Patents Issued in January 24, 2019
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Publication number: 20190024006Abstract: The object of the present invention is to provide a foreign substance removing lubricant composition having high foreign substance removing effects and being capable of improving the lubricating properties as compared to conventional lubricant compositions, a foreign substance removing lubricant composition applied member, and a method for using the foreign substance removing lubricant composition. The foreign substance removing lubricant composition of the present invention comprises a perfluoroalkyl group containing compound (S) having a perfluoroalkyl group or a fluoropolyether containing compound. As a result, foreign substance removing effects can be enhanced, and the lubricating properties can be improved as compared to the conventional lubricant compositions.Type: ApplicationFiled: January 26, 2017Publication date: January 24, 2019Applicant: Nippeco Ltd.Inventors: Yoshiro YOSHIDA, Yousuke KIMURA
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Publication number: 20190024007Abstract: It has been found that the balance between friction reduction in the engine crankcase and the maintenance of sufficient friction in the clutch assembly of a 4T motorcycle, where the engine crankcase and the clutch assembly are lubricating by the same lubricating oil composition from a common sump, can be achieved by use of a lubricating oil composition comprising a combination of molybdenum containing additive and ashless organic friction modifier.Type: ApplicationFiled: July 24, 2017Publication date: January 24, 2019Applicant: Infineum International LimitedInventors: Pei Yi Lim, Anne Wai-Yu Young
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Publication number: 20190024008Abstract: Provided is a lubricating oil composition containing a base oil (A) and an amine-based antioxidant (B), wherein the component (B) contains a phenyl-naphthylamine (B1), an alkylphenyl-naphthylamine (B2) and a di(alkylphenyl)amine (B3), the content of the component (B1) is 2.0 to 10.0% by mass relative to 100% by mass of the total amount of the component (B), the content of the component (B2) is 40.0 to 90.0% by mass relative to 100% by mass of the total amount of the component (B), and the content of the component (B3) is 8.0 to 50.0% by mass relative to 100% by mass of the total amount of the component (B). The lubricating oil composition maintains excellent oxidation stability even in long-term use in high-temperature environments, and has an excellent lifetime and is excellent also in a sludge preventing effect.Type: ApplicationFiled: January 16, 2017Publication date: January 24, 2019Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Shinji AOKI, Hidenori TORII
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Publication number: 20190024009Abstract: Provided is a lubricating oil composition containing a base oil (A); a molybdenum dithiophosphate (B1) in an amount of 400 ppm by mass or more as expressed in terms of a molybdenum atom; an organic metal-based detergent (C1) containing a metal atom selected from an alkali metal atom and an alkaline earth metal atom in an amount of 1,400 ppm by mass or less as expressed in terms of the metal atom; and a hindered amine-based antioxidant (D1) in an amount of 900 ppm by mass or more as expressed in terms of a nitrogen atom, with a sulfated ash content being 0.70% by mass or less. The lubricating oil composition may be one in which the detergency, the wear resistance, and the friction-reducing effect are improved with a well balance while reducing the ash content.Type: ApplicationFiled: February 24, 2017Publication date: January 24, 2019Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Tatsuya KUSUMOTO, Motoharu ISHIKAWA, Hiroshi OKI
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Publication number: 20190024010Abstract: A lubricant composition includes a lubricating base oil, a controlled release friction modifier, a dispersant, a viscosity modifier and a cleanliness booster. The controlled release friction modifier is an ashless, dispersant-stabilized, borated controlled release friction modifier including an ionic tetrahedral borate compound including a cation and a tetrahedral borate anion, wherein the tetrahedral borate anion includes a boron atom having two bidentate di-oxo ligands of C18 tartrimide.Type: ApplicationFiled: July 20, 2018Publication date: January 24, 2019Applicant: ExxonMobil Research and Engineering CompanyInventors: Michael L. BLUMENFELD, Douglas E. DECKMAN, Smruti A. DANCE, Charles L. BAKER, JR., James David BURRINGTON, David Paul PRISTIC, Ewan E DELBRIDGE
