent number: 10082483Abstract: A mechanism is provided for sensing molecules. A twin-nanopore probe includes a first channel and a second channel. A first pressure-controlled reservoir is connected to the first channel to generate a positive pressure. A second pressure-controlled reservoir is connected to the second channel to generate a negative pressure. A container includes ionic solvent with molecules, and a tip of the twin-nanopore probe is submerged in the container of the ionic fluid with the molecules. The first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with the ionic fluid. The first pressure-controlled reservoir drives the ionic fluid out of the first channel and the second pressure-controlled reservoir draws in the ionic fluid with the molecules and solvent through the second channel. A flow of ionic current in the twin-nanopore probe is measured to differentiate the molecules that flow through the second channel.Type: GrantFiled: February 19, 2015Date of Patent: September 25, 2018Assignee: GLOBALFOUNDRIES INC.Inventor: Hongbo Peng
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Patent number: 10082484Abstract: A chemically sensitive Hall device is described herein. In accordance with one example of the present invention, a Hall device comprises a substrate and a chemically sensitive layer arranged on the substrate. The chemically sensitive layer is able to interact with atoms or molecules of a gaseous or liquid fluid. Force electrodes are connected to the chemically sensitive layer for feeding a sensor current through the chemically sensitive layer along a first direction. Sense electrodes are connected to the chemically sensitive layer to tap a Hall voltage at the chemically sensitive layer along a second direction. A back gate is arranged on or integrated in the substrate and is isolated from the chemically sensitive layer by an isolation layer.Type: GrantFiled: August 25, 2016Date of Patent: September 25, 2018Assignee: Infineon Technologies AGInventors: Werner Breuer, Markus Eckinger
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Patent number: 10082485Abstract: In a method for leakage flux testing of ferromagnetic material to be tested, in particular ferromagnetic pipes, for detecting defects, a testing volume of the material to be tested is magnetized by a constant magnetic field. A surface of the material to be tested is scanned by a probe arrangement for capturing magnetic leakage fields caused by defects. The probe arrangement has a probe array with a multiplicity of magnetic-field-sensitive probes arranged next to one another in a first direction and held at a finite testing distance from the surface of the material to be tested during the testing. Electrical probe signals are evaluated for qualifying the defects. Use is made of a probe arrangement in which the probes each have a probe width in the first direction which lies in the range from 20% of the testing distance up to 10 mm.Type: GrantFiled: May 4, 2015Date of Patent: September 25, 2018Assignee: Institut Dr. Foerster GmbH & Co. KGInventors: Robert P. Uhlig, Friedrich Hecker
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Patent number: 10082486Abstract: A method for recognizing the presence of liquid (30) in a gas flow flowing in a pipeline uses an ultrasound flowmeter (10). Measurement paths are provided in pairs which are displaced vertically by an equal predefined distance with respect to the center axis such that one lies in an upper region above the center axis and one lies beneath the center axis. A check is made in three stages to define various measurement values, turbulence values and speed of sound values. A liquid warning signal is output when an invalid measurement value is delivered in the first stage, or when the ratio of the turbulence values in the second stage differs from 1 by more than a predefined tolerance value, or when the ratio of the speeds of sound in the third stage differs from 1 by more than a predefined tolerance ratio.Type: GrantFiled: April 6, 2016Date of Patent: September 25, 2018Assignee: SICK Engineering GmbHInventor: Andreas Ehrlich
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Patent number: 10082487Abstract: An apparatus and a method for ultrasonic detection are provided. The apparatus includes an injection nozzle which is installed below a steel plate being transported and forms a medium column by jet a medium toward the steel plate, an ultrasonic probe which is installed in the injection nozzle and transmits and receives ultrasonic waves for detecting flaws in the steel plate through the medium column, and a medium circulation unit which reclaims the medium which falls from the medium column and circulates the reclaimed medium to the injection nozzle.Type: GrantFiled: December 26, 2013Date of Patent: September 25, 2018Assignee: POSCOInventors: Choong Soo Lim, Myung Sik Chun, Hyeong Jun Huh, Boong Ho Son
