Abstract: Methods, systems, computer-readable media, and apparatuses for obtaining at least one bodily function measurement are presented. A mobile device includes an outer body sized to be portable for user, a processor contained within the outer body, and a plurality of sensors physically coupled to the outer body. The sensors are configured to obtain a first measurement indicative of blood volume and a second measurement indicative of heart electrical activity in response to a user action. A blood pressure measurement is determined based on the first measurement and the second measurement. The sensors also include electrodes where a portion of a user's body positioned between the electrodes completes a circuit and a measurement to provide at least one measure of impedance associated with the user's body. A hydration level measurement is determined based on the measure of impedance.

Abstract: An apparatus, system, and method monitors the motion, breathing, heart rate and sleep state of subjects, e.g., humans, in a convenient, non-invasive/non-contact, and low-cost fashion. More particularly, the motion, breathing, and heart rate signals are obtained through processing applied to a raw signal obtained in a non-contact fashion, typically using a radio-frequency sensor. Periods of sleep disturbed respiration, or central apnea can be detected through analysis of the respiratory signal. The mean heart rate, and derived information, such as the presence of cardiac arrhythmias can be determined from the cardiac signal. Motion estimates can be used to recognize disturbed sleep and periodic limb movements. The sleep state may be determined by applying a classifier model to the resulting streams of respiratory, cardiac and motion data. A means for display of the sleep state, respiratory, cardiac, and movement status may also be provided.

Abstract: Described herein are compositions and methods for diagnosing, imaging, and quantifying non-calcified atherosclerotic plaque. Embodiments of compositions described herein comprise mannosylated dextran compounds along with other carbohydrate molecules comprising, for example, a diagnostic agent and a diagnostic moiety. The compounds and methods embodied herein produce superior localization and results for imaging, anatomically locating, and quantifying non-calcified atherosclerotic plaque.

Abstract: Systems for monitoring left atrial pressure using implantable cardiac monitoring devices and, more specifically, to a left atrial pressure sensor implanted through a septal wall are presented herein.

Abstract: Systems for monitoring left atrial pressure using implantable cardiac monitoring devices and, more specifically, to a left atrial pressure sensor implanted through a septal wall are presented herein.

Abstract: A blood pressure measuring apparatus includes a sensor configured to acquire a user image of a user, and a processor configured to determine, based on the user image, relative position information of a blood pressure measuring point of the user, the relative position information including a distance between a reference point of the user and the blood pressure measuring point, and measure a blood pressure of the user by correcting an effect of a hydrostatic pressure on the blood pressure, based on the relative position information that is determined.

Abstract: The wrist sphygmomanometer includes a wristband, an inflatable bladder, a measuring unit and a pressure sensing unit. The wristband has an inner surface that is adapted to contact a human wrist. The inflatable bladder is mounted inside the wristband, and has a measurement point adapted to correspond in position to a point of radial pulse on the human wrist. The measuring unit is mounted on an outer surface of the wristband and is connected to the inflatable bladder. The pressure sensing unit includes a pressure sensor mounted at the measurement point of the inflatable bladder, and a wire electrically interconnecting the measuring unit and the pressure sensor.

Abstract: Disclosed is finger cuff that is connectable to a patient's finger to be used in measuring the patient's blood pressure by a blood pressure measurement system. The finger cuff may comprise a fixed shell and a bladder. The fixed shell may have a finger cavity, in which the finger cavity of the fixed shell may be placed around a patient's finger to surround a large portion of the patient's finger including the middle knuckle to reduce finger movement, and in particular, to reduce relative movement between the middle phalanx and the proximal phalanx. Further, the fixed shell includes a support member that extends away from the finger cavity to abut against the underside of the patient's hand to reduce bending of the finger relative to the hand.

Abstract: A wearable physiological sensor has a housing and a gas-permeable support structure carried by the housing, which contacts the skin of the subject. An air space is provided between the support structure and the housing. Movement of the support structure relative to the housing is sensed. This provides a sensor which is comfortable for the subject and provides good sensitivity in that motion being detected (e.g. an arterial pulse) only needs to impart kinetic energy to the support structure, with a relatively low inertia.

