Abstract: The invention relates to a method for discriminating cells of a cellular structure, notably of a cellular tissue, comprising the steps consisting in determining (12) a frequency spectrum of the impedance of the cellular structure; defining (22) at least one model of the impedance of the cellular structure including a constant phase element (30); determining (44) the impedance of the constant phase element (30) which optimizes the correlation of each model of the impedance of the cellular structure with the spectrum; and deducing (66), from the impedance of the constant phase element (30) or from the impedances of the constant phase elements (30), an item of information on the cells of the cellular structure. The invention also relates to a system for implementing the method for discriminating cells of a cellular structure.

Abstract: A system and method for imaging in connection with electrical currents includes nanoparticles introduced into a region in which the electrical currents are present. A low-field magnetic resonance imaging (MRI) scanner detects an effect of a magnetic field generated by interaction of the nanoparticles with the electrical currents in the region. The MRI scanner operates at a magnetic field intensity below a level at which the nanoparticles would be magnetically saturated.

Abstract: A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heartbeat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan. A first multiple of a duration between successive indicia of ventricular depolarization is selected, and a relaxation time T1 is determined based on the initial value Tinitial and the first multiple of duration. An optimized inversion time TIoptimal for LGE-MRI is determined based on the relaxation time T1 and a second multiple of a duration between successive indicia of ventricular depolarization. A correction factor is determined based on the optimized inversion time TIoptimal from the initial value of the inversion time TIinitial.

Abstract: The invention relates to an examination apparatus (100), a method and a computer program for tracking permanently magnetic beads (107) that are transported by a fluid flowing through a channel (106) of an object (105). The examination apparatus (100) comprises at least three magnetic field sensors (101, 102, 103) and an evaluation unit (104). With the magnetic field sensors, the magnetic field caused by the permanently magnetic beads (107) is detected. Due to shear forces acting in the fluid, the permanently magnetic beads (107) are rotating and the magnetic field caused by the beads (107) is temporally varying. This temporal variation of the magnetic field is used by the evaluation unit (104) for discriminating sub-signals related to single beads (107) from the overall signal generated by the magnetic field sensors. Furthermore, the evaluation unit determines positioning information of individual beads on the basis of the discriminated sub-signals.

Abstract: An apparatus, system and method determining a position of an instrument (100) are provided. A sheath (104) is configured to fit within an instrument channel of a medical scope. An optical fiber (112) is disposed within the sheath and a plurality of sensors (106) is integrated in optical fiber. The sensors are configured to measure deflections and bending in the optical fiber. A fixing mechanism (140) is sized to fit within the instrument channel in a first state and fixes the sheath within the instrument channel in a second state such that the fixing mechanism anchors the sheath and the optical fiber so that the deflections and bending in the optical fiber are employed with a pre-procedural volumetric image to determine a position of the instrument.

Abstract: Holographic image-guidance can be used to track an interventional device during an endovascular percutaneous procedure. The holographic image guidance can be provided by a head-mounted device by transforming tracking data and vasculature image data to a common coordinate system and creating a holographic display relative to a patient's vasculature to track the interventional device during the endovascular percutaneous procedure. The holographic display can also include graphics to provide guidance for the physical interventional device as it travels through the patient's anatomy (e.g., the vasculature).

Abstract: A predictive disease breath database system (PDBDS) may accumulate information about the volatile, semi-volatile, and non-volatile organic compounds in breath/saliva. Such information may be analyzed over time to identify disease indications as early as possible, using non-invasive data collection via breath and alert patients directly for follow-up with a health professional.

Abstract: Orthopedic systems and methods are provided for use in preparing joints for implants. Specifically, hip preparation systems and methods are disclosed which can include a surgical orientation device. The hip preparation systems and methods can be used, for example, to orient the hip during the procedure, determine the orientation of an anatomical plane or planes, and orient a prosthetic component or components.

Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.

Abstract: A variety of techniques are used automate the collection and classification of workout data gathered by a wearable physiological monitor. The classification process is staged in order to correctly and efficiently characterize a workout type. Initially, a generalized workout event is detected using motion and heart rate data. Then a location of the monitor on a user is determined. An artificial intelligence engine can then be conditionally applied (if a workout is occurring and a suitable device location is detected) to identify the type of workout. In addition to improved speed and accuracy, a workout detection process implemented in this manner can be realized with a sufficiently small computational footprint for deployment on a wearable physiological monitor.