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Patent number: 10082488Abstract: An ultrasound device, including a profile generator, an encoder configured to receive a profile signal from the profile generator, and an attenuator configured to receive a signal representing an output of an ultrasound sensor and coupled to the encoder to receive a control signal from the encoder, the attenuator including a plurality of attenuator stages, the attenuator configured to produce an output signal that is an attenuated version of the input signal.Type: GrantFiled: December 2, 2015Date of Patent: September 25, 2018Assignee: Butterfly Network, Inc.Inventors: Kailiang Chen, Tyler S. Ralston
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Patent number: 10082489Abstract: Valves, pumps, detectors, sample loops, fraction collectors and the like are individually incorporated into modules that are mountable in interchangeable manner at individual mounting sites on a base unit which also supports one or more chromatography columns. Each module includes fluid connections to other modules and a microcontroller joining the module to a computed and monitor through an electronic connector at each mounting site. The fluid connections between the modules and the column(s) are removed from the electronic connections and accessible to the user. A software platform recognizes the modules and their locations, coordinates fluid connections between the modules, and provides a variety of control, monitoring, data generating and data processing functions to generate chromatographic data.Type: GrantFiled: March 15, 2016Date of Patent: September 25, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Robert Iovanni, Alec Gordon, Bob Avarbock, Wayne Bland, Glenn Price, Ken Baker, Farah Mavandadi, Christof Schultz
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Patent number: 10082490Abstract: A variable data dependent acquisition/dynamic exclusion (vDDA/DE) method selects target m/z range utilizing a MS1 precursor topography map over the most recently acquired MS spectrum to identify the precursor m/z values and MS/MS acquisition parameters to improve the selection of the next data-dependent MS/MS acquisition. The topography used to define the next set of DDA scan events is defined by previous tandem MS scan events defined by precursor quadrupole isolation windows as well as all detected compounds contained within the specific tandem MS events. At least some of the parameters used for MS/MS data acquisition are dynamic so as to exhaustively sample the user specified MS mass range with MS/MS information. These parameters include the quadrupole MS isolation width and symmetry around the targeted m/z value. Using this approach, a greater proportion of the precursor m/z space is effectively and efficiently sampled per chromatographic peak width.Type: GrantFiled: February 19, 2018Date of Patent: September 25, 2018Assignee: Thermo Finnigan LLCInventors: Amol Prakash, Scott M. Peterman, David Sarracino
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Patent number: 10082491Abstract: A pearl grading method includes the following steps: (1) determining the color type of the pearl to be graded; (2) generating a simulated three-dimensional graph of the pearl to be graded; (3) calculating roundness, so as to obtain a roundness grade; (4) calculating the diameter of the simulated three-dimensional graph, so as to obtain a diameter grade; (5) drawing an illumination-wavelength reflection spectrum; (6) changing a detected part, and drawing an illumination-wavelength reflection spectrum again; (7) repeating the step (6) for at least two times; (8) performing weighted average to obtain a correction curve; and (9) comparing the correction curve with each glossiness grade spectrum baseline, so as to determine a glossiness grade according to the spectrum baseline with the highest coincidence degree. The method has the beneficial effects of low cost, high speed, good result consistency and high detection precision.Type: GrantFiled: July 14, 2015Date of Patent: September 25, 2018Assignee: ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Xi Feng, Yang Shi, Aihua Yu
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Patent number: 10082492Abstract: In one general aspect, an apparatus includes a probe including an exterior probe element including a first plurality of links defining a first flexible element. The exterior probe element defines a guard ring. The probe also includes an interior probe element including a second plurality of links defining a second flexible element and disposed within at least a portion of a perimeter defined by the exterior probe element. The apparatus includes a waveform generator electrically coupled to the exterior probe element and the interior probe element.Type: GrantFiled: June 14, 2016Date of Patent: September 25, 2018Assignee: Bringham Young UniversityInventors: Brian A. Mazzeo, William S. Guthrie, Jared Baxter, Jeffrey D. Barton