Abstract: In an embodiment, PhotoPlethysmoGraphy (PPG) signals are processed by detecting peaks and valleys in the PPG signal, segmenting the PPG signal to provide a time series of PPG waveforms located between two subsequent valleys in the PPG signal, applying to the waveforms in the time series pattern recognition with respect to a reference PPG waveform pattern produced based on a mathematical model of the PPG signal by assigning to the waveforms in the time series a recognition score. A resulting PPG signal is produced by retaining the waveforms in the time series having an assigned recognition score reaching a recognition threshold, and discarding the waveforms in the time series having an assigned recognition score failing to reach the recognition threshold.

Abstract: A biometrics device measures a biometric quantity of a body of a user while the user is in motion. The biometric device includes a sensor to measure the biometric quantity of the user and creates a sensed biometric signal. A coupling device couples the sensor to the body of the user. An emitter is electrically connected to the sensor, receives the sensed biometric signal, and emits an output signal to be received by the user such that the user can understand the biometric quantity as the user continues the motion.

Abstract: A wrist apparatus as a portable electronic apparatus includes a case, a solar battery that is provided in the case, and has an outer circumference along an outer edge of the case and an inner circumference of which a circumferential length is shorter than a circumferential length of the outer circumference, and an acceleration sensor that is provided in the case, in which the solar battery is disposed outside an outer edge of the acceleration sensor in a plan view of a light reception surface of the solar battery.

Abstract: An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.

Abstract: A nanowire probe sensor array including a substrate with a metal pattern thereon. An array of semiconductor vertical nanowire probes extends away from the substrate, and at least some of probes, and preferably all, are individually electrically addressed through the metal pattern. The metal pattern is insulated with dielectric, and base and stem portions of the nanowires are also preferably insulated. A fabrication process patterns metal connections on a substrate. A semiconductor substrate is bonded to the metal pattern. The semiconductor substrate is etched to form the neural nanowire probes that are bonded to the metal pattern. Dielectric is then deposited to insulate the metal pattern.

Abstract: A partially-masked electrode includes a conductive material and an insulated coating having an outer surface. The insulated coating defines a contoured opening that exposes or reveals an area of the conductive material, wherein the contoured opening has an upper perimeter at the outer surface of the insulated coating. When the upper perimeter of the insulated surface coating is placed in contact with a tissue of interest, wherein the tissue of interest is proximate a blood pool, the insulated coating creates a seal between the blood pool and the contoured opening so that no blood in the blood pool can contact the conductive material. This seal reduces or eliminates the reception of far field effects in the blood pool by the electrode, making it easier to locate and diagnose unhealthy tissue.

Abstract: An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.

Abstract: n some embodiments, an open-gate pseudo-conductive high-electron mobility transistor (PC-HEMT) includes a multilayer hetero-junction structure made of III-V single-crystalline or polycrystalline semiconductor materials. This structure includes at least one buffer layer and a barrier layer, and is deposited on a substrate layer. The PC-HEMT further includes a two-dimensional electron gas (2DEG) or two-dimensional hole gas (2DHG) conducting channel formed at the interface between the buffer layer and the barrier layer, source and drain contacts, either ohmic or non-ohmic, connected to the 2DEG or 2DHG conducting channel, electrical metallizations for connecting the PC-HEMT to an electric circuit, and an open gate area between the source and drain contacts.

Abstract: In some embodiments, a microelectronic sensor includes an open-gate pseudo-conductive high-electron mobility transistor and used for air quality monitoring. The transistor comprises a substrate, on which a multilayer hetero-junction structure is deposited. This hetero-junction structure comprises a buffer layer and a barrier layer, both grown from III-V single-crystalline or polycrystalline semiconductor materials. A two-dimensional electron gas (2DEG) conducting channel is formed at the interface between the buffer and barrier layers and provides electron current in the system between source and drain electrodes. The source and drain contacts are non-ohmic (capacitively-coupled) and connected to the formed 2DEG channel and to the electrical metallizations, the latter are placed on top of the transistor and connect it to the sensor system. The metal gate electrode is placed between the source and drain areas on or above the barrier layer, which may be recessed or grown to a specific thickness.