Abstract: An apparatus for producing information indicative of cardiac condition includes a processing system for receiving a rotation signal indicative of rotational movement of a chest. The processing system is configured to form one or more indicator quantities each being derivable from an energy spectral density based on one or more samples of the rotation signal, where each sample has a temporal length. The processing system is configured to determine an indicator of cardiac condition on the basis of the one or more indicator quantities. The determination of the cardiac condition is based on that for example myocardial infarction causes changes in the energy spectral density. Thus, it is possible to distinguish between for example myocardial infarction and plain heartburn.

Abstract: This invention comprises wearable deformable electromagnetic energy pathways which enable ambulatory (camera-free) three-dimensional human body motion capture including trans joint pitch, yaw, and roll. It can be embodied in a plurality of elongate electrically-conductive strips which diverge as they span a body joint in a proximal to distal manner and pairs of electromagnetic energy emitters and receivers which are in electromagnetic communication with the strips. In an example, conductive-fluid-filled lumens can be used instead of electrically-conductive strips.

Abstract: Mouth guards and related systems and methods for determining linear and angular accelerations of the head of a subject. A plurality of accelerometers are operatively associated with the mouth guard and spaced from one another about the mouth guard. The accelerometers produce outputs indicative of the linear and angular acceleration of the mouth guard. Optionally, the mouth guard can be used in conjunction with a helmet that is provided with a plurality of accelerometers spaced about the helmet. In use, the outputs of the accelerometers of the helmet can be correlated to the outputs of the accelerometers of the mouth guard.

Abstract: A disposable lancet assembly includes: a spring aligned along a linear axis; a lancet aligned along the linear axis adjacent to the spring; a needle cup aligned along the linear axis adjacent to the lancet; and a housing including a channel that accepts an actuator interface such that the needle cup and lancet are able to be moved along the linear axis via the actuator interface. A medical test cartridge includes: a bottom plate; a microfluidic chip; and a top plate, wherein the top plate is coupled to the bottom plate such that the microfluidic chip is retained between the top plate and the bottom plate. A sample collection and testing device includes: a lancet assembly; a lancet actuator coupled to the lancet assembly; and a microfluidic test chip.

Abstract: Some embodiments relate to a reconfigurable biosensor adapted for performing tests in a plurality of modes or a smartphone or wearable device comprising the reconfigurable biosensor.

Abstract: A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.

Abstract: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

Abstract: Methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, storing the determined analyte concentration and a time associated with the determined analyte concentration, retrieving two or more stored analyte concentrations, and determining an adjusted dose level based at least in part on a current dose level and data associated with the two or more retrieved analyte concentrations are provided. For example, adjustments to dosage levels of long-acting insulin may be provided to assist in the management of diabetes and related conditions.

Abstract: An optical fluid measurement element includes: an emitter that generates an optical output; an absorber that measures an optical input; and a fluid flow pathway, where the optical output of the emitter passes through the fluid flow pathway and is received as the optical input to the absorber after passing through the portion of the fluid flow pathway. An automated method of measuring fluid volume using an optical fluid measurement element includes: activating an emitter; capturing data from an optical sensor; detecting a leading edge of fluid travelling along a flow pathway; starting a counter when the leading edge is detected; and calculating a volume based on a value of the counter. An automated method of measuring fluid attributes along a flow pathway. The method includes: activating an optical emitter; receiving a signal from an optical sensor; and processing the received signal to determine at least one fluid attribute.

Abstract: A tissue oximetry system employing diffuse optical spectroscopy includes an optical subsystem and an electronics and processing subsystem, together generating modulated optical signals processing a response optical signal in order to obtain measurements of blood oxygen values for a tissue from per-wavelength absorption values. Signal sources generate RF modulation signals, and ADC circuitry generates streams of digital sample values from analog detection signals.

