Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.

Abstract: The invention provides methods, kits and reagents for diagnosing fibromyalgia (FM) in an individual by determining whether the levels of one or more cytokines in the individual are altered, as compared to control levels. The altered level(s) or patterns of expression of the cytokines measured in the affected individual compared to the level from the control is predictive/indicative of FM in the individual.

Abstract: Provided is a composition including a combination of at least one short peptide and at least one peptide dimer, in defined ratio, to which autoantibodies found in elevated levels in schizophrenic patients bind.

Abstract: The present invention relates to a method for determining the extracellular volume status of a subject. The method comprises determining in a sample obtained from a subject the level of the marker proadrenomedullin (proADM) or a fragment thereof, preferably MR-proADM. Further, based on the level of proADM or a fragment thereof, the fluid balance is determined and wherein said fluid balance determines the extracellular volume status. Further, based on the level of proADM or a fragment thereof, the salt balance is determined and wherein said salt balance determines the extracellular volume status and salt retention. Further, the invention relates to a method for in vitro diagnosis, risk stratification, therapy control and/or operative control of a disorder or medical condition in a subject, wherein said extracellular volume status and salt retention of said subject is determined by the herein provided method.

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

Abstract: Disclosed is a method for measuring a clotting time, including the steps of: (A) mixing a blood sample, an activator, a phospholipid, and a nickel ion-forming compound to obtain a specimen; and (B) mixing the specimen obtained in step (A) with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen.

Abstract: A method for diagnosis of HIT (Heparin-induced thrombocytopenia) in a patient's serum or plasma sample and a system comprising kits for performing the method are provided, where the method involves incubating a patient's sample with and without heparin and normal control sample with and without heparin with a platelet-rich plasma (PRP) of an individual not having a platelet disorder and then incubating an aliquot of each sample with a first label for both heparin activated and non-heparin activated platelets and a second label for platelets activated by the heparin-immune complex formed in the patient sample. HIT is diagnosed when the difference between the amount of activated platelets from the patient's sample with and without heparin is substantially larger than the difference between the normal control sample with and without heparin.

Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject, wherein the biomarker is compound 509.

Abstract: The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic ? cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic ? cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic ? cells.

Abstract: A specimen analyzer includes: an analysis unit which analyzes a specimen collected from a subject and generates an analysis result including a component amount in the specimen; an output unit which outputs the analysis result; and a controller which causes the output unit to output or not to output the component amount based on a comparison between the component amount and a determination reference value.

Abstract: The specimen analyzer includes: an input unit which receives an input of subject attribute information; an analysis unit which performs measurement of a specimen collected from a subject, and which performs analysis of the specimen based on a measurement result and the subject attribute information received by the input unit; and a controller which causes the analysis unit to be incapable of analyzing the specimen unless the input of the subject attribute information is performed with the input unit.

Abstract: This specimen analyzer includes: an analysis unit which analyzes a specimen collected from a subject; a manual input unit which receives an input of information by manual operation; an information read unit which receives an input of information by reading an information record section provided in a consumable; and a controller which does not permit an input of information on the consumable with the manual input unit, and permits an input of the information on the consumable with the information read unit.

Abstract: A method of operating a laboratory sample distribution system is presented. The system comprises sample container carriers comprising a magnetically active device and configured to carry a sample container, interconnected transport plane modules configured to support carriers, and electro-magnetic actuators arranged in rows and columns below each transport plane module and configured to move a carrier on top of the transport plane modules by applying a magnetic force to the carrier. The method comprises assigning transport plane modules to a route category. At least two traffic lanes are formed on the route categorized transport plane module. The carriers are moved within each traffic lane in a transport direction. The transport directions are opposite to each other. The method also comprises assigning another transport plane module to a waypoint category. A change from one transport direction to the opposite transport direction is possible on the waypoint categorized transport plane module.

Abstract: A transport device unit for a transport device assembled using a plurality of transport device units is presented. The transport device unit comprises a base plate module with a base plate for fixing the transport device unit to a support frame, an actuator module with a plurality of electro-magnetic actuators, where the actuator module is supported by the base plate module, and a driving surface module with a driving surface element, where the driving surface element is arranged above the actuator module covering the actuators and configured to carry sample container carriers. A transport device, a system for at least partially disassembling the transport device, and a laboratory sample distribution system comprising a transport device are also presented. In addition, a laboratory automation system comprising a laboratory sample distribution system is also presented.