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Patent number: 10082493Abstract: The present disclosure provides methods of processing data provided by a transcutaneous or subcutaneous analyte sensor utilizing different algorithms to strike a balance between signal responsiveness accompanied by signal noise and the introduction of error associated with that noise. The methods utilize the strengths of a lag correction algorithm and a smoothing algorithm to optimize the quality and value of the resulting data (glucose concentrations and the rates of change in glucose concentrations) to a continuous glucose monitoring system. Also provided are systems and kits.Type: GrantFiled: April 29, 2016Date of Patent: September 25, 2018Assignee: ABBOTT DIABETES CARE INC.Inventors: Wesley Scott Harper, Erwin Satrya Budiman, Kenneth J. Doniger, Gary Alan Hayter
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Patent number: 10082495Abstract: The problem of confirming the presence of an adulterant in a urine sample is solved by the use of a reagent capable of reacting with uric acid and non-urate markers in a urine sample. In one embodiment, a phosphotungtate reagent is used to react with the urine sample to create a blue coloration in the presence of uric acid or uric acid equivalents. A reduction or elimination of the blue coloration, resulting in a reduction in the light absorbance, of the urine sample can be used as an indicator of the historical presence of an adulterant. An Oxidant History test can also be generated using the phosphostungtate reagent, wherein the light absorbance resulting from the blue coloration is measured over time, with a measured reduction in the absorbance being an indication that an adulterant is or has been present in the urine sample and is oxidizing the uric acid and non-urate markers over time.Type: GrantFiled: March 17, 2017Date of Patent: September 25, 2018Assignee: VISION DIAGNOSTICS, INC.Inventor: Jerry W. Denney
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Patent number: 10082496Abstract: The described invention provides methods for targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis.Type: GrantFiled: July 5, 2016Date of Patent: September 25, 2018Assignee: Board of Regents of the University of Texas SystemInventors: Jef De Brabander, Jerry W. Shay, Wentian Wang, Deepak Nijhawan, Pano Theodoropoulos
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Patent number: 10082497Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.Type: GrantFiled: March 27, 2015Date of Patent: September 25, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Peter Tseng, Ivan Pushkarsky
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Patent number: 10082498Abstract: The present invention relates to a method for optimizing drug therapy treatment of patients with Attention Deficit Hyperactivity Disorder (ADHD) or Bipolar Disorder (BD), a method of optimizing drug dosage for treatment of ADHD and BD, a method of treating ADHD and BD, and a kit. The present method may also be used to adjust medication doses for individual patients.Type: GrantFiled: May 15, 2014Date of Patent: September 25, 2018Assignee: PsychNostics, LLCInventors: Alagu P. Thiruvengadam, Douglas B. Woodruff
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Patent number: 10082499Abstract: The present invention relates to a method for preparation of labeled metabolic products, comprising the steps (a) providing a biological sample in vitro, (b) contacting the biological sample with a labeling buffer comprising a labeled substrate, wherein the substrate comprises at least one carbon atom and represents an educt or intermediate of a metabolic process of the biological sample and wherein the label is a stable isotope, (c) washing the biological sample using a wash-buffer, wherein said wash-buffer comprises a carbon resource such that the biological sample is precluded from carbon deficiency during said washing, wherein said carbon resource comprises the substrate according to step b), wherein said substrate in the wash-buffer may be labeled or unlabeled, (d) quenching the biological sample such that metabolic processes within the biological sample are slowed down or stopped and (e) extracting the labeled metabolic product from the biological sample.Type: GrantFiled: May 14, 2015Date of Patent: September 25, 2018Assignee: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZINInventors: Stefan Kempa, Matthias Pietzke, Christin Zasada
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Patent number: 10082500Abstract: One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a support structure, a hermetically-sealed, thermally decoupled central reaction zone associated with the support structure, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the support structure and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the support structure. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.Type: GrantFiled: February 19, 2015Date of Patent: September 25, 2018Inventors: Franz Baudenbacher, Raymond Mernaugh, John Mayo, Brad Lubbers, Robert G. Wiley