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Publication number: 20190024011Abstract: The invention relates to aqueous polymer dispersions comprising at least one polymer obtainable by the reaction of at least one monomer M1 of the general formula H2C?CH—C(O)OR (I), wherein R is an unbranched alkyl chain comprising from 18 to 22 carbon atoms, and optionally at least one monomer M2. The invention relates moreover to a method for the preparing of such aqueous polymer dispersion and the use thereof as pour point depressant for crude oil, petroleum, and petroleum products.Type: ApplicationFiled: March 8, 2017Publication date: January 24, 2019Inventors: Judith Christine BRAEUER, Kai GUMLICH, Stefan FRENZEL, Maria SOCHER, Jennifer Anne JACKSON, Edward BOHRES
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Publication number: 20190024012Abstract: A stable lubricant emulsion composition for use in engine and gear applications is provided. The emulsion includes a base petroleum oil, an aqueous salt solution that functions as a friction/wear modifier, and a polymeric non-ionic surfactant composition having a hydrophilic-lipophilic balance value in the range of 2.5 to 7 and an average molecular weight in the range of 1,000 to 3,000. The surfactant composition may include a polyester surfactant, a PIB succinimide surfactant, a PIB amine surfactant, or a mixture thereof.Type: ApplicationFiled: July 23, 2018Publication date: January 24, 2019Inventor: Daniel Daly
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Publication number: 20190024013Abstract: Disclosed is a method of treating a used hydrocarbon lubricant of ISO Viscosity Grade 46 or higher comprising oxidation products that adversely affect lubricant performance. The hydrocarbon lubricant has a Group II hydrocarbon oil or Group III hydrocarbon oil, optionally one or more lubricant additives, and an amount of varnish. The hydrocarbon lubricant is free of zinc-containing additives. The method comprises adding to the used hydrocarbon lubricant from about 2 percent by weight to about 20 percent by weight of a polyhydroxy polypropylene oxide homopolymer that has a hydroxyl number of from about 12 mg KOH/g to about 58 mg KOH/g as measured according to ASTM D4274.Type: ApplicationFiled: July 19, 2017Publication date: January 24, 2019Applicant: American Chemical Technologies, Inc.Inventor: Mark D. Latunski
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Publication number: 20190024014Abstract: A lubricating oil composition that includes a highly paraffinic base oil, a controlled release friction modifier (CRFM) and an effective amount of detergent. The CRFM includes an ionic tetrahedral borate compound comprising a cation and a tetrahedral borate anion which includes a boron atom, the boron atom having two bidentate di-oxo ligands of C18 tartrimide. The CRFM is a high stabilizer CRFM. The detergent includes a mixed magnesium and calcium detergent system having a calcium to magnesium ratio of less than 2:1.Type: ApplicationFiled: July 20, 2018Publication date: January 24, 2019Applicant: ExxonMobil Research and Engineering CompanyInventors: Michael L. BLUMENFELD, Douglas E. DECKMAN, Smruti A. DANCE, Charles L. BAKER, JR., James David BURRINGTON, Ewan E DELBRIDGE
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Publication number: 20190024015Abstract: A lubricant composition includes a controlled release friction modifier (CRFM), a highly paraffinic base stock, a dispersant and a detergent. The CRFM includes an ionic tetrahedral borate compound including a cation and a tetrahedral borate anion, wherein the tetrahedral borate anion comprises a boron atom having two bidentate di-oxo ligands of C18 tartrimide. The lubricant composition can also include at least one of a Group V co-base stock, an inorganic friction modifier, a viscosity modifier, and a cleanliness booster.Type: ApplicationFiled: July 20, 2018Publication date: January 24, 2019Applicant: ExxonMobil Research and Engineering CompanyInventors: Michael L. BLUMENFELD, Douglas E. DECKMAN, Smruti A. DANCE, Charles L. BAKER, JR., James David BURRINGTON, Ewan E. DELBRIDGE
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Publication number: 20190024016Abstract: Provided are: a lubricating oil composition containing a mineral oil (A) having a kinematic viscosity at 40° C. of 5 to 15 mm2/s and a flash point of 180° C. or higher, a synthetic oil (B) having a kinematic viscosity at 40° C. of 5 to 15 mm2/s and a flash point of 190° C. or higher, an amide compound (C) and a polyol ester compound (D), which has a low viscosity and fuel saving performance, which can be used in high-temperature environments, and which has excellent gear anti-seizing property and anti-shudder performance; and a lubrication method and a transmission using the lubricating oil composition.Type: ApplicationFiled: February 28, 2017Publication date: January 24, 2019Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Keiichi NARITA
