Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.

Abstract: An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that are analyzed to differentiate between and identify tags that are attached to, or associated with, the sample. Tag differentiation may be spectral and/or temporal based. Identification of the tags may be used to detect, analyze, and/or sequence the biomolecule.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

Abstract: The invention relates to a device for analyzing biological objects comprising a Raman spectroscopy system for capturing at least one Raman spectrum. The device comprises an arresting apparatus, which is designed to at least temporarily arrest the biological objects. An electronic computing apparatus is designed to determine a reaction of a biological object arrested by the arresting apparatus to at least one substance in accordance with an evaluation of the at least one Raman spectrum.

Abstract: In multicolor Coherent anti-Stokes Raman Scattering, a fingerprint region is a region densely filled with signals, and information about an intensity or spatial distribution of the signals is important for cell analysis. However, when laser power was increased due to the low signal intensity, there was a problem that cells were damaged. Thus, the present invention was configured such that the number of pulses of laser light emitted from a short pulse laser light source was changed by a pulse modulator. Accordingly, damage to the cells can be suppressed without significant reduction in signal intensity.

Abstract: A method of detecting single molecule includes: providing a carrier, wherein the carrier includes a substrate, and a plurality of three-dimensional nanostructures are located on the substrate; disposing single molecule samples on the plurality of three-dimensional nanostructures; detecting the single molecule samples with a detector; wherein each three-dimensional nanostructure includes a first rectangular structure, a second rectangular structure, and a triangular prism structure; the first rectangular structure, the second rectangular structure, and the triangular prism structure are stacked in that order, a first width of a bottom surface of the triangular prism structure is equal to a second width of a first top surface of the second rectangular structure and greater than a third width of a second top surface of the first rectangular structure, and the first rectangular structure comprises a first metal and the triangular prism structure comprises a second metal.

Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.

Abstract: A compact, low cost device for laser induced breakdown spectroscopy (LIBS) makes use of a silicon photomultiplier detector and a photon counting method.

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively.

Abstract: Various techniques are disclosed to provide a cloud-based, networked infrared (IR) inspection routing system that provides a user interface for remotely defining an inspection routing workflow for an inspection of a site, and provides an IR camera that presents customized and context-aware instructions to an on-site inspector to perform the inspection. The IR camera may be further configured to analyze IR images that are captured during the inspection and provides additional guidance in response to the analysis of the captured IR images according to the defined inspection routing workflow.

Abstract: An image inspection apparatus includes an illuminating section for irradiating illumination light, a line camera in which a plurality of imaging elements are arrayed to be linearly arranged, the line camera receiving the light irradiated from the illuminating section and reflected on the inspection target object, a display section for displaying an image captured by the line camera, an optical axis adjusting section for adjusting an optical axis of the line camera, a trigger setting section for specifying a trigger that specifies timing when the inspection target object is imaged by the line camera, an aspect ratio adjusting section for adjusting longitudinal and lateral pixel resolutions of the image captured by the line camera, and a display control section for displaying the optical axis adjusting section, the trigger setting section, and the aspect ratio adjusting section on the display section in order.

Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

Abstract: To make it possible to set a shift direction of phases of illuminance distributions of pattern lights to an appropriate direction and perform an inspection at high accuracy while improving setting flexibility of an illuminating section and an imaging section. A phase shift direction of pattern light irradiated from a pattern light illuminating section is determined according to moving direction information concerning a moving direction of an inspection target object with respect to an array direction of light receiving elements and positional relation information concerning a positional relation between the light receiving elements and the pattern light illuminating section.

Abstract: Defects from a hot scan can be saved, such as on persistent storage, random access memory, or a split database. The persistent storage can be patch-based virtual inspector virtual analyzer (VIVA) or local storage. Repeater defect detection jobs can determined and the wafer can be inspected based on the repeater defect detection jobs. Repeater defects can be analyzed and corresponding defect records to the repeater defects can be read from the persistent storage. These results may be returned to the high level defect detection controller.