Abstract: The present document relates to a method for generating a contrast enhancement map of a portion of a patient. The method comprises acquiring a magnetic resonance, MR, quantification sequence of the portion, wherein the MR quantification sequence comprises quantification information of a longitudinal R1 relaxation rate, R1, and proton density, PD, of the portion, generating an R1 map of the portion based on the MR quantification sequence, wherein a value of R1 for each voxel of the R1 map is determined, generating a PD map of the portion based on the MR quantification sequence, wherein a value of PD for each voxel of the PD map is determined, estimating a R1? map of the portion, based on the PD map and a predetermined relationship of R1 and PD of the portion, wherein an estimated value of R1 for each voxel of the R1? map is calculated, generating a delta R1 map based on the R1 map and the R1? map.

Abstract: A method to automatically align magnetic resonance (MR) scans for diagnostic scan planning includes acquiring a three-dimensional (3D) localizer image of an anatomical object. One or more initial landmarks are identified in the 3D localizer image using a landmarking engine. One or more main axes associated with the anatomical object are identified based on the one or more initial landmarks. The 3D localizer image is registered to a canonical space based on the main axes associated to yield a registered 3D localizer image. The landmarking engine is applied to the registered 3D localizer image to yield one or more updated landmarks. A plurality of reference points for performing a MR scan are computed based on the one or more updated landmarks.

Abstract: A novel medical imaging system that is based on radio-wave signals at microwave frequencies and has unique properties. The system can be used for various diagnostic applications such as breast cancer detection, brain stroke detection, and assessment of internal bleeding (trauma emergencies).

Abstract: A method for assessing a patient may involve performing a first diagnostic procedure on the patient. The first diagnostic procedure may involve securing a volumetric integral phase-shift spectroscopy (VIPS) device to the patient's head, measuring an intracranial bioimpedance with the VIPS device, and detecting an asymmetry based on the measured intracranial bioimpedance. The method may further involve performing a second diagnostic procedure on the patient using an additional diagnostic device, receiving first patient data from the first diagnostic procedure and second patient data from the second diagnostic procedure in a computer processor, processing the first patient data and the second patient data with the computer processor, and generating an assessment of the patient with the computer processor, based at least in part on the processed first patient data and second patient data.

Abstract: Apparatus and method for imaging a patient in an MRI system. This includes a frame, and at least one assembly that includes a patient-interface positioner connected to a reference position on the frame, a first lockable joint on the positioner; and a patient interface connected to a patient-proximal end of the positioner by a second joint, wherein the first patient-interface is moveably positioned to a selected pitch angle, a selected yaw angle, and a selected one of a plurality of distances relative to the reference position on the frame. The first lockable joint is configured to be tightened to yieldably hold the first patient-interface at the selected pitch and yaw angles, and at the selected one of the plurality of distances, relative to the reference position. Optionally a second substantially similar patient-interface and assembly are provided. The earpiece(s) optionally include audio transducer(s) and/or RF coil(s).

Abstract: Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of tracking and locating the same are provided.

Abstract: An interconnect ring is used in attaching the leadwires to the coil wire ends of a microminiature sensor. The interconnect ring is affixed directly to an outside surface of either the core or the coil wire of the microminiature sensor. At least the two flexible ends of the coil wire are electrically joined to metal pads on the interconnect ring. Thereafter, the microminiature sensor can be handled with minimal risk of breakage, shorting or dislodging of the ends of the coil wire. Two other metal pads on the interconnect ring are left open for subsequent attachment of leadwires which can run the length of the catheter device in which the microminiature sensor is used.