Abstract: An automatic analyzer includes a specimen holding section that holds a specimen container for containing a specimen; a specimen dispensing section that dispenses the specimen from the specimen container into a dilution container; a dilution container holding section that holds the dilution container for containing a diluted specimen, which is the specimen that has been diluted; a diluted specimen dispensing section that dispenses the diluted specimen from the dilution container into a reaction container; and a controlling section that, while the diluted specimen dispensing section dispenses the diluted specimen into the reaction container in accordance with a measurement item, causes the specimen dispensing section to perform a cleaning operation of the specimen dispensing section any number of times by using a cleaning liquid.

Abstract: The objective of this disclosure is to provide a dispensing apparatus that is capable of precisely dispense micro volume liquid samples without physically damaging the nozzle tip or the liquid containers. An example of the present disclosure images a droplet of a liquid sample, and dispenses the liquid sample using an image of the droplet.

Abstract: Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.

Abstract: The image capturing part 201 captures a ball in flight with a camera continuously. The image corresponding part 203 generates a first registered ball image obtained by making a size of a first ball image in a first capturing image captured first correspond to a size of a second ball image in a second capturing image captured second. The 3D model constructing part 204 constructs a 3D model of the first registered ball image obtained by converting a camera coordinate system of the generated first registered ball image into a world coordinate system. The virtual rotating part 205 rotates virtually the constructed 3D model of the first registered ball image by using a rotation parameter estimated in advance and rotation matrix information.

Abstract: A neural network including a set of input nodes may consume a respective stream of time-series data recorded during a flight of a flying aircraft, each stream of time-series data representing measurements of a respective flight parameter captured by a sensor at various time-steps of the flight. A training circuit set may train the neural network to predict a future measurement of the flight parameter. Training the neural network may include comparing a predictive value from the neural network to a measured value of a flight parameter and modifying structural components of the neural network to bring the predictive value closer to the measured value. A parameter acquisition circuit set may acquire time-series data of a flight parameter. A prediction circuit set may apply the time-series data to the trained neural network to predict the next measurement for the flight parameter in the time-series data.

Abstract: A 6-degree of freedom (DOF) PZT actuator-based dither stage includes a 6-DOF PZT Z-cut bimorph actuator-based stage. A net motion sensor includes a 6-DOF PZT Z-cut bimorph actuator-based stage and a PZT Z-cut bimorph actuator-based sensing cantilever coupled to the stage to detect motion. Methods to detect inertial sensor fixed offset, bias, and net motion are disclosed.

Abstract: There is provided an information processing apparatus to provide a mechanism capable of improving accuracy of detection of abnormality of sensors without changing configurations of the sensors, the information processing apparatus including: an acquisition unit configured to obtain a first value obtained by measurement in a first measurement unit and a second value obtained by measurement in a second measurement unit whose dynamic range regarding measurement is a second dynamic range different from a first dynamic range of the first measurement unit; and a detection unit configured to detect abnormality of the first value or the second value on a basis of a change in a correlation between the first value and the second value.

Abstract: An additional test operating mode for an acceleration detector including two acceleration sensors in a differentiated operating mode. For this purpose, an additional test operating mode is provided, in which the reference voltage for one acceleration sensor is inverted. By comparing the output signals of the acceleration sensors and during the test operating mode, an interference, in particular a contamination of the sensors or influences by parasitic capacitances in the sensor system may be detected.

Abstract: Disclosed herein are devices, systems and methods for in-line, nanoscale metrology. One system comprises monolithic flexure mechanisms with integrated actuators that allow movement and positioning in two axes, with an extremely high degree of accuracy, of a structure comprising one or more scanning probes. This structure is suspended to prevent any destructive interference from a sample, which can be stationary or moving at a nonzero rate, and rigid or flexible in mechanical behavior. This system can be activated at startup and quickly actuate the structure to approach the surface of the sample. Once the system achieves the desired proximity between the one or more probes and the sample, the system maintains that position of the structure to a high degree of accuracy regardless of any disturbances. This array can be moved at varying speeds laterally to match the velocity of any continually moving substrates, thus enabling scanning of moving substrates.