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Publication number: 20190024017Abstract: A process for extraction of crude oil from distillers dried grain solubles and/or distillers dried grains and producing corn distillers meal that may be used as a livestock supplement is disclosed. For example, the corn distillers meal may be used as a crude protein supplement for use in a livestock feed diet or a poultry feed diet. The solvent extracted crude oil may be suitable for oleochemical processing for personal care and home care products, biodiesel production, and/or renewable diesel production from hydro-treating the extracted oil to make green diesel fuel.Type: ApplicationFiled: August 8, 2018Publication date: January 24, 2019Inventors: Keith Bruinsma, Donald Endres, Steven J. Furcich
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Publication number: 20190024018Abstract: A composition including a siloxane polymer. A method of treating and/or cleaning a situs using the same.Type: ApplicationFiled: July 19, 2018Publication date: January 24, 2019Inventors: Rajan Keshav Panandiker, Bernard William Kluesener
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Publication number: 20190024019Abstract: A siloxane polymer. A composition including the polymer. A method of treating and/or cleaning a situs using the same.Type: ApplicationFiled: July 19, 2018Publication date: January 24, 2019Inventors: Rajan Keshav PANANDIKER, Bernard William KLUESENER
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Publication number: 20190024020Abstract: A cleaning agent, preferably a dishwasher detergent, preferably a hand dishwashing detergent, having at least one protease and at least one amylase as defined herein. The invention also relates to the use of the type of cleaning agent for cleaning solid surfaces and to a method for cleaning hard surfaces using the described cleaning agent. The invention further relates to the use of a specific enzyme combination as defined herein for improving the cleaning action of a cleaning agent.Type: ApplicationFiled: September 19, 2018Publication date: January 24, 2019Applicant: Henkel AG & Co. KGaAInventors: Detlef Buisker, Marianne Schmeling, Johannes Zipfel, Timothy O'Connell
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Publication number: 20190024021Abstract: Disclosed herein are methods for improving safety and delivery of commercial application of cleaning compositions that include enzymes and other protein irritants. The methods reduce the mist and aerosolization of proteins so that inhalation and exposure to the same are reduced. According to the invention, when commercial pressurized sprayers are used to apply protein containing use cleaning compositions of up to 5 ppm protein, aerosolization is decreased to below 60 ng active protein per meter cubed. Applicants have also identified a specific metering tip/nozzle, dispense rate, and low pressure application of not more than 100 psi are critical to achieving the benefits of the invention.Type: ApplicationFiled: September 25, 2018Publication date: January 24, 2019Inventors: Nathan D. Peitersen, Charles Allen Hodge, Terrence Phillip Everson, Stephen James Engel
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Publication number: 20190024022Abstract: The invention concern compositions and methods that are effective at removing the soils on medical and dental instruments. The disclosed compositions provide improved cleaning compared to known enzymatic compositions for cleaning medical and dental instruments.Type: ApplicationFiled: December 21, 2016Publication date: January 24, 2019Applicant: Novozymes A/SInventor: Julien Coquillat
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Publication number: 20190024023Abstract: The present invention relates to a solid bleaching composition comprising at least one chlorinated bleaching and detergent agent selected among the dichloroisocyanurates and at least one optical brightener, characterised in that the pH of said composition is between 5 and 9, and in that the dissolution time of said composition in an aqueous solution is between 30 seconds and 20 minutes. The present invention likewise relates to the use of such a composition for bleaching a fabric, while protecting the textile fibres, as well as disinfecting and washing same.Type: ApplicationFiled: December 21, 2016Publication date: January 24, 2019Inventors: Marion OMONT-MANTEGHETTI, Jacques BROSSE, Maelle REYMOND