Abstract: There is provided an X-ray Talbot capturing apparatus that emits X-rays in a cone beam shape from an X-ray generator, capable of producing gratings as easily as possible and of minimizing a production cost. An X-ray Talbot capturing apparatus 1 includes a G1 grating that is a phase grating, a G2 grating that is an absorption grating, a X-ray generator 11 that emits the X-rays, and an X-ray detector that includes a plurality of two-dimensionally arrayed conversion elements and captures a moire image Mo formed on the G2 grating. The G2 grating is located at a position where a self-image of the G1 grating 14 is formed, and both of the G1 grating and the G2 grating are in a plane shape. Slits of the G1 grating are formed to be perpendicular to a surface direction of a substrate on which the grating is formed, whereas slits of the G2 grating are formed to be parallel with the X-rays emitted in the cone beam shape from a focus F of the X-ray generator.

Abstract: A method and a system for resolving a crystal structure of a crystal at atomic resolution by collecting X-ray diffraction images. The method includes the steps: a) ejecting a droplet of fluid comprising single or multiple of crystal into an ultrasonic acoustic levitator; b) levitating the droplet of fluid with the crystal in the ultrasonic acoustic levitator; b) monitoring the position and the spinning of the droplet with a visualization apparatus; c) applying X-ray to the crystal, the X-ray stemming from an X-ray source; and d) detecting the X-ray diffraction images from the crystal irradiated by the X-ray source by an X-ray detector being capable to capture two dimensional diffraction patterns.

Abstract: A method of quantitative X-ray analysis includes capturing X-ray fluorescence data from a pressed powder sample including a binder. A quantity and/or distribution of binder is assumed and the concentration of various components of the sample is calculated from the measured data and the assumed quantity of binder. Then, the concentration of binder is adjusted and the calculation step repeated until the method converges. The method is allowed to take widely different values of quantity of binder, which may be the concentration of the binder in the sample or alternatively the thickness of an assumed thin layer at the surface of a model used for calculation.

Abstract: An apparatus for X-ray measurement, includes an X-ray source, an X-ray detector, an optical inclinometer, and a processor. The X-ray source is configured to generate and direct an X-ray beam to be incident at a grazing angle on a surface of a sample. The X-ray detector is configured to measure X-ray fluorescence emitted from the surface of the sample in response to being excited by the X-ray beam. The optical inclinometer is configured to measure an inclination of the surface of the sample. The processor is configured to calibrate the grazing angle of the X-ray beam based on the measured inclination, and to further fine-tune the grazing angle based on the X-ray fluorescence measured by the X-ray detector.

Abstract: An exhaust gas sensing system includes a channel for flow of exhaust gas, a first directional antenna, a second directional antenna, a first transmitter, a first receiver, and signal processing circuitry. The first directional antenna and the second directional antenna are disposed in the channel. The first transmitter is coupled to the first directional antenna. The first receiver is coupled to the second directional antenna. The signal processing circuitry is coupled to the first transmitter and the first receiver.

Abstract: In order to make it possible to remove dust produced in a heating furnace 10 more efficiently than ever before, the present invention is adapted to include: a dust discharge passage L that communicates with the inside of the heating furnace 10 and is for discharging dust produced by heating a sample X; a dust accommodating part 30 that accommodates the dust discharged from the dust discharge passage L; and a negative pressure generating mechanism 90 that is provided in the dust discharge passage L and generates negative pressure in the dust discharge passage, in which the negative pressure generated by the negative pressure generating mechanism 90 guides the dust from the heating furnace 10 to the dust discharge passage L.

Abstract: At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.