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Patent number: 10082501Abstract: Nanotube based lateral flow test device described herein is a lateral flow based diagnostic device, which uses arrays of fragments of single wall carbon nanotubes as sensor to detect the biomarkers at ultralow concentration (below picogram per milliliter). The device is consisted of the following components: (1). an lateral flow strip which typically is consisted of a backing film laminated with conjugate/sample pads, nitrocellulose membrane, wicking pad, (2). the arrays of single wall carbon nanotube conjugate with antibody which is immobilized on the membrane of the lateral flow device as the test line, (3). pairs of micro-electrode are installed on top part of the cassette, (4). a cassette which holds the lateral flow strip. The device can be used in clinical environments for biomarker detection.Type: GrantFiled: July 3, 2013Date of Patent: September 25, 2018Assignee: BioMedomics, Inc.Inventors: Xue-feng Wang, Qingqi Chen
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Patent number: 10082502Abstract: An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample.Type: GrantFiled: February 5, 2016Date of Patent: September 25, 2018Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.Inventors: James D. Kanaley, Zhong Ding, Philip C. Hosimer, Edward R. Scalice, Susan Danielson, David A. Tomasso, Timothy C. Warren
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Patent number: 10082503Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.Type: GrantFiled: March 13, 2014Date of Patent: September 25, 2018Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Irun R. Cohen, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
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Patent number: 10082504Abstract: The present disclosure provides an apparatus comprising an air circulating device, an allergen source comprising an allergen, and a housing. The housing can be collapsible, portable, disposable and configurable. The present disclosure also provides a method comprising positioning an allergen source comprising an allergen in a chamber, distributing at least a portion of the allergen from the allergen source within the chamber, and collecting at least a portion of the distributed allergen. In an embodiment, the level of the shed allergen can be used to measure the effectiveness of various measures implemented to reduce airborne Fel d1 that is emitted from soiled cat litter. In another embodiment, the allergen can be introduced at a desired level in the chamber, and the resultant symptoms of a subject (e.g. a human) within the chamber can be identified and correlated with the amount of allergen.Type: GrantFiled: November 17, 2015Date of Patent: September 25, 2018Assignee: Nestec S.A.Inventors: Richard Nelson, Ebenzer Satyaraj
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Patent number: 10082505Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.Type: GrantFiled: October 7, 2013Date of Patent: September 25, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland Stonesmith, Darren Barry Smith, Chao Sun
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Patent number: 10082506Abstract: The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including Streptococcus pneumonia, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumonia and Yersinia pestis. This interaction can be targeted to identify, purify and therapeutically target such organisms.Type: GrantFiled: November 5, 2015Date of Patent: September 25, 2018Assignee: Wisconsin Alumni Research FoundationInventors: Laura L. Kiessling, Darryl A. Wesener, Kittikhun Wangkanont
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Patent number: 10082507Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.Type: GrantFiled: September 30, 2013Date of Patent: September 25, 2018Assignee: President and Fellows of Harvard CollegeInventors: Samuel K. Sia, Vincent Linder, Babak Parviz, Adam Siegel, George M. Whitesides
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Patent number: 10082508Abstract: The disclosure provides methods for automated characterization of circulating tumor cells (CTCs), for example using automated tissue strainers. In specific examples, such methods permit characterizing a prostate cancer sample by simultaneously or contemporaneously detecting ERG rearrangements and PTEN deletions in the same CTC. Also provided are kits that can be used with such methods.Type: GrantFiled: March 2, 2016Date of Patent: September 25, 2018Assignee: Ventana Medical Systems, Inc.Inventors: Gary Pestano, Ryan Dittamore, Karl Garsha, Michael Otter, Chol Steven Yun, Alexandra Dea Nagy