Abstract: A handheld device for locating a foreign body in or beneath a patient's skin comprises one or more sensors that each generate a magnetic or electromagnetic field and a signal reflecting the location and/or size and/or depth of a foreign body and a processor that receives and processes each signal and generates a signal to an operatively connected display. The display that receives the display signal shows the location and/or size and/or depth of the foreign object.

Abstract: Methods and systems are described to obtain and analyze one or more gas samples from the breath of a person, and organizing the samples in a sample registry for subsequent analysis. This technique solves the various problems that are associated with targeting an individual breath for analysis, and allows for additional versatility and options in the analysis process.

Abstract: An example apparatus for detecting respiratory rates includes an audio receiver to receive audio including respiratory sounds. The apparatus also includes an adaptive low-pass filter to process the audio using an adaptive bandwidth based on a mean breath rate to generate an envelope. The apparatus further includes a peak detector to detect a plurality of peaks from the envelope. The apparatus includes a respiratory rate calculator to calculate a respiratory rate based on the detected plurality of peaks.

Abstract: Aspects of the subject disclosure may include, for example, obtaining a first plurality of circumference measurements, each of the first plurality of circumference measurements corresponding to a first circumference around a limb of a person at a respective one of a plurality of locations of the limb, each of the first plurality of circumference measurements being obtained from a respective one of a plurality of elastic measurement elements that is positioned at a respective one of the locations; determining, based upon the first plurality of circumference measurements, a first geometric profile along a length of the limb; and outputting data representing the first geometric profile. Other embodiments are disclosed.

Abstract: A stroke detection device (50, 100), and associated methods of operation, for early detection of ischemic stroke. The device (50, 100) includes a fiberoptic port (20, 102) connected to an end of a fiberoptic catheter (22, 120), the catheter (22, 120) including a first optical fiber (26, 122) and a second optical fiber (28, 124) each extending along at least a portion of the catheter (22, 120). The catheter (22, 120) is configured to direct infrared light along the first optical fiber to illuminate a subcutaneous region of the patient, and to further obtain reflected light data via the second optical fiber based on the infrared light reflected from cells present in the subcutaneous region. Based on the reflected light data, the stroke detection device (50, 100) monitors SjVO2 levels for early detection of ischemic strokes.

Abstract: A medical device for detecting at least one analyte in a body fluid is disclosed.

Abstract: Embodiments herein relate to systems and methods for rapidly calibrating optical medical sensors. In an embodiment, a method can include placing a reflective optical medical sensor device on or in a patient. The reflective optical medical sensor device can include one or more optical emitters; one or more optical detectors; and a measurement circuit having one or more transimpedance amplifiers (TIA). The method can include setting the TIA to a fixed gain value and then turning on the optical emitter associated with each spatially unique measurement vector and receiving reflected light with the associated optical detector for each spatially unique measurement vector at the same fixed gain value. The method can include assessing the signal-to-noise (SNR) for each spatially unique measurement vector and selecting the spatially unique measurement vector having the highest SNR. Other embodiments are also included herein.

Abstract: Aspects of the present disclosure include a sensor configured to store in memory indications of sensor use information and formulas or indications of formulas for determining the useful life of a sensor from the indications of sensor use information. A monitor connected to the sensor monitors sensor use and stores indications of the use on sensor memory. The monitor and/or sensor compute the useful life of the sensor from the indications of use and the formulas. When the useful life of the sensor is reached, an indication is given to replace the sensor.

Abstract: The present disclosure provides a method of detecting a presence of methemoglobin in a tissue-of-interest using photoacoustic techniques, the method including acquiring photoacoustic data sets at different wavelengths from the tissue-of-interest, computing a relationship between at least two of the data sets, and analyzing the relationship to determine the presence of methemoglobin in the tissue-of-interest. Methods of monitoring therapy are also disclosed.