Abstract: A gas detection apparatus for detecting the concentration of a first gas component contained in a gas under measurement includes a gas conversion section for convening the first gas component to a second gas component, a gas detection section whose electrical characteristics change with a change in the concentration of the second gas component when the gas detection section is in an activated state, and a detection state setting section. During a detection period, the detection state setting section sets the state of gas detection by the gas detection section to a detection executed state in which the gas detection section can detect the second gas component. During periods which are not the detection period, the detection state setting section sets the state of gas detection by the gas detection section to a detection suspended state in which the gas detection section does not detect the second gas component.

Abstract: Methods and systems for monitoring fluid levels and electrolyte levels used in a dialysis machine. A receptacle, configured to receive a container, comprises a plurality of curved side panels and a base to form a cylindrical shaped cavity for receiving a container. Each panel includes a conductive material on its inner surface and, optionally, a shielding on its outer surface. An electronics component housed within, or near, the receptacle drives the capacitive process and interprets generated data to determine fluid levels and compositions. An alternate receptacle includes one or two coils wrapped about the container and uses induction to determine fluid level.

Abstract: A humidity meter includes a humidity sensor, a heating device oriented towards the humidity sensor, a signal generator capable of modulating a power output of the heating device, and a lock-in amplifier capable of demodulating a response signal of the humidity sensor as induced by the modulated heating device. A method of measuring humidity includes the steps of providing a humidity sensor positioned along a channel, a heating device positioned opposite the humidity sensor along the channel, and a controller including a signal generator and a lock-in amplifier; providing an airflow along the channel; modulating a power supply to the heating device using the signal generator; and demodulating a response signal of the humidity sensor induced by the modulated heating device.

Abstract: A system and method for imaging, monitoring, or measuring systems and processes utilizing only data provided from capacitance sensors. The present invention combines the multi-frequency method of both ECVT/AECVT and DCPT to image or measure processes and systems more efficiently and accurately than the methods alone. The present system analyzes capacitance and current phase acquired at multiple frequencies to determine a plurality of properties of single and multiphase systems all at once. The combined use of ECVT and DCPT in multiphase flow can also be extended to measure volume fraction and phase distribution of flows involving greater than three phases by using multiple frequencies for capacitance, current phase, or both.

Abstract: A biosensor including a capillary chamber having an inner boundary, a working electrode including an effective working electrode portion positioned within the capillary chamber, and a counter electrode including an effective counter electrode portion positioned within the capillary chamber, and with the working and counter electrodes each having a neck that constitutes the sole portion of the electrodes that extends across the inner boundary and out of the capillary chamber. In one embodiment, the effective working electrode portion defines an average working electrode width, and the working electrode neck defines a working electrode neck width that is reduced relative to the average working electrode width.

Abstract: A blood glucose monitor includes a can, a replaceable sensor cartridge that includes a frame, an upper spring disposed between the frame and the can, a case for housing the can and sealing the frame, a lower spring disposed between the can and the case, and a meter housing for sealing an upper portion of the frame. The can is capable of accepting the replaceable sensor cartridge. The frame of the removable cartridge has at least at least two walls defining a chamber for accepting a plurality of biosensors, and a bottom portion defining an opening and at least one sealing flange. The frame can further include a desiccant material capable of reducing humidity within the frame. The frame may be dimensioned such that an interference fit constrains the plurality of biosensors prior to inserting the frame within a blood glucose monitor.

Abstract: A potential measurement device according to the present disclosure includes a plurality of read-out electrodes arranged in an array shape and configured to detect a potential at a potential generation point generated due to a chemical change, and a reference electrode configured to detect a reference potential. The reference electrode is arranged within the array of the read-out electrodes. With this configuration, a low-noise potential measurement device in which noise superimposed on a wire from each of the read-out electrodes to an amplifier and noise superimposed on a wire from the reference electrode to the amplifier, i.e., wiring noise, can be reduced is achieved.

Abstract: Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof.