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Patent number: 10082509Abstract: The invention relates to a method for labeling specifically living bacteria of a given category of Gram negative bacteria in a sample comprising bacteria, the method including the steps of: a) incubating the bacteria of the sample with at least one modified monosaccharide compound having a first reactive chemical group capable of reacting with a second reactive group, so that a monosaccharide residue bearing the first reactive group is incorporated into the polysaccharides of the outer membrane of such bacteria, and b) contacting the modified monosaccharide residue incorporated within the outer membrane of the bacteria, with a labeling molecule having a second reactive group.Type: GrantFiled: October 29, 2014Date of Patent: September 25, 2018Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLEInventors: Sam Dukan, Boris Vauzeilles, Aurelie Baron, Jordi Mas Pons
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Patent number: 10082510Abstract: Embodiments of the disclosure include methods and compositions for treatment of prostate cancer, including metastatic prostate cancer or prostate cancer at risk for developing into metastatic prostate cancer, by providing an effective therapy to an individual that has been determined to have elevated levels of SRC-2 (also known as NCOA2, GRIP1 TIF2). In particular cases, sample from an individual known to have prostate cancer is assayed for the risk for developing metastatic prostate cancer and the individual is provided an effective therapy upon determination of elevated levels of SRC-2.Type: GrantFiled: May 5, 2015Date of Patent: September 25, 2018Assignee: Baylor College of MedicineInventors: Bert W. O'Malley, Subhamoy Dasgupta, Nicholas Mitsiades, Arun Sreekumar, Sean E. Mcguire
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Patent number: 10082511Abstract: The present invention includes a method and apparatus for measuring the transport of analytes from living, biological cells through a cell barrier, which includes, but is not limited to, steps of providing the living, biological cells loaded with analytes, unloading at least a portion of said analytes from the cells through ion channels, removing unloaded analyte remaining in the cells, and measuring the analytes using x-ray fluorescence, specifically wherein the measurement uses an energy dispersive x-ray fluorescence spectrometer equipped with a microfocus x-ray tube. These steps may be repeated so that multiple measurements can be obtained over a period of time.Type: GrantFiled: October 26, 2016Date of Patent: September 25, 2018Assignee: ICAGEN, INC.Inventors: Benjamin P. Warner, Lori J. Peterson, Jennifer A. Berger, Eva R. Birnbaum, Rebecca L. E. Miller
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Patent number: 10082512Abstract: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.Type: GrantFiled: May 5, 2006Date of Patent: September 25, 2018Assignee: Drexel UniversityInventors: Timothy M. Block, Anand Mehta, Mary Ann Comunale
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Patent number: 10082514Abstract: Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.Type: GrantFiled: March 7, 2014Date of Patent: September 25, 2018Assignee: Lawrence Livermore National Security, LLCInventors: Carlos A. Valdez, Audrey M. Williams
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Patent number: 10082515Abstract: Method of incorporating a water soluble construct of the structure L-S-F into the lipid bi-layer of cells by contacting a suspension of the cells with a solution of the construct at a concentration and for a time and temperature sufficient to allow the construct to insert into the lipid bi-layer. In the structure L-S-F, F is a peptide, S is a spacer containing an oligomer of ethylene glycol covalently linking F to L and the number of ethylene oxide repeats in the oligomer of ethylene glycol is 6 to 14, and L is a phosphatidylethanolamine.Type: GrantFiled: February 12, 2013Date of Patent: September 25, 2018Assignee: KODE BIOTECH LIMITEDInventors: Cristina-Simona Weinberg, Nicolai Bovin, Stephen Micheal Henry
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Patent number: 10082516Abstract: A relative humidity control apparatus for control of the relative humidity in a gas space has a nebulizer source with an outlet for nebulized liquid, a frame surrounding an open area and comprising an opening arrangement to the open area and in operational flow connection with the outlet, and a flow drive arrangement generating a gas flow from the outlet to and out of the opening arrangement. A liquid handling robot comprising this apparatus, a method of operating the apparatus, an immunoassay method and methods of controlling the time course of the relative humidity in a gaseous space and of producing a predetermined volume of a liquid are also disclosed.Type: GrantFiled: July 14, 2016Date of Patent: September 25, 2018Assignee: TECAN SCHWEIZ AGInventors: Werner Looser, Erna Becker, Pius Fink, Marcel Aschwanden, Fredy Tanner