Abstract: A vascular access device may include a housing, which may include a proximal end, a distal end, and a slot. The distal end of the housing may be configured to be coupled to a catheter assembly. The vascular access device may also include an instrument disposed within the housing. The instrument may include a catheter or a probe. The instrument may include a proximal end and a distal tip. The proximal end of the instrument may extend through the slot and may be configured to move along the slot to move the instrument from a proximal position to a distal position. In response to movement of the proximal end of the instrument from the proximal position to the distal position, the catheter may be advanced beyond the distal end of the housing into the catheter assembly and/or vasculature of a patient.

Abstract: The present disclosure provides compositions, methods, systems, and apparatuses for treating disorders or illnesses. The composition may comprise at least one substance based on or derived from cocoa beans or coffee beans provided to be used in the methods, systems, and apparatuses and consumed by a patient for treatment of a disorder or illness. The systems and apparatuses, generally used in combination with the compositions, may comprise at least one device (e.g., a sensor) configured to monitor at least one action performed by a patient, and at least one processor.

Abstract: A system for diagnosing vestibular otolith function can comprise an ultrasonic generator that is configured to direct ultrasonic waves towards vestibular organs with a patient's ear. The system can also comprise a response capture device that is configured to capture patient response to the ultrasonic waves.

Abstract: A sensor including electrodes, a control module and a physical layer module. The electrodes are configured to (i) attach to a patient, and (ii) receive a first electromyographic signal from the patient. The control module is connected to the electrodes. The control module is configured to (i) detect the first electromyographic signal, and (ii) generate a first voltage signal. The physical layer module is configured to: receive a payload request from a console interface module or a nerve integrity monitoring device; and based on the payload request, (i) upconvert the first voltage signal to a first radio frequency signal, and (ii) wirelessly transmit the first radio frequency signal from the sensor to the console interface module or the nerve integrity monitoring device.

Abstract: A sensor including electrodes, a control module and a physical layer module. The electrodes are configured to (i) attach to a patient, and (ii) receive a first electromyographic signal from the patient. The control module is connected to the electrodes. The control module is configured to (i) detect the first electromyographic signal, and (ii) generate a first voltage signal. The physical layer module is configured to: receive a payload request from a console interface module or a nerve integrity monitoring device; and based on the payload request, (i) upconvert the first voltage signal to a first radio frequency signal, and (ii) wirelessly transmit the first radio frequency signal from the sensor to the console interface module or the nerve integrity monitoring device.

Abstract: An olfactory examination apparatus includes: an odor generating unit having an odorant generating mechanism that stores an odorant and generates an odorous gas having a defined concentration or an defined intensity and an odorless gas generating mechanism; a gas supply unit configured to alternately supply an odorous gas or an odorless gas having a defined concentration or a defined intensity of the odor from the odorant generating mechanism and the odorless gas generating mechanism to an examinee through an odor presentation mechanism placed on a nostril portion of the examinee, and a reply unit that allows the examinee to express an answer when smelling the odorant in order to examine an olfactory function.

Abstract: A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig's disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Abstract: A system and method to screen for malignant gliomas, other brain tumors, and brain injuries use disturbance coefficient, differential impedances, and artificial neural networks. The system uses prescribed excitation signals with several system configurations to measure the differential impedances, calculate harmonic responses and nonlinearity of brain tissue, and estimate the disturbance coefficient that indicates the likelihood of malignant gliomas, other brain tumors, and brain injuries. The disturbance coefficient is a weighted sum of many parameters such as receiving differential impedances, transmission differential impedances, harmonic responses, frequency dispersion, and nonlinear responses using different system configurations and different excitation signals. The method includes arranging the transmitters, receivers, and transmission lines to maximize the sensitivity of detecting brain tissue condition.

Abstract: An apparatus and method are provided for use in studying a patient's bowel which combines recording and analysis of physiologic parameters and patient sensory perception. A pain input detector, a pain transducer, and a processor are provided. A gas pressure transducer and flow meter may also be provided. Output data may be generated to reflect perceived patient pain, volume of gas delivered to the patient's bowel, and bowel pressure. An indication of perceived patient pain is processed by the processor to generate data that may used to validate a scan of a patient or may be used as a diagnostic tool.

