Abstract: A method for cellular analysis of cellular particles tagged with elemental tags, such as lanthanide-based elemental tags. Particles or element tags associated with particles can be vaporized, atomized, and ionized, such as with an inductively coupled plasma device or a glow discharge device. The vaporized, atomized, and ionized particles or element tags can be analyzed using mass spectrometry, such as using a time of flight mass spectrometer or a magnetic sector mass spectrometer. The amount of at least one element in individual particles can be measured through mass analysis. The amount of many different tags, for example at least five different tags, can be measured at the same time to facilitate multi-parametric analysis of cells and other particles. The vaporized, atomized, and ionized particles or element tags can be pretreated in an ion pretreatment system to filter out low mass ions, such as using a high-pass mass filter or a bandpass mass filter, to allow the elemental tags to pass therethrough.

Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.

Abstract: An analyzer of a component in a sample fluid includes an optical source and an optical detector defining a beam path of a beam, wherein the optical source emits the beam and the optical detector measures the beam after partial absorption by the sample fluid, a fluid flow cell disposed on the beam path defining an interrogation region in the a fluid flow cell in which the optical beam interacts with the sample fluid and a reference fluid; and wherein the sample fluid and the reference fluid are in laminar flow, and a scanning system that scans the beam relative to the laminar flow within the fluid flow cell, wherein the scanning system scans the beam relative to both the sample fluid and the reference fluid.

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

Abstract: A flow cytometry system having a flow channel defined through the thickness of a substrate is disclosed. Fluid flowing through the flow channel is illuminated by a first plurality of surface waveguides that are arranged around the flow channel in a first plane, while a second plurality of surface waveguides arranged around the flow channel in a second plane receive light after it has interacted with the fluid. The illumination pattern provided to the fluid is controlled by controlling the phase of the light in the first plurality of surface waveguides. As a result, the fluid is illuminated with light that is uniform and has a low coefficient of variation, improving the ability to distinguish and quantify characteristics of the fluid, such as cell count, DNA content, and the like.

Abstract: A device for conducting accelerated aging tests of a coating, notably an outer coating for an aircraft, in particular allowing the testing of the durability of the coating after having been subject to all kinds of stresses, is desired. An object of the disclosure thus relates to such a device including test chambers subject to different and/or independently controllable test parameters, and including light for generating photo-oxidation, the device including a support for a sample of the coating, displaceable between the chambers for generating mechanical stresses by thermal shocks. The disclosure herein finds applications in many fields of industry, and preferentially in the field of aeronautics.

Abstract: The present invention provides a plasma treatment detection indicator including a color-changing layer that changes color by plasma treatment, exhibiting excellent heat resistance, with the gasification of the color-changing layer or the scattering of the fine debris of the color-changing layer caused by the plasma treatment being suppressed to such a degree as to not affect the electronic device properties. Specifically, the present invention provides a plasma treatment detection indicator including a color-changing layer that changes color by plasma treatment, the color-changing layer containing at least one metal element selected from the group consisting of Mo, W, Sn, V, Ce, Te, and Bi in the form of a simple substance and/or an inorganic compound containing at least one metal element selected from the group consisting of Mo, W, Sn, V, Ce, Te, and Bi.

Abstract: An optical cell comprises first and second opposed reflecting elements, an entrance aperture in the first reflecting element and an exit aperture in the second reflecting element, wherein the entrance and exit apertures are configured such that, in operation, light introduced into the cell via the entrance aperture is reflected at least once by the second reflecting element and at least once by the first reflecting element before leaving the cell via the exit aperture.

Abstract: In one embodiment, a cavity-enhanced absorption spectroscopy system includes a cavity-enhanced absorbance cell in which a liquid sample can be provided for purposes of evaluation, the absorbance cell having diffusely reflective inner surfaces, a light source configured to emit light into the liquid sample within the absorbance cell, and a light detector configured to capture the light after it has passed through the liquid sample.

Abstract: A functional water concentration sensor includes: a container used to contain functional water; a light source that emits ultraviolet light; a phosphor that emits fluorescence when excited by ultraviolet light emitted from the light source and transmitted through the container; and a light-receiving element that receives the fluorescence, wherein a peak wavelength of the ultraviolet light emitted from the light source is in a predetermined range that includes an absorption peak specific to the functional water.

Abstract: A method for analyzing a gas sample conveyed in a drilling fluid involves liberating the gas sample from the drilling fluid, irradiating the gas sample with infrared radiation spanning a wavelength range in the near-infrared range, detecting absorption spectra associated with irradiating the gas sample, and determining a composition of the gas sample from the absorption spectra. The gas sample includes one or more of methane, ethane, propane, and butane, the detected absorption spectra are associated with irradiating each of the one or more of methane, ethane, propane, and butane, and the composition includes a concentration of any one or more of the methane, ethane, propane, and butane.

Abstract: A THz quantum cascade laser is used to investigate a target by directing a first beam of laser radiation from the laser at the target to thereby produce a second beam of laser radiation by interaction of the first beam with the target. Self-mixing of the first and second beams occurs within the laser and causes variations in a signal such as the operating voltage of the laser. An operating parameter of the laser that affects the interaction of the first beam with, the target is varied. The operating voltage is monitored and processed to determine phase and amplitude changes associated with material properties of the target. Consequently in one embodiment the invention provides for processing the variations in the signal to produce various images of the target.

Abstract: A hyperspectral imaging flow cytometer can acquire high-resolution hyperspectral images of particles, such as biological cells, flowing through a microfluidic system. A trajectory-based triggering system can be used that will only trigger the acquisition of a hyperspectral image when an appropriate particle or cell is crossing an imaging line, thereby saving valuable resources and time. The hyperspectral imaging flow cytometer can provide detailed spatial maps of multiple emitting species, cell morphology information, and state of health. An optimized system can image about 20 cells per second. The hyperspectral imaging flow cytometer enables many thousands of cells to be characterized in a single session.

Abstract: Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images.

Abstract: A device for photometric qualification of lateral flow quick tests by means of camera imaging includes an arrangement which manages with a pinhole aperture with a slot-shaped opening, which has been integrated into the basic housing body, in which the imaging has been optimized with a view to diffraction, imaging scale and integration behavior and in which the illumination and all the components are arranged in a housing which can be produced at a reasonable price, with the result that the quantifiability of customary LFA quick tests is made possible for the user with a sufficient precision. The device can transmit test-specific data automatically and contact-free with the help of electromagnetic waves via a transponder (RFID) and is thus suited for various tests and for quantification of LFA's. The device may work autonomously with an internal microcontroller (embedded system). The figures can be stored and optionally transmitted to a computer via an interface.

Abstract: A surface defect detecting method of optically detecting a surface defect of a steel material includes: an irradiation step of irradiating an examination target part with illumination light beams from different directions by using two or more distinguishable light sources; and a detection step of obtaining images by reflected light beams of the respective illumination light beams and detecting a surface defect in the examination target part by executing subtraction processing between the obtained images.

Abstract: A method and apparatus for scanning an integrated circuit comprising a plurality of time-synchronized laser microscopes, each of which is configured to scan the same field of view of an integrated circuit under test that generates a plurality of images of the integrated circuit under test, a data processor, coupled to the laser scanning microscope, for processing the plurality of images, comprising, a netlist extractor (NE) that produces one or more netlists defining structure of the integrated circuit under test.

Abstract: Provided is a method and system for dynamic shearographic inspection. The dynamic shearographic method allows nondestructive inspection of layered materials, in particular, those including a porous material. The method uses a load profile that increases and decreases the load, for example in a saw-tooth manner, without decreasing the load back down to the initial loading state, usually zero loading. Using the load profile in this manner constantly refreshes the reference speckle images to minimize background noise and allows defects to be distinguished from the noise.

Abstract: Collimator unit between X-ray tube and sample includes a plurality of collimator plates and displacement mechanisms, which move the collimator plates in interlocked fashion so as to locate the centers of through-holes on a line connecting X-ray focal point to an arbitrary point on the sample W, thereby suppressing the shading of X-rays due to the axis of the through-holes of the collimator unit becoming diagonal to the line connecting the X-ray focal point and the point on the sample.

Abstract: Disclosed is a method for quantitative analysis of heavy metals, particularly lead, arsenic, antimony or cadmium, in a liquid sample. Also disclosed is a method for quantitative analysis of heavy metals, particularly lead, arsenic, antimony or cadmium, in a powdery sample.

Abstract: A semiconductor gas sensor device includes a first cavity that is enclosed by opposing first and second semiconductor substrate slices. At least one conducting filament is provided to extend over the first cavity, and a passageway is provided to permit gas to enter the first cavity. The sensor device may further including a second cavity that is hermetically enclosed by the opposing first and second semiconductor substrate slices. At least one another conducting filament is provided to extend over the second cavity.

Abstract: A capacitor type humidity sensor is provided, where a reference capacitor (CR) is provided as an MIM (metal insulator metal) capacitor or a PIP (polysilicon insulator polysilicon) capacitor. The MIM capacitor or PIP capacitor is aligned in array structure to enable the trimming. The capacitor type humidity sensor includes a sensing capacitor (CS) connected between negative (?) drive voltage terminal (?VDRV) and an inverting terminal (?) of an operational amplifier, and a reference capacitor (CR) connected between positive (+) drive voltage terminal (+VDRV) and an output node (a) of the sensing capacitor (CS), wherein the sensing capacitor (CS) is configured to trim the reference capacitor (CR).

Abstract: A method of treating a gas sensor with an improved pulse discharge technique is provided by adding measurements of additional parameters, modification of the data processing algorithm, and establishing new calibration procedure in the low, intermediate and high concentration ranges of NOx. Additional measurements of the charge transfer during the charging pulses of the pulse discharge technique are made, and utilizing these data in combination with discharge rates during the pauses of the pulse discharge technique allows for combined measurements of O2 and NOx, in the combustion exhaust.

Abstract: A method for manufacturing a sensor element is provided for detecting at least one property of a measuring gas in a measuring gas chamber, in particular for detecting a proportion of a gas component in the measuring gas or a temperature of the measuring gas. The method includes the following steps: providing at least one solid electrolyte which includes at least one functional element; applying, at least in sections, at least one first layer made of a ceramic material to the solid electrolyte, the first layer having a first porosity after the application; and applying, at least in sections, at least one second layer made of a ceramic material, the second layer having a second porosity after the application, and the first layer differing from the second layer with respect to at least one material property. Moreover, a sensor element which is manufacturable according to this method is provided.

Abstract: According to one implementation, an ultrasonic test system includes at least one ultrasonic transducer, at least one ultrasonic sensor and a damage detection part composed of at least circuitry. The at least one ultrasonic transducer transmits an ultrasonic wave toward at least one test region. The at least one ultrasonic sensor detects the ultrasonic wave which has passed through the at least one test region. The damage detection part is configured to detect whether there is a damage in the at least one test region, based on a difference between a waveform corresponding to the ultrasonic wave detected by the at least one ultrasonic sensor and a reference waveform. The at least one ultrasonic transducer and the at least one ultrasonic sensor are disposed at positions which apart from each other with an interval longer than 300 mm.

Abstract: A magnetostrictive transducer assembly for generating a longitudinal elastic guided wave of a selected frequency and mode and for guiding the wave into an open end of a heat exchanger tube for testing the tube. The transducer assembly comprises a current-carrying coil of wire, a magnetostrictive material wrapped around the coil of wire, a mechanism for pressing the magnetostrictive material against an inner surface of the tube, and one or more biasing magnets placed in the vicinity of the current-carrying coil of wire and the magnetostrictive material.

Abstract: Provided is a supercritical fluid device equipped with a back pressure regulator for creating a pressurized state in which a mobile phase in a separation/extraction unit of an analysis flow passage is kept in a supercritical fluid state. One end of a pipe is connected to an outlet side of the back pressure regulator, and the other end of the pipe is open to the atmosphere. A heating unit is provided on the pipe, and the heating unit includes a plurality of electrically independent heaters arranged on mutually different portions of the pile along the pipe. A power supply controller is connected to the heaters, and the power supply controller is configured to supply heating power to one or more heaters selected among the plurality of heaters, but to not supply heating power to the other heaters.

Abstract: The present invention provides an ink composition for forming a color-changing layer that changes color by plasma treatment, the ink composition exhibiting excellent heat resistance, with the gasification of the color-changing layer or the scattering of the fine debris of the color-changing layer caused by plasma treatment being suppressed to the extent that electronic device properties are not affected. The invention provides an ink composition for forming a color-changing layer that changes color by plasma treatment, the ink composition comprising metal oxide particles containing at least one element selected from the group consisting of Mo, W, Sn, V, Ce, Te, and Bi, and a binder resin.

Abstract: Systems and methods of measuring properties of water in a water distribution system are provided. An analysis system, according to one embodiment, comprises a plurality of water sensors connected at various points to the water distribution system, each of the plurality of water sensors configured to measure a property of water. The analysis system also includes a computer server configured to communicate with the plurality of water sensors via a network and receive water measurement data from the plurality of water sensors. The computer server comprises a processor, a database configured to store the water measurement data, and a system health monitoring module configured to evaluate the health of the water distribution system to obtain health data. The analysis system further includes at least one client device configured to communicate with the computer server via the network and receive the health data from the computer server.

Abstract: An article is provided with a web of polymer fibers forming a scrim with openings between the polymer fiber elements. A particulate is distributed in, or on the polymer fiber in a quantity to make the scrim detectable by X-ray detection or magnetic detection. One or more layers are laminated to the scrim. A process for detecting a multi-layered laminated scrim-containing article with magnetic or X-ray detection equipment in a production setting is also provided. With process implementation article loss in a product can be detected thereby reducing precautionary product discard.

Abstract: Methods of characterizing ion-exchanged chemically strengthened Li-containing glasses include: a) measuring a mode spectrum of the glass sample; b) using the mode spectrum, estimating a first contribution to the center tension associated with a spike region and estimating a second contribution to the center tension due to a deep region only, wherein the deep region is assumed to follow a power-law stress profile; and c) determining a total center tension by adding of the first and second contributions to the center tension. The methods can be used for quality control during manufacturing of glass samples by comparing the total center tension to a center tension specification that provides optimum strength and durability.

Abstract: A system and method for augmenting or adding to the information used by an in-vitro diagnostic or other diagnostic device to generate results of a test is disclosed. A diagnostic device is capable of generating test results based on a sample, such as a sample provided by a patient, and is also capable of receiving additional information to enhance the results providable by the device. For example, an in-vitro diagnostic device is configured to read a lateral flow assay test, and is configured to receive additional diagnostic, network, test identification, or environmental information over a network. Using both the result of the diagnostic test and the additional information, the disclosed device provides more thorough, accurate, and reliable diagnostic information. The results generated by the device may be communicated to an appropriate remote device to enhance the results obtainable by such tests.

Abstract: Disclosed is a lens-attached tissue cell pressurization device that is selectively coupled to an objective lens to perform pressurization in an optical device configured measure a cell tissue using the objective lens, the lens-attached tissue cell pressurization device including: a body extending in a lengthwise direction of the objective lens such that at least a portion of the objective lens is inserted into the body and having a connector selectively fixed to the objective lens; and an indenter provided at a lower end of the body, having a penetration part formed at a center of the indenter, and pressurizing the cell tissue by a change in a relative location of the objective lens and the cell tissue.

Abstract: An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel.

Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

Abstract: Sample processing methods and systems to collect a biological sample. A device may be configured collect a predetermined volume of a sample in sample chamber, and seal the chamber upon activation. The device may be further configured to mix the mix the sample with a predetermined volume of a reagent and/or mix the sample and the reagent in a pre-determined ration.

Abstract: Disclosed herein, are methods of treating a neuroendocrine tumor (NET) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that inhibits a tropomyosin receptor kinase (Trk) protein, wherein the NET is associated with a Trk protein that has undergone a genetic translocation or is an NTRK gene fusion protein. Also disclosed herein are methods of treating a neuroendocrine tumor (NET) in an individual in need thereof, comprising: (a) obtaining a sample of NET genetic material from the individual; (b) determining whether the NET tumor comprises a NTRK translocation or gene fusion; and (c) administering to the individual a therapeutically effective amount of an agent that inhibits a tropomyosin receptor kinase (Trk) protein.

Abstract: Micropillar arrays for assaying differentiation of oligodendrocyte precursor cells into oligodendrocytes, ensheathment, and/or wrapping of the micropillars by the oligodendrocytes is provided. Also provided herein are methods of using the micropillar arrays for screening of candidate agents that promote differentiation of oligodendrocyte precursor cells into oligodendrocytes, ensheathment, and/or wrapping of the micropillars by the oligodendrocytes. A system comprising micropillar arrays and oligodendrocyte precursor cells are also provided.

Abstract: Disclosed are an enhancement solution for enhancing chemiluminescence, and a method for preparing a chemiluminescent solution. The method comprises Step A: dissolving methylglucamine in water, adjusting the pH to 8-9, then adding an N-alkyldimethylmannosamine quaternary ammonium salt, acridine orange, BSA, glycine, MgCl2, and ZnCl2 respectively to a diethanolamine solution, stirring to dissolve them, and diluting to a constant volume, to obtain an enhancement solution; and Step B: diluting a chemiluminescent substrate with the enhancement solution, to obtain a chemiluminescent solution. When used in the field of immunoassays, the enhancement solution of the present invention increases the sensitivity and linear range of detection, reduces the cost, and is free of contamination.

Abstract: A DNA ligand capable of structural changes upon binding to a target is used as a molecular switch with a SPFS (surface plasmon field-enhanced fluorescence spectroscopy) biosensor to realize one-step SPFS biosensing with rapid turnaround time. The SPFS biosensor has a thin metal film on a prism; when a light of a certain wavelength irradiates on the prism at a certain angle, a strong electrical field is generated at the surface of the metal film. The DNA is immobilized on the metal film surface with its free terminal modified with a fluorescent marker. Without the target, the DNA is folded and the fluorescent marker is located in the region of metal quenching near the metal surface. Upon binding to the target, the DNA is extended and the fluorescent marker is located in the region of enhanced electric field near the metal surface and emits a strong fluorescent signal.

Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. The methods of the invention utilize an immunostaining system allowing visualizing single target units in samples as distinct dots. In particular, the invention relates to methods and reagents for visualization and quantification of molecular targets immunostained in histological samples and use of said method and reagents in medical diagnostic. However, the visualization and quantification methods of the invention are applicable to a variety of targets in different samples and allow precise quantifying both relative and absolute amounts thereof.

Abstract: Novel grafted dinuclear metal complexes having formula (I) or of formula (II) wherein M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterising cellular microparticles.

Abstract: There is disclosed a system for electrical charge detection comprising a nanoFET device. Also disclosed is a method of electrical charge detection for single molecule sequencing. The method includes attaching a macromolecule or assemblies thereof to a gate of a nanoFET device and flowing in a solution of charge tags, where a charge tag includes a nucleotide attached to a charge complex. The method also includes incorporating one charge tag into the macromolecule or assemblies thereof and cleaving the charge tags from the macromolecule or assemblies thereof. The method further includes detecting at least one of current and voltage from the nanoFET device.

Abstract: Provided are molecule immobilization patterns and a method for forming the same, thereby reducing noise that may occur while analyzing a signal, being stable even at room temperature, and improving orientation of immobilized materials.

Abstract: Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described.

Abstract: Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described.

Abstract: The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.

Abstract: The present invention is related to a method for detecting a protein comprising: (1) providing a fusion protein, wherein the fusion protein comprises the protein which is fused with a secondary antibody detected protein tag, wherein the secondary antibody detected protein tag comprises at least one epitope selected from the Fc region of at least one primary antibody which is capable of being detected by a corresponding secondary antibody; (2) contacting the fusion protein with a secondary antibody which binds to the secondary antibody detected protein tag to form a protein/antibody complex; and (3) detecting the protein/antibody complex.

Abstract: This disclosure provides an antibody array for the analysis of the three-dimensional structure of a protein. It includes the development and production of the antibody array and methods of using the array to analyze the three-dimensional structure of a protein as well as to compare the three-dimensional structure of two proteins, for example, a therapeutic protein and a biosimilar, to determine if the two proteins are similar.

Abstract: A method for modification of solid substrates with proteins for efficient surface preconcentration of an analyte from multi-component samples before the detection based on desorption-ionization mass spectrometry and immunochemical assays. The claimed subject is a method of modification of surfaces used as substrates for desorption-ionization mass spectrometry and immunochemical assays. The method is based on electronebulization (electrospraying) of protein solution, depending on the intended application either enzymes, lectins, or antibodies. The formed charged electrospray is dried in real time by its passing through an evaporation compartment and the resulting beam of desolvated ions impacts onto the surface and binds to it firmly. Such modified surface can be then used for a selective interaction with an affinity partner of the deposited protein, its preconcentration or enzymatic modification followed by an analysis by means of desorption-ionization mass spectrometry or immunochemical assays.