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Patent number: 10082517Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.Type: GrantFiled: March 30, 2016Date of Patent: September 25, 2018Inventors: Friedrich Ackermann, Andreas Calatzis, Rik Harbers, Roland Hutter, Jean-Pierre Bolliger, Theresa Kitcoff, Patrick Sascha Labud
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Patent number: 10082518Abstract: A sampling system is provided. The sampling system includes a housing. Mounted to the housing is a Hall effect sensor. A probe configured to contact a sample is inserted into the housing. The probe includes an elongated portion and a restorative spring inserted onto the elongated portion of the probe. The restorative spring provides sufficient restorative force to return the probe to a relaxed position. The Hall effect sensor is configured to sense a field strength generated by the proximity of the restorative spring of the probe in the extended position.Type: GrantFiled: November 17, 2016Date of Patent: September 25, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Glen Davis, John Jackson, Gregory Kaduchak, Wesley Smith, Michael Ward
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Patent number: 10082519Abstract: Disclosed are various embodiments for a berry impact recording device. The berry impact recording device comprises a shell. Within the shell are at least a sensor and an integrated circuit. The sensor may be configured to detect an acceleration of the berry impact recording device. The integrated circuit may be configured to record the acceleration of the berry impact recording device and a timestamp corresponding to the acceleration.Type: GrantFiled: November 6, 2017Date of Patent: September 25, 2018Assignee: University of Georgia Research Foundation, Inc.Inventors: Rui Xu, Changying Li
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Patent number: 10082520Abstract: Apparatus and associated methods relate to generating a frequency spectrum weighting function for use in estimating a rotational frequency of the rotating member. The estimation of the rotational frequency is based on vibrations sensed by an accelerometer remotely located from a rotating member. The frequency spectrum weighting function is generated by a supervised learning method. The method includes receiving a set of test vectors. The test vectors include a rotational frequency value of the rotating member and a vibrational frequency spectrum corresponding to vibrations propagated to the accelerometer. The vibrations include vibrations caused by the rotating member rotating at the rotational frequency. The method includes calculating a test weighting function, and then weighting the vibrational frequency spectra by the test weighting function.Type: GrantFiled: March 18, 2016Date of Patent: September 25, 2018Assignee: Simmonds Precision Products, Inc.Inventors: Lei Liu, Radoslaw Zakrzewski
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Patent number: 10082521Abstract: A system that measures six degrees-of-freedom of a remote target, the system including a dimensional measuring device having a camera, the remote target including a retroreflector, at least three light markers, and a pitch-yaw sensor, the six degrees-of-freedom determined based at least in part on measured 3D coordinates of the retroreflector by the dimensional measuring device, on a captured image of the at least three light markers by the camera, and on readings of the pitch-yaw sensor.Type: GrantFiled: December 29, 2016Date of Patent: September 25, 2018Assignee: FARO TECHNOLOGIES, INC.Inventors: Mikhail Atlas, Lawrence B. Brown, William W. Christine, Max K. Kim, Daniel J. O'Neill, James Schloss, Zhiguang Willam Xu, Robert E. Bridges
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Patent number: 10082522Abstract: Telematics system wherein a data processor is configured to: calculate a first rotation to isolate horizontal components of orientation data obtained from a three-axis accelerometer; calculate a second rotation of the orientation data dependent on acceleration data obtained from the velocity measuring device; and perform the first and second rotations on the orientation data to calibrate the orientation of the accelerometer relative to a vehicle on which the accelerometer is mounted. An associated method of calibrating the orientation of accelerometer is also provided.Type: GrantFiled: September 26, 2014Date of Patent: September 25, 2018Assignee: Quartix LimitedInventors: Thomas Dobra, Jeremy Bentham