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Publication number: 20190024024Abstract: The invention relates to methods and liquid compositions suitable for high level disinfection (“HLD”) of medical instruments at close to ambient temperatures. The methods and compositions are also effective for digesting biological contaminants, and, surprisingly, can be used to clean and disinfect concurrently. Both cleaning and disinfection efficacy meet the criteria for cleaning and disinfection of medical devices. Use of compositions according to the invention enable reprocessing of instruments more quickly with greater energy efficacy, and greater convenience than prior art reprocessing methods. Compositions according to the invention are also useful for simultaneous cleaning and disinfecting other surfaces, for example in hospitals, food preparation areas and the like, or fabrics and the like such as are treated in hospital laundries.Type: ApplicationFiled: January 20, 2017Publication date: January 24, 2019Inventor: Alex Sava
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Publication number: 20190024025Abstract: Disclosed is a microcapsule comprising a benefit agent inside a water insoluble porous inner shell, an outer shell comprising at least one layer of cationic polymer and at least one layer of anionic polymer, and a non-ionic polysaccharide deposition aid.Type: ApplicationFiled: December 2, 2016Publication date: January 24, 2019Applicant: Conopco, Inc. d/b/a UNILEVERInventors: Craig Warren JONES, Changxi LI, Xiaoyun PAN, Yan WU, Yuanyuan ZHANG
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Publication number: 20190024026Abstract: Detergent compositions having surfactant systems that include alkyl ethoxylated sulfate surfactant (AES) and linear alkyl benzene sulfonate surfactant (LAS). Methods of treating fabric with such compositions.Type: ApplicationFiled: August 24, 2018Publication date: January 24, 2019Inventors: Sarah Ann DELANEY, Patrick Christopher STENGER, Meg Elizabeth HALL, Cheyne THOMAS
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Publication number: 20190024027Abstract: A sanitizing formulation for removing contaminated residue from metal, glass, porcelain, polymeric and textile surfaces includes a non-ionic surfactant; water soluble preservative; pH reducer, chelating agent; glycerin; water; and optionally an edible fragrance. Optionally, the exemplary formulation includes from about 2.7 to about 3.3 wt. % isopropyl alcohol, or about 3 wt. %. Optionally, the surfactant is selected from the group consisting of sodium benzoate and potassium sorbate. In another exemplary embodiment, convenient wipes are provided that are impregnated with the formulation.Type: ApplicationFiled: July 19, 2017Publication date: January 24, 2019Inventor: Lynn Dowdle
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Publication number: 20190024028Abstract: A beverage maker may include a fermentation device including a fermentation tank assembly having an opening, and a fermentation lid that opens and closes the opening, a refrigeration cycle including a compressor, a condenser, an expansion mechanism, and an evaporator formed therein such that a refrigerant circulates in the compressor, the condenser, the expansion mechanism, and the evaporator, which may adjust a temperature inside the fermentation tank assembly; a blower that may dissipate heat emitted by the condenser; a gas discharger connected to the fermentation device that discharges gas inside the fermentation device; and a rear cover provided behind the fermentation device which may include a through-hole such that both air blown by the blower and gas discharged from the gas discharger may be discharged through the through-hole.Type: ApplicationFiled: July 18, 2018Publication date: January 24, 2019Inventors: Jinpyo HONG, Shic YOON, Daewoong LEE
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Publication number: 20190024029Abstract: Certain embodiments and aspects relate to a photobioreactor including encapsulating photobioreactor units (EPU) within which a liquid medium and a gas are encapsulated. The liquid medium comprises at least one species of phototrophic or mixotrophic organism therein. The gas comprises a high concentration of carbon dioxide. Certain methods of using the EPUs for algal biomass production use automated function units.Type: ApplicationFiled: September 25, 2018Publication date: January 24, 2019Inventor: Xiaoxi Wu
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Publication number: 20190024030Abstract: A system to evaluate an embryo is provided. The system includes a measurement chamber having a bottom end. The measurement chamber is configured to receive an embryo such that the embryo descends towards the bottom end, and a culture medium is disposed within the measurement chamber. At least one sensor is configured to assess the embryo descending towards the bottom end and output a data signal representative of at least one characteristic of the embryo descending through at least a portion of the measurement chamber. A processor receives the data signal from the at least one sensor and determines one or more embryo properties based on the at least one characteristic.Type: ApplicationFiled: September 24, 2018Publication date: January 24, 2019Applicant: EMBRYOTICS LLCInventors: Justin WELLS, Cara WESSELS, Robert RANGEL
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Publication number: 20190024031Abstract: The present invention provides a culture device for tissue cell, and the culture device for tissue cell includes a tissue cell culture body. The porous material of the tissue cell culture body is composed by pore cavities which are classified according to the material pore size and cavity walls which are formed around the pore cavity at all levels. And the lower level small pore cavities are provided on the cavity wall formed around the upper level large pore cavities. The pore cavities within the same level are in communication with each other. And the pore cavities at all levels are also be in communication with each other. This device is particularly benefit for cell culture, so that tissue cells can freely and normally grow in three-dimensional space.Type: ApplicationFiled: August 9, 2016Publication date: January 24, 2019Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.Inventor: Lei Ye
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Publication number: 20190024032Abstract: The present invention relates to a tissue cell culture device which includes a tissue cell culture body. The porous material used as the tissue cell culture body is a porous metallic material which is formed by pore cavities classified by a pore size of the material and cavity walls surrounding to form the classified pore cavities. The cavity wall surrounding to form an upper level of large pore cavity is provided with a lower level of small pore cavity. The pore cavities in the same level are in communication with each other. The pore cavities in different levels are also in communication with each other. This device is particularly beneficial for cell cultivation and allows tissue cells to grow freely and normally in a three-dimensional space.Type: ApplicationFiled: August 9, 2016Publication date: January 24, 2019Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.Inventor: Lei Ye
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Publication number: 20190024033Abstract: Microfluidic devices for dissociating tissue, culturing, separating, manipulating, and assaying cells and methods for using the device are disclosed. Individual modules for tissue dissociation, cell, protein and particle separation, cell adhesion to functionalized, permissive micro-and nano-substrates, cell culturing, cell manipulation, cell and extracellular component assaying via metabolic and therapeutic compounds, compound titration, cell transfection, and micro-ELISA are described. Specialized micro-and nano-substrates and their methods of fabrication are also described. An integrated device is also disclosed. The devices and methods can be used for diagnostic applications, monitoring of disease progression, analysis of disease recurrence, compound discovery, compound validation, drug efficacy screening, and cell-based assays.Type: ApplicationFiled: July 19, 2017Publication date: January 24, 2019Applicant: CELLANYX DIAGNOSTICS, LLCInventors: Ashok C. CHANDER, David KONG
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Publication number: 20190024034Abstract: The present invention relates to a process for producing a composition comprising an aqueous medium and, disposed in the aqueous medium, a first volume of a first hydrogel, which process comprises: (i) providing a composition comprising a first hydrophobic medium and, disposed in the first hydrophobic medium, a first volume of a first hydrogel; (ii) disposing a volume of an aqueous composition comprising a hydrogel compound around the first volume of the first hydrogel; (iii) allowing the aqueous composition comprising the hydrogel compound to form a gel and thereby forming a hydrogel object, which hydrogel object comprises the first volume of the first hydrogel and a second volume of a second hydrogel, which second volume of the second hydrogel is disposed around the first volume of the first hydrogel; and (iv) transferring the hydrogel object from the first hydrophobic medium to an aqueous medium and thereby producing the composition comprising the aqueous medium and, disposed in the aqueous medium, the firType: ApplicationFiled: February 28, 2017Publication date: January 24, 2019Inventors: Hagan Bayley, Sam Olof, Alexander D. Graham
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Publication number: 20190024035Abstract: Bio-reactive systems for voltage controlled metabolism are described, that include electrochemical-electrostatic systems having a conventional three electrode cell modified with at least one additional gating electrode. The rate of a metabolic process occurring in at least one organism disposed on a working electrode is controllable by applying a gating voltage VG to the at least one gating electrode. A method for voltage controlled metabolism in a bio-reactive electrostatic cell that includes applying a gating voltage VG to at least one gating electrode is also described. The rate of a metabolic process may be controlled by altering at least one of the magnitude and polarity of the applied gating voltage VG. The method for voltage controlled metabolism may further be used to treat cancer and/or increase the rate of ethanol production by fermentation.Type: ApplicationFiled: July 26, 2018Publication date: January 24, 2019Inventor: Siu-Tung YAU
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Publication number: 20190024036Abstract: A culture apparatus including: a heat-insulated casing including an inner case surrounding a culture space, and an outer case, the heat-insulated casing having an opening; a box-shaped heat-insulated door to open and close the opening; and, one or more heaters provided to one or more inner surfaces of the inner case and an inner surface of an inner wall surface of the heat-insulated door, the inner wall surface facing the culture space when the door is closed; the heaters including one or more first heaters turned on when the interior of the culture space is at a first temperature to incubate a culture in the culture space and when the interior of the culture space is controlled at a second temperature to make the interior of the culture space, and second heaters to be energized when the interior of the culture space is controlled at the second temperature to sterilize the interior of the culture space.Type: ApplicationFiled: September 26, 2018Publication date: January 24, 2019Inventors: Tsugumasa HITOMI, Tomoyoshi TOKUMARU
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Publication number: 20190024037Abstract: In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.Type: ApplicationFiled: September 26, 2018Publication date: January 24, 2019Applicant: KANEKA CORPORATIONInventors: Shuhei TANIGUCHI, Nobuyoshi UMEDA, Takaaki SAKASHITA, Hiroshi SAKURAI
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Publication number: 20190024038Abstract: The present invention is directed to a method of purifying a protein of interest from the particulate matter of a fermentation broth comprising the step of purifying the protein of interest from the particulate matter of the fermentation broth, wherein the step of purifying the protein of interest from the particulate matter of the fermentation broth comprises one or more washing steps, which comprises contacting the particulate matter with a washing solution comprising one or more conditions that favor the solubilization of the protein of interest and/or the desorption of the protein of interest from the particulate matter.Type: ApplicationFiled: December 8, 2016Publication date: January 24, 2019Inventors: Katrin Treier-Marxen, Petra Deckert, Andreas Schaedler, Vaidotas Navickas, Volker Wengert, Thomas Kaeding
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Publication number: 20190024039Abstract: A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a speed sufficient to lyse the cells. Also disclosed is a device for lysing cells. The device includes a container having a magnetic stir element and a plurality of cell lysis beads disposed therein. The container is dimensioned to allow rotation of the magnetic stir element inside the container.Type: ApplicationFiled: September 24, 2018Publication date: January 24, 2019Inventors: Phillip BELGRADER, Benjamin HINDSON
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Publication number: 20190024040Abstract: The present invention provides a non-naturally occurring microbe capable of growing in a medium comprising methanol, comprising a heterologous polynucleotide encoding a heterologous methanol dehydrogenase (MDH) derived from a Corynebacterium organism (Cor), wherein the MDH is expressed in the microbe, and wherein the MDH exhibits a Km of no more than 3 mM for methanol. Also provided are uses of the non-naturally occurring microbe for oxidizing methanol and producing a metabolite as well as the preparation of the non-naturally occurring microbe.Type: ApplicationFiled: January 13, 2017Publication date: January 24, 2019Applicant: University of DelawareInventors: Eleftherios T. Papoutsakis, William Brian Whitaker, Robert Kyle Bennett
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Publication number: 20190024041Abstract: The present disclosure provides methods, and related kits, for directing cell attachment and spreading on a substrate and inducing isotropic spreading of cells; provides methods, and related kits, for cell sorting; and further provides methods, and related kits, for guided induction of stem cell differentiation.Type: ApplicationFiled: July 18, 2017Publication date: January 24, 2019Inventor: Shengyuan Yang
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Publication number: 20190024042Abstract: The present disclosure relates to a phage-based matrix for inducing stem cell differentiation and a method for preparing the same. More specifically, the present disclosure relates to a composition for inducing differentiation of stem cells, which includes a phage-based matrix in which a gradient of stiffness is controlled by crosslinking a recombinant phage with a polymer, and a method for preparing a phage-based matrix for stem cell differentiation. According to the present invention, the method of the present disclosure provides a physical and mechanical niche environment created by the formation of a nanofibrous structure of the phage whose stiffness is controlled, thereby promoting the differentiation of stem cells into target cells. Therefore, it can be applied to a tissue matrix platform as a variety of conventional tissue engineering materials.Type: ApplicationFiled: February 27, 2018Publication date: January 24, 2019Inventor: So Young Yoo
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Publication number: 20190024043Abstract: The present invention provides biomatrix scaffolds for industrial scale dispersal.Type: ApplicationFiled: April 12, 2018Publication date: January 24, 2019Applicant: The University of North Carolina at Chapel HillInventors: Marsha Lynn ROACH, Richard Harold MALAVARCA, Yunfang WANG, Lola M. REID
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Publication number: 20190024044Abstract: The present invention relates to directed differentiation and maturation of mammalian hepatocytes, such as human hepatocytes. The hepatocyte obtained in accordance with the present invention show a phenotype which is more similar to that of primary hepatocytes than previously shown. In particular, the present invention relates to exposure of mammalian hepatocytes, such as human hepatocytes, to at least one maturation factor selected from the group consisting of Src kinase inhibitors, vitamin D including precursors, metabolites and analogs thereof, hypoxia inducing compounds, sphingosine and sphingosine derivatives, activators of peroxisome proliferator-activated receptors (PPARs), platelet-activating factor (PAF), PKC inhibitors, and combinations thereof.Type: ApplicationFiled: June 3, 2016Publication date: January 24, 2019Applicant: Takara Bio Europe ABInventor: Barbara Kuppers-Munther
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Publication number: 20190024045Abstract: A microfluidic chip is provided for self-sorting highly motile, morphologically normal sperm cell with high DNA integrity from a fresh semen sample. The sperm self-sorting microfluidic chip has one or more inlet chambers, and sperm collection outlet chamber(s), and the middle of the channel features various micro-fabricated structures in different geometrical shapes and orientations, with varying periodicities and patterns, such as an array of micro-fabricated pillars that facilitate the transport of the active and healthy sperm into the outlet chamber.Type: ApplicationFiled: January 22, 2017Publication date: January 24, 2019Inventors: Utkan Demirci, Erkan Tüzel, James Leonard Kingsley, Thiruppathiraja Chinnasamy
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Publication number: 20190024046Abstract: Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising one or more rosette structures. Preferably, the methods provided herein direct differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising a singular neural rosette structure that is comparable to at least a portion of the developing human neural tube. Also described are engineered neural tissue preparations comprising biomimetic neural tissues comprising a singular rosette structure having regional neural progenitor phenotypes.Type: ApplicationFiled: July 24, 2018Publication date: January 24, 2019Inventors: Randolph Scott Ashton, Gavin T. Knight
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Publication number: 20190024047Abstract: Media which are substantially free of one or more amino acids selected from the group consisting of L-glutamine, L-asparagine, and L-aspartic acid are useful for producing a neural stem cell and/or a neural progenitor cell with promoted neuronal differentiation potency.Type: ApplicationFiled: September 27, 2018Publication date: January 24, 2019Applicant: AJINOMOTO CO., INC.Inventors: Takuya MATSUMOTO, Ikue HARATA, Sho SENDA
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Publication number: 20190024048Abstract: The present application provides pharmaceutical compositions comprising a population of mononuclear-enriched cells in an early-apoptotic state, methods for the production of said compositions and uses thereof in the treatment of diseases characterized by pathological immune responses. The pharmaceutical compositions may be used in treatment of conditions such as, but not limited to, graft versus host disease (GVHD) and autoimmune diseases including but not limited to inflammatory bowel disease, gout and arthritis.Type: ApplicationFiled: July 29, 2018Publication date: January 24, 2019Applicant: ENLIVEX THERAPEUTICS LTDInventors: Dror MEVORACH, Inna Reiner
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Publication number: 20190024049Abstract: Disclosed herein are methods for selectively expanding cells expressing chimeric antigen receptors and enriching cells expressing chimeric antigen receptors in compositions and methods of treating HIV infection in subjects by administering the expanded and/or enriched cells.Type: ApplicationFiled: January 27, 2017Publication date: January 24, 2019Applicant: The Regents of the University of CaliforniaInventors: Otto O. Yang, Ph.D., Ayub Ali, Hwee Ng, Scott G. Kitchen, Jerome A. Zack, Irvin Chen
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Publication number: 20190024050Abstract: A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation, (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.Type: ApplicationFiled: August 9, 2018Publication date: January 24, 2019Inventors: Cassian YEE, Yongqing LI
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Publication number: 20190024051Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.Type: ApplicationFiled: July 23, 2018Publication date: January 24, 2019Inventors: John C. CAMBIER, Yosef REFAELI, Sara Ann JOHNSON, Brian Curtis TURNER
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Publication number: 20190024052Abstract: The present disclosure provides methods, and related kits, for directing cell attachment and spreading on a substrate and inducing isotropic spreading of cells; provides methods, and related kits, for cell sorting; and further provides methods, and related kits, for guided induction of stem cell differentiation.Type: ApplicationFiled: July 18, 2017Publication date: January 24, 2019Inventor: Shengyuan Yang
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Publication number: 20190024053Abstract: This invention provides a system for obtaining cells of the chondrocyte lineage by differentiating primate pluripotent stem cells. The process involves culturing the cells as a micromass or other aggregate form in a cocktail of differentiation agents that facilitates outgrowth of the desired cell type. Progeny are capable of synthesizing Type II collagen or aggrecan, or other products that are characteristic of the chondrocyte lineage. Chondrocytes and chondrocyte precursor cells obtained according to this disclosure are suitable for use in both research and clinical therapy.Type: ApplicationFiled: January 22, 2018Publication date: January 24, 2019Inventor: R. Scott Thies
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Publication number: 20190024054Abstract: Provided is a method of preparing a somatic cell including converting a differentiated somatic cell of a mammal to other somatic cell by culturing the differentiated somatic cell in a medium for inducing differentiation of the somatic cell other than the differentiated somatic cell in the presence of a TGF-? pathway inhibitor.Type: ApplicationFiled: October 20, 2016Publication date: January 24, 2019Applicant: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATIONInventors: Kenta YAMAMOTO, Tsunao KISHIDA, Yoshihiro SOWA, Toshiro YAMAMOTO, Osam MAZDA
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Publication number: 20190024055Abstract: A method for promoting anti-inflammatory properties and for improving repair ability of a tissue containing mesenchymal stem cells (MSCs) includes causing a mechanical activation by applying a orbital shaking force on an adipose tissue lipoaspirated or removed from a body.Type: ApplicationFiled: December 28, 2016Publication date: January 24, 2019Inventor: Alfredo Gorio