Abstract: The present disclosure relates to probe sheaths adapted for a probe housing positioned within a turbomachine fluid flow path. A probe sheath according to the disclosure can include: a non-metallic sheathing material having at least one opening shaped to enclose a first portion of a fluid probe therein, the non-metallic sheathing material being sized for placement within an interior cavity of the probe housing; and a metallic sheathing material mechanically coupled to a first end of the non-metallic sheathing material and sized for placement within the interior cavity of the probe housing. The metallic sheathing material may include at least one opening in fluid communication with the at least one opening of the non-metallic sheathing material, and may be shaped to enclose a second portion of the fluid probe therein.

Abstract: The present invention relates to a contact and a socket device for testing a semiconductor device. The contact of the present invention is a spring contact which is integrally formed by blanking and bending a metal plate member and includes an elastic portion made of various strips of certain pattern and a tip provided at both ends of the elastic portion. Preferably, an inner volume of the contact is filled with a filler having conductivity and elasticity, whereby durability and electrical characteristics are excellent. Further, the test socket according to the present invention is a rubber type employing the above-mentioned contact and has an advantage that it is suitable for testing a fine pitch device.

Abstract: A contact head (6) for an electrical test device (1) for electrically testing substrates, which have electrical contact points, with at least two guide plates (13, 14) that are arranged to each other by a spacer (15) and each have guide openings (16) essentially aligned with each other for receiving pin-shaped contact elements (8) and are oriented to each other by a centering device (20), wherein the centering device (20) has four centering pins (19), which are displaceably mounted in a slot (23), extending toward a center (Z) of the contact head (6), at least of one of the guide plates (13, 14), and wherein the centering pins (19) are each held in a centering opening (18) of the spacer (15). It is provided that the centering openings (18) each have only one guide surface (21) oriented at least essentially parallel to a radial axis (R)—in relation to the center (Z).

Abstract: The present disclosure discloses a conductivity sensor including a basic body of sintered ceramic having at least two cavities disposed on a frontal face and a metal electrodes disposed in each cavity. Each electrode is about one fifth the length of the basic body. Electrical cables extend from a rear face of the basic body into holes in each cavity and contact the electrodes. A solder paste or an electrically conductive adhesive disposed in each hole connects each cable with the respective metal electrode electrically and mechanically.

Abstract: A method of forming surface protrusions on an article, and the article with the protrusions attached. The article may be an Integrated Circuit (IC) chip, a test probe for the IC chip or any suitable substrate or nanostructure. The surface protrusions are electroplated to a template or mold wafer, transferred to the article and easily separated from the template wafer. Thus, the attached protrusions may be, e.g., micro-bumps or micro pillars on an IC chip or substrate, test probes on a probe head, or one or more cantilevered membranes in a micro-machine or micro-sensor or other micro-electro-mechanical systems (MEMS) formed without undercutting the MEMS structure.

Abstract: A wired rubber contact including a lower film, an upper film, a plurality of conductive wires, a rubber layer, and a film guide. The lower film includes a plurality of lower electrode parts formed in openings. A periphery of the upper film is disposed within an interface between the central area and the peripheral area. The conductive wires are disposed between the lower film and the upper film, and connect between the lower electrode parts and the upper electrode parts. The rubber layer includes elastic material. A periphery of the rubber layer is protruded toward an outer side from the periphery of the upper film. The rubber layer maintains a constant distance between the lower film and the upper film. The film guide is disposed in the peripheral area of the lower film along a side surface of the rubber layer and integrally formed with the lower film.

Abstract: An electric current sensor of electric equipment includes a detection element, a reference voltage line to which a reference voltage signal is transmitted, an output signal line to which an output signal of the detection element is transmitted, and a ground line connected to a ground potential. The reference voltage line, the output signal line, and the ground line are bundled together by a cylindrical member which does not contain metal, and in this state, the reference voltage line, the output signal line, and the ground line are routed inside a casing containing a reactor, and connected to a control device.

Abstract: In an electric power device and a method of producing the electric power device, in an axial direction of a reactor, a distance between a detection element of a second electric current sensor and a central position of a winding part is shorter than a distance between a detection element of a first electric current sensor and a central position of a winding part. Further, a gap length of a core of the second electric current sensor is smaller than a gap length of a core of the first electric current sensor.

Abstract: A system includes an electrically conductive handle, a detector, and a controller. The electrically conductive handle is configured to move along a fixed handle path relative to a floor. The detector is electrically coupled to the handle and is configured to detect at least one of a voltage or an electrical charge at the handle during movement of the handle relative to the floor along the handle path. The controller is configured to initiate an event based upon the voltage or charge detected at the handle during movement of the handle relative to the floor along the handle path.

Abstract: A voltage selection circuit includes: a power detection circuit configured to compare an output voltage with a first input voltage and a second input voltage, respectively; a latch circuit, coupled to the power detection circuit, and configured to flip respective logic states of a pair of output signals when the output voltage is lower than either the first input voltage or the second input voltage; and a selection circuit, coupled to the latch circuit, and configured to use either the first input voltage or the second input voltage as the output voltage based on the respective logic states of the pair of output signals.

Abstract: A control system for controlling a heater includes a power converter, a sensor circuit, and a controller. The power converter supplies an adjustable power to the heater, and the sensor circuit is configured to measure an electrical characteristic of the heater. The controller is coupled to the power converter to control the power to the heater, and is configured to select a state model control, as an operation state of the heater, from among a plurality of defined state model controls. The controller controls the power supplied to the heater based on the operation state of the heater and on the electrical characteristics of the heater.

Abstract: A synchrophasor measurement method for a device configured to take synchronized measurements in a power system is provided. The synchrophasor measurement method includes receiving global positioning system (GPS)-synchronized samples of a signal sensed by the device from the power system; determining a level of distortion of the signal; selecting, based on the level of distortion, a computation method, the computation method being one of an improved zero-crossing (IZC) method and an enhanced phase-lock-loop (EPLL) method; performing the selected computation method to determine at least one parameter of the signal at a reporting frequency, which is at least twice a line frequency of the power system; and outputting, at the reporting frequency, the at least one parameter to an operator of the power system to allow the operator to perform at least one of a monitoring and a controlling of at least one element of the power system.

Abstract: Disclosed herein are systems and methods of calculating and mitigating time delays for electric power system samples received by remote data acquisition unit (RDAU), digitized, and transmitted to a receiving intelligent electronic device (IED). The IED may calculate time delays for various RDAUs, and establish wait windows for certain protection operations based on the samples needed for the protection operation and the calculated time delays for the various RDAUs. The IED may detect and report system or time signal anomalies based on changes to the calculated time delays from particular RDAUs.

Abstract: An electric utility metering system and method for detecting and to prevent the theft of electricity is disclosed. The system may include a public utility electric service source, a transformer attached to a master meter, a plurality of public utility customer units and an optional theft monitoring server. The master meter should be placed in a place that is inaccessible to customers. The master meter may further be configured to record the total electric power before distribution to each of the plurality of public utility customer units, and the system can compare that value to the quantity of electricity utilized by each of the customers serviced by the particular transformer. In another embodiment, standard customer meters are encased in a secure bracket on an electric power pole.

Abstract: An abnormality diagnosis apparatus includes a time series data obtaining unit for obtaining test data and variable data, the test data being obtained from the test object over a predetermined period of time and being time series data of a predetermined attribute value that dictates whether an abnormality is present in the test object, and the variable data corresponding to the test data for the predetermined period of time and being time series data regarding a variable affecting the attribute value, a superimposed image generating unit for superimposing a waveform of the test data and a waveform of the variable data to generate superimposed image data, and a determining unit for determining whether an abnormality is present in the test object based on the superimposed image data generated by the superimposed image generating unit.

Abstract: The invention relates to a device, method, computer program and computer program product for determining the equivalent series resistance of a power converter having power train parameters comprising a capacitance, an inductance and the equivalent series resistance, the device comprising a resistance determining unit that obtains a ripple voltage embedded in an output voltage of the power converter, determines a ripple current based on the output voltage, the inductance and operational switching data of the power converter, and estimates the equivalent series resistance of the power converter based on the ripple voltage, ripple current and the operational switching data.

Abstract: Cognitive analysis using applied analog circuits including receiving, by a circuit, a first set of data results and a second set of data results; charging a first capacitor on the circuit with a first unit of charge for each of the first set of data results that indicates a positive data point; charging a second capacitor on the circuit with a second unit of charge for each of the second set of data results that indicates a positive data point; applying a charge from the first capacitor and a charge from the second capacitor to an analog unit of the circuit; and generating a signal on a circuit output indicating that a ratio of the positive data points in the first set of data results to the positive data points in the second set of data results is greater than a statistical significance.

Abstract: Real time cognitive monitoring of correlations between variables including receiving, by a circuit, a first set of data results and a second set of data results, wherein each set of data results comprises binary data points; adding a unit of charge to a collection capacitor on the circuit for each of the first set of data results that indicates a positive data point; removing a unit of charge from the collection capacitor for each of the second set of data results that indicates a positive data point; and triggering a first sense amp on the circuit if the charge on the collection capacitor exceeds a high charge threshold, indicating that the positive data points in the first set of data results is greater than the positive data points in the second set of data results to a first statistical significance.

Abstract: Cognitive analysis using applied analog circuits including receiving, by a circuit, a first set of data results and a second set of data results; charging a first capacitor on the circuit with a first unit of charge for each of the first set of data results that indicates a positive data point; charging a second capacitor on the circuit with a second unit of charge for each of the second set of data results that indicates a positive data point; applying a charge from the first capacitor and a charge from the second capacitor to an analog unit of the circuit; and generating a signal on a circuit output indicating that a ratio of the positive data points in the first set of data results to the positive data points in the second set of data results is greater than a statistical significance.

Abstract: Real time cognitive monitoring of correlations between variables including receiving, by a circuit, a first set of data results and a second set of data results, wherein each set of data results comprises binary data points; adding a unit of charge to a collection capacitor on the circuit for each of the first set of data results that indicates a positive data point; removing a unit of charge from the collection capacitor for each of the second set of data results that indicates a positive data point; and triggering a first sense amp on the circuit if the charge on the collection capacitor exceeds a high charge threshold, indicating that the positive data points in the first set of data results is greater than the positive data points in the second set of data results to a first statistical significance.

Abstract: A sensor control arrangement may comprise a host controller, a remote sensor interface, a power/data bus extending between the host controller and the remote sensor interface, and an electromagnetic sensor configured to receive an AC signal from the host controller via the power/data bus, and send an a sensor signal to the remote sensor interface via the power/data bus.

Abstract: A three-dimensional surface potential distribution measurement system for measuring a surface potential of a measurement object comprises: a laser light source; a Pockels crystal exhibiting Pockels effect in which a refractive index changes depending on potential difference between the first end surface and the second end surface; a mirror disposed so as to be attached stationarily to the second end surface of the Pockels crystal; a photodetector to detect a light intensity of the laser light corresponding to the potential difference of the Pockels crystal; a housing that holds those elements; a three-dimensional motion-driver capable of three-dimensionally moving the housing; and a driving controller that controls the three-dimensional motion-driver.

Abstract: A circuit apparatus is a circuit apparatus used for a physical quantity measuring apparatus, including a detection circuit that performs physical quantity detection processing based on a detection signal from a physical quantity transducer and a processing circuit that performs processing based on an output signal of the detection circuit. The processing circuit obtains index information of floor noise generated in the detection circuit based on the output signal and performs abnormality detection of the physical quantity measuring apparatus based on the index information.

Abstract: A system and method of electronic component authentication or component classification can reduce the vulnerability of systems (e.g., satellites, weapons, critical infrastructure, aerospace, automotive, medical systems) to counterfeits. Intrinsic deterministically random property data can be obtained from a set of authentic electronic components, processed, and clustered to create a classifier that can distinguish whether an unknown electronic component is authentic or counterfeit.

Abstract: A method for fabricating a semiconductor structure includes when a chip under test releases an ESD current, detecting position information of photons emitted from the chip under test due to releasing of the ESD current; acquiring an image of an ESD path based on the detected position information of the photons; and determining whether the ESD path corresponding to the chip under test is normal based on the image of the ESD path and a layout image of the chip under test.

Abstract: An apparatus and method for managing the detection of faults in a wiring system. The wiring system is made up of supply wires and can include return wires. The supply wire connects a power supply to a load end. The fault detecting apparatus is positioned along the wire between the power supply and the load end and can include a first and second resistor, a voltage monitor, and an indicator.

Abstract: A wire tracing system includes a voltage output source having a director circuit with a plurality of output channels. Each of the output channels outputs a unique voltage signature. A voltage reader/data recorder includes a conductive probe and a data memory that is partitioned into a plurality of data bins. Each of the data bins in the voltage reader/data recorder is associated with one of the voltage signatures output via the output channels of the director circuit, and each of the data bins is configured to store information associated with each of a plurality of wires to which the output channels are respectively connectable. The system and method permit a single individual to rapidly discover the identities of individual wires and cables without having to repeatedly travel back and forth between those extremities.