Abstract: Systems and methods for measuring oxygenation signals are presented. The method includes positioning an oxygenation measuring system over a side portion of a head of a user, wherein the oxygenation measuring system includes an outer shell, a gel seal coupled to the outer shell, a near-infrared spectroscopy sensor configured to measure oxygenation signals from a user, a printed circuit board coupled to the near-infrared spectroscopy sensor, and a bone conducting transducer. The method further includes measuring the oxygenation signals from the user using the near-infrared spectroscopy sensor, recording data pertaining to the measured oxygenation signals of the user, and comparing the data, using the printed circuit board, with known human performance data.

Abstract: The invention relates to a blood treatment device with an extracorporeal blood circulation, which uses a gas sensor to measure the concentration of a gas in the gas supernatant of the drip chamber of the extracorporeal blood circulation. The blood treatment device has an evaluation unit, which calculates the corresponding partial pressure of the gas in the blood from the values measured in the gas supernatant in the drip chamber.

Abstract: The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

Abstract: The invention is directed to methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments.

Abstract: A method and a system for generating stress level information indicative of a stress level of a plurality of individuals. The method and system comprises receiving, via a network, individual stress information for each of the plurality of individuals, and generating, in a processing system, a statistical value for the stress level of the plurality of individuals by statistically processing the individual stress information for each of the plurality of individuals.

Abstract: Techniques are described for image analysis and representation for emotional metric threshold generation. A client device is used to collect image data of a user interacting with a media presentation, where the image data includes facial images of the user. One or more processors are used to analyze the image data to extract emotional content of the facial images. One or more emotional intensity metrics are determined based on the emotional content. The one or more emotional intensity metrics are stored into a digital storage component. The one or more emotional intensity metrics, obtained from the digital storage component, are coalesced into a summary emotional intensity metric. The summary emotional intensity metric is represented.

Abstract: Disclosed herein is a sensor attached to viscera to measure a change in length, in which the sensor includes a first layer having a first surface attached to the viscera and a second surface opposite to the first surface, a second layer having a third surface attached to the second surface and a fourth surface opposite to the third surface and expanded or contracted as the viscera is expanded or contracted, and a third layer having a fifth surface attached to the fourth surface and a sixth surface opposite to the fifth surface and attached to a catheter, and the first layer to the third layer are a film including silk fibroin and a calcium compound.

Abstract: Systems and methods for optimizing body and object interactions are provided. Based on obtained contact pressure maps and coefficient of friction (COF) maps at a contact interface where at least a portion of a body is in physical contact with a surface of an object, friction force maps can be determined, which can be used to optimize body and object interactions.

Abstract: A automated stroke detection and treatment support system can include: a brain scan analyzer for determining a stroke diagnosis in response to a brain scan of a patient, the stroke diagnosis including an indication of whether or not the brain scan indicates a possible stroke and a set of parameters pertaining to the possible stroke; and a treatment planner for generating a treatment report for aiding a physician treating the patient in response to the stroke diagnosis.

Abstract: The present invention discloses an allergy detection chip, a preparation method thereof, and a method for detecting allergy therewith. The allergy detection chip comprises a substrate; a plurality of nanoprojections, disposed on a surface of the substrate; a plurality of gold nanoparticles, disposed on the surface of the substrate comprising the nanoprojections; a plurality of linkers, attached to the surface of each of the gold nanoparticles at one end respectively; and a plurality of antibodies, having a carboxyl end of a heavy chain covalently bonded to the other end of each of the linkers respectively. By means of the allergy detection chip disclosed in the present invention, whether a patient has high risk of allergy can be quickly detected, so as to reduce the risks faced by the patients and the healthcare personnel.

Abstract: A method of determination of a cause of hemorrhoids in a subject includes a determination of the presence of hemorrhoids in the subject by visual inspection, and by one or more of a non-invasive medical imaging procedure and/or an intra-vascular visualization procedure, determining if there is an obstruction or occlusion in an iliac vein of the subject, and if so, determining that the hemorrhoids were caused by such obstruction or occlusion. If the obstruction or occlusion are determined to be the cause of the hemorrhoids, a procedure for compressing the obstruction or occlusion in the iliac vein of the subject, such as by angioplasty or stenting, is performed. After an appropriate time period, changes to the hemorrhoids in the subject are determined by a subsequent visual inspection.