Abstract: The present disclosure provides devices, systems and methods for automated processing of biological samples. This disclosure provides a gel-frame cassette for an automated bioprocessing device, comprising: a gel-frame comprising: a front face, a back face, a frame comprising: two vertical side bars, each comprising a gel-frame holding hole, a top bar connecting the two vertical side bars, a bottom bar connecting the two vertical side bars and a hollow chamber enclosed by the two vertical side bars, the top bar, and the bottom bar; a front panel in contact with the front face of the gel-frame, the front panel comprising an expanded upper portion, and a back panel in contact with the back face of the gel-frame, the back panel comprising a horizontal opening at the bottom of the back panel. This disclosure also provides an automated bioprocessing machine that processes the gel-frame cassette or the gel-frame.

Abstract: Devices and systems and methods for concentrating and electrochemically detecting an analyte in an aqueous sample are provided. These devices, systems, and methods are useful for detecting an analyte, which as naturally found or produced, occurs at a concentration below that which can be measured using conventional methods.

Abstract: An inspection apparatus comprises a light output unit configured to output first light having a first wavelength and second light having a second wavelength, a magneto-optical crystal arranged so that a reflection film faces a measurement target, a light detection unit configured to detect the first light and the second light, and a light guide optical system configured to guide the first light and the second light toward the magneto-optical crystal and the measurement target, and guide the first light reflected by the magneto-optical crystal and the second light reflected by the measurement target toward the light detection unit. The light guide optical system comprises an optical path switching element configured to perform switching between optical paths of a plurality of optical elements so that the first light and the second light are selectively incident on the light detection unit.

Abstract: There are provided a sensor element and a sensor device having high measurement accuracy by improving temperature characteristics. A sensor element includes an element substrate, a detection portion located on an upper surface of the element substrate, and a protective film covering at least a first IDT electrode and a second IDT electrode. The element substrate is formed of quartz and has the following Euler angles, ?=0°, 97.2°???128.9°, and 85°???95°. An expression 0<tc?0.17? is satisfied, in which tc denotes a thickness of a part of the protective film covering the first IDT electrode and the second IDT electrode, namely denotes a thickness standardized by a wavelength ? (?m) of a surface acoustic wave.

Abstract: A fluid sensor including a sensing area configured to receive a fluid. The fluid sensor includes a transducer and a capacitive sensor. The transducer is configured to output an ultrasonic wave through the fluid. The capacitive sensor includes a capacitive plate configured to reflect the ultrasonic wave toward the transducer.

Abstract: This method for determining a mechanical property of a layered soft material, includes steps of a) generating an ultrasound wave (W1) focused towards a first point (P1) of the material, said wave, upon interacting with a layer of said material, generating in turn a Lamb (L1) wave propagating into said layer of the material, b) measuring, at a second point (P2) of the material belonging to said layer, a physical parameter of the generated Lamb wave, c) automatically determining the mechanical property of the layered soft material, based on the measured physical parameter. Step a) is performed by exciting a first ultrasonic transducer (401) with a first excitation signal (S401) during at most 50 ms, step b) is performed by exciting a second ultrasonic transducer (402) with a second excitation signal (S402) during at most 0.

Abstract: A system for assessment of irregularity in wooden material below the surface of a substrate, from above the surface of the substrate. The wooden material extending from below to above the surface of the substrate and surrounded by the substrate below the surface of the substrate. The system comprising at least one transmitter and receiver or transducer arranged to transmit energy through the material from above the surface of the substrate towards the part of the material below the surface, and to receive energy reflected from the material back through the surface, and a processor arranged to analyse the reflected energy and provide an indication of irregularity in the material below the surface of the substrate.

Abstract: Disclosed is a system and method of determining the test surface profile and compensating the gain amplitude when using time reversal focal laws in ultrasound non-destructive testing. Computer simulations are used to compute the diffraction field at time of incidence of the transmitted parallel wave front on the test surface. Knowledge of the surface profile and the diffraction field allows determination of coverage at the test surface and improved accuracy of flaw sizing.

Abstract: Methods and systems disclosed herein use acoustic energy to determine a gap between a wafer and an integrated circuit (IC) processing system and/or determine a thickness of a material layer of the wafer during IC processing implemented by the IC processing system. An exemplary method includes emitting acoustic energy through a substrate and a material layer disposed thereover. The substrate is positioned within an IC processing system. The method further includes receiving reflected acoustic energy from a surface of the substrate and a surface of the material layer disposed thereover and converting the reflected acoustic energy into electrical signals. The electrical signals indicate a thickness of the material layer.

Abstract: A system for analyzing fiber reinforced composite including: an ultrasonic transmitter configured to provide ultra-sonic pulses to the fiber reinforced composite; an ultrasonic receiver configured to receive ultrasonic signal data related to the ultrasonic pulses; a filter module configured to filter the ultrasonic signal data; a signal processing module configured to process the filtered ultrasonic signal data; an analysis module configured to analyze the processed ultrasonic signal data by: calculating a characteristic value based on the ultrasonic signal data; comparing the characteristic value to a baseline established for the characteristic value; and determining a percentage of design strength based on the comparison; and an output module configured to output the percentage of design strength.

Abstract: A system for performing gas chromatography analyses in accordance with the present disclosure includes an analytical column and a column oven. The analytical column has an inlet portion coupled to an injector for receiving a material sample and an outlet portion coupled to a detector. The analytical column is adapted to direct the material sample from the injector to the detector. The column oven is adapted to heat the analytical column for separating constituent components of the material sample for detection by the detector.

Abstract: The invention relates to monolithic sorbents which are clad with tubes made of metal. The metal cladding can be applied directly to the monolithic sorbents by cold forming. This enables very mechanically stable cladding of the monolithic sorbents with minimal dead space.

Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.

Abstract: Provided herein are kits, compositions and methods for biomarker detection, and the use of relative or absolute levels of these markers for non-invasive detection of stress and/or relaxation levels in human subjects. In particular, the present invention relates to cortisol, isomer and metabolite markers for stress and/or relaxation levels.

Abstract: Disclosed herein are compounds and methods for identifying and quantifying a metabolite or breakdown product of PEG. A sample may be assayed for PEG metabolites or breakdown products using liquid chromatography combined with mass spectrometry. Derivatization of the PEG metabolites or breakdown products within the sample with pentaflurobenzoyl chloride in conjunction with negative chemical ionization mode liquid chromatography optimizes the assay.

Abstract: A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate. A droplet dispenser can dispense drops of a sample or a sample-containing solvent into the open end of the housing. A sensor and a processor can be provided to monitor and maintain a liquid dome present at the open end.

Abstract: A new electrospray emitter capable of cone-jet mode spray for liquid flow-rates from sub-microliter/minute to 10's of microliters/minute is provided. The high efficiency of ionization and vaporization enabled by the disclosed spray emitter provides improved sensitivity for mass spectrometer detection. The disclosed spray emitter sprays consistently and robustly a liquid buffer having a large range of compositions of aqueous and organic solvents, and is not sensitive to the polarity of the electric field used to induce spray. The fluidic channel leading to the spray emitter opening does not have an internal taper rendering the spray emitter clog-resistant.

Abstract: A quantitative analysis assistant program that creates a quantitative table showing the relationship of compounds, quantitative values and other related information for each of two data files A and B, and displays on each of the view areas “a” and “b”. The analysis operator specifies one compound in one of the quantitative tables. Then, the other quantitative table is automatically searched for a compound having a name identical to the specified compound. A chromatogram, mass spectrum and other related information corresponding to that compound and are based on data file B are displayed on the view area “b” along with the quantitative table. Then, measurement results corresponding to the compound based on data file A are displayed on view area “a” along with the quantitative table. A comparison of the measurement or quantitative determination results for the same component can be easily and efficiently performed in a simultaneous multicomponent analysis.

Abstract: Method and corresponding detection unit to detect bacterial activity in a biological sample, in particular, but not only, blood samples contained in a test tube with a stopper.