Abstract: The object is to provide a lysis method, lysis treatment solution, detection method using an immunochromatographic device, and detection kit comprising an immunochromatographic device for detecting whether causative bacterium of mastitis is a staphylococcus or not by using milk of a livestock animal. There is provided a method for lysing a staphylococcus, which comprises the step of mixing a lysis agent containing a lytic enzyme, and at least one kind of ampholytic surfactant, and preferably further containing at least one kind of nonionic surfactant, with milk obtained form a livestock animal to lyse a staphylococcus existing in the milk. The lytic enzyme is preferably lysostaphin.

Abstract: Methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering COT inhibitors and/or COT neutralizers to a subject in need thereof are described. Methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS are also provided. Methods of diagnosing IBS by detecting the presence or absence of COT or a COT marker in a subject are described.

Abstract: In one aspect, a system for isolating particles includes a first array of magnets, a second array of magnets arranged generally in parallel with and spaced apart from the first array of magnets, and a micro fluidic device. The micro fluidic device includes a substrate, an inlet arranged on the substrate and configured to receive a fluid sample, an outlet arranged on the substrate, a first region of the substrate including a channel connected to the inlet, where the first region of the substrate is arranged to sandwich the channel between the first and second arrays of magnets.

Abstract: The present invention provides compositions and methods of detecting prostate cancer in the body fluids or tissues of patients. Prostate cancer is detected by measuring the level of glypican-1 in a body fluid sample. In one embodiment prostate cancer is detected by contacting a body fluid sample with an anti-glypican-1 antibody, such as MIL-38. The invention includes kits for detection of prostate cancer in a body fluid sample, comprising an anti-glypican-1 antibody and glypican-1 standards.

Abstract: The invention relates to biomarker assays based on protein/peptide biomarkers which show a pronounced differential behaviour between healthy and cancerous sample proteomes e.g. by mass spectrometric measurement and/or antibody-based assays such as an Enzyme-Linked Immunosorbent Assay (ELISA) determination of the protein biomarkers in serum, plasma or blood itself.

Abstract: The present disclosure relates to therapeutic methods and medical uses comprising the identification and use of cancer marker surrogates for increased polyamine expression. These markers may be used to identify patients who may be treated for diseases and disorders that are susceptible to polyamine synthesis inhibitors, and they can also be used to monitor therapeutic responses when such agents are used. More specifically, reduced levels of let-7 miRNA and elevated levels of LIN28 and HMGA2 proteins were found to correlate with elevated levels of polyamines and may be used for predicting the efficacy of cancer therapy using an ornithine decarboxylase (ODC1) inhibitor such as eflornithine (DFMO), suitably in combination with an NSAID such as sulindac.

Abstract: The present disclosure provides an achromatic colorimetric nanosensor, by using a mixture of nanoparticles with complementary colors. The color changes from an achromatic color to a chromatic color enables more clear color-transition and, thus, allows immediate analysis of the presence of a target analyte. Further, the present disclosure provides achromatic colorimetric nanosensor for detection of multiple analytes using plural nanoparticles via color changes from an achromatic to multiple chromatic colors.

Abstract: Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) and real-time data analysis methods are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.

Abstract: A method of purifying a glycan and/or a glycoconjugate comprising the steps of: (a) providing a stationary phase that comprises cotton; (b) applying a glycan and/or glycoconjugate-containing sample to the stationary phase; (c) washing the stationary phase with a first solvent; and (d) eluting the glycan and/or glycoconjugate from the stationary phase with a second solvent. A kit for purifying a glycan and/or glycoconjugate, the kit comprising: a stationary phase comprising cotton; and instructions for purifying a glycan and/or glycoconjugate according to the disclosed method.

Abstract: The present disclosure relates to a method for validating an existence of a urinary exosome including steps as follows. A urine sample is obtained from a subject. The urine sample is performing a serially centrifugation step to obtain a third precipitate. The third precipitate is resuspended with an extraction solvent to obtain a third mixture, and the third mixture is centrifuged to obtain a fourth supernatant. The fourth supernatant is analyzed by a mass spectrometry to detect whether there is a particular peptide therein.

Abstract: The present invention relates to new biomarkers and new sets of biomarkers for diagnosing a mood disorder, preferably depression or monitoring the effectiveness of therapy for said mood disorder.

Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.

Abstract: Improved methods and systems for diagnosing and for treating Cushing's syndrome and Cushing's Disease are provided herein, including methods and systems for concurrently treating Cushing's syndrome and differentially diagnosing Cushing's Disease from Ectopic Cushing's Syndrome in a patient with an established diagnosis of ACTH-dependent Cushing's syndrome. Treatment methods can use glucocorticoid receptor antagonists (GRAs), which differentially affect the ratio of cortisol to ACTH levels in patients having Cushing's Disease versus patients having Ectopic Cushing's Syndrome.

Abstract: The present invention provides methods, kits, and compositions for purifying HDL molecules from a sample (e.g., blood sample) using HDL tagging molecules comprising an HDL lipophilic core binding peptide (e.g., portion of ApoA1) and an affinity tag. The present invention also provides methods, kits, and compositions for detecting non-fragmented ApoA1 with mass spectrometry. The present invention further provides methods, kits, and compositions for tagging HDL molecules in a sample with detectably labeled ApoA1 molecules such that the ratio of detectably labeled ApoA1 molecules to native ApoA1 proteins may be determined.

Abstract: A method for processing sample tubes comprising biological samples is presented. The method comprises transporting a sample tube closed by a closure to a first work cell, removing the closure with a first decapping/recapping device; withdrawing from the sample tube a sample aliquot with a pipetting unit for processing by the first work cell and/or dispensing liquid into the sample tube and/or determining a sample parameter with an analytical unit, reclosing the sample tube with a closure with the first decapping/recapping device, transporting the sample tube to a second work cell, removing the closure with a second decapping/recapping device, and withdrawing from the sample tube a sample aliquot with a pipetting unit for processing by the second work cell and/or dispensing a volume of liquid into the sample tube and/or determining a sample parameter of the sample with of an analytical unit.

Abstract: A reagent container transfer mechanism transfers a reagent container selected from among reagent containers stored in a second reagent container storage section to a first reagent container storage section. A controller controls the reagent container transfer mechanism to transfer a reagent container from a second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.

Abstract: A laser strobe tachometer combines a strobe light with a laser speed sensor. The ability of the laser sensor to accurately determine machine speed enables a synchronous strobe rate to be determined without user intervention. Having locked onto the turning speed, the stroboscope can “freeze” the motion of the shaft, thereby allowing an operator to observe locations, such as on a keyway, flat or screw head, for the optimum placement of the laser spot to generate a once-per-revolution tachometer pulse.

Abstract: The calculation of the speed of a moving train is critical to being able to capture high speed resolution images of the undercarriage of a moving train using a camera in an associated application. The measurement must be extremely accurate and in real time so that an appropriately placed camera can capture images and transmit those images to a remote location.

Abstract: A measuring device having at least one at least approximately tubular probe device, by means of which an impact pressure, a total pressure or a dynamic pressure of a flow can be determined, and which is designed movable at least between a first operating state and a second operating state, where the probe device can be moved by an actuating unit in a controlled manner between the first operating state and the second operating state and held in said states.

Abstract: The present invention is a reel apparatus, system and method of using same that may utilize accelerometers for determining the rotational direction of an offshore reel as a component of maintaining a constant tension and constant slippage setting on the umbilical of the offshore reel as the radius to the umbilical varies and the deployment direction is reversed.

Abstract: A physical quantity sensor includes a movable electrode side fixed section, a first fixed electrode side fixed section which has a first fixed electrode section and a second fixed electrode side fixed section which has a second fixed electrode section, a movable mass section which has a first movable electrode section that has a portion facing the first fixed electrode section and a second movable electrode section that has a portion facing the second fixed electrode section and which is formed in a shape that encloses the movable electrode side fixed section, the first fixed electrode side fixed section, and the second fixed electrode side fixed section in planar view, and an elastic section which connects the movable electrode side fixed section and the movable mass section.

Abstract: A hot wire anemometer circuit has a calibrate subcircuit and an operate subcircuit which are selectively invoked via a user-activate mode switch. The calibrate subcircuit includes a detector configured to compare an amplified sensor voltage with an amplified drive voltage and output an indicator signal when the two voltages match. The drive voltage is derived from a user-adjusted drive resistance of a bridge subcircuit. The operate circuit includes a feedback loop which provides a signal to a bride node of a bridge circuit. After a sensor is connected to the anemometer circuit, the drive resistance is adjusted until the indicator signal is produced, signifying that the circuit is tuned and impedances are matched to prevent oscillations. A slewing network protects the sensor by shorting the drive resistance upon switching the anemometer circuit to the calibrate mode from the operate mode, and gradually restoring the drive resistance when switching back.

Abstract: According to this invention, a scanning probe microscope for scanning a surface of a sample with a probe by bringing the probe into contact with the surface of the sample, comprises a cantilever having the probe at its tip; a displacement detection unit to detect both a bending amount and a torsion amount of the cantilever; and a contact determination unit to determine a primary contact of the probe with the surface of the sample, based on the bending amount and the torsion amount detected by the displacement detection unit in all directions from an undeformed condition of the cantilever.

Abstract: Disclosed are an electrical contact for contacting an electrical component, an apparatus for testing an electrical component and a method of assembling an apparatus comprising an electrical contact for testing an electrical component.

Abstract: A probe card for a testing apparatus of electronic devices comprises at least one testing head which houses a plurality of contact probes, each contact probe having at least one contact tip suitable to abut onto contact pads of a device under test, and a support plate of the testing head associated with a stiffener and an intermediate support, connected to the support plate and suitable to provide a spatial transformation of the distances between contact pads made on the opposite sides thereof. Conveniently, the probe card comprises a support element which is joined to the intermediate support, this support element being made by means of a material having a greater stiffness than the intermediate support, thereby being able to provide local micro rectifications of the intermediate support.

Abstract: In order to measure a choke current through a choke, a flux density of a magnetic field which is emitted by the choke is consecutively measured at a sampling rate at a location which is fixed in relation to the choke. A magnetic bias of the choke is ascertained from the measurement values of the flux density at a known choke current which occurs during operation of the choke, wherein the choke current is known only in longer time intervals than the inverse value of the sampling rate during measurement of the flux density. The actual choke current is determined from the actual measurement values of the flux density taking into account the ascertained magnetic bias.

Abstract: Precision AC and DC voltage, current, phase, power and energy measurements and calibrations with current ranges from 1 uA to 20 kA and voltage ranges from 1V to 1000 kV are now performed with accuracies of better than one part per million. Continued demand for improved accuracy has led the inventors to address remnant magetization within the current comparators that form the basis of the measuring process within many of the measurement instruments providing the precision AC and DC measurements and calibrations. Accordingly, the inventors present current comparator and measurement system architectures together with control protocols to provide for correction of this remnant magnetization.

Abstract: A voltage sensor housing includes a top portion including a conductive top portion composed of conductive material and non-conductive top portions composed of non-conductive material, a bottom portion composed of non-conductive material, side portions composed of non-conductive material, wherein the top portion the bottom portion and the side portions define an interior area structured to hold a voltage sensor, and conductive side portions composed of conductive material and being disposed adjacent to the side portions. The conductive top portion is electrically floating and the conductive side portions are electrically grounded.

Abstract: The invention relates to a measuring resistor (1), in particular a low-resistance current-measuring resistor, comprising two terminal parts (2, 3) that consist of a conductor material for introducing and discharging a current, and a resistor element (4) that consists of a resistor material, wherein the resistor element (4) is arranged between the two terminal parts (2, 3) in the direction of the current and current flows through the resistor element (4). According to one variant of the invention, the measuring resistor (1) has several pairs of voltage-measuring contacts (7) for measuring the voltage falling across the resistor element (4) in order to be able to compensate metrologically for inhomogeneities in the current density.

Abstract: Embodiments of the present disclosure disclose a method for on-site monitoring of performance of energy devices. The method comprises measuring a value associated with one or more energy parameters of one or more energy devices in real time. The method further comprises comparing the measured value of the one or more energy devices with a predefined set of tolerance values corresponding to the one or more energy parameters of the one or more energy devices. The method further comprises indicating a result of the comparison on a display unit associated with the testing apparatus for on-site monitoring performance of the one or more energy devices.

Abstract: Systems and methods for detecting, decoupling and quantifying unresolved signals in trace signal data in the presence of noise with no prior knowledge of the signal characteristics (e.g., signal peak location, intensity and width) of the unresolved signals. The systems and methods are useful for analyzing any trace data signals having one or multiple constituent signals, including overlapping constituent signals, and particularly useful for analyzing data signals which often contain an unknown number of constituent signals with varying signal characteristics, such as peak location, peak intensity and peak width, and varying resolutions. A general signal model function is assumed for each unknown, constituent signal in the trace signal data.

Abstract: Nodes within a wireless mesh network are configured to monitor time series data associated with a utility network (or any other device network). One or more servers coupled to the wireless mesh network configures a data ingestion cloud to receive and process the time series data from the nodes to generate data streams. The server(s) also configure a distributed processing cloud to perform historical analysis on data streams, and a real-time processing cloud to perform real-time analysis on data streams. The distributed processing cloud and the real-time processing cloud may interoperate with one another in response to processing the data streams. Specifically, the real-time processing cloud may trigger a historical analysis on the distributed processing cloud, and the distributed processing cloud may trigger real-time processing on the real-time processing cloud. Any of the processing clouds may encompass edge nodes configured to perform real-time processing and generate data streams.

Abstract: An apparatus and a method for determining an antenna characteristic of an antenna under test in free space is disclosed. Measurement results of a transmitted power of a measurement signal transmitted between the reference antenna and an antenna under test are detected, wherein detecting takes place in the frequency domain. The detected measurement results are transformed into the time domain and a time-domain filter is applied to the measurement results converted into the time domain. A filter width of the time-domain filter is determined in dependence on a spatial distance between the reference antenna and the antenna under test. Measurement result portions that result due to a multipath propagation of the measurement signal between the reference antenna and the antenna under test are reduced or removed.

Abstract: A vehicle LED lighting outage detection circuit is disclosed for detecting a fault in the LED light and automatically increasing the power drawn from the light power supply in response to the fault. A complementary detection circuit is also disclosed for detecting the increased power draw and signaling a fault to an operator. The increased power draw can be selected to be in the form of a pulse that settles to a lower power draw state after a time to avoid excessive and wasteful power draw. The system can be mounted in a vehicle and, more particularly, to a semi-tractor truck, or installed as a retrofit system into an existing semi-trailer system.

Abstract: A probe system includes a heater and a control circuit. The heater includes a resistive heating element routed through the probe system. An operational voltage is provided to the resistive heating element to provide heating for the probe system. The control circuit is configured to provide the operational voltage and monitor a circuit frequency based on an element capacitance between the resistive heating element and a metallic sheath of the heater over time. The control circuit is further configured to determine remaining useful life of the probe system based on the circuit frequency.

Abstract: An operating point of one or more components in a processing device may be set using a leakage current estimated based on at least one of a rate of temperature overages or a rate of power overages. In some embodiments, a power management controller may be used to set an operating point of one or more components in the processing device based on at least one of a rate of temperature overages or a rate of power overages for the component(s).

Abstract: An audible ground fault detection device may include: a pulse-width modulation (PWM) circuit to produce a pulse signal in response to an occurrence of a ground fault; and a buzzer circuit to emit an audible sound in response to receipt of the pulse signal. The device may include a power circuit configured to transfer power from the power line to the PWM circuit when a ground fault occurs in a load of the power line, and not to transfer the power from the power line to the PWM circuit when no ground fault occurs in any load of the power line. When the PWM circuit has no power, it will not produce the pulse signal. The power circuit may also provide DC power to the buzzer circuit in response to the occurrence of the ground fault. The buzzer circuit may include a passive buzzer.

Abstract: Devices, systems and methods for use of an autonomously powered inductive time domain reflectometer sensor device are provided. A sensor device for a power line can include a first induction coil and a second induction coil coupled to the power line and a control device. The first induction coil can be configured to inject a first signal on a power line by inducing a first current on the power line. The second induction coil can be configured to inject a second signal on the power line by inducing a second current on the power line. The control device can be configured to control the second induction coil to inject the second signal to cancel a portion of the first signal. As a result of the second signal cancelling a portion of the first signal, the first signal can be configured to propagate in a single direction on the power line.

Abstract: For testing the connections (13) of batteries (8) that are connected in a battery module (5) to several bus bars (6, 7) that are electrically in parallel with their battery electrodes (10, 11) by a resistance measurer (16) comprising a pair of contact pins (17, 18), during a measurement a first batten’ electrode (10) is contacted by a first contact pin (17) and a point on the conductor arrangement (13, 6, 13, 10) connected to the first battery electrode (10) is contacted by the second contact pin.

Abstract: An insulation fault locating system using branch-selective feeding and a selective insulation monitoring system for a branched IT system is composed of multiple subsystems. For insulation fault location, a differential current measuring device, a test signal generator and a blocking device are arranged in each subsystem. The insulation monitoring device additionally includes a selective decoupling device arranged in each subsystem. Furthermore, a method determines a cross impedance between two subsystems on the basis of the insulation monitoring system.

Abstract: A mixed signal testing system capable of testing differently configured units under test (UUT) includes a controller, a test station and an interface system that support multiple UUTs. The test station includes independent sets of channels configured to send signals to and receive signals from each UUT being tested and signal processing subsystems that direct stimulus signals to a respective set of channels and receive signals in response thereto. The signal processing subsystems enable simultaneous and independent directing of stimulus signals through the sets of channels to each UUT and reception of signals from each UUT in response to the stimulus signals. Received signals responsive to stimulus signals provided to a fully functional UUT (with and without induced faults) are used to assess presence or absence of faults in the UUT being tested which may be determined to include one or more faults or be fault-free, i.e., fully functional.

Abstract: A semiconductor device manufacturing method includes forming a plurality of semiconductor chips on a main surface of a semiconductor wafer, electrically testing each of the semiconductor chips, dicing the semiconductor wafer into individual semiconductor chips and assembling each of the semiconductor chips into a package to be a semiconductor device, subjecting the packages to a burn-in test, determining whether each of the semiconductor chips requires the burn-in test to be performed, and generating a determination model for determining whether the semiconductor chips require the burn-in test to be performed.

Abstract: The invention relates to a tester apparatus of the kind including a portable supporting structure for removably holding and testing a substrate carrying a microelectronic circuit. An interface on the stationary structure is connected to the first interface when the portable structure is held by the stationary structure and is disconnected from the first interface when the portable supporting structure is removed from the stationary structure. An electrical tester is connected through the interfaces so that signals may be transmitted between the electrical tester and the microelectronic circuit to test the microelectronic circuit.

Abstract: Invention achieves reduced amount of terminals to control a test mode, test function and test results of a given standard for at least one “wrapped core” (40,100) (a core 100 surrounded by a wrapper boundary register (40) as “wrapper chain”). Test flexibility and speed of testing the core (100) are also improved. Suggested serial test interface comprises a state machine (210) and an instruction register (213) for wrapper-instructions, supplied through a single physical data input terminal (1a). The state machine (210) reads wrapper-instructions held by the instruction register (213) and generates on-chip wrapper control signals (30) of the given standard for the wrapper boundary register (40) of the core (100). At least one wrapper-instruction read from the Instruction Register (213) provides at least one wrapper control signal (30). The single input terminal (1a) also supplies an input test signal SDI for coupling to the wrapper boundary register (40) as on chip logical input test signal WSI.

Abstract: A device test architecture and a reduced device test interface are provided to enable efficient testing of embedded cores and other circuits within devices. The reduced device test interface is achieved using a double data rate (DDR) signaling technique between the tester and the device. The DDR test interface allows the tester to interface to test circuits within the device, such as IEEE 1500 and/or IEEE 1149.1 test circuits, to provide high test data bandwidth to the test circuits using a minimum of test interface signals. The test architecture includes compare circuits that allow for comparison of test response data to be performed within the device. The test architecture further includes a memory for storing the results of the test response comparisons. The test architecture includes a programmable test controller to allow for various test control operations by simply inputting an instruction to the programmable test controller from the external tester.

Abstract: A semiconductor apparatus includes a storage circuit, a processing circuit that performs processing using data stored in the storage circuit and writes data into the storage circuit as the processing is performed, a scan test circuit that executes a scan test on the processing circuit when the processing circuit does not perform processing, and an inhibit circuit that inhibits writing of data from the processing circuit to the storage circuit when the scan test on the processing circuit is executed.

Abstract: A logic built-in self-test (LBIST) circuit implements a pipeline scan enable launch on shift (LOS) feature. A first scan chain flip-flop has a scan enable input configured to receive a first scan enable signal. A logic circuit has a first input coupled to a data output of the first scan chain flip-flop and a second input coupled to receive the first scan enable signal. A second scan chain flip-flop has a scan input coupled to a scan output of the first scan chain flip-flop. A scan enable input of the second scan chain flip-flop is coupled to receive a second scan enable signal generated at an output of the logic circuit. The first and second scan chain flip-flops are clocked by a same clock signal.

Abstract: Accessory data collectors coupled to a switch-gear of a power system including at least one circuit breaker are provided. The data collector includes a sensor array configured to sense parameters associated with at least one accessory coupled to the at least one circuit breaker; and data storage configured to store the sensed parameters associated with the at least one accessory for a plurality of operational cycles of the at least one circuit breaker. Related methods and computer program products are also provided.

Abstract: A method and a corresponding system for detecting a malfunction in an electric drive unit. The method comprises the following steps: ascertain (S17) a current flow characteristic (1) of an electric drive unit; detect (S33) a gradient change in the current flow characteristic (1) at a first point in time (t=n); compare (S35, S39) the gradient change with a predefinable gradient change range; establish (S45) a malfunction in the electric drive unit if the gradient change is outside the predefinable gradient change range.

Abstract: A supply-voltage-fluctuation detecting apparatus includes a first detecting unit, a second detecting unit, a capacitor, and a fluctuation detecting unit. The first detecting unit and the second detecting unit detect fluctuations in voltage at a detected voltage input with respect to a detected ground input. A load unit that operates with power supplied from a battery and the first detecting unit are connected in parallel. A detected voltage input of the second detecting unit connects to a positive electrode of the battery. A detected ground input of the second detecting unit connects to a detected ground input of the first detecting unit via an impedance component. The capacitor is connected in parallel to the second detecting unit. The fluctuation detecting unit detects fluctuations in supply voltage when at least one of the first detecting unit or the second detecting unit detects fluctuations in voltage.