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Patent number: 10082523Abstract: This invention involves measurement of optical properties of materials with sub-micron spatial resolution through infrared scattering scanning near field optical microscopy (s-SNOM). Specifically, the current invention provides substantial improvements over the prior art by achieving high signal to noise, high measurement speed and high accuracy of optical amplitude and phase. Additionally, it some embodiments, it eliminates the need for an in situ reference to calculate wavelength dependent spectra of optical phase, or absorption spectra. These goals are achieved via improved asymmetric interferometry where the near-field scattered light is interfered with a reference beam in an interferometer. The invention achieves dramatic improvements in background rejection by arranging a reference beam that is much more intense than the background scattered radiation.Type: GrantFiled: August 31, 2017Date of Patent: September 25, 2018Assignee: Bruker Nano, Inc.Inventors: Honghua Yang, Kevin Kjoller, Sam Berweger, Craig Prater
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Patent number: 10082524Abstract: A prober in which a probe head can be easily replaced is provided. A prober 10 includes a main body 12; a stage 11 provided within the main body 12 and configured to place a wafer W thereon; a card 16 provided within the main body 12 to face the stage 11; and a probe head holder 24 provided within the main body 12 and configured to be moved toward the card 16. The card 16 includes a probe head 30 which is detachably attached to the card 16 and has a multiple number of probe needles 35, and the probe head holder 24 is moved toward the card 16 while holding the probe head 30 thereon.Type: GrantFiled: June 6, 2014Date of Patent: September 25, 2018Assignee: TOKYO ELECTRON LIMITEDInventor: Mitsuyoshi Miyazono
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Patent number: 10082525Abstract: A probe unit according to the present invention is suitable for allowing a large current to flow. In the probe unit that accommodates a plurality of contact probes for electrically connecting an inspection target object and a signal processing device used to output an inspection signal, both ends of a large current probe (3) are electrically connected to electrodes of a contact target object, and a large current is made to flow via a metal block (50) that comes into contact with both end portions of the large current probe (3).Type: GrantFiled: September 18, 2015Date of Patent: September 25, 2018Assignee: NHK Spring Co., Ltd.Inventors: Yoshio Yamada, Kohei Hironaka
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Patent number: 10082526Abstract: An adjustable load transmitter for adjusting an alignment between a probe card and a bridge beam of a wafer prober, where the probe card is separated from the bridge beam by a gap. The adjustable load transmitter located in the gap, the adjustable load transmitter comprising two rotatable plates adapted for transmitting a load via a load transmission path between the bridge beam and the wafer prober and each comprising two flat, non-parallel contact faces. The adjustable load transmitter removes an angular misalignment between the bridge beam and the set of plates by rotating each of the rotatable plates about a pre-determined adjustment angle such that two angles of inclination are adjusted to zero. The adjustable load transmitter establishes the load transmission path by closing a clearance between the bridge beam and the contact face.Type: GrantFiled: December 29, 2017Date of Patent: September 25, 2018Assignee: International Business Machines CorporationInventors: Martin Eckert, Roland Dieterle, Siegfried Tomaschko
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Patent number: 10082527Abstract: A system for measuring current includes a conductive trace comprising N substantially parallel straight sections having a substantially constant cross-section, N?4. Adjacent substantially straight sections are spaced apart by a given distance and each pair of adjacent straight sections is connected by a respective loop of the current trace such that current in odd-numbered straight sections flows in a first direction and current in even-numbered straight sections flows in an opposite direction. The N magnetic field based current sensors are each positioned on a respective straight section of the conductive trace.Type: GrantFiled: November 13, 2015Date of Patent: September 25, 2018Assignee: TEXAS INSTRUMENTS INCORPORATEDInventors: Arup Polley, Russell Melvin Rosenquist, Terry Lee Sculley
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Patent number: 10082528Abstract: Some embodiments relate to power detector including a voltage sensor configured to detect a voltage of a load and a current sensor configured to detect a current of the load. The power detector also includes circuitry configured to introduce a phase delay between the detected voltage of the load and the detected current of the load, thereby producing a voltage measurement and a current measurement. The circuitry is also configured to multiply the voltage measurement and the current measurement.Type: GrantFiled: December 9, 2015Date of Patent: September 25, 2018Assignee: MediaTek Inc.Inventors: Meng-Hung Chen, Osama K. A. Shana'a, YuenHui Chee, Chiyuan Lu