Abstract: The invention relates to an apparatus and method to determine and monitor the flow rates and volume of fluids excreted or secreted by the body. The apparatus includes: a measuring unit comprising a conduit made of a material having a low thermal conductivity and supporting at least two thermistors that includes an upstream thermistor serving as a compensation thermistor and a downstream thermistor located as far downstream as possible from the upstream thermistor and pre-heated to and kept at pre-defined temperature which is warmer than the fluid temperature to be metered. The apparatus further includes a power supply for applying small electric voltages to the thermistors to enable generation of an electric signal; and a control and display unit being operatively connected to the measuring unit.

Abstract: Methods, systems and devices for evaluating the integrity of a uterine cavity. A method comprises introducing transcervically a probe into a patient's uterine cavity, providing a flow of a fluid (e.g., CO2) through the probe into the uterine cavity and monitoring the rate of the flow to characterize the uterine cavity as perforated or non-perforated based on a change in the flow rate.

Abstract: The various embodiments herein relate to systems, devices, and methods for tracking abdominal orientation and activity for purposes of preventing or treating conditions of pregnancy or other types of medical conditions. In certain specific embodiments, the system, device, or method relates to identifying abdominal orientation risk values, calculating and updating a cumulative risk value, comparing the cumulative risk value to a threshold, and outputting a warning when the cumulative risk value crosses the threshold.

Abstract: Systems for characterizing skin type including an illumination source configured to generate and direct light of one or more wavelengths onto a skin area; an optical sensor configured to receive the light reflected from the skin area illuminated by the illumination source and generate a corresponding electronic signal; a memory containing computer-readable instructions for: processing the electronic signal to identify one or more properties of the reflected light received by the optical sensor for use in characterizing one or more skin types within the skin area, and automatically characterizing the one or more skin types within the skin area based at least in part on the one or more identified properties of the reflected light; and a processor configured to read the computer-readable instructions from the memory and automatically characterize the one or more skin types within the skin area. Corresponding methods are disclosed.

Abstract: Provided herein are systems, methods and devices for the Detection and Prevention of Pressure Ulcers. The system, methods, and devices generally relate to sensors and fluid systems for detecting ulcers and preventing further pain for the patient and allow healthcare providers with valuable information to reposition a patient.

Abstract: In some embodiments, there is provide a method of analysing a bone fracture, comprising; stabilizing a bone having a fracture including a first support point located distal of the fracture and a second support point located proximal of the fracture; applying a force to an area of the bone having the fracture to cause a displacement of the fracture; imaging the bone during the application of force thereto; and comparing the image of the bone during the application of force to an image of the bone without the application of force to determine the state of the fracture.

Abstract: Provided is an apparatus for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphological index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. An osteoporosis diagnostic support apparatus, wherein the apparatus has a contour extraction unit adapted to extract a mandibular contour from an image of a mandibular cortical bone photographed by a photographic apparatus adapted to photograph the mandibular cortical bone and surroundings thereof, a line segment extraction unit adapted to extract line segments from the image of the mandibular cortical bone photographed by the photographic apparatus; and a cortical bone thickness calculation unit adapted to calculate a thickness of the cortical bone based on the extracted mandibular contour and line segments.

Abstract: This brain activity feedback system includes a brain activity measurement device to optically measure brain activity; a data processor to calculate, on the basis of measurement data from the brain activity measurement device, a statistic that indicates the statistical significance of changes in the measurement data; and a display device to display, in real time, a brain activity index corresponding to the statistic. The data processor calculates the statistic for the measurement data from the brain activity measurement device by correcting the scalp blood flow component of the measurement data in real time on the basis of scalp blood flow data.

Abstract: The disclosed physiological feedback systems and methods assist with assessing, monitoring and/or treating a patient experiencing a cardiac arrest event. The systems and methods receive multiple inputs and are continuous and/or iterative during a treatment session to provide physiological state trends of the patient. An index of the physiological state of the patient can be derived and confounders, and/or their effects, can be identified, and/or removed, from the index. Additionally, the systems and methods can assist with determining ischemic injury in a patient based on cerebral tissue oxygenation and/or other physiological data.

Abstract: Systems, methods, and devices that provide personalized sleep improvement programs for improving sleep habits are described. The personalized sleep improvement programs may include sleep characteristics of a user, at least one factor impacting a sleep of the user, at least one sleep goal for the user, and a sleep-related performance of the user.