Abstract: A medical diagnostic apparatus includes a controller; a user interface; a platform having a horizontal surface; and at least one visible light image sensor positioned below the horizontal surface that is capable of producing a diagnostic visible light image of a bottom portion of a foot or feet positioned on the horizontal surface. At least a portion of the horizontal surface is transparent to visible light. The apparatus may further include at least one infrared image sensor positioned below the horizontal surface that is capable of producing a thermal image of the first target area. The apparatus may further include sensors positioned above the platform capable of producing diagnostic visible light images or thermal images of a top portion of the user's foot or feet. The apparatus may further include a weight measurement system coupled to the platform.

Abstract: Provided herein are methods and systems for monitoring a patient using a pressure-sensing device containing a pressure-sensitive region configured to selectively overlie a pressure ulcer-prone body part of the patient. In some embodiments, the pressure-sensing device includes a multilayered sensing unit containing a pressure-sensing layer to sense force and an adhesive layer configured to attach the pressure-sensing device to the body part. Also provided is a kit that includes the pressure-sensing device. The present methods, systems, and kits may find use in reducing the risk of pressure ulcer development in a patient.

Abstract: A method for capturing patient-individual movements of a mandible in relation to a maxilla in a plurality of degrees of freedom. The method includes providing an optical sensor system having an image in an oral cavity of a patient, providing a defined object in the image of the optical sensor system in the oral cavity of the patient, bringing the optical sensor system into a fixed connection to the mandible or to the maxilla, capturing the defined object with the optical sensor system, the defined object having a defined relationship to the other maxilla or mandible, recording a sequence of spatial points of the defined object with the optical sensor system during a movement of the mandible, and storing the sequence of spatial points as a multi-dimensional movement line in a movement data record.

Abstract: Embodiments of the invention are directed to computer-implemented methods, computer systems, and computer program products for monitoring the ergonomics of a user. A non-limiting example method includes capturing a reference image of the user using an image capture device. The method further includes determining a first height of an object of interest of the user using the reference image of the user. The method further includes capturing a subsequent image of the user using the image capture device. The method further includes determining a second height of the object of interest of the user using the subsequent image of the user. Based at least in part on determining that the second height is not within a first tolerance of the first height, causing the issuance of a warning that the user is not within an optimal distance from the image capture device.

Abstract: Embodiments of the invention are directed to computer-implemented methods, computer systems, and computer program products for monitoring the ergonomics of a user. A non-limiting example method includes capturing a reference image of the user using an image capture device. The method further includes determining a first height of an object of interest of the user using the reference image of the user. The method further includes capturing a subsequent image of the user using the image capture device. The method further includes determining a second height of the object of interest of the user using the subsequent image of the user. Based at least in part on determining that the second height is not within a first tolerance of the first height, causing the issuance of a warning that the user is not within an optimal distance from the image capture device.

Abstract: Sleep related conditions of a subject are monitored and/or diagnosed based on both sleep quality and apnea hypopnea index. A first sleep test is performed in which a sleep quality of the subject and an apnea-hypopnea index are determined. A determination is made as to whether results of the first sleep test meet a first condition based on both the sleep quality and apnea-hypopnea index of the subject associated with the first sleep test. Responsive to the results of the first sleep test failing to meet the first condition, a recommendation of a treatment for the subject is provided. An efficacy of the treatment is confirmed in a second sleep test involving the treatment by determining whether results of the second sleep test meet the first condition based on both the sleep quality and apnea-hypopnea index of the subject associated with the second sleep test.

Abstract: A patient monitoring system includes an electroencephalography (EEG) monitor and an EEG sensor array. The EEG sensor array includes a plurality of electrodes configured to acquire EEG signals from a patient. The EEG monitor may be configured to calculate one or more depth of anesthesia indices for the patient based on received EEG signals from the EEG sensor array. Additionally, the EEG monitor may be configured to generate and display a topographic color map of the calculated depth of anesthesia indices.