Abstract: A system and method for monitoring disease, such as lung disease via a communication device of a user is disclosed. The system and method may include a communication device, such as a smartphone, a laptop, a smartwatch and the like, and may including a memory and a processor configured to: obtain information related to a user's medical condition; determine, while the user is using the communication device, respiratory characteristics of the user based on a recording of a respiration of the user; and determine a progress of a disease of the user based on the user's medical condition and based on comparing the characteristics to a reference set of characteristics. The reference set of characteristics may be created, by the processor, by obtaining signals related to the user's breathing while the user uses the communication device.

Abstract: Systems, devices, and methods for performing precise treatment, mapping, and/or testing of tissues are disclosed. Systems, devices, and methods for administering an agent to one or more a precise regions within a tissue mass are disclosed. Systems, devices, and methods for treating targeted regions within a tissue mass are disclosed. Systems, devices, and methods for identifying, localizing, monitoring neural traffic in the vicinity of, quantifying neural traffic in the vicinity of, and mapping neural traffic near targeted regions within a tissue mass are disclosed.

Abstract: The invention provides a wearable apparatus and an audio-video recording method thereof. The wearable apparatus includes a sensing module, an audio-video (AV) module and a control module. The sensing module senses a physiological information of a user and an environment information of an environment where the user is located. The AV module captures a video and an audio around the user as an AV signal. The control module compares the physiological information and the environment information with at least one reference information. When at least one of the physiological information and the environment information matches one of the at least one reference information, the control module determines that an event occurs, and preserves and stores the AV signal within a period of time before and after a time point at which the event occurs.

Abstract: A wrist-worn type electronic device includes a wrist-type electronic device includes a device body, an outer frame, a physiological information induction module and a control unit. The device body includes a front surface and a back surface which are opposite each other. The outer frame surrounds the front surface. The physiological information induction module includes a pair of electrocardiogram electrodes which are arranged opposite on the device body, and one of the electrocardiogram electrodes is disposed on the outer frame. The control unit is electrically connected these electrocardiographic electrodes.

Abstract: The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health.

Abstract: Disclosed are appendage mountable electronic systems and related methods for covering and conforming to an appendage surface. A flexible or stretchable substrate has an inner surface for receiving an appendage, including an appendage having a curved surface, and an opposed outer surface that is accessible to external surfaces. A stretchable or flexible electronic device is supported by the substrate inner and/or outer surface, depending on the application of interest. The electronic device in combination with the substrate provides a net bending stiffness to facilitate conformal contact between the inner surface and a surface of the appendage provided within the enclosure. In an aspect, the system is capable of surface flipping without adversely impacting electronic device functionality, such as electronic devices comprising arrays of sensors, actuators, or both sensors and actuators.

Abstract: A wearable vital sign monitor. The wearable vital sign monitor includes a band, where the band secures the wearable vital sign monitor relative to a user. The band includes an interior surface, the interior surface being the surface closest to the skin of the user and an exterior surface, the exterior surface opposite the interior surface. The wearable vital sign monitor also includes a first sensor array. The first sensor array is attached to the band and includes at least two sensors. The wearable vital sign monitor further includes a second sensor array. The second sensor array is attached to the band a fixed distance from the first sensor array and includes at least two sensors. The wearable vital sign monitor additionally includes an electronics module. The electronics module is configured to receive a first signal from the first sensor array, receive a second signal from the second sensor array, and transmit the sensor data to an external device.

Abstract: Systems and methods for applying and/or receiving electrical, magnetic, magnetoelectric, vibratory, or electromagnetic signals to biological tissues are described. In some embodiments, one or more of a body, a conductor, and an electrode may be provided. In some embodiments, a filament may be used as an electrode and may be placed in contact with a biological tissue portion. In some embodiments, a signal may be applied and/or received via the filament or other electrode.

Abstract: Systems and methods for applying and/or receiving electrical, magnetic, magnetoelectric, vibratory, or electromagnetic signals to biological tissues are described. In some embodiments, one or more of a conductive tip and a base may be provided. The tip may include a channel and an outer surface that approximates a portion of a sphere or cone and may be sized to fit within a user's ear. The base may be configured to be coupled to the tip and may include a conductor in electrical contact with the tip such that an electrical signal may pass between the